Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	neuroligin family protein binding	NRXN3 NRXN1	1.76e-05	5	27	2	GO:0097109
GeneOntologyMolecularFunction	Notch binding	JAG1 NOTCH4	6.05e-04	27	27	2	GO:0005112
GeneOntologyBiologicalProcess	cell-cell adhesion	SLIT2 NRXN3 IGFBP2 NRXN1 TEK SVEP1 JAG1 NOTCH4 LIMS2	5.57e-06	1077	27	9	GO:0098609
GeneOntologyBiologicalProcess	Tie signaling pathway	TEK SVEP1	1.65e-05	5	27	2	GO:0048014
GeneOntologyBiologicalProcess	vasculature development	SLIT2 NRXN3 NRXN1 TEK ADAMTS6 SVEP1 JAG1 NOTCH4	2.30e-05	969	27	8	GO:0001944
GeneOntologyBiologicalProcess	negative regulation of plasma membrane bounded cell projection assembly	SLIT2 NRXN1 LPAR1	2.74e-05	45	27	3	GO:0120033
GeneOntologyBiologicalProcess	regulation of smooth muscle cell chemotaxis	SLIT2 LPAR1	5.91e-05	9	27	2	GO:0071671
GeneOntologyBiologicalProcess	smooth muscle cell chemotaxis	SLIT2 LPAR1	9.01e-05	11	27	2	GO:0071670
GeneOntologyBiologicalProcess	adult behavior	PRKN ADAM2 NRXN3 NRXN1	1.34e-04	203	27	4	GO:0030534
GeneOntologyBiologicalProcess	blood vessel development	SLIT2 NRXN3 NRXN1 TEK ADAMTS6 JAG1 NOTCH4	1.48e-04	929	27	7	GO:0001568
GeneOntologyBiologicalProcess	aorta development	ADAMTS6 JAG1 NOTCH4	1.54e-04	80	27	3	GO:0035904
GeneOntologyBiologicalProcess	cardiac chamber development	SLIT2 TEK ADAMTS6 JAG1	1.58e-04	212	27	4	GO:0003205
GeneOntologyBiologicalProcess	learning	PRKN ADAM2 NRXN3 NRXN1	1.58e-04	212	27	4	GO:0007612
GeneOntologyBiologicalProcess	negative regulation of endothelial cell differentiation	JAG1 NOTCH4	1.71e-04	15	27	2	GO:0045602
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	NRXN3 NRXN1	1.96e-04	16	27	2	GO:0007158
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	SLIT2 TEK HOXB13 NOTCH4	2.38e-04	236	27	4	GO:0061138
GeneOntologyBiologicalProcess	angiogenesis	SLIT2 NRXN3 NRXN1 TEK JAG1 NOTCH4	2.56e-04	708	27	6	GO:0001525
GeneOntologyBiologicalProcess	regulation of synaptic vesicle cycle	NRXN1 LPAR1	2.78e-04	19	27	2	GO:0098693
GeneOntologyBiologicalProcess	pulmonary valve morphogenesis	SLIT2 JAG1	3.09e-04	20	27	2	GO:0003184
GeneOntologyBiologicalProcess	morphogenesis of a branching structure	SLIT2 TEK HOXB13 NOTCH4	3.35e-04	258	27	4	GO:0001763
GeneOntologyBiologicalProcess	circulatory system development	SLIT2 NRXN3 NRXN1 TEK ADAMTS6 SVEP1 JAG1 NOTCH4	3.74e-04	1442	27	8	GO:0072359
GeneOntologyBiologicalProcess	pulmonary valve development	SLIT2 JAG1	4.47e-04	24	27	2	GO:0003177
GeneOntologyBiologicalProcess	vocalization behavior	NRXN3 NRXN1	4.47e-04	24	27	2	GO:0071625
GeneOntologyBiologicalProcess	trans-synaptic signaling, modulating synaptic transmission	NRXN3 NRXN1	5.26e-04	26	27	2	GO:0099550
GeneOntologyBiologicalProcess	blood vessel morphogenesis	SLIT2 NRXN3 NRXN1 TEK JAG1 NOTCH4	5.50e-04	817	27	6	GO:0048514
GeneOntologyBiologicalProcess	artery development	ADAMTS6 JAG1 NOTCH4	6.85e-04	133	27	3	GO:0060840
GeneOntologyBiologicalProcess	cardiac septum development	SLIT2 ADAMTS6 JAG1	7.00e-04	134	27	3	GO:0003279
GeneOntologyBiologicalProcess	positive regulation of cell junction assembly	SLIT2 NRXN1 TEK	7.30e-04	136	27	3	GO:1901890
GeneOntologyBiologicalProcess	postsynaptic density assembly	NRXN3 NRXN1	9.02e-04	34	27	2	GO:0097107
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	SLIT2 TEK HOXB13 JAG1 NOTCH4	1.12e-03	619	27	5	GO:0002009
GeneOntologyBiologicalProcess	aortic valve morphogenesis	SLIT2 JAG1	1.19e-03	39	27	2	GO:0003180
GeneOntologyBiologicalProcess	cardiac chamber morphogenesis	SLIT2 TEK JAG1	1.19e-03	161	27	3	GO:0003206
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane neurotransmitter receptor levels	PRKN NRXN3 LPAR1	1.25e-03	164	27	3	GO:0099072
GeneOntologyBiologicalProcess	startle response	PRKN NRXN1	1.31e-03	41	27	2	GO:0001964
GeneOntologyBiologicalProcess	positive regulation of Rho protein signal transduction	TEK LPAR1	1.31e-03	41	27	2	GO:0035025
GeneOntologyBiologicalProcess	aorta morphogenesis	JAG1 NOTCH4	1.31e-03	41	27	2	GO:0035909
GeneOntologyBiologicalProcess	kidney development	SLIT2 TEK ADAMTS6 JAG1	1.32e-03	372	27	4	GO:0001822
GeneOntologyBiologicalProcess	learning or memory	PRKN ADAM2 NRXN3 NRXN1	1.33e-03	373	27	4	GO:0007611
GeneOntologyBiologicalProcess	cell junction organization	SLIT2 NRXN3 NRXN1 TEK SVEP1 LIMS2	1.38e-03	974	27	6	GO:0034330
GeneOntologyBiologicalProcess	renal system development	SLIT2 TEK ADAMTS6 JAG1	1.51e-03	386	27	4	GO:0072001
GeneOntologyBiologicalProcess	postsynaptic specialization assembly	NRXN3 NRXN1	1.51e-03	44	27	2	GO:0098698
GeneOntologyBiologicalProcess	gland morphogenesis	SLIT2 HOXB13 LIMS2	1.59e-03	178	27	3	GO:0022612
GeneOntologyBiologicalProcess	aortic valve development	SLIT2 JAG1	1.65e-03	46	27	2	GO:0003176
GeneOntologyBiologicalProcess	excitatory synapse assembly	NRXN3 NRXN1	1.65e-03	46	27	2	GO:1904861
GeneOntologyBiologicalProcess	branching involved in blood vessel morphogenesis	TEK NOTCH4	1.72e-03	47	27	2	GO:0001569
GeneOntologyBiologicalProcess	cell-substrate adhesion	TEK SVEP1 JAG1 LIMS2	1.88e-03	410	27	4	GO:0031589
GeneOntologyBiologicalProcess	cell fate determination	JAG1 NOTCH4	1.94e-03	50	27	2	GO:0001709
GeneOntologyBiologicalProcess	semi-lunar valve development	SLIT2 JAG1	1.94e-03	50	27	2	GO:1905314
