Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionWnt receptor activity

FZD1 FZD8 FZD2

8.60e-05171033GO:0042813
GeneOntologyMolecularFunctionI-SMAD binding

SMAD2 SMAD5 SMAD9

8.60e-05171033GO:0070411
GeneOntologyBiologicalProcesskidney epithelium development

STAT1 EDNRB ROBO2 FGFR1 SDC1 SMAD2 SMAD5

1.71e-051621037GO:0072073
GeneOntologyCellularComponentheteromeric SMAD protein complex

SMAD2 SMAD5 SMAD9

6.58e-0681043GO:0071144
GeneOntologyCellularComponentSMAD protein complex

SMAD2 SMAD5 SMAD9

1.40e-05101043GO:0071141
DomainFRI

FZD1 FZD8 CORIN FZD2

3.95e-06201034SM00063
Domain-

FZD1 FZD8 CORIN FZD2

4.86e-062110341.10.2000.10
DomainFrizzled_dom

FZD1 FZD8 CORIN FZD2

8.51e-06241034IPR020067
DomainFZ

FZD1 FZD8 CORIN FZD2

8.51e-06241034PS50038
DomainFz

FZD1 FZD8 CORIN FZD2

8.51e-06241034PF01392
DomainDWB

SMAD2 SMAD5 SMAD9

8.94e-0681033SM00524
DomainMH2

SMAD2 SMAD5 SMAD9

8.94e-0681033PS51076
DomainMH1

SMAD2 SMAD5 SMAD9

8.94e-0681033PS51075
Domain-

SMAD2 SMAD5 SMAD9

8.94e-06810333.90.520.10
DomainMAD_homology_MH1

SMAD2 SMAD5 SMAD9

8.94e-0681033IPR013019
DomainDwarfin

SMAD2 SMAD5 SMAD9

8.94e-0681033IPR013790
DomainMH2

SMAD2 SMAD5 SMAD9

8.94e-0681033PF03166
DomainSMAD_dom_Dwarfin-type

SMAD2 SMAD5 SMAD9

8.94e-0681033IPR001132
DomainFrizzled

FZD1 FZD8 FZD2

2.60e-05111033IPR000539
DomainFrizzled

FZD1 FZD8 FZD2

2.60e-05111033PF01534
DomainDHR-1_domain

DOCK4 DOCK9 DOCK10

2.60e-05111033IPR027007
DomainDHR_2

DOCK4 DOCK9 DOCK10

2.60e-05111033PS51651
DomainDHR_1

DOCK4 DOCK9 DOCK10

2.60e-05111033PS51650
DomainDHR-2

DOCK4 DOCK9 DOCK10

2.60e-05111033PF06920
DomainDOCK

DOCK4 DOCK9 DOCK10

2.60e-05111033IPR026791
DomainDOCK_C

DOCK4 DOCK9 DOCK10

2.60e-05111033IPR010703
DomainDOCK-C2

DOCK4 DOCK9 DOCK10

2.60e-05111033PF14429
DomainDHR-2

DOCK4 DOCK9 DOCK10

2.60e-05111033IPR027357
DomainFrizzled

FZD1 FZD8 FZD2

2.60e-05111033SM01330
DomainMAD_homology1_Dwarfin-type

SMAD2 SMAD5 SMAD9

3.46e-05121033IPR003619
DomainDWA

SMAD2 SMAD5 SMAD9

3.46e-05121033SM00523
DomainMH1

SMAD2 SMAD5 SMAD9

3.46e-05121033PF03165
DomainSMAD_dom-like

SMAD2 SMAD5 SMAD9

8.66e-05161033IPR017855
Domain-

SMAD2 SMAD5 SMAD9

8.66e-051610332.60.200.10
DomainFrizzled/SFRP

FZD1 FZD8 FZD2

8.66e-05161033IPR015526
DomainSUMO_chordates

SUMO3 SUMO2

9.00e-0531032IPR027218
DomainSumo

SUMO3 SUMO2

1.79e-0441032IPR033950
DomainRad60-SLD

SUMO3 SUMO2

2.98e-0451032PF11976
DomainRad60/SUMO-like_dom

SUMO3 SUMO2

2.98e-0451032IPR022617
DomainDUF3398

DOCK9 DOCK10

4.45e-0461032PF11878
DomainDOCK_C/D_N

DOCK9 DOCK10

4.45e-0461032IPR021816
DomainARM-type_fold

IPO7 MROH2A DOCK9 COPG2 CWC22 ARFGEF3 LTN1 HTT

5.78e-043391038IPR016024
DomainARM-like

IPO7 MROH2A DOCK10 COPG2 CHIC1 LTN1 HTT

7.43e-042701037IPR011989
DomainMKP

DUSP4 DUSP5

1.32e-03101032IPR008343
DomainSMAD_FHA_domain

SMAD2 SMAD5 SMAD9

2.96e-03521033IPR008984
DomainDUF1605

DHX8 DHX15

3.88e-03171032IPR011709
DomainOB_NTP_bind

DHX8 DHX15

3.88e-03171032PF07717
DomainHA2

DHX8 DHX15

4.35e-03181032SM00847
DomainHA2

DHX8 DHX15

4.35e-03181032PF04408
DomainHelicase-assoc_dom

DHX8 DHX15

4.35e-03181032IPR007502
DomainGPCR_2_secretin-like

FZD1 FZD8 FZD2

4.44e-03601033IPR000832
DomainGPCR_2-like

FZD1 FZD8 FZD2

4.44e-03601033IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD1 FZD8 FZD2

4.65e-03611033PS50261
PathwayWP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING

DUSP4 CPT1A FZD1 FGFR1 SMAD2 SMAD5 SMAD9

3.28e-06108837M48078
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

STAT1 FZD1 FZD8 FGFR1 FZD2 SMAD5 SMAD9

5.91e-06118837M39852
PathwayREACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS

ESR1 NR1I2 SUMO3 SUMO2

2.05e-0528834MM15042
PathwayREACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS

ESR1 NR1I2 SUMO3 SUMO2

2.72e-0530834M27323
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

FZD1 FZD8 FGFR1 FZD2 SMAD5 SMAD9

6.14e-05116836MM15863
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

FZD1 FZD8 FGFR1 FZD2 SMAD5 SMAD9

6.45e-05117836M39530
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD1 FZD8 FZD2

6.84e-0514833M47834
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD1 FZD8 FZD2

1.04e-0416833M47823
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

NLRP3 FZD1 FZD8 FZD2

1.27e-0444834MM15878
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD1 FZD8 FZD2

1.78e-0419833M47833
PathwayWP_ENDODERM_DIFFERENTIATION

MBTD1 DUSP4 DUSP5 STAT1 JARID2 SMAD2

1.95e-04143836M39591
PathwayWP_TGFBETA_SIGNALING_PATHWAY

STAT1 SMAD2 SMAD5 SMAD9

2.63e-0453834MM15880
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

MBTD1 FZD8 JARID2 FGFR1 SMAD2 HTT

2.81e-04153836M39546
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

STAT1 SMAD2 SMAD5 SMAD9

3.03e-0455834M39351
PathwayREACTOME_SUMO_IS_CONJUGATED_TO_E1_UBA2_SAE1

SUMO3 SUMO2

3.39e-045832M27223
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

STAT1 SMAD2 SMAD5 SMAD9

3.97e-0459834M39886
PathwayBIOCARTA_SUMO_PATHWAY

SUMO3 SUMO2

5.06e-046832M22055
PathwayKEGG_MEDICUS_REFERENCE_NLRP3_INFLAMMASOME_SIGNALING_PATHWAY

NLRP3 IL33

5.06e-046832M47624
PathwayREACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED

SUMO3 SUMO2

5.06e-046832M27225
PathwayPID_WNT_SIGNALING_PATHWAY

FZD1 FZD8 FZD2

5.80e-0428833M77
PathwayBIOCARTA_SUMO_PATHWAY

SUMO3 SUMO2

7.06e-047832MM1570
PathwayKEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY

SMAD5 SMAD9

7.06e-047832M47845
PathwayREACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED

SUMO3 SUMO2

7.06e-047832MM14928
PathwayREACTOME_SUMO_IS_TRANSFERRED_FROM_E1_TO_E2_UBE2I_UBC9

SUMO3 SUMO2

7.06e-047832M27224
PathwayKEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY

SMAD5 SMAD9

9.37e-048832M47847
PathwayWP_ENDOTHELIN_PATHWAYS

CAD ECE1 EDNRB

9.45e-0433833M39651
Pubmed

GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.

