Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	virion binding	CD209 CRP	5.35e-04	10	70	2	GO:0046790
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1C NCF1B	5.35e-04	10	70	2	GO:0016176
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1C NCF1B	7.82e-04	12	70	2	GO:0016175
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM3A KDM4E	1.07e-03	14	70	2	GO:0032454
GeneOntologyMolecularFunction	glucosidase activity	LCTL AGL	1.24e-03	15	70	2	GO:0015926
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP6V0E1 ABCC8 ATP6V0E2	1.35e-03	62	70	3	GO:0019829
GeneOntologyMolecularFunction	low-density lipoprotein particle binding	CDH13 CRP	1.79e-03	18	70	2	GO:0030169
GeneOntologyMolecularFunction	growth factor binding	FGFBP2 NTRK2 NRP2 COL1A2	2.20e-03	156	70	4	GO:0019838
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	NCF1C NCF1B	2.21e-03	20	70	2	GO:0050664
GeneOntologyMolecularFunction	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	ATP6V0E1 ATP6V0E2	3.18e-03	24	70	2	GO:0044769
GeneOntologyMolecularFunction	proton-transporting ATPase activity, rotational mechanism	ATP6V0E1 ATP6V0E2	3.18e-03	24	70	2	GO:0046961
GeneOntologyMolecularFunction	ATPase-coupled ion transmembrane transporter activity	ATP6V0E1 ATP6V0E2	3.18e-03	24	70	2	GO:0042625
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM3A KDM4E	4.32e-03	28	70	2	GO:0141052
GeneOntologyBiologicalProcess	response to yeast	NCF1C NCF1B CD209	3.07e-05	18	71	3	GO:0001878
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHA10 PCDHA8 PCDHA3 PCDHA2 SDK1 CDH13	4.50e-05	187	71	6	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHA10 PCDHA8 PCDHA3 PCDHA2 SDK1 CD209 CDH13	1.00e-04	313	71	7	GO:0098742
GeneOntologyBiologicalProcess	formaldehyde metabolic process	KDM3A ALDH3A2	1.16e-04	5	71	2	GO:0046292
GeneOntologyBiologicalProcess	neutrophil-mediated killing of gram-positive bacterium	NCF1C NCF1B	1.16e-04	5	71	2	GO:0070946
GeneOntologyCellularComponent	multivesicular body lumen	PGA4 PGA5	2.43e-04	7	72	2	GO:0097486
GeneOntologyCellularComponent	IgM immunoglobulin complex, circulating	IGKV3D-15 IGKV3-15	3.23e-04	8	72	2	GO:0071754
GeneOntologyCellularComponent	pentameric IgM immunoglobulin complex	IGKV3D-15 IGKV3-15	3.23e-04	8	72	2	GO:0071756
GeneOntologyCellularComponent	monomeric IgA immunoglobulin complex	IGKV3D-15 IGKV3-15	4.15e-04	9	72	2	GO:0071748
GeneOntologyCellularComponent	polymeric IgA immunoglobulin complex	IGKV3D-15 IGKV3-15	5.17e-04	10	72	2	GO:0071749
GeneOntologyCellularComponent	IgA immunoglobulin complex, circulating	IGKV3D-15 IGKV3-15	5.17e-04	10	72	2	GO:0071746
GeneOntologyCellularComponent	secretory IgA immunoglobulin complex	IGKV3D-15 IGKV3-15	5.17e-04	10	72	2	GO:0071751
GeneOntologyCellularComponent	late endosome lumen	PGA4 PGA5	6.31e-04	11	72	2	GO:0031906
GeneOntologyCellularComponent	cation-transporting ATPase complex	ATP6V0E1 ABCC8 ATP6V0E2	6.44e-04	49	72	3	GO:0090533
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0E1 ATP6V0E2	7.55e-04	12	72	2	GO:0033179
GeneOntologyCellularComponent	ATPase dependent transmembrane transport complex	ATP6V0E1 ABCC8 ATP6V0E2	9.04e-04	55	72	3	GO:0098533
GeneOntologyCellularComponent	IgA immunoglobulin complex	IGKV3D-15 IGKV3-15	1.19e-03	15	72	2	GO:0071745
