Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium channel inhibitor activity

NEDD4L NEDD4

6.08e-058302GO:0019871
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH2 DNAH11

3.29e-0418302GO:0008569
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC20A1 XPR1

5.90e-0424302GO:0005315
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH2 MYH15 DNAH11

7.27e-04118303GO:0003774
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH2 DNAH11

8.05e-0428302GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH2 DNAH11

1.41e-0337302GO:0045505
GeneOntologyMolecularFunctionsodium channel regulator activity

NEDD4L NEDD4

1.98e-0344302GO:0017080
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC24A1 CNGA1 SLC20A1

2.11e-03171303GO:0015081
GeneOntologyMolecularFunctionion channel inhibitor activity

NEDD4L NEDD4

2.36e-0348302GO:0008200
GeneOntologyMolecularFunctionbeta-tubulin binding

ARL8A ARL8B

2.46e-0349302GO:0048487
GeneOntologyMolecularFunctionchannel inhibitor activity

NEDD4L NEDD4

2.56e-0350302GO:0016248
GeneOntologyMolecularFunctiontransporter inhibitor activity

NEDD4L NEDD4

2.66e-0351302GO:0141110
GeneOntologyMolecularFunctionalpha-tubulin binding

ARL8A ARL8B

2.76e-0352302GO:0043014
GeneOntologyMolecularFunctionactin filament binding

MYH15 MICALL2 SPTB

4.69e-03227303GO:0051015
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

NIPAL3 SLC24A1 CNGA1 SLC20A1

4.92e-03465304GO:0046873
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH2 DNAH11

4.95e-0370302GO:0003777
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

NIPAL3 SLC24A1 CNGA1 SLC20A1 XPR1

5.04e-03758305GO:0015318
GeneOntologyMolecularFunctioncytoskeletal protein binding

MYH15 ARL8A DMD MICALL2 ARL8B SPTB

5.21e-031099306GO:0008092
GeneOntologyMolecularFunctionactin binding

MYH15 DMD MICALL2 SPTB

5.47e-03479304GO:0003779
GeneOntologyBiologicalProcesssodium ion transmembrane transport

DMD NEDD4L SLC24A1 CNGA1 SLC20A1 NEDD4

4.75e-07208306GO:0035725
GeneOntologyBiologicalProcesssodium ion transport

DMD NEDD4L SLC24A1 CNGA1 SLC20A1 NEDD4

2.41e-06275306GO:0006814
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

DMD NEDD4L NIPAL3 SLC24A1 CNGA1 SLC20A1 XPR1 NEDD4

7.53e-051017308GO:0098660
GeneOntologyBiologicalProcessregulation of sodium ion transmembrane transporter activity

DMD NEDD4L NEDD4

7.70e-0557303GO:2000649
GeneOntologyBiologicalProcessregulation protein catabolic process at postsynapse

NEDD4L NEDD4

9.14e-0510302GO:0140252
GeneOntologyBiologicalProcessregulation of sodium ion transmembrane transport

DMD NEDD4L NEDD4

1.36e-0469303GO:1902305
GeneOntologyBiologicalProcessregulation protein catabolic process at synapse

NEDD4L NEDD4

1.84e-0414302GO:0140250
GeneOntologyBiologicalProcessphosphate ion transmembrane transport

SLC20A1 XPR1

2.12e-0415302GO:0035435
GeneOntologyBiologicalProcessnegative regulation of sodium ion transmembrane transporter activity

NEDD4L NEDD4

2.42e-0416302GO:2000650
GeneOntologyBiologicalProcessnegative regulation of sodium ion transmembrane transport

NEDD4L NEDD4

2.74e-0417302GO:1902306
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

DMD NEDD4L NIPAL3 SLC24A1 CNGA1 SLC20A1 NEDD4

2.88e-04922307GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

DMD NEDD4L NIPAL3 SLC24A1 CNGA1 SLC20A1 NEDD4

3.28e-04942307GO:0098655
GeneOntologyBiologicalProcessregulation of sodium ion transport

DMD NEDD4L NEDD4

4.20e-04101303GO:0002028
GeneOntologyBiologicalProcesslymphocyte mediated immunity

IGHV3-53 ARL8B CLCF1 STAT5B IGHV3-64D

4.35e-04449305GO:0002449
GeneOntologyBiologicalProcessregulation of dendrite morphogenesis

CUL7 NEDD4L NEDD4

4.45e-04103303GO:0048814
GeneOntologyBiologicalProcessnegative regulation of sodium ion transport

NEDD4L NEDD4

4.64e-0422302GO:0010766
GeneOntologyBiologicalProcessmetal ion transport

DMD NEDD4L NIPAL3 SLC24A1 CNGA1 SLC20A1 NEDD4

4.70e-041000307GO:0030001
GeneOntologyBiologicalProcessaxoneme assembly

DNAH2 TBC1D32 DRC1

5.25e-04109303GO:0035082
GeneOntologyBiologicalProcessmicrotubule-based process

DNAH2 TBC1D32 DRC1 ARL8A CUL7 ARL8B DNAH11

6.59e-041058307GO:0007017
GeneOntologyBiologicalProcessmicrotubule-based movement