ESR1 SMAD2 SMAD5 SMAD9

1.01e-089106424932701
Pubmed

Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon.

FGFR1 SMAD2 SMAD5 SMAD9

1.44e-0716106421939397
Pubmed

Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

SMAD2 SMAD5 SMAD9

2.74e-075106325141865
Pubmed

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

FGFR1 SMAD2 SMAD5 SMAD9

3.80e-0720106418653563
Pubmed

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.

FGFR1 SMAD2 SMAD5 SMAD9

3.80e-0720106432662771
Pubmed

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.

STAT1 FGFR1 SMAD5 SMAD9

4.69e-0721106417065231
Pubmed

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.

SMAD2 SMAD5 SMAD9

5.47e-076106321518886
Pubmed

Smad7 is required for the development and function of the heart.

SMAD2 SMAD5 SMAD9

5.47e-076106318952608
Pubmed

Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.

SMAD2 SMAD5 SMAD9

5.47e-076106311850197
Pubmed

Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.

SMAD2 SMAD5 SMAD9

9.55e-077106315009097
Pubmed

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

SMAD2 SMAD5 SMAD9

9.55e-077106311163184
Pubmed

Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.

SMAD2 SMAD5 SMAD9

9.55e-077106315376321
Pubmed

A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.

SMAD2 SMAD5 SMAD9

1.52e-068106319211612
Pubmed

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

SMAD2 SMAD5 SMAD9

1.52e-068106310647776
Pubmed

Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.

SMAD2 SMAD5 SMAD9

1.52e-068106323804438
Pubmed

TGF-beta signaling by Smad proteins.

SMAD2 SMAD5 SMAD9

1.52e-068106310708949
Pubmed

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation.

STAT1 FGFR1 SMAD5 SMAD9

1.58e-0628106419224984
Pubmed

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.

CAD DOCK9 DHX8 SMAD2 SMAD5

1.71e-0665106518729074
Pubmed

Holding their own: the noncanonical roles of Smad proteins.

SMAD2 SMAD5 SMAD9

2.28e-069106319018011
Pubmed

TGF-beta signal transduction.

SMAD2 SMAD5 SMAD9

2.28e-06910639759503
Pubmed

Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.

SMAD2 SMAD5 SMAD9

2.28e-069106330134160
Pubmed

Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5.

SMAD2 SMAD5 SMAD9

2.28e-069106315993878
Pubmed

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.

SMAD2 SMAD5 SMAD9

2.28e-069106324816837
Pubmed

Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.

SMAD2 SMAD5 SMAD9

2.28e-069106314729481
Pubmed

Prdm16 is required for normal palatogenesis in mice.

SMAD2 SMAD5 SMAD9

2.28e-069106320007998
Pubmed

Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-β signaling.

SMAD2 SMAD5 SMAD9

2.28e-069106325155999
Pubmed

The Smad pathway.

SMAD2 SMAD5 SMAD9

2.28e-069106310708948
Pubmed

The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development.

FGFR1 SMAD2 SMAD5 SMAD9

2.74e-0632106425428587
Pubmed

TGF-β signaling inhibits canonical BMP signaling pathway during palate development.

SMAD2 SMAD5 SMAD9

3.25e-0610106329247325
Pubmed

Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis.

SMAD2 SMAD5 SMAD9

3.25e-0610106323620745
Pubmed

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.

SMAD2 SMAD5 SMAD9

3.25e-0610106329986157
Pubmed

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

SMAD2 SMAD5 SMAD9

3.25e-061010639436979
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD1 FZD8 FZD2

3.25e-0610106315245425
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD1 FZD8 FZD2

3.25e-0610106317532316
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

BORCS6 PDXDC1 SNX4 LAMTOR2 ECE1 BLOC1S2 RUFY3 ARFGEF3 VPS13B SMAD2

3.44e-065041061034432599
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD1 FZD8 FZD2

4.46e-0611106324860427
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD1 FZD8 FZD2

4.46e-0611106330978219
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD1 FZD8 FZD2

4.46e-0611106317576136
Pubmed

Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor Agenesis and Molar Microdontia.

FGFR1 SMAD5 SMAD9

4.46e-0611106339000154
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD1 FZD8 FZD2

4.46e-0611106317582687
Pubmed

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.

SMAD2 SMAD5 SMAD9

4.46e-0611106327741240
Pubmed

Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertension.

SMAD2 SMAD5 SMAD9

4.46e-0611106324008158
Pubmed

Smad7-induced beta-catenin degradation alters epidermal appendage development.

SMAD2 SMAD5 SMAD9

4.46e-0611106316950122
Pubmed

Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

FGFR1 SMAD2 SMAD5 SMAD9

4.98e-0637106423592779
Pubmed

BMPR-II is dispensable for formation of the limb skeleton.

SMAD2 SMAD5 SMAD9

5.93e-0612106321538804
Pubmed

Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.

SMAD2 SMAD5 SMAD9

5.93e-0612106315923624
Pubmed

Smad expression during kidney development.

SMAD2 SMAD5 SMAD9

5.93e-0612106314656760
Pubmed

Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.

SMAD2 SMAD5 SMAD9

5.93e-0612106317460146
Pubmed

Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2.

SMAD2 SMAD5 SMAD9

5.93e-0612106330664861
Pubmed

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.

SMAD2 SMAD5 SMAD9

7.70e-0613106316959237
Pubmed

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse.

SMAD2 SMAD5 SMAD9

7.70e-0613106318329379
Pubmed

Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation.

SUMO3 SUMO2 SMAD2

7.70e-0613106323530056
Pubmed

Endoglin is required for myogenic differentiation potential of neural crest stem cells.

SMAD2 SMAD5 SMAD9

7.70e-0613106317628518
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

PDXDC1 IPO7 COPG2 COPS2 CWC22 DHX8 PPP1R10 CDC16 LTN1 PRMT3

8.64e-065601061035241646
Pubmed

Estrogen receptor-α signaling increases allergen-induced IL-33 release and airway inflammation.

ESR1 IL33

9.20e-062106232648964
Pubmed

Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells.

NLRP3 NR1I2

9.20e-062106225202020
Pubmed

STAT1 facilitates oestrogen receptor α transcription and stimulates breast cancer cell proliferation.

ESR1 STAT1

9.20e-062106230334368
Pubmed

PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex.

RPS2 PRMT3

9.20e-062106218573314
Pubmed

STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection.

STAT1 IL33

9.20e-062106228576981
Pubmed

Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer.

ESR1 FGFR1

9.20e-062106228751448
Pubmed

Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.

SUMO3 SUMO2

9.20e-062106210692421
Pubmed

Genetic variation in physiological sensitivity to estrogen in mice.

ESR1 SMAD2

9.20e-062106211478683
Pubmed

The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.

SUMO3 SUMO2

9.20e-062106218565875
Pubmed

SUMOylation of nuclear actin.

SUMO3 SUMO2

9.20e-062106219635839
Pubmed

Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.

OTUD6A NLRP3

9.20e-062106236932155
Pubmed

Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes.

STAT1 IL33

9.20e-062106228447741
Pubmed

Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer.

NR1I2 SLCO1A2

9.20e-062106219010908
Pubmed

Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.

FGFR1 SDC1

9.20e-062106232530114
Pubmed

Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor.

ESR1 NR1I2

9.20e-062106219011999
Pubmed

SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner.

SUMO3 SUMO2

9.20e-062106221291420
Pubmed

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.

FZD1 FZD2

9.20e-062106220189955
Pubmed

Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

DHX8 DHX15

9.20e-06210627935475
Pubmed

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3).

RPS2 PRMT3

9.20e-062106215473865
Pubmed

Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice.

RPS2 PRMT3

9.20e-062106217439947
Pubmed

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response.

SUMO3 SUMO2

9.20e-062106229891701
Pubmed

Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1.

SP110 STAT1

9.20e-062106226590945
Pubmed

Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.

SUMO3 SUMO2

9.20e-062106225047847
Pubmed

SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.

SUMO3 SUMO2

9.20e-062106222306003
Pubmed

Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development.

SMAD2 SMAD5 SMAD9

9.77e-0614106317670744
Pubmed

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function.

SMAD2 SMAD5 SMAD9

9.77e-0614106338951500
Pubmed

Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture.

SMAD2 SMAD5 SMAD9

9.77e-0614106333248111
Pubmed

The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.