GeneOntologyCellularComponent	IgM immunoglobulin complex	IGKV3D-15 IGKV3-15	1.19e-03	15	72	2	GO:0071753
GeneOntologyCellularComponent	immunoglobulin complex, circulating	IGKV3D-15 IGKV3-15	1.54e-03	17	72	2	GO:0042571
GeneOntologyCellularComponent	NADPH oxidase complex	NCF1C NCF1B	1.73e-03	18	72	2	GO:0043020
GeneOntologyCellularComponent	side of membrane	MPL LRRK2 MUC16 GNAQ CUBN NCF1C NCF1B CD209 CDH13	3.03e-03	875	72	9	GO:0098552
GeneOntologyCellularComponent	exocytic vesicle membrane	ABCC8 ATP6V0E2 LRRK2 BSN	3.40e-03	179	72	4	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	ABCC8 ATP6V0E2 LRRK2 BSN	3.40e-03	179	72	4	GO:0030672
GeneOntologyCellularComponent	multivesicular body	PGA4 LRRK2 PGA5	3.49e-03	88	72	3	GO:0005771
GeneOntologyCellularComponent	proton-transporting two-sector ATPase complex, proton-transporting domain	ATP6V0E1 ATP6V0E2	3.60e-03	26	72	2	GO:0033177
Domain	Cadherin_tail	PCDHA10 PCDHA8 PCDHA3 PCDHA2	8.60e-06	37	66	4	PF15974
Domain	Cadherin_CBD	PCDHA10 PCDHA8 PCDHA3 PCDHA2	8.60e-06	37	66	4	IPR031904
Domain	ATPase_V0-cplx_e1/e2_su	ATP6V0E1 ATP6V0E2	1.23e-05	2	66	2	IPR008389
Domain	ATPase_V0-cplx_e1/e2_su_met	ATP6V0E1 ATP6V0E2	1.23e-05	2	66	2	IPR017385
Domain	ATP_synt_H	ATP6V0E1 ATP6V0E2	1.23e-05	2	66	2	PF05493
Domain	Cadherin_CS	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	4.16e-05	109	66	5	IPR020894
Domain	CADHERIN_1	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	4.94e-05	113	66	5	PS00232
Domain	Cadherin	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	4.94e-05	113	66	5	PF00028
Domain	CADHERIN_2	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	5.15e-05	114	66	5	PS50268
Domain	-	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	5.15e-05	114	66	5	2.60.40.60
Domain	CA	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	5.37e-05	115	66	5	SM00112
Domain	Cadherin-like	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	5.60e-05	116	66	5	IPR015919
Domain	Cadherin	PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	6.07e-05	118	66	5	IPR002126
Domain	Cadherin_2	PCDHA10 PCDHA8 PCDHA3 PCDHA2	8.19e-05	65	66	4	PF08266
Domain	Cadherin_N	PCDHA10 PCDHA8 PCDHA3 PCDHA2	8.19e-05	65	66	4	IPR013164
Domain	-	LCTL AGL GBE1	2.54e-04	35	66	3	3.20.20.80
Domain	Aspartic_peptidase_N	PGA4 PGA5	2.55e-04	7	66	2	IPR012848
Domain	A1_Propeptide	PGA4 PGA5	2.55e-04	7	66	2	PF07966
Domain	Glyco_hydro_catalytic_dom	LCTL AGL GBE1	3.25e-04	38	66	3	IPR013781
Domain	Aspartic_peptidase_A1	PGA4 PGA5	5.43e-04	10	66	2	IPR001461
Domain	PEPTIDASE_A1	PGA4 PGA5	5.43e-04	10	66	2	IPR033121
Domain	Asp	PGA4 PGA5	5.43e-04	10	66	2	PF00026
Domain	PEPTIDASE_A1	PGA4 PGA5	5.43e-04	10	66	2	PS51767
Domain	-	PGA4 PGA5	7.93e-04	12	66	2	2.40.70.10
Domain	ASP_PROTEASE	PGA4 PGA5	7.93e-04	12	66	2	PS00141
Domain	Glycoside_hydrolase_SF	LCTL AGL GBE1	8.70e-04	53	66	3	IPR017853
Domain	Aspartic_peptidase_AS	PGA4 PGA5	9.36e-04	13	66	2	IPR001969
Domain	Peptidase_aspartic_dom	PGA4 PGA5	1.62e-03	17	66	2	IPR021109
Domain	JmjC	KDM3A KDM4E	3.23e-03	24	66	2	PF02373
Domain	JMJC	KDM3A KDM4E	5.70e-03	32	66	2	PS51184
Domain	JmjC_dom	KDM3A KDM4E	5.70e-03	32	66	2	IPR003347
Domain	JmjC	KDM3A KDM4E	6.05e-03	33	66	2	SM00558
Pathway	REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES	ATP6V0E1 ATP6V0E2 NCF1C NCF1B	1.84e-05	38	59	4	MM14519