DNAH2 DRC1 ARL8A ARL8B DNAH11

6.65e-04493305GO:0007018
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

DMD NEDD4L NIPAL3 SLC24A1 CNGA1 SLC20A1 NEDD4

9.00e-041115307GO:0034220
GeneOntologyBiologicalProcessphosphate ion transport

SLC20A1 XPR1

9.26e-0431302GO:0006817
GeneOntologyBiologicalProcessmonoatomic cation transport

DMD NEDD4L NIPAL3 SLC24A1 CNGA1 SLC20A1 NEDD4

1.12e-031157307GO:0006812
GeneOntologyBiologicalProcessmicrotubule bundle formation

DNAH2 TBC1D32 DRC1

1.20e-03145303GO:0001578
GeneOntologyBiologicalProcessregulation of dendrite development

CUL7 NEDD4L NEDD4

1.33e-03150303GO:0050773
GeneOntologyBiologicalProcessleukocyte mediated immunity

IGHV3-53 ARL8B CLCF1 STAT5B IGHV3-64D

1.33e-03576305GO:0002443
GeneOntologyBiologicalProcessdetermination of left/right symmetry

TBC1D32 DRC1 DNAH11

1.43e-03154303GO:0007368
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor internalization

NEDD4L NEDD4

1.47e-0339302GO:0099149
GeneOntologyCellularComponentdynein complex

DNAH2 DRC1 DNAH11

6.30e-0554303GO:0030286
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

DNAH2 DRC1 ARL8A ARL8B DNAH11

8.11e-05317305GO:0032838
GeneOntologyCellularComponentcytoplasmic region

DNAH2 DRC1 ARL8A ARL8B DNAH11

1.47e-04360305GO:0099568
GeneOntologyCellularComponentaxonemal dynein complex

DNAH2 DRC1

5.85e-0425302GO:0005858
GeneOntologyCellularComponentspindle midzone

ARL8A ARL8B

1.50e-0340302GO:0051233
GeneOntologyCellularComponentmicrotubule associated complex

DNAH2 DRC1 DNAH11

1.56e-03161303GO:0005875
MousePhenoleft pulmonary isomerism

TBC1D32 DRC1 DNAH11

1.48e-0531223MP:0003178
MousePhenodual inferior vena cava

TBC1D32 DRC1 DNAH11

1.96e-0534223MP:0011683
MousePhenoleft-sided isomerism

TBC1D32 DRC1 DNAH11

1.96e-0534223MP:0000542
MousePhenositus inversus with levocardia

DRC1 DNAH11

4.94e-057222MP:0011253
MousePhenoabnormal right lung morphology

TBC1D32 DRC1 DNAH11

5.25e-0547223MP:0009570
MousePhenotransposition of great arteries

TBC1D32 DRC1 DNAH11

5.25e-0547223MP:0004110
MousePhenoleft atrial isomerism

TBC1D32 DNAH11

6.58e-058222MP:0008461
MousePhenoabdominal situs inversus

DRC1 DNAH11

8.46e-059222MP:0011249
MousePhenoabnormal lung position or orientation

TBC1D32 DRC1 DNAH11

9.37e-0557223MP:0010853
MousePhenoschistocytosis

SLC20A1 SPTB

1.06e-0410222MP:0000314
MousePhenopulmonary artery hypoplasia

TBC1D32 DNAH11

1.29e-0411222MP:0010460
MousePhenoabnormal inferior vena cava morphology

TBC1D32 DRC1 DNAH11

1.59e-0468223MP:0006063
MousePhenoabnormal a-wave shape

CYP4V2 SLC24A1 CNGA1

1.73e-0470223MP:0012034
MousePhenoright atrial isomerism

TBC1D32 DNAH11

1.82e-0413222MP:0006061
MousePhenospherocytosis

SLC20A1 SPTB

1.82e-0413222MP:0002812
MousePhenoabnormal heart position or orientation

TBC1D32 DRC1 DNAH11

2.04e-0474223MP:0006065
MousePhenoabnormal sperm flagellum thickness

DNAH2 DRC1

2.13e-0414222MP:0031351
MousePhenoabnormal vena cava morphology

TBC1D32 DRC1 DNAH11

2.29e-0477223MP:0006062
MousePhenoabnormal retina cone cell morphology

CYP4V2 SLC24A1 CNGA1

2.29e-0477223MP:0001006
MousePhenoabnormal retina rod cell morphology

CYP4V2 SLC24A1 CNGA1

2.38e-0478223MP:0001005
MousePhenoabdominal situs ambiguus

DRC1 DNAH11

2.80e-0416222MP:0011250
MousePhenoabnormal heart atrium arrangement

TBC1D32 DNAH11

3.17e-0417222MP:0014319
MousePhenoabnormal retina cone cell outer segment morphology

