Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in AV node cell action potential	CACNA1C CACNA1G	6.56e-05	3	94	2	GO:0086056
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1C NIPAL4 TRPC4AP SLC12A9 MCU KCNJ12 CACNA1G KCNJ18 ASIC3 PKD1L3	6.71e-05	465	94	10	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1C TRPC4AP MCU KCNJ12 CACNA1G KCNJ18 ASIC3 PKD1L3	2.16e-04	343	94	8	GO:0005261
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1G	2.17e-04	5	94	2	GO:0086007
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	2.17e-04	5	94	2	GO:0140444
GeneOntologyMolecularFunction	calcium channel activity	CACNA1C TRPC4AP MCU CACNA1G PKD1L3	3.61e-04	129	94	5	GO:0005262
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1C NIPAL4 TRPC4AP SLC12A9 MCU KCNJ12 CACNA1G KCNJ18 ASIC3 PKD1L3	7.33e-04	627	94	10	GO:0022890
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1C TRPC4AP MCU CACNA1G PKD1L3	7.40e-04	151	94	5	GO:0015085
GeneOntologyBiologicalProcess	cell-cell signaling involved in lung development	FGF10 EXT1	2.01e-05	2	93	2	GO:0060495
GeneOntologyBiologicalProcess	regulation of anatomical structure size	SPTBN5 CACNA1C KAT2B SEMA7A SLC12A9 MYO5B CACNA1G EXT1 ACTN2 SERPINF2 KLK1 VASP	2.14e-05	618	93	12	GO:0090066
GeneOntologyCellularComponent	filopodium	FAT1 SYNE2 ENAH ACTN2 LCP1 VASP	1.96e-05	123	94	6	GO:0030175
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1C OLFM3 MCU KCNJ12 LRRTM4 CACNA1G OLFM2 KCNJ18 PKD1L3	5.17e-05	378	94	9	GO:0034702
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1C ABCA2 OLFM3 MCU KCNJ12 LRRTM4 CACNA1G OLFM2 KCNJ18 PKD1L3	1.21e-04	523	94	10	GO:1902495
GeneOntologyCellularComponent	transporter complex	CACNA1C ABCA2 OLFM3 MCU KCNJ12 LRRTM4 CACNA1G OLFM2 KCNJ18 PKD1L3	1.83e-04	550	94	10	GO:1990351
GeneOntologyCellularComponent	actin-based cell projection	FAT1 SYNE2 ENAH ACTN2 LCP1 VASP NEDD4	2.61e-04	278	94	7	GO:0098858
GeneOntologyCellularComponent	AMPA glutamate receptor complex	OLFM3 LRRTM4 OLFM2	3.27e-04	30	94	3	GO:0032281
GeneOntologyCellularComponent	Derlin-1 retrotranslocation complex	SEL1L HM13	5.50e-04	8	94	2	GO:0036513
GeneOntologyCellularComponent	apical cortex	SPTBN5 MYO5B	8.79e-04	10	94	2	GO:0045179
GeneOntologyCellularComponent	membrane protein complex	SEL1L CACNA1C ABCA2 OLFM3 VPS39 SYNE1 MCU KCNJ12 SYNE2 LRRTM4 CACNA1G IRS1 OLFM2 KCNJ18 HM13 PKD1L3	9.93e-04	1498	94	16	GO:0098796
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE1 SYNE2	1.07e-03	11	94	2	GO:0034992
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE1 SYNE2	1.07e-03	11	94	2	GO:0034993
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE1 SYNE2	1.07e-03	11	94	2	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE1 SYNE2	1.07e-03	11	94	2	GO:0106094
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	OLFM3 LRRTM4 OLFM2	1.09e-03	45	94	3	GO:0008328
GeneOntologyCellularComponent	myofibril	CACNA1C KAT2B SYNE1 SYNE2 ACTN2 ALPG	1.46e-03	273	94	6	GO:0030016
GeneOntologyCellularComponent	neurotransmitter receptor complex	OLFM3 LRRTM4 OLFM2	1.48e-03	50	94	3	GO:0098878
GeneOntologyCellularComponent	contractile muscle fiber	CACNA1C KAT2B SYNE1 SYNE2 ACTN2 ALPG	1.99e-03	290	94	6	GO:0043292
Domain	Actinin_actin-bd_CS	SPTBN5 SYNE1 SYNE2 ACTN2 LCP1	8.61e-08	23	93	5	IPR001589
Domain	ACTININ_2	SPTBN5 SYNE1 SYNE2 ACTN2 LCP1	8.61e-08	23	93	5	PS00020
Domain	ACTININ_1	SPTBN5 SYNE1 SYNE2 ACTN2 LCP1	8.61e-08	23	93	5	PS00019
Domain	CH	SPTBN5 CFAP47 SYNE1 SYNE2 ACTN2 LCP1	1.31e-06	70	93	6	PF00307
Domain	-	SPTBN5 CFAP47 SYNE1 SYNE2 ACTN2 LCP1	1.43e-06	71	93	6	1.10.418.10
Domain	CH	SPTBN5 CFAP47 SYNE1 SYNE2 ACTN2 LCP1	1.69e-06	73	93	6	PS50021
Domain	CH-domain	SPTBN5 CFAP47 SYNE1 SYNE2 ACTN2 LCP1	1.98e-06	75	93	6	IPR001715
Domain	Spectrin	SPTBN5 SYNE1 SYNE2 ACTN2	4.74e-06	23	93	4	PF00435
Domain	Spectrin_repeat	SPTBN5 SYNE1 SYNE2 ACTN2	1.24e-05	29	93	4	IPR002017
