Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled acetylcholine receptor activity	CHRM1 CHRM5	5.88e-05	7	34	2	GO:0016907
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	CHRM1 CHRM5	2.17e-04	13	34	2	GO:0099528
GeneOntologyMolecularFunction	arachidonate binding	CYP4F8 GPR31	2.91e-04	15	34	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F8 GPR31	3.33e-04	16	34	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F8 GPR31	3.33e-04	16	34	2	GO:0050543
GeneOntologyMolecularFunction	bioactive lipid receptor activity	SPHK2 GPR31	3.33e-04	16	34	2	GO:0045125
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	CHRM1 CHRM5	6.36e-04	22	34	2	GO:0004993
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRM1 CHRM5	6.96e-04	23	34	2	GO:0015464
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	CHRM1 CHRM5	8.91e-04	26	34	2	GO:0004435
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4F8 GPR31	1.03e-03	28	34	2	GO:0036041
GeneOntologyMolecularFunction	phospholipase C activity	CHRM1 CHRM5	1.11e-03	29	34	2	GO:0004629
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	CHRM1 CHRM5	2.21e-03	41	34	2	GO:0008227
GeneOntologyMolecularFunction	lipid kinase activity	SPHK2 PIP5K1C	2.21e-03	41	34	2	GO:0001727
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	ANO7 CHRM5	3.28e-03	50	34	2	GO:0099095
GeneOntologyMolecularFunction	extracellular matrix structural constituent	HAPLN4 MUC3A TFPI2	3.97e-03	188	34	3	GO:0005201
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	TUT4 PUS3 CARS2 TERF2 DNMT1	4.43e-03	645	34	5	GO:0140640
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	SPHK2 BMPR1B TUT4 LATS2 PIP5K1C TERF2	4.60e-03	938	34	6	GO:0016772
Domain	Musac_Ach_rcpt	CHRM1 CHRM5	3.21e-05	5	34	2	IPR000995
Domain	TF_fork_head_CS_2	FOXD2 FOXD4	3.17e-03	46	34	2	IPR030456
Domain	TF_fork_head_CS_1	FOXD2 FOXD4	3.30e-03	47	34	2	IPR018122
Domain	FORK_HEAD_3	FOXD2 FOXD4	3.59e-03	49	34	2	PS50039
Domain	FH	FOXD2 FOXD4	3.59e-03	49	34	2	SM00339
Domain	FORK_HEAD_1	FOXD2 FOXD4	3.59e-03	49	34	2	PS00657
Domain	FORK_HEAD_2	FOXD2 FOXD4	3.59e-03	49	34	2	PS00658
Domain	Forkhead	FOXD2 FOXD4	3.59e-03	49	34	2	PF00250
Domain	Fork_head_dom	FOXD2 FOXD4	3.59e-03	49	34	2	IPR001766
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM5	3.01e-05	5	25	2	M27300
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM5	3.01e-05	5	25	2	MM15006
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	TGFB2 BMPR1B EFHC1 TERF2 CHRM1	6.72e-07	171	34	5	20201926
Pubmed	Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM5	9.28e-07	2	34	2	17586055
Pubmed	The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists.	CHRM1 CHRM5	9.28e-07	2	34	2	16877267
Pubmed	TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.	TGFB2 TFPI2	9.28e-07	2	34	2	35157852