CYP4V2 SLC24A1

3.56e-0418222MP:0008449
MousePhenoheterotaxia

TBC1D32 DRC1 DNAH11

3.64e-0490223MP:0004133
MousePhenopale liver

FLI1 SLC20A1 STAT5B

3.88e-0492223MP:0000603
MousePhenoduplex kidney

TBC1D32 DNAH11

3.98e-0419222MP:0004017
MousePhenoabnormal heart atrium morphology

TBC1D32 DRC1 DMD DNAH11

4.27e-04232224MP:0003105
MousePhenomesocardia

TBC1D32 DNAH11

4.42e-0420222MP:0000650
MousePhenoabdominal situs abnormality

DRC1 DNAH11

4.88e-0421222MP:0031284
MousePhenoincreased growth hormone level

DMD STAT5B

5.86e-0423222MP:0005137
MousePhenositus inversus totalis

DRC1 DNAH11

5.86e-0423222MP:0011252
MousePhenoabnormal electroretinogram waveform feature

CYP4V2 SLC24A1 CNGA1

5.88e-04106223MP:0012029
MousePhenohydronephrosis

NEDD4L SPTB DNAH11

6.38e-04109223MP:0000519
MousePhenodecreased leukocyte cell number

FLI1 MYH15 IL1RL1 NIPAL3 CLCF1 PARG STAT5B NEDD4

6.60e-041342228MP:0000221
MousePhenoretina photoreceptor degeneration

CYP4V2 SLC24A1 CNGA1

6.72e-04111223MP:0008450
MousePhenoabnormal aortic arch morphology

TBC1D32 DRC1 DNAH11

8.23e-04119223MP:0004113
MousePhenoabnormal kidney pelvis morphology

NEDD4L SPTB DNAH11

9.27e-04124223MP:0004194
MousePhenoabnormal respiratory motile cilium physiology

DRC1 DNAH11

9.36e-0429222MP:0011055
MousePhenoblindness

SLC24A1 CNGA1

1.00e-0330222MP:0002001
MousePhenoright-sided isomerism

TBC1D32 DNAH11

1.00e-0330222MP:0000508
MousePhenoretina rod cell degeneration

SLC24A1 CNGA1

1.07e-0331222MP:0008451
MousePhenoright-sided stomach

TBC1D32 DNAH11

1.07e-0331222MP:0010808
MousePhenopoikilocytosis

SLC20A1 SPTB

1.07e-0331222MP:0002643
MousePhenoabnormal thoracic aorta morphology

TBC1D32 DRC1 DNAH11

1.16e-03134223MP:0010468
MousePhenodecreased immunoglobulin level

FLI1 IL1RL1 NIPAL3 NEDD4

1.34e-03315224MP:0002460
MousePhenoabnormal photoreceptor outer segment morphology

CYP4V2 SLC24A1 CNGA1

1.34e-03141223MP:0003729
MousePhenovascular ring

TBC1D32 DNAH11

1.36e-0335222MP:0010466
MousePhenoabnormal stomach position or orientation

TBC1D32 DNAH11

1.44e-0336222MP:0010807
MousePhenohemolytic anemia

SLC20A1 SPTB

1.44e-0336222MP:0001585
MousePhenoabnormal liver size

CYP4V2 FLI1 SLC20A1 SPTB STAT5B

1.54e-03562225MP:0004848
MousePhenointerrupted aortic arch

DRC1 DNAH11

1.87e-0341222MP:0004157
MousePhenointerrupted aorta

DRC1 DNAH11

2.05e-0343222MP:0010544
MousePhenoincreased variability of skeletal muscle fiber size

