Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T33 OR5D14 OR9I1 FFAR3 GPR42 OR6Q1 FFAR2 OR5AK3P PTH2R OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 CCR1 CCR4 CCR8	5.22e-05	884	154	19	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T33 OR5D14 OR9I1 OR6Q1 OR5AK3P OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	1.33e-04	431	154	12	GO:0004984
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42 FFAR2	4.00e-07	3	153	3	GO:0002879
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42 FFAR2	1.59e-06	4	153	3	GO:0002877
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42 FFAR2	3.96e-06	5	153	3	GO:0002525
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T33 OR5D14 OR9I1 OR6Q1 OR5AK3P OR2AJ1 TTC8 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 UBR3	9.94e-06	465	153	14	GO:0007608
GeneOntologyBiologicalProcess	maintenance of lens transparency	GCNT2 ALDH1A1 MUC5AC	2.18e-05	8	153	3	GO:0036438
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T33 OR5D14 OR9I1 OR6Q1 OR5AK3P OR2AJ1 TTC8 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 UBR3	5.91e-05	547	153	14	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T33 OR5D14 OR9I1 OR6Q1 OR5AK3P OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	9.45e-05	432	153	12	GO:0050911
GeneOntologyBiologicalProcess	negative regulation of protein secretion	RHBDF1 RHBDF2 STXBP5L FFAR3 GPR42 FFAR2	1.19e-04	103	153	6	GO:0050709
GeneOntologyBiologicalProcess	fructosamine metabolic process	FN3K ALDH1A1	1.63e-04	3	153	2	GO:0030389
HumanPheno	Microlissencephaly	RELN KATNB1 CIT	1.85e-05	6	51	3	HP:0045028
Domain	GPR40-rel_orph	FFAR3 GPR42 FFAR2	2.14e-06	4	153	3	IPR013312
Domain	-	SEMA6B POC1A STXBP5L DCAF8L2 KATNB1 SEMA3G NBAS WDR45 TLE3 TLE4 SEMA4A PAK1IP1 MAPKBP1	3.71e-06	333	153	13	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA6B POC1A STXBP5L DCAF8L2 KATNB1 SEMA3G NBAS WDR45 TLE3 TLE4 SEMA4A PAK1IP1 MAPKBP1	3.96e-06	335	153	13	IPR015943
Domain	7tm_1	OR2T33 OR5D14 OR9I1 FFAR3 GPR42 OR6Q1 FFAR2 OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 CCR1 CCR4 CCR8	4.12e-05	677	153	17	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T33 OR5D14 OR9I1 FFAR3 GPR42 OR6Q1 FFAR2 OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 CCR1 CCR4 CCR8	4.77e-05	685	153	17	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T33 OR5D14 OR9I1 FFAR3 GPR42 OR6Q1 FFAR2 OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 CCR1 CCR4 CCR8	5.31e-05	691	153	17	PS50262
Domain	GPCR_Rhodpsn	OR2T33 OR5D14 OR9I1 FFAR3 GPR42 OR6Q1 FFAR2 OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 CCR1 CCR4 CCR8	5.40e-05	692	153	17	IPR000276
Domain	Rhomboid_SP	RHBDF1 RHBDF2	6.67e-05	2	153	2	PF12595
Domain	Rhomboid_SP	RHBDF1 RHBDF2	6.67e-05	2	153	2	IPR022241
Domain	TRPV5/TRPV6	TRPV6 TRPV5	6.67e-05	2	153	2	IPR008344
Domain	WD_REPEATS_2	POC1A STXBP5L DCAF8L2 KATNB1 NBAS WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	1.04e-04	279	153	10	PS50082
Domain	WD_REPEATS_REGION	POC1A STXBP5L DCAF8L2 KATNB1 NBAS WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	1.04e-04	279	153	10	PS50294
Domain	SBF2	SBF1 SBF2	1.99e-04	3	153	2	PF12335
Domain	SBF1/SBF2	SBF1 SBF2	1.99e-04	3	153	2	IPR022096
Domain	Chemokine_rcpt	CCR1 CCR4 CCR8	2.79e-04	16	153	3	IPR000355
Domain	WD40	POC1A STXBP5L DCAF8L2 KATNB1 WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	2.90e-04	259	153	9	PF00400
Domain	WD40	POC1A STXBP5L DCAF8L2 KATNB1 WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	3.72e-04	268	153	9	SM00320
Domain	Olfact_rcpt	OR2T33 OR5D14 OR9I1 OR6Q1 OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	4.03e-04	393	153	11	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR2T33 OR5D14 OR9I1 FFAR3 OR6Q1 FFAR2 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1 CCR1 CCR4 CCR8	4.09e-04	670	153	15	IPR017452
Domain	WD40_repeat	POC1A STXBP5L DCAF8L2 KATNB1 WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	4.15e-04	272	153	9	IPR001680
Domain	VWC_out	FRAS1 TECTA MUC5AC	4.74e-04	19	153	3	SM00215
Domain	WD_REPEATS_1	POC1A STXBP5L KATNB1 NBAS WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	4.86e-04	278	153	9	PS00678
Domain	Semaphorin	SEMA6B SEMA3G SEMA4A	5.55e-04	20	153	3	IPR027231
Domain	Groucho_enhance	TLE3 TLE4	6.56e-04	5	153	2	IPR009146