Pubmed	Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors.	CHRM1 CHRM5	9.28e-07	2	34	2	17286988
Pubmed	Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.	CHRM1 CHRM5	2.78e-06	3	34	2	1905013
Pubmed	Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.	CHRM1 CHRM5	2.78e-06	3	34	2	16956767
Pubmed	M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.	CHRM1 CHRM5	2.78e-06	3	34	2	19657040
Pubmed	Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.	CHRM1 CHRM5	2.78e-06	3	34	2	23649821
Pubmed	M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.	CHRM1 CHRM5	2.78e-06	3	34	2	15146045
Pubmed	Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice.	CHRM1 CHRM5	2.78e-06	3	34	2	15691866
Pubmed	Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway.	LATS2 DNMT1	2.78e-06	3	34	2	34459131
Pubmed	Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.	CHRM1 CHRM5	2.78e-06	3	34	2	21335473
Pubmed	Ciliary activity in the oviduct of cycling, pregnant, and muscarinic receptor knockout mice.	CHRM1 CHRM5	5.56e-06	4	34	2	22302687
Pubmed	Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.	CHRM1 CHRM5	5.56e-06	4	34	2	8063729
Pubmed	Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma.	LATS2 DNMT1	5.56e-06	4	34	2	31097223
Pubmed	Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes.	CHRM1 CHRM5	5.56e-06	4	34	2	11855742
Pubmed	Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.	CHRM1 CHRM5	9.26e-06	5	34	2	24695732
Pubmed	Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.	CHRM1 CHRM5	9.26e-06	5	34	2	20940295
Pubmed	Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography.	CHRM1 CHRM5	9.26e-06	5	34	2	7648406
Pubmed	Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.	CHRM1 CHRM5	9.26e-06	5	34	2	26084221
Pubmed	Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.	CHRM1 CHRM5	9.26e-06	5	34	2	15574798
Pubmed	Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice.	CHRM1 CHRM5	9.26e-06	5	34	2	15919709
Pubmed	Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.	CHRM1 CHRM5	9.26e-06	5	34	2	12675128
Pubmed	Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.	CHRM1 CHRM5	9.26e-06	5	34	2	15913791
Pubmed	Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.	CHRM1 CHRM5	9.26e-06	5	34	2	11306684
Pubmed	Muscarinic acetylcholine receptor subtypes: localization and structure/function.	CHRM1 CHRM5	9.26e-06	5	34	2	8248499
Pubmed	The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.	CHRM1 CHRM5	9.26e-06	5	34	2	30914695
Pubmed	Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.	CHRM1 CHRM5	9.26e-06	5	34	2	12151512
Pubmed	Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.	CHRM1 CHRM5	9.26e-06	5	34	2	29401598
Pubmed	Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM5	9.26e-06	5	34	2	15661360
