Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptide lactyltransferase (CoA-dependent) activity	CREBBP EP300	1.25e-05	2	71	2	GO:0120300
GeneOntologyMolecularFunction	histone H3K27 acetyltransferase activity	CREBBP EP300	1.25e-05	2	71	2	GO:0044017
GeneOntologyMolecularFunction	histone H3K18 acetyltransferase activity	CREBBP EP300	3.73e-05	3	71	2	GO:0043993
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPY4R2 NPY4R SORCS2 NMUR1	3.77e-05	53	71	4	GO:0008188
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	7.44e-05	4	71	2	GO:0001602
GeneOntologyMolecularFunction	neuropeptide binding	NPY4R2 NPY4R NMUR1	3.07e-04	37	71	3	GO:0042923
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	6.72e-04	11	71	2	GO:0004983
GeneOntologyMolecularFunction	myosin II binding	LLGL1 STXBP5L	9.48e-04	13	71	2	GO:0045159
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	CREBBP EP300	1.27e-03	15	71	2	GO:0010484
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPY4R2 NPY4R SORCS2 NMUR1	1.29e-03	133	71	4	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPY4R2 NPY4R SORCS2 NMUR1	1.56e-03	140	71	4	GO:0001653
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	CREBBP EP300	2.51e-03	21	71	2	GO:0042975
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA3A SEMA4D	3.01e-03	23	71	2	GO:0030215
GeneOntologyMolecularFunction	transition metal ion binding	UBR2 LACTB2 CYP11A1 RPTN TLL2 MMP23B CA13 HDAC10 ERVK-24 CREBBP EP300	3.03e-03	1189	71	11	GO:0046914
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	TGFB2 SEMA3A PARP6 SEMA4D LLGL1 KALRN CNTNAP2 SLC30A1 EP300 PLXNA1 NIN	3.08e-05	748	68	11	GO:0048667
GeneOntologyBiologicalProcess	dendrite morphogenesis	SEMA3A PARP6 SEMA4D KALRN CNTNAP2 SLC30A1	4.84e-05	198	68	6	GO:0048813
GeneOntologyBiologicalProcess	neuron projection morphogenesis	TGFB2 SEMA3A PARP6 SEMA4D LLGL1 KALRN CNTNAP2 SLC30A1 EP300 PLXNA1 NIN	5.80e-05	802	68	11	GO:0048812
GeneOntologyBiologicalProcess	N-terminal peptidyl-lysine acetylation	CREBBP EP300	6.40e-05	4	68	2	GO:0018076
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	TGFB2 SEMA3A PARP6 SEMA4D LLGL1 KALRN CNTNAP2 SLC30A1 EP300 PLXNA1 NIN	7.01e-05	819	68	11	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	TGFB2 SEMA3A PARP6 SEMA4D LLGL1 KALRN CNTNAP2 SLC30A1 EP300 PLXNA1 NIN	7.56e-05	826	68	11	GO:0048858
GeneOntologyBiologicalProcess	axonogenesis	TGFB2 SEMA3A SEMA4D LLGL1 KALRN CNTNAP2 EP300 PLXNA1 NIN	9.66e-05	566	68	9	GO:0007409
GeneOntologyBiologicalProcess	dichotomous subdivision of terminal units involved in salivary gland branching	SEMA3A PLXNA1	1.06e-04	5	68	2	GO:0060666
GeneOntologyBiologicalProcess	dendrite development	SEMA3A PARP6 SEMA4D KALRN CNTNAP2 SLC30A1 CREBBP	1.16e-04	335	68	7	GO:0016358
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	PARP6 SEMA4D KALRN SLC30A1 EP300 PLXNA1 NIN	1.63e-04	354	68	7	GO:0050769
GeneOntologyBiologicalProcess	gonadotrophin-releasing hormone neuronal migration to the hypothalamus	SEMA3A PLXNA1	2.23e-04	7	68	2	GO:0021828
GeneOntologyBiologicalProcess	hypothalamic tangential migration using cell-axon interactions	SEMA3A PLXNA1	2.23e-04	7	68	2	GO:0021856
GeneOntologyBiologicalProcess	axon development	TGFB2 SEMA3A SEMA4D LLGL1 KALRN CNTNAP2 EP300 PLXNA1 NIN	2.48e-04	642	68	9	GO:0061564
GeneOntologyBiologicalProcess	regulation of neurogenesis	SEMA3A PARP6 SEMA4D KALRN SLC30A1 EP300 PLXNA1 NIN	2.84e-04	515	68	8	GO:0050767
GeneOntologyBiologicalProcess	regulation of dendrite morphogenesis	PARP6 SEMA4D KALRN SLC30A1	3.74e-04	103	68	4	GO:0048814
GeneOntologyBiologicalProcess	hypothalamus cell migration	SEMA3A PLXNA1	3.80e-04	9	68	2	GO:0021855
GeneOntologyBiologicalProcess	hypothalamus gonadotrophin-releasing hormone neuron differentiation	SEMA3A PLXNA1	3.80e-04	9	68	2	GO:0021886
GeneOntologyBiologicalProcess	hypothalamus gonadotrophin-releasing hormone neuron development	SEMA3A PLXNA1	3.80e-04	9	68	2	GO:0021888
GeneOntologyBiologicalProcess	regulation of axonogenesis	SEMA3A SEMA4D EP300 PLXNA1 NIN	4.30e-04	192	68	5	GO:0050770
