Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone binding

ANP32B APBB1 MCM2 CHD3 PTMS HINFP SUPT6H CHD5 ANP32E

1.50e-052651099GO:0042393
GeneOntologyMolecularFunctionstructural constituent of postsynaptic intermediate filament cytoskeleton

NEFH NEFL

8.83e-0531092GO:0099184
GeneOntologyCellularComponent90S preribosome

RRP7BP KRI1 NOP9 RRP7A

1.67e-05291124GO:0030686
GeneOntologyCellularComponentchromatin

FOXO3 BRPF3 NKX2-3 GON4L MCM2 CHD3 FOXD4L6 IRX1 AKAP8L BSX FOXD4L5 ZBTB46 FOXD4L4 BRD8 NEUROD2 FOXD4L1 FOXD4L3 CHD5 ANP32E TAF5 FOXD4

3.46e-05148011221GO:0000785
GeneOntologyCellularComponentCURI complex

RRP7BP RRP7A

8.51e-0531122GO:0032545
GeneOntologyCellularComponentUTP-C complex

RRP7BP RRP7A

8.51e-0531122GO:0034456
GeneOntologyCellularComponentkinesin II complex

KIF3A KIF3B

8.51e-0531122GO:0016939
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

GON4L CHD3 BRD8 CHD5 ANP32E

1.67e-04961125GO:0070603
GeneOntologyCellularComponentpostsynaptic intermediate filament cytoskeleton

NEFH NEFL

1.70e-0441122GO:0099160
GeneOntologyCellularComponentINO80-type complex

GON4L BRD8 ANP32E

4.45e-04281123GO:0097346
GeneOntologyCellularComponentATPase complex

GON4L CHD3 BRD8 CHD5 ANP32E

6.55e-041291125GO:1904949
GeneOntologyCellularComponenthistone deacetylase complex

CHD3 BRD8 CHD5 ANP32E

1.13e-03851124GO:0000118
DomainTF_fork_head_CS_2

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.02e-08461127IPR030456
DomainTF_fork_head_CS_1

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.19e-08471127IPR018122
DomainFH

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.61e-08491127SM00339
DomainFORK_HEAD_1

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.61e-08491127PS00657
DomainFORK_HEAD_2

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.61e-08491127PS00658
DomainFork_head_dom

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.61e-08491127IPR001766
DomainFORK_HEAD_3

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.61e-08491127PS50039
DomainForkhead

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.61e-08491127PF00250
DomainLRRcap

ANP32B PPP1R7 ANP32E

3.34e-05111123SM00446
DomainU2A'_phosphoprotein32A_C

ANP32B PPP1R7 ANP32E

3.34e-05111123IPR003603
DomainWHTH_DNA-bd_dom

FOXO3 FOXD4L6 HELQ FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.06e-042421128IPR011991
DomainCHDCT2