Pubmed	Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.	CHRM1 CHRM5	9.26e-06	5	34	2	19213795
Pubmed	The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse.	CHRM1 CHRM5	9.26e-06	5	34	2	18755247
Pubmed	Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.	CHRM1 CHRM5	9.26e-06	5	34	2	20463237
Pubmed	Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.	CHRM1 CHRM5	9.26e-06	5	34	2	19940190
Pubmed	Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.	CHRM1 CHRM5	1.39e-05	6	34	2	31914675
Pubmed	The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.	CHRM1 CHRM5	1.39e-05	6	34	2	19182865
Pubmed	A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development.	CHRM1 CHRM5	1.94e-05	7	34	2	35427599
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD2 FOXD4	3.33e-05	9	34	2	12412011
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRM1 CHRM5	4.15e-05	10	34	2	10336173
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	CHRM1 CHRM5	1.25e-04	17	34	2	10549128
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM1 CHRM5	1.57e-04	19	34	2	17373692
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	CHRM1 CHRM5	1.93e-04	21	34	2	15452121
Pubmed	Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.	TGFB2 LATS2	2.12e-04	22	34	2	21512031
Pubmed	Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.	TGFB2 BMPR1B	2.32e-04	23	34	2	14701881
Pubmed	Fstl1 antagonizes BMP signaling and regulates ureter development.	TGFB2 BMPR1B	2.74e-04	25	34	2	22485132
Pubmed	The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.	TGFB2 BMPR1B	2.97e-04	26	34	2	31311865
Pubmed	Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.	EFHC1 DNMT1	2.97e-04	26	34	2	25820252
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	IFNK TGFB2 BMPR1B NECTIN3	2.98e-04	331	34	4	20634891
Pubmed	Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice.	TGFB2 BMPR1B	3.70e-04	29	34	2	21909369
Pubmed	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.	TGFB2 LATS2	3.70e-04	29	34	2	27358050
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	NLRP4 DNMT1	4.52e-04	32	34	2	38060382
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	BMPR1B TUT4 LATS2 CARS2 PIP5K1C	6.75e-04	730	34	5	34857952
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TUT4 NECTIN3 JMJD1C TTLL4 DNMT1	6.88e-04	733	34	5	34672954
Pubmed	Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.	TUT4 TTLL4	7.43e-04	41	34	2	8724849
Cytoband	7q22	MUC3A TFPI2	3.68e-04	38	34	2	7q22
Cytoband	19p13.1	HAPLN4 CYP4F8	5.88e-04	48	34	2	19p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	ANO7 ANKMY1 B3GNT7	6.29e-04	226	34	3	chr2q37