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	2.26e-08	15	72	4	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	3.94e-08	17	72	4	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	5.05e-08	18	72	4	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	5.05e-08	18	72	4	10662547
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	1.74e-07	24	72	4	24698270
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	3.33e-07	28	72	4	15347688
Pubmed	MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion.	MUC16 NRP2	4.23e-06	2	72	2	35533267
Pubmed	Crystal structure of human pepsin and its complex with pepstatin.	PGA4 PGA5	4.23e-06	2	72	2	7663352
Pubmed	Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.	PGA4 PGA5	4.23e-06	2	72	2	2714789
Pubmed	Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component.	ATP6V0E1 ATP6V0E2	4.23e-06	2	72	2	17350184
Pubmed	CA-125 and CRP are elevated in preeclampsia.	MUC16 CRP	4.23e-06	2	72	2	19437230
Pubmed	Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells.	MPL NUDC	4.23e-06	2	72	2	17658515
Pubmed	Activation of human pepsinogens.	PGA4 PGA5	4.23e-06	2	72	2	3197840
Pubmed	A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl).	MPL NUDC	4.23e-06	2	72	2	16088917
Pubmed	The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling.	NTRK2 BSN	4.23e-06	2	72	2	34360710
Pubmed	Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation.	MPL NUDC	4.23e-06	2	72	2	19560457
Pubmed	Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis.	NTRK2 MUC16	4.23e-06	2	72	2	21079983
Pubmed	Functional pseudogenes inhibit the superoxide production.	NCF1C NCF1B	4.23e-06	2	72	2	26086043
Pubmed	Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.	PGA4 PGA5	4.23e-06	2	72	2	2415509
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	6.14e-06	57	72	4	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	6.58e-06	58	72	4	30377227
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA10 PCDHA8 PCDHA3 PCDHA2	1.24e-05	68	72	4	11230163
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1C NCF1B	1.27e-05	3	72	2	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1C NCF1B	1.27e-05	3	72	2	10678931
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1C NCF1B	1.27e-05	3	72	2	27044504
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1C NCF1B	1.27e-05	3	72	2	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1C NCF1B	1.27e-05	3	72	2	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1C NCF1B	1.27e-05	3	72	2	10891396
Pubmed	Close linkage of human chromosomal pepsinogen A genes.	PGA4 PGA5	1.27e-05	3	72	2	3017318
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1C NCF1B	1.27e-05	3	72	2	25474113
Pubmed	Serum pepsinogen test for early detection of gastric cancer in a European country.	PGA4 PGA5	1.27e-05	3	72	2	21989121
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1C NCF1B	1.27e-05	3	72	2	18787174
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1C NCF1B	1.27e-05	3	72	2	26209274
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1C NCF1B	1.27e-05	3	72	2	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1C NCF1B	1.27e-05	3	72	2	22184329
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1C NCF1B	1.27e-05	3	72	2	11018074