GeneOntologyBiologicalProcess	positive regulation of nervous system development	PARP6 SEMA4D KALRN SLC30A1 EP300 PLXNA1 NIN	4.47e-04	418	68	7	GO:0051962
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	SMG1 NBAS UPF2	4.70e-04	46	68	3	GO:0000184
HumanPheno	Plantar crease between first and second toes	CREBBP EP300	3.13e-05	2	29	2	HP:0008107
HumanPheno	Aortic isthmus hypoplasia	CREBBP EP300	3.13e-05	2	29	2	HP:0034227
HumanPheno	High axial triradius	CREBBP EP300	3.13e-05	2	29	2	HP:0001042
HumanPheno	Laryngeal cartilage malformation	CREBBP EP300	9.36e-05	3	29	2	HP:0008752
HumanPheno	Phobia	CREBBP EP300	9.36e-05	3	29	2	HP:5200232
HumanPheno	Agoraphobia	CREBBP EP300	9.36e-05	3	29	2	HP:0000756
HumanPheno	Humoral immunodeficiency	CREBBP EP300	9.36e-05	3	29	2	HP:0005363
HumanPheno	Prominent nasal septum	CREBBP EP300	9.36e-05	3	29	2	HP:0005322
HumanPheno	Radial deviation of thumb terminal phalanx	CREBBP EP300	9.36e-05	3	29	2	HP:0005895
HumanPheno	Trichiasis	CREBBP EP300	1.86e-04	4	29	2	HP:0001128
HumanPheno	Visceral hemangioma	CREBBP EP300	1.86e-04	4	29	2	HP:0410266
HumanPheno	Talon cusp	CREBBP EP300	1.86e-04	4	29	2	HP:0011087
HumanPheno	Widened distal phalanges	CREBBP EP300	1.86e-04	4	29	2	HP:0006200
HumanPheno	Vascular ring	CREBBP EP300	1.86e-04	4	29	2	HP:0010775
HumanPheno	Hepatic hemangioma	CREBBP EP300	1.86e-04	4	29	2	HP:0031207
HumanPheno	Brain imaging abnormality	FOCAD SIN3B ABCD1 SIM1 CREBBP EP300	2.88e-04	167	29	6	HP:0410263
HumanPheno	Adrenocorticotropic hormone excess	CYP11A1 ABCD1	3.10e-04	5	29	2	HP:0011749
HumanPheno	Papillary cystadenoma of the epididymis	CREBBP EP300	3.10e-04	5	29	2	HP:0009715
HumanPheno	Achromatopsia	NBAS ATF6	3.10e-04	5	29	2	HP:0011516
HumanPheno	Supernumerary cusp	CREBBP EP300	3.10e-04	5	29	2	HP:0033777
HumanPheno	Epididymal neoplasm	CREBBP EP300	3.10e-04	5	29	2	HP:0030421
HumanPheno	Hip dysplasia	HIVEP2 LGI3 MMP23B SIM1 CREBBP EP300 NIN	3.61e-04	247	29	7	HP:0001385
HumanPheno	Large foramen magnum	CREBBP EP300	4.63e-04	6	29	2	HP:0002700
Domain	-	SEMA3A WDR3 NBAS SEMA4D LLGL1 RBBP4 STXBP5L NUP133 WDR77 WDFY2 PLXNA1	4.16e-08	333	70	11	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA3A WDR3 NBAS SEMA4D LLGL1 RBBP4 STXBP5L NUP133 WDR77 WDFY2 PLXNA1	4.42e-08	335	70	11	IPR015943
Domain	Nuc_rcpt_coact_CREBbp	CREBBP EP300	1.38e-05	2	70	2	IPR014744
Domain	HAT_KAT11	CREBBP EP300	1.38e-05	2	70	2	PF08214
Domain	KIX	CREBBP EP300	1.38e-05	2	70	2	PS50952
Domain	ZnF_TAZ	CREBBP EP300	1.38e-05	2	70	2	SM00551
Domain	CBP_P300_HAT	CREBBP EP300	1.38e-05	2	70	2	IPR031162
Domain	DUF902	CREBBP EP300	1.38e-05	2	70	2	PF06001
Domain	-	CREBBP EP300	1.38e-05	2	70	2	1.20.1020.10
Domain	RING_CBP-p300	CREBBP EP300	1.38e-05	2	70	2	IPR010303
Domain	-	CREBBP EP300	1.38e-05	2	70	2	1.10.1630.10
Domain	Creb_binding	CREBBP EP300	1.38e-05	2	70	2	PF09030
Domain	NPY4_rcpt	NPY4R2 NPY4R	1.38e-05	2	70	2	IPR001933
Domain	-	CREBBP EP300	1.38e-05	2	70	2	1.10.246.20
Domain	zf-TAZ	CREBBP EP300	1.38e-05	2	70	2	PF02135
Domain	ZF_TAZ	CREBBP EP300	1.38e-05	2	70	2	PS50134
Domain	Histone_AcTrfase_Rtt109/CBP	CREBBP EP300	1.38e-05	2	70	2	IPR013178
Domain	KAT11	CREBBP EP300	1.38e-05	2	70	2	SM01250
Domain	Znf_TAZ	CREBBP EP300	1.38e-05	2	70	2	IPR000197
Domain	KIX_dom	CREBBP EP300	1.38e-05	2	70	2	IPR003101
Domain	KIX	CREBBP EP300	1.38e-05	2	70	2	PF02172
Domain	CBP_P300_HAT	CREBBP EP300	1.38e-05	2	70	2	PS51727
Domain	WD40_repeat_CS	WDR3 LLGL1 RBBP4 STXBP5L WDR77 WDFY2	3.45e-05	164	70	6	IPR019775
Domain	WD_REPEATS_1	WDR3 NBAS LLGL1 RBBP4 STXBP5L WDR77 WDFY2	8.08e-05	278	70	7	PS00678
Domain	WD_REPEATS_2	WDR3 NBAS LLGL1 RBBP4 STXBP5L WDR77 WDFY2	8.26e-05	279	70	7	PS50082
Domain	WD_REPEATS_REGION	WDR3 NBAS LLGL1 RBBP4 STXBP5L WDR77 WDFY2	8.26e-05	279	70	7	PS50294
Domain	LLGL	LLGL1 STXBP5L	8.27e-05	4	70	2	PF08366
Domain	Lethal2_giant	LLGL1 STXBP5L	8.27e-05	4	70	2	IPR000664
Domain	LLGL2	LLGL1 STXBP5L	8.27e-05	4	70	2	IPR013577
Domain	Nuc_rcpt_coact	CREBBP EP300	2.06e-04	6	70	2	IPR009110
Domain	Sema	SEMA3A SEMA4D PLXNA1	2.10e-04	31	70	3	SM00630