Domain	CH	SPTBN5 SYNE1 SYNE2 ACTN2 LCP1	1.79e-05	65	93	5	SM00033
Domain	Spectrin/alpha-actinin	SPTBN5 SYNE1 SYNE2 ACTN2	1.86e-05	32	93	4	IPR018159
Domain	SPEC	SPTBN5 SYNE1 SYNE2 ACTN2	1.86e-05	32	93	4	SM00150
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	2.45e-05	2	93	2	IPR003272
Domain	K_chnl_inward-rec_Kir_N	KCNJ12 KCNJ18	7.33e-05	3	93	2	IPR013673
Domain	VASP_tetra	ENAH VASP	7.33e-05	3	93	2	IPR014885
Domain	IRK_N	KCNJ12 KCNJ18	7.33e-05	3	93	2	PF08466
Domain	VASP_tetra	ENAH VASP	7.33e-05	3	93	2	PF08776
Domain	Cse1	IPO8 IPO7	7.33e-05	3	93	2	IPR013713
Domain	Noelin-1	OLFM3 OLFM2	7.33e-05	3	93	2	PF12308
Domain	Noelin_dom	OLFM3 OLFM2	7.33e-05	3	93	2	IPR022082
Domain	Cse1	IPO8 IPO7	7.33e-05	3	93	2	PF08506
Domain	KASH	SYNE1 SYNE2	1.46e-04	4	93	2	PF10541
Domain	KASH	SYNE1 SYNE2	1.46e-04	4	93	2	IPR012315
Domain	KASH	SYNE1 SYNE2	1.46e-04	4	93	2	PS51049
Domain	KASH	SYNE1 SYNE2	1.46e-04	4	93	2	SM01249
Domain	Sel1	SEL1L DELE1	6.74e-04	8	93	2	PF08238
Domain	SEL1	SEL1L DELE1	6.74e-04	8	93	2	SM00671
Domain	Sel1-like	SEL1L DELE1	8.63e-04	9	93	2	IPR006597
Domain	VDCCAlpha1	CACNA1C CACNA1G	1.08e-03	10	93	2	IPR002077
Domain	WH1	ENAH VASP	1.31e-03	11	93	2	SM00461
Domain	WH1/EVH1_dom	ENAH VASP	1.31e-03	11	93	2	IPR000697
Domain	WH1	ENAH VASP	1.31e-03	11	93	2	PF00568
Domain	TF_fork_head_CS_2	FOXK2 FOXI3 FOXF2	1.55e-03	46	93	3	IPR030456
Domain	TF_fork_head_CS_1	FOXK2 FOXI3 FOXF2	1.65e-03	47	93	3	IPR018122
Domain	OLF	OLFM3 OLFM2	1.85e-03	13	93	2	PS51132
Domain	WH1	ENAH VASP	1.85e-03	13	93	2	PS50229
Domain	Olfac-like_dom	OLFM3 OLFM2	1.85e-03	13	93	2	IPR003112
Domain	OLF	OLFM3 OLFM2	1.85e-03	13	93	2	SM00284
Domain	OLF	OLFM3 OLFM2	1.85e-03	13	93	2	PF02191
Domain	FH	FOXK2 FOXI3 FOXF2	1.87e-03	49	93	3	SM00339
Domain	FORK_HEAD_1	FOXK2 FOXI3 FOXF2	1.87e-03	49	93	3	PS00657
Domain	FORK_HEAD_2	FOXK2 FOXI3 FOXF2	1.87e-03	49	93	3	PS00658
Domain	Fork_head_dom	FOXK2 FOXI3 FOXF2	1.87e-03	49	93	3	IPR001766
Domain	FORK_HEAD_3	FOXK2 FOXI3 FOXF2	1.87e-03	49	93	3	PS50039
Domain	Forkhead	FOXK2 FOXI3 FOXF2	1.87e-03	49	93	3	PF00250
Domain	IMPORTIN_B_NT	IPO8 IPO7	2.15e-03	14	93	2	PS50166
Domain	Ldl_recept_b	LRP2 LRP1B	2.15e-03	14	93	2	PF00058
Domain	LDLRB	LRP2 LRP1B	2.15e-03	14	93	2	PS51120
Domain	IBN_N	IPO8 IPO7	2.47e-03	15	93	2	PF03810
Domain	LY	LRP2 LRP1B	2.47e-03	15	93	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP1B	2.47e-03	15	93	2	IPR000033
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ12 KCNJ18	2.81e-03	16	93	2	IPR013518
Domain	IBN_N	IPO8 IPO7	2.81e-03	16	93	2	SM00913
Domain	IRK	KCNJ12 KCNJ18	2.81e-03	16	93	2	PF01007
Domain	-	KCNJ12 KCNJ18	2.81e-03	16	93	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ12 KCNJ18	2.81e-03	16	93	2	IPR016449
Domain	Importin-beta_N	IPO8 IPO7	3.18e-03	17	93	2	IPR001494
Domain	EGF_CA	FAT1 FAT2 LRP2 LRP1B	3.23e-03	122	93	4	SM00179
Domain	EGF-like_Ca-bd_dom	FAT1 FAT2 LRP2 LRP1B	3.43e-03	124	93	4	IPR001881
Domain	EGF	FAT1 FAT2 LRP2 LRP1B	3.63e-03	126	93	4	PF00008
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	SEL1L TRPC4AP IPO8 IPO7 VPS39 SYNE1 SYNE2 ZFR CACNA1G C1orf167 PRPF8 PLRG1	1.17e-06	754	96	12	35906200
Pubmed	Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.	FAT1 ENAH VASP	1.69e-06	9	96	3	15148305
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	URB1 CUX2 VPS39 SYNE1 SYNE2 ZBTB40 CACNA1G	3.16e-06	225	96	7	12168954
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	7.54e-06	2	96	2	22768332
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	7.54e-06	2	96	2	11792814
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	7.54e-06	2	96	2	24931616
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	7.54e-06	2	96	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	7.54e-06	2	96	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	7.54e-06	2	96	2	24586179
Pubmed	Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.	SYNE2 ENAH	7.54e-06	2	96	2	36959177