GeneOntologyBiologicalProcess	signal release from synapse	PRKN NRXN3 NRXN1	2.06e-03	195	27	3	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	PRKN NRXN3 NRXN1	2.06e-03	195	27	3	GO:0007269
GeneOntologyBiologicalProcess	cognition	PRKN ADAM2 NRXN3 NRXN1	2.11e-03	423	27	4	GO:0050890
GeneOntologyBiologicalProcess	branching morphogenesis of an epithelial tube	SLIT2 TEK NOTCH4	2.15e-03	198	27	3	GO:0048754
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	SLIT2 PRKN TEK LPAR1 JAG1 NOTCH4	2.44e-03	1090	27	6	GO:0022603
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine kinase signaling pathway	MST1R IGFBP2 NRXN1 TEK SVEP1	2.56e-03	747	27	5	GO:0007169
GeneOntologyBiologicalProcess	tissue morphogenesis	SLIT2 TEK HOXB13 JAG1 NOTCH4	2.60e-03	750	27	5	GO:0048729
GeneOntologyBiologicalProcess	postsynaptic density organization	NRXN3 NRXN1	2.61e-03	58	27	2	GO:0097106
GeneOntologyCellularComponent	cell surface	MST1R SLIT2 ADAM2 NRXN1 TEK VWDE LPAR1 NOTCH4	4.11e-05	1111	26	8	GO:0009986
Domain	EGF_3	SLIT2 ADAM2 NRXN3 NRXN1 TEK VWDE SVEP1 JAG1 NOTCH4	2.61e-11	235	27	9	PS50026
Domain	EGF_1	SLIT2 ADAM2 NRXN3 NRXN1 TEK VWDE SVEP1 JAG1 NOTCH4	5.42e-11	255	27	9	PS00022
Domain	EGF_2	SLIT2 ADAM2 NRXN3 NRXN1 TEK VWDE SVEP1 JAG1 NOTCH4	7.63e-11	265	27	9	PS01186
Domain	EGF	SLIT2 NRXN3 NRXN1 TEK VWDE SVEP1 JAG1 NOTCH4	1.01e-09	235	27	8	SM00181
Domain	EGF-like_dom	SLIT2 NRXN3 NRXN1 TEK VWDE SVEP1 JAG1 NOTCH4	1.59e-09	249	27	8	IPR000742
Domain	EGF-like_CS	SLIT2 NRXN3 NRXN1 TEK VWDE SVEP1 JAG1 NOTCH4	2.31e-09	261	27	8	IPR013032
Domain	ASX_HYDROXYL	SLIT2 NRXN3 NRXN1 SVEP1 JAG1 NOTCH4	5.47e-09	100	27	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	SLIT2 NRXN3 NRXN1 SVEP1 JAG1 NOTCH4	7.78e-09	106	27	6	IPR000152
Domain	EGF	SLIT2 NRXN3 NRXN1 SVEP1 JAG1 NOTCH4	2.20e-08	126	27	6	PF00008
Domain	hEGF	SLIT2 SVEP1 JAG1 NOTCH4	6.92e-08	28	27	4	PF12661
Domain	Growth_fac_rcpt_	IGFBP2 TEK SVEP1 JAG1 NOTCH4	2.65e-06	156	27	5	IPR009030
Domain	-	SLIT2 NRXN3 NRXN1 SVEP1	1.01e-05	95	27	4	2.60.120.200
Domain	EGF_Ca-bd_CS	SLIT2 SVEP1 JAG1 NOTCH4	1.09e-05	97	27	4	IPR018097
Domain	EGF_CA	SLIT2 SVEP1 JAG1 NOTCH4	1.19e-05	99	27	4	PS01187
Domain	LAM_G_DOMAIN	SLIT2 NRXN3 NRXN1	2.20e-05	38	27	3	PS50025
Domain	Laminin_G_2	SLIT2 NRXN3 NRXN1	2.57e-05	40	27	3	PF02210
Domain	EGF_CA	SLIT2 SVEP1 JAG1 NOTCH4	2.71e-05	122	27	4	SM00179
Domain	EGF-like_Ca-bd_dom	SLIT2 SVEP1 JAG1 NOTCH4	2.89e-05	124	27	4	IPR001881
Domain	LamG	SLIT2 NRXN3 NRXN1	3.43e-05	44	27	3	SM00282
Domain	Syndecan	NRXN3 NRXN1	4.21e-05	7	27	2	PF01034
Domain	Syndecan/Neurexin_dom	NRXN3 NRXN1	4.21e-05	7	27	2	IPR027789
Domain	Laminin_G	SLIT2 NRXN3 NRXN1	7.88e-05	58	27	3	IPR001791
Domain	EGF_extracell	TEK SVEP1 JAG1	8.73e-05	60	27	3	IPR013111
Domain	EGF_2	TEK SVEP1 JAG1	8.73e-05	60	27	3	PF07974
Domain	Ephrin_rec_like	SVEP1 TG	1.10e-04	11	27	2	PF07699
Domain	Neurexin-like	NRXN3 NRXN1	1.81e-04	14	27	2	IPR003585
Domain	4.1m	NRXN3 NRXN1	1.81e-04	14	27	2	SM00294
Domain	EGF_CA	SVEP1 JAG1 NOTCH4	2.55e-04	86	27	3	PF07645
Domain	ConA-like_dom	SLIT2 NRXN3 NRXN1 SVEP1	2.61e-04	219	27	4	IPR013320
Domain	Thyroglobulin_1	IGFBP2 TG	2.70e-04	17	27	2	PF00086
Domain	TY	IGFBP2 TG	2.70e-04	17	27	2	SM00211
Domain	-	IGFBP2 TG	2.70e-04	17	27	2	4.10.800.10
Domain	THYROGLOBULIN_1_1	IGFBP2 TG	2.70e-04	17	27	2	PS00484
Domain	THYROGLOBULIN_1_2	IGFBP2 TG	2.70e-04	17	27	2	PS51162
Domain	Thyroglobulin_1	IGFBP2 TG	2.70e-04	17	27	2	IPR000716
Domain	Ephrin_rec_like	SVEP1 TG	5.92e-04	25	27	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	SVEP1 TG	5.92e-04	25	27	2	IPR011641
Domain	Peptidase_M12B_N	ADAM2 ADAMTS6	1.44e-03	39	27	2	IPR002870
Domain	Pep_M12B_propep	ADAM2 ADAMTS6	1.44e-03	39	27	2	PF01562
Domain	DISINTEGRIN_1	ADAM2 ADAMTS6	1.52e-03	40	27	2	PS00427
Domain	ADAM_MEPRO	ADAM2 ADAMTS6	1.52e-03	40	27	2	PS50215
Domain	DISINTEGRIN_2	ADAM2 ADAMTS6	1.52e-03	40	27	2	PS50214
Domain	LDLR_class-A_CS	LDLRAD3 MFRP	1.52e-03	40	27	2	IPR023415
Domain	Reprolysin	ADAM2 ADAMTS6	1.52e-03	40	27	2	PF01421
Domain	Peptidase_M12B	ADAM2 ADAMTS6	1.52e-03	40	27	2	IPR001590
Domain	Disintegrin_dom	ADAM2 ADAMTS6	1.59e-03	41	27	2	IPR001762
Domain	Ldl_recept_a	LDLRAD3 MFRP	1.92e-03	45	27	2	PF00057
Domain	-	LDLRAD3 MFRP	2.00e-03	46	27	2	4.10.400.10
Domain	LDLRA_1	LDLRAD3 MFRP	2.18e-03	48	27	2	PS01209
Domain	LDrepeatLR_classA_rpt	LDLRAD3 MFRP	2.27e-03	49	27	2	IPR002172
Domain	LDLa	LDLRAD3 MFRP	2.27e-03	49	27	2	SM00192
Domain	LDLRA_2	LDLRAD3 MFRP	2.27e-03	49	27	2	PS50068
Domain	TSP_1	CFP ADAMTS6	3.72e-03	63	27	2	PF00090
Domain	Zinc_finger_PHD-type_CS	PHF20 NSD3	3.96e-03	65	27	2	IPR019786
Domain	TSP1	CFP ADAMTS6	3.96e-03	65	27	2	SM00209
Domain	TSP1_rpt	CFP ADAMTS6	3.96e-03	65	27	2	IPR000884
Domain	TSP1	CFP ADAMTS6	3.96e-03	65	27	2	PS50092
Domain	PHD	PHF20 NSD3	5.23e-03	75	27	2	PF00628
Domain	Znf_PHD-finger	PHF20 NSD3	5.79e-03	79	27	2	IPR019787
Domain	MetalloPept_cat_dom	ADAM2 ADAMTS6	6.08e-03	81	27	2	IPR024079
Domain	-	ADAM2 ADAMTS6	6.08e-03	81	27	2	3.40.390.10
Domain	TyrKc	MST1R TEK	7.14e-03	88	27	2	SM00219
Domain	Tyr_kinase_cat_dom	MST1R TEK	7.14e-03	88	27	2	IPR020635
Pathway	REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	JAG1 NOTCH4	1.15e-04	11	21	2	M27882
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	CFP ADAMTS6 NOTCH4	1.34e-04	68	21	3	M27303
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	JAG1 NOTCH4	1.38e-04	12	21	2	M47532