DMD NEDD4

2.05e-0343222MP:0009403
DomainWW

DMD NEDD4L NEDD4

4.68e-0547283PF00397
DomainWW

DMD NEDD4L NEDD4

4.99e-0548283SM00456
DomainWW_DOMAIN_2

DMD NEDD4L NEDD4

5.99e-0551283PS50020
DomainWW_DOMAIN_1

DMD NEDD4L NEDD4

5.99e-0551283PS01159
DomainDynein_heavy_dom-1

DNAH2 DNAH11

6.03e-058282IPR013594
DomainDHC_N1

DNAH2 DNAH11

6.03e-058282PF08385
DomainWW_dom

DMD NEDD4L NEDD4

6.35e-0552283IPR001202
DomainCH

DMD MICALL2 SPTB

1.24e-0465283SM00033
DomainCH

DMD MICALL2 SPTB

1.54e-0470283PF00307
Domain-

DMD MICALL2 SPTB

1.61e-04712831.10.418.10
DomainCH

DMD MICALL2 SPTB

1.75e-0473283PS50021
DomainCH-domain

DMD MICALL2 SPTB

1.90e-0475283IPR001715
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH11

1.95e-0414282IPR011704
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH11

1.95e-0414282IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH11

1.95e-0414282IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH11

1.95e-0414282IPR013602
DomainDHC_N2

DNAH2 DNAH11

1.95e-0414282PF08393
DomainMT

DNAH2 DNAH11

1.95e-0414282PF12777
DomainAAA_8

DNAH2 DNAH11

1.95e-0414282PF12780
DomainAAA_5

DNAH2 DNAH11

1.95e-0414282PF07728
DomainDHC_fam

DNAH2 DNAH11

2.25e-0415282IPR026983
DomainDynein_heavy_dom

DNAH2 DNAH11

2.25e-0415282IPR004273
DomainDynein_heavy

DNAH2 DNAH11

2.25e-0415282PF03028
DomainActinin_actin-bd_CS

DMD SPTB

5.38e-0423282IPR001589
DomainACTININ_2

DMD SPTB

5.38e-0423282PS00020
DomainACTININ_1

DMD SPTB

5.38e-0423282PS00019
DomainSpectrin

DMD SPTB

5.38e-0423282PF00435
DomainHECT

NEDD4L NEDD4

7.43e-0427282PF00632
DomainHECTc

NEDD4L NEDD4

7.43e-0427282SM00119
DomainHECT_dom

NEDD4L NEDD4

7.43e-0427282IPR000569
DomainHECT

NEDD4L NEDD4

7.43e-0427282PS50237
DomainARF

ARL8A ARL8B

8.58e-0429282PS51417
DomainSmall_GTPase_ARF

ARL8A ARL8B

8.58e-0429282IPR024156
DomainSpectrin_repeat

DMD SPTB

8.58e-0429282IPR002017
DomainArf

ARL8A ARL8B

9.81e-0431282PF00025
DomainSpectrin/alpha-actinin

DMD SPTB

1.05e-0332282IPR018159
DomainSPEC

DMD SPTB

1.05e-0332282SM00150
DomainSmall_GTPase_ARF/SAR

ARL8A ARL8B

1.11e-0333282IPR006689
DomainP-loop_NTPase

DNAH2 MYH15 ARL8A ARL8B DNAH11

7.85e-03848285IPR027417
Pubmed

Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein.

ARL8A ARL8B

7.19e-07230214871887
Pubmed

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

NEDD4L NEDD4

7.19e-07230211502596
Pubmed

An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility.

ARL8A ARL8B

7.19e-07230216537643
Pubmed

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

ARL8A ARL8B

7.19e-07230230174114
Pubmed

Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

NEDD4L NEDD4

7.19e-07230223262292
Pubmed

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

NEDD4L NEDD4

7.19e-07230237962894
Pubmed

Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

7.19e-07230219602703
Pubmed

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

NEDD4L NEDD4

7.19e-07230211149908
Pubmed

Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs.

SLC24A1 CNGA1

7.19e-07230212693957
Pubmed

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.

NEDD4L NEDD4

7.19e-07230231802037
Pubmed

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

NEDD4L NEDD4

2.16e-06330211779188
Pubmed

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

NEDD4L NEDD4

2.16e-06330218498246
Pubmed

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

NEDD4L NEDD4

2.16e-06330221852580
Pubmed

Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles.

DMD SPTB

2.16e-06330210867799
Pubmed

The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

2.16e-06330222361880
Pubmed

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

NEDD4L NEDD4

2.16e-06330215217910
Pubmed

Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.

NEDD4L NEDD4

2.16e-06330212729930
Pubmed

Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.

NEDD4L NEDD4

2.16e-06330219423771
Pubmed

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

NEDD4L NEDD4

2.16e-06330212050153
Pubmed

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

NEDD4L NEDD4

2.16e-06330220730100
Pubmed

Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1.

NEDD4L NEDD4

2.16e-06330226823285
Pubmed

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.

NEDD4L NEDD4

2.16e-06330223686771
Pubmed

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

NEDD4L NEDD4

2.16e-06330215677482
Pubmed

The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.

NEDD4L NEDD4

4.31e-06430227466427
Pubmed

SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.

NEDD4L NEDD4

4.31e-06430228608480
Pubmed

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.

NEDD4L NEDD4

4.31e-06430217544362
Pubmed

Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.

ARL8A ARL8B

4.31e-06430215331635
Pubmed

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

NEDD4L NEDD4

4.31e-06430220026598
Pubmed

C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.

NEDD4L NEDD4

4.31e-06430231357244
Pubmed

Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.

NEDD4L NEDD4

4.31e-06430229897283
Pubmed

NEDD4-2 associates with gamma(c) and regulates its degradation rate.

NEDD4L NEDD4

4.31e-06430219615332
Pubmed

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

NEDD4L NEDD4

4.31e-06430222024150
Pubmed

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

NEDD4L NEDD4

4.31e-06430211696533
Pubmed

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.

NEDD4L NEDD4

4.31e-06430221463633
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

CUL7 DMD NEDD4L SLC20A1 NEDD4

6.77e-0631330538270169
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

NEDD4L NEDD4

7.18e-06530215548568
Pubmed

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

NEDD4L NEDD4

7.18e-06530225157163
Pubmed

Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

NEDD4L NEDD4

7.18e-06530230287686
Pubmed

An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.

NEDD4L NEDD4

7.18e-06530218687683
Pubmed

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.

NEDD4L NEDD4

7.18e-06530227793840
Pubmed

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

NEDD4L NEDD4

7.18e-06530222385262
Pubmed

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

NEDD4L NEDD4

7.18e-06530221478478
Pubmed

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.

NEDD4L NEDD4

7.18e-06530231867777
Pubmed

A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline.

NEDD4L NEDD4

7.18e-06530236002265
Pubmed

The ESCRT pathway and HIV-1 budding.

NEDD4L NEDD4

7.18e-06530219143627
Pubmed

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.

NEDD4L NEDD4

7.18e-06530219706893
Pubmed

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.

NEDD4L NEDD4

7.18e-06530219617352
Pubmed

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

NEDD4L NEDD4

7.18e-06530225631046
Pubmed

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.

NEDD4L NEDD4

7.18e-06530218577513
Pubmed

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

NEDD4L NEDD4

7.18e-06530217289006
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

NEDD4L NEDD4

1.08e-05630215252135
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

NEDD4L NEDD4

1.08e-05630237156795
Pubmed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

NEDD4L NEDD4

1.08e-05630227445338
Pubmed

Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.