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	7.54e-06	2	96	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	7.54e-06	2	96	2	31578382
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	7.54e-06	2	96	2	15705530
Pubmed	Distribution, cellular localization, and postnatal development of VASP and Mena expression in mouse tissues.	ENAH VASP	7.54e-06	2	96	2	11810195
Pubmed	Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility.	ENAH VASP	7.54e-06	2	96	2	12940993
Pubmed	Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.	IRS1 FOXF2	7.54e-06	2	96	2	20009030
Pubmed	The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.	MTMR4 NEDD4	7.54e-06	2	96	2	19125695
Pubmed	Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels.	CACNA1C NEDD4	7.54e-06	2	96	2	21220429
Pubmed	Association of CACNA1C and SYNE1 in offspring of patients with psychiatric disorders.	CACNA1C SYNE1	7.54e-06	2	96	2	27620326
Pubmed	Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy.	ENAH VASP	7.54e-06	2	96	2	12933343
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1C CACNA1G ACTN2	1.35e-05	17	96	3	27725084
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	USP31 CACTIN URB1 IPO8 DNAJC10 IPO7 N4BP2 SYNE1 SYNE2 CHD1 VARS2 HM13 PRPF8 PLRG1 VPS13B	1.37e-05	1487	96	15	33957083
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SEL1L TRPC4AP MTMR4 FOXK2 IPO8 DNAJC10 IPO7 PKP3 CHD1 LCP1 PRPF8 FN3K	1.57e-05	974	96	12	28675297
Pubmed	Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.	KCNJ12 KCNJ18	2.26e-05	3	96	2	17640933
Pubmed	An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis.	ENAH VASP	2.26e-05	3	96	2	21423205
Pubmed	A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons.	ENAH VASP	2.26e-05	3	96	2	28735747
Pubmed	VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis.	ENAH VASP	2.26e-05	3	96	2	19435808
Pubmed	Cell autonomous defects in cortical development revealed by two-color chimera analysis.	ENAH VASP	2.26e-05	3	96	2	19386231
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	2.26e-05	3	96	2	10878022
Pubmed	Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.	OLFM3 OLFM2	2.26e-05	3	96	2	21228389
Pubmed	Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.	FAT1 FAT2	2.26e-05	3	96	2	15744052
Pubmed	Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.	CACNA1C CACNA1G	2.26e-05	3	96	2	22133878
Pubmed	Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.	ENAH VASP	2.26e-05	3	96	2	23937664
Pubmed	Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.	ENAH VASP	2.26e-05	3	96	2	10801818
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	2.26e-05	3	96	2	16079285
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	2.26e-05	3	96	2	12408964
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ12 KCNJ18	2.26e-05	3	96	2	8083233
Pubmed	Preferential utilization of Imp7/8 in nuclear import of Smads.	IPO8 IPO7	2.26e-05	3	96	2	18519565
Pubmed	The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes.	KCNJ12 KCNJ18	2.26e-05	3	96	2	11410627
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	2.26e-05	3	96	2	17462627
Pubmed	Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.	KCNJ12 KCNJ18	2.26e-05	3	96	2	10904001
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1C CACNA1G	2.26e-05	3	96	2	31919478
Pubmed	Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.	CYP11A1 NEDD4	2.26e-05	3	96	2	32450490
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1C CACNA1G	2.26e-05	3	96	2	37739992
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	2.26e-05	3	96	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	2.26e-05	3	96	2	25516977
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	OLFM3 LRRTM4 OLFM2	3.95e-05	24	96	3	22632720
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	SEL1L FAT1 DNAJC10 SEMA7A ARSK VWA5A MCU ENAH EXT1 IRS1 VARS2 PRPF8 CTSB NEDD4	4.43e-05	1451	96	14	30550785