Domain	TLE_N	TLE3 TLE4	6.56e-04	5	153	2	PF03920
Domain	Groucho/TLE_N	TLE3 TLE4	6.56e-04	5	153	2	IPR005617
Domain	SET_dom	SETD4 PRDM4 PRDM10 PRDM14	7.44e-04	50	153	4	IPR001214
Domain	SET	SETD4 PRDM4 PRDM10 PRDM14	7.44e-04	50	153	4	PS50280
Domain	WD40_repeat_dom	POC1A STXBP5L DCAF8L2 KATNB1 WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	7.79e-04	297	153	9	IPR017986
Domain	Metallophos	TMEM62 PPP4C PPP6C	1.52e-03	28	153	3	PF00149
Domain	Calcineurin-like_PHP_ApaH	TMEM62 PPP4C PPP6C	1.52e-03	28	153	3	IPR004843
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	31719611
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	25581519
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	31272808
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	38524121
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	16123168
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	23066016
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	22190648
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	29768180
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42 FFAR2	8.85e-08	3	156	3	38329121
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42 FFAR2	3.53e-07	4	156	3	9344866
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42 FFAR2	3.53e-07	4	156	3	21518883
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42 FFAR2	3.53e-07	4	156	3	15684720
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42 FFAR2	3.53e-07	4	156	3	29644622
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T33 OR5D14 OR9I1 OR5AK3P OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	4.37e-07	340	156	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T33 OR5D14 OR9I1 OR5AK3P OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	4.37e-07	340	156	11	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T33 OR5D14 OR9I1 OR5AK3P OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	4.77e-07	343	156	11	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T33 OR5D14 OR9I1 OR5AK3P OR2AJ1 OR52B4 OR52R1 OR4P4 OR10G2 OR51I1 OR51M1	5.20e-07	346	156	11	14611657
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42 FFAR2	8.79e-07	5	156	3	24327954
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42 FFAR2	8.79e-07	5	156	3	19009545
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42 FFAR2	1.75e-06	6	156	3	19460454
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42 FFAR2	4.88e-06	8	156	3	34626852
Pubmed	RhoE binds to ROCK I and inhibits downstream signaling.	CIT RND3 RHPN2	7.29e-06	9	156	3	12773565
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CALCOCO2 CFH MBTD1 MYO6 IRAK1 SETD4 ADAR CIT PTH2R ZP1 CYFIP1 AGO1 ACTR6 PIK3R2 CAPRIN2 ALDH1B1 POLG2 TOP3B	1.27e-05	1242	156	18	30973865
Pubmed	Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.	TLE3 TLE4 ALDH1A1	1.42e-05	11	156	3	28800615
Pubmed	Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.	CCR4 CCR8	2.00e-05	2	156	2	19062085
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	2.00e-05	2	156	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	2.00e-05	2	156	2	30478340
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV6 TRPV5	2.00e-05	2	156	2	20178461
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV6 TRPV5	2.00e-05	2	156	2	22354706
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV6 TRPV5	2.00e-05	2	156	2	16564089
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV6 TRPV5	2.00e-05	2	156	2	19295174
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV6 TRPV5	2.00e-05	2	156	2	23968883
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV6 TRPV5	2.00e-05	2	156	2	12390878
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	2.00e-05	2	156	2	35858247
Pubmed	Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.	FFAR3 FFAR2	2.00e-05	2	156	2	18801738
Pubmed	Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking.	RHBDF1 RHBDF2	2.00e-05	2	156	2	35585977
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	2.00e-05	2	156	2	22506074
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV6 TRPV5	2.00e-05	2	156	2	30916584
Pubmed	An integrated PKD1-dependent signaling network amplifies IRE1 prosurvival signaling.	ERN1 PKD1	2.00e-05	2	156	2	31167779