NEDD4L NEDD4

1.08e-05630216701206
Pubmed

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

NEDD4L NEDD4

1.08e-05630226854353
Pubmed

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

NEDD4L NEDD4

1.08e-05630229964046
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

NEDD4L NEDD4

1.08e-05630211748237
Pubmed

Stat5 expression is critical for mast cell development and survival.

IL1RL1 STAT5B

1.08e-05630212714518
Pubmed

Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.

DMD BRI3BP NEDD4

1.47e-055530331985874
Pubmed

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

NEDD4L NEDD4

1.51e-05730230587574
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

NEDD4L NEDD4

1.51e-05730211046148
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

NEDD4L NEDD4

1.51e-05730223644597
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

NEDD4L NEDD4

1.51e-05730220051513
Pubmed

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

NEDD4L NEDD4

1.51e-05730220086093
Pubmed

Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.

TBC1D32 DMD

1.51e-05730212176734
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH2 DNAH11

1.51e-05730231178125
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

NEDD4L NEDD4

1.51e-05730224831002
Pubmed

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

NEDD4L NEDD4

1.51e-05730216337426
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH2 DNAH11

1.51e-0573029256245
Pubmed

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

ARL8A NEDD4L BRI3BP ARL8B NEDD4

2.00e-0539230533144569
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

NEDD4L NEDD4

2.01e-05830211244092
Pubmed

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.

NEDD4L NEDD4

2.01e-05830224036464
Pubmed

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

NEDD4L NEDD4

2.01e-05830217719543
Pubmed

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

2.58e-05930218981174
Pubmed

Expression of Phosphate Transporters during Dental Mineralization.

SLC20A1 XPR1

2.58e-05930228892649
Pubmed

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

NEDD4L NEDD4

2.58e-05930215496141
Pubmed

Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions.

DMD SPTB

3.22e-051030214627610
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

NEDD4L NEDD4

3.22e-051030225092867
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

NEDD4L NEDD4

3.94e-051130222773947
Pubmed

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.

NEDD4L NEDD4

3.94e-051130221505443
Pubmed

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

NEDD4L NEDD4

3.94e-051130225963657
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

NEDD4L NEDD4

5.58e-051330215123669
Pubmed

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

ARL8A ARL8B

5.58e-051330228325809
Pubmed

BORC, a multisubunit complex that regulates lysosome positioning.

ARL8A ARL8B

5.58e-051330225898167
Pubmed

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

NEDD4L NEDD4

5.58e-051330223146885
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH2 DNAH11

6.50e-05143029373155
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

NEDD4L NEDD4

7.50e-051530223236378
Pubmed

1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.

IGHV3-53 IGHV3-64D

7.50e-051530212657787
Pubmed

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

NEDD4L NEDD4

8.57e-051630221920314
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

TBC1D32 DRC1 DNAH11

8.85e-0510030325807483
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

NEDD4L NEDD4

9.70e-051730228292929
Pubmed

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.

IL1RL1 STAT5B

9.70e-051730219666510
Pubmed

Wrapping up the bad news: HIV assembly and release.