CHD3 CHD5

1.07e-0431122PF08074
DomainCHDNT

CHD3 CHD5

1.07e-0431122PF08073
DomainDUF1086

CHD3 CHD5

1.07e-0431122IPR009462
DomainDUF1087

CHD3 CHD5

1.07e-0431122IPR009463
DomainCHD_N

CHD3 CHD5

1.07e-0431122IPR012958
DomainCHD_C2

CHD3 CHD5

1.07e-0431122IPR012957
DomainDUF1087

CHD3 CHD5

1.07e-0431122PF06465
DomainDUF1086

CHD3 CHD5

1.07e-0431122PF06461
DomainDUF1087

CHD3 CHD5

1.07e-0431122SM01147
DomainDUF1086

CHD3 CHD5

1.07e-0431122SM01146
Domain-

FOXO3 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

3.44e-0421811271.10.10.10
DomainPHD

BRPF3 CHD3 KMT2D CHD5

1.07e-03751124PF00628
DomainTCEAL1

TCEAL3 TCEAL6

1.25e-0391122IPR010370
DomainZnf_PHD-finger

BRPF3 CHD3 KMT2D CHD5

1.30e-03791124IPR019787
DomainPHD

BRPF3 CHD3 KMT2D CHD5

2.02e-03891124SM00249
DomainZnf_PHD

BRPF3 CHD3 KMT2D CHD5

2.19e-03911124IPR001965
DomainZF_PHD_2

BRPF3 CHD3 KMT2D CHD5

2.57e-03951124PS50016
DomainZF_PHD_1

BRPF3 CHD3 KMT2D CHD5

2.66e-03961124PS01359
DomainTF_A-like/BEX

TCEAL3 TCEAL6

3.09e-03141122IPR021156
DomainCalpain_cysteine_protease

CAPN12 CAPN15

3.09e-03141122IPR022684
DomainBEX

TCEAL3 TCEAL6

3.09e-03141122PF04538
DomainCysPc

CAPN12 CAPN15

3.56e-03151122SM00230
DomainPeptidase_C2_calpain_cat

CAPN12 CAPN15

3.56e-03151122IPR001300
DomainPeptidase_C2

CAPN12 CAPN15

3.56e-03151122PF00648
DomainCALPAIN_CAT

CAPN12 CAPN15

3.56e-03151122PS50203
Domain-

CHD3 KMT2D CHD5

4.39e-035511231.10.30.10
DomainZF_C3H1

ZC3H18 ZFC3H1 ZC3H4

5.10e-03581123PS50103
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.09e-156114627092474
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

3.02e-14811468530406
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

9.05e-149114612412011
Pubmed

A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.83e-1213114616884697
Pubmed

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.83e-121311467957066
Pubmed

Six members of the mouse forkhead gene family are developmentally regulated.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

5.30e-121511467689224
Pubmed

Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

5.30e-1215114622045912
Pubmed

Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

8.46e-121611468861101
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

8.46e-1216114610208738
Pubmed

Functional equivalency between Otx2 and Otx1 in development of the rostral head.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

2.84e-111911469895322
Pubmed

Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

4.05e-1120114612812790
Pubmed

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

5.66e-112111469449667
Pubmed

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

7.76e-1122114617389379
Pubmed

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.39e-1024114611820816
Pubmed

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

1.39e-1024114629992973
Pubmed

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

2.37e-1026114615857913
Pubmed

Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

4.85e-1029114622972626
Pubmed

FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4

5.46e-105114412234674
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

NES ESS2 CWC27 ANP32B KRI1 MCM2 AKAP8L GTF3C1 ZC3H4 SUPT6H RRP12 MDC1 ANP32E RRP7A CAVIN1 CLSPN HSP90AB1

2.54e-089891141736424410
Pubmed

Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

3.55e-0811114412421752
Pubmed

Genome-scale study of transcription factor expression in the branching mouse lung.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

9.21e-0867114622711520
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ISLR2 BRPF3 USP11 TPRN CHD3 ZC3H18 GIGYF1 CRACR2B SKP1 AKAP8L BRD8 ZC3H4 CHD5 CAVIN1 TAF5 CLSPN PCM1

1.43e-0711161141731753913
Pubmed

Human transcription factor protein interaction networks.

ESS2 USP11 KRI1 GON4L CHD3 ZC3H18 GIGYF1 SKP1 AKAP8L ARID3B PTMS KMT2D BRD8 GTF3C1 CHD5 RRP12 MDC1 TAF5 PCM1

2.00e-0714291141935140242
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ABCF1 MCM2 CHD3 ZC3H18 AKAP8L KMT2D BRD8 GTF3C1 ZC3H4 RRP12 MDC1 DNMBP PCM1 HSP90AB1

2.61e-077741141415302935
Pubmed

Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein.

NES NEFH NEFL

3.41e-075114320353824
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

GON4L MCM2 CHD3 ZC3H18 SKP1 GTF3C1 RRP12 MDC1 ANP32E TAF5

7.43e-073941141027248496
Pubmed

Diverse fates of paralogs following segmental duplication of telomeric genes.

FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

7.65e-0722114415233989
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

FOXO3 FOXO3B ESS2 USP11 SKP1 ARID3B NOP9 KMT2D BRD8 FOXD4L1 GTF3C1 USO1 FOXD4 HSP90AB1

8.77e-078571141425609649
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

NES ABCF1 ANP32B USP11 MCM2 SKP1 AKAP8L PPP1R7 NEFL GTF3C1 USO1 ZC3H4 GYS1 RRP12 ANP32E HSP90AB1

1.12e-0611491141635446349
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ISLR2 BRPF3 PIEZO1 MCM2 TRANK1 ZC3H4 SUPT6H CHD5 SETBP1 MDC1 DNMBP

1.43e-065291141114621295
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ABCF1 GON4L CC2D1B CHD3 GIGYF1 AKAP8L NOP9 GTF3C1 ZC3H4 METTL16 CLSPN CLEC16A

1.60e-066501141238777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NES ABCF1 USP11 KRI1 ZC3H18 NEFL GTF3C1 SUPT6H RRP12 MDC1 RRP7A PCM1

1.68e-066531141222586326
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

ABCF1 LEMD3 USP11 MCM2 ZFC3H1 AKAP8L GTF3C1 SUPT6H RRP12 MDC1

2.00e-064401141034244565
Pubmed

Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system.