Pubmed	Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.	FFAR3 FFAR2	2.00e-05	2	156	2	28322790
Pubmed	Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.	TLE3 TLE4	2.00e-05	2	156	2	25446531
Pubmed	Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.	RHBDF1 RHBDF2	2.00e-05	2	156	2	23969955
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV6 TRPV5	2.00e-05	2	156	2	16565876
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	2.00e-05	2	156	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	2.00e-05	2	156	2	36362376
Pubmed	Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.	RHBDF1 RHBDF2	2.00e-05	2	156	2	32646486
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV6 TRPV5	2.00e-05	2	156	2	16705151
Pubmed	Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line.	FFAR3 FFAR2	2.00e-05	2	156	2	16887331
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	2.00e-05	2	156	2	20399779
Pubmed	LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells.	MMP9 MUC5AC	2.00e-05	2	156	2	19501047
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV6 TRPV5	2.00e-05	2	156	2	20405023
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV6 TRPV5	2.00e-05	2	156	2	11846401
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	2.00e-05	2	156	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	2.00e-05	2	156	2	26522986
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV6 TRPV5	2.00e-05	2	156	2	24761864
Pubmed	FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells.	FFAR3 FFAR2	2.00e-05	2	156	2	33020504
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	2.00e-05	2	156	2	27664183
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV6 TRPV5	2.00e-05	2	156	2	12077127
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV6 TRPV5	2.00e-05	2	156	2	24592736
Pubmed	Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination.	SBF1 SBF2	2.00e-05	2	156	2	34718573
Pubmed	FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing.	FFAR3 FFAR2	2.00e-05	2	156	2	28883043
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	2.00e-05	2	156	2	37019194
Pubmed	Regulation of high glucose-mediated mucin expression by matrix metalloproteinase-9 in human airway epithelial cells.	MMP9 MUC5AC	2.00e-05	2	156	2	25704757
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	2.00e-05	2	156	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	2.00e-05	2	156	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	2.00e-05	2	156	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	2.00e-05	2	156	2	27550964
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV6 TRPV5	2.00e-05	2	156	2	12574114
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV6 TRPV5	2.00e-05	2	156	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV6 TRPV5	2.00e-05	2	156	2	19140341
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	2.00e-05	2	156	2	32073900
Pubmed	TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.	TLE3 TLE4	2.00e-05	2	156	2	36801171
Pubmed	Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma.	FFAR3 FFAR2	2.00e-05	2	156	2	28075383
Pubmed	Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.	MMP9 MUC5AC	2.00e-05	2	156	2	15531749
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	2.00e-05	2	156	2	19630535
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV6 TRPV5	2.00e-05	2	156	2	25164318
Pubmed	Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways.	RHBDF1 RHBDF2	2.00e-05	2	156	2	31661139
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	2.00e-05	2	156	2	14722361
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV6 TRPV5	2.00e-05	2	156	2	15123711
Pubmed	Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.	FFAR3 FFAR2	2.00e-05	2	156	2	21220428
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV6 TRPV5	2.00e-05	2	156	2	11719848
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV6 TRPV5	2.00e-05	2	156	2	17233615
Pubmed	Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis.	PKD1 PAPPA	2.00e-05	2	156	2	31990681
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	2.00e-05	2	156	2	26260360
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42 FFAR2	3.87e-05	15	156	3	32641826
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6B FRAS1 MSRB1 RHBDF1 RHBDF2 TMEM8B RNPEPL1 IRAK1 ZZEF1 CIT SBF1 MTMR14 SBF2 PKD1 MAPKBP1 TOP3B	4.01e-05	1105	156	16	35748872
