Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1C

1.59e-0514723GO:0008331
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT6A KRT6B KRT6C KRT77

1.72e-0543724GO:0030280
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B

4.54e-049722GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B

4.54e-049722GO:0099626
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1C

6.11e-0446723GO:0005245
GeneOntologyMolecularFunctionantigen binding

IGHV3-33 IGHV3-30 IGHV3-20 IGHV3-30-5 IGHV3-30-3

6.18e-04190725GO:0003823
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CACNA1B CACNA1C PKDREJ

1.22e-03129724GO:0005262
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

DES KRT6A KRT6B ARHGEF28 KRT6C KRT77 DNAJB6 PKP2

1.56e-0999708GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

DES KRT6A KRT6B ARHGEF28 KRT6C KRT77 DNAJB6 PKP2

1.69e-09100708GO:0045103
GeneOntologyBiologicalProcessintermediate filament organization

DES KRT6A KRT6B KRT6C KRT77 DNAJB6 PKP2

6.30e-0975707GO:0045109
GeneOntologyBiologicalProcesskeratinization

KRT6A KRT6B KRT6C KRT77 HRNR

1.16e-0587705GO:0031424
GeneOntologyCellularComponentintermediate filament cytoskeleton

DES KRT6A KRT6B KRT6C CLK3 KRT77 PKP2

2.81e-05263707GO:0045111
GeneOntologyCellularComponentcornified envelope

KRT77 PKP2 HRNR FLG2

8.46e-0569704GO:0001533
GeneOntologyCellularComponentkeratohyalin granule

HRNR FLG2

1.10e-045702GO:0036457
GeneOntologyCellularComponentintermediate filament

DES KRT6A KRT6B KRT6C KRT77 PKP2

1.13e-04227706GO:0005882
GeneOntologyCellularComponentimmunoglobulin complex

IGHV3-33 IGHV3-30 IGHV3-20 IGHV3-30-5 IGHV3-30-3

2.37e-04166705GO:0019814
GeneOntologyCellularComponentkeratin filament

KRT6A KRT6B KRT6C KRT77

3.16e-0497704GO:0045095
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1B CACNA1C

4.92e-0446703GO:0005891
GeneOntologyCellularComponentcell tip

DES PKP2

1.46e-0317702GO:0051286
GeneOntologyCellularComponentsupramolecular fiber

THSD4 CACNA1C DES KRT6A KRT6B MYO1A KRT6C KRT77 DNAJB6 PKP2 CCT7

1.77e-0311797011GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

THSD4 CACNA1C DES KRT6A KRT6B MYO1A KRT6C KRT77 DNAJB6 PKP2 CCT7

1.87e-0311877011GO:0099081
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1B CACNA1C

1.89e-0373703GO:0034704
GeneOntologyCellularComponentdendritic shaft

CACNA1B CACNA1C INPP5J

1.97e-0374703GO:0043198
GeneOntologyCellularComponentcell pole

DES PKP2

2.02e-0320702GO:0060187
HumanPhenoSteatocystoma multiplex

KRT6A KRT6B

9.67e-054212HP:0012035
HumanPhenoEruptive vellus hair cyst

KRT6A KRT6B

9.67e-054212HP:0025248
HumanPhenoLinear arrays of macular hyperkeratoses in flexural areas

KRT6A KRT6B

1.61e-045212HP:0007490
HumanPhenoHyperplastic callus formation

KRT6A KRT6B

1.61e-045212HP:0030268
HumanPhenoWhite lesion of the oral mucosa

KRT6A KRT6B KRT6C

1.85e-0428213HP:0025125
HumanPhenoOral leukoplakia

KRT6A KRT6B KRT6C

1.85e-0428213HP:0002745
DomainVDCC_a1su_IQ

CACNA1A CACNA1B CACNA1C

1.60e-067683IPR014873
DomainGPHH

CACNA1A CACNA1B CACNA1C

1.60e-067683PF16905
DomainGPHH_dom

CACNA1A CACNA1B CACNA1C

1.60e-067683IPR031649
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1C

1.60e-067683SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1C

1.60e-067683PF08763
DomainKeratin_2_head

KRT6A KRT6B KRT6C KRT77

1.62e-0624684IPR032444
DomainKeratin_2_head

KRT6A KRT6B KRT6C KRT77

1.62e-0624684PF16208
DomainKeratin_II

KRT6A KRT6B KRT6C KRT77

2.26e-0626684IPR003054
DomainIntermediate_filament_CS

DES KRT6A KRT6B KRT6C KRT77

3.29e-0663685IPR018039
DomainVDCCAlpha1

CACNA1A CACNA1B CACNA1C

5.44e-0610683IPR002077
DomainFilament

DES KRT6A KRT6B KRT6C KRT77

5.96e-0671685SM01391
DomainIF

DES KRT6A KRT6B KRT6C KRT77

6.38e-0672685PS00226
DomainFilament

DES KRT6A KRT6B KRT6C KRT77

6.83e-0673685PF00038
DomainIF

DES KRT6A KRT6B KRT6C KRT77

8.33e-0676685IPR001664
DomainKH_1

IGF2BP3 KHDRBS3 DDX43

3.55e-0438683PF00013
Domain-

IGF2BP3 KHDRBS3 DDX43

3.84e-04396833.30.1370.10
DomainKH

IGF2BP3 KHDRBS3 DDX43

4.14e-0440683SM00322
DomainKH_dom

IGF2BP3 KHDRBS3 DDX43

4.14e-0440683IPR004087
DomainKH_TYPE_1

IGF2BP3 KHDRBS3 DDX43

4.79e-0442683PS50084
DomainKH_dom_type_1

IGF2BP3 KHDRBS3 DDX43

5.49e-0444683IPR004088
DomainPLAC

THSD4 ADAMTSL1

1.16e-0314682PF08686
DomainChannel_four-helix_dom

CACNA1A CACNA1B CACNA1C

1.17e-0357683IPR027359
Domain-

CACNA1A CACNA1B CACNA1C

1.17e-03576831.20.120.350
DomainPLAC

THSD4 ADAMTSL1

2.15e-0319682PS50900
DomainPLAC

THSD4 ADAMTSL1

2.15e-0319682IPR010909
DomainS100_CABP

HRNR FLG2

4.32e-0327682PS00303
DomainS_100

HRNR FLG2

4.32e-0327682PF01023
DomainS100_Ca-bd_sub

HRNR FLG2

4.64e-0328682IPR013787
DomainS100/CaBP-9k_CS

HRNR FLG2

4.64e-0328682IPR001751
DomainS_100

HRNR FLG2

4.64e-0328682SM01394
DomainGPS

CELSR2 PKDREJ

6.80e-0334682SM00303
DomainRRM_1

IGF2BP3 RBMXL3 RBM12B RBM10

6.98e-03208684PF00076
DomainGPS

CELSR2 PKDREJ

8.01e-0337682IPR000203
DomainRRM

IGF2BP3 RBMXL3 RBM12B RBM10

8.08e-03217684SM00360
DomainIon_trans_dom

CACNA1A CACNA1B CACNA1C

8.32e-03114683IPR005821
DomainIon_trans

CACNA1A CACNA1B CACNA1C

8.32e-03114683PF00520
DomainRRM_dom

IGF2BP3 RBMXL3 RBM12B RBM10

9.43e-03227684IPR000504
DomainRRM

IGF2BP3 RBMXL3 RBM12B RBM10

9.87e-03230684PS50102
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1B CACNA1C