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	JAG1 NOTCH4	1.63e-04	13	21	2	M47423
Pathway	KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY	JAG1 NOTCH4	2.50e-04	16	21	2	M47424
Pathway	WP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION	LPAR1 JAG1	2.84e-04	17	21	2	M39389
Pathway	WP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS	NRXN3 NRXN1	7.25e-04	27	21	2	M45550
Pathway	WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING	JAG1 NOTCH4	7.25e-04	27	21	2	M39545
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NRXN3 NRXN1	1.02e-03	32	21	2	MM15326
Pathway	WP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV	NRXN3 NRXN1	1.09e-03	33	21	2	M39875
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	CFP ADAMTS6 NOTCH4	1.19e-03	143	21	3	M27275
Pathway	WP_NEOVASCULARIZATION_PROCESSES	JAG1 NOTCH4	1.36e-03	37	21	2	M39506
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	CFP ADAMTS6	1.52e-03	39	21	2	M27417
Pathway	REACTOME_SIGNALING_BY_NOTCH	JAG1 NOTCH4	1.52e-03	39	21	2	MM14604
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	CFP ADAMTS6	1.52e-03	39	21	2	MM15165
Pathway	WP_NOTCH_SIGNALING_WP268	JAG1 NOTCH4	2.01e-03	45	21	2	M39571
Pathway	WP_NOTCH_SIGNALING_PATHWAY	JAG1 NOTCH4	2.10e-03	46	21	2	MM15971
Pathway	REACTOME_KIDNEY_DEVELOPMENT	SLIT2 JAG1	2.10e-03	46	21	2	M48243
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	JAG1 NOTCH4	2.19e-03	47	21	2	M7946
Pubmed	Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.	TEK JAG1 NOTCH4	1.46e-08	7	27	3	11344305
Pubmed	PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.	NRXN3 NRXN1 JAG1	3.49e-08	9	27	3	9707552
Pubmed	GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.	SLIT2 TEK JAG1 NOTCH4	1.27e-07	59	27	4	21421844
Pubmed	The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.	TEK JAG1 NOTCH4	4.01e-07	19	27	3	20627076
Pubmed	Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study.	NRXN3 NRXN1	5.80e-07	2	27	2	19658047
Pubmed	JAG1-NOTCH4 mechanosensing drives atherosclerosis.	JAG1 NOTCH4	5.80e-07	2	27	2	36044575
Pubmed	Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.	NRXN3 NRXN1	5.80e-07	2	27	2	37543682
Pubmed	Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.	NRXN3 NRXN1	5.80e-07	2	27	2	9430716
Pubmed	Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.	JAG1 NOTCH4	5.80e-07	2	27	2	26387946
Pubmed	SVEP1 as a Genetic Modifier of TEK-Related Primary Congenital Glaucoma.	TEK SVEP1	5.80e-07	2	27	2	33027505
Pubmed	Loss of Gata5 in mice leads to bicuspid aortic valve.	TEK JAG1 NOTCH4	8.35e-07	24	27	3	21633169
Pubmed	Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.	NRXN3 NRXN1	1.74e-06	3	27	2	34133920
Pubmed	Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.	NRXN3 NRXN1	1.74e-06	3	27	2	38891114
Pubmed	Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.	NRXN3 NRXN1	1.74e-06	3	27	2	12036300
Pubmed	β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.	NRXN3 NRXN1	1.74e-06	3	27	2	26213384
Pubmed	Neurexin gene family variants as risk factors for autism spectrum disorder.	NRXN3 NRXN1	1.74e-06	3	27	2	29045040
Pubmed	Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.	NRXN3 NRXN1	1.74e-06	3	27	2	31005376
Pubmed	Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.	JAG1 NOTCH4	1.74e-06	3	27	2	15939383
Pubmed	Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.	NRXN3 NRXN1	1.74e-06	3	27	2	38571813
Pubmed	Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.	NRXN3 NRXN1	1.74e-06	3	27	2	35173587
Pubmed	The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.	NRXN3 NRXN1	1.74e-06	3	27	2	30858964
Pubmed	Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma.	JAG1 NOTCH4	1.74e-06	3	27	2	26341090
Pubmed	Neurexins are differentially expressed in the embryonic nervous system of mice.	NRXN3 NRXN1	1.74e-06	3	27	2	7722633
Pubmed	Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.	NRXN3 NRXN1	1.74e-06	3	27	2	26446217
Pubmed	Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.	NRXN3 NRXN1	1.74e-06	3	27	2	28013231
Pubmed	Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.	NRXN3 NRXN1	1.74e-06	3	27	2	11944992
Pubmed	alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.	NRXN3 NRXN1	1.74e-06	3	27	2	16406382
Pubmed	Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.	NRXN3 NRXN1	1.74e-06	3	27	2	33058888
Pubmed	Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.	NRXN3 NRXN1	1.74e-06	3	27	2	17035546
Pubmed	Neurexins: three genes and 1001 products.	NRXN3 NRXN1	1.74e-06	3	27	2	9448462
Pubmed	Deletion of α-neurexin II results in autism-related behaviors in mice.	NRXN3 NRXN1	1.74e-06	3	27	2	25423136
Pubmed	Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.	NRXN3 NRXN1	1.74e-06	3	27	2	31812984
Pubmed	Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.	JAG1 NOTCH4	1.74e-06	3	27	2	14988227
Pubmed	Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.	NRXN3 NRXN1	3.48e-06	4	27	2	14983056
Pubmed	CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.	NRXN3 NRXN1	3.48e-06	4	27	2	8786425
Pubmed	Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.	NRXN3 NRXN1	3.48e-06	4	27	2	17347997
Pubmed	Neurexins cluster Ca2+ channels within the presynaptic active zone.	NRXN3 NRXN1	3.48e-06	4	27	2	32134527
Pubmed	Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.	NRXN3 NRXN1	3.48e-06	4	27	2	32706374