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	CACNA1C SYNE1 ACTN2	4.49e-05	25	96	3	38877142
Pubmed	Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11.	KCNJ12 KCNJ18	4.51e-05	4	96	2	8921409
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	4.51e-05	4	96	2	16648470
Pubmed	Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.	ENAH VASP	4.51e-05	4	96	2	15469845
Pubmed	Ena/VASP is required for endothelial barrier function in vivo.	ENAH VASP	4.51e-05	4	96	2	17998398
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2	4.51e-05	4	96	2	23071752
Pubmed	Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination.	ENAH VASP	4.51e-05	4	96	2	21398369
Pubmed	Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.	TXNRD1 LRP2	4.51e-05	4	96	2	24434121
Pubmed	Mena binds α5 integrin directly and modulates α5β1 function.	ENAH VASP	4.51e-05	4	96	2	22908313
Pubmed	The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins.	FAT1 ENAH	4.51e-05	4	96	2	16979624
Pubmed	Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.	CACNA1C ACTN2	4.51e-05	4	96	2	17110593
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2	4.51e-05	4	96	2	20108321
Pubmed	Whole-genome association study of bipolar disorder.	CACNA1C MYO5B	4.51e-05	4	96	2	18317468
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ12 KCNJ18	4.51e-05	4	96	2	20798526
Pubmed	A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.	KCNJ12 KCNJ18	4.51e-05	4	96	2	32990585
Pubmed	Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system.	ENAH VASP	4.51e-05	4	96	2	15371503
Pubmed	Characterization of early EDEM1 protein maturation events and their functional implications.	SEL1L DNAJC10	4.51e-05	4	96	2	21632540
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	4.51e-05	4	96	2	19596800
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1C CACNA1G	4.51e-05	4	96	2	21788606
Pubmed	The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.	SEL1L DNAJC10	4.51e-05	4	96	2	23363602
Pubmed	Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.	SERPINF2 KLK1	4.51e-05	4	96	2	9368023
Pubmed	Mena is required for neurulation and commissure formation.	ENAH VASP	4.51e-05	4	96	2	10069337
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2	4.51e-05	4	96	2	28716842
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	FAT1 FOXK2 FOXI3 PRPF8	7.34e-05	80	96	4	34591877
Pubmed	PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.	ENAH VASP	7.50e-05	5	96	2	15642358
Pubmed	Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.	ENAH VASP	7.50e-05	5	96	2	16631741
Pubmed	A novel class of RanGTP binding proteins.	IPO8 IPO7	7.50e-05	5	96	2	9214382
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ12 KCNJ18	7.50e-05	5	96	2	16177047
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2	7.50e-05	5	96	2	18396275
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2	7.50e-05	5	96	2	22632968
Pubmed	A luminal flavoprotein in endoplasmic reticulum-associated degradation.	SEL1L DNAJC10	7.50e-05	5	96	2	19706418
Pubmed	The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members.	ENAH VASP	7.50e-05	5	96	2	16376568
Pubmed	Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.	N4BP2 NEDD4	7.50e-05	5	96	2	11717310
Pubmed	A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion.	ENAH VASP	7.50e-05	5	96	2	27091449
Pubmed	Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.	ENAH VASP	7.50e-05	5	96	2	16336193
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	URB1 IPO7 SYNE2 WDR46 ZFR CHD1 LCP1 PRPF8 MVP	8.33e-05	653	96	9	22586326
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	KCNJ12 CACNA1G KCNJ18	8.66e-05	31	96	3	17473172
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	SEL1L TRHDE ABCA2 DNAJC10 ARSK	9.48e-05	164	96	5	32409323
Pubmed	Lem2 is essential for cardiac development by maintaining nuclear integrity.	SYNE1 SYNE2 ACTN2	9.54e-05	32	96	3	37067297