NEDD4L NEDD4

1.09e-041830223305486
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

NEDD4L NEDD4

1.22e-041930221572392
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

NEDD4L NEDD4

1.50e-042130237005481
Pubmed

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

NEDD4L NEDD4

1.50e-042130229416926
Pubmed

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

IGHV3-53 IGHV3-64D

1.64e-04223022499654
Pubmed

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

DRC1 DNAH11

2.13e-042530227340223
Pubmed

Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

NEDD4L NEDD4

2.13e-042530223873930
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

NEDD4L NEDD4

2.31e-042630226949039
InteractionRNF11 interactions

DMD NEDD4L BRI3BP SLC20A1 NEDD4

3.94e-06169295int:RNF11
InteractionSLC24A1 interactions

SLC24A1 CNGA1

1.20e-054292int:SLC24A1
InteractionPRRG3 interactions

NEDD4L NEDD4

1.99e-055292int:PRRG3
InteractionMARK2 interactions

ARL8A DMD NEDD4L ARL8B NEDD4

4.07e-05274295int:MARK2
InteractionCYYR1 interactions

NEDD4L NEDD4

5.57e-058292int:CYYR1
InteractionMS4A10 interactions

NEDD4L NEDD4

8.93e-0510292int:MS4A10
InteractionPRRG2 interactions

NEDD4L NEDD4

8.93e-0510292int:PRRG2
InteractionERMN interactions

CUL7 NEDD4

8.93e-0510292int:ERMN
InteractionTMEM252 interactions

NEDD4L NEDD4

1.09e-0411292int:TMEM252
InteractionILDR1 interactions

NEDD4L NEDD4

1.09e-0411292int:ILDR1
InteractionSCN10A interactions

NEDD4L NEDD4

1.09e-0411292int:SCN10A
InteractionCAV3 interactions

CUL7 DMD NEDD4L

1.43e-0471293int:CAV3
InteractionNPC1 interactions

ARL8A NEDD4L BRI3BP ARL8B NEDD4

1.55e-04364295int:NPC1
InteractionTMEM171 interactions

NEDD4L SLC20A1 NEDD4

1.75e-0476293int:TMEM171
InteractionMOB3A interactions

NEDD4L NEDD4

1.80e-0414292int:MOB3A
InteractionLITAF interactions

ARL8A NEDD4L NEDD4

1.82e-0477293int:LITAF
InteractionPRRG1 interactions

NEDD4L NEDD4

2.08e-0415292int:PRRG1
InteractionMAP3K3 interactions

CUL7 NEDD4L NEDD4

2.36e-0484293int:MAP3K3
InteractionPLEKHM2 interactions

ARL8A ARL8B

2.37e-0416292int:PLEKHM2
InteractionPRR16 interactions

NEDD4L NEDD4

2.37e-0416292int:PRR16
InteractionSCN3A interactions

NEDD4L NEDD4

2.37e-0416292int:SCN3A
InteractionSUSD6 interactions

NEDD4L NEDD4

2.37e-0416292int:SUSD6
InteractionTMEM255A interactions

NEDD4L NEDD4

2.68e-0417292int:TMEM255A
InteractionCNGA1 interactions

SLC24A1 CNGA1

2.68e-0417292int:CNGA1
InteractionTMEM92 interactions

NEDD4L NEDD4

2.68e-0417292int:TMEM92
InteractionARRDC3 interactions

CUL7 DMD NEDD4L NEDD4

2.84e-04224294int:ARRDC3
InteractionTMEM174 interactions

NEDD4L NEDD4

3.02e-0418292int:TMEM174
InteractionRASL11B interactions

NEDD4L NEDD4

3.37e-0419292int:RASL11B
InteractionSCN2A interactions

NEDD4L NEDD4

3.37e-0419292int:SCN2A
InteractionCLIC2 interactions

NEDD4L NEDD4

3.74e-0420292int:CLIC2
InteractionSCN8A interactions

NEDD4L NEDD4

3.74e-0420292int:SCN8A
InteractionKCNQ1 interactions

NEDD4L NEDD4

4.13e-0421292int:KCNQ1
InteractionSCN9A interactions

NEDD4L NEDD4

4.13e-0421292int:SCN9A
InteractionARPC1A interactions

ARL8A CUL7 ARL8B

4.18e-04102293int:ARPC1A
InteractionSLC22A8 interactions

NEDD4L NEDD4

4.54e-0422292int:SLC22A8
InteractionLONRF3 interactions

CUL7 DMD

4.54e-0422292int:LONRF3
InteractionSCNN1G interactions

NEDD4L NEDD4

4.54e-0422292int:SCNN1G
InteractionNDFIP1 interactions

NEDD4L SLC20A1 NEDD4

4.55e-04105293int:NDFIP1
InteractionKCNAB1 interactions

NEDD4L NEDD4

5.88e-0425292int:KCNAB1
InteractionDNAH17 interactions

DNAH2 DNAH11

6.36e-0426292int:DNAH17
InteractionOCLN interactions

ARL8A NEDD4L ARL8B XPR1 NEDD4

6.69e-04500295int:OCLN
InteractionSLC22A6 interactions

NEDD4L NEDD4

7.38e-0428292int:SLC22A6
InteractionSCNN1B interactions

NEDD4L NEDD4

7.38e-0428292int:SCNN1B
InteractionFBXL15 interactions

NEDD4L NEDD4

7.92e-0429292int:FBXL15
InteractionSCN1A interactions

NEDD4L NEDD4

7.92e-0429292int:SCN1A
InteractionSTAC interactions

NEDD4L STAT5B

8.48e-0430292int:STAC
InteractionCDKN2AIPNL interactions

CUL7 SPTB

9.06e-0431292int:CDKN2AIPNL
GeneFamilyDyneins, axonemal

DNAH2 DNAH11

1.90e-0417222536
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

ARL8A ARL8B

6.43e-0431222357
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH2 DRC1 DMD DNAH11

8.24e-06193304ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMD NEDD4L CLCF1 NEDD4

8.94e-061973045bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 IL1RL1 SPTB

1.33e-041483031668d8a9e680da335362744f36b05446c499347e
ToppCell356C-Myeloid-Mast_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 IL1RL1 SPTB

1.33e-0414830318511ba10765eda937c5a710626361f7e6b9b321
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

DRC1 NEDD4L DNAH11

1.41e-041513038216462e723fec2797387929dde095370947e10a
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

FLI1 SLC24A1 MICALL2

1.76e-04163303d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 IL1RL1 SPTB

1.80e-04164303b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 IL1RL1 SPTB

1.80e-04164303f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCellwk_20-22-Hematologic-Myeloid-GMP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BRI3BP SLC24A1 MICALL2

1.86e-04166303d96e88e73a40205f32cebd7e54ca1ff09ee1e7e8
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL1RL1 BRI3BP SLC20A1

1.93e-04168303cc0dd43d5cda01e643d8e8d74ec7617d61890760
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

FLI1 CLCF1 NEDD4

2.03e-04171303bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCellCOVID-19-kidney-Plasma|kidney / Disease (COVID-19 only), tissue and cell type

IGHV3-53 FLI1 IGHV3-64D

2.03e-04171303a59a054b8e119215f24dc5c80ad5a8094b3500f9
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IGHV3-53 MYH15 IGHV3-64D