Pubmed	Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.	JAG1 NOTCH4	3.48e-06	4	27	2	17984306
Pubmed	Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.	NRXN3 NRXN1	3.48e-06	4	27	2	35385735
Pubmed	Neurexins regulate presynaptic GABAB-receptors at central synapses.	NRXN3 NRXN1	3.48e-06	4	27	2	33888718
Pubmed	Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.	JAG1 NOTCH4	3.48e-06	4	27	2	36376768
Pubmed	Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.	NRXN3 NRXN1	5.80e-06	5	27	2	28472659
Pubmed	Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.	NRXN3 NRXN1	5.80e-06	5	27	2	36709330
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NRXN3 NRXN1	5.80e-06	5	27	2	18923512
Pubmed	Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.	JAG1 NOTCH4	5.80e-06	5	27	2	15882997
Pubmed	Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.	NRXN3 NRXN1	5.80e-06	5	27	2	20537373
Pubmed	Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.	JAG1 NOTCH4	5.80e-06	5	27	2	27118257
Pubmed	Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner.	NRXN3 NRXN1	5.80e-06	5	27	2	36205393
Pubmed	Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.	JAG1 NOTCH4	5.80e-06	5	27	2	21602525
Pubmed	Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.	NRXN3 NRXN1	5.80e-06	5	27	2	9223334
Pubmed	Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.	JAG1 NOTCH4	5.80e-06	5	27	2	20554499
Pubmed	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.	TEK JAG1 NOTCH4	7.05e-06	48	27	3	28924218
Pubmed	A study on Notch signaling in human breast cancer.	JAG1 NOTCH4	8.69e-06	6	27	2	17822320
Pubmed	Structures, alternative splicing, and neurexin binding of multiple neuroligins.	NRXN3 NRXN1	8.69e-06	6	27	2	8576240
Pubmed	Characterization of Notch receptor expression in the developing mammalian heart and liver.	JAG1 NOTCH4	8.69e-06	6	27	2	12244553
Pubmed	Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.	NRXN3 NRXN1	8.69e-06	6	27	2	30683685
Pubmed	Notch4 reveals a novel mechanism regulating Notch signal transduction.	JAG1 NOTCH4	8.69e-06	6	27	2	24667410
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	NRXN3 NRXN1	8.69e-06	6	27	2	12827191
Pubmed	A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles.	JAG1 NOTCH4	8.69e-06	6	27	2	29627423
Pubmed	Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.	NRXN3 NRXN1	8.69e-06	6	27	2	19816407
Pubmed	Human ligands of the Notch receptor.	JAG1 NOTCH4	1.22e-05	7	27	2	10079256
Pubmed	Glycosylation of Cblns attenuates their receptor binding.	NRXN3 NRXN1	1.22e-05	7	27	2	29782851
Pubmed	Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.	NRXN3 NRXN1	1.22e-05	7	27	2	9856994
Pubmed	The distribution of Notch receptors and their ligands during articular cartilage development.	JAG1 NOTCH4	1.22e-05	7	27	2	12846471
Pubmed	Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney.	TEK NOTCH4	1.62e-05	8	27	2	16546160
Pubmed	GluD1 is a signal transduction device disguised as an ionotropic receptor.	NRXN3 NRXN1	1.62e-05	8	27	2	34135511
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NRXN3 NRXN1	1.62e-05	8	27	2	30871858
Pubmed	Notch1 and Jagged1 expression by the developing pulmonary vasculature.	JAG1 NOTCH4	1.62e-05	8	27	2	12242716
Pubmed	Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.	JAG1 NOTCH4	1.62e-05	8	27	2	9858718
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	NRXN3 NRXN1	1.62e-05	8	27	2	37591863
Pubmed	Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.	JAG1 NOTCH4	1.62e-05	8	27	2	22156581
Pubmed	Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.	JAG1 NOTCH4	2.08e-05	9	27	2	11118901
Pubmed	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.	JAG1 NOTCH4	2.08e-05	9	27	2	16245338
Pubmed	Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad.	JAG1 NOTCH4	2.08e-05	9	27	2	11944948
Pubmed	Molecular self-avoidance in synaptic neurexin complexes.	NRXN3 NRXN1	2.08e-05	9	27	2	34919427
Pubmed	Notch signaling is essential for vascular morphogenesis in mice.	JAG1 NOTCH4	2.08e-05	9	27	2	10837027
Pubmed	Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.	JAG1 NOTCH4	2.60e-05	10	27	2	23665443
Pubmed	Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.	SLIT2 NOTCH4	2.60e-05	10	27	2	17496152
Pubmed	Unique functions for Notch4 in murine embryonic lymphangiogenesis.	JAG1 NOTCH4	2.60e-05	10	27	2	34665379
Pubmed	Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.	JAG1 NOTCH4	3.18e-05	11	27	2	10878608
Pubmed	The expression of Sox17 identifies and regulates haemogenic endothelium.	JAG1 NOTCH4	3.18e-05	11	27	2	23604320
Pubmed	Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.	TEK JAG1	3.18e-05	11	27	2	15875024
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NRXN3 NRXN1	3.18e-05	11	27	2	32973045
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	JAG1 NOTCH4	3.18e-05	11	27	2	15499562
Pubmed	A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.	JAG1 NOTCH4	3.18e-05	11	27	2	9187150
Pubmed	Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.	JAG1 NOTCH4	3.18e-05	11	27	2	12866128
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	JAG1 NOTCH4	3.81e-05	12	27	2	15465494
Pubmed	Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary.	TEK JAG1	3.81e-05	12	27	2	35337816