Pubmed	A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors.	OLFM3 OLFM2	1.12e-04	6	96	2	37591201
Pubmed	Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue.	ASIC3 PKD1L3	1.12e-04	6	96	2	19812697
Pubmed	Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.	KCNJ12 KCNJ18	1.12e-04	6	96	2	9529344
Pubmed	The inward rectifier potassium channel family.	KCNJ12 KCNJ18	1.12e-04	6	96	2	7580148
Pubmed	Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.	ENAH VASP	1.12e-04	6	96	2	24076656
Pubmed	Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1.	ENAH VASP	1.12e-04	6	96	2	16319076
Pubmed	TES is a novel focal adhesion protein with a role in cell spreading.	ENAH VASP	1.12e-04	6	96	2	12571287
Pubmed	The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.	ENAH VASP	1.12e-04	6	96	2	26702829
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	1.12e-04	6	96	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	1.12e-04	6	96	2	18827015
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FAT1 CUX2 SLC12A9 MYO5B LRP2 LCP1 PKD1L3 KLK1 MVP VASP STRIP1	1.15e-04	1016	96	11	19056867
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SEL1L IPO8 DNAJC10 IPO7 MCU CHD1 IRS1 HM13 PRPF8 PLRG1 STRIP1 TBC1D24	1.19e-04	1203	96	12	29180619
Pubmed	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	SEL1L CACNA1G IRS1 C1orf167	1.21e-04	91	96	4	20416077
GeneFamily	ENAH/VASPs	ENAH VASP	3.13e-05	3	59	2	946
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	6.26e-05	4	59	2	1252
GeneFamily	Low density lipoprotein receptors	LRP2 LRP1B	7.98e-04	13	59	2	634
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ12 KCNJ18	1.22e-03	16	59	2	276
GeneFamily	Cadherin related	FAT1 FAT2	1.38e-03	17	59	2	24
GeneFamily	Armadillo repeat containing\|Importins	IPO8 IPO7	1.55e-03	18	59	2	596
GeneFamily	NLR family	NLRC3 NLRP13	2.99e-03	25	59	2	666
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1G	3.24e-03	26	59	2	253
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NIPAL4 ABCA2 SEMA7A ACTN2 MVP FN3K CNDP1	2.22e-07	195	96	7	1e28617ca55e5f318a228357737b968dfac8cca0
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRHDE CACNA1C SYNE1 LRRTM4 CACNA1G IRS1 FOXF2	2.63e-07	200	96	7	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-8\|TCGA-Kidney / Sample_Type by Project: Shred V9	TXNRD1 MCU GNPTG CTSB MVP FN3K	2.51e-06	179	96	6	8c6a84602b079bd357c66244371eb23dd9384918
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRHDE CACNA1C LRRTM4 ENAH FGF10 ACTN2	2.59e-06	180	96	6	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRHDE CACNA1C LRRTM4 ENAH FGF10 ACTN2	2.59e-06	180	96	6	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	tumor_Lung-Myeloid_cells-CD207+CD1a+_LCs\|tumor_Lung / Location, Cell class and cell subclass	SEMA7A CACNA1G OLFM2 LCP1 SERPINF2 VASP	2.77e-06	182	96	6	243779ba1009097f8fafa1a691e296ec3aeefc04
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE FAT1 OTOGL LRP2 SPAG17 LRP1B	2.95e-06	184	96	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE FAT1 OTOGL LRP2 SPAG17 LRP1B	2.95e-06	184	96	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE FAT1 OTOGL LRP2 SPAG17 LRP1B	2.95e-06	184	96	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCP1 SERPINF2 KLK1 NLRC3 CNDP1	1.97e-05	152	96	5	bfc7ef4ee26165d18ac4f475a9519e8d52453ba2
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE LRRTM4 LRP2 FGF10 LRP1B	2.52e-05	160	96	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE LRRTM4 LRP2 FGF10 LRP1B	2.52e-05	160	96	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Cbln4_(Neuron.Slc17a7.Cbln4)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SPTBN5 FAT2 PRDM12 TTC22	2.59e-05	79	96	4	d24301b6694f64e8bb1b5f0673f653d25d45d3eb