Cytoband	2q37.3	ANO7 ANKMY1	1.50e-03	77	34	2	2q37.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	HAPLN4 CYP4F8 PIP5K1C DNMT1	2.76e-03	797	34	4	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	C1QTNF4 ACCSL	5.77e-03	153	34	2	chr11p11
GeneFamily	Cholinergic receptors muscarinic	CHRM1 CHRM5	1.68e-05	5	24	2	180
GeneFamily	Forkhead boxes	FOXD2 FOXD4	1.48e-03	43	24	2	508
ToppCell	VE-Treg-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	FOXD2 C1QTNF4 CARS2 TTLL4	7.78e-06	167	34	4	1036ac1ef9440612500137af9d1929672b077e4d
ToppCell	facs-Skin-Anagen-24m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO7 ACCSL GPR31 CHRM5	7.78e-06	167	34	4	02c89069dcd0e87f7502e32b14e7cbd3cab81a09
Drug	hexocyclium	CHRM1 CHRM5	1.30e-05	4	34	2	CID000024199
Drug	Botiacrine	CHRM1 CHRM5	1.30e-05	4	34	2	CID000071202
Drug	Tolterodine	CHRM1 CHRM5	2.16e-05	5	34	2	DB01036
Drug	Atropine	CHRM1 CHRM5	2.16e-05	5	34	2	DB00572
Drug	Fesoterodine	CHRM1 CHRM5	2.16e-05	5	34	2	DB06702
Drug	Darifenacin	CHRM1 CHRM5	2.16e-05	5	34	2	DB00496
Drug	Metixene	CHRM1 CHRM5	2.16e-05	5	34	2	DB00340
Drug	Trihexyphenidyl	CHRM1 CHRM5	2.16e-05	5	34	2	DB00376
Drug	Solifenacin	CHRM1 CHRM5	2.16e-05	5	34	2	DB01591
Drug	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	CHRM1 CHRM5	2.16e-05	5	34	2	ctd:C568516
Drug	Pipecuronium	CHRM1 CHRM5	2.16e-05	5	34	2	ctd:D017300
Drug	N-Methylscopolamine	CHRM1 CHRM5	2.16e-05	5	34	2	ctd:D019832
Drug	F 2268	CHRM1 CHRM5	2.16e-05	5	34	2	CID000020410
Drug	Cryptenamine	CHRM1 CHRM5	2.16e-05	5	34	2	DB00785
Drug	Homatropine Methylbromide	CHRM1 CHRM5	2.16e-05	5	34	2	DB00725
Drug	hexahydro-difenidol	CHRM1 CHRM5	2.16e-05	5	34	2	CID000124226
Drug	Quinuclidinyl Benzilate	CHRM1 CHRM5	2.16e-05	5	34	2	ctd:D011813
Drug	eucatropine	CHRM1 CHRM5	2.16e-05	5	34	2	CID000007534
Drug	Nsc34399	CHRM1 CHRM5	3.23e-05	6	34	2	CID000003622
Drug	Gallamine Triethiodide	CHRM1 CHRM5	3.23e-05	6	34	2	ctd:D005703
Drug	Dactil	CHRM1 CHRM5	3.23e-05	6	34	2	CID000004839
Drug	4-diphenylacetoxy-1,1-dimethylpiperidinium	CHRM1 CHRM5	3.23e-05	6	34	2	ctd:C042375
Drug	brucine N-oxide	CHRM1 CHRM5	3.23e-05	6	34	2	ctd:C083067
Drug	Brompheniramine	CHRM1 CHRM5	3.23e-05	6	34	2	DB00835
Drug	Benzquinamide	CHRM1 CHRM5	3.23e-05	6	34	2	DB00767
Drug	Scopolamine	CHRM1 CHRM5	3.23e-05	6	34	2	DB00747
Drug	Crotalid Venoms	CHRM1 CHRM5	3.23e-05	6	34	2	ctd:D003435
Drug	N-methylscopolamine	CHRM1 CHRM5 DNMT1	3.36e-05	42	34	3	CID000004120
Drug	Tiotropium Bromide	CHRM1 CHRM5	4.52e-05	7	34	2	ctd:D000069447
Drug	secoverine	CHRM1 CHRM5	6.03e-05	8	34	2	CID000042470
Drug	aceclidine	CHRM1 CHRM5	6.03e-05	8	34	2	CID000001979
Drug	Pirenzepine	CHRM1 CHRM5	6.03e-05	8	34	2	ctd:D010890
Drug	Maprotiline	CHRM1 CHRM5	6.03e-05	8	34	2	DB00934
Drug	Paroxetine	CHRM1 CHRM5	6.03e-05	8	34	2	DB00715
Drug	Trest	CHRM1 CHRM5	7.74e-05	9	34	2	CID000004167
Drug	methylfurmethide	CHRM1 CHRM5	7.74e-05	9	34	2	CID000004141