Pubmed	Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.	JAG1 NOTCH4	3.81e-05	12	27	2	36082581
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	SLIT2 IGFBP2 MFRP SVEP1	3.89e-05	248	27	4	24006456
Pubmed	Notch signaling is required for the maintenance of enteric neural crest progenitors.	JAG1 NOTCH4	4.50e-05	13	27	2	18832397
Pubmed	Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.	JAG1 NOTCH4	4.50e-05	13	27	2	11578869
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	JAG1 NOTCH4	4.50e-05	13	27	2	20558824
Pubmed	Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.	JAG1 NOTCH4	5.25e-05	14	27	2	28192800
Pubmed	Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.	JAG1 NOTCH4	5.25e-05	14	27	2	18528438
Pubmed	Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.	JAG1 NOTCH4	5.25e-05	14	27	2	21402699
Pubmed	The contribution of rare and common variants in 30 genes to risk nicotine dependence.	NRXN3 NRXN1	5.25e-05	14	27	2	25450229
Pubmed	Expression of insulin-like growth factor binding proteins during mouse cochlear development.	IGFBP2 JAG1	5.25e-05	14	27	2	23813480
Pubmed	Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.	JAG1 NOTCH4	5.25e-05	14	27	2	14757642
Cytoband	8p11.2	ADAM2 NSD3	3.02e-05	14	27	2	8p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr8p11	ADAM2 NSD3	1.69e-03	103	27	2	chr8p11
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	LPAR1 SVEP1	2.95e-03	137	27	2	chr9q31
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	MST1R TEK	7.97e-04	40	19	2	321
GeneFamily	PHD finger proteins	PHF20 NSD3	3.97e-03	90	19	2	88
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MST1R TEK JAG1	7.68e-03	394	19	3	471
Coexpression	NABA_MATRISOME	SLIT2 ADAM2 IGFBP2 MFRP ADAMTS6 VWDE CTSW SVEP1	5.38e-06	1008	27	8	MM17056
Coexpression	NABA_ECM_GLYCOPROTEINS	SLIT2 IGFBP2 VWDE SVEP1	4.21e-05	191	27	4	MM17059
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	SLIT2 NRXN3 NRXN1 NSD3	4.38e-05	193	27	4	M6813
Coexpression	NABA_ECM_GLYCOPROTEINS	SLIT2 IGFBP2 VWDE SVEP1	4.65e-05	196	27	4	M3008
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	SLIT2 NRXN3 NRXN1 NSD3	4.65e-05	196	27	4	MM667
Coexpression	GSE18281_CORTICAL_VS_MEDULLARY_THYMOCYTE_DN	PHF20 ADAMTS6 SVEP1 TG	4.74e-05	197	27	4	M7258
Coexpression	NABA_MATRISOME	SLIT2 ADAM2 IGFBP2 ADAMTS6 VWDE CTSW SVEP1	6.16e-05	1026	27	7	M5889
Coexpression	ROSS_AML_WITH_PML_RARA_FUSION	IGFBP2 CTSW JAG1	7.60e-05	80	27	3	M15368
Coexpression	FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_1	IGFBP2 LDLRAD3 TEK NOTCH4 LIMS2	7.76e-05	440	27	5	M39039
Coexpression	HAY_BONE_MARROW_STROMAL	SLIT2 NRXN3 IGFBP2 NRXN1 SVEP1 JAG1	1.08e-04	767	27	6	M39209
Coexpression	LIM_MAMMARY_STEM_CELL_UP	SLIT2 IGFBP2 SVEP1 JAG1 LIMS2	1.16e-04	479	27	5	M2573
Coexpression	LIM_MAMMARY_STEM_CELL_UP	SLIT2 IGFBP2 SVEP1 JAG1 LIMS2	1.20e-04	483	27	5	MM1082
Coexpression	FUKUSHIMA_TNFSF11_TARGETS	JAG1 NOTCH4	1.22e-04	16	27	2	M2207
Coexpression	FUKUSHIMA_TNFSF11_TARGETS	JAG1 NOTCH4	1.22e-04	16	27	2	MM1296
Coexpression	HE_LIM_SUN_FETAL_LUNG_C7_MID_SCHWANN_CELL	SLIT2 NRXN3 LPAR1 JAG1	1.56e-04	268	27	4	M45796
Coexpression	NABA_CORE_MATRISOME	SLIT2 IGFBP2 VWDE SVEP1	1.60e-04	270	27	4	MM17057
Coexpression	NABA_CORE_MATRISOME	SLIT2 IGFBP2 VWDE SVEP1	1.72e-04	275	27	4	M5884
Coexpression	HEVNER_CORTEX_VASCULAR_ENDOTHELIAL_CELLS	TEK NOTCH4	1.73e-04	19	27	2	MM420
Coexpression	AIZARANI_LIVER_C13_LSECS_2	CFP TEK NOTCH4 LIMS2	1.92e-04	283	27	4	M39117
Coexpression	DURAND_STROMA_S_UP	LPAR1 HOXB13 SVEP1 NOTCH4	2.40e-04	300	27	4	M2581
Coexpression	DURAND_STROMA_S_UP	LPAR1 HOXB13 SVEP1 NOTCH4	2.52e-04	304	27	4	MM1083
Coexpression	CLIMENT_BREAST_CANCER_COPY_NUMBER_UP	JAG1 TG	2.55e-04	23	27	2	M13910
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_MYL4_POS_SMC_CELL	IGFBP2 ADAMTS6 LIMS2	2.78e-04	124	27	3	M45673
Coexpression	LAKE_ADULT_KIDNEY_C20_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_A_CORTEX	SLIT2 PRKN NRXN3	5.05e-04	152	27	3	M39239
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_1000	SLIT2 TEK ADAMTS6 LPAR1 SVEP1	1.75e-05	261	27	5	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_1000
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_top-relative-expression-ranked_1000	SLIT2 NRXN3 NRXN1 TEK ADAMTS6 LPAR1 SVEP1	2.78e-05	734	27	7	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_1000
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.40e-09	189	27	6	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.49e-09	191	27	6	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IGFBP2 TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.68e-09	195	27	6	a432d69b0172211ee4d53675936a1dc9ce1ae1f0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	4.72e-08	165	27	5	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	5.32e-08	169	27	5	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	6.70e-08	177	27	5	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	6.89e-08	178	27	5	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	7.09e-08	179	27	5	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 JAG1 LIMS2	8.58e-08	186	27	5	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	8.81e-08	187	27	5	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	9.05e-08	188	27	5	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	9.29e-08	189	27	5	12b6f1c3bf526b90e112374bf937701f645c5780