Pubmed	Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.	PGA4 PGA5	1.27e-05	3	72	2	9855083
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1C NCF1B	1.27e-05	3	72	2	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1C NCF1B	1.27e-05	3	72	2	20142487
Pubmed	Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.	PGA4 PGA5	1.27e-05	3	72	2	9797498
Pubmed	The glomerular sieving of pepsinogen A and C in man.	PGA4 PGA5	1.27e-05	3	72	2	2478370
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1C NCF1B	1.27e-05	3	72	2	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1C NCF1B	1.27e-05	3	72	2	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1C NCF1B	1.27e-05	3	72	2	21570954
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1C NCF1B	1.27e-05	3	72	2	25565313
Pubmed	Serum expression level of squamous cell carcinoma antigen, highly sensitive C-reactive protein, and CA-125 as potential biomarkers for recurrence of cervical cancer.	MUC16 CRP	1.27e-05	3	72	2	28901315
Pubmed	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PGA4 PGA5	1.27e-05	3	72	2	3815274
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1C NCF1B	1.27e-05	3	72	2	39357591
Pubmed	Pepsinogens: physiology, pharmacology pathophysiology and exercise.	PGA4 PGA5	1.27e-05	3	72	2	10675278
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1C NCF1B	1.27e-05	3	72	2	12958309
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1C NCF1B	1.27e-05	3	72	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1C NCF1B	1.27e-05	3	72	2	31118934
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1C NCF1B	1.27e-05	3	72	2	23482812
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1C NCF1B	1.27e-05	3	72	2	16041040
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1C NCF1B	1.27e-05	3	72	2	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1C NCF1B	1.27e-05	3	72	2	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1C NCF1B	1.27e-05	3	72	2	21435178
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1C NCF1B	1.27e-05	3	72	2	18703411
Pubmed	The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.	PGA4 PGA5	1.27e-05	3	72	2	7926498
Pubmed	Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.	PGA4 PGA5	1.27e-05	3	72	2	3780036
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1C NCF1B	1.27e-05	3	72	2	29228045
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1C NCF1B	1.27e-05	3	72	2	17307863
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1C NCF1B	1.27e-05	3	72	2	22155727
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1C NCF1B	1.27e-05	3	72	2	27829407
Pubmed	Crystal structure of human pepsinogen A.	PGA4 PGA5	1.27e-05	3	72	2	9561228
Pubmed	The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.	PGA4 PGA5	1.27e-05	3	72	2	21455714
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1C NCF1B	1.27e-05	3	72	2	24576409
Pubmed	Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.	PGA4 PGA5	1.27e-05	3	72	2	19800305
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1C NCF1B	1.27e-05	3	72	2	22376231
Pubmed	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	PGA4 PGA5	1.27e-05	3	72	2	2901984
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1C NCF1B	1.27e-05	3	72	2	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1C NCF1B	1.27e-05	3	72	2	28274989
