Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.00e-07	279	96	11	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D3E GBF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.69e-06	507	96	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D3E GBF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.69e-06	507	96	12	GO:0030695
GeneOntologyMolecularFunction	enzyme regulator activity	TBC1D3E PPP2R2A PPP2R2B CLSTN3 PPP2R2C GBF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D CST2 CST4 ITPRIP ADGRV1 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.10e-05	1418	96	20	GO:0030234
GeneOntologyMolecularFunction	glutamine N-acyltransferase activity	GLYATL1 GLYATL1B	2.29e-05	2	96	2	GO:0047946
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	ASIC1 ASIC4 ASIC3	8.34e-05	18	96	3	GO:0015280
GeneOntologyMolecularFunction	pH-gated monoatomic ion channel activity	ASIC1 ASIC3	1.36e-04	4	96	2	GO:0160128
GeneOntologyMolecularFunction	glycine N-acyltransferase activity	GLYATL1 GLYATL1B	2.27e-04	5	96	2	GO:0047961
GeneOntologyMolecularFunction	enzyme activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.10e-04	656	96	11	GO:0008047
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.28e-12	109	93	11	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.32e-08	244	93	11	GO:0043547
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.28e-07	335	93	11	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D BCL2L2 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.48e-06	499	93	12	GO:0051345
GeneOntologyBiologicalProcess	regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D CST2 CST4 BCL2L2 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.75e-05	878	93	14	GO:0051336
GeneOntologyCellularComponent	manchette	MEIG1 IFT88 SPAG17 DYNC1H1	7.86e-06	28	96	4	GO:0002177
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2R2A PPP2R2B PPP2R2C	7.29e-05	18	96	3	GO:0000159
GeneOntologyCellularComponent	acrosomal vesicle	IFT88 PRAMEF19 PRAMEF18 SPAG17 KIT SPATA31C1	3.78e-04	206	96	6	GO:0001669
Domain	TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	4.46e-14	49	94	10	SM00164
Domain	RabGAP-TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.04e-13	53	94	10	PF00566
Domain	TBC_RABGAP	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.55e-13	55	94	10	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.55e-13	55	94	10	IPR000195
Domain	PP2A_PR55	PPP2R2A PPP2R2B PPP2R2C	4.92e-07	4	94	3	IPR000009
Domain	PP2A_PR55_CS	PPP2R2A PPP2R2B PPP2R2C	4.92e-07	4	94	3	IPR018067
Domain	PR55_2	PPP2R2A PPP2R2B PPP2R2C	4.92e-07	4	94	3	PS01025
Domain	PR55_1	PPP2R2A PPP2R2B PPP2R2C	4.92e-07	4	94	3	PS01024
Domain	Na+channel_ASC_CS	ASIC1 ASIC4 ASIC3	6.79e-06	8	94	3	IPR020903
Domain	ASC	ASIC1 ASIC4 ASIC3	1.01e-05	9	94	3	PF00858
Domain	ASC	ASIC1 ASIC4 ASIC3	1.01e-05	9	94	3	PS01206
Domain	Na+channel_ASC	ASIC1 ASIC4 ASIC3	1.01e-05	9	94	3	IPR001873
Domain	ENaC	ASIC1 ASIC3	5.18e-04	7	94	2	IPR004724
Domain	DHC_N1	DNAH10 DYNC1H1	6.88e-04	8	94	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH10 DYNC1H1	6.88e-04	8	94	2	IPR013594
Domain	Prot_inh_cystat_CS	CST2 CST4	8.82e-04	9	94	2	IPR018073
Domain	Cystatin	CST2 CST4	1.60e-03	12	94	2	IPR027214
Domain	CYSTATIN	CST2 CST4	1.60e-03	12	94	2	PS00287
Domain	WD40	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	1.97e-03	259	94	6	PF00400