2.03e-04171303c2b7bbabc8f9afa8a1157b567d5f962d4b242919
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ARL8B PARG NEDD4

2.10e-04173303b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL1RL1 MICALL2 NEDD4

2.10e-04173303117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 DRC1 DNAH11

2.10e-04173303c3762655caa79ac4879876f470d32578a3c93b01
ToppCell368C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TBC1D32 IL1RL1 SPTB

2.10e-041733038cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell368C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TBC1D32 IL1RL1 SPTB

2.10e-04173303fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL1RL1 MICALL2 NEDD4

2.10e-0417330301df9baeedf30e3a4891738554cdd300394dbb96
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ADA2 CLCF1 XPR1

2.14e-04174303a1f745962a104c6f4b86b7e482da8755384c773a
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL1RL1 CNGA1 NEDD4

2.14e-04174303009e88a6c79689a5d88b0af50aa89aa03b33f800
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL1RL1 CNGA1 NEDD4

2.14e-04174303e9e4532a474b4b0938a50ff85c9508aca53cd3ae
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ADA2 CLCF1 XPR1

2.17e-0417530378a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMD PARG NEDD4

2.21e-04176303749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL1RL1 CNGA1 NEDD4

2.21e-041763038e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL1RL1 BRI3BP NEDD4

2.25e-041773039b4c1ca5c6fca9a7a936dad49a04155903ef9c32
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL1RL1 CNGA1 NEDD4

2.36e-0418030341e8155cc7b3dac9d496e4077845ca6af1591a5c
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

IL1RL1 NEDD4L NEDD4

2.40e-04181303c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DNAH2 IL1RL1 SPTB

2.40e-04181303c35ca98c474e31917e0a53c092397e0d8d18b37c
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.44e-041823037ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH2 DRC1 DNAH11

2.44e-04182303fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH15 DMD DNAH11

2.52e-04184303ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH15 DMD DNAH11

2.52e-041843032cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH15 DMD DNAH11

2.52e-041843032b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.52e-041843035daff849625f2f41d56615569c0ed59cd733b34c
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.56e-0418530330f4980dee6cd5959655f8d74049f3bfb5312611
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC1 DMD DNAH11

2.56e-041853034e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.56e-041853033e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH2 DRC1 DNAH11

2.56e-0418530318a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 DRC1 DNAH11

2.56e-041853035e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.56e-041853030998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC1 DMD DNAH11

2.60e-0418630316092819e9148dfe64f07c737652b6e533e699f7
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 DRC1 DNAH11

2.60e-0418630376033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 DRC1 DNAH11

2.60e-0418630385787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.64e-041873039e10ed56090d82589bc457788282f664b70ace4b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.68e-0418830334b11f72ca73153d02edcd09b38983ad1a504659
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.68e-0418830361a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.68e-041883032b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.68e-04188303803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

DNAH2 DRC1 DNAH11

2.72e-04189303a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.72e-0418930368a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.72e-04189303a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

DNAH2 DRC1 DNAH11

2.72e-04189303b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

DNAH2 DRC1 DNAH11

2.72e-0418930327329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.72e-041893033e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.72e-0418930393b1026bb1ba759e5704561c9a5de14a30c08894
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)|343B / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 DRC1 DNAH11

2.77e-04190303169e600e95878000acf5d11f813f9028c7249646
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)-|343B / Donor, Lineage, Cell class and subclass (all cells)

DNAH2 DRC1 DNAH11

2.77e-041903030cc36117c793d83cf4a1f66f47758a07d6712bd3
ToppCellcellseq2-Epithelial-Epithelial_Airway|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.77e-0419030317829f4de31b3d9e4d71ba4817d18842aa699773
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 DRC1 DNAH11

2.81e-04191303df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 DRC1 DNAH11

2.81e-041913037b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH2 DRC1 DNAH11

2.81e-041913032a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 DRC1 DNAH11

2.81e-041913032d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.81e-04191303e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 DRC1 DNAH11

2.81e-0419130346c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 DRC1 DNAH11

2.81e-041913039f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 DRC1 DNAH11

2.81e-04191303fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellControl-Epithelial|Control / Disease group,lineage and cell class (2021.01.30)

DNAH2 DRC1 DNAH11

2.81e-04191303b78547dae8328244a47c83346447bdd787efbcae
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.81e-04191303ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.81e-041913039d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH2 DRC1 DNAH11

2.81e-04191303b4e335e798c9617356b8e24412f9270c42dce656
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH2 DRC1 DNAH11

2.81e-04191303e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 DRC1 DNAH11

2.81e-04191303c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH2 DRC1 DNAH11

2.81e-04191303995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 DRC1 DNAH11

2.81e-04191303c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 DRC1 DNAH11

2.81e-041913035129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 DRC1 DNAH11

2.81e-04191303a37f20172b85566b9039254a89680e37fd503fd5
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class (2021.01.30)

DNAH2 DRC1 DNAH11

2.81e-04191303cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.81e-041913036228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.81e-041913031c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellnormal_Lung-Epithelial_cells-Ciliated|normal_Lung / Location, Cell class and cell subclass