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1C NCF1B	1.27e-05	3	72	2	26645958
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1C NCF1B	1.27e-05	3	72	2	12364355
Pubmed	Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.	PGA4 PGA5	1.27e-05	3	72	2	3839486
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1C NCF1B	1.27e-05	3	72	2	24549323
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1C NCF1B	1.27e-05	3	72	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1C NCF1B	1.27e-05	3	72	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1C NCF1B	1.27e-05	3	72	2	10670582
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1C NCF1B	1.27e-05	3	72	2	20881184
Pubmed	Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.	PGA4 PGA5	1.27e-05	3	72	2	24170207
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1C NCF1B	1.27e-05	3	72	2	26528554
Pubmed	Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.	PGA4 PGA5	1.27e-05	3	72	2	3467902
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1C NCF1B	1.27e-05	3	72	2	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1C NCF1B	1.27e-05	3	72	2	20864666
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1C NCF1B	1.27e-05	3	72	2	23328631
Pubmed	The pepsinogens of human gastric mucosa.	PGA4 PGA5	1.27e-05	3	72	2	4586732
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1C NCF1B	1.27e-05	3	72	2	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1C NCF1B	1.27e-05	3	72	2	17114280
Pubmed	Relationships between the human pepsinogen DNA and protein polymorphisms.	PGA4 PGA5	1.27e-05	3	72	2	3014868
Pubmed	Genomic structure and evolution of the human pepsinogen A multigene family.	PGA4 PGA5	1.27e-05	3	72	2	2892778
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1C NCF1B	1.27e-05	3	72	2	19168575
Pubmed	The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.	PGA4 PGA5	1.27e-05	3	72	2	24383519
Pubmed	Gene structures of pepsinogens A and C.	PGA4 PGA5	1.27e-05	3	72	2	1455184
Pubmed	Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.	PGA4 PGA5	1.27e-05	3	72	2	2831884
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1C NCF1B	1.27e-05	3	72	2	25989352
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1C NCF1B	1.27e-05	3	72	2	19503084
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1C NCF1B	1.27e-05	3	72	2	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1C NCF1B	1.27e-05	3	72	2	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1C NCF1B	1.27e-05	3	72	2	36592568
Interaction	PCDHA10 interactions	PCDHA10 PCDHA8 PCDHA3 PCDHA2	7.80e-07	22	67	4	int:PCDHA10
Interaction	PCDHA6 interactions	PCDHA10 PCDHA8 PCDHA3	2.91e-06	9	67	3	int:PCDHA6
Interaction	PCDHA3 interactions	MYCBP2 PCDHA10 PCDHA8 PCDHA3	4.80e-06	34	67	4	int:PCDHA3
Interaction	PCDHA7 interactions	PCDHA10 PCDHA8 PCDHA2	1.25e-05	14	67	3	int:PCDHA7
Interaction	PCDHA2 interactions	PCDHA10 PCDHA8 PCDHA2	1.25e-05	14	67	3	int:PCDHA2
Interaction	PCDHA8 interactions	PCDHA10 PCDHA8 PCDHA3 PCDHA2	3.35e-05	55	67	4	int:PCDHA8
Cytoband	5q31	PCDHA10 PCDHA8 PCDHA3 PCDHA2	3.37e-05	115	72	4	5q31
GeneFamily	Clustered protocadherins	PCDHA10 PCDHA8 PCDHA3 PCDHA2	1.31e-05	64	41	4	20
GeneFamily	V-type ATPases	ATP6V0E1 ATP6V0E2	1.23e-03	23	41	2	415