NES NEFH NEFL

2.84e-06911437720210
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ESS2 USP11 TPRN ZC3H18 SKP1 USO1 SUPT6H ANP32E CLSPN DNMBP PCM1

3.93e-065881141138580884
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

KRI1 MCM2 CHD3 ZC3H18 ZFC3H1 AKAP8L NOP9 GTF3C1 ZC3H4 RRP12 MDC1 RRP7A CAVIN1

4.36e-068471141335850772
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

ABCF1 KRI1 CHD3 ZC3H18 AKAP8L SUPT6H CHD5 RRP12 MDC1 RRP7A HSP90AB1

5.15e-066051141128977666
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

ABCF1 LEMD3 MCM2 SKP1 AKAP8L ARID3B RRP12 MDC1 CAVIN1

6.65e-06396114926687479
Pubmed

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.

TRH FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 ZC3H4 FOXD4

8.04e-06306114818973680
Pubmed

A census of human transcription factors: function, expression and evolution.

FOXO3 NKX2-3 GON4L IRX1 BSX HINFP FOXD4L4 KMT2D NEUROD2 FOXD4L1 FOXD4L3 SETBP1 FOXD4

9.18e-069081141319274049
Pubmed

Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1).

SYT2 RYR1 NEFH

9.58e-0613114330870432
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

KRI1 ZC3H18 ARID3B ZC3H4 RRP12 MDC1

9.80e-06148114632538781
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

ABCF1 PSD2 KRI1 MCM2 CHD3 NOP9 USO1 ZC3H4 SUPT6H GYS1 GNL1

1.05e-056531141133742100
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

GON4L BRD8 GTF3C1 SUPT6H MDC1 ANP32E

1.06e-05150114628242625
Pubmed

Diagnostic and prognostic value of CSF neurofilaments in a cohort of patients with motor neuron disease: A cross-sectional study.

NEFH NEFL

1.07e-052114233609080
Pubmed

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.

FOXO3 FOXO3B

1.07e-052114222588664
Pubmed

Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.

FOXO3 FOXO3B

1.07e-05211429852958
Pubmed

Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina.

KIF3A KIF3B

1.07e-052114210548469
Pubmed

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.

NEFH NEFL

1.07e-052114211487626
Pubmed

Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.

NEFH NEFL

1.07e-052114228500227
Pubmed

CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controls.

NEFH NEFL

1.07e-052114217290105
Pubmed

Neurofilament levels in patients with neurological diseases: A comparison of neurofilament light and heavy chain levels.

NEFH NEFL

1.07e-052114231199010
Pubmed

Torque generation of kinesin motors is governed by the stability of the neck domain.

KIF3A KIF3B

1.07e-052114222541555
Pubmed

Kinesin-2 KIF3AB exhibits novel ATPase characteristics.

KIF3A KIF3B

1.07e-052114225122755
Pubmed

Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.

ABCF1 GNL1

1.07e-052114224908204
Pubmed

Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.

NEFH NEFL

1.07e-052114227732645
Pubmed

The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds.

KIF3A KIF3B

1.07e-052114215345558
Pubmed

Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders.

NEFH NEFL

1.07e-052114219678766
Pubmed

KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.

KIF3A KIF3B

1.07e-05211427559760
Pubmed

Heterodimeric associations between neuronal intermediate filament proteins.

NEFH NEFL

1.07e-05211429388258
Pubmed

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.

ZC3H4 SUPT6H MDC1 CLSPN

1.22e-0543114434672947
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

NES ABCF1 ZC3H18 LMTK3 SKP1 AKAP8L NEFL NOP9 GTF3C1 ZC3H4 SUPT6H GYS1 RRP12 HSP90AB1

1.27e-0510821141438697112
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

ESS2 ANP32B USP11 SKP1 ARID3B GTF3C1 RRP12 CLSPN

1.68e-05339114830415952
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

ANP32B MCM2 ZFC3H1 SUPT6H RRP12 HSP90AB1

1.70e-05163114622113938
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NES LMTK3 SKP1 KIF3A PPP1R7 NEFH NEFL KIF3B ZC3H4 PPP1R3F TAF5 PCM1 HSP90AB1

1.71e-059631141328671696
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

FOXD4L6 SKP1 ZNF692 MEX3C FOXD4L5 FOXD4L4 NEUROD2 FOXD4L1 GTF3C1 FOXD4L3 FOXD4

2.25e-057091141122988430
Pubmed

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma.