6.00e-0611483M47958
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B CACNA1C

6.25e-0523483M47666
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT6A KRT6B KRT6C KRT77 PKP2

7.42e-05129485M27649
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1B CACNA1C

8.08e-0525483M47948
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1B CACNA1C

1.69e-046482M47762
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT6A KRT6B KRT77 PKP2

2.14e-0487484MM15351
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGHV3-33 IGHV3-30 IGHV3-20

2.25e-0435483MM17219
PathwayREACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION

IGHV3-33 IGHV3-30 IGHV3-20

3.11e-0439483MM17212
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGHV3-33 IGHV3-30 IGHV3-20

4.76e-0445483MM14912
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1A CACNA1B CACNA1C

5.41e-0447483M19708
PathwayREACTOME_FCGR_ACTIVATION

IGHV3-33 IGHV3-30 IGHV3-20

5.75e-0448483MM17214
PathwayWP_PANCREATIC_CANCER_SUBTYPES

KRT6A MYO1A KRT6C

5.75e-0448483M48093
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B

6.12e-0411482MM14498
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B

6.12e-0411482M26913
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGHV3-33 IGHV3-30 IGHV3-20

7.70e-0453483MM15716
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGHV3-33 IGHV3-30 IGHV3-20

8.14e-0454483MM14655
PathwayREACTOME_KERATINIZATION

KRT6A KRT6B KRT6C KRT77 PKP2

8.25e-04217485M27640
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGHV3-33 IGHV3-30 IGHV3-20

9.05e-0456483MM14815
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGHV3-33 IGHV3-30 IGHV3-20

1.00e-0358483MM14914
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGHV3-33 IGHV3-30 IGHV3-20

1.11e-0360483MM14913
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

IGHV3-33 IGHV3-30 IGHV3-20

1.11e-0360483MM14872
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

KRT6A KRT6B ARHGEF28 KRT77 PKP2 COL6A5 PLXNB1

1.45e-03502487MM14537
PathwayREACTOME_KERATINIZATION

KRT6A KRT6B KRT77 PKP2

1.79e-03153484MM15343
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

CACNA1C DES PKP2

2.03e-0374483M39462
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

CACNA1C DES PKP2

2.03e-0374483M16376
PathwayREACTOME_COMPLEMENT_CASCADE

IGHV3-33 IGHV3-30 IGHV3-20

2.91e-0384483MM14653
Pubmed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.

KRT6A KRT6B KRT6C

9.63e-09375329357356
Pubmed

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

KRT6A KRT6B KRT6C

9.63e-0937537543104
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B CACNA1C

9.63e-09375326507659
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B CACNA1C

3.85e-08475315728831
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B CACNA1C

3.85e-08475315953418
Pubmed

TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.

KRT6A KRT6B IGF2BP3 KRT77 HRNR FLG2

4.73e-089175634445801
Pubmed

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

DES KRT6A KRT6B

9.60e-08575323075894
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B CACNA1C

9.60e-08575311296258
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B CACNA1C

9.60e-08575316787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B CACNA1C

9.60e-08575315451373
Pubmed

Pachyonychia Congenita

KRT6A KRT6B KRT6C

9.60e-08575320301457
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

KRT6B RBM10 KRT77 HRNR FLG2

1.19e-075475535474131
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

KRT6A KRT6B KRT6C KRT77 HRNR FLG2

1.25e-0710775632989256
Pubmed

Frizzled6 deficiency disrupts the differentiation process of nail development.

KRT6A KRT6B HRNR

3.35e-07775323439395
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1C

8.02e-07975316382099
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

KRT6A KRT6B FBXW8 IGF2BP3 KRT77 HRNR FLG2

1.04e-0624575735652658
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

KRT6A KRT6B KRT77 HRNR FLG2

1.10e-068475529563501
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

IGF2BP3 CDK13 CLK3 RBM10 DNAJB6 PKP2 GIGYF2 CCT7 NKAP SPTY2D1

1.97e-06678751030209976
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

KRT6A KRT6B RBM10 KRT77 DNAJB6 CCT7 COL6A5 HRNR FLG2

3.24e-0655875927591049
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B CACNA1C

4.30e-061575320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B CACNA1C

4.30e-061575324453333
Pubmed

1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.

IGHV3-33 IGHV3-30 IGHV3-20

4.30e-061575312657787
Pubmed

Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum.

CACNA1A GRID2

4.59e-06275221628556
Pubmed

A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.

CACNA1A CACNA1C

4.59e-06275230733149
Pubmed

L-type calcium channels contribute to the tottering mouse dystonic episodes.

CACNA1A CACNA1C

4.59e-0627529882694
Pubmed

A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.

KRT6A KRT6B

4.59e-06275211118885
Pubmed

Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.

KRT6A KRT6B

4.59e-06275211489919
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

4.59e-06275223426690
Pubmed

Delayed wound healing in keratin 6a knockout mice.

KRT6A KRT6B

4.59e-06275210866680
Pubmed

Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa.

KRT6A KRT6B

4.59e-06275210953016
Pubmed

The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins.

KRT6A KRT6B

4.59e-0627526207530
Pubmed

Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.

KRT6A KRT6B

4.59e-06275210550543
Pubmed

The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis.

KRT6A KRT6B

4.59e-06275210550545
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

4.59e-06275238155373
Pubmed

Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC.

DES PKP2

4.59e-06275235959657
Pubmed

Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

KRT6A KRT6B

4.59e-06275223006328
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

4.59e-06275215050706
Pubmed

The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs.

KRT6A KRT6B

4.59e-0627529790766
Pubmed

Associations of Variants in the CACNA1A and CACNA1C Genes With Longitudinal Blood Pressure Changes and Hypertension Incidence: The GenSalt Study.

CACNA1A CACNA1C

4.59e-06275227418245
Pubmed

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.

KRT6A KRT6C

4.59e-06275223662636
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

4.59e-06275223376566
Pubmed

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.

CACNA1B CACNA1C

4.59e-06275222590648
Pubmed

Comprehensive analysis of keratin gene clusters in humans and rodents.