Domain	Semap_dom	SEMA3A SEMA4D PLXNA1	2.10e-04	31	70	3	IPR001627
Domain	Sema	SEMA3A SEMA4D PLXNA1	2.10e-04	31	70	3	PF01403
Domain	SEMA	SEMA3A SEMA4D PLXNA1	2.10e-04	31	70	3	PS51004
Domain	WD40	WDR3 LLGL1 RBBP4 STXBP5L WDR77 WDFY2	4.19e-04	259	70	6	PF00400
Domain	NPY_rcpt	NPY4R2 NPY4R	4.90e-04	9	70	2	IPR000611
Domain	WD40	WDR3 LLGL1 RBBP4 STXBP5L WDR77 WDFY2	5.02e-04	268	70	6	SM00320
Domain	WD40_repeat	WDR3 LLGL1 RBBP4 STXBP5L WDR77 WDFY2	5.42e-04	272	70	6	IPR001680
Domain	PSI	SEMA3A SEMA4D PLXNA1	5.98e-04	44	70	3	IPR016201
Domain	PSI	SEMA3A SEMA4D PLXNA1	6.82e-04	46	70	3	SM00423
Domain	WD40_repeat_dom	WDR3 LLGL1 RBBP4 STXBP5L WDR77 WDFY2	8.59e-04	297	70	6	IPR017986
Domain	ZZ	CREBBP EP300	2.04e-03	18	70	2	PF00569
Domain	ZF_ZZ_2	CREBBP EP300	2.04e-03	18	70	2	PS50135
Domain	ZF_ZZ_1	CREBBP EP300	2.04e-03	18	70	2	PS01357
Domain	Znf_ZZ	CREBBP EP300	2.27e-03	19	70	2	IPR000433
Domain	ZnF_ZZ	CREBBP EP300	2.27e-03	19	70	2	SM00291
Domain	Semaphorin	SEMA3A SEMA4D	2.52e-03	20	70	2	IPR027231
Domain	PAS_fold_3	SIM1 NPAS1	3.33e-03	23	70	2	IPR013655
Domain	PAS_3	SIM1 NPAS1	3.33e-03	23	70	2	PF08447
Domain	PAS-assoc_C	SIM1 NPAS1	3.62e-03	24	70	2	IPR000700
Domain	PAS	SIM1 NPAS1	3.93e-03	25	70	2	PF00989
Domain	PAS_fold	SIM1 NPAS1	3.93e-03	25	70	2	IPR013767
Domain	G-protein_beta_WD-40_rep	WDR3 RBBP4 WDFY2	4.00e-03	85	70	3	IPR020472
Domain	PAC	SIM1 NPAS1	4.25e-03	26	70	2	IPR001610
Domain	Bromodomain_CS	CREBBP EP300	4.25e-03	26	70	2	IPR018359
Domain	PAC	SIM1 NPAS1	4.25e-03	26	70	2	SM00086
Domain	PAC	SIM1 NPAS1	4.25e-03	26	70	2	PS50113
Domain	ZnMc	TLL2 MMP23B	5.27e-03	29	70	2	SM00235
Domain	Peptidase_Metallo	TLL2 MMP23B	5.27e-03	29	70	2	IPR006026
Domain	PSI	SEMA4D PLXNA1	6.39e-03	32	70	2	PF01437
Domain	Plexin_repeat	SEMA4D PLXNA1	6.39e-03	32	70	2	IPR002165
Domain	PAS	SIM1 NPAS1	6.39e-03	32	70	2	SM00091
Pathway	PID_HDAC_CLASSI_PATHWAY	SIN3B RBBP4 HDAC10 CREBBP WDR77 EP300	1.44e-07	66	52	6	M101
Pathway	BIOCARTA_TGFB_PATHWAY	TGFB2 CREBBP EP300	3.10e-05	17	52	3	MM1509
Pathway	BIOCARTA_TGFB_PATHWAY	TGFB2 CREBBP EP300	4.40e-05	19	52	3	M18933
Pathway	WP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX	CREBBP EP300 GABPB1	6.01e-05	21	52	3	M39593
Pathway	PID_RB_1PATHWAY	TGFB2 RBBP4 CREBBP EP300	9.44e-05	65	52	4	M279
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	1.33e-04	5	52	2	MM1575
Pathway	REACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES	CREBBP EP300	1.33e-04	5	52	2	M48020
Pathway	REACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES	CREBBP EP300	1.33e-04	5	52	2	M48023
Pathway	REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION	CREBBP EP300	1.33e-04	5	52	2	M27228
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	1.98e-04	6	52	2	M22062
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	SIN3B RBBP4 CREBBP EP300	2.33e-04	82	52	4	M2
Pathway	WP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA	TGFB2 CREBBP EP300	2.61e-04	34	52	3	M39771
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	2.77e-04	7	52	2	MM1573
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	3.68e-04	8	52	2	M22058
Pathway	REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES	CREBBP EP300	3.68e-04	8	52	2	M48022
Pathway	REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION	CREBBP EP300	3.68e-04	8	52	2	M48024
Pathway	REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES	CREBBP EP300	3.68e-04	8	52	2	M46443
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	CREBBP EP300	4.73e-04	9	52	2	M47451
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	CREBBP EP300	5.89e-04	10	52	2	M27945
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	7.19e-04	11	52	2	MM1521
Pathway	REACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES	CREBBP EP300	7.19e-04	11	52	2	M48021
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR	CREBBP EP300	7.19e-04	11	52	2	M26924
Pathway	PID_HEDGEHOG_GLI_PATHWAY	SIN3B RBBP4 CREBBP	7.28e-04	48	52	3	M219
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	HDAC10 CREBBP EP300	7.28e-04	48	52	3	M611