ANP32B SUPT6H ANP32E

2.26e-0517114336352191
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

MCM2 CHD3 ZC3H18 ARID3B NEFL KMT2D GTF3C1 ZC3H4 SUPT6H

2.54e-05469114927634302
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

ANP32B USP11 MCM2 SMYD5 CHD3 ZC3H18 BRD8 GTF3C1 SUPT6H MDC1 ANP32E CAVIN1 METTL16

2.92e-0510141141332416067
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

ABCF1 LEMD3 CWC27 PIEZO1 GON4L ZFC3H1 SKP1 AKAP8L BRD8 SUPT6H RRP12 MDC1 PALM3 RRP7A TAF5 DNMBP

3.09e-0514971141631527615
Pubmed

Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits.

NEFH NEFL

3.19e-053114210461886
Pubmed

Construction of a Mex3c Gene-Deficient Mouse Model to Study C-FOS Expression in Hypothalamic Nuclei and Observe Morphological Differences in Embryonic Neural Tube Development.

NES MEX3C

3.19e-053114233191393
Pubmed

A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.

FOXO3 FOXO3B

3.19e-053114229925039
Pubmed

Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1.

NEFH NEFL

3.19e-053114211050249
Pubmed

Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins.

NEFH NEFL

3.19e-053114212641746
Pubmed

Sequence and structure of the mouse gene coding for the largest neurofilament subunit.

NEFH NEFL

3.19e-05311423220257
Pubmed

The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling.

KIF3A KIF3B

3.19e-053114218957512
Pubmed

Neurofilament homeostasis and motoneurone degeneration.

NEFH NEFL

3.19e-053114211135306
Pubmed

Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis.

NEFH NEFL

3.19e-053114216084104
Pubmed

Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits.

NEFH NEFL

3.19e-05311427790359
Pubmed

PKN associates and phosphorylates the head-rod domain of neurofilament protein.

NEFH NEFL

3.19e-05311428621664
Pubmed

Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.

KIF3A KIF3B

3.19e-053114226445448
Pubmed

Heterodimerization of Kinesin-2 KIF3AB Modulates Entry into the Processive Run.

KIF3A KIF3B

3.19e-053114227637334
Pubmed

Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein.

NEFH NEFL

3.19e-05311428110465
Pubmed

Neurofilaments and motor neuron disease.

NEFH NEFL

3.19e-053114217708953
Pubmed

Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.

KIF3A KIF3B

3.19e-053114211331403
Pubmed

Transgenic mice in the study of ALS: the role of neurofilaments.

NEFH NEFL

3.19e-05311429804382
Pubmed

Neurofilaments bind tubulin and modulate its polymerization.

NEFH NEFL

3.19e-053114219726663
Pubmed

Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B.

KIF3A KIF3B

3.19e-053114221909995
Pubmed

Negative regulatory regions are present upstream in the three mouse neurofilament genes.

NEFH NEFL

3.19e-05311421315909
Pubmed

Neurofilament Protein as a Potential Biomarker of Axonal Degeneration in Experimental Autoimmune Encephalomyelitis.

NEFH NEFL

3.19e-053114232189712
Pubmed

Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.

KIF3A KIF3B

3.19e-053114228761002
Pubmed

Methylation and expression of neurofilament genes in tissues and in cell lines of the mouse.

NEFH NEFL

3.19e-05311428510499
Pubmed

Axonal atrophy in aging is associated with a decline in neurofilament gene expression.

NEFH NEFL

3.19e-05311427563228
Pubmed

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.

CHD3 KMT2D

3.19e-053114226551667
Pubmed

Kinesin-2 and photoreceptor cell death: requirement of motor subunits.

KIF3A KIF3B

3.19e-053114216337628
Pubmed

MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.

NES PCM1

3.19e-053114226883496
Pubmed

NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth.

NEFH NEFL

3.19e-053114214662745
Pubmed

Cloning and developmental expression of the murine neurofilament gene family.

NEFH NEFL

3.19e-05311423103856
Pubmed

Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in transfected cells.