Pubmed	[TSTA3 gene promotes esophageal cancer invasion through MAPK-ERK pathway and downstream MMP2/9].	GFUS MMP9	5.98e-05	3	156	2	34979755
Pubmed	Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis.	CCR4 CCR8	5.98e-05	3	156	2	16239514
Pubmed	Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.	RHBDF1 RHBDF2	5.98e-05	3	156	2	28104813
Pubmed	Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function.	CALCOCO2 MYO6	5.98e-05	3	156	2	31744880
Pubmed	Analysis of the expression levels of chemerin, ox-LDL, MMP-9, and PAPP-A in ICVD patients and their relationship with the severity of neurological impairment.	PAPPA MMP9	5.98e-05	3	156	2	35620813
Pubmed	T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.	CALCOCO2 MYO6	5.98e-05	3	156	2	17635994
Pubmed	Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens.	ALDH1A1 ALDH1B1	5.98e-05	3	156	2	12693930
Pubmed	Expression of protease-activated receptor-2 (PAR-2) in patients with nasopharyngeal carcinoma: correlation with clinicopathological features and prognosis.	PDLIM7 MMP9	5.98e-05	3	156	2	19269113
Pubmed	Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.	MMP9 MUC5AC	5.98e-05	3	156	2	18006877
Pubmed	Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.	TRPV6 TRPV5	5.98e-05	3	156	2	17200157
Cytoband	11p15.4	TRIM68 OR52B4 OR52R1 OR51I1 OR51M1 SBF2	6.70e-05	200	156	6	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR5D14 OR4P4 TRIM48	3.47e-04	40	156	3	chr11q11
Cytoband	6p24.2	GCNT2 PAK1IP1	5.07e-04	10	156	2	6p24.2
Cytoband	2p24	DTNB NBAS	7.40e-04	12	156	2	2p24
Cytoband	19q13.1	FFAR3 GPR42 FFAR2	8.87e-04	55	156	3	19q13.1
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR1 CCR4 CCR8	3.39e-05	10	121	3	1091
GeneFamily	WD repeat domain containing	POC1A STXBP5L DCAF8L2 KATNB1 WDR45 TLE3 TLE4 PAK1IP1 MAPKBP1	6.76e-05	262	121	9	362
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	SBF1 MTMR14 SBF2	1.25e-04	15	121	3	903
GeneFamily	Cadherin related	CDHR2 CLSTN2 FAT2	1.86e-04	17	121	3	24
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM4 PRDM10 PRDM14	1.86e-04	17	121	3	1197
GeneFamily	Free fatty acid receptors	FFAR3 FFAR2	2.64e-04	4	121	2	203
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6B SEMA3G SEMA4A	3.07e-04	20	121	3	736
GeneFamily	Phospholipid phosphatase related	PLPPR4 PLPPR2	4.38e-04	5	121	2	1127
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP4C PPP6C	3.30e-03	13	121	2	693
GeneFamily	Rhomboid family	RHBDF1 RHBDF2	3.84e-03	14	121	2	926
ToppCell	droplet-Fat-Mat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC GYG1 CCR1 SEMA4A MMP9	1.78e-06	164	155	7	a27b9b3380f29bb17c9f787423f2591f2b9cf33e
ToppCell	droplet-Marrow-nan-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 PDLIM7 GCNT2 GYG1 CCR1 MMP9 MOV10	2.95e-06	177	155	7	5d70fe2b0592362d664b3b4c84eb450ec2335957
ToppCell	droplet-Marrow-nan-18m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 PDLIM7 GCNT2 GYG1 CCR1 MMP9 MOV10	2.95e-06	177	155	7	48bcf603ec9593eedd81f3831cf9fde89fad368f
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFH FRAS1 ABCA8 RND3 SBSPON UPK1B PAPPA	6.59e-06	200	155	7	c800f20adedf4ca736c740510889e92d8bf0ba44
ToppCell	Parenchyma_COVID-19-Stromal-TX-Mesothelial-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	CFH FRAS1 ABCA8 RND3 SBSPON UPK1B PAPPA	6.59e-06	200	155	7	bf50e30d5cafb71c567e89580f62084d2f894170
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH FRAS1 ABCA8 RND3 SBSPON UPK1B PAPPA	6.59e-06	200	155	7	5e5ad07679d5dd2ca80249bce9aaf4a95d42187b
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MSRB1 FFAR2 PLPPR4 CCR1 SEMA4A MMP9	9.73e-06	140	155	6	90298cac4bcec614a48e60b5c139c86daa9f0321
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MSRB1 FFAR2 PLPPR4 CCR1 SEMA4A MMP9	9.73e-06	140	155	6	671ab1f5cbd8568bf93ebdf961c2a1ede06d2bcb
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFH FRAS1 CDHR2 STXBP5L FAT2 TRPV6	1.67e-05	154	155	6	38d346402417960044ae999e61f0092b46f2b591
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CFH IL16 RND3 GYG1 MMP9 LRRC17	2.01e-05	159	155	6	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	facs-Lung-EPCAM-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.01e-05	159	155	6	baf843dc44b072504eb1d28de55b1ee67aeec32b