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 NOTCH4 LIMS2	9.29e-08	189	27	5	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	9.54e-08	190	27	5	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	9.54e-08	190	27	5	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	9.54e-08	190	27	5	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP2 TEK JAG1 NOTCH4 LIMS2	9.54e-08	190	27	5	ec6b8e2852e1cce0217ff61243defe98b2351640
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	9.79e-08	191	27	5	04c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	9.79e-08	191	27	5	db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.00e-07	192	27	5	bacbaef1f230051335f4433e55db07a161b96b4c
ToppCell	EC\|World / Lineage and Cell class	IGFBP2 TEK JAG1 NOTCH4 LIMS2	1.00e-07	192	27	5	478866dd5b0d6ff3a76d07a17c4b5989dd7a27bb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.03e-07	193	27	5	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.03e-07	193	27	5	3a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.03e-07	193	27	5	cc355b2ed6510619cad969ae074126d7c8db784d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.03e-07	193	27	5	6a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.03e-07	193	27	5	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.03e-07	193	27	5	ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.06e-07	194	27	5	71ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.06e-07	194	27	5	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.06e-07	194	27	5	40842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.06e-07	194	27	5	b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.09e-07	195	27	5	517af3e6784f02c382df6f5691945eefaa9ec4ae
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.09e-07	195	27	5	75db19c0371320ea5fce1d6de8c1b40b1e6a2e58
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.09e-07	195	27	5	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	COVID-19-lung-Capillary_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.11e-07	196	27	5	ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature3_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFP IGFBP2 TEK NOTCH4 LIMS2	1.14e-07	197	27	5	21a1080e1db3a64f3eccc7aed2b3189332d31038
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.14e-07	197	27	5	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_capillary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NRXN3 TEK ADAMTS6 NOTCH4 LIMS2	1.14e-07	197	27	5	81718164c9802ee20c860ffbda7e62d5e9a76f16
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFP IGFBP2 TEK NOTCH4 LIMS2	1.14e-07	197	27	5	88859b7b24b36afab4a684fd7abf0e0f8e5b525c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.17e-07	198	27	5	5e781583908c4ee107d986904a646a7c6b8e3591
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.17e-07	198	27	5	f88198e11e835ad53d339c312f8f7b7b0b5c02d3
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.20e-07	199	27	5	a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.20e-07	199	27	5	9b02acae6325b0ac9642438a4431285ff396e5fe
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.20e-07	199	27	5	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.23e-07	200	27	5	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4 LIMS2	1.23e-07	200	27	5	93e13937ec74418a697c37d56f57509fb2154780
ToppCell	Control-Endothelial-Endothelial-Activated_Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK RNF122 NOTCH4	8.33e-07	121	27	4	a5962d1c476e6966870832b72d511607e047248b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 JAG1 NOTCH4	1.96e-06	150	27	4	322aa0c3fc159a4b2897daac881dfc744b24ffc4
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NRXN3 LDLRAD3 MFRP RNF122	2.24e-06	155	27	4	1882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TEK ADAMTS6 JAG1 NOTCH4	2.66e-06	162	27	4	25bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	2.94e-06	166	27	4	8e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	2.94e-06	166	27	4	8e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	TEK ADAMTS6 NOTCH4 LIMS2	3.08e-06	168	27	4	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TEK ADAMTS6 NOTCH4 LIMS2	3.38e-06	172	27	4	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TEK JAG1 NOTCH4 LIMS2	3.46e-06	173	27	4	3a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	3.54e-06	174	27	4	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	TEK ADAMTS6 NOTCH4 LIMS2	3.54e-06	174	27	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	IPF-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	RNF122 LPAR1 CTSW JAG1	3.62e-06	175	27	4	b6d1e40d9339426d778481fd67ab7cbc0f6cb5b2
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TEK JAG1 NOTCH4 LIMS2	3.70e-06	176	27	4	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TEK JAG1 NOTCH4 LIMS2	3.70e-06	176	27	4	96779273b94345250cf53ba671203345b43d9e00
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 JAG1 NOTCH4	3.96e-06	179	27	4	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TEK RNF122 NOTCH4 LIMS2	4.05e-06	180	27	4	efc4c5a4dea456527526bbfd88cf70d803893671