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DYNC1H1	2.19e-03	14	94	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DYNC1H1	2.19e-03	14	94	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DYNC1H1	2.19e-03	14	94	2	IPR013602
Domain	DHC_N2	DNAH10 DYNC1H1	2.19e-03	14	94	2	PF08393
Domain	MT	DNAH10 DYNC1H1	2.19e-03	14	94	2	PF12777
Domain	AAA_8	DNAH10 DYNC1H1	2.19e-03	14	94	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DYNC1H1	2.19e-03	14	94	2	IPR011704
Domain	AAA_5	DNAH10 DYNC1H1	2.19e-03	14	94	2	PF07728
Domain	WD40	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	2.34e-03	268	94	6	SM00320
Domain	DHC_fam	DNAH10 DYNC1H1	2.52e-03	15	94	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DYNC1H1	2.52e-03	15	94	2	IPR004273
Domain	Dynein_heavy	DNAH10 DYNC1H1	2.52e-03	15	94	2	PF03028
Domain	WD40_repeat	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	2.52e-03	272	94	6	IPR001680
Domain	WD_REPEATS_1	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	2.81e-03	278	94	6	PS00678
Domain	WD_REPEATS_2	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	2.86e-03	279	94	6	PS50082
Domain	WD_REPEATS_REGION	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	2.86e-03	279	94	6	PS50294
Domain	CY	CST2 CST4	3.24e-03	17	94	2	SM00043
Domain	Cystatin_dom	CST2 CST4	3.64e-03	18	94	2	IPR000010
Domain	Cystatin	CST2 CST4	3.64e-03	18	94	2	PF00031
Domain	WD40_repeat_dom	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	3.89e-03	297	94	6	IPR017986
Domain	PRAME_family	PRAMEF19 PRAMEF18	4.05e-03	19	94	2	IPR026271
Domain	-	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	6.73e-03	333	94	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	6.92e-03	335	94	6	IPR015943
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L STARD3 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K	5.14e-11	99	70	10	M46448
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	PPP2R2A PPP2R2B PPP2R2C	1.07e-04	19	70	3	M47525
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ASIC1 TRPM1 ASIC4 ASIC3 UNC80	1.30e-04	99	70	5	MM14910
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	PPP2R2A PPP2R2B PPP2R2C	1.69e-04	22	70	3	M47919
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ASIC1 TRPM1 ASIC4 ASIC3 UNC80	1.79e-04	106	70	5	M27200
Pathway	PID_LIS1_PATHWAY	MAP1B PAFAH1B2 DYNC1H1	3.51e-04	28	70	3	M163
Pathway	WP_GLYCOGEN_METABOLISM	PPP2R2A PPP2R2B PPP2R2C	6.28e-04	34	70	3	MM15985
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.92e-29	11	96	11	16863688
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3B TBC1D3F	1.51e-09	74	96	7	16625196
Pubmed	Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.	PPP2R2A PPP2R2B PPP2R2C	2.04e-08	3	96	3	9514514
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	8.14e-08	4	96	3	12359748
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	8.14e-08	4	96	3	8406013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	2.03e-07	5	96	3	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	2.03e-07	5	96	3	8471161
Pubmed	Activation of protein phosphatase-2A1 by HIV-1 Vpr cell death causing peptide in intact CD(4+) T cells and in vitro.	PPP2R2A PPP2R2B PPP2R2C	2.03e-07	5	96	3	15578586
Pubmed	HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.	PPP2R2A PPP2R2B PPP2R2C	7.08e-07	7	96	3	25816751
Pubmed	IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.	CST2 CST4 IRF8	7.08e-07	7	96	3	21300820