NEFH GYS1

3.19e-05311429231734
InteractionDHX40 interactions

CAPN12 ESS2 USP11 KRI1 ZC3H18 ZFC3H1 IFIT2 BRD8 ZC3H4 SUPT6H RRP12 CLSPN

1.30e-0824911112int:DHX40
InteractionZNF330 interactions

ESS2 LEMD3 CWC27 KRI1 CHD3 ZC3H18 ZFC3H1 ARID3B GTF3C1 SUPT6H RRP12 ANP32E RRP7A

1.08e-0644611113int:ZNF330
InteractionSNU13 interactions

USP11 MCM2 CHD3 ZC3H18 GTF3C1 TRIM55 RRP7A SRPK3 CAVIN1 METTL16

4.01e-0628511110int:SNU13
InteractionPPP2R2D interactions

CAPN12 MCM2 FOXD4L6 ZFC3H1 FOXD4L1 GYS1 CLEC16A FOXD4

4.20e-061681118int:PPP2R2D
InteractionCBX3 interactions

BRPF3 ESS2 LEMD3 CWC27 MCM2 CHD3 ARID3B PTMS GTF3C1 ZC3H4 CHD5 MDC1 ANP32E CLSPN

1.26e-0564611114int:CBX3
InteractionNOLC1 interactions

MCM2 CHD3 ZC3H18 SYT2 AKAP8L GTF3C1 RRP7A CAVIN1 FAM9A GNL1

1.27e-0532511110int:NOLC1
InteractionOBSL1 interactions

NES ABCF1 ECM2 MCM2 RSPH6A SKP1 NEFL GTF3C1 ZC3H4 SUPT6H RRP12 MDC1 CAVIN1 CLEC16A PCM1 HSP90AB1

3.43e-0590211116int:OBSL1
InteractionUSP28 interactions

USO1 ZC3H4 MDC1 TRIM55 CLSPN PCM1

3.82e-051131116int:USP28
InteractionPPP1CC interactions

USP11 TPRN APBB1 CHD3 ZC3H18 ZFC3H1 SKP1 PPP1R7 NEFL ZC3H4 SUPT6H GYS1 PPP1R3F CLEC16A

5.42e-0573811114int:PPP1CC
InteractionSMG7 interactions

ESS2 SYT2 KMT2D ZC3H4 CHD5 RRP12 CLSPN CLEC16A PCM1

6.85e-053191119int:SMG7
InteractionPOLR1G interactions

CWC27 KRI1 ZC3H18 ZFC3H1 SKP1 ARID3B GTF3C1 SUPT6H RRP12 ANP32E CLSPN

8.18e-0548911111int:POLR1G
InteractionH2BC3 interactions

GON4L MCM2 SMYD5 CHD3 ZC3H18 SKP1 KMT2D RRP12 MDC1 ANP32E

8.32e-0540611110int:H2BC3
Cytoband9q21.11

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3

9.40e-073011449q21.11
GeneFamilyIntermediate filaments Type IV

NES NEFH NEFL

1.41e-066763611
GeneFamilyANP32 acidic nuclear phosphoproteins

ANP32B ANP32E

1.73e-04576227
GeneFamilyPHD finger proteins

BRPF3 CHD3 KMT2D CHD5

5.60e-049076488
GeneFamilyTranscription elongation factor A like family

TCEAL3 TCEAL6

6.16e-0497621216
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

LMTK3 RYR1 PPP1R7 NEFL PPP1R3F

9.90e-04181765694
GeneFamilyPHD finger proteins|NuRD complex

CHD3 CHD5

1.12e-03127621305
GeneFamilyActins|Deafness associated genes

TPRN SLC26A5 BSND TMEM132E

1.31e-031137641152
GeneFamilyC2 domain containing|Calpains

CAPN12 CAPN15

1.77e-0315762975
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

PSD2 TRH SLC26A5 NKX2-3 FOXD4L6 CRACR2B FOXD4L5 FOXD4L4 NEUROD2 FOXD4L1 FOXD4L3 CHD5 FOXD4

2.22e-0660111413MM866
CoexpressionGSE3920_UNTREATED_VS_IFNA_TREATED_FIBROBLAST_DN

CWC27 KRI1 GON4L KMT2D ZFTA METTL16 RUNDC1 PCM1

2.75e-062001148M6687
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

FOXD4L6 SYT2 FOXD4L5 NEFH FOXD4L4 NEUROD2 FOXD4L1 FOXD4L3 TMEM132E FOXD4

3.76e-0635711410MM828
CoexpressionBENPORATH_ES_WITH_H3K27ME3

CACNA1D PSD2 TRH RTL5 SLC26A5 NKX2-3 IRX1 NEFH NEFL FOXD4L4 NEUROD2 FOXD4L1 FEZ1 FOXD4L3 TMEM132E CHD5 HS6ST3

6.56e-06111511417M10371
CoexpressionMORI_MATURE_B_LYMPHOCYTE_UP

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

7.10e-061061146MM595
CoexpressionGSE40274_CTRL_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

ABCF1 TPRN CC2D1B GIGYF1 AKAP8L CSGALNACT2 GTF3C1

7.75e-061641147M9113
CoexpressionBENPORATH_SUZ12_TARGETS

CACNA1D TCEAL3 TRH NKX2-3 IRX1 NEFH NEFL FOXD4L4 NEUROD2 FOXD4L1 FEZ1 FOXD4L3 TMEM132E TCEAL6 HS6ST3

4.32e-05103511415M9898
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3

FOXD4L6 FOXD4L5 NEFL FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

4.70e-052171147MM861
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NES FOXD4L5 ZBTB46 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