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Cbln4_(Neuron.Slc17a7.Cbln4)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SPTBN5 FAT2 PRDM12 TTC22	2.59e-05	79	96	4	397f3a1f5fa67dd0b2ed53ebcad74dedf0498fce
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO5B SYNE2 LRP2 TTC22 KLK1	3.09e-05	167	96	5	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO5B SYNE2 LRP2 TTC22 KLK1	3.09e-05	167	96	5	351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE CUX2 OLFM3 OTOGL OLFM2	3.36e-05	170	96	5	3174ea9cf93892a8b41de10fd4ff6f06bb41502d
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	FAT2 MAB21L3 CMIP IRS1 TTC22	3.46e-05	171	96	5	adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SEMA7A CYP11A1 SYNE1 PKP3 SYNE2	3.46e-05	171	96	5	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	USP31 FAT2 CROT MAB21L3 CMIP	3.86e-05	175	96	5	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	CACNA1G ACTN2 LCP1 SERPINF2 VASP	4.41e-05	180	96	5	289f8c4b53ffd164fee1f459a9315c0deb5f76d0
ToppCell	severe-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SEMA7A CYP11A1 SYNE1 SYNE2 NLRC3	4.41e-05	180	96	5	ac03812b1409435c55d323a7516deeac82bd3509
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRHDE CACNA1C LRRTM4 FGF10 ACTN2	4.53e-05	181	96	5	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C OTOGL LRRTM4 IRS1 OLFM2	4.53e-05	181	96	5	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCA2 ARSK SYNE1 SYNE2 FOXI3	4.53e-05	181	96	5	12ff56fa2949c8d53360cdf2cacfd326e65b54aa
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C NIPAL4 FAT1 ENAH IRS1	5.03e-05	185	96	5	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CMIP OTOGL OGFR SPAG17 LRP1B	5.16e-05	186	96	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRHDE MYO5B SYNE2 LRP2 LRP1B	5.29e-05	187	96	5	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C FAT1 ENAH IRS1 FOXF2	5.29e-05	187	96	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE CUX2 OLFM3 OTOGL LRRTM4	5.43e-05	188	96	5	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	CACNA1C FAT1 ENAH IRS1 FOXF2	5.56e-05	189	96	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	CACNA1C FAT1 ENAH IRS1 FOXF2	5.70e-05	190	96	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 CMIP SYNE2 ZFR NEDD4	5.85e-05	191	96	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C FAT1 SYNE1 IRS1 FOXF2	5.85e-05	191	96	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 CMIP SYNE2 ZFR NEDD4	5.85e-05	191	96	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 CMIP SYNE2 ZFR NEDD4	5.85e-05	191	96	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	CACNA1G ACTN2 OLFM2 SERPINF2 VASP	5.99e-05	192	96	5	f18da8db573e584c8b90df0814afcf020360108e
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	CMIP SYNE2 LRP2 EXT1 VPS13B	5.99e-05	192	96	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRHDE CACNA1C FGF10 EXT1 ACTN2	6.14e-05	193	96	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C FAT1 LRRTM4 ENAH IRS1	6.30e-05	194	96	5	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 MYO5B MCU SYNE2 LRP2	6.30e-05	194	96	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 SYNE1 SYNE2 ENAH SPAG17	6.45e-05	195	96	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 SYNE1 SYNE2 ENAH SPAG17	6.45e-05	195	96	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	FAT1 FAT2 CROT SYNE2 IRS1	6.61e-05	196	96	5	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 SYNE1 SYNE2 ENAH SPAG17	6.61e-05	196	96	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 SYNE1 SYNE2 ENAH SPAG17	6.61e-05	196	96	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells\|LPS_only / Treatment groups by lineage, cell group, cell type	CUX2 SEMA7A LCP1 PKD1L3 CTSB	6.77e-05	197	96	5	59ddd8ff7dddf3747b988374e1a4d80959db803e