Drug	sila-hexocyclium	CHRM1 CHRM5	7.74e-05	9	34	2	CID000130169
Drug	Rilapinum	CHRM1 CHRM5	7.74e-05	9	34	2	CID006446980
Drug	Promethazine	CHRM1 CHRM5	9.67e-05	10	34	2	DB01069
Drug	tenilapine	CHRM1 CHRM5	9.67e-05	10	34	2	CID006450478
Drug	homatropin	CHRM1 CHRM5	1.18e-04	11	34	2	CID000003623
Drug	Imipramine	CHRM1 CHRM5	1.18e-04	11	34	2	DB00458
Drug	Pancuronium	CHRM1 CHRM5	1.18e-04	11	34	2	ctd:D010197
Drug	cyclopentolate	CHRM1 CHRM5	1.18e-04	11	34	2	CID000002905
Drug	dicyclomine	CHRM1 CHRM5	1.18e-04	11	34	2	CID000003042
Drug	rocuronium	CHRM1 CHRM5	1.18e-04	11	34	2	ctd:C061870
Drug	3 tp	TGFB2 BMPR1B DNMT1	1.31e-04	66	34	3	CID009549240
Drug	Nortriptyline	CHRM1 CHRM5	1.42e-04	12	34	2	DB00540
Drug	Vecuronium Bromide	CHRM1 CHRM5	1.42e-04	12	34	2	ctd:D014673
Drug	AQ-RA 741	CHRM1 CHRM5	1.42e-04	12	34	2	CID000129989
Drug	Chlorprothixene	CHRM1 CHRM5	1.42e-04	12	34	2	DB01239
Drug	p-F-HHSiD	CHRM1 CHRM5	1.67e-04	13	34	2	CID000003603
Drug	Desipramine	CHRM1 CHRM5	1.67e-04	13	34	2	DB01151
Drug	propiomazine	CHRM1 CHRM5	1.95e-04	14	34	2	CID000004940
Drug	Promazine	CHRM1 CHRM5	1.95e-04	14	34	2	DB00420
Drug	methoctramine	CHRM1 CHRM5	1.95e-04	14	34	2	ctd:C054938
Drug	Propiomazine	CHRM1 CHRM5	1.95e-04	14	34	2	DB00777
Drug	Nicardipine	CHRM1 CHRM5	1.95e-04	14	34	2	DB00622
Drug	Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	TGFB2 SPHK2 NT5DC3 TTLL4	2.06e-04	197	34	4	3399_DN
Drug	thiethylperazine	CHRM1 CHRM5	2.25e-04	15	34	2	CID000005440
Drug	AF-DX 384	CHRM1 CHRM5	2.25e-04	15	34	2	CID000119356
Drug	NSC172130	CHRM1 CHRM5	2.25e-04	15	34	2	CID000003155
Drug	AC1NSJZ2	CHRM1 CHRM5	2.90e-04	17	34	2	CID005311091
Drug	PGW5 compound	CHRM1 CHRM5	2.90e-04	17	34	2	ctd:C000593032
Drug	Amitriptyline	CHRM1 CHRM5	3.26e-04	18	34	2	DB00321
Drug	tripitramine	CHRM1 CHRM5	3.26e-04	18	34	2	CID000132947
Drug	aprophen	CHRM1 CHRM5	3.26e-04	18	34	2	CID000071128
Drug	Nozinan	CHRM1 CHRM5	3.26e-04	18	34	2	CID000003916
Drug	tiospirone	CHRM1 CHRM5	3.64e-04	19	34	2	CID000055751
Drug	Methotrimeprazine	CHRM1 CHRM5	3.64e-04	19	34	2	DB01403
Drug	femoxitine	CHRM1 CHRM5	3.64e-04	19	34	2	CID000043103
Drug	bromperidol	CHRM1 CHRM5	4.04e-04	20	34	2	CID000002448
Drug	Doxepin	CHRM1 CHRM5	4.04e-04	20	34	2	DB01142
Drug	telenzepine	CHRM1 CHRM5	4.91e-04	22	34	2	CID000005387
Drug	metoprolol	LATS2 CHRM1 CHRM5	5.14e-04	105	34	3	CID000004171
Drug	biperiden	CHRM1 CHRM5	5.37e-04	23	34	2	CID000002381
Drug	lofepramine	CHRM1 CHRM5	5.37e-04	23	34	2	CID000003947
Drug	procyclidine	CHRM1 CHRM5	5.85e-04	24	34	2	CID000004919
Drug	Endocrine Disruptors	BMPR1B EFHC1 TFPI2	5.89e-04	110	34	3	ctd:D052244
Drug	Olanzapine	CHRM1 CHRM5	6.36e-04	25	34	2	DB00334
Drug	Ziprasidone	CHRM1 CHRM5	6.36e-04	25	34	2	DB00246
Drug	Aripiprazole	CHRM1 CHRM5	6.36e-04	25	34	2	DB01238