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	TEK ADAMTS6 NOTCH4 LIMS2	4.14e-06	181	27	4	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TEK RNF122 JAG1 NOTCH4	4.14e-06	181	27	4	9cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TEK RNF122 ADAMTS6 NOTCH4	4.32e-06	183	27	4	858682df5592c6856487487a7baabd6e60e63a38
ToppCell	3'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TEK RNF122 ADAMTS6 NOTCH4	4.32e-06	183	27	4	f8212bf8a8b8312434ae030261c558c147f61747
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TEK JAG1 NOTCH4 LIMS2	4.41e-06	184	27	4	842473fa415575441b595073a994b6d621169776
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	IGFBP2 RNF122 CTSW JAG1	4.51e-06	185	27	4	520795866d44def5be3910ce8e728045c716a24d
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	TEK ADAMTS6 NOTCH4 LIMS2	4.51e-06	185	27	4	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	TEK ADAMTS6 NOTCH4 LIMS2	4.71e-06	187	27	4	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	Control-Endothelial_cells-Endothelial_cells_(general)\|Control / group, cell type (main and fine annotations)	NRXN3 TEK NOTCH4 LIMS2	4.71e-06	187	27	4	fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TEK JAG1 NOTCH4 LIMS2	4.81e-06	188	27	4	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 NOTCH4 LIMS2	4.81e-06	188	27	4	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IGFBP2 TEK NOTCH4 LIMS2	4.81e-06	188	27	4	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLIT2 LDLRAD3 LPAR1 SVEP1	4.81e-06	188	27	4	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	Endothelial-endothelial_cell_of_artery\|World / Lineage, Cell type, age group and donor	TEK ADAMTS6 NOTCH4 LIMS2	4.91e-06	189	27	4	fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	4.91e-06	189	27	4	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TEK JAG1 NOTCH4 LIMS2	4.91e-06	189	27	4	1e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_bronchial_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IGFBP2 TEK NOTCH4 LIMS2	4.91e-06	189	27	4	033a2be8bbb7bfb437e6f1657b6ca02070c74aa8
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like\|lymph-node_spleen / Manually curated celltypes from each tissue	LDLRAD3 LPAR1 CTSW JAG1	5.01e-06	190	27	4	0c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	TEK ADAMTS6 NOTCH4 LIMS2	5.01e-06	190	27	4	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	NRXN3 TEK ADAMTS6 NOTCH4	5.01e-06	190	27	4	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 NOTCH4 LIMS2	5.01e-06	190	27	4	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	TEK ADAMTS6 NOTCH4 LIMS2	5.01e-06	190	27	4	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 NOTCH4	5.01e-06	190	27	4	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	5.12e-06	191	27	4	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 LDLRAD3 RNF122 LPAR1	5.12e-06	191	27	4	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature3_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFP TEK NOTCH4 LIMS2	5.22e-06	192	27	4	7dbe3117a0f58ff2e838963d49f788a59a4351d7
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TEK ADAMTS6 NOTCH4 LIMS2	5.22e-06	192	27	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 LIMS2	5.22e-06	192	27	4	52acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK RNF122 NOTCH4	5.22e-06	192	27	4	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Vein\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 LIMS2	5.22e-06	192	27	4	81baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SLIT2 LDLRAD3 LPAR1 SVEP1	5.22e-06	192	27	4	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	droplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEK JAG1 NOTCH4 LIMS2	5.22e-06	192	27	4	144503af50274eaed5cf6effa892c640eab28663
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	5.22e-06	192	27	4	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFBP2 TEK ADAMTS6 LIMS2	5.22e-06	192	27	4	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Early_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IGFBP2 TEK NOTCH4 LIMS2	5.22e-06	192	27	4	4986ef70a665fdfa1df86f7f8a15117487eae159
ToppCell	droplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEK JAG1 NOTCH4 LIMS2	5.22e-06	192	27	4	c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	5.22e-06	192	27	4	56b021c297a21dff357531f21e2464f85186106d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEK ADAMTS6 NOTCH4 LIMS2	5.22e-06	192	27	4	28eb3a5728e8901bcb5ba12f6b009f41b065fa37
Drug	Dihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	MST1R SLIT2 RNF122 NSD3 LIMS2	2.81e-06	192	27	5	4152_DN
Drug	Nitrendipine [39562-70-4]; Up 200; 11uM; MCF7; HT_HG-U133A	NRXN3 PHF20 RNF122 LPAR1 TG	3.11e-06	196	27	5	6464_UP
Drug	Vitexin [3681-93-4]; Up 200; 9.2uM; PC3; HT_HG-U133A	CFP ADAM2 PHF20 JAG1 NSD3	3.43e-06	200	27	5	4588_UP
Drug	enzacamene	PRKN NRXN1 JAG1 NOTCH4	1.56e-05	129	27	4	ctd:C038939
Drug	octylmethoxycinnamate	PRKN NRXN1 JAG1 NOTCH4	2.09e-05	139	27	4	ctd:C118580
Drug	butylparaben	PRKN NRXN1 JAG1 NOTCH4	3.37e-05	157	27	4	ctd:C038091
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A	TAF15 NRXN3 RNF122 HOXB13	6.95e-05	189	27	4	3733_DN
Drug	Benzethonium chloride [121-54-0]; Down 200; 9uM; HL60; HT_HG-U133A	CFP TAF15 RNF122 LPAR1	6.95e-05	189	27	4	2508_DN
Drug	Nifuroxazide [965-52-6]; Down 200; 14.6uM; PC3; HT_HG-U133A	ADAM2 RNF122 JAG1 NSD3	7.54e-05	193	27	4	4253_DN