KRT6A KRT6B KRT77

5.29e-061675315085952
Pubmed

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.

KRT6A KRT6B KRT6C KRT77

7.22e-065775431862882
Pubmed

A functional reference map of the RNF8 interactome in cancer.

KRT6A KRT6B KRT77 NFXL1 HRNR FLG2

7.95e-0621875635831895
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

KRT6B IGF2BP3 KRT6C RBM10 GIGYF2 CCT7 HRNR FLG2 NPM3

9.87e-0664175936057605
Pubmed

New consensus nomenclature for mammalian keratins.

KRT6A KRT6B KRT6C KRT77

1.08e-056375416831889
Pubmed

Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome.

CACNA1C DES

1.37e-05375228427417
Pubmed

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

HRNR FLG2

1.37e-05375223403047
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

1.37e-05375238996073
Pubmed

Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.

KRT6A KRT6B

1.37e-05375217170733
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

1.37e-05375229466725
Pubmed

Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.

KRT6A KRT6B

1.37e-05375215601842
Pubmed

Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.

KRT6A KRT6B

1.37e-05375217851587
Pubmed

Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.

KRT6A KRT6B

1.37e-05375229587848
Pubmed

Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.

CACNA1A CACNA1C

1.37e-05375226216687
Pubmed

A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation.

KRT6A KRT6B

1.37e-05375214573483
Pubmed

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.

KRT6A KRT6B

1.37e-05375232213122
Pubmed

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair.

KRT6A KRT6B

1.37e-05375214568992
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B

1.37e-05375224523520
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

1.37e-05375224394417
Pubmed

Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network.

CACNA1A GRID2

1.37e-05375229166599
Pubmed

Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.

KRT6A KRT6B

1.37e-0537521713533
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

1.37e-05375229208674
Pubmed

Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse.

CACNA1A CACNA1C

1.37e-05375219422811
Pubmed

Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.

CACNA1A CACNA1C

1.37e-05375223338940
Pubmed

Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.

CACNA1A CACNA1C

1.37e-05375229581247
Pubmed

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

IGHV3-33 IGHV3-30 IGHV3-20

1.44e-05227532499654
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

DES FBXW8 MYO1A SH3TC1 ING1 SNX17 DVL2 NFXL1 HRNR CREM

1.53e-05857751025609649
Pubmed

Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.

KRT6A KRT6B KRT6C RBM10

2.16e-057575431527668
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B

2.75e-05475232616470
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

2.75e-05475226283199
Pubmed

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.

CACNA1B CACNA1C

2.75e-05475219065143
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B

2.75e-05475237141091
Pubmed

Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization.

CACNA1A GRID2

2.75e-05475222279216
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

2.75e-05475231253182
Pubmed

N-Acetylglucosaminyl transferase regulates the expression of the sulfoglucuronyl glycolipids in specific cell types in cerebellum during development.

CACNA1A GRID2

2.75e-0547528910533
Pubmed

Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.

KRT6A KRT6C

2.75e-0547529054461
Pubmed

Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.

CACNA1A CACNA1C

2.75e-05475221788606
Pubmed

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

KRT6A KRT6B

2.75e-05475230389720
Pubmed

Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei.

CACNA1A GRID2

2.75e-0547529514513
Pubmed

Regional expression of L-type calcium channel subunits during cardiac development.

CACNA1C DES

2.75e-05475215108317
Pubmed

A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.

KRT6A KRT6B

2.75e-05475222264670
Pubmed

Mouse models in preclinical studies for pachyonychia congenita.

KRT6A KRT6B

2.75e-05475216250208
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

2.75e-05475225483588
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

KRT6A KRT6B IGHV3-33 IGF2BP3 RBMXL3 KRT6C CDK13 KRT77 CCT7 HRNR NPM3

3.56e-051153751129845934
Pubmed

Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.

CACNA1B KRT6A KRT6B

4.57e-053275319320717
Pubmed

Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.

KRT6A KRT6B

4.57e-0557521713141
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B

4.57e-0557528825650
Pubmed

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

KRT6A KRT6B

4.57e-05575238693267
Pubmed

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.

DES PKP2

4.57e-05575216917092
Pubmed

Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells.

KRT6A KRT6B

4.57e-05575231898934
Pubmed

Role for keratins 6 and 17 during wound closure in embryonic mouse skin.

KRT6A KRT6B

4.57e-05575212557214
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

KRT6A KRT6B IGF2BP3 KRT6C RBM10 KRT77 HRNR FLG2

4.85e-0560575828977666
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CACNA1C DES KRT6A KRT6B KHDRBS3 MYO1A KRT6C CDK13 KRT77 DNAJB6 NFXL1 TOP1MT

5.73e-051442751235575683
Pubmed

Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.

CACNA1B CACNA1C

6.84e-05675216029198
Pubmed

p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

KRT6A KRT6B

6.84e-05675225383540
Pubmed

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.

CACNA1B CACNA1C

6.84e-05675211438518
Pubmed

Keratin 6 is not essential for mammary gland development.