Drug	T15550	CHRM1 CHRM5	6.88e-04	26	34	2	CID000005454
Drug	benzquinamide	CHRM1 CHRM5	6.88e-04	26	34	2	CID000002342
Drug	cyamemazine	CHRM1 CHRM5	6.88e-04	26	34	2	CID000062865
Drug	Clozapine	CHRM1 CHRM5	6.88e-04	26	34	2	DB00363
Drug	tardan	CHRM1 CHRM5	6.88e-04	26	34	2	CID000002729
Drug	Quetiapine	CHRM1 CHRM5	6.88e-04	26	34	2	DB01224
Drug	fluperlapine	CHRM1 CHRM5	7.42e-04	27	34	2	CID000049381
Disease	Eye Abnormalities	TGFB2 BMPR1B	1.63e-04	17	33	2	C0015393
Disease	Bone Diseases, Developmental	TGFB2 BMPR1B	4.18e-04	27	33	2	C0005941
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	HAPLN4 IRGC JMJD1C	4.82e-04	137	33	3	EFO_0004611, EFO_0008591
Disease	Memory Disorders	SPHK2 CHRM1	1.06e-03	43	33	2	C0025261
Disease	Memory Loss	SPHK2 CHRM1	1.06e-03	43	33	2	C0751295
Disease	Age-Related Memory Disorders	SPHK2 CHRM1	1.06e-03	43	33	2	C0751292
Disease	Memory Disorder, Spatial	SPHK2 CHRM1	1.06e-03	43	33	2	C0751294
Disease	Memory Disorder, Semantic	SPHK2 CHRM1	1.06e-03	43	33	2	C0751293
Disease	Memory impairment	SPHK2 CHRM1	1.11e-03	44	33	2	C0233794
Disease	response to fenofibrate	CYP4F8 JMJD1C	1.44e-03	50	33	2	GO_1901557
Disease	pancreatic ductal carcinoma (is_marker_for)	MUC3A DNMT1	2.13e-03	61	33	2	DOID:3587 (is_marker_for)
Disease	ceramide measurement	HAPLN4 SPHK2 ANKMY1	2.28e-03	235	33	3	EFO_0010222
Disease	intermediate density lipoprotein measurement	HAPLN4 JMJD1C	4.28e-03	87	33	2	EFO_0008595

Protein segments in the cluster

Peptide	Gene	Start	Entry
PFLREEVARFLTYYC	ACCSL	211	Q4AC99
FLSYCDYYRPRFFLL	DNMT1	1251	P26358
VYCFSSPTFRSSYRR	GPR31	281	O00270
EFLTRAYTFYPSRLF	APCDD1L	71	Q8NCL9
FRCRLPGAYFFSFTL	C1QTNF4	221	Q9BXJ3
CYFRYKRQETRPRYS	BMPR1B	146	O00238
EYYSCRFRVNKLPRF	ANO7	226	Q6IWH7
TFRRFFDDNGYPFRC	LATS2	1041	Q9NRM7
AHSPVFCRFYYFRRL	JMJD1C	1746	Q15652
FCRFYYFRRLSFSKN	JMJD1C	1751	Q15652
ICRRAAPTGYEEFYF	MUC3A	3151	Q02505
KIFRDRFLYTFYFCC	NLRP4	176	Q96MN2
RFLYTFYFCCRELRE	NLRP4	181	Q96MN2
FRPYRTDDFITRLYY	CYHR1	236	Q6ZMK1
CAFISDRFPYYRRKF	FOXD4	131	Q12950
FSRYDFFLLVSPRRC	IRGC	131	Q6NXR0
YFATFYSCTPRMNRR	FAM189A2	151	Q15884
RYKDFLYFLTPCGRR	CYP4F8	241	P98187
RRCLYYFYKFTALFR	IFNK	191	Q9P0W0
FDRYFSVTRPLSYRA	CHRM1	121	P11229
YFRFFQDRRIARCPF	ANKMY1	786	Q9P2S6
TFFIYDCDPFTRRYY	EFHC1	341	Q5JVL4
FPDATRRLFGVYCYR	HAPLN4	351	Q86UW8
PQFRQFLFYRHCRYF	B3GNT7	106	Q8NFL0
SEICEFISGRFPYYR	FOXD2	151	O60548
SPDVFRFFCLRSSYR	CARS2	336	Q9HA77
ARFSCLERTYRYFFP	PUS3	186	Q9BZE2
PTYFLRRLSRFADIY	NT5DC3	486	Q86UY8
FRYFRELFGIRPDDY	PIP5K1C	141	O60331
LYYVREFVSRFPDCR	SGO1	536	Q5FBB7
FDRYFSITRPLTYRA	CHRM5	126	P08912
TFYRPYFRIVRFDVS	TGFB2	121	P61812
SAAYFCIYTYPRGRR	SPHK2	111	Q9NRA0
VTRYYFNPRYRTCDA	TFPI2	171	P48307
VVERFRAAYRYFACP	TUT4	696	Q5TAX3
ISSRYLRFFEQPRYF	TTLL4	1031	Q14679
FYFHEALRAFRGSRY	TERF2	101	Q15554
FCYRRRRTFRGDYFA	NECTIN3	426	Q9NQS3