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	EFCAB5 VPS39 SYNE1 SYNE2 LCP1	6.93e-05	198	96	5	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	NIPAL4 MAB21L3 DNAJC10 SYNE2 IRS1	7.10e-05	199	96	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	Bronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT1 LRRTM4 OLFM2 FOXF2	7.27e-05	200	96	5	12326cc6f0af24bacba9493dc79e7c7347db2f41
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	TRHDE SYNE1 ENAH FGF10 ACTN2	7.27e-05	200	96	5	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Mast_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA7A CD22 VWA5A ASIC3 LCP1	7.27e-05	200	96	5	c3511607692e05f44538a376253673dd18f77908
ToppCell	Bronchial-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT1 LRRTM4 OLFM2 FOXF2	7.27e-05	200	96	5	362706445edb33b313684efe50b1f44f5f816e67
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	TRHDE SYNE1 ENAH FGF10 ACTN2	7.27e-05	200	96	5	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Mast_cell-Mast_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA7A CD22 VWA5A ASIC3 LCP1	7.27e-05	200	96	5	1c58860932ed47263a5a537a64f0343201463c21
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C LRRTM4 FGF10 CACNA1G FOXF2	7.27e-05	200	96	5	fb53be20392a8309a7393774c774a1b1aec6e676
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	6.26e-05	4	96	2	cv:CN293514
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.04e-04	5	96	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	1.04e-04	5	96	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	1.56e-04	6	96	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	1.56e-04	6	96	2	C0410189
Disease	progressive familial intrahepatic cholestasis (is_implicated_in)	SEMA7A MYO5B	2.18e-04	7	96	2	DOID:0070221 (is_implicated_in)
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	2.18e-04	7	96	2	C0751337
Disease	memory performance	TXNRD1 FOXK2 N4BP2 SYNE2 LRRTM4 ACTN2 PRPF8	3.86e-04	409	96	7	EFO_0004874
Disease	fibrinogen measurement, tissue plasminogen activator measurement	HECTD4 PKD1L3 PLRG1	4.29e-04	45	96	3	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	HECTD4 PKD1L3 PLRG1	4.29e-04	45	96	3	EFO_0004623, EFO_0004792
Disease	tauopathy (implicated_via_orthology)	ENAH VASP	4.63e-04	10	96	2	DOID:680 (implicated_via_orthology)
Disease	pneumonia, COVID-19	FAT1 RSAD1 LRP1B VPS13B	5.16e-04	113	96	4	EFO_0003106, MONDO_0100096
Disease	reticulocyte count	KAT2B FAT1 FOXK2 NUDT14 KCNJ12 SYNE2 HECTD4 ZBTB40 IRS1 LCP1 PRPF8	5.90e-04	1045	96	11	EFO_0007986
Disease	sleep quality	CACNA1C PRSS38 LRP1B PIGZ	6.08e-04	118	96	4	EFO_0005272
Disease	reticulocyte measurement	KAT2B FAT1 FOXK2 NUDT14 KCNJ12 SYNE2 HECTD4 ZBTB40 IRS1 LCP1 PRPF8	6.28e-04	1053	96	11	EFO_0010700
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	6.77e-04	12	96	2	DOID:11726 (implicated_via_orthology)
Disease	alcohol consumption measurement, alcohol drinking	CUX2 HECTD4	6.77e-04	12	96	2	EFO_0004329, EFO_0007878
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	HECTD4 PKD1L3 PLRG1	8.16e-04	56	96	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	Prostatic Neoplasms	DNAJC10 PKP3 LRP2 FGF10 CHD1 IRS1 CTSB LRP1B	9.13e-04	616	96	8	C0033578
Disease	Malignant neoplasm of prostate	DNAJC10 PKP3 LRP2 FGF10 CHD1 IRS1 CTSB LRP1B	9.13e-04	616	96	8	C0376358
Disease	3-hydroxypropylmercapturic acid measurement	TRHDE USP31 FOXK2 EXT1 LCP1 LRP1B	1.04e-03	352	96	6	EFO_0007014
Disease	susceptibility to hepatitis B infection measurement	CACNA1C MYO5B ENAH	1.20e-03	64	96	3	EFO_0008405
Disease	retinal vasculature measurement	TXNRD1 CACNA1C KAT2B SLC12A9 SERPINF2 FOXF2 STRIP1	1.52e-03	517	96	7	EFO_0010554
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	MYO5B LCP1	1.73e-03	19	96	2	EFO_0004612, EFO_0008589
Disease	facial attractiveness measurement	EXT1 LRP1B	1.73e-03	19	96	2	EFO_0009892
Disease	cystatin C measurement	CUX2 SEMA7A HECTD4 LRP2 HM13 TBC1D24	2.04e-03	402	96	6	EFO_0004617