KRT6A KRT6B

6.84e-05675216790075
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B

6.84e-05675235324301
InteractionKRT84 interactions

DES KRT6A KRT6B KRT6C KRT77

7.95e-0749715int:KRT84
InteractionKRT17 interactions

DES KRT6A KRT6B IGF2BP3 KRT6C KRT77 HRNR FLG2

2.88e-06252718int:KRT17
InteractionRNF208 interactions

KRT6A KRT6B RPIA KRT6C KRT77

6.70e-0675715int:RNF208
InteractionKRT25 interactions

KRT6A KRT6B KRT6C KRT77

6.82e-0635714int:KRT25
InteractionSCN11A interactions

CACNA1A CACNA1B CACNA1C

1.85e-0515713int:SCN11A
InteractionDES interactions

DES KRT6A KRT6B KRT6C KRT77 CCT7

1.99e-05158716int:DES
InteractionPHTF1 interactions

KRT6A KRT6B KRT6C

4.58e-0520713int:PHTF1
InteractionSCN9A interactions

CACNA1A CACNA1B CACNA1C

5.32e-0521713int:SCN9A
InteractionKRT13 interactions

DES KRT6A KRT6B KRT6C DNAJB6

5.57e-05116715int:KRT13
InteractionKRT5 interactions

DES KRT6A KRT6B KRT6C KRT77 PKP2

6.10e-05193716int:KRT5
InteractionCACNB2 interactions

CACNA1A CACNA1B CACNA1C

7.05e-0523713int:CACNB2
InteractionKRT20 interactions

DES KRT6A KRT6B KRT6C

7.20e-0563714int:KRT20
InteractionCACNA1A interactions

CACNA1A CACNA1B CACNA1C KHDRBS3 RBM12B

7.36e-05123715int:CACNA1A
InteractionKRT12 interactions

DES KRT6A KRT6B

8.04e-0524713int:KRT12
InteractionCACNA1D interactions

CACNA1A CACNA1B CACNA1C

8.04e-0524713int:CACNA1D
InteractionCACNB4 interactions

CACNA1A CACNA1B CACNA1C

9.12e-0525713int:CACNB4
InteractionKHDRBS2 interactions

IGF2BP3 KHDRBS3 RBM10 DDX43 HRNR

9.23e-05129715int:KHDRBS2
InteractionKRT36 interactions

KRT6A KRT6B KRT6C KRT77

1.35e-0474714int:KRT36
InteractionSCN1A interactions

CACNA1A CACNA1B CACNA1C

1.43e-0429713int:SCN1A
InteractionKRT28 interactions

KRT6A KRT6B KRT6C

1.59e-0430713int:KRT28
InteractionKRT7 interactions

KRT6A KRT6B KRT6C KRT77

1.83e-0480714int:KRT7
InteractionCACNB3 interactions

CACNA1A CACNA1B CACNA1C

1.93e-0432713int:CACNB3
InteractionCYLD interactions

KRT6A KRT6B RBM10 KRT77 DNAJB6 MUC19 GIGYF2 CCT7 COL6A5 HRNR FLG2

2.14e-048687111int:CYLD
InteractionKIF23 interactions

DES IGHV3-33 IGF2BP3 RBMXL3 MYO1A RBM12B PKP2 HRNR TOP1MT FLG2 SPTY2D1 INO80B

2.36e-0410317112int:KIF23
InteractionKRT6A interactions

DES KRT6A KRT6B KRT6C KRT77

2.53e-04160715int:KRT6A
InteractionKRT26 interactions

KRT6A KRT6B KRT6C

2.53e-0435713int:KRT26
InteractionCACNA1B interactions

CACNA1A CACNA1B CACNA1C

2.99e-0437713int:CACNA1B
InteractionKRT33B interactions

DES KRT6B KRT6C KRT77

3.26e-0493714int:KRT33B
InteractionHEXIM1 interactions

KRT6A KRT6B IGHV3-33 IGF2BP3 KRT6C CDK13 CLK3 KRT77 CCT7 HRNR NPM3

3.30e-049137111int:HEXIM1
InteractionDCAF4 interactions

SOWAHA CCDC9B RBM12B DNAJB6 PKP2 CCT7 DDX43

3.66e-04378717int:DCAF4
InteractionZUP1 interactions

KRT6A KRT6B KRT77 HRNR FLG2

3.72e-04174715int:ZUP1
InteractionKRT15 interactions

DES KRT6A KRT6B KRT6C KRT77

4.13e-04178715int:KRT15
Cytoband12q13.13

KRT6A KRT6B KRT6C KRT77

4.66e-066775412q13.13
Cytoband14q32.33

IGHV3-33 IGHV3-30 IGHV3-20 IGHV3-30-5 IGHV3-30-3

3.76e-0522875514q32.33
Cytoband2p13.2

FBXO41 CCT7

1.72e-04127522p13.2
Cytoband10p11.21

CREM GJD4

4.42e-041975210p11.21
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT6A KRT6B MYO1A KRT6C KRT77

6.59e-04423755chr12q13
CytobandEnsembl 112 genes in cytogenetic band chr2p13

FBXO41 CCT7 INO80B

1.60e-03140753chr2p13
GeneFamilyKeratins, type II

KRT6A KRT6B KRT6C KRT77

1.94e-0627614609
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B CACNA1C

8.99e-0526613253
GeneFamilyADAMTS like

THSD4 ADAMTSL1

2.33e-047612947
GeneFamilyEF-hand domain containing|S100 fused type protein family

HRNR FLG2

2.33e-0476121350
GeneFamilyImmunoglobulin heavy locus at 14q32.33

IGHV3-33 IGHV3-30 IGHV3-20 IGHV3-30-5 IGHV3-30-3

4.18e-04187615349
GeneFamilyRNA binding motif containing

IGF2BP3 RBMXL3 RBM12B RBM10

5.79e-03213614725
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6|TCGA-Bladder / Sample_Type by Project: Shred V9

KRT6A KRT6B CELSR2 KRT6C SH3RF2 LTB4R

3.81e-071717360e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHLDB3 KRT6A KRT6B ARHGEF28 CELSR2 GIGYF2

7.96e-07194736a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5|TCGA-Lung / Sample_Type by Project: Shred V9

KRT6A KRT6B CELSR2 KRT6C LTB4R

1.08e-05177735a0c7d08469c513cecf87777c19876884f1511570
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRT6A KRT6B KRT6C SH3RF2 FLG2

1.40e-051877352ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCellTCGA-Skin-Primary_Tumor|TCGA-Skin / Sample_Type by Project: Shred V9

KRT6A KRT6B KRT6C SH3RF2 FLG2

1.52e-05190735e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCellTCGA-Skin-Primary_Tumor-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KRT6A KRT6B KRT6C SH3RF2 FLG2

1.52e-0519073501fb45add4661bc86cd0a34fac35177907152dbb
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KRT6A KRT6B KRT6C SH3RF2 FLG2

1.52e-051907353188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 CACNA1C DES ADAMTSL1 ATOH8

1.56e-051917358597a8af294f24496c317d995f07eb5dcc25c13c
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CACNA1A ADAMTSL1 ARHGEF28 MUC19 FLG2

1.72e-05195735d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CACNA1A ADAMTSL1 ARHGEF28 MUC19 FLG2

1.72e-0519573519853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT6A KRT6B KRT6C DNAJB6 CREM

1.89e-051997358be7cb9d8b4f9707efb69c681c40e683fcd810e5
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1A CACNA1B GRID2 C10orf90

5.84e-0512873491072ca56bce2c552a95edd67e17f43d8cc1de95
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1|Hippocampus / BrainAtlas - Mouse McCarroll V32

THSD4 ARHGEF28 KRT77 PKP2

6.21e-05130734c70fb77324916d220d842a575558a8245c276599
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

SOWAHA ARHGEF28 KRT77 PKP2

9.23e-05144734e2a2f260f5ebaaef46248d199c407a15ce9d024a
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1A CACNA1B ADAMTSL1 GRID2

1.03e-04148734d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

DES CCDC9B CELSR2 IQCJ-SCHIP1

1.17e-04153734ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B MYO1A COL6A5 FLG2

1.23e-041557348fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma|TCGA-Bladder / Sample_Type by Project: Shred V9

MZF1 CLK3 ATOH8 PLXNB1

1.32e-04158734dc559503bab3ec1b9ea54ef2e896d1be33e5344c
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A CACNA1B ADAMTSL1 GRID2

1.35e-041597345335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A IGF2BP3 GRID2 GJD4

1.49e-0416373419c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHLDB3 LIX1L PKDREJ PLXNB1