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	8.60e-04	12	52	2	M7968
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	CREBBP EP300	8.60e-04	12	52	2	M27765
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	SIN3B APOA5 CREBBP EP300	9.26e-04	118	52	4	M27316
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	TGFB2 SEMA3A PLXNA1	1.03e-03	54	52	3	M42568
Pathway	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	SEMA4D PLXNA1	1.18e-03	14	52	2	MM15047
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	CREBBP EP300	1.18e-03	14	52	2	M27808
Pathway	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	SEMA3A PLXNA1	1.18e-03	14	52	2	M7578
Pathway	REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER	HDAC10 CREBBP EP300	1.27e-03	58	52	3	M29616
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	1.36e-03	15	52	2	MM1339
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	1.36e-03	15	52	2	M10183
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	1.36e-03	15	52	2	MM1439
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	CREBBP EP300	1.36e-03	15	52	2	M953
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	SEMA3A PLXNA1	1.55e-03	16	52	2	M16498
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	CREBBP EP300	1.55e-03	16	52	2	M27121
Pathway	REACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS	RBBP4 EP300	1.55e-03	16	52	2	M26971
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	1.55e-03	16	52	2	M1296
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	1.55e-03	16	52	2	MM1420
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	1.55e-03	16	52	2	M8516
Pathway	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	SEMA3A PLXNA1	1.55e-03	16	52	2	M8245
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	CREBBP EP300	1.55e-03	16	52	2	M27940
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	SEMA3A SEMA4D PLXNA1	1.68e-03	64	52	3	M7923
Pathway	REACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA	CREBBP EP300	1.75e-03	17	52	2	M48025
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	CREBBP EP300	1.97e-03	18	52	2	M26942
Pathway	KEGG_RENAL_CELL_CARCINOMA	TGFB2 CREBBP EP300	2.18e-03	70	52	3	M13266
Pathway	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	SEMA4D PLXNA1	2.19e-03	19	52	2	M10959
Pathway	REACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES	CREBBP EP300	2.19e-03	19	52	2	M46442
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	CREBBP EP300	2.43e-03	20	52	2	M27881
Pathway	PID_E2F_PATHWAY	RBBP4 CREBBP EP300	2.45e-03	73	52	3	M40
Pathway	REACTOME_SIGNALING_BY_NOTCH1	HDAC10 CREBBP EP300	2.55e-03	74	52	3	M616
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	CREBBP EP300	2.68e-03	21	52	2	M27485
Pathway	BIOCARTA_VDR_PATHWAY	CREBBP EP300	2.94e-03	22	52	2	MM1370
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	2.94e-03	22	52	2	MM1443
Pathway	WP_CLOCKCONTROLLED_AUTOPHAGY_IN_BONE_METABOLISM	SEMA3A SEMA4D RB1CC1	3.18e-03	80	52	3	M45523
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	RBBP4 HDAC10 CREBBP WDR77 EP300	3.20e-03	272	52	5	M29619
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	3.21e-03	23	52	2	M2821
Pubmed	Regulation of murine TGFbeta2 by Pax3 during early embryonic development.	TGFB2 CREBBP EP300	8.48e-08	5	72	3	16787918
Pubmed	GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.	CREBBP EP300 GABPB1	8.48e-08	5	72	3	9990060
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FOCAD WDR3 SEMA4D ATF6 HIVEP2 WIZ KALRN VPS39 LGI3 KRT222 CADPS2 CREBBP EP300 XAB2	3.32e-07	1285	72	14	35914814
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA3A SEMA4D SIM1 PLXNA1	3.33e-07	28	72	4	18617019
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD HIVEP2 WIZ SH3TC1 KALRN VPS39 TMEM94 OBSCN DIP2C ABCD1 EP300 PLXNA1	2.64e-06	1105	72	12	35748872
Pubmed	Loss of p300 accelerates MDS-associated leukemogenesis.	CREBBP EP300	4.23e-06	2	72	2	27881875
Pubmed	Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.	CREBBP EP300	4.23e-06	2	72	2	34845315