3.94e-07180113732d871738a24071b70084a7e80148a516110c78b
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NES FOXD4L5 ZBTB46 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

3.94e-071801137067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXD4

6.07e-061771136ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

CRACR2B NOP9 MACROD2 PALM3 METTL16 MAPKBP1

8.31e-061871136b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

CRACR2B NOP9 MACROD2 PALM3 METTL16 MAPKBP1

8.31e-06187113661c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ISLR2 TRH ANKS4B NLRP6 PPP1R3F

1.13e-051151135207d464c09caf9be361daa56c83cd7da5cf9ce47
Diseasedermoid cyst of ovary (implicated_via_orthology)

FOXO3 FOXO3B

1.14e-0521002DOID:5117 (implicated_via_orthology)
Diseaseprimary microcephaly (implicated_via_orthology)

RRP7BP RRP7A

3.40e-0531002DOID:0070297 (implicated_via_orthology)
Diseasehypothyroidism (biomarker_via_orthology)

TRH SLC26A5 NEFH NEFL

1.61e-04801004DOID:1459 (biomarker_via_orthology)
Diseasered blood cell density measurement

ANP32B PIEZO1 NKX2-3 IRX1 TFR2 ZBTB46 NEUROD2 ZC3H4 POLI PALM3 METTL16

1.97e-0488010011EFO_0007978
Diseaseneuromyelitis optica (is_marker_for)

NEFH NEFL

2.36e-0471002DOID:8869 (is_marker_for)
DiseaseMyopathies, Nemaline

NEFL SRPK3

3.14e-0481002C0206157
Diseasecandidiasis (implicated_via_orthology)

ANP32B SKP1 ANP32E

4.52e-04441003DOID:1508 (implicated_via_orthology)
DiseaseCreutzfeldt-Jakob disease (is_marker_for)

NEFH NEFL

5.03e-04101002DOID:11949 (is_marker_for)
Diseasecongenital hypothyroidism (implicated_via_orthology)

NEFH NEFL

1.01e-03141002DOID:0050328 (implicated_via_orthology)
Diseaserelapsing-remitting multiple sclerosis (is_marker_for)

NEFH NEFL

1.16e-03151002DOID:2378 (is_marker_for)
Diseasemean corpuscular hemoglobin concentration

ANP32B PIEZO1 NKX2-3 GON4L GIGYF1 TFR2 NLRP6 NEUROD2 CLSPN CAPN15 HSP90AB1

1.31e-03110510011EFO_0004528
Diseaseallergic disease, age at onset

KIF3A POLI CLEC16A

1.83e-03711003EFO_0004847, MONDO_0005271
Diseaseage at first sexual intercourse measurement