Pubmed	The role of Vpr in HIV-1 pathogenesis.	PPP2R2A PPP2R2B PPP2R2C	1.13e-06	8	96	3	15638722
Pubmed	Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.	PPP2R2A PPP2R2B PPP2R2C	1.69e-06	9	96	3	19762425
Pubmed	Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.	PPP2R2A PPP2R2B PPP2R2C	5.71e-06	13	96	3	18971272
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	ASIC1 TRPM1 ASIC4 ASIC3	6.80e-06	44	96	4	19322198
Pubmed	Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.	PPP2R2A PPP2R2B PPP2R2C	7.26e-06	14	96	3	9013886
Pubmed	Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.	PPP2R2A PPP2R2B PPP2R2C	7.26e-06	14	96	3	9400615
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP2R2A PPP2R2B PPP2R2C	7.26e-06	14	96	3	16048649
Pubmed	C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.	ASIC1 ASIC3	7.54e-06	2	96	2	34380759
Pubmed	Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.	ASIC1 ASIC4	7.54e-06	2	96	2	18662336
Pubmed	Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.	PPP2R2A PPP2R2B	7.54e-06	2	96	2	24244166
Pubmed	ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury.	ASIC1 ASIC3	7.54e-06	2	96	2	20015700
Pubmed	ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+/RhoA pathway.	ASIC1 ASIC3	7.54e-06	2	96	2	28518134
Pubmed	ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand.	ASIC1 ASIC3	7.54e-06	2	96	2	26440887
Pubmed	Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.	ASIC1 ASIC3	7.54e-06	2	96	2	34918385
Pubmed	Extracellular acidosis modulates the endocytosis and maturation of macrophages.	ASIC1 ASIC3	7.54e-06	2	96	2	23435349
Pubmed	ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.	ASIC1 ASIC3	7.54e-06	2	96	2	33824228
Pubmed	ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.	ASIC1 ASIC3	7.54e-06	2	96	2	34569932
Pubmed	A role for acid-sensing ion channel 3, but not acid-sensing ion channel 2, in sensing dynamic mechanical stimuli.	ASIC1 ASIC3	7.54e-06	2	96	2	20693874
Pubmed	Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.	PPP2R2A PPP2R2B PPP2R2C	9.05e-06	15	96	3	16041367
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP2R2A PPP2R2B PPP2R2C	1.35e-05	17	96	3	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP2R2A PPP2R2B PPP2R2C	1.35e-05	17	96	3	21351466
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	XYLT2 ACTR1B RIF1 PPP2R2A ZNF609 AHI1 SAAL1 IFT88 SUB1 ESYT1 PAFAH1B2 CST4 DYNC1H1 STOML2	1.59e-05	1321	96	14	27173435
Pubmed	Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.	PPP2R2A PPP2R2B PPP2R2C	1.61e-05	18	96	3	23287597
Pubmed	Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.	PPP2R2A PPP2R2B PPP2R2C	1.91e-05	19	96	3	32582689
Pubmed	ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.	ASIC1 ASIC3	2.26e-05	3	96	2	19590043
Pubmed	Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells.	ASIC1 ASIC3	2.26e-05	3	96	2	30074209
Pubmed	Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function.	ASIC1 ASIC3	2.26e-05	3	96	2	15987792
Pubmed	Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.	PPP2R2A PPP2R2B	2.26e-05	3	96	2	16102737
Pubmed	Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder.	ASIC1 ASIC3	2.26e-05	3	96	2	26033064
Pubmed	Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones.	ASIC1 ASIC3	2.26e-05	3	96	2	14990679