SMAD2 SMAD5 SMAD9

9.77e-0614106316790475
Pubmed

Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis.

SMAD2 SMAD5 SMAD9

9.77e-0614106323238123
Pubmed

An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis.

SMAD2 SMAD5 SMAD9

9.77e-0614106325274628
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK4 DOCK9 DOCK10

9.77e-0614106312432077
Pubmed

The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.

FGFR1 SMAD5 SMAD9

9.77e-0614106320847311
Pubmed

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

SMAD2 SMAD5 SMAD9

9.77e-0614106316435884
Pubmed

Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.

ESR1 ECE1 EDNRB NR1I2 SMAD2

1.06e-0594106520346360
Pubmed

Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.

SMAD2 SMAD5 SMAD9

1.22e-0515106323011393
Pubmed

Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice.

SMAD2 SMAD5 SMAD9

1.22e-0515106326116174
Pubmed

Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development.

SMAD2 SMAD5 SMAD9

1.22e-0515106323946498
Pubmed

Genomic analysis of mouse retinal development.

MBTD1 ESR1 DUSP5 CPT1A ECE1 RUFY3 FZD1 FZD8 PPP1R10 MBNL2 SV2B FGFR1 FZD2

1.22e-0510061061315226823
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

IPO7 SMAD2 SMAD5 SMAD9

1.43e-0548106427703004
Pubmed

SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.

SUMO3 SUMO2 SMAD2

1.50e-0516106338925188
Pubmed

Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.

SMAD2 SMAD5 SMAD9

1.50e-0516106319556507
Pubmed

SMAD4 is essential for generating subtypes of neurons during cerebellar development.

SMAD2 SMAD5 SMAD9

1.81e-0517106322370000
Pubmed

Disrupted tenogenesis in masseter as a potential cause of micrognathia.

FGFR1 SMAD5 SMAD9

1.81e-0517106336257937
Pubmed

Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.

FGFR1 SMAD5 SMAD9

1.81e-0517106318832393
Pubmed

Smad7 regulates terminal maturation of chondrocytes in the growth plate.

SMAD2 SMAD5 SMAD9

1.81e-0517106323994637
Pubmed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

FZD1 FZD8 FZD2

1.81e-0517106328733458
GeneFamilySMAD family

SMAD2 SMAD5 SMAD9

4.77e-068813750
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD1 FZD8 FZD2

1.39e-0511813286
GeneFamilyBiogenesis of lysosomal organelles complex 1 |BLOC-1 related complex

BORCS6 BLOC1S2

5.45e-0488121048
GeneFamilyMAP kinase phosphatases

DUSP4 DUSP5

1.06e-0311812895
GeneFamilyDEAH-box helicases

DHX8 DHX15

2.28e-0316812500
CoexpressionGU_PDEF_TARGETS_UP

DOCK4 DOCK10 FZD1 FZD8 SDC1 SMAD2

4.39e-07711066M3955
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZDHHC18 DUSP4 DUSP5 DOCK10 CCDC81 NLRP3 JARID2

3.96e-071941057f0467d81063a9b19783906c456935ef8318b9b98
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

DUSP4 DUSP5 ACKR4 NLRP3 JARID2 FGFR1

1.99e-0615710567ceae5fe00c91d4feb8c314d3a31f027c03fa56f
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT3 CYP4B1 ACKR4 ITGB5 EDNRB EMP2

5.28e-0618610569d6cb36aa0aae69fe584dad31deafcfdcc9fd1db
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CYP4B1 MROH2A ECE1 CST6 EMP2 SDC1

5.44e-061871056f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)-|368C / Donor, Lineage, Cell class and subclass (all cells)

SLC25A16 FZD8 CST6 ZNF432 GAN EMP2

5.61e-061881056c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)|368C / Donor, Lineage, Cell class and subclass (all cells)

SLC25A16 FZD8 CST6 ZNF432 GAN EMP2

5.61e-0618810569155b9a92496e75646778c025b02947e9e9ec73a
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT3 CYP4B1 ACKR4 ITGB5 EDNRB EMP2

6.33e-061921056f094ac378e635cf5820e8a8b7a0152073a51ceae
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 DOCK9 ECE1 EMP2 IL33 SMAD9

6.52e-0619310560b328f725f6feba263783eaca60c142e80df90f3
ToppCelldroplet-Lung-21m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TEKT3 CYP4B1 ACKR4 ITGB5 EDNRB EMP2

6.52e-0619310563a5ad8ffad441e30a6e1bd017da7720ad57f6c57
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

DOCK9 DUSP4 DUSP5 ECE1 CST6 EMP2

6.72e-061941056b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT3 CYP4B1 ACKR4 ITGB5 EDNRB EMP2

6.92e-061951056cad21edd90bf3e2fefdf5773a59cb1a664a69ddd
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TEKT3 CYP4B1 ACKR4 ITGB5 EDNRB EMP2

6.92e-0619510567e0ef92059ff34e368d2324815f49b50e3ca7332
ToppCellASK452-Epithelial-Type_1|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

CYP4B1 SLCO1A2 SLC25A15 CST6 EMP2 SDC1

7.33e-061971056dc0a6dca4af6b216357b06f67203274f8b2a8bb0
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FZD1 FZD8 FGFR1 EMP2 FZD2 SDC1

7.33e-0619710563fe665c0277d091290b63f0dd24c0c6536a45309
ToppCellASK428-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

DOCK4 CYP4B1 ACKR4 SLCO1A2 CST6 EMP2

7.55e-0619810560047a9ef7684230ac5179efea94461480e90bdaf
ToppCellproximal-Epithelial-Alveolar_Epithelial_Type_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 ACKR4 SLCO1A2 CST6 EMP2 SDC1

7.99e-062001056b652bc73adfdeccbdcd74497ab6e2085e5c95e88
ToppCellproximal-Epithelial-Alveolar_Epithelial_Type_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 ACKR4 SLCO1A2 CST6 EMP2 SDC1

7.99e-062001056c1345893e6947ccf9b41282d0e4428dbfb8bcc27
ToppCellproximal-3-Epithelial-Alveolar_Epithelial_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 ACKR4 SLCO1A2 CST6 EMP2 SDC1

7.99e-06200105651f8fc43c069f2c4e75588d28ae6deb5d7ed2c86
ToppCellClub_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

DUSP4 ARFGEF3 SLCO1A2 GAN SDC1

3.76e-051591055a7bcff268b1962a561fd2848e01ae16565bce895
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP4B1 ITGB5 DNAH14 ARFGEF3 ROBO2

3.99e-0516110557c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESR1 DUSP4 NLRP3 UGT2A3 IL33

3.99e-051611055b9a63fc9becc44d305fc7c221283bf59ec06b10f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CYP4B1 DOCK9 COPG2 EDNRB EMP2

5.02e-0516910558a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT3 DTNB DUSP4 DUSP5 SLAMF6

5.46e-051721055ce444463f69bbb05c933615a0f1f43ddde3eee1c
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT3 DTNB DUSP4 DUSP5 SLAMF6

5.46e-0517210552c993a93ac91dcf6061eec001f51f8cccb6ee264
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 ECE1 NLRP3 LTN1 SNTB1

5.46e-0517210557fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 ECE1 NLRP3 LTN1 SNTB1

5.46e-0517210552a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESR1 DUSP4 COPG2 SLAMF6 IL33

5.93e-0517510559a96794df049d8228fea57c1584c160191d36b56
ToppCell5'-Adult-LymphNode-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESR1 DUSP5 MBNL2 ANKRD36 SDC1

5.93e-0517510556a093c74a6f3daeff07759d6eec542fc5c709149
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

CYP4B1 ACKR4 CST6 EMP2 SDC1

6.09e-051761055458720776b0151cd55acc352d509599cb62f0ca8
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CAD ITGB5 DHX8 POLR1B PRDM15

6.43e-0517810559d575902d3dbe33437c9d4200df093a741269803
ToppCellfacs|World / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 DUSP5 ECE1 EMP2 SDC1

6.60e-0517910558001db3044e8657980e24422377c4fdb0d7b323e
ToppCellAT1_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CYP4B1 FZD8 CST6 EMP2 SDC1

6.60e-0517910551603117b52623663458a977c94bf7f9f6c1114b8
ToppCellfrontal_cortex-Non-neuronal|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CPT1A ITGB5 EDNRB EMP2 FZD2