CACNA1D SLC52A1 ZBTB46 KIF3B MACROD2 HS6ST3

1.97e-033831006EFO_0009749
DiseaseDeaf Mutism

CACNA1D SLC26A5

2.08e-03201002C4082305
DiseaseDeafness, Acquired

CACNA1D SLC26A5

2.08e-03201002C0751068
DiseaseHearing Loss, Extreme

CACNA1D SLC26A5

2.08e-03201002C0086395
DiseaseComplete Hearing Loss

CACNA1D SLC26A5

2.08e-03201002C0581883
DiseasePrelingual Deafness

CACNA1D SLC26A5

2.08e-03201002C0011052
DiseaseBilateral Deafness

CACNA1D SLC26A5

2.08e-03201002C3665473
DiseaseNonsyndromic Deafness

TPRN SLC26A5 TMEM132E

2.66e-03811003C3711374
DiseaseDeafness

CACNA1D SLC26A5

3.24e-03251002C0011053

Protein segments in the cluster

PeptideGeneStartEntry
PEEEDGGLEDEDGDD

ARID3B

91

Q8IVW6
GPEGGEGKEEKEEEE

PABPN1L

41

A6NDY0
EGEGEEEEEEGGESK

ABCF1

231

Q8NE71
EALPEKEGEELGEGE

CAVIN1

176

Q6NZI2
KEGEELGEGERPEED

CAVIN1

181

Q6NZI2
EKGDAPDLVDDGEDE

CWC27

251

Q6UX04
GIQWEPKDDDDEEEE

CHD5

391

Q8TDI0
PKDDDDEEEEGGCEE

CHD5

396

Q8TDI0
SQIKDAPGEDEEEDG

BRD8

621

Q9H0E9
GPEELEAEAGAEELE

CCDC96

116

Q2M329
SKEEGDLLEPGDEEA

ANKRD13C

16

Q8N6S4
LTEPEDEVDIGDEGE

BSX

211

Q3C1V8
EGLKEGDGEEEEEEE

BRPF3

411

Q9ULD4
GEEEIGPDEDEEEPG

DNMBP

231

Q6XZF7
PDEGEEKAAGEAEEE

APBB1

146

O00213
DEDEEEEEGGKGEKR

ANP32B

226

Q92688
VEEGEEEEEEEEGGL

ANP32E

236

Q9BTT0
EDEEGKEDGREEGKE

AKAP8L

331

Q9ULX6
DSPEEEKEQEEAEGG

AKAP8L

551

Q9ULX6
GEEPEDVQGEGLDED

ISLR2

666

Q6UXK2
GAEEEEVEEPLGVEK

PALM3

476

A6NDB9
EGEGEDGEERDPETE

LEMD3

221

Q9Y2U8
GPLEEEEDGEELIGD

MCM2

61

P49736
KEEQEEEEGAAEPRG

CAPN15

131

O75808
EKPKIEDVGSDEEDD

HSP90AB1

246

P08238
AEEEEEEEEDGKDGP

NOP9

161

Q86U38
EEEEDGKDGPTETLE

NOP9

166

Q86U38
EEEEDTAEKPGKEED

MDC1

1841

Q14676
EEEEPSEGLEEEGPE

GIGYF1

336

O75420
DGEDGKIDVLGEEED

FOXD4L4

21

Q8WXT5
DGEDGKIDVLGEEED

FOXD4L3

21

Q6VB84
PGPAEEDGEDEDEDE

LMTK3

1271

Q96Q04
PAGEIDDEDKDKDET

PCM1

1731

Q15154
QPGEKEEEDDNEEEG

MDM1

456

Q8TC05
PSEKEEGEEGEEECG

NES

1346

P48681
EPTEDERSEEKGGVE

METTL16

461

Q86W50
EEKPQFEEEEGLEDD

KRI1

411

Q8N9T8
VGPAGDEEEEEEEEL

GNL1

546

P36915
DRDADEEGEGDEETP

GNL1

571

P36915
PEEEEEVLEEEDGGE

FEZ1

181

Q99689
ADEEGEENGLKDDLP

ANKS4B

316

Q8N8V4
DDDEEGEVGEDGEKR

KIF3A

391

Q9Y496
DGEDGKIDVLGEEED

FOXD4

21

Q12950
EDEEPGDPREGEEEE

HS6ST3

91

Q8IZP7
GDPREGEEEEEEDEP

HS6ST3

96

Q8IZP7
EEKEEEEEEGEEEGG

FAM9A

231

Q8IZU1
EEGKEEEGGEEEEAE

NEFH

481

P12036
LEDGEAGEEEEKEPL

ESS2

131

Q96DF8
MIPEEEDDEDDEDGG

FOXO3B

141

A0A2Z4LIS9
EPDEEDDEDEEGPWG

CAPN12

391

Q6ZSI9
EDDEQEDEEGPLGEK

CSGALNACT2

196

Q8N6G5
SDTGGEEPEKEEEDL

BSND

281

Q8WZ55
GSEEEDEDFDERPEG

CHD3

1366

Q12873
GEEEEEGKEEKEPAA

GAS2L2

836

Q8NHY3
KPGADEAQEEEGELE

CRACR2B

6

Q8N4Y2
GGEKNGPEEEEEEDF

GON4L