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.01e-05	159	155	6	9eb78202b9a4e8217f00e64d5142ed28c00abd04
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 USP32 CCR1 MMP9 MOV10	2.15e-05	161	155	6	e227f7b711475624cf80e77f235b1783d88d57b4
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 USP32 CCR1 MMP9 MOV10	2.15e-05	161	155	6	8280a029026c272cae9649b27575831b0dd4e242
ToppCell	droplet-Lung-nan-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA6B MSRB1 GCNT2 CCR1 MMP9 MOV10	2.39e-05	164	155	6	0e424a69999eee13d27c4ff4f4ba3df64d3c2bda
ToppCell	droplet-Fat-Gat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL16 MSRB1 GCNT2 CCR1 SEMA4A MMP9	2.39e-05	164	155	6	c7ad946829c655038b33748dddd7d68c15489034
ToppCell	droplet-Fat-Gat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL16 MSRB1 GCNT2 CCR1 SEMA4A MMP9	2.39e-05	164	155	6	3aae702a23fbf1d36a6f18596c23e985581de815
ToppCell	droplet-Lung-nan-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA6B MSRB1 GCNT2 CCR1 MMP9 MOV10	2.39e-05	164	155	6	fe9ecdd7a6cbaf910f42654eba75f79bea740a00
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DTNB TMEM62 CYFIP1 CCR1 MMP9	2.47e-05	165	155	6	47e716ce8dc283d406352c1909e09362fcb9e3a3
ToppCell	droplet-Heart-4Chambers-18m-Myeloid-cardiac_mast_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.47e-05	165	155	6	a761e0a36d5da8fec916d684f81e60f5590fd9ee
ToppCell	droplet-Fat-Gat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.47e-05	165	155	6	c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCell	droplet-Heart-4Chambers-18m-Myeloid-mast_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.47e-05	165	155	6	680bdd150bc0a4e50244e57b1226a9b06a6bdbc9
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DTNB TMEM62 CYFIP1 CCR1 MMP9	2.47e-05	165	155	6	fe2135fdacf3807eb4b5ea5e790febfb8cd54335
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETD4 ZP1 PHAF1 GJE1 UPK1B HYDIN	2.47e-05	165	155	6	936581de8fcd097401707438b9bbe89dd4e3e247
ToppCell	droplet-Fat-Gat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.47e-05	165	155	6	af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCell	droplet-Heart-4Chambers-18m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.47e-05	165	155	6	af423307af484661284793a08091777d998e6fba
ToppCell	facs-MAT-Fat-18m-Myeloid\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.56e-05	166	155	6	9116be2805c34881debb999d8417e43832fcf2f2
ToppCell	facs-MAT-Fat-18m-Myeloid-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.56e-05	166	155	6	5c2667da79935f3d4b1edbfe7a10e7dbc2fa3ad0
ToppCell	Dividing_Macrophages-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	POC1A FFAR2 ZP1 EEPD1 LYPD5 MUC5AC	2.56e-05	166	155	6	ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCell	Adult-Mesenchymal-chondrocyte-D175\|Adult / Lineage, Cell type, age group and donor	PDLIM7 CLSTN2 KCTD6 PAPPA NEURL1B MMP9	2.73e-05	168	155	6	14071b961c9bdb54a8259b12a88237b802cbde36
ToppCell	facs-BAT-Fat-24m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 PTPRC CCR1 SEMA4A MMP9	2.92e-05	170	155	6	53916d85f0d6c7e5ef3d900d6ead946f75e32567
ToppCell	facs-BAT-Fat-3m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 GCNT2 USP32 CCR1 SEMA4A MMP9	2.92e-05	170	155	6	8fd0a55266066a51266ab616c38c883e2680bcf4
ToppCell	NS-critical-d_0-4-Myeloid-Monocyte-derived_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DGKE TBC1D22B FN3K ZSCAN32 ACTR6 CAPRIN2	2.92e-05	170	155	6	adf73bdc049d508f8873c22539db2ca92052a97b
ToppCell	PND07-28-samps-Myeloid-Macrophage-CD163+_Macrophage\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CFH CYP27A1 CCR1 SEMA4A MMP9 BANK1	3.12e-05	172	155	6	9a659442dc41bd2a4361a7e38a7ee37a39781667
ToppCell	droplet-Marrow-nan-18m-Hematologic-proerythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRB1 PDLIM7 GCNT2 CCR1 MMP9 MOV10	3.22e-05	173	155	6	03cee3d24bc433e91a867ce951589de64a0538af
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN CLSTN2 SEMA3G ABCA8 PTH2R ALDH1A1	3.22e-05	173	155	6	789ab8b2709f4b8728e3733bc72744e9d92ea5ea