6.60e-051791055ef01478bd03eb00f0ff2b6a8ae9244687c5f85aa
ToppCellAT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FMO5 CYP4B1 ROBO2 EMP2 SDC1

6.95e-051811055ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCellCOPD-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

DOCK4 ECE1 NLRP3 JARID2 DENND10

7.51e-051841055ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX4 DUSP4 ACKR4 EDNRB FGFR1

7.71e-051851055efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX4 DUSP4 ACKR4 EDNRB FGFR1

7.71e-051851055642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCellASK454-Epithelial-Type_1|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CYP4B1 CST6 EMP2 FZD2 SDC1

8.32e-05188105513f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 ACKR4 ITGB5 EDNRB EMP2

8.53e-05189105509dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK9 DUSP4 ACKR4 EMP2 IL33

8.53e-051891055b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP4B1 ACKR4 ITGB5 EDNRB EMP2

8.74e-05190105552213cd2a6a20772d4f49ba9ac0407abafa528db
ToppCellControl-Myeloid-cDC2|World / Disease state, Lineage and Cell class

DOCK4 DUSP4 DUSP5 NLRP3 JARID2

8.96e-05191105511dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP4B1 ACKR4 CST6 EMP2 SDC1

8.96e-051911055a15e34ad7dbf3f2f13d5e23ce3ffb6d08fd1f9f0
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 CST6 EMP2 FZD2 SDC1

8.96e-051911055ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 DOCK9 DUSP5 SV2B FGFR1

8.96e-0519110552f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP4B1 ACKR4 ITGB5 EDNRB EMP2

8.96e-05191105540e617d3c93f03ae87baf6c0b2304b617f5fe782
ToppCellfacs-Lung-Endomucin_-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 DOCK9 ECE1 ACKR4 SNTB1

9.18e-051921055ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DUSP4 DUSP5 ACKR4 SLAMF6 NR1I2

9.18e-0519210551b0138fd0bfdee266325751f8b2d163d91a71bf5
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP4B1 ACKR4 ITGB5 EDNRB EMP2

9.18e-051921055ff435141329e3e29fa9b08a4d5b2f55074e7f9ab
ToppCellhuman_hepatoblastoma-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CPT1A ECE1 NR1I2 SLC25A15 EMP2

9.18e-051921055e785135262f4c9cc66c403bf362bb34643b212c5
ToppCellfacs-Lung-Endomucin_|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 DOCK9 ECE1 ACKR4 SNTB1

9.18e-05192105585d4d0df701451daf95e94a87a0096da1e86533b
ToppCellEndothelial-Endothelial-B|Endothelial / shred on cell class and cell subclass (v4)

CYP4B1 DUSP4 EDNRB FGFR1 EMP2

9.18e-051921055f8d7bd81e031d09a557722627c2f6180811cc6ab
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 DOCK9 ECE1 ACKR4 SNTB1

9.41e-0519310552218833749576ba1a0fc95bd155c781e7e1163c6
ToppCelldroplet-Lung-nan-21m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT3 CYP4B1 ACKR4 EDNRB EMP2

9.41e-051931055ffdcbc5caff7fd4cc2e83dd21a05d43b0593d542
ToppCellCF-Epithelial|CF / Disease state, Lineage and Cell class

DOCK9 DUSP5 CST6 EMP2 SDC1

9.41e-051931055518901c2e36a79c6189cd0d9e6d36dbd4f56a79c
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA3A DOCK9 EDNRB SV2B IL33

9.41e-051931055bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCelldroplet-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TEKT3 CYP4B1 ACKR4 EDNRB EMP2

9.41e-05193105525129080f8a40b2988a5d9dfec36ff9e72c27e61
ToppCellCF-Epithelial-Epithelial_cell|CF / Disease state, Lineage and Cell class

DOCK9 DUSP5 CST6 EMP2 SDC1

9.41e-0519310554e3dda27c71b7fdac90d081f0d8e9ca3a8ea7820
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP4B1 ECE1 ACKR4 EDNRB EMP2

9.64e-051941055e13923860a64ba9cf32df53c9f0cf4e7c321881d
ToppCellCTRL-Myeloid-Monocyte_Macrophage|Myeloid / Disease state, Lineage and Cell class

DOCK4 DUSP4 JARID2 CST6 KDM7A

9.64e-05194105573459ee062ae1f1a3bb9719dc0b89aae10600e22
ToppCellCTRL-Epithelial-Epithelial_cell|CTRL / Disease state, Lineage and Cell class

DOCK9 DUSP5 CST6 EMP2 SDC1

9.64e-0519410552bc4deaf2a01a39809fc323962fce4286835209c
ToppCelldroplet-Lung-LUNG-1m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 ECE1 ACKR4 EDNRB EMP2

9.64e-05194105568efc6df31479839a3bd5fe9fbc98ddceecc3b10
ToppCellfacs-Lung-Endomucin_-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 DOCK9 ECE1 ACKR4 SNTB1

9.64e-051941055df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

CYP4B1 FZD8 CST6 EMP2 SMAD5

9.64e-05194105588db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

CYP4B1 FZD8 CST6 EMP2 SMAD5

9.64e-051941055a71728202493d4858342ea2756ea281cd0d99a3a
ToppCelldistal-1-Hematologic-Myeloid_Dendritic_Type_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZDHHC18 DUSP4 DUSP5 CCDC81 NLRP3

9.64e-05194105585a4be291c25ad1fb14199b87d822cf47d748fc0
ToppCellCTRL-Epithelial|CTRL / Disease state, Lineage and Cell class

DOCK9 DUSP5 CST6 EMP2 SDC1

9.64e-05194105549dcb31427f370692308f939e23992925708abb7
ToppCelldroplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 ECE1 ACKR4 EDNRB EMP2

9.64e-05194105503985e4ab10f140f758e70dc7bfaa059b4e3bb18
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP4B1 ECE1 ACKR4 EDNRB EMP2

9.64e-05194105586508dd9b9d345b6624d185048cc92b81dd11c2a
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

DOCK4 DOCK9 DUSP5 EDNRB FGFR1

9.87e-051951055a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellASK428|World / Donor, Lineage and Cell class of Lung cells from Dropseq

RPS2 CYP4B1 SURF1 SUMO2 EMP2

9.87e-05195105541cbd7ea0bfab2db338b4ba0fc67cb3ae0d63d6d
ToppCellnormal_Lung-Epithelial_cells-AT1|normal_Lung / Location, Cell class and cell subclass

CYP4B1 SLCO1A2 CST6 EMP2 SDC1

9.87e-051951055569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCell(1)_Osterolineage_cells-(11)_OLC-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

COL6A5 ITGB5 FZD1 FGFR1 FZD2

9.87e-05195105578978d85273e5463a7f43e4c121e647fa6aba42b
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A5 FZD1 CORIN ROBO2 FGFR1

1.01e-041961055e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

DOCK4 DOCK9 ROBO2 FGFR1 IL33

1.01e-041961055e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP4B1 CST6 EMP2 FZD2 SDC1

1.01e-0419610556731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCellfacs-Skin-Telogen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 FZD1 FGFR1 FZD2 SDC1

1.01e-041961055c936014125b2ed5f796221b74acb77b8f8359875
ToppCellEpithelial_cells-AT1_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

DOCK4 CYP4B1 CST6 EMP2 FZD2

1.01e-0419610556c99d29162848161c1f166a032320f87a5d5a631
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP4B1 CST6 EMP2 FZD2 SDC1

1.01e-0419610556856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCellNS-critical-d_16-33-Epithelial-Squamous|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DUSP4 DUSP5 CST6 GAN SDC1

1.01e-04196105597e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCellmedial-Hematologic-Myeloid_Dendritic_Type_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DUSP4 DUSP5 DOCK10 NLRP3 JARID2

1.04e-0419710555bd2f32137fd849931e52093d630d2e7e27daf4f
ToppCellmedial-Hematologic-Myeloid_Dendritic_Type_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DUSP4 DUSP5 DOCK10 NLRP3 JARID2

1.04e-041971055d9baa0be469fd8737a74b5078d30ce7d66759160
ToppCellmedial-2-Hematologic-Myeloid_Dendritic_Type_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DUSP4 DUSP5 DOCK10 NLRP3 JARID2

1.04e-0419710553c1147857de6a7ab6b0cf77f5a6364d4c8669693
ToppCellAT1_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