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	CMIP SYNE2 LCP1 CTSB	2.15e-03	166	96	4	EFO_0004530, EFO_0004611
Disease	nephrosis (biomarker_via_orthology)	CYP11A1 LRP2	2.32e-03	22	96	2	DOID:2527 (biomarker_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	TRHDE CACNA1C N4BP2 ENAH EXT1 PKD1L3 LRP1B	2.52e-03	566	96	7	EFO_0007660, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
IHKYGNAARNDLWNT	TRHDE	556	Q9UKU6
GQNYSNVIANLRWHQ	ARSK	496	Q6UWY0
AQQFQGTARWYQHTR	C1orf167	891	Q5SNV9
APYRNVNIQNFHTSW	ACTN2	166	P35609
KRNTTWQAGHNFYNV	CTSB	36	P07858
LLNAIHFQGFWRNKF	SERPINF2	231	P08697
LQAANSYLRDQWFHS	CMIP	141	Q8IY22
NLKTNTVINWFHNYR	CUX2	1206	O14529
LRDYQLNGLNWLAHS	CHD1	481	O14646
TWNNGHQVLYNVTLF	OLFM2	431	O95897
YLRGVNNARQPWHNA	KIAA0895L	286	Q68EN5
WHAVALEVNGNYARL	FAT1	3911	Q14517
FYQRSKAGWQNSIRH	FOXI3	181	A8MTJ6
LQVHYWASFAQQRGI	KIAA0100	1331	Q14667
NNLYWTNDGHRKTIN	LRP1B	611	Q9NZR2
VHQRIASWQNLGAVY	MCU	51	Q8NE86
QARSSYLANEILWGH	KCNJ12	311	Q14500
CISDNYQLWLGRHNL	KLK1	66	P06870
YQLWLGRHNLFDDEN	KLK1	71	P06870
HYFRGINNLQQPWNS	KIAA0895	336	Q8NCT3
FAGLNQLIWLYLDHN	LRRTM4	81	Q86VH4
GRIFYINHNIKRTQW	NEDD4	906	P46934
HLQWNFIQAGAAQAL	NLRC3	896	Q7RTR2
FLNRINYWHLEAPSQ	KAT2B	251	Q92831
LTLHYRQNGAQKSWD	NUDT14	21	O95848
GWQNSIRHNLSLNRY	FOXK2	301	Q01167
NWVSNYNALRAAAGI	CANT1	261	Q8WVQ1
LRWANYHLENAGCNK	LCP1	271	P13796
WRTGYNFQRVHAAVQ	PLRG1	441	O43660
NWMEYLHGFNLSLQA	FAT2	321	Q9NYQ8
NRNPVWYQALTHGLN	IPO7	971	O95373
HWIANNLFGLAFSLN	HM13	181	Q8TCT9
GNWYLANNRKHCIVD	LRP2	2681	P98164
DKVLGYFWNRQHSQR	ASIC3	466	Q9UHC3
LQARGALYTAHAQAW	PGGHG	221	Q32M88
QELLVWYGNSHNTFL	PRDM12	196	Q9H4Q4
GLVNLRVAGNHTQWY	PRSS38	116	A1L453
NGRAVHYNGSSLLQW	HECTD4	2041	Q9Y4D8
WYQALLQLHNRAKGH	IRS1	106	P35568
RSLTQSHIQYFQWGR	POM121L12	56	Q8N7R1
TADHARLQLQLAYNW	MVP	531	Q14764
RLQLQLAYNWHFEVN	MVP	536	Q14764
NYHWQLSFLRAEQVL	MAB21L3	231	Q8N8X9
WALLRAGNKNFHNFL	MTMR4	531	Q9NYA4
NLVQEWLAKHQGARY	ALPG	251	P10696
VQYHGNIFFWNQSRN	EFCAB5	1081	A4FU69
QHEQTFRWNAYSGIL	GNPTG	91	Q9UJJ9
HPNAYLRNGWNLLDF	CACNA1C	186	Q13936
NGRNHLIFNLYSGTW	EXT1	186	Q16394
RWVRHKYNFDNLGQA	CACNA1G	1461	O43497
GRLQQHLRWLQQYVA	ABCA2	506	Q9BZC7
TQNFYWELRQKGSVH	CYP11A1	281	P05108
YQFWQFHKGNLQAGQ	MS4A14	651	Q96JA4
FNRVHTGFEWNKYNQ	CACTIN	646	Q8WUQ7
SFNWQHNGRQMYVAL	FGF10	166	O15520
TFHQWRDARQVYGLN	ENAH	76	Q8N8S7
RWLLFFHFGKNENSN	DNAJC10	366	Q8IXB1
GNFNNLRFWYNLEIH	CFAP47	2531	Q6ZTR5
YNARDRALYAWNNGH	OLFM3	446	Q96PB7
RALYAWNNGHQVLFN	OLFM3	451	Q96PB7
DWNNQSLPYHSQKLR	CD22	631	P20273
LWLAANNGDSQSRYH	DELE1	376	Q14154
QLERGSITLWHNLNY	CROT	121	Q9UKG9
NQWFYGHTSCLNLRE	OTOGL	1826	Q3ZCN5
AFNYLNQGVVHSITW	IPO8	326	O15397
YQKRFQNLNWRSHNN	OGFR	196	Q9NZT2
YQGWKNSVRHNLSLN	FOXF2	141	Q12947
NFARNGALSTHNWTY	RSAD1	276	Q9HA92
KAGLLYRNHQLVNWS	VARS2	266	Q5ST30
QARSSYLANEILWGH	KCNJ18	311	B7U540
LNNFHNLLRFWQQHY	TRPC4AP	726	Q8TEL6
WNSASQLREQYILHQ	SYNE1	5556	Q8NF91
QSLLQLWKAYSNAHG	SYNE2	5381	Q8WXH0
LHWNRAASQGYTVAR	SEL1L	616	Q9UBV2
QLFNYLNHWNHFGRE	FN3K	281	Q9H479
SAKNSNRFYLHQAIW	PKD1L3	1301	Q7Z443
QKVRHRLNDDWAYGN	STRIP1	741	Q5VSL9
FTGQLLNHIASLYNW	URB1	266	O60287
LNHIASLYNWNGITD	URB1	271	O60287
QLNNRWASFHGNLLR	SPTBN5	2341	Q9NRC6
WASFHGNLLRYQQQL	SPTBN5	2346	Q9NRC6
WNIALHSNVGFRNYL	SPAG17	836	Q6Q759
GEHSQNEKINRWNYI	CNDP1	476	Q96KN2
LANLWQYNKLHRDFR	PKP3	771	Q9Y446
THQRHDGKLWNLNNY	PRPF8	1456	Q6P2Q9
KQLARQGYWAQSHAL	TBC1D24	36	Q9ULP9
QNHIGSLNWGYRVAL	TXNRD1	256	Q16881
WGYVSQALLFHQVRK	SLC12A9	501	Q9BXP2
QEGSYFREAQHWQLL	SEMA7A	616	O75326
LVQLIYHQNANGSWD	VWA5A	681	O00534
TFWANNHGRNYTVLL	PPP1R3F	271	Q6ZSY5
FGVLHAQALQAAWQR	PIGZ	326	Q86VD9
LAVAQNRWLHIYDNQ	WDR46	251	O15213
ATFHSWQERIRQNYG	NIPAL4	41	Q0D2K0
LRHAKWFQARANGLQ	ZFR	906	Q96KR1
LLLQAIYQSWSHLGN	VPS13B	806	Q7Z7G8
DSNNHLYWNALGVVA	TTC37	821	Q6PGP7
YRGNSQHDAQEFLLW	USP31	221	Q70CQ4
NAWANLAHVYGRLGQ	TTC22	101	Q5TAA0
CNKAYQQLSGLWYHN	ZBTB40	1011	Q9NUA8
GSNIIYVASNHFVWR	VPS39	291	Q96JC1
KYNQATPNFHQWRDA	VASP	71	P50552
HWANGVLFQQRFSYV	NLRP13	251	Q86W25
RNALAKHIYAQLFGW	MYO5B	401	Q9ULV0
VKYLGEAHEWNQNRA	N4BP2	486	Q86UW6