Pubmed	Candidate gene analysis of semaphorins in patients with Alzheimer's disease.	SEMA3A SEMA4D	4.23e-06	2	72	2	19957197
Pubmed	p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.	CREBBP EP300	4.23e-06	2	72	2	19729597
Pubmed	Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.	CREBBP EP300	4.23e-06	2	72	2	15860545
Pubmed	Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.	CREBBP EP300	4.23e-06	2	72	2	29460469
Pubmed	Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.	CREBBP EP300	4.23e-06	2	72	2	24551300
Pubmed	Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.	CREBBP EP300	4.23e-06	2	72	2	33911074
Pubmed	The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.	CREBBP EP300	4.23e-06	2	72	2	9018065
Pubmed	Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.	CREBBP EP300	4.23e-06	2	72	2	24648406
Pubmed	CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.	CREBBP EP300	4.23e-06	2	72	2	30135524
Pubmed	CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.	CREBBP EP300	4.23e-06	2	72	2	39287984
Pubmed	Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.	CREBBP EP300	4.23e-06	2	72	2	16596650
Pubmed	The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.	CREBBP EP300	4.23e-06	2	72	2	29217654
Pubmed	Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.	CREBBP EP300	4.23e-06	2	72	2	20717166
Pubmed	Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.	CREBBP EP300	4.23e-06	2	72	2	10049825
Pubmed	CBP/p300 acetyltransferase activity in hematologic malignancies.	CREBBP EP300	4.23e-06	2	72	2	27380996
Pubmed	CREBBP and p300 lysine acetyl transferases in the DNA damage response.	CREBBP EP300	4.23e-06	2	72	2	29170789
Pubmed	The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.	CREBBP EP300	4.23e-06	2	72	2	25893291
Pubmed	Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.	CREBBP EP300	4.23e-06	2	72	2	11559821
Pubmed	Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.	CREBBP EP300	4.23e-06	2	72	2	21555743
Pubmed	CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.	CREBBP EP300	4.23e-06	2	72	2	12646247
Pubmed	CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.	CREBBP EP300	4.23e-06	2	72	2	32576962
Pubmed	Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.	CREBBP EP300	4.23e-06	2	72	2	19822209
Pubmed	A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.	CREBBP EP300	4.23e-06	2	72	2	24522976
Pubmed	Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.	CREBBP EP300	4.23e-06	2	72	2	11867645
Pubmed	CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.	CREBBP EP300	4.23e-06	2	72	2	21847097
Pubmed	Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.	CREBBP EP300	4.23e-06	2	72	2	11963968
Pubmed	p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.	CREBBP EP300	4.23e-06	2	72	2	34813504
Pubmed	Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.	CREBBP EP300	4.23e-06	2	72	2	9528808
Pubmed	Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.	CREBBP EP300	4.23e-06	2	72	2	12696060
Pubmed	RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.	RBBP4 EP300	4.23e-06	2	72	2	35231103
Pubmed	Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.	RB1CC1 CREBBP	4.23e-06	2	72	2	36394358
Pubmed	Rubinstein-Taybi Syndrome	CREBBP EP300	4.23e-06	2	72	2	20301699
Pubmed	CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.	CREBBP EP300	4.23e-06	2	72	2	36109165
Pubmed	Potential biomarker of metformin action.	CREBBP EP300	4.23e-06	2	72	2	24639469
Pubmed	The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.	CREBBP EP300	4.23e-06	2	72	2	37816914
Pubmed	Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.	GABPB2 GABPB1	4.23e-06	2	72	2	22862946
Pubmed	Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.	CREBBP EP300	4.23e-06	2	72	2	12242694
Pubmed	Binding of p300/CBP co-activators by polyoma large T antigen.	CREBBP EP300	4.23e-06	2	72	2	11438528
Pubmed	Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.	CREBBP EP300	4.23e-06	2	72	2	10918613