CYP4B1 CST6 EMP2 FZD2 SDC1

1.04e-04197105580d81be244c94c435accb643449b4ce6a3462c7f
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

ZDHHC18 DUSP4 DUSP5 CCDC81 RUFY3

1.04e-041971055c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCellASK440-Epithelial-Type_1|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CYP4B1 SLCO1A2 CST6 EMP2 FZD2

1.04e-0419710551eda2c2504451a3d626dda5c2b2b12eeaa6bca54
ToppCellASK440-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CYP4B1 ACKR4 SLCO1A2 EMP2 FZD2

1.04e-041971055782449c522c9e16e72bf999a73090688a3aefe06
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DOCK4 NLRP3 CST6 KDM7A FZD2

1.06e-04198105559214e34b077dffa989c48635fdef143f57f1320
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CYP4B1 ARFGEF3 ROBO2 SDC1 CERS4

1.06e-041981055a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCellmoderate-Epithelial-Secretory|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CYP4B1 ARFGEF3 GAN EMP2 SDC1

1.06e-0419810557d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DOCK4 NLRP3 CST6 KDM7A FZD2

1.06e-0419810557f7024b26337ae2bc7f57c3274a7dfdaaa64ab7c
ToppCellmedial-2-Epithelial-Alveolar_Epithelial_Type_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 SLCO1A2 CST6 EMP2 SDC1

1.09e-041991055456460c761e26ed4b1d88d9bee4d2a7c9bd9d416
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DUSP4 DOCK10 EDNRB SV2B SNTB1

1.09e-041991055ce699726ac4825c65bf934cb9a76202ad7340596
ToppCellmedial-Epithelial-Alveolar_Epithelial_Type_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 SLCO1A2 CST6 EMP2 SDC1

1.09e-0419910555263338242f95c04690d0795749ccc20b0d19f7a
ToppCellIPF-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

DOCK4 NLRP3 JARID2 CST6 TDRD6

1.09e-0419910553c2b362d5e824e1a04830e70352f8818de984174
ToppCellASK452-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CYP4B1 SLCO1A2 CST6 EMP2 SDC1

1.09e-04199105548cafe44951908d03f3c6f3e185e9cbb86fb5b3b
ToppCellTracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DUSP4 DUSP5 DOCK10 NLRP3 IL22RA2

1.09e-0419910557b3d4c62b11268c7c1599600d8a7b331287cf21a
ToppCellmedial-Epithelial-Alveolar_Epithelial_Type_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 SLCO1A2 CST6 EMP2 SDC1

1.09e-041991055c11365653c69a5dfb37946231f8af05149a61a71
ToppCellLung_Parenchyma-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FMO5 CYP4B1 ARFGEF3 EMP2 SDC1

1.11e-042001055c2bde99b3bc7a8740441c1a0c1394892b940b857
ToppCelldistal-2-Epithelial-Alveolar_Epithelial_Type_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP4B1 SLCO1A2 CST6 EMP2 SDC1

1.11e-042001055313ec1e53bd738a9cb48dc5b946261156f99f44b
DrugNaringin hydrate [11032-30-7]; Down 200; 6.6uM; MCF7; HT_HG-U133A

CYP4B1 ESR1 DUSP4 ECE1 STAT1 MBNL2 FGFR1 VPS13B SMAD5

3.31e-0719510693286_DN
DrugPrenylamine lactate [69-43-2]; Up 200; 9.6uM; HL60; HG-U133A

DOCK4 DUSP4 ECE1 SP110 STAT1 NLRP3 MBNL2 HTT

2.40e-0618410681737_UP
DrugGabexate mesilate [56974-61-9]; Down 200; 9.6uM; HL60; HT_HG-U133A

ZDHHC18 ESR1 CPT1A NLRP3 MBNL2 KDM7A ZNF839 VPS13B

3.17e-0619110682937_DN
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; HL60; HT_HG-U133A

DOCK4 ECE1 SP110 STAT1 RUFY3 FGFR1 ZNF614 SMAD5

3.42e-0619310682477_DN
DrugClindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; PC3; HT_HG-U133A

BORCS6 MBTD1 ESR1 DOCK9 FZD8 FGFR1 KDM7A SMAD5

4.13e-0619810682057_UP
DrugBromperidol [10457-90-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

MBTD1 CPT1A SP110 SURF1 FGFR1 ZNF614 VPS13B SMAD5

4.29e-0619910682872_DN
Drugbenidipine

ESR1 ECE1 EDNRB NR1I2

7.17e-06271064ctd:C061004
Drugoctamethylcyclotetrasiloxane

ESR1 NR1I2

2.15e-0521062ctd:C024064
DrugEthinyl Estradiol

ESR1 NR1I2

2.15e-0521062DB00977
DrugLoperamide hydrochloride [34552-83-5]; Up 200; 7.8uM; PC3; HT_HG-U133A

DOCK9 FZD1 MBNL2 SV2B CNTN5 KDM7A SNTB1

2.96e-0518910674672_UP
DrugLorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

ESR1 DUSP4 STAT1 RUFY3 MBNL2 FGFR1 ZNF614

2.96e-0518910675254_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A

DOCK4 DUSP4 TWF2 MBNL2 FGFR1 KDM7A SMAD5

3.28e-0519210674743_DN
DrugTriprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ZDHHC18 CPT1A SLC25A16 STAT1 RUFY3 POLR1B FGFR1

3.39e-0519310677008_DN
DrugClorsulon [60200-06-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

ESR1 CPT1A ECE1 SP110 FZD1 FGFR1 VPS13B

3.62e-0519510672884_DN
DrugFluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; HL60; HT_HG-U133A

BORCS6 CPT1A NLRP3 RUFY3 KDM7A ZNF614 SMAD5

3.74e-0519610673032_DN
DrugMethoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; MCF7; HT_HG-U133A

BORCS6 MBTD1 ESR1 ECE1 SP110 MBNL2 CERS4

3.74e-0519610673302_DN
DrugEdrophonium chloride [116-38-1]; Up 200; 19.8uM; PC3; HT_HG-U133A

ESR1 DOCK10 RUFY3 SV2B POLR1B SNTB1 CERS4

3.74e-0519610676655_UP
DrugU-62066 [87151-85-7]; Up 200; 1uM; MCF7; HT_HG-U133A

FMO5 DOCK9 CNTLN ECE1 RUFY3 AKAP4 CERS4

3.99e-0519810674375_UP
DrugLaudanosine (R,S) [1699-51-0]; Up 200; 11.2uM; PC3; HT_HG-U133A

MBTD1 CNTN5 CST6 FGFR1 KDM7A ZNF839 VPS13B

3.99e-0519810677270_UP
Drug(S)-propranolol hydrochloride [4199-10-4]; Down 200; 13.6uM; HL60; HT_HG-U133A

ZDHHC18 NLRP3 RUFY3 SLC25A15 FZD2 HTT SMAD5

3.99e-0519810672961_DN
Drugcyanophenphos

ESR1 NR1I2

6.42e-0531062ctd:C002488
DrugEstradiol

ESR1 NR1I2

6.42e-0531062DB00783
DrugAC1L9M5J

FZD1 FZD8 FGFR1 SUMO3 SUMO2 FZD2 HTT

7.97e-052211067CID000448615
Drugenterodiol

ESR1 CPT1A NR1I2

9.00e-05191063CID000115089
DrugMaprotiline hydrochloride [10347-81-6]; Up 200; 12.8uM; MCF7; HT_HG-U133A

FMO5 RPS2 DOCK9 DUSP4 ECE1 MBNL2

1.08e-0416110665022_UP
Drugchloropropylate

ESR1 NR1I2

1.28e-0441062ctd:C004663
Drugethyl bromophos

ESR1 NR1I2

1.28e-0441062ctd:C041062
DrugPhenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester

ESR1 NR1I2

1.28e-0441062ctd:D004849
Drugisofenphos

ESR1 NR1I2

1.28e-0441062ctd:C035019
Drugdichlofenthion

ESR1 NR1I2

1.28e-0441062ctd:C011445
DrugPimozide [2062-78-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A

BORCS6 CYP4B1 DUSP4 MBNL2 CNTN5 VPS13B

1.28e-0416610666780_UP
DrugPrestwick_517

FZD1 FZD8 FGFR1 EMP2 FZD2

1.39e-041061065CID000003804
DrugTritolyl Phosphates

ESR1 NR1I2 SLCO1A2

1.42e-04221063ctd:D014317
DrugMG-262; Down 200; 0.1uM; PC3; HT_HG-U133A

DUSP4 FPGT FZD8 ZNF839 SDC1 IL33

1.61e-0417310667068_DN
Drugfluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A