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN RHBDF1 SEMA3G ABCA8 SBSPON ALDH1A1	3.33e-05	174	155	6	c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN RHBDF1 SEMA3G ABCA8 SBSPON ALDH1A1	3.33e-05	174	155	6	1463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN RHBDF1 SEMA3G ABCA8 SBSPON ALDH1A1	3.33e-05	174	155	6	d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CFH RHBDF1 TRIM68 PRDM10 UPK1B PKD1	3.33e-05	174	155	6	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|normal_Lung / Location, Cell class and cell subclass	CFH FRAS1 SBSPON UPK1B PAPPA MUC5AC	3.55e-05	176	155	6	f31d7234053085a82cf9d55aeedd1e04d34789c3
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	CFH FRAS1 ABCA8 RND3 PAPPA LRRC17	4.02e-05	180	155	6	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	CFH FRAS1 ABCA8 RND3 PAPPA LRRC17	4.02e-05	180	155	6	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MSRB1 PDLIM7 FFAR2 CYP27A1 PTPRC MMP9	4.69e-05	185	155	6	97f8a644f51c02a5f8a74d8c923ad637a15ed06d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN NOX3 GCNT2 CIT PTH2R RND3	5.76e-05	192	155	6	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH IL16 CYP27A1 RND3 UPK1B ALDH1A1	5.93e-05	193	155	6	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	control-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MSRB1 FFAR2 SLFN5 ADAR CCR1 MOV10	6.10e-05	194	155	6	267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell	myeloid-Monocyte-CD14+_Monocyte\|myeloid / Lineage, cell class and subclass	SEMA6B MSRB1 PDLIM7 CYP27A1 B4GALT5 ALDH1A1	6.27e-05	195	155	6	15ba9c5f6ecb6ae2c603e6b036eb92b00b46f13f
ToppCell	(3)_MNP-(3)_Monocyte\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	SEMA6B ERN1 FFAR3 B4GALT5 PNPLA8 MMP9	6.45e-05	196	155	6	83af2eb1c28dfe7678d972be1d6d358c4a94731d
ToppCell	368C\|World / Donor, Lineage, Cell class and subclass (all cells)	CFH SEMA6B ABCA8 RND3 PAPPA MMP9	6.64e-05	197	155	6	f41211923938e5d7bfe6bf24f604ab386f17ef10
ToppCell	severe\|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MSRB1 FFAR2 B4GALT5 GYG1 CCR1 MMP9	7.02e-05	199	155	6	c24aacef7405700bc5d0b736a38feea12b7f17c8
ToppCell	mLN-ILC-ILC\|mLN / Region, Cell class and subclass	CFH DIPK1C ERN1 ABCB5 MMP9 CPNE7	7.02e-05	199	155	6	ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCell	mLN-ILC\|mLN / Region, Cell class and subclass	CFH DIPK1C ERN1 ABCB5 MMP9 CPNE7	7.02e-05	199	155	6	d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCell	mLN-(3)_ILC\|mLN / shred on region, Cell_type, and subtype	CFH DIPK1C ERN1 ABCB5 MMP9 CPNE7	7.02e-05	199	155	6	00e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCell	mLN-(3)_ILC-(30)_ILC\|mLN / shred on region, Cell_type, and subtype	CFH DIPK1C ERN1 ABCB5 MMP9 CPNE7	7.02e-05	199	155	6	33ac6d77099076df01299be429f4ba96f2f34cc1
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CFH DIPK1C FRAS1 RND3 PAPPA MMP9	7.22e-05	200	155	6	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RBM11 SEMA3G ABCA8 SBF1 SBSPON MAPKBP1	7.22e-05	200	155	6	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CFH ABCA8 RND3 PLPPR4 PAPPA ALDH1A1	7.22e-05	200	155	6	efdf7066b7dd43e35dbc0d2719b75f250cf54af2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial-Astrocyte\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DIPK1C RNPEPL1 RHPN2 GYG1 EEPD1 LRRC17	7.22e-05	200	155	6	7c66953ff6d8f16f4decd23c85232990d2d8c6c4
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH IL16 ABCA8 RND3 PLPPR4 PAPPA	7.22e-05	200	155	6	fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH IL16 ABCA8 RND3 PLPPR4 PAPPA	7.22e-05	200	155	6	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DGKE SLFN5 SEMA3G CCR4 CCR8	9.21e-05	130	155	5	d47d4ff1263815896470d854d25306eb36919e70
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DGKE SLFN5 SEMA3G CCR4 CCR8	9.21e-05	130	155	5	ad57b210c96caedadc1027b4d7a56b1bc389b137
ToppCell	COVID-19-kidney-Epithelial_Doublet\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANKRD31 ABCB5 NOX3 PTH2R BSPH1	9.21e-05	130	155	5	1ff28e9d3dc9a791e07d815f8fbb48f75d3f275b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NOX3 PTH2R TLE4 ALDH1B1 NEURL1B	1.35e-04	141	155	5	5ef3166c5271aa90fd0633016edfe2c74b835319
Disease	semaphorin-6B measurement	CFH SEMA6B KCTD6	1.23e-06	5	148	3	EFO_0021885
Disease	cytochrome C measurement	CFH SEMA6B	7.47e-05	3	148	2	EFO_0020302
Disease	interleukin-16 measurement	CFH IL16	7.47e-05	3	148	2	EFO_0801717