Pubmed	CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.	CREBBP EP300	4.23e-06	2	72	2	31182547
Pubmed	Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients.	LLGL1 CNTNAP2	4.23e-06	2	72	2	28628235
Pubmed	Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.	CREBBP EP300	4.23e-06	2	72	2	35502657
Pubmed	Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.	CREBBP EP300	4.23e-06	2	72	2	30635043
Pubmed	p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.	CREBBP EP300	4.23e-06	2	72	2	31898871
Pubmed	Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.	CREBBP EP300	4.23e-06	2	72	2	27648933
Pubmed	Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.	CREBBP EP300	4.23e-06	2	72	2	30888860
Pubmed	Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.	CREBBP EP300	4.23e-06	2	72	2	27881443
Pubmed	Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.	CREBBP EP300	4.23e-06	2	72	2	19272189
Pubmed	Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.	CREBBP EP300	4.23e-06	2	72	2	10610021
Pubmed	Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.	CREBBP EP300	4.23e-06	2	72	2	37314181
Pubmed	Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.	CREBBP EP300	4.23e-06	2	72	2	12397173
Pubmed	CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.	CREBBP EP300	4.23e-06	2	72	2	15641773
Pubmed	Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.	CREBBP EP300	4.23e-06	2	72	2	32690000
Pubmed	Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.	CREBBP EP300	4.23e-06	2	72	2	9733868
Pubmed	CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.	CREBBP EP300	4.23e-06	2	72	2	30953353
Pubmed	Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.	CREBBP EP300	4.23e-06	2	72	2	21803292
Pubmed	HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.	CREBBP EP300	4.23e-06	2	72	2	9811832
Pubmed	Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.	CREBBP EP300	4.23e-06	2	72	2	24089570
Pubmed	Rubinstein-Taybi syndrome in Chinese population with four novel mutations.	CREBBP EP300	4.23e-06	2	72	2	33063428
Pubmed	EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.	CREBBP EP300	4.23e-06	2	72	2	34506759
Pubmed	Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.	CREBBP EP300	4.23e-06	2	72	2	22177454
Pubmed	Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.	CREBBP EP300	4.23e-06	2	72	2	15706485
Pubmed	AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.	CREBBP EP300	4.23e-06	2	72	2	39266679
Pubmed	A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.	CREBBP EP300	4.23e-06	2	72	2	22303793
Pubmed	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.	CREBBP EP300	4.23e-06	2	72	2	34732714
Pubmed	Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.	CREBBP EP300	4.23e-06	2	72	2	34019788
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALGAPA1 UBR2 SEMA4D ATF6 UXS1 HIVEP2 SH3TC1 RBBP4 STXBP5L OBSCN DIP2C CREBBP EP300	1.04e-05	1489	72	13	28611215
Pubmed	Differential gene expression in the distal tip endoderm of the embryonic mouse lung.	TGFB2 CREBBP GABPB1	1.10e-05	21	72	3	12617806
Pubmed	Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.	CREBBP EP300	1.27e-05	3	72	2	14716005
Pubmed	Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.	RBBP4 CREBBP	1.27e-05	3	72	2	25150575
Pubmed	The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.	CREBBP EP300	1.27e-05	3	72	2	18070920
Pubmed	The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.	CREBBP EP300	1.27e-05	3	72	2	21967847
Pubmed	CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.	CREBBP EP300	1.27e-05	3	72	2	19252086
Pubmed	Excess podocyte semaphorin-3A leads to glomerular disease involving plexinA1-nephrin interaction.	SEMA3A PLXNA1	1.27e-05	3	72	2	23954273
Pubmed	Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.	CREBBP EP300	1.27e-05	3	72	2	27903646
Pubmed	Inhibition of p300/CBP by early B-cell factor.	CREBBP EP300	1.27e-05	3	72	2	12748286
Pubmed	Expression of semaphorin 3A and its receptors during mouse corneal development.	SEMA3A PLXNA1	1.27e-05	3	72	2	21075075