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM3A KDM4E	1.34e-03	24	41	2	485
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	CES5A ACRBP PCDHA10 PCDHA8 PCDHA3 MAEL PCDHA2	6.92e-06	261	71	7	MM1277
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GLS2 ACRBP LRRK2 PPIP5K1 PRR14L	7.82e-06	168	72	5	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	Pericytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SEMA5B NTRK2 NDUFA4L2 CDH13 COL1A2	1.15e-05	182	72	5	46c213597445b1f4f09dc367f27702d24b201daf
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA5B ABCC8 NDUFA4L2 CDH13 COL1A2	1.18e-05	183	72	5	4060d979948e1dd7507977629a7fbdfa4ca65bb6
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA5B ABCC8 NDUFA4L2 CDH13 COL1A2	1.18e-05	183	72	5	0d44a978221cf3f733704bf11863502805fba733
ToppCell	Mild-CD4+_T\|Mild / Disease group and Cell class	CNKSR1 FMN1 NTRK2 LRRK2 GNAQ	1.25e-05	185	72	5	c28ecb63146de1b02418e5a4fad0ae7c2b66a41d
ToppCell	Pericytes\|World / lung cells shred on cell class, cell subclass, sample id	SEMA5B NTRK2 NDUFA4L2 CDH13 COL1A2	1.49e-05	192	72	5	057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PLEKHG1 MYCBP2 ZNF318 NCF1C NCF1B	1.57e-05	194	72	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCC8 NTRK2 MUC16 NCF1C NCF1B	1.61e-05	195	72	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCC8 NTRK2 MUC16 NCF1C NCF1B	1.61e-05	195	72	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Macroglial-Glia_progenitor_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	KDM3A FUT11 ATP6V0E1 NDUFA4L2 GBE1	1.81e-05	200	72	5	1e1f4341b6dc17478a1cb8f625732e3008c2ec8a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Macroglial-Glia_progenitor_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	CLGN ATP6V0E1 NTRK2 NDUFA4L2 GBE1	1.81e-05	200	72	5	4859fbe663ae9372fc8ed3b4e1fa301e06621a31
Disease	1,5 anhydroglucitol measurement	PCDHA10 PCDHA8 PCDHA3 PCDHA2	5.86e-07	29	68	4	EFO_0008009
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1C NCF1B CRP	2.54e-06	12	68	3	DOID:7148 (implicated_via_orthology)
Disease	Glycogen Storage Disease Type III	AGL GBE1	5.23e-06	2	68	2	C0017922
Disease	visceral adipose tissue measurement, body mass index	PCDHA10 PCDHA8 PCDHA3 PCDHA2	4.97e-05	87	68	4	EFO_0004340, EFO_0004765
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1C NCF1B	5.21e-05	5	68	2	DOID:3265 (implicated_via_orthology)
Disease	neutrophil count, basophil count	COQ8A PCDHA10 PCDHA8 PCDHA3 PCDHA2	1.70e-04	224	68	5	EFO_0004833, EFO_0005090
Disease	Tinnitus	FMN1 ZNF318 SDK1 CDH13	2.35e-04	130	68	4	HP_0000360
Disease	alcohol and nicotine codependence	PLEKHG1 CAPN7	4.02e-04	13	68	2	EFO_0004776
Disease	Glycogen storage disease	AGL GBE1	6.96e-04	17	68	2	cv:C0017919
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA3 PCDHA2	9.10e-04	82	68	3	EFO_0008535
Disease	cortical thickness	FNIP2 PLEKHG1 GLS2 MYCBP2 CEP112 ARFGEF2 MAEL ZNF318 NRP2	9.99e-04	1113	68	9	EFO_0004840
Disease	Sjogren's syndrome (is_marker_for)	MUC16 CRP	1.40e-03	24	68	2	DOID:12894 (is_marker_for)
Disease	eye colour measurement	CES5A MYCBP2 CEP112 COL1A2	1.63e-03	218	68	4	EFO_0009764
Disease	unipolar depression, depressive symptom measurement	FNIP2 ARFGEF2	1.64e-03	26	68	2	EFO_0003761, EFO_0007006