BORCS6 DUSP4 MBNL2 GAN FGFR1 ZNF614

1.88e-0417810665234_UP
Drugchlorobenzilate

ESR1 NR1I2

2.13e-0451062ctd:C004659
Drugtolclofos-methyl

ESR1 NR1I2

2.13e-0451062ctd:C426783
Drugflucythrinate

ESR1 NR1I2

2.13e-0451062ctd:C027975
Drugschisandrol

NR1I2 GAN

2.13e-0451062CID005321168
Drugethion

ESR1 NR1I2

2.13e-0451062ctd:C100038
Drugisoprothiolane

ESR1 NR1I2

2.13e-0451062ctd:C023889
Drugprothiophos

ESR1 NR1I2

2.13e-0451062ctd:C032072
DrugTRAM 34

ESR1 NR1I2

2.13e-0451062ctd:C411671
DrugLeptophos

ESR1 NR1I2

2.13e-0451062ctd:D010773
DrugHexetidine [141-94-6]; Up 200; 11.8uM; HL60; HT_HG-U133A

DOCK4 FMO5 DUSP4 SP110 STAT1 MBNL2

2.31e-0418510662457_UP
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ESR1 TWF2 JARID2 ZNF839 FZD2 VPS13B

2.52e-0418810666451_DN
Drugtriphenyl phosphate

FMO5 ESR1 NR1I2 SLCO1A2 CORIN

2.58e-041211065ctd:C005445
DrugTestosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A

MBTD1 ESR1 DOCK10 MBNL2 FGFR1 ZNF614

2.67e-0419010665271_DN
DrugTetrahydrozoline hydrochloride [522-48-5]; Down 200; 16.8uM; MCF7; HT_HG-U133A

ESR1 ECE1 STAT1 FZD1 MBNL2 FGFR1

2.67e-0419010666769_DN
Drug3,4,3',4'-tetrachlorobiphenyl

FMO5 ESR1 DOCK9 CPT1A NR1I2 SURF1 UGT2A3 UQCC1 SMAD9

2.70e-044531069ctd:C028451
DrugDesipramine hydrochloride [58-28-6]; Up 200; 13.2uM; PC3; HT_HG-U133A

ESR1 DUSP5 GAN FGFR1 KDM7A SNTB1

2.74e-0419110666693_UP
DrugBenfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A

DOCK9 DUSP4 SP110 STAT1 RUFY3 MBNL2

2.74e-0419110665327_UP
DrugHymecromone [90-33-5]; Down 200; 22.8uM; PC3; HT_HG-U133A

FMO5 DTNB ECE1 STAT1 MBNL2 ZNF614

2.90e-0419310664623_DN
DrugPrednicarbate [73771-04-7]; Down 200; 8.2uM; PC3; HT_HG-U133A

MBTD1 ESR1 FZD8 MBNL2 ZNF839 VPS13B

2.90e-0419310665119_DN
Drugfelodipine; Down 200; 10uM; MCF7; HT_HG-U133A_EA

ESR1 TWF2 FPGT CPT1A FZD2 SMAD5

2.90e-041931066965_DN
DrugSerotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A

RPS2 DOCK10 FZD1 MBNL2 FGFR1 KDM7A

2.98e-0419410665268_DN
DrugAG-013608 [351320-38-2]; Up 200; 10uM; PC3; HT_HG-U133A

ESR1 NLRP3 RUFY3 FZD1 NR1I2 FGFR1

2.98e-0419410665909_UP
DrugDosulepin hydrochloride [897-15-4]; Down 200; 12uM; MCF7; HT_HG-U133A

RPS2 CYP4B1 ESR1 ITGB5 SURF1 FGFR1

2.98e-0419410662864_DN
DrugDanazol [17230-88-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ZDHHC18 FPGT CPT1A SP110 CDC16 SMAD5

3.06e-0419510665315_DN
DrugSelegiline hydrochloride [14611-52-0]; Down 200; 17.8uM; MCF7; HT_HG-U133A

ESR1 DOCK9 CPT1A STAT1 RUFY3 SURF1

3.06e-0419510662826_DN
DrugThiamphenicol [15318-45-3]; Down 200; 11.2uM; HL60; HT_HG-U133A

ITGB5 RUFY3 FGFR1 KDM7A ZNF614 SNTB1

3.06e-0419510661867_DN
DrugDehydrocholic acid [81-23-2]; Down 200; 9.6uM; MCF7; HT_HG-U133A

MBTD1 ESR1 RUFY3 MBNL2 FGFR1 HTT

3.06e-0419510661523_DN
DrugOfloxacin [82419-36-1]; Down 200; 11uM; HL60; HT_HG-U133A

ZDHHC18 DUSP5 ECE1 RUFY3 SURF1 HTT

3.06e-0419510662340_DN
DrugSulfapyridine [144-83-2]; Down 200; 16uM; MCF7; HT_HG-U133A

MBTD1 RPS2 ESR1 ECE1 FZD1 FGFR1

3.06e-0419510666799_DN
DrugGlipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A

CCDC81 CPT1A SP110 EDNRB ZNF614 VPS13B

3.06e-0419510664991_UP
DrugPimethixene maleate [13187-06-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A

CPT1A SP110 STAT1 FZD1 FGFR1 SMAD5

3.06e-0419510667426_DN
Drug0198306-0000 [212631-61-3]; Down 200; 10uM; MCF7; HT_HG-U133A

DUSP4 DUSP5 CPT1A STAT1 MBNL2 KDM7A

3.06e-0419510667099_DN
DrugCloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; PC3; HT_HG-U133A

ZDHHC18 DOCK10 CPT1A FGFR1 ZNF614 SMAD5

3.06e-0419510662126_UP
Drugbeta-hexachlorocyclohexane

ESR1 CPT1A NR1I2 POLR1B EMP2

3.11e-041261065ctd:C023888
DrugCephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT_HG-U133A

DOCK4 ESR1 ECE1 ITGB5 STAT1 FGFR1

3.15e-0419610665615_DN
DrugCimetidine [51481-61-9]; Down 200; 15.8uM; PC3; HT_HG-U133A

CPT1A ECE1 MBNL2 GAN FGFR1 SMAD5

3.15e-0419610664063_DN
DrugAcetazolamide [59-66-5]; Up 200; 18uM; MCF7; HT_HG-U133A

BORCS6 ECE1 CST6 FGFR1 KDM7A SMAD5

3.15e-0419610661686_UP
Drug2-propylpentanoic acid; Up 200; 500uM; HL60; HT_HG-U133A

DOCK4 ESR1 DOCK9 DUSP4 CPT1A SMAD5

3.15e-0419610661181_UP
DrugCitalopram hydrobromide [59729-32-7]; Up 200; 1uM; PC3; HT_HG-U133A

BORCS6 DTNB SP110 NR1I2 FGFR1 CERS4

3.15e-0419610663820_UP
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; HL60; HT_HG-U133A

FMO5 DUSP4 SLC25A16 SP110 RUFY3 SMAD5

3.15e-0419610666141_DN
Drugikarugamycin; Up 200; 2uM; MCF7; HT_HG-U133A_EA

RPS2 ESR1 DUSP4 NLRP3 MBNL2 FGFR1

3.15e-041961066918_UP
DrugEtilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A

RPS2 ESR1 DOCK9 DOCK10 MBNL2 FGFR1

3.15e-0419610664415_UP
DrugPerhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A

FMO5 ESR1 CPT1A MBNL2 ZNF839 ZNF614

3.15e-0419610665081_DN
DrugLysergol [602-85-7]; Up 200; 15.8uM; MCF7; HT_HG-U133A

ESR1 TWF2 ITGB5 RUFY3 FGFR1 VPS13B

3.15e-0419610663261_UP
DrugY-27632; Down 200; 3uM; MCF7; HT_HG-U133A_EA

RPS2 ESR1 CPT1A SLC25A16 STAT1 SMAD5

3.15e-041961066832_DN
Drugflutolanil

ESR1 NR1I2

3.18e-0461062ctd:C475882
Drugisopropyl 4,4'-dibromobenzilate

ESR1 NR1I2

3.18e-0461062ctd:C038267
DrugDanazol

ESR1 GNRHR2

3.18e-0461062DB01406
Drugtestololactone

CAD ESR1

3.18e-0461062CID000160753
DrugR)-3-pyrrolidinecarboxylic acid

DTNB EDNRB

3.18e-0461062CID001501969
DrugLoracarbef [121961-22-6]; Down 200; 10.8uM; HL60; HT_HG-U133A