Pubmed	p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.	CREBBP EP300	1.27e-05	3	72	2	10075656
Pubmed	Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.	CREBBP EP300	1.27e-05	3	72	2	24340053
Pubmed	Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.	CREBBP EP300	1.27e-05	3	72	2	19273602
Pubmed	Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.	CREBBP EP300	1.27e-05	3	72	2	15649887
Pubmed	Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development.	CREBBP EP300	1.27e-05	3	72	2	22179676
Pubmed	Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.	SEMA3A PLXNA1	1.27e-05	3	72	2	26602825
Pubmed	CBP/p300 are bimodal regulators of Wnt signaling.	CREBBP EP300	1.27e-05	3	72	2	17410209
Pubmed	DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.	CREBBP EP300	1.27e-05	3	72	2	26951377
Pubmed	CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.	CREBBP EP300	1.27e-05	3	72	2	21789216
Pubmed	Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.	CREBBP EP300	1.27e-05	3	72	2	12050117
Pubmed	Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.	CREBBP EP300	1.27e-05	3	72	2	16237459
Pubmed	A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis.	CREBBP EP300	1.27e-05	3	72	2	12384703
Pubmed	Regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300.	CREBBP EP300	1.27e-05	3	72	2	10350644
Pubmed	Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.	CREBBP EP300	1.27e-05	3	72	2	29145650
Pubmed	Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP.	CREBBP EP300	1.27e-05	3	72	2	7870179
Pubmed	The IFNgamma-induced STAT1-CBP/P300 association, required for a normal response to the cytokine, is disrupted in Brucella-infected macrophages.	CREBBP EP300	1.27e-05	3	72	2	19041714
Interaction	CNTN2 interactions	SEMA3A CNTNAP2 CREBBP EP300	1.20e-06	24	68	4	int:CNTN2
GeneFamily	WD repeat domain containing	WDR3 LLGL1 RBBP4 STXBP5L WDR77 WDFY2	7.25e-05	262	49	6	362
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B RBBP4	2.56e-04	9	49	2	1306
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B RBBP4	4.67e-04	12	49	2	1243
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CREBBP EP300	9.53e-04	17	49	2	486
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CREBBP EP300	1.07e-03	18	49	2	91
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA3A SEMA4D	1.33e-03	20	49	2	736
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	KALRN OBSCN	1.38e-02	66	49	2	722
GeneFamily	Immunoglobulin like domain containing	SEMA3A SEMA4D MMP23B	1.54e-02	193	49	3	594
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122\|Adult / Lineage, Cell type, age group and donor	SEMA3A SIN3B KALRN OBSCN NMUR1	7.95e-06	171	71	5	bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SEMA3A KALRN MMP23B CNTNAP2 PID1	1.46e-05	194	71	5	8c37bedb23285735ff3828db3889897fada8c95d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOCAD HIVEP2 KALRN STXBP5L CADPS2	1.50e-05	195	71	5	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TGFB2 SEMA3A SEMA4D KALRN WDFY2	1.54e-05	196	71	5	b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TGFB2 SEMA3A SEMA4D KALRN WDFY2	1.54e-05	196	71	5	a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOCAD HIVEP2 KALRN STXBP5L CNTNAP2	1.61e-05	198	71	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOCAD HIVEP2 KALRN STXBP5L CNTNAP2	1.61e-05	198	71	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA3A KALRN MMP23B CNTNAP2 PID1	1.61e-05	198	71	5	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FOCAD UBR2 NBAS DIP2C CADPS2	1.65e-05	199	71	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Disease	Menke-Hennekam syndrome	CREBBP EP300	5.39e-06	2	69	2	cv:C5681632
Disease	Rubinstein-Taybi syndrome (implicated_via_orthology)	CREBBP EP300	5.39e-06	2	69	2	DOID:1933 (implicated_via_orthology)
Disease	Rubinstein-Taybi syndrome	CREBBP EP300	5.39e-06	2	69	2	cv:C0035934
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	5.39e-06	2	69	2	C4551859
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	5.39e-06	2	69	2	180849