Disease	pulmonary fibrosis (biomarker_via_orthology)	CCR4 CCR8 MMP9 MUC5AC	1.17e-04	50	148	4	DOID:3770 (biomarker_via_orthology)
Disease	glaucoma (is_marker_for)	CFH MMP9 MUC5AC	1.32e-04	20	148	3	DOID:1686 (is_marker_for)
Disease	temporal lobe epilepsy (is_marker_for)	RELN CYFIP1 MMP9	1.32e-04	20	148	3	DOID:3328 (is_marker_for)
Disease	asthma (biomarker_via_orthology)	CCR4 CCR8 MMP9 MUC5AC	2.23e-04	59	148	4	DOID:2841 (biomarker_via_orthology)
Disease	protein delta homolog 1 measurement	CFH ABCA8	2.47e-04	5	148	2	EFO_0801938
Disease	Membranoproliferative Glomerulonephritis, Type I	CFH DGKE	3.70e-04	6	148	2	C0268742
Disease	Membranoproliferative Glomerulonephritis, Type III	CFH DGKE	3.70e-04	6	148	2	C1720821
Disease	pappalysin‐1 measurement	PAPPA BANK1 TRIM48	4.11e-04	29	148	3	EFO_0010618
Disease	microcephaly (implicated_via_orthology)	KATNB1 CIT MAPKBP1	5.51e-04	32	148	3	DOID:10907 (implicated_via_orthology)
Disease	aspartate aminotransferase measurement	CFH ANKRD31 SRMS SLC25A3 KCTD6 OR4P4 PTPRC TIAL1 TLE4 CCR8 FAM118A BANK1 MOV10	6.55e-04	904	148	13	EFO_0004736
Disease	cognitive disorder (biomarker_via_orthology)	IRAK1 MMP9	6.86e-04	8	148	2	DOID:1561 (biomarker_via_orthology)
Disease	C3 glomerulopathy	CFH DGKE	8.79e-04	9	148	2	C4087273
Disease	glycogen storage disease (is_implicated_in)	PHKA2 GYG1	8.79e-04	9	148	2	DOID:2747 (is_implicated_in)
Disease	Atypical Hemolytic Uremic Syndrome	CFH DGKE	1.10e-03	10	148	2	C2931788
Disease	diffuse scleroderma (is_implicated_in)	IRAK1 BANK1	1.33e-03	11	148	2	DOID:1580 (is_implicated_in)
Disease	intracranial aneurysm (is_implicated_in)	PKD1 MMP9	1.60e-03	12	148	2	DOID:10941 (is_implicated_in)
Disease	pancreatic cancer (is_marker_for)	CCR4 ALDH1A1 MMP9 MUC5AC	1.70e-03	101	148	4	DOID:1793 (is_marker_for)
Disease	Charcot-Marie-Tooth disease type 4	SBF1 SBF2	1.88e-03	13	148	2	cv:C4082197
Disease	membranous glomerulonephritis (biomarker_via_orthology)	CFH MMP9	2.19e-03	14	148	2	DOID:10976 (biomarker_via_orthology)
Disease	tumor necrosis factor measurement	CFH C6orf89	2.51e-03	15	148	2	EFO_0010834
Disease	hepcidin:transferrin saturation ratio	ZNF551 KCTD6	2.51e-03	15	148	2	EFO_0007902
Disease	thrombosis (is_implicated_in)	F11 MMP9	2.51e-03	15	148	2	DOID:0060903 (is_implicated_in)
Disease	autism spectrum disorder (is_implicated_in)	CYFIP1 MMP9	2.86e-03	16	148	2	DOID:0060041 (is_implicated_in)
Disease	Glycogen storage disease	PHKA2 GYG1	3.23e-03	17	148	2	cv:C0017919
Disease	squamous cell carcinoma (is_marker_for)	CFH MMP9	4.04e-03	19	148	2	DOID:1749 (is_marker_for)
Disease	Disorder of eye	FRAS1 CYP27A1 TTC8 PITPNM3 SEMA4A	4.40e-03	212	148	5	C0015397
Disease	systemising measurement	NBAS ASB3	4.93e-03	21	148	2	EFO_0010221
Disease	gastric ulcer (biomarker_via_orthology)	MMP9 MUC5AC	4.93e-03	21	148	2	DOID:10808 (biomarker_via_orthology)
Disease	cholesteryl ester measurement, high density lipoprotein cholesterol measurement	ABCA8 EEPD1 SBF2 MAPKBP1 MMP9 TRIM48	5.02e-03	312	148	6	EFO_0004612, EFO_0010351

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPFGNYSFICVDATV	TMEM62	176	Q0P6H9
FPAGSVHVNVYCDGI	BANK1	256	Q8NDB2
GYSHENVSVIPNCQF	ACTR6	16	Q9GZN1
FCVHVSNLVFAYFRG	CATSPERD	151	Q86XM0
SYCIGAAVPHFETFA	ABCB5	336	Q2M3G0
NTYNIVTCHTPFGGF	ALDH1B1	471	P30837
PFEFDFYLCSHAGIQ	AGO1	741	Q9UL18
FFTYTRHEPIGVCGQ	ALDH1A1	151	P00352
ECSSFPVYIAEGNHT	DOP1A	756	Q5JWR5
PGFLFSTCYTERNHT	CCR4	171	P51679
FTIVGPNSVQCYHFG	CFH	601	P08603
TFIIQAYDCGAGPHE	CLSTN2	121	Q9H4D0
FLPEDFTYFANHTCP	B4GALT5	101	O43286
CGLPAEYATHFTEAF	CIT	1411	O14578
GVASEHCPVLAEFYT	EEPD1	526	Q7L9B9
SFGFVCFKHPESVSY	RBM11	51	P57052
NSEGKYHCPVLFTVF	PPIL2	96	Q13356
SVYVVHDSLFGRPNC	RASA1	526	P20936
SGPNVINHFFCEYTA	OR5D14	171	Q8NGL3
VANYEQCIFGPSFDH	ANKRD31	986	Q8N7Z5
VEGHGCTFIQIFRYT	OVOS1	1086	Q6IE37
VISYGHCAAQFFLFT	OR9I1	91	Q8NGQ6
FVYCIPVGTHEFTVE	CYFIP1	1136	Q7L576
ECSVPFVPVEFHYEN	NXF3	136	Q9H4D5
HFPFIFEGRSYSACT	MMP9	231	P14780
TYVDFHPSGTCIAAA	POC1A	191	Q8NBT0
YIAGVFCAIVSHPAD	SLC25A3	271	Q00325
FLVCFGPYNVSHLVG	FFAR2	231	O15552
YNCVPGFSVHTSNET	FRAS1	1081	Q86XX4
FCYHATSPSIFPVGF	MBTD1	431	Q05BQ5
APGVSQFAYTCVQDH	SBF2	646	Q86WG5
FSVIPNTNGDICGHY	MTMR14	71	Q8NCE2
PSTEAGQVFCVFYAL	KCNK16	116	Q96T55
AEACHQIFEGKVFYP	GCNT2	46	Q8N0V5
EVDSTFCHNYVFPIQ	LRRC17	236	Q8N6Y2
ANICSLDFHPYGEFV	KATNB1	106	Q9BVA0