1451

Q3T8J9
EVLGVDEETEPLDGD

CC2D1B

111

Q5T0F9
EGEEDEEDEEDPVRG

ECM2

281

O94769
PAEGDEEEEEEEGGM

MAPKBP1

1036

O60336
GEEEGEGEKLVEEAL

IFIT2

226

P09913
DGEDGKIDVLGEEED

FOXD4L1

21

Q9NU39
AAELVPGDEGKEEEE

HELQ

31

Q8TDG4
GPLEEDGERYDEDEE

GYS1

666

P13807
GSGEEEEEEEEDDPL

HINFP

46

Q9BQA5
VEPEEEGGGDDDEED

POLI

6

Q9UNA4
GEERGEEDPEEEHEL

PPP1R7

51

Q15435
EEAAEGEKEEGLEEG

RYR1

1911

P21817
SDGGEEDEEDEGEKL

NKX2-3

56

Q8TAU0
EDIDPENEEEGGEEG

CACNA1D

446

Q01668
GAKGLEDTEEPEEEE

NLRP6

596

P59044
DQEEKEGEKAPGEDT

MACROD2

376

A1Z1Q3
MIPEEEDDEDDEDGG

FOXO3

56

O43524
AVGPKAKDEEEEEEE

RUNDC1

16

Q96C34
KDEEDEDEDGGQKPE

RTL5

421

Q5HYW3
EEDLGEEEEKADEGP

RSPH6A

566

Q9H0K4
EGEGEGEEEKEPENL

SYT2

126

Q8N9I0
LDDEDEEGENEEGKP

TAF5

386

Q15542
EDEDDESEDPGKDLD

USO1

946

O60763
VPAGEEDEEEEEDLG

TMEM132E

1031

Q6IEE7
DAEVDGEDATKPEEE

SLC26A5

596

P58743
GEDATKPEEEDGEVK

SLC26A5

601

P58743
EGDPEKAEDDEEIDL

IRX1

211

P78414
DGEDGKIDVLGEEED

FOXD4L5

21

Q5VV16
DGEDGKIDVLGEEED

FOXD4L6

21

Q3SYB3
PEAAELELEEDEEEG

MEX3C

101

Q5U5Q3
EEEEEEEEEPAQGKG

RRP12

1056

Q5JTH9
EEEEPAQGKGDSIEE

RRP12

1061

Q5JTH9
GLLGSDDEEQEDPKD

SRPK3

46

Q9UPE1
VGEEEDEEKGPTEDA

CLEC16A

396

Q2KHT3
PTDKEEEDEEEEFGD

CLSPN

986

Q9HAW4
EEEAKAKEEEGVPDE

RRP7A

186

Q9Y3A4
EEAKAKEEEGVPDEE

RRP7BP

11

Q9NSQ0
EGDEAEDEEQRGPEL

SUPT6H

501

Q7KZ85
EEDLEGKEEGREDDP

RINL

236

Q6ZS11
EEEDGEEIEPEHEGR

SPRYD3

381

Q8NCJ5
EDEEEEEGGEGEKEG

TRIM55

331

Q9BYV6
GSPGAEEEEKEEEEA

SLC52A1

236

Q9NWF4
EEEEGEEGEEEGDDK

KIF3B

396

O15066
GGDEDDDEEDTDKLL

PSD2

256

Q9BQI7
DEEEEEEDDEGPALK

PTMS

66

P20962
EVEPDDEGKSDEEEK

TCEAL6

21

Q6IPX3
DEGKSDEEEKPDAEG

TCEAL6

26

Q6IPX3
LEDLGMDDEGDDDPV

SKP1

31

P63208
LIKDTEDPDDEGEGE

PPP1R3F

566

Q6ZSY5
EVEPDDEGKSDEEEK

TCEAL3

21

Q969E4
DEGKSDEEEKPDVEG

TCEAL3

26

Q969E4
PDDREDGELEEGELE

ZC3H4

51

Q9UPT8
DGELEEGELEDDGAE

ZC3H4

56

Q9UPT8
EEEEEEGSGSEEKPF

TPRN

616

Q4KMQ1
PGKREEEEEEGVEEE

TRH

86

P20396
GEAEAPEEEEEKEKE

TTC16

571

Q8NEE8
EEEGEEEKEAPTGRE

PIEZO1

1896

Q92508
KESPGGEEEEEEEDE

TRANK1

1081

O15050
LGKDGSLEDDEDEED

GTF3C1

1606

Q12789
EDEEDDLDEGVGGKR

GTF3C1

1616

Q12789
EEEGEPEDAELGDEM

SMYD5

401

Q6GMV2
EPEEEDELGSGRDVD

SETBP1

56

Q9Y6X0
KGHLEEEEEDGEEGA

TFR2

31

Q9UP52
EKEDDEEDKDDVPGP

USP11

656

P51784
PKEEGELEDGEISDD

ZFC3H1

16

O60293
EELGEDDEGLAPEDA

ZBTB46

546

Q86UZ6
PPGEEEGEEEEDNDE

ZNF692

186

Q9BU19
GPAEEEEELEEGEGE

ZFTA

386

C9JLR9
DEGGGDEEEEPEEEE

ZFTA

511

C9JLR9
DDDDLEEGEVKDPSD

ZC3H18

201

Q86VM9
GPDDKKDGDLDTDEL

KMT2D

1636

O14686
AEVKEEGELGGEEEE

NEUROD2

71

Q15784
PSEGEAEEEEKDKEE

NEFL

471

P07196
ESEEAKEEEEGGEGE

NEFL

501

P07196
KEEEEGGEGEEGEET

NEFL

506

P07196