Disease	Rubinstein-Taybi syndrome due to CREBBP mutations	CREBBP EP300	5.39e-06	2	69	2	cv:C4551859
Disease	Rubinstein-Taybi syndrome (is_implicated_in)	CREBBP EP300	5.39e-06	2	69	2	DOID:1933 (is_implicated_in)
Disease	Rubinstein-Taybi Syndrome	CREBBP EP300	5.39e-06	2	69	2	C0035934
Disease	Small cell carcinoma of lung	CNTNAP2 DIP2C CREBBP EP300	7.93e-06	54	69	4	C0149925
Disease	Adrenal gland hypofunction	CYP11A1 ABCD1	3.22e-05	4	69	2	C0001623
Disease	Malignant neoplasm of breast	PPP1R3A SEMA3A LLGL1 KALRN VPS39 OBSCN NUP133 DIP2C SIM1 RB1CC1 EP300	3.72e-05	1074	69	11	C0006142
Disease	HETE measurement	NBAS APOA5 CNTNAP2	4.19e-04	62	69	3	EFO_0801166
Disease	vital capacity	TGFB2 SEMA3A SEMA4D HIVEP2 GABPB2 PKD1L3 LCT PID1 PLXNA1 GABPB1	5.76e-04	1236	69	10	EFO_0004312
Disease	visceral adipose tissue measurement	PPP1R3A SEMA4D HIVEP2 LLGL1 ABCD1 PKD1L3	9.16e-04	481	69	6	EFO_0004765
Disease	peripheral arterial disease, traffic air pollution measurement	TGFB2 HIVEP2 STXBP5L XAB2	1.12e-03	194	69	4	EFO_0004265, EFO_0007908
Disease	Renal glomerular disease	CREBBP CRB2	1.32e-03	23	69	2	C0268731
Disease	Glomerulopathy Assessment	CREBBP CRB2	1.32e-03	23	69	2	C4521256
Disease	cerebral infarction (is_implicated_in)	KALRN APOA5	2.10e-03	29	69	2	DOID:3526 (is_implicated_in)
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	NUP133 CRB2	2.25e-03	30	69	2	C1868672
Disease	lifestyle measurement	PPP1R3A HIVEP2 SIM1 CRB2	2.26e-03	235	69	4	EFO_0010724

Protein segments in the cluster

Peptide	Gene	Start	Entry
HWIGHENFELINHDV	UXS1	131	Q8NBZ7
WHEDITQDLRNHLVH	EP300	571	Q09472
GWHEHVTQDLRSHLV	CREBBP	591	Q92793
DLWEDITHSLHDQGH	APOA5	346	Q6Q788
HELRGWVHRHEVERT	ATF6	481	P18850
LRQVHLHWGSADDHG	CA13	91	Q8N1Q1
HHVLWVSHVLSQAEG	NPAS1	396	Q99742
LWEIVHHNGCAHLEE	LLGL1	101	Q15334
DVVHLHHILQREGGW	ABCD1	581	P33897
CEGLVHDEHLQHQGW	RB1CC1	136	Q8TDY2
AHEHLSWLHEINSQE	NUP133	931	Q8WUM0
WTDGLHLAFQHVHVI	NMUR1	326	Q9HB89
LHVFNSLEDWHHEAI	NPY4R	281	P50391
DGHWHQVEVVLHLAT	CRB2	516	Q5IJ48
TALHWATEHNHQEVV	GABPB1	106	Q06547
FQVWLHHLDHKGEAT	PID1	141	Q7Z2X4
ADKHQIHDADVRHTW	PLXNA1	1726	Q9UIW2
QEIVVTHWHRDHSGG	LACTB2	71	Q53H82
QWHHLQVEIESLHAV	KRT222	61	Q8N1A0
LTIDTHSHHWERDQQ	MINDY4B	411	A8MYZ0
HSHHWERDQQEEKHG	MINDY4B	416	A8MYZ0
RHAVQHRHRDGVHWD	PCED1A	236	Q9H1Q7
VHEVLHHQRRLESIW	KALRN	511	O60229
IVGHNLIKAHAEAWH	LCT	1566	P09848
LHEAAWHGHSRVAEL	ANKRD65	111	E5RJM6
RHVTRHEHEAWPEDL	NBAS	1611	A2RRP1
HTAVVEDVSWHLLHE	RBBP4	226	Q09028
WEEAVLTPEHHHLTS	PPP1R3A	591	Q16821
WLKDGVELTDGRHHH	OBSCN	4931	Q5VST9
HGLHRILVVDWDVHH	HDAC10	161	Q969S8
ESEHHWDMVRHHLQG	ERVK-24	456	P61566
LGDSHLGEIWVHSAH	DIP2C	1366	Q9Y2E4
LHWPEQEFAHHLEQR	CADPS2	1026	Q86UW7
WRETGTHKVHLHHVQ	CYP11A1	66	P05108
HGRELAAHWAAHTDV	FIZ1	211	Q96SL8
EILRHHVNRNGDVHW	CXorf38	86	Q8TB03
LDDHHWHSVVIERQG	CNTNAP2	271	Q9UHC6
ALVHEVHIQLSEWHR	FOCAD	871	Q5VW36
SLLTTVGWDHQVVHH	WDR77	311	Q9BQA1
AFHGSHIENWHSILR	PARP6	471	Q2NL67
ESIQLHQEAWERHHL	UPF2	126	Q9HAU5
TALHWATERHHRDVV	GABPB2	106	Q8TAK5
DLVESLSNWVHHVQH	RSPH4A	536	Q5TD94
HVHEWHKRVALHQGR	XAB2	356	Q9HCS7
AHEIAWLHGTIQTHQ	NIN	1406	Q8N4C6
WLTDLVHVAAHEIGH	MMP23B	201	O75900
RDTVDILVGWHIDHT	SMG1	316	Q96Q15
GHTWRQVFEEEHHIL	SORCS2	551	Q96PQ0
QGERHWARVVPENHH	PKD1L3	1056	Q7Z443
IASVHRIHGRGHWDE	SIM1	516	P81133
VLLRHHQHFEEWHSR	SIN3B	1091	O75182
DHLVALAWLHVLHGQ	SH3TC1	826	Q8TE82
RLVHAHPHWEEDGEA	WIZ	436	O95785
GHHHPIRTEQHDSRW	SEMA3A	206	Q14563
TWEHREVHLVQFHEP	SEMA4D	31	Q92854
EAIHSIDWHHEGKQF	STXBP5L	251	Q9Y2K9
AVHEWLHHKDRNLGF	TGFB2	206	P61812
RVVIHTSNLIHADWH	TDP1	276	Q9NUW8
VQLWHEEDSGHLHSQ	nan	161	Q6ZTK2
KHNIVHVHFDATRGW	WDFY2	366	Q96P53
LGNDEVHIVWSEHTR	RALGAPA1	1901	Q6GYQ0
VDLQLWTHRDSHVHF	TMEM94	1286	Q12767
WTHRDSHVHFGLEDV	TMEM94	1291	Q12767
WHEHTRPDRDQHVTI	TLL2	251	Q9Y6L7
LHVFNSLEDWHHEAI	NPY4R2	281	P0DQD5
WVINTLADHHHRGTD	NPIPB2	21	A6NJ64
WRSNLTVHHRIHVGD	ZNF226	766	Q9NYT6
EHIQTLEGHHQEIWC	WDR3	666	Q9UNX4
VEEVHELHVWQLAGS	SLC30A1	366	Q9Y6M5
EEEQGHQTWDRHSHE	RPTN	706	Q6XPR3
EQLEHLHAGLRSGWH	HIVEP2	1106	P31629
KLWHQHSVTEEIGHA	UBR2	1726	Q8IWV8
HIIHVWEETGSRFHN	VPS39	606	Q96JC1
SHQALHPWHRDTDLE	LGI3	366	Q8N145
HHVISDEEIIQNWHL	LRRIQ3	156	A6PVS8