1.49e-04163734132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF28 SH3TC1 PKP2 INPP5J

1.52e-04164734d847d509bb1791638032ade6755d8164586b5bd5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A ING1 MUC19 NPM3

1.60e-04166734c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A CACNA1B IGF2BP3 GRID2

1.63e-041677343edb0570e583bb527165bcd8a4c25a042054043b
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF28 SH3RF2 ATOH8 PKP2

1.63e-041677349f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF28 SH3RF2 ATOH8 PKP2

1.63e-04167734bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A KHDRBS3 MZF1 LTB4R

1.63e-04167734f5bffa77061baec0ba87bd688a047595f32534db
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1A IGHV3-33 IGHV3-30 IGHV3-20

1.71e-04169734307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1A IGHV3-33 IGHV3-30 CLEC20A

1.75e-04170734ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1A IGHV3-33 IGHV3-30 CLEC20A

1.75e-04170734d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCellBAL-Mild-Lymphocyte-B-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1A IGHV3-33 IGHV3-30 CLEC20A

1.75e-0417073452787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCellTCGA-Head_and_Esophagus|World / Sample_Type by Project: Shred V9

KRT6A KRT6B KRT6C LTB4R

1.83e-04172734eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT6A KRT6B SOWAHA SH3RF2

1.91e-0417473497d4a40b536a67fa52f055eab26106d041bf3220
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT6A KRT6B SOWAHA SH3RF2

1.91e-04174734f9f399244c7d12caf8118ec3117d477a39e35c3b
ToppCellPND10-Epithelial-Epithelial_Airway-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT6A KRT6B SOWAHA SH3RF2

1.91e-04174734e8440eea7c81864defa57c89e9b569ad8033e5c5
ToppCellfacs-Heart-LV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES ADAMTSL1 SOWAHA PLXNB1

1.91e-041747342eee7b5471672b439f95eba11494c2adf8cb7006
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT6A SH3RF2 LTB4R PLXNB1

1.91e-04174734207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellfacs-Heart-LV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES ADAMTSL1 SOWAHA PLXNB1

1.91e-04174734197686570cec6d96a92e77e6409325d3bfe6f991
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD4 ADAMTSL1 KHDRBS3 IQCJ-SCHIP1

1.91e-04174734b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A FBXW8 SH3RF2 PKP2

1.95e-0417573496219e58dcb327fd27190be78193e7a0d611e62b
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A FBXW8 SH3RF2 PKP2

1.95e-04175734cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT6A KRT6B CELSR2 SH3RF2

2.00e-041767348d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES ADAMTSL1 SOWAHA PLXNB1

2.04e-04177734dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES ADAMTSL1 SOWAHA PLXNB1

2.08e-04178734416f85e51f45ec7949451fd47611a84e33e87245
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 DES ADAMTSL1 PLXNB1

2.17e-04180734dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

THSD4 CACNA1C DES ADAMTSL1

2.17e-04180734d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2BP3 KHDRBS3 ATOH8 NFXL1

2.17e-041807345b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 DES ADAMTSL1 PLXNB1

2.17e-041807340059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 GRID2 C10orf90 ATP10A

2.17e-041807348923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT6A KRT6B IGF2BP3 KRT6C

2.27e-04182734007fa56ed8b91f9af0df2114c00410b2f6cec8b6
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

CACNA1A CACNA1C ARHGEF28 ATP10A

2.32e-04183734818fd886e0188091310825f9145fa53328f2c979
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES CCDC9B ZNF276 LIX1L

2.32e-04183734ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C DES PKP2 IQCJ-SCHIP1

2.32e-041837342902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

THSD4 CACNA1C KRT6A SH3RF2

2.32e-04183734dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 KRT6A CELSR2 COL6A5

2.32e-0418373499ab7a43527eb226027efbcd8c0b6a8e46fc3c93
ToppCellMild_COVID-19-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CACNA1A IGHV3-33 IGHV3-30 IGHV3-20

2.32e-04183734dea119e2988e954475f557f0bbe12556a83e81a4
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 KRT6A CELSR2 COL6A5

2.32e-0418373428916f0597690ff534578be2cb715b485cb1de1a
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

CACNA1A CACNA1C ARHGEF28 ATP10A

2.32e-04183734cae2ee08f985a6f005b4b8e959e465350315156a
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

THSD4 CACNA1C DES PKP2

2.36e-04184734ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD4 CACNA1C DES PKP2

2.41e-04185734549eeb521c3985bff396ea0f202db21822efa51f
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

THSD4 SH3RF2 IQCJ-SCHIP1 ATP10A

2.41e-0418573432b4e68e551d435a732f253f6ad83408c759a642
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES ADAMTSL1 SOWAHA PLXNB1

2.41e-0418573430df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

THSD4 CACNA1C DES PKP2

2.41e-041857346baccb26f999145e51b91d94315bf8d4655bef31
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 CACNA1C DES GRID2

2.46e-041867346add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCelldroplet-Fat-SCAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR2 PKP2 INPP5J PLXNB1

2.51e-041877345fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DES ADAMTSL1 SOWAHA PLXNB1

2.51e-041877348ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCelldroplet-Fat-SCAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR2 PKP2 INPP5J PLXNB1

2.51e-04187734766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCelldroplet-Fat-SCAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR2 PKP2 INPP5J PLXNB1

2.51e-04187734f49d06600060deeb2fc1b1da5b93496535f20104
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 CACNA1C DES GRID2

2.57e-04188734293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellLV-14._Fibroblast_III|World / Chamber and Cluster_Paper

PHLDB3 KHDRBS3 GRID2 CREM

2.62e-041897343922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCelldroplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 CACNA1C DES ADAMTSL1

2.62e-04189734a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

THSD4 SH3RF2 PKP2 IQCJ-SCHIP1

2.62e-041897349c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

KRT6A KRT6B KRT6C LTB4R

2.62e-04189734533c302df467d13ab639232daf4f8cafb808260b
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 CACNA1C DES GRID2

2.62e-041897347ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 CACNA1C DES GRID2

2.62e-0418973445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

KRT6A KRT6B CELSR2 KRT6C

2.62e-04189734aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPIA ARHGEF28 TOP1MT NPM3

2.67e-0419073436e83995021ba16690f84e2077a9e8baec547d05
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPIA ARHGEF28 TOP1MT NPM3

2.67e-04190734d26be9e1b676f750e716b91ebc3598fac3735612
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 CACNA1C COL6A5 GRID2

2.72e-0419173414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

THSD4 CACNA1C DES PKP2

2.72e-041917345d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 CACNA1C DES GRID2

2.72e-04191734b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 CACNA1C DES ADAMTSL1

2.78e-041927343617d2bc7e33d981f3ec349e9962d8d4bd822fbd
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 DES ADAMTSL1 PLXNB1