Pubmed	Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.	PPP2R2A PPP2R2B	2.26e-05	3	96	2	1849734
Pubmed	Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.	ASIC1 ASIC3	2.26e-05	3	96	2	11854527
Pubmed	Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke.	ASIC1 ASIC3	2.26e-05	3	96	2	27402850
Pubmed	Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test.	ASIC1 ASIC3	2.26e-05	3	96	2	18801682
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	2.26e-05	3	96	2	21030649
Pubmed	Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.	ASIC1 ASIC3	2.26e-05	3	96	2	22157923
Pubmed	Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry.	CST2 CST4	2.26e-05	3	96	2	1898352
Pubmed	Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat.	CST2 CST4	2.26e-05	3	96	2	1471486
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF19 PRAMEF18	2.26e-05	3	96	2	21347312
Pubmed	Acid-induced pain and its modulation in humans.	ASIC1 ASIC3	2.26e-05	3	96	2	15574747
Pubmed	Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.	ASIC1 ASIC3	2.26e-05	3	96	2	15470133
Pubmed	Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells.	ASIC1 ASIC3	2.26e-05	3	96	2	28618956
Pubmed	Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target.	KIT CNTN2	2.26e-05	3	96	2	18304480
Pubmed	Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses.	ASIC1 ASIC3	2.26e-05	3	96	2	29474404
Pubmed	Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits.	ASIC1 ASIC3	2.26e-05	3	96	2	23109675
Pubmed	Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia.	ASIC1 ASIC3	2.26e-05	3	96	2	17177258
Pubmed	Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.	CST2 CST4	2.26e-05	3	96	2	1778989
Pubmed	Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.	ASIC1 ASIC3	2.26e-05	3	96	2	21321108
Pubmed	Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.	ASIC1 ASIC3	2.26e-05	3	96	2	10798398
Pubmed	Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase.	FBXW8 TBC1D3	2.26e-05	3	96	2	23029530
Pubmed	Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels.	ASIC1 ASIC3	2.26e-05	3	96	2	22960074
Pubmed	Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.	IRF8 KIT	4.51e-05	4	96	2	25398936
Pubmed	Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.	ASIC1 ASIC4	4.51e-05	4	96	2	25828470
Pubmed	MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance.	MAP1B CNTN2	4.51e-05	4	96	2	15186740
Pubmed	Stomatin modulates gating of acid-sensing ion channels.	ASIC1 ASIC3	4.51e-05	4	96	2	15471860
Pubmed	cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.	ASIC1 ASIC3	4.51e-05	4	96	2	12578970
Pubmed	Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.	KIT PTK7	4.51e-05	4	96	2	20709954
Pubmed	Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.	MAP1B DYNC1H1	4.51e-05	4	96	2	15762842
Pubmed	Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T.	CST2 CST4	4.51e-05	4	96	2	10713450
Pubmed	Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.	CST2 CST4	4.51e-05	4	96	2	13679380
Pubmed	BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.	BCL2L2 KIT	4.51e-05	4	96	2	11784036
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	AHI1 TTLL3 MAP1B IFT88 C1QTNF5 ASIC3	4.75e-05	233	96	6	32290105
Pubmed	HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.	PPP2R2A PPP2R2B PPP2R2C	5.06e-05	26	96	3	11531413
Pubmed	Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells.	CST2 CST4	7.50e-05	5	96	2	23671283