FPTNITCVVYSHDGT	DCAF8L2	421	P0C7V8
NEHSYGSPFTFCVVD	DSG4	516	Q86SJ6
FQFCVYVHDQGSPVL	FAT2	1836	Q9NYQ8
PTVISTFCFNYNHVA	OR51I1	81	Q9H343
KAFPYCGSVVLSHSF	OR51M1	176	Q9H341
NTFGSHVCIIILFYG	OR52B4	241	Q8NGK2
TIFVPFCGPNEIDHY	OR4P4	161	Q8NGL7
CSVPYFQCISGIFVH	IL16	371	Q14005
YGLAQIGVCFHPVFD	POLG2	206	Q9UHN1
YGCTFTAVIPTNVFG	GFUS	161	Q13630
FAFHTEFIHVPVGCT	IL17C	176	Q9P0M4
VFRFPGLCNYVFSEH	MUC5AC	96	P98088
FQEVGINYHSPFGCK	EDC3	486	Q96F86
TFYGPNVIDHFSCDA	OR6Q1	171	Q8NGQ2
HVAIHINDGYFTCPT	PRDM10	606	Q9NQV6
LQAVVTLSFPYCGAH	OR2T33	156	Q8NG76
HQVYAASFSCPEGTT	PAPPA	1291	Q13219
FRHPNIVDFAGYCAQ	IRAK1	266	P51617
FIAAEGIHTGQFVYC	RPL8	76	P62917
VCFGPYNVSHVVGYI	GPR42	236	O15529
GCHPFYESVISNPFV	NBAS	1471	A2RRP1
ALGHAYHPEEFVCSQ	PDLIM7	296	Q9NR12
SIGCSPFQFHEATIY	RELN	3166	P78509
PGVTQFAYSCVQEHV	SBF1	661	O95248
FFPQHLAFVDICYTS	OR5AK3P	61	Q8NH89
TFPVHTQGFFCYDST	PLPPR2	41	Q96GM1
AFPFCATYAVAVVGN	OR52R1	31	Q8NGF1
HYGFSEPLTFCSVVD	PIK3R2	386	O00459
CFDHFPGYVQDLATQ	FAM118A	291	Q9NWS6
VSPVYSAVFGGHEDC	ASB3	281	Q9Y575
CTFTPEEAQVNFTGY	CDHR2	361	Q9BYE9
VNTEVDFGHCFLKYP	HYDIN	701	Q4G0P3
CFNSGVFVYQPSVET	GYG1	131	P46976
VGRFSEPHACFYAAQ	PRKACG	136	P22612
FQYCVAVGAQTFPSV	ADAR	646	P55265
TDGECVFPFHYKNGT	BSPH1	41	Q075Z2
GCVFYYVISEGSHPF	ERN1	761	O75460
YTHCCVNPVIYAFVG	CCR1	291	P32246
THCCVNPVIYAFVGE	CCR8	291	P51685
FEVYDTHGPSGFSCQ	CPNE7	91	Q9UBL6
NTQFVFCHYVVSRDP	CYP27A1	421	Q02318
VCFGPYNVSHVVGYI	FFAR3	236	O14843
FAVYGNEALHFICDP	GJE1	41	A6NN92
SFGYTEHSVRTCFPQ	DTNB	186	O60941
CHFFTYATRQFPSLE	F11	146	P03951
FYIPGGDVTCHYTFT	CALCOCO2	31	Q13137
GDVTCHYTFTQHFIP	CALCOCO2	36	Q13137
RFNCPVNGTYVFIFH	CAPRIN2	1036	Q6IMN6
TVGNFSVPVYIRTCH	LYPD5	171	Q6UWN5
QEHKYGVACVAFSPS	MAPKBP1	131	O60336
SFTFGPCDYHQEVSL	KCTD6	176	Q8NC69
QNHVSYGCQSPSFIF	KRTAP25-1	16	Q3LHN0
QFTAEFSSRYGDCHP	FAF1	336	Q9UNN5
LLEVVGVYGSFHCAQ	DGKE	476	P52429
QHFLCQYPEATEGFS	C6orf89	196	Q6UWU4
GIGFNSVYHITDVPC	SACS	191	Q9NZJ4
FSVICQGFYEDIAHG	SACS	1956	Q9NZJ4
FNSVYHITDCPSFIS	SACS	2626	Q9NZJ4
PVLGSCGHFYAVEFL	DIPK1C	211	Q0P6D2
CGHFYAVEFLAAGSP	DIPK1C	216	Q0P6D2
GFQCSPYPEVDHFVL	PRIMPOL	371	Q96LW4
DQATGICHFFYDSAP	PHKA2	1191	P46019
LVAYPHDGKIFFCTS	PRDM4	501	Q9UKN5
LALPVGHYCFVFVVS	PKD1	2221	P98161
GHYCFVFVVSFGDTP	PKD1	2226	P98161
AIPFGGCVAQLYFFH	OR10G2	96	Q8NGC3
STVHTAYALQFPFCG	OR2AJ1	156	Q8NGZ0
HVFAKDCFPENYVPT	RND3	41	P61587
GFINHDCTRVASPAY	ODF3L2	56	Q3SX64
VFQNHFEPGVYVCAK	MSRB1	11	Q9NZV6
PVHQLFDYICGVSTG	PNPLA8	471	Q9NP80
YGCAKPFVFTQGHSV	RNPEPL1	186	Q9HAU8
NYFIDPVTIDCGHSF	TRIM48	36	Q8IWZ4
QSEPEGFSHFHLYVC	TBC1D22B	431	Q9NU19
GEVPHFGVFCSSFIA	PRDM14	261	Q9GZV8
HCKTSFVGYFPATVL	MOV10	201	Q9HCE1
EPQYVDKFGFHTVTC	FN3K	136	Q9H479
AVCIYGIAPVGFSQH	RHBDF1	421	Q96CC6
VTHLYTCGTFAFSPA	SEMA4A	136	Q9H3S1
FLEYGFVSVHNPHAC	SETD4	281	Q9NVD3
FALHVCDEVNVYGFG	ST3GAL2	286	Q16842
EVSESALNPQCHYGF	SHQ1	136	Q6PI26
ICVDGTFHKYVFTPD	WDR45	326	Q9Y484
TQSGAYVVTPFHCTD	SURF1	156	Q15526
SFGVLLHEVFTYGQC	SRMS	411	Q9H3Y6
YCGVHFNSQAIAPTI	PHAF1	91	Q9BSU1
IAYNHPSSSIGVFFC	NOX3	521	Q9HBY0
VQVHFLDPYCSASVA	RHPN2	536	Q8IUC4
SEYFQICKTVRHGFP	STXBP5L	56	Q9Y2K9
IHIIQIPCAVGYSFS	ABCA8	1101	O94911
AVETSTCVVFGEPHY	TECTA	316	O75443
TDVFKPVHSGFSCYD	PLPPR4	91	Q7Z2D5
CSVHEYTGTFAGQPV	TOP3B	36	O95985
FVCAHTGIIFYAPYT	MRPS18B	126	Q9Y676
NCSVPGDSHFYFNVL	SEMA6B	291	Q9H3T3
FYNVTDCGSHIFTFP	TRIM68	436	Q6AZZ1
ACIGSNHFYSDQPEI	TTC8	356	Q8TAM2
RQFCYQEVTGPHEAF	ZSCAN32	41	Q9NX65
EAFVVFYFPLTHCGT	ZP1	321	P60852
DCGHTYVPAFITTSA	SBSPON	131	Q8IVN8
HYLTCFSGTIAVPFL	SLC23A1	51	Q9UHI7
TPVTVCGDIHGQFYD	PPP6C	46	O00743
QHDFTSQIFSLGYCP	TLE4	656	Q04727
YSVNDGEPVLFHCGV	NEURL1B	156	A8MQ27
EATFVTGCRFHVLNY	ZNF551	166	Q7Z340
HVLNYFTCGEAFPAP	ZNF551	176	Q7Z340
HQDAYQAGIVFPDCF	GPLD1	56	P80108
YFGEHPLSFAACVNS	TRPV6	201	Q9H1D0
FSTFYHACDQPGIVV	TMEM8B	271	A6NDV4
GCYEQVLFGFAVHPE	PAK1IP1	6	Q9NWT1
LEQCPSIVRFGYHFT	TMOD4	306	Q9NZQ9
CRYHPTFFNDVFSTL	TTLL12	616	Q14166
VFGVHYIVFVCLPHS	PTH2R	371	P49190
FQVRPACSQVYSFFH	PITPNM3	421	Q9BZ71
HDFTSQIFSLGYCPT	TLE3	656	Q04726
AECIFFVSDQHSLYP	UPK1B	31	O75841
FYQTEHPFISASCLD	UBR3	1691	Q6ZT12
CGKAFVYPSVFQRHE	ZNF443	426	Q9Y2A4
NCHEVSVFVSPGATY	ZZEF1	1106	O43149
TVSAVFQGFAVCVYH	SEMA3G	331	Q9NS98
CTYGIAPVGFAQHVT	RHBDF2	421	Q6PJF5
DSPVTVCGDIHGQFY	PPP4C	46	P60510
FSNFFSGPIVVHCSA	PTPRC	841	P08575
ITEHTSNDPYCFVEF	TIAL1	41	Q01085
YVFFGVHDETCQVIG	SLFN5	226	Q08AF3
YSATPGADVCFARQH	USP32	481	Q8NFA0
YFGEHPLSFAACVNS	TRPV5	161	Q9NQA5
HFAGAVCYETTQFVE	MYO6	581	Q9UM54