2.83e-041937341043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 DES ADAMTSL1 PLXNB1

2.83e-041937340266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

THSD4 CACNA1C PKP2 IQCJ-SCHIP1

2.83e-04193734dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 DES ADAMTSL1 ATOH8

2.89e-0419473480be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

THSD4 CACNA1C PKP2 IQCJ-SCHIP1

2.89e-04194734c3535f7cc0076653c72db582047cff053c322397
ToppCell(10)_Ciliated-(0)_Reference|(10)_Ciliated / shred by cell type by condition

SNX17 CCT7 PLXNB1 GJD4

2.89e-04194734f9d5bf6baddbd88947e6a740805962109649ed3b
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

THSD4 CACNA1C DES PKP2

2.95e-0419573475fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT6A SH3RF2 PKP2 LTB4R

3.06e-041977341e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT6A KRT6B KRT6C LTB4R

3.06e-041977342430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C DES MYO1A IQCJ-SCHIP1

3.06e-04197734ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PHLDB3 KRT6A KRT6B KRT6C

3.06e-04197734d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT6A KRT6B SH3RF2 LTB4R

3.12e-0419873477517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT6A KHDRBS3 SH3RF2 LTB4R

3.12e-04198734fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C DES ADAMTSL1 WDR87

3.18e-04199734b768496381362f9a2706e0892b5a7a0db82e09ce
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Proliferative_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

DES KHDRBS3 CELSR2 NFKBIE

3.18e-04199734eb5971660dff356721a004f821d52a5b7a33c951
ToppCelldistal-1-Epithelial-Proliferating_Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT6A KRT6B IGF2BP3 KRT6C

3.18e-0419973493450257180d918c310bca7b5defc74390c48091
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

DES KHDRBS3 COL6A5 NPM3

3.24e-04200734ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCellNeuronal-Excitatory-eG(DAPK2)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

ADAMTSL1 GRID2 C10orf90 ATP10A

3.24e-042007347cea58e2691564e653cc972bf5aaff2df1f2666e
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

KRT6A KRT6B KRT6C

5.58e-0450353GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI3
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

KRT6A KRT6B KRT6C

5.58e-0450353GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPISEN
DrugSC-791

KRT6A KRT6B KRT6C

5.06e-076683CID010291510
DrugDoxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; HL60; HT_HG-U133A

CACNA1A ZNF276 CELSR2 DDX43 LTB4R CREM INO80B

1.96e-061966872737_DN
DrugAC1L1JG6

CACNA1A CACNA1B CACNA1C

9.06e-0614683CID000005026
Drugbutamben

CACNA1A CACNA1B CACNA1C

1.13e-0515683CID000002482
DrugVerapamil

CACNA1A CACNA1B CACNA1C

1.39e-0516683DB00661
Drugmant-GTP

KRT6A KRT6B KRT6C CREM

1.51e-0550684CID000128647
Drugclobestasol propionate

KRT6A KRT6B KRT6C

1.68e-0517683CID000002791
DrugCD-III

DES KRT6A KRT6B KRT6C

1.91e-0553684CID000066693
Drugdithranol

KRT6A KRT6B KRT6C

2.01e-0518683CID000002202
Drugcignolin

KRT6A KRT6B AHRR KRT6C

2.38e-0556684CID000010187
DrugHarmine hydrochloride [343-27-1]; Up 200; 16uM; PC3; HT_HG-U133A

ING1 CDK13 CLK3 CREM INPP5J INO80B

2.50e-051946865855_UP
DrugPyrithyldione [77-04-3]; Up 200; 24uM; MCF7; HT_HG-U133A

ARHGEF28 CELSR2 ATP10A CREM INPP5J INO80B

2.72e-051976866801_UP
DrugOlux

KRT6A KRT6B KRT6C

2.80e-0520683CID000032797
DrugN1-acetylspermidine

KRT6A KRT6B KRT6C

2.80e-0520683CID000000496
DrugPhensuximide [86-34-0]; Up 200; 21.2uM; MCF7; HT_HG-U133A

DES KRT6B ARHGEF28 CDK13 PLXNB1 INO80B

2.80e-051986865522_UP
DrugNSC759256

CACNA1A CACNA1C RPIA CREM

3.80e-0563684CID000125889
DrugMK-6

KRT6A KRT6B KRT6C

4.93e-0524683CID005283547
DrugAC 110

CACNA1A CACNA1B

5.25e-054682CID000022860
DrugBhg-(2-1)fuc

KRT6A KRT6B KRT6C

5.59e-0525683CID005287784
Drugethosuximide

CACNA1A CACNA1B CACNA1C CREM

7.15e-0574684CID000003291
Drugbetamethasone valerate

KRT6A KRT6B KRT6C

7.91e-0528683CID000016533
DrugS 8510

CACNA1A CACNA1B

8.74e-055682CID005488383
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1A CACNA1B CACNA1C CREM

9.24e-0579684CID005287890
Drugplakin

DES KRT6A KRT6B KRT6C

1.07e-0482684CID000018752
Drug2-Formyl-Protoporphryn Ix

KRT6A KRT6B KRT6C

1.08e-0431683CID011963946
DrugAGN 193109

KRT6A KRT6B KRT6C

1.08e-0431683CID000177238
Drug4,4'-thiodiphenol

KRT6A KRT6B KRT6C

1.19e-0432683CID000017570
DrugCNS 1145

CACNA1A CACNA1B CACNA1C

1.30e-0433683CID000190902
DrugIHC-64

CACNA1A CACNA1B CACNA1C

1.30e-0433683CID000162753
Drug3,4-dihydroquinazoline

CACNA1A CACNA1B

1.31e-046682CID000583065
Drugalpha-sialylcholesterol

CACNA1A CACNA1B

1.31e-046682CID000133976
Drugal-Badry

KRT6A KRT6B KRT6C KRT77 TOP1MT

1.36e-04165685CID000004545
DrugAmlodipine

CACNA1B CACNA1C

1.83e-047682DB00381
DrugAPMPA

CACNA1A CACNA1B

1.83e-047682CID000512300
Drugchrysarobin

KRT6A KRT6B KRT6C

1.84e-0437683CID000068111
Drugtsuwabukinonol

KRT6A KRT6B KRT6C

1.84e-0437683CID006440419
Drug1-EBIO

CACNA1A CACNA1B CACNA1C

1.84e-0437683CID000082320
Drugmanidipine

CACNA1A CACNA1B CACNA1C DES

1.89e-0495684CID000004008
DrugCaLam

KRT6A KRT6B KRT6C

2.16e-0439683CID004126474
Drug0297417-0002B [362658-29-5]; Up 200; 10uM; MCF7; HT_HG-U133A