Pubmed	Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation.	CST2 CST4	7.50e-05	5	96	2	17592728
Pubmed	Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation.	CST2 CST4	7.50e-05	5	96	2	32616516
Pubmed	Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice.	CST2 CST4	7.50e-05	5	96	2	34440840
Pubmed	Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells.	CST2 CST4	7.50e-05	5	96	2	2241983
Pubmed	Strong conservation of the expression of cystatin C gene in choroid plexus.	CST2 CST4	7.50e-05	5	96	2	1636787
Pubmed	Gene deletion of cystatin C aggravates brain damage following focal ischemia but mitigates the neuronal injury after global ischemia in the mouse.	CST2 CST4	7.50e-05	5	96	2	15450354
Pubmed	Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.	CST2 CST4	7.50e-05	5	96	2	21443774
Pubmed	Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis.	CST2 CST4	7.50e-05	5	96	2	27079462
Pubmed	Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.	CST2 CST4	7.50e-05	5	96	2	10748866
Pubmed	Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice.	CST2 CST4	7.50e-05	5	96	2	15823274
Pubmed	Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.	CST2 CST4	7.50e-05	5	96	2	21085595
Pubmed	Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation.	CST2 CST4	7.50e-05	5	96	2	34914637
Pubmed	A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells.	CST2 CST4	7.50e-05	5	96	2	16595632
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF19 PRAMEF18	7.50e-05	5	96	2	16159394
Pubmed	Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.	ASIC1 ASIC3	7.50e-05	5	96	2	37054767
Pubmed	Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation.	CST2 CST4	7.50e-05	5	96	2	20489058
Pubmed	Neuroprotection mediated by cystatin C-loaded extracellular vesicles.	CST2 CST4	7.50e-05	5	96	2	31367000
Pubmed	Up-regulation of cystatin C expression in the murine hippocampus following perforant path transections.	CST2 CST4	7.50e-05	5	96	2	12044447
Pubmed	FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor.	CST2 CST4	7.50e-05	5	96	2	11144350
Pubmed	Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution.	CST2 CST4	7.50e-05	5	96	2	8761177
Pubmed	Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.	CST2 CST4	7.50e-05	5	96	2	24405769
Pubmed	Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide.	CST2 CST4	7.50e-05	5	96	2	14742906
Pubmed	Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease.	CST2 CST4	7.50e-05	5	96	2	19773092
Pubmed	Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.	PPP2R2A PPP2R2B	7.50e-05	5	96	2	17529992
Pubmed	Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis.	CST2 CST4	7.50e-05	5	96	2	33754041
Pubmed	Developmental regulation of synthesis and dimerization of the amyloidogenic protease inhibitor cystatin C in the hematopoietic system.	CST2 CST4	7.50e-05	5	96	2	24570004
Interaction	SERTAD4 interactions	PPP2R2A PPP2R2B PPP2R2C ZFP1	1.37e-06	19	90	4	int:SERTAD4
Interaction	EPHA1 interactions	PWP1 PPP2R2A SAAL1 GBF1 AARS2 DNAH10 ZNF471 DYNC1H1	1.03e-05	235	90	8	int:EPHA1
Interaction	TBC1D3 interactions	FBXW8 TBC1D3 TBC1D3F	1.38e-05	11	90	3	int:TBC1D3
Interaction	IER5 interactions	PPP2R2A PPP2R2B PPP2R2C	2.38e-05	13	90	3	int:IER5
Interaction	DISP1 interactions	FBXW8 CST2 CST4	3.03e-05	14	90	3	int:DISP1