DUSP4 CPT1A ECE1 STAT1 FGFR1 SNTB1

3.24e-0419710662970_DN
DrugDomperidone maleate; Down 200; 7.4uM; PC3; HT_HG-U133A

MBTD1 DTNB ESR1 CNTLN SURF1 ZNF839

3.24e-0419710664640_DN
DrugFendiline hydrochloride [13636-18-5]; Down 200; 11.4uM; HL60; HG-U133A

RPS2 DOCK10 TWF2 UQCC1 PRMT3 ZNF839

3.24e-0419710661573_DN
DrugDydrogesterone [152-62-5]; Up 200; 12.8uM; HL60; HT_HG-U133A

DOCK4 FMO5 ECE1 ITGB5 RUFY3 FZD1

3.24e-0419710662156_UP
DrugLisinopril [83915-83-7]; Up 200; 9uM; HL60; HT_HG-U133A

ESR1 CNTLN CPT1A SP110 RUFY3 KDM7A

3.24e-0419710662371_UP
Drugnifedipine; Down 200; 10uM; MCF7; HG-U133A

ESR1 DUSP4 ECE1 RUFY3 DHX8 ZNF839

3.24e-041971066335_DN
DrugFlufenamic acid [530-78-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

DOCK10 NR1I2 MBNL2 CNTN5 FGFR1 VPS13B

3.24e-0419710662267_UP
DrugPodophyllotoxin [518-28-5]; Down 200; 9.6uM; MCF7; HT_HG-U133A

BORCS6 ESR1 ECE1 FGFR1 ZNF839 ZNF614

3.24e-0419710666103_DN
DrugFurazolidone [67-45-8]; Down 200; 17.8uM; HL60; HT_HG-U133A

FMO5 DOCK9 DUSP4 CPT1A FZD1 ZNF614

3.24e-0419710663019_DN
DrugRoxarsone [121-19-7]; Up 200; 15.2uM; PC3; HT_HG-U133A

FMO5 DTNB ESR1 DOCK10 FZD1 FGFR1

3.24e-0419710665051_UP
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

MBTD1 ECE1 FZD1 MBNL2 SURF1 ZNF839

3.24e-0419710666974_DN
DrugDihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; MCF7; HT_HG-U133A

ESR1 TWF2 SP110 MBNL2 SURF1 CST6

3.33e-0419810667034_DN
DrugAld1.1-H_000455; Down 200; 10uM; MCF7; HT_HG-U133A

BORCS6 ESR1 RUFY3 FZD1 MBNL2 SMAD5

3.33e-0419810667542_DN
DrugClofilium tosylate [92953-10-1]; Up 200; 7.8uM; PC3; HT_HG-U133A

MBTD1 ESR1 EDNRB MBNL2 FGFR1 KDM7A

3.33e-0419810664492_UP
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; HL60; HT_HG-U133A

FMO5 SP110 MBNL2 ZNF614 VPS13B SMAD5

3.33e-0419810663081_DN
Diseaselymphangioleiomyomatosis (is_marker_for)

ESR1 CPT1A STAT1

8.37e-06121013DOID:3319 (is_marker_for)
Diseasedihomo-linolenoylcarnitine (C20:3n3 or 6) measurement

PDXDC1 CPT1A SLCO1A2

1.09e-05131013EFO_0800547
DiseaseHypophosphatemia

NR1I2 FGFR1

3.47e-0531012C0085682
DiseaseQRS duration, response to sulfonylurea

DOCK9 CNTLN UQCC1

6.56e-05231013EFO_0005055, EFO_0007922
DiseaseMalignant neoplasm of breast

ESR1 CPT1A SP110 PKDREJ STAT1 EDNRB SURF1 DDX18 CST6 ZNF432 UQCC1 FGFR1 VPS13B

7.70e-05107410113C0006142
Diseasebreast carcinoma (is_marker_for)

ESR1 FZD1 FZD2 SMAD2

7.92e-05661014DOID:3459 (is_marker_for)
Diseaseresponse to bronchodilator, response to corticosteroid

ZNF432 ZNF614

1.15e-0451012GO_0031960, GO_0097366
DiseaseAganglionic megacolon

ECE1 EDNRB

1.72e-0461012cv:C0019569
Diseaseglycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

CORIN CERS4

2.41e-0471012EFO_0800551
DiseaseX-18899 measurement

CYP4B1 ACKR4

2.41e-0471012EFO_0800793
Diseasecortical surface area change measurement

SV2B CNTN5

3.20e-0481012EFO_0021503
Diseasephenylacetylglutamine measurement

SV2B SNTB1

7.49e-04121012EFO_0021013
Diseasepulmonary hypertension (implicated_via_orthology)

ECE1 EDNRB FGFR1

8.51e-04541013DOID:6432 (implicated_via_orthology)
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

SMAD5 SMAD9

8.83e-04131012DOID:0050787 (implicated_via_orthology)
Diseaseecosanoids measurement

CYP4B1 ACKR4 SLCO1A2

8.97e-04551013EFO_0020044
DiseaseManganese Poisoning

SLC30A10 HTT

1.03e-03141012C0677050
Diseaseasthma (biomarker_via_orthology)

STAT1 EDNRB PRMT3

1.10e-03591013DOID:2841 (biomarker_via_orthology)
DiseaseAganglionosis, Colonic

ECE1 EDNRB

1.18e-03151012C0085758
DiseaseAganglionosis, Rectosigmoid Colon

ECE1 EDNRB

1.18e-03151012C1257840
Diseaseurolithiasis

HIBADH SLC30A10 VPS13B

1.33e-03631013MONDO_0024647
DiseaseCongenital Intestinal Aganglionosis

ECE1 EDNRB

1.53e-03171012C3661523
Diseasealcoholic hepatitis (biomarker_via_orthology)

CPT1A NLRP3

1.71e-03181012DOID:12351 (biomarker_via_orthology)
Diseasemetabolonic lactone sulfate measurement

SLCO1A2 MYH16

1.91e-03191012EFO_0800659
Diseasetemporal horn of lateral ventricle volume measurement

ROBO2 SDC1 SNTB1

1.96e-03721013EFO_0010333
DiseaseCraniofacial Abnormalities

ECE1 SURF1 FGFR1 SMAD2

2.06e-031561014C0376634
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PDXDC1 HECTD4 CPT1A SNTB1 HTT

2.17e-032641015EFO_0008317, EFO_0020944
Diseasemyocardial infarction (biomarker_via_orthology)

NLRP3 FZD2 SDC1 SMAD2

2.26e-031601014DOID:5844 (biomarker_via_orthology)
Diseasedocosahexaenoic acid to total fatty acids percentage

PDXDC1 CPT1A

2.33e-03211012EFO_0022262
DiseaseJT interval, response to sulfonylurea

STAT1 SNTB1

2.80e-03231012EFO_0007885, EFO_0007922
Diseaseserum alanine aminotransferase measurement

HECTD4 NLRP3 JARID2 LTN1 SUMO3 SUMO2 SLC30A10 SDC1 HTT

2.99e-038691019EFO_0004735
DiseaseCerebral Astrocytoma

ESR1 FGFR1

3.31e-03251012C0750935
DiseaseIntracranial Astrocytoma

ESR1 FGFR1

3.31e-03251012C0750936
DiseaseAstrocytoma

ESR1 FGFR1

3.31e-03251012C0004114
Diseasebreast carcinoma (is_implicated_in)