Drug	Metronidazole [443-48-1]; Down 200; 23.4uM; MCF7; HT_HG-U133A	PHF20 RNF122 NSD3 LIMS2	7.69e-05	194	27	4	4141_DN
Drug	Tocainide hydrochloride; Down 200; 17.4uM; PC3; HT_HG-U133A	PHF20 RNF122 SVEP1 JAG1	8.00e-05	196	27	4	4256_DN
Drug	2-propylpentanoic acid; Up 200; 1000uM; PC3; HT_HG-U133A	NRXN3 JAG1 NSD3 LIMS2	8.16e-05	197	27	4	4433_UP
Drug	Cinchonine [118-10-5]; Down 200; 13.6uM; HL60; HT_HG-U133A	CFP TAF15 PHF20 RNF122	8.16e-05	197	27	4	2133_DN
Drug	Primidone [125-33-7]; Down 200; 18.4uM; HL60; HT_HG-U133A	CFP IGFBP2 RNF122 LIMS2	8.16e-05	197	27	4	3065_DN
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; HL60; HT_HG-U133A	CFP IGFBP2 LPAR1 NSD3	8.32e-05	198	27	4	3051_DN
Drug	Procarbazine hydrochloride [366-70-1]; Up 200; 15.6uM; MCF7; HT_HG-U133A	SLIT2 ADAM2 SVEP1 NSD3	8.32e-05	198	27	4	3533_UP
Drug	Dacarbazine [4342-03-4]; Up 200; 22uM; MCF7; HT_HG-U133A	MST1R SLIT2 JAG1 LIMS2	8.49e-05	199	27	4	6816_UP
Drug	Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; HL60; HT_HG-U133A	CFP TEK LPAR1 SVEP1	8.49e-05	199	27	4	2376_UP
Drug	SC-58125; Up 200; 10uM; SKMEL5; HG-U133A	MST1R ADAMTS6 DUS4L TG	8.49e-05	199	27	4	507_UP
Drug	Sparteine (-) [90-39-1]; Down 200; 17uM; HL60; HT_HG-U133A	CFP TAF15 PHF20 RNF122	8.65e-05	200	27	4	2134_DN
Drug	2-Chloropyrazine [14508-49-7]; Down 200; 35uM; PC3; HT_HG-U133A	TAF15 RNF122 SVEP1 LIMS2	8.65e-05	200	27	4	5750_DN
Drug	Androgen Antagonists	PRKN NRXN1 NOTCH4	9.49e-05	75	27	3	ctd:D000726
Drug	glufosinate	ADAM2 MFRP NSD3	9.87e-05	76	27	3	CID000004794
Drug	lead stearate	IGFBP2 JAG1 NOTCH4	1.33e-04	84	27	3	CID000061258
Drug	isepamicin	MST1R JAG1	1.41e-04	15	27	2	CID000003755
Drug	cefpirom	CFP PHF20	1.41e-04	15	27	2	CID004487900
Disease	ductal carcinoma in situ (is_implicated_in)	HOXB13 NOTCH4	1.69e-05	7	27	2	DOID:0060074 (is_implicated_in)
Disease	corpus callosum volume measurement	MST1R JAG1 TG	1.04e-04	100	27	3	EFO_0010299
Disease	longevity	MFRP NRXN1 SVEP1 NOTCH4	1.24e-04	284	27	4	EFO_0004300
Disease	Uncinate Epilepsy	SLIT2 TEK	2.02e-04	23	27	2	C0014558
Disease	Epilepsy, Temporal Lobe	SLIT2 TEK	2.02e-04	23	27	2	C0014556
Disease	Epilepsy, Benign Psychomotor, Childhood	SLIT2 TEK	2.02e-04	23	27	2	C0393672
Disease	Epilepsy, Lateral Temporal	SLIT2 TEK	2.02e-04	23	27	2	C0393682
Disease	Carcinoma, Pancreatic Ductal	JAG1 NOTCH4	2.20e-04	24	27	2	C0887833
Disease	temperament and character inventory	NRXN1 TG	2.20e-04	24	27	2	EFO_0004825
Disease	corpus callosum mid-anterior volume measurement	JAG1 TG	2.79e-04	27	27	2	EFO_0010297
Disease	caudate volume change measurement, age at assessment	NRXN3 NRXN1	2.79e-04	27	27	2	EFO_0008007, EFO_0021491
Disease	interleukin 5 measurement	NRXN3 HOXB13	3.00e-04	28	27	2	EFO_0008185
Disease	Malignant neoplasm of breast	CFP TEK LPAR1 HOXB13 JAG1 NOTCH4	3.52e-04	1074	27	6	C0006142
Disease	endometrial cancer (is_marker_for)	HOXB13 NOTCH4	4.71e-04	35	27	2	DOID:1380 (is_marker_for)
Disease	cervical cancer (is_marker_for)	PRKN HOXB13	4.98e-04	36	27	2	DOID:4362 (is_marker_for)
Disease	hippocampal CA3 volume	SLIT2 JAG1	4.98e-04	36	27	2	EFO_0009395
Disease	Malignant neoplasm of salivary gland	IGFBP2 JAG1	7.79e-04	45	27	2	C0220636
Disease	Osteosarcoma	MST1R TAF15	8.50e-04	47	27	2	C0029463
Disease	Salivary Gland Neoplasms	IGFBP2 JAG1	8.50e-04	47	27	2	C0036095
Disease	multiple sclerosis (is_marker_for)	PRKN JAG1	9.23e-04	49	27	2	DOID:2377 (is_marker_for)
Disease	Schizophrenia	NRXN3 NRXN1 LPAR1 JAG1 NOTCH4	1.11e-03	883	27	5	C0036341
Disease	response to lithium ion	NRXN3 NOTCH4	1.20e-03	56	27	2	GO_0010226
Disease	Mammary Neoplasms, Human	LPAR1 HOXB13 JAG1 NOTCH4	1.26e-03	525	27	4	C1257931
Disease	Mammary Carcinoma, Human	LPAR1 HOXB13 JAG1 NOTCH4	1.26e-03	525	27	4	C4704874
Disease	Mammary Neoplasms	LPAR1 HOXB13 JAG1 NOTCH4	1.27e-03	527	27	4	C1458155
Disease	Breast Carcinoma	LPAR1 HOXB13 JAG1 NOTCH4	1.37e-03	538	27	4	C0678222
Disease	brain measurement, neuroimaging measurement	SLIT2 LPAR1 JAG1 TG	1.49e-03	550	27	4	EFO_0004346, EFO_0004464
Disease	Alzheimer's disease (is_marker_for)	PRKN ADAM2 IGFBP2	1.64e-03	257	27	3	DOID:10652 (is_marker_for)
Disease	Autistic Disorder	PRKN NRXN3 NRXN1	1.71e-03	261	27	3	C0004352
Disease	radiation-induced disorder	SLIT2 NRXN1	1.72e-03	67	27	2	EFO_0009565
Disease	lymphocyte count	MST1R PRKN LDLRAD3 LPAR1 JAG1 LIMS2	1.78e-03	1464	27	6	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
PCGLNQWICIDGVCM	ADAM2	476	Q99965
DWGQCSAQCGLGQQM	ADAMTS6	1026	Q9UKP5
GDWVCPNPSCGNMNF	TAF15	356	Q92804
LSCQAGGCKGVQWMC	MFRP	426	Q9BY79
MCSNGRCIPGAWQCD	LDLRAD3	36	Q86YD5
MNNNWHPGCFRCELC	LIMS2	91	Q7Z4I7
NGNINWNCPCLGGMA	CHCHD4	46	Q8N4Q1
WNCICDIENCSNMAP	LPAR1	186	Q92633
QCKMSLNGQRGECWC	IGFBP2	271	P18065
QGVCMQQWEGFTCDC	NRXN3	1061	Q9Y4C0
ACEDQQCCPEMGGWS	CFP	126	P27918
LSNPCKNNGMCRDGW	NRXN1	681	Q9ULB1
DQKNCNCCWAMAAAG	CTSW	146	P56202
DINCGCPQRWAMAEG	DUS4L	111	O95620
GGWNSQMCCQGEQNP	HOXB13	176	Q92826
CDCLPGWMGQNCDIN	JAG1	436	P78504
GWMGQNCDININDCL	JAG1	441	P78504
ECQCWQHGVCMGLLE	PHF20	671	Q9BVI0
CWNCGCEWNRVCMGD	PRKN	446	O60260
NACSCPEGWMGRLCE	SVEP1	3486	Q4LDE5
PQCSCMPGWTGEQCQ	NOTCH4	141	Q99466
PNLCSGNGQCMEWGC	VWDE	891	Q8N2E2
MHPFQWCNGCFCGLG	RNF122	1	Q9H9V4
CECQEGWMGPLCDQR	SLIT2	1356	O94813
WGPECNHLCTACMNN	TEK	216	Q02763
ECLSIEMPEGCWNCN	NSD3	936	Q9BZ95
EMPEGCWNCNDCKAG	NSD3	941	Q9BZ95
CDQAQGSCWCVMDSG	TG	1181	P01266
MCGQQKECPGSWQQD	MST1R	551	Q04912