DES ZNF276 SH3TC1 MZF1 INPP5J

2.43e-041876856902_UP
DrugPregnenolone [145-13-1]; Down 200; 12.6uM; HL60; HT_HG-U133A

CACNA1A ZNF276 DVL2 DDX43 CREM

2.55e-041896852497_DN
DrugAC1L9MJT

DES KRT6A KRT6B KRT6C KRT77

2.74e-04192685CID000448959
DrugProguanil hydrochloride [637-32-1]; Down 200; 13.8uM; MCF7; HT_HG-U133A

ING1 MZF1 DVL2 PLXNB1 INO80B

2.74e-041926853505_DN
Drugloperamide

CACNA1A CACNA1B CACNA1C TOP1MT

2.77e-04105684CID000003954
DrugIsoetharine mesylate salt [7279-75-6]; Down 200; 12uM; HL60; HT_HG-U133A

ZNF276 KHDRBS3 CELSR2 ATP10A INO80B

2.88e-041946852711_DN
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; HL60; HT_HG-U133A

DES CELSR2 ING1 ATP10A CREM

2.95e-041956852454_DN
DrugGentamicine sulfate [1405-41-0]; Down 200; 2.6uM; MCF7; HT_HG-U133A

CACNA1A ARHGEF28 MZF1 INO80B NPM3

2.95e-041956852245_DN
DrugLiothyronine [6893-02-3]; Down 200; 6.2uM; MCF7; HT_HG-U133A

ZNF276 MZF1 DVL2 INO80B NPM3

2.95e-041956854947_DN
Drug(S)-propranolol hydrochloride [4199-10-4]; Up 200; 13.6uM; HL60; HT_HG-U133A

CACNA1A DES ZNF276 CREM INO80B

3.02e-041966852961_UP
DrugDiphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; PC3; HT_HG-U133A

ZNF276 SH3TC1 MZF1 LTB4R INO80B

3.02e-041966854591_DN
DrugClindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; MCF7; HT_HG-U133A

DES KRT6B ING1 LTB4R INO80B

3.02e-041966852219_DN
DrugTenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ARHGEF28 KHDRBS3 DVL2 FBXO41 INPP5J

3.02e-041966854182_DN
DrugCiprofloxacin hydrochloride [93107-08-5]; Down 200; 10.8uM; PC3; HG-U133A

KRT6B ING1 RBM10 DNAJB6 CREM

3.02e-041966851939_DN
DrugSulfanilamide [63-74-1]; Down 200; 23.2uM; HL60; HT_HG-U133A

ZNF276 KHDRBS3 DVL2 CREM INO80B

3.09e-041976852709_DN
DrugLevodopa [59-92-7]; Up 200; 20.2uM; MCF7; HT_HG-U133A

CACNA1A ARHGEF28 CDK13 PKP2 ATP10A

3.09e-041976854394_UP
DrugPhentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; PC3; HT_HG-U133A

KRT6B CELSR2 ING1 LTB4R INO80B

3.09e-041976854336_DN
DrugEdrophonium chloride [116-38-1]; Up 200; 19.8uM; MCF7; HT_HG-U133A

THSD4 DES KRT6B ING1 NPM3

3.09e-041976855001_UP
DrugRoxarsone [121-19-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A

DES KRT6B ARHGEF28 ING1 MZF1

3.16e-041986855470_UP
DrugEthoxyquin [91-53-2]; Down 200; 18.4uM; PC3; HT_HG-U133A

SH3TC1 ING1 CREM INO80B NPM3

3.16e-041986853764_DN
DrugGalanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

THSD4 CACNA1A DES KHDRBS3 CDK13

3.24e-041996852787_UP
DrugRifampicin [13292-46-1]; Down 200; 4.8uM; PC3; HT_HG-U133A

DES ZNF276 MZF1 INO80B NPM3

3.24e-041996854008_DN
DrugLevocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; MCF7; HT_HG-U133A

ZNF276 MZF1 NFKBIE CREM INO80B

3.24e-041996857009_DN
DrugSulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; HL60; HT_HG-U133A

CACNA1A DES ING1 CREM NPM3

3.24e-041996852550_DN
DrugHomosalate [118-56-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A

ING1 CDK13 FBXO41 LTB4R PLXNB1

3.24e-041996853879_DN
DrugNalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; PC3; HT_HG-U133A

DES KRT6B DVL2 INPP5J INO80B

3.24e-041996855820_UP
Drugfelodipine; Down 200; 10uM; MCF7; HG-U133A

ZNF276 KHDRBS3 CDK13 DVL2 PLXNB1

3.24e-04199685337_DN
DrugBiperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; MCF7; HT_HG-U133A

DES ING1 CDK13 DVL2 LTB4R

3.24e-041996855279_UP
Drugh PM

CACNA1A CACNA1B CACNA1C

3.31e-0445683CID005494424
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; PC3; HT_HG-U133A

SH3TC1 ING1 CDK13 PLXNB1 INO80B

3.31e-042006852077_UP
DrugPimethixene maleate [13187-06-9]; Up 200; 9.8uM; HL60; HT_HG-U133A

KRT6B CELSR2 DDX43 ATP10A CREM

3.31e-042006852395_UP
Drugestradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A

ING1 DVL2 INPP5J PLXNB1 INO80B

3.31e-042006851666_DN
DiseaseMUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1E

DES DNAJB6

4.93e-062662C3148763
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

1.48e-053662DOID:0111181 (implicated_via_orthology)
DiseasePachyonychia Congenita, Jadassohn Lewandowsky Type

KRT6A KRT6B

2.95e-054662C1706595
Diseasepachyonychia congenita (is_implicated_in)

KRT6A KRT6B

2.95e-054662DOID:0050449 (is_implicated_in)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

2.95e-054662DOID:6364 (implicated_via_orthology)
DiseasePachyonychia congenita syndrome

KRT6A KRT6B

2.95e-054662cv:C0265334
DiseasePachyonychia Congenita, Type 2 (disorder)

KRT6A KRT6B

2.95e-054662C1721007
DiseasePachyonychia Congenita

KRT6A KRT6B

4.91e-055662C0265334
Diseaseable to hear with hearing aids

AHRR ARHGEF28

1.03e-047662EFO_0009720
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

1.03e-047662DOID:0050951 (implicated_via_orthology)
DiseaseMuscular dystrophy, limb-girdle, autosomal dominant

DES DNAJB6

2.19e-0410662cv:C5675009
Diseasearrhythmogenic right ventricular cardiomyopathy (is_implicated_in)

DES PKP2

2.19e-0410662DOID:0050431 (is_implicated_in)
Diseasehearing loss

AHRR ARHGEF28 DVL2

4.62e-0467663EFO_0004238
Diseaseresponse to radiation

IGF2BP3 C10orf90 ATP10A

1.02e-0388663GO_0009314
DiseaseBrugada Syndrome (disorder)