Disease	blood rubidium measurement	ARFGEF2 CDH13	1.64e-03	26	68	2	EFO_0021529
Disease	Glycogen Storage Disease	AGL GBE1	1.77e-03	27	68	2	C0017919
Disease	Alzheimer disease, gastroesophageal reflux disease	PCDHA3 PCDHA2 SDK1 IQCK	1.92e-03	228	68	4	EFO_0003948, MONDO_0004975
Disease	neuroticism measurement, cognitive function measurement	GBE1 PCDHA10 PCDHA8 PCDHA3 PCDHA2 CDH13	1.94e-03	566	68	6	EFO_0007660, EFO_0008354
Disease	cervical cancer (is_implicated_in)	KDM3A CDH13	2.18e-03	30	68	2	DOID:4362 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WKNKYAINESQRPPD	BDP1	166	A6H8Y1
KLANQASNYAEPPWA	nan	501	Q9N2K0
YSQRELFEPWNNLPK	APOBEC3G	166	Q9HC16
SYWRNQNPGSLLQLP	ACRBP	306	Q8NEB7
QLSNPTDDSWKGRPY	ARFGEF2	1526	Q9Y6D5
WNLGIENPRYLRQKP	CEP112	211	Q8N8E3
NKLRYPPNSQSKVDW	ALDH3A2	436	P51648
DGSPLLPSFKQYWNR	CD209	331	Q9NNX6
LPSFKQYWNRGEPNN	CD209	336	Q9NNX6
VYKDPAGWLNINPIN	CDH13	516	P55290
LNAKATGYQELPDWP	AP3B2	631	Q13367
WDGFNEQTPKDLPNR	FMN1	631	Q68DA7
TEWLYNQNPKRAGEP	IQCK	171	Q8N0W5
NPYVDAIKSLWNDPG	GNAQ	126	P50148
KPRQPNPDWRYSASL	PCDHA2	796	Q9Y5H9
NLNPARKYFPQWEAP	PGA5	46	P0DJD9
NWGKLAEAYLNLGPA	C8orf76	166	Q96K31
LDPKSPGLNREQLYW	MUC16	12306	Q8WXI7
LDPKSPGLNREQLYW	MUC16	12931	Q8WXI7
GLKPRQPNPDWRYSA	PCDHA8	796	Q9Y5H6
SAKPRQPNPDWRYSA	PCDHA3	796	Q9Y5H8
LNQWRNGYSPICKPQ	KANSL1L	681	A0AUZ9
NPGNWPPIYCKSDDR	MAEL	206	Q96JY0
FNRDPNLGYPLWRLK	HIPK1	426	Q86Z02
NLEGKPILFFWQNSP	LIPT1	56	Q9Y234
AAAELAQNGQYWPPL	BSN	2491	Q9UPA5
NGFPNPREVESWYLK	LCTL	501	Q6UWM7
NPRWNGDKLYNEARK	EPX	406	P11678
PNGNDLSLWPAYNLT	CES5A	501	Q6NT32
NGWTPNLDSNKEYLQ	NRP2	316	O60462
ADPKPYWNQALQELR	FGFBP2	86	Q9BYJ0
EKDLPNYNWNSFGLR	KISS1	106	Q15726
ADLEQRYWKSHPGNP	KDM4E	116	B2RXH2
NDIQYLPGPAHWKSL	LRRK2	1206	Q5S007
AYIPQLAKSNPDLWG	GLS2	181	Q9UI32
SNLAWYQQKPGQAPR	IGKV3D-15	51	A0A087WSY6
LPAPKWFDGQRAAEN	NCF1B	76	A6NI72
LPAPKWFDGQRAAEN	NCF1C	51	A8MVU1
WFQQKPGQAPRALIY	IGLV7-43	56	P04211
KPRQPNPDWRYSASL	PCDHA10	796	Q9Y5I2
PEPWNRLSPNDQYKF	NDUFA4L2	56	Q9NRX3
LRSPGWPDNYDNDKD	CUBN	3406	O60494
GWAPFDKNNYQQLLG	SLC37A1	86	P57057
AQPENIPAKNWYRSS	COL1A2	1206	P08123
PEWLDFPRKGNNESY	GBE1	546	Q04446
TPNKYDNEAIGLWLP	KDM3A	591	Q9Y4C1
NWTPELQKYLNFDPR	CAPN7	496	Q9Y6W3
REWGVNDPLLPNYLN	FUT11	371	Q495W5
AKTHPYNPLWAQLGD	FNIP2	476	Q9P278
LNNDLGPNWRDKLEY	COQ8A	316	Q8NI60
GPFSPNVLNWRALKY	CRP	196	P02741
SNLAWYQQKPGQAPR	IGKV3-15	51	P01624
INQGYKLLAWPADAP	SDK1	901	Q7Z5N4
KWNEIYGNNLPPLAL	DSEL	116	Q8IZU8
SELLPAGWNNNKDLY	PSMF1	51	Q92530
NPYLAASGWDKRPNS	PRR14L	1671	Q5THK1
NLNPARKYFPQWEAP	PGA4	46	P0DJD7
EPWPENATLYQQLKG	MTX2	16	O75431
AKFPFNQWGLQPRSL	MRPS15	31	P82914
NPLFGPQLKNETIWY	ATP6V0E1	61	O15342
ARWLQPDSYADPQKT	MYCBP2	2256	O75592
PNLGNGADLPNYRWT	NUDC	161	Q9Y266
RGPVAYASQKPWLLN	ABCC8	766	Q09428
LVDNPNYQGIWSPRK	CLGN	376	O14967
YPFEDWQLPGKNLLQ	CNKSR1	26	Q969H4
PKPALQWFYNGAILN	NTRK2	311	Q16620
WYNPRPLEGNVHLKS	nan	126	A8MX80
PLNPNPDSRWNTYFK	TBC1D13	101	Q9NVG8
NPLFGPQLKNETIWY	ATP6V0E2	61	Q8NHE4
PLRTAQYNSKWLNEP	SEMA5B	271	Q9P283
LQPGNSYWLQLRSEP	MPL	246	P40238
WYNPRPLEGNVHLKS	nan	96	A8MV72
WYNPRPLEGNVHLKS	nan	126	Q8N9G6
WYNPRPLEGNVHLKS	nan	126	A8MUI8
WYNPRPLEGNVHLKS	nan	126	A8MUA0
YKWQNSPDNPQRFDR	TRIM10	336	Q9UDY6
DKLNDYLWRGPSPNQ	PLEKHG1	1351	Q9ULL1
TALKEPQGNLYQWGP	ZNF318	441	Q5VUA4
QLQQRSEKPPWYSSG	PPIP5K1	1156	Q6PFW1
LNPDFSRPNRKYTWN	AGL	181	P35573
PWKGLPELTNENAQY	AGL	1496	P35573