ESR1 STAT1

3.31e-03251012DOID:3459 (is_implicated_in)
DiseaseGrade I Astrocytoma

ESR1 FGFR1

3.31e-03251012C1704230
DiseaseSubependymal Giant Cell Astrocytoma

ESR1 FGFR1

3.31e-03251012C0205768
DiseaseMixed oligoastrocytoma

ESR1 FGFR1

3.31e-03251012C0547065
DiseasePilocytic Astrocytoma

ESR1 FGFR1

3.31e-03251012C0334583
DiseaseJuvenile Pilocytic Astrocytoma

ESR1 FGFR1

3.31e-03251012C0280783
DiseaseDiffuse Astrocytoma

ESR1 FGFR1

3.31e-03251012C0280785
DiseaseChildhood Cerebral Astrocytoma

ESR1 FGFR1

3.31e-03251012C0338070

Protein segments in the cluster

PeptideGeneStartEntry
CRDMFSKMATYLTGE

BLOC1S2

41

Q6QNY1
KMMESYIAVLTKGIC

DENND10P1

121

Q6NSW5
CLILRMLYSFMKKGQ

CERS4

321

Q9HA82
CLKYLVLANMLMKSG

COPS2

276

P61201
TMKVRSGRYDCKTTM

CNTLN

811

Q9NXG0
VESVMKLCLIMAKYS

AKAP4

701

Q5JQC9
DMGKFCLTYEASMTR

CPT1A

581

P50416
FFYTLMTCEMLRKKS

EDNRB

291

P24530
KMYKSGYNTMEKCIE

ANKRD36

1701

A6QL64
CSSAKTILKYMTDGM

DHX15

226

O43143
MKTLTLSRYICEMTL

CCNB3

1276

Q8WWL7
KLMLFLSVTMCLSEY

CNTN5

6

O94779
EFEKCLTMRDTMKYV

SLC25A16

276

P16260
AMLKPMCETLTYISK

LTN1

1341

O94822
MGVCYFITARTLMKM

ACKR4

216

Q9NPB9
SVEMLRCRTASYMKK

OTUD6A

166

Q7L8S5
GMQLRCYEMEKRLKT

KDM7A

376

Q6ZMT4
MCGMVGVRDAFYSKT

MBTD1

56

Q05BQ5
KIFSICVMLIGSLMY

KCNH7

641

Q9NS40
AGRFCMLKKEYMESF

CWC22

511

Q9HCG8
KGSMAMESAKETRYC

ESR1

171

P03372
EMIYSMCKKVLTGVA

IPO7

716

O95373
EYKSMKSCLYVGMAS

PDXDC1

566

Q6P996
GTKKEGCTILFMMLY

FZD2

321

Q14332
FVQYKIMFSCSMKSS

IL22RA2

61

Q969J5
MSTYMFKGIISFAKV

NR1I2

246

O75469
KKLMVFFSSCMSVKY

DDX18

426

Q9NVP1
SRYIRVETCMFMIKL

HECTD4

3956

Q9Y4D8
LCFYKTAKDCVMMFT

ITGB5

681

P18084
GTKKEGCTILFMMLY

FZD1

396

Q9UP38
FMLKYFMCLVVGITS

FZD8

586

Q9H461
ACTFISGMMYLILRK

EMP2

151

P54851
DFKMCYKLTSVVMEK

CDC16

246

Q13042
YLKSCFSREPMMATV

HTT

1296

P42858
LMLTCMYTGKEKVSP

HTT

2921

P42858
AKEVCPMYFMKLRSG

IL33

36

O95760
VDMSIKGMYTLLARC

BORCS6

311

Q96GS4
KRCFTFMDRGYVFKM

DOCK10

1061

Q96BY6
KYGDMRVTMGCEIFS

DOCK4

1036

Q8N1I0
KSLLMCFLYILKSMS

DOCK9

1301

Q9BZ29
VYGFKMSCMKKAVIP

PRMT3

386

O60678
VKMRFYKDFLCTMDG

CCDC81

161

Q6ZN84
LISCMVGSVIVYKMK

FGFR1

386

P11362
YKSVIINTSKEMMCF

FMO5

56

P49326
DLTMVRKIGCYAAMK

GAN

406

Q9H2C0
ATSYIMCLMKFVKGL

ARFGEF3

1351

Q5TH69
FVKMMALRAKCQGYV

COL6A5

2096

A8TX70
LATMCGGKMLDKLRY

DTNB

136

O60941
QSYFDMKTITTRMIC

CORIN

956

Q9Y5Q5
MKTITTRMICAGYES

CORIN

961

Q9Y5Q5
RMCYLTIKEMATISE

COPG2

86

Q9UBF2
FIKYCTMTEKAKIMS

DNAH14

686

Q0VDD8
TVCMDYIKGRCMREK

MBNL2

216

Q5VZF2
LCMYAKETVGFGMLK

LAMTOR2

91

Q9Y2Q5
KYFLTMEMGSTDCRK

CST6

86

Q15828
GKMTYLTMCIKESFR

CYP4B1

361

P13584
KFMEVMYGTKKTCLP

ECE1

416

P42892
TKRKCETSNMMEYVI

CHIC1

196

Q5VXU3
KMMESYIAVLTKGIC

DENND10

121

Q8TCE6
RSATICLAYLMMKKR

DUSP4

286

Q13115
SLKRIAVGMFFVMCS

SLC15A4

401

Q8N697
PTICMAYLMKTKQFR

DUSP5

271

Q16690
LKMNRCLKYATMAFG

FPGT

471

O14772
TVIKYMTDGMLLREC

DHX8

656

Q14562
YRTARNIMSMCFSKE

JARID2

826

Q92833
RRETVKSALMVMYSC

MROH2A

771

A6NES4
MKMASTRCKLARYLE

NLRP3

1

Q96P20
AAMETIYLCKFRVSM

RUFY3

21

Q7L099
MESCELITYLGAKMT

AK9

1866

Q5TCS8
ALISYAVMQISMCKK

SNX4

421

O95219
RKSIPLKMCYVTRSM

SNTB1

241

Q13884
MSMIIYSCLKEERKI

STAT1

101

P42224
VTFSKLMRRMCGFYS

TDRD6

511

O60522
LMRRMCGFYSSASKL

TDRD6

516

O60522
YTDTKMILFMVSGIC

SLAMF6

221

Q96DU3
CLSSSKKGMLGMIVY

SV2B

141

Q7L1I2
EVCSKMFYRKDVMLD

PRDM15

856

P57071
EAMTYLCRKLRTMFS

PKDREJ

2191

Q9NTG1
CRTLMFLKLMATYSA

GNRHR2

26

Q96P88
TKDMRKSQERSMSYC

nan

126

Q6P435
FAVCLVGFMLYRMKK

SDC1

266

P18827
EKCMSMRKSYPNTLR

TEKT3

471

Q9BXF9
KVRGCFDHSKELYMM

SURF1

121

Q15526
GYMVLLRCMKSEEKS

SLCO1A2

531

P46721
SIITKRMYMESLEAC

SP110

41

Q9HB58
KCRLQTMYEMETSGK

SLC25A15

131

Q9Y619
MSKTLCIRMTTGAFK

OR5K4

136

A6NMS3
YELTKMCTIRMSFVK

SMAD9

406

O15198
EAVYELTKMCTIRMS

SMAD5

401

Q99717
RMMCAKGYSKKDFSS

HIBADH

311

P31937
KLMKAYCERQGLSMR

SUMO3

41

P55854
MGRYSGKTCRLLFML

SLC30A10

1

Q6XR72
YQLTRMCTIRMSFVK

SMAD2

406

Q15796
SKLMKAYCERQGLSM

SUMO2

41

P61956
KKTMSTDEGTYMCIA

ROBO2

281

Q9HCK4
MCLVRMKQEGRSGKY

UQCC1

156

Q9NVA1
MKQEGRSGKYMCRII

UQCC1

161

Q9NVA1
KGKVMASMFYEVSTR

CAD

1961

P27708
ECRMYMTESFKIKTA

MYH16

636

Q9H6N6
MVKKMCQDYLSSSGL

ZNF839

411

A8K0R7
ISLMTYSCMALSKSK

VPS13B

1846

Q7Z7G8
FMCSECGKGFTMKRY

ZNF432

541

O94892
EIRGTLKMMCESFIY

UGT2A3

116

Q6UWM9
SYMCSECGKGFTMKR

ZNF614

286

Q8N883
RLCIDLSMTHYMSKK

TRMT10B

126

Q6PF06
LKSNTEKFYMLCLMT

POLR1B

336

Q9H9Y6
EKFYMLCLMTRKLFA

POLR1B

341

Q9H9Y6
KKLLMMAGIDDCYTS

RPS2

211

P15880
SLMKEARKMVSRCTY

PPP1R10

36

Q96QC0
IYSMPGYKCSIKERM

TWF2

256

Q6IBS0
GQMVKLKYCFTCKMF

ZDHHC18

186

Q9NUE0
MKKYRKISIGCFAMA

VWA3A

1

A6NCI4