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D STARD3 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	4.30e-16	149	96	12	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F	2.20e-06	99	96	5	17q12
Cytoband	5q13	MAP1B ADGRV1	9.73e-04	22	96	2	5q13
GeneFamily	Acid sensing ion channel subunits	ASIC1 ASIC4 ASIC3	2.65e-07	5	55	3	290
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2A PPP2R2B PPP2R2C	1.18e-05	15	55	3	696
GeneFamily	WD repeat domain containing	PWP1 PPP2R2A PPP2R2B PPP2R2C FBXW8 AHI1	1.40e-04	262	55	6	362
GeneFamily	Cystatins, type 2	CST2 CST4	1.06e-03	16	55	2	965
GeneFamily	PRAME family	PRAMEF19 PRAMEF18	2.40e-03	24	55	2	686
GeneFamily	Immunoglobulin like domain containing	ALPK3 KIT CNTN2 PTK7	2.81e-03	193	55	4	594
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	KIT PTK7	6.58e-03	40	55	2	321
Coexpression	GSE9037_WT_VS_IRAK4_KO_BMDM_UP	PWP1 RIF1 ZFP1 GPCPD1 RPRD2 NUBPL KLHL20	7.38e-06	200	93	7	M5812
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.91e-10	90	92	9	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	CLSTN3 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B ACOX3 TBC1D3K TBC1D3F	2.11e-09	213	92	11	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	CLSTN3 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B ACOX3 TBC1D3K TBC1D3F	2.11e-09	213	92	11	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	CLSTN3 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B ACOX3 TBC1D3K TBC1D3F	8.01e-09	242	92	11	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TTLL3 TBC1D3H TBC1D3L TBC1D3D CST2 CST4 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.38e-08	320	92	12	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	CLSTN3 TBC1D3 TTLL3 TBC1D3H TBC1D3L TBC1D3D YJU2B MRC2 CST2 CST4 ALPK3 BCL2L2 TBC1D3G KIT TBC1D3C TBC1D3B ACOX3 TBC1D3K TBC1D3F	4.11e-07	1153	92	19	PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.65e-06	281	92	9	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.65e-06	281	92	9	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	ACTR1B CLSTN3 AHI1 GBF1 TBC1D3 TTLL3 TBC1D3H TBC1D3L TBC1D3D YJU2B MRC2 PCDHGA3 TBC1D3G TBC1D3C TBC1D3B KLHL20 INO80B TBC1D3K TBC1D3F	1.39e-05	1466	92	19	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	MEIG1 TTLL3 MAP1B DNAH10 IFT88 SPAG17	3.33e-06	188	96	6	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	PBMC-Control-cDC_11\|Control / Compartment, Disease Groups and Clusters	MRC2 IRF8 TJP2 LDOC1 NUBPL KIT	4.11e-06	195	96	6	74d560ff0f47512441c305885c5c16272f711b8e
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2A PPP2R2B PPP2R2C	4.81e-06	12	84	3	DOID:1441 (implicated_via_orthology)
Disease	mental or behavioural disorder, substance abuse	PWP1 HFM1	1.19e-04	6	84	2	EFO_0000677, MONDO_0002491
Disease	cystatin-SN measurement	CST2 CST4	2.85e-04	9	84	2	EFO_0008106
Disease	Pathological accumulation of air in tissues	PPP2R2A PPP2R2C	5.19e-04	12	84	2	C0013990
Disease	idiopathic scoliosis (implicated_via_orthology)	DNAH10 PTK7	9.36e-04	16	84	2	DOID:0060250 (implicated_via_orthology)
Disease	cystatin-D measurement	CST2 CST4	1.06e-03	17	84	2	EFO_0008103
Disease	CCL4 measurement	TBC1D3 TBC1D3F	1.47e-03	20	84	2	EFO_0004751
Disease	Retinal Degeneration	AHI1 C1QTNF5	1.62e-03	21	84	2	C0035304
Disease	cerebrospinal fluid biomarker measurement	PAFAH1B2 CST4 CNTN2	2.63e-03	96	84	3	EFO_0006794

Protein segments in the cluster