CACNA1C PKP2

1.32e-0324662C1142166
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

CELSR2 SNX17 SPTY2D1

1.44e-0399663EFO_0004611, EFO_0007878
DiseaseLimb-girdle muscular dystrophy

DES DNAJB6

1.55e-0326662cv:C0686353
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

CELSR2 SNX17 SPTY2D1

1.57e-03102663EFO_0004329, EFO_0004611

Protein segments in the cluster

PeptideGeneStartEntry
SRASGVTGRRETPGP

AHRR

386

A9YTQ3
QGGSRESRSGSPRTG

CACNA1A

936

O00555
PGTSLLGRGARRSGE

CLK3

71

P49761
PCRSLGSRGRGSSGA

CELSR2

36

Q9HCU4
TSGASTPGRGGRRQL

CACNA1B

2176

Q00975
GHISTSTGRGRGRGL

CDK13

1496

Q14004
ESEPSSRGGSLRRGG

DVL2

621

O14641
VVPRGGSVSQRGSIG

ATP10A

471

O60312
KRTDRVGRGRPGSGT

RBM12B

86

Q8IXT5
VGRGRPGSGTSGVDS

RBM12B

91

Q8IXT5
QTRVRGSGLGARGSS

RBM10

891

P98175
VNSTGRRGRGTLGRP

KIAA0895L

86

Q68EN5
SPTASLVTGGREGRG

ARHGEF28

1321

Q8N1W1
PRGGTDTAGERGGSR

ATOH8

86

Q96SQ7
REGTRRGTEGSSGPA

PHLDB3

476

Q6NSJ2
TATSGGGGRTRREAP

DCHS1

2881

Q96JQ0
GLTTQTGSRTTGRRG

FLG2

1711

Q5D862
IQTGSRTTGRRGSGH

FLG2

1941

Q5D862
ISVSRSRGSGGLGGA

KRT6C

36

P48668
SGGGVVQPGRSLRLS

IGHV3-30-5

26

P0DP03
GLSGRPGGSETSARR

MCUR1

26

Q96AQ8
GRGRSRGRATAAPSG

NFXL1

11

Q6ZNB6
SRTRAGGVGGLRVPA

NPM3

16

O75607
VSVSRSRGSGGLGGA

KRT6A

36

P02538
SGIPASGIRDGRGVR

MYO1A

286

Q9UBC5
SGGGVVQPGRSLRLS

IGHV3-30-3

26

P0DP02
SGGAGPLSGSARRGR

NFKBIE

26

O00221
GGEGAGSPRRTSRVS

GJD4

271

Q96KN9
RTSSTGDAGGGSRRP

ADAMTSL1

1146

Q8N6G6
RPTRGGSQRSRGTAG

CCDC9B

506

Q6ZUT6
RGGGRGGRRNTTPSV

FAM104A

36

Q969W3
RSTAGTPRSGCGLTR

GRID2

121

O43424
SRSRSPLAREGAGGG

FBXW8

81

Q8N3Y1
RGPRAGGTRLTLNGS

PLXNB1

1171

O43157
ISVSRSRGSGGLGGA

KRT6B

36

P04259
GIRATRTEAPGGTSG

MUC19

6541

Q7Z5P9
GRQGSGSGHSPSRVR

HRNR

766

Q86YZ3
ISRLTGREGTGQPGR

PHRF1

711

Q9P1Y6
PGVGTSGRGTLRALR

LIX1L

11

Q8IVB5
SGRGTLRALRPGVTG

LIX1L

16

Q8IVB5
SGGGVVRPGGSLRLS

IGHV3-20

26

A0A0C4DH32
PVGRSGGGASARSSR

PRR25

261

Q96S07
RRGLGQRGSSRQGSP

IGF2BP3

171

O00425
RRGGSLGQTARSGPA

LTB4R

316

Q15722
RLTKTAATSGRGGRG

INO80B

241

Q9C086
RRGPRGSRSRGTGSF

DNAJB6

126

O75190
TTPGGGGSSAARRVR

CACNA1C

2081

Q13936
GTVVGAPRGRSSSRG

GIGYF2

111

Q6Y7W6
GSPSSRGSRGREGQR

COL6A5

1546

A8TX70
VSRTSGGAGGLGSLR

DES

56

P17661
SGGGVVQPGRSLRLS

IGHV3-30

26

P01768
GGSGRGRRAERVSPS

FBXO41

526

Q8TF61
AITRGRGGVTARPVG

KHDRBS3

201

O75525
RGVLSTRGPVSRGRG

KHDRBS3

226

O75525
SLRARPGSGASRGQG

ARRDC1-AS1

126

Q9H2J1
VSVAGSGTRRGSPAV

CREM

41

Q03060
GRTGRAGRTGVSITT

DDX43

576

Q9NXZ2
GSRSPDREASGSGGR

NKAP

6

Q8N5F7
SGGGVVQPGRSLRLS

IGHV3-33

26

P01772
VRLPGRAQSGTRGGA

RPIA

41

P49247
IPIGGGSRGAGRVSR

ING1

96

Q9UK53
PSAVRAGGAVLSGRG

PKDREJ

61

Q9NTG1
TVDAPTAAGRGRGRG

CCT7

526

Q99832
GPSGGGSTRDQVRTV

SH3TC1

21

Q8TE82
AGRAGRRGLDPTGTV

SKIV2L

701

Q15477
REPGDVSARTRSGGG

IQCJ-SCHIP1

196

B3KU38
GRSVSGPGRSISGSI

SPTY2D1

486

Q68D10
RPGRAVASVGSGTDR

CLEC20A

306

Q6ZU45
GGPRRGFASITITAR

C10orf90

131

Q96M02
SRGSRRPGTRAGLGS

INPP5J

6

Q15735
SGSTSSPGRGRGEVR

SNX17

331

Q15036
AGRGGPATARSRVSA

nan

66

Q96NJ1
VPRDRGGRGAGSQST

nan

56

Q6ZSN1
RAVPRSSLARIGGSG

RBMXL3

206

Q8N7X1
ATGGGSGSLAARRPV

SOWAHA

451

Q2M3V2
SDGGGGVSRTRGRPS

ZNF276

21

Q8N554
RGVPGSRRTQKGSGA

TOP1MT

26

Q969P6
RSTAGPGTLGQGSLR

SH3RF2

496

Q8TEC5
TGDRRSRTRGTIGPG

THSD4

151

Q6ZMP0
IQGRGASGISGRRST

WDR87

1221

Q6ZQQ6
PSTLGGQGGRITRSG

PKP2

481

Q99959
GSGRSGRGSSRVQII

KRT77

551

Q7Z794
SRTPAGRGAGTSARG

LRFN2

676

Q9ULH4
RSRGRPSTGGGVVRG

MZF1

341

P28698