DNAH2 DRC1 DNAH11

2.85e-04192303097a13121820ab4e5cd2365600efccf5ea4ce8c3
ToppCellLAM-Epithelial-AirwayEpi|LAM / Condition, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.85e-041923037404fc65be3b7bd09447725b43fa31819004dfee
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.85e-04192303354adc1354bf596fbc60dd45c0169688e6f45165
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLI1 IL1RL1 NEDD4

2.90e-04193303f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.90e-041933030e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DRC1 NEDD4L DNAH11

2.90e-04193303bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 NEDD4L NEDD4

2.90e-04193303aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell15-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.90e-04193303aa3acc7571405169efb656d214f3a8cbf988362e
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 NEDD4L NEDD4

2.90e-04193303c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 NEDD4L NEDD4

2.90e-04193303e1d546165dcc2392f540162206852c4717d7306f
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH2 DRC1 DNAH11

2.94e-04194303756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellwk_15-18-Epithelial-Proximal_epithelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH2 DRC1 DNAH11

2.94e-04194303b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

DNAH2 DRC1 DNAH11

2.94e-0419430343be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 DRC1 DNAH11

2.99e-04195303d8bf15aa7cdbc5f29b58e1e6cff76c257f0ea12e
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 DRC1 DNAH11

2.99e-04195303649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 DRC1 DNAH11

2.99e-04195303129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 DRC1 DNAH11

2.99e-041953033e70ee987d66d450062d5df3d7c733ccc7344470
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH2 DRC1 DNAH11

2.99e-041953033486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH2 DRC1 DNAH11

2.99e-04195303e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH2 DRC1 DNAH11

2.99e-04195303cfcf554b436083179dea1d6fd6e3a800ea2430fe
DrugNifurtimox [23256-30-6]; Up 200; 14uM; HL60; HT_HG-U133A

DMD NEDD4L SLC24A1 CLCF1 SPTB

3.85e-061972852908_UP
DiseaseLiddle syndrome (implicated_via_orthology)

NEDD4L NEDD4

5.99e-064302DOID:0050477 (implicated_via_orthology)
Diseasevisceral heterotaxy (implicated_via_orthology)

TBC1D32 DRC1 DNAH11

7.20e-0637303DOID:0050545 (implicated_via_orthology)
DiseaseKartagener syndrome (implicated_via_orthology)

DRC1 DNAH11

9.02e-0514302DOID:0050144 (implicated_via_orthology)
Diseasemuscular atrophy (biomarker_via_orthology)

DMD NEDD4

3.99e-0429302DOID:767 (biomarker_via_orthology)
DiseasePrimary ciliary dyskinesia

DRC1 DNAH11

6.16e-0436302cv:C0008780
DiseaseCombined immunodeficiency

ADA2 STAT5B

7.99e-0441302C0494261
DiseaseMicrocalcification

DMD XPR1

8.39e-0442302C0521174
DiseaseCalcinosis

DMD XPR1

8.39e-0442302C0006663
DiseaseTumoral calcinosis

DMD XPR1

8.39e-0442302C0263628

Protein segments in the cluster

PeptideGeneStartEntry
MFVETLWKVWTELLD

BRI3BP

86

Q8WY22
FALVDTKAVWFKKWM

TBC1D32

346

Q96NH3
FTTVKLLWIWDKMEK

C14orf28

101

Q4W4Y0
LTIIKKWSWMFQEHL

DNAH11

1121

Q96DT5
EEKTFWKEEKSFWEM

CCDC70

96

Q6NSX1
KKWMAEVDVFLKEEW

DMD

1061

P11532
WFRSLFWKEEMELTL

ARL8B

11

Q9NVJ2
WFKALFWKEEMELTL

ARL8A

11

Q96BM9
FKTKTWWLGLFLMLL

NIPAL3

71

Q6P499
WFWKAVLMMDSEKRI

NEDD4

1226

P46934
MLILFFLDSLIAWWE

SLC24A1

571

O60721
SLMVDWFWLIHEKQL

MICALL2

776

Q8IY33
KKWDFTALIDFWDKV

PARG

566

Q86W56
LAEWWELLFFIKKLD

CUL7

491

Q14999
MEFWLSWVLLVAILK

IGHV3-64D

1

A0A0J9YX35
EKFWEIWLMNEEEAK

DRC1

396

Q96MC2
KMFWIEATLLWRDIA

IL1RL1

351

Q01638
WLEWAIKEYSLMEID

FLI1

141

Q01543
NTFMEIWKKRWDKFI

ADA2

491

Q9NZK5
LDLWYLMFKEGWEHK

CYP4V2

241

Q6ZWL3
LKTWDMYREIWEINK

DNAH2

956

Q9P225
KWSELIKIVMSWFVS

SLC20A1

151

Q8WUM9
MEFWLSWVFLVAISK

IGHV3-53

1

P01767
AFFWWIALIKMDLSD

MYH15

11

Q9Y2K3
WQWFDGVMEVLKKHL

STAT5B

571

P51692
MEKRVIKWFDYLWTN

CNGA1

426

P29973
KMDDFWLLKELQTWL

CLCF1

181

Q9UBD9
LIWDLKMDWGLFDKN

XPR1

526

Q9UBH6
SKRLWKFFWEMDEAE

SPTB

636

P11277
LKEVWENMPKFDSLW

ZNF677

96

Q86XU0
QWFWKAVLLMDAEKR

NEDD4L

881

Q96PU5