Peptide	Gene	Start	Entry
EELNPQWGETYEVMV	ESYT1	376	Q9BSJ8
QWGETYEVMVHEVPG	ESYT1	381	Q9BSJ8
VWDLNMENRPIETYQ	PPP2R2B	306	Q00005
VWDLNMEARPIETYQ	PPP2R2C	306	Q9Y2T4
KPWIEAEYQGIVMEN	CLSTN3	26	Q9BQT9
EEEIPVLEYPMQQWR	ACOX3	341	O15254
DMQRVEPSLLQYADW	ACCS	121	Q96QU6
WDLNMENRPVETYQV	PPP2R2A	311	P63151
IVYVWNPETGEQVAM	AHI1	866	Q8N157
LPWMRPREHETQQYE	AMBN	86	Q9NP70
IRYPMEHGVVRDWND	ACTR1B	71	P42025
SDYEPVTRQWAIMQE	ADGRV1	2501	Q8WXG9
MEVAWLVYVLGQQPL	ALPK3	1	Q96L96
TERPDWQNVMLYVTA	SPECC1L	1096	Q69YQ0
EPLVGQVQEWMVAYL	BCL2L2	116	Q92843
VDPYMWEPQELGAVR	RBSN	86	Q9H1K0
IGVDSMYENWQVDRP	ITPRIP	191	Q8IWB1
ERVPGTVWNEIDDMQ	DAAM2	616	Q86T65
IPTHDSEVMREWYQE	MAP1B	2421	P46821
LTGEAEEWVVPYIEM	LDOC1	96	O95751
PMYEVQWKVVEEING	KIT	551	P10721
DQPWMVIEGIRQTEY	FSD1	216	Q9BTV5
QRMPVQYILGEWDFQ	HEMK1	106	Q9Y5R4
NGTMEIYQLPDWRLV	CPSF1	791	Q10570
DVVMLSPNEEGYWQI	FBXW8	321	Q8N3Y1
RQWLIEQIDSSMYPG	IRF8	11	Q02556
TVYPDSIQVLEIWNM	PRAMEF18	201	Q5VWM3
VDSWPEYQMVIIRPQ	GLYATL1	46	Q969I3
GWRVEFRPMEVQLTD	GCLC	421	P48506
YRGTVVWMVPENVDI	EHBP1L1	66	Q8N3D4
VWMVPENVDISVTLY	EHBP1L1	71	Q8N3D4
WDMEDVAPTGVRQVF	PHRF1	1436	Q9P1Y6
SQRDFQWVEQEPLMY	MRC2	1041	Q9UBG0
ESRIREWCEQQVPYM	KRT35	126	Q92764
IMLDIQQEEYLPIWR	ASIC4	226	Q96FT7
DIMLDVQQEEYLPVW	ASIC3	211	Q9UHC3
PIQFEQLAYLWMERQ	KCNT2	271	Q6UVM3
RWIQDEMELGYVQAP	PADI3	346	Q9ULW8
MEGVPLEQYRAWLDE	INO80B	111	Q9C086
ELPIMEQWDQPEIYG	HFM1	1231	A2PYH4
MFTQPEYRVSVWENV	PCDHGA3	241	Q9Y5H0
TYEAWIREQVMGSEP	PRSS36	281	Q5K4E3
IYELMENPSQAIEWL	IFT88	561	Q13099
IYDWMPEQPNIFQVE	GPCPD1	611	Q9NPB8
ERYDPQTNEWRMVAS	KLHL20	336	Q9Y2M5
MVRLEPEDQVWVQVG	C1QTNF5	196	Q9BXJ0
VDSWPEYQMVIIRPQ	GLYATL1B	46	A0A0U1RQE8
ELIVNWTPMSREYQN	CNTN2	726	Q02246
LNRMVIWHYPGEEVN	FLVCR2	331	Q9UPI3
MPDGIRREEFVQWVE	DYNC1H1	4296	Q14204
MPEEQTGLVRENYVW	GBF1	886	Q92538
QIYEVPWEDRMSLVN	CST2	121	P09228
EIYEVPWEDRMSLVN	CST4	121	P01036
RKYEQWMEVTEQVLP	DNAH10	621	Q8IVF4
IWEDRNVYPEEMIVA	RPRD2	126	Q5VT52
VRSENPEWLDVYMHI	SAAL1	256	Q96ER3
DVDFWIIPMIQGFVQ	INPP5F	226	Q9Y2H2
VVAMAVYTSERWDQP	NKG7	106	Q16617
GQPWMETYLQDILRA	COL6A6	1206	A6NMZ7
QVDWGQLDYLVVDMP	NUBPL	171	Q8TB37
QLMQQYEIWRELFSP	PAFAH1B2	51	P68402
VKQVSMVDRWPETGY	MEIG1	41	Q5JSS6
EQAPIQMGEEAVRWA	RIF1	171	Q5UIP0
TVYPDSIQVLEIWNM	PRAMEF19	201	Q5SWL8
VLIDIREYWMDPEGE	SUB1	81	P53999
VSPELWRQLEQYMGQ	SPATA31C1	451	P0DKV0
WDVYLVEGEQALMPI	TBC1D3L	286	B9A6J9
MAWELLTQVYGIPEE	AARS2	151	Q5JTZ9
ENVMIRYPVPSEWVK	STON2	726	Q8WXE9
YVIDEEPTWDIMVRQ	SPAG17	1246	Q6Q759
VYQEVILQPERMVLW	STARD3	296	Q14849
MLDIQQDEYLPVWGE	ASIC1	221	P78348
WDVYLVEGEQALMPI	TBC1D3B	286	A6NDS4
WDVYLVEGEQALMPI	TBC1D3H	286	P0C7X1
NYIAVGNMTPVIEVW	PWP1	206	Q13610
EWEQLDPSQRILYMD	ZFP1	21	Q6P2D0
LERGEEPWVYDQVDM	ZNF671	101	Q8TAW3
APGMEELIWEQYTVT	TJP2	21	Q9UDY2
YQVWPRMEEGAQQIF	UNC80	1656	Q8N2C7
WDVYLVEGEQALMPI	TBC1D3F	286	A6NER0
GRQAEMDPILWYRQE	ZNF609	1121	O15014
WDVYLVEGEQALMPI	TBC1D3E	286	A0A087X179
VPQQEAWVVERMGRF	STOML2	41	Q9UJZ1
AVVPQIDMEGDRNIW	TTLL3	266	Q9Y4R7
QGILIIRFEMPYNIW	YJU2B	41	P13994
NYVILVRMDGWPSLQ	TRPM1	846	Q7Z4N2
PEEREVWTYMKENGI	ZC3H7A	796	Q8IWR0
YVISLLEQGREPWEM	ZNF471	61	Q9BX82
YWRQLDDEVAQTPMP	RCHY1	196	Q96PM5
WDVYLVEGEQALMPI	TBC1D3D	286	A0A087WVF3
EWQHMGPVERTLYRD	ZNF782	21	Q6ZMW2
WDVYLVEGEQALMPI	TBC1D3G	286	Q6DHY5
WDVYLVEGEQALMPI	TBC1D3	286	Q8IZP1
PTVVWYRNQMLISED	PTK7	441	Q13308
WDVYLVEGEQALMPI	TBC1D3K	286	A0A087X1G2
AQGYDNVRVTPWRMV	XYLT2	281	Q9H1B5
WDVYLVEGEQALMPI	TBC1D3I	286	A0A087WXS9
WDVYLVEGEQALMPI	TBC1D3C	286	Q6IPX1