Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainQuinoprotein_ADH-like_supfam

DMXL2 CFAP251 GEMIN5 FBXW2 EIF2AK3

2.25e-0653755IPR011047
DomainCyclin_Y

CCNYL1 CCNY

1.59e-052752IPR012399
DomainWD_REPEATS_1

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 PALB2 SEC13

1.26e-04278757PS00678
DomainWD_REPEATS_2

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 PALB2 SEC13

1.28e-04279757PS50082
DomainWD_REPEATS_REGION

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 PALB2 SEC13

1.28e-04279757PS50294
DomainWD40_repeat_dom

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 PALB2 SEC13

1.89e-04297757IPR017986
DomainSpectrin_repeat

DSP SYNE1 ACTN2

2.11e-0429753IPR002017
DomainSpectrin/alpha-actinin

DSP SYNE1 ACTN2

2.84e-0432753IPR018159
DomainSPEC

DSP SYNE1 ACTN2

2.84e-0432753SM00150
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

3.30e-047752IPR013799
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

3.30e-047752IPR012345
DomainSTAT

STAT5A STAT5B

3.30e-047752IPR001217
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

3.30e-047752IPR015988
Domain-

STAT5A STAT5B

3.30e-0477522.60.40.630
DomainSTAT_int

STAT5A STAT5B

3.30e-047752SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

3.30e-047752IPR013801
DomainSTAT_bind

STAT5A STAT5B

3.30e-047752PF02864
DomainSTAT_int

STAT5A STAT5B

3.30e-047752PF02865
Domain-

STAT5A STAT5B

3.30e-0477521.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

3.30e-047752PF01017
Domain-

STAT5A STAT5B

3.30e-0477521.20.1050.20
Domain-

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 PALB2 SEC13

3.78e-043337572.130.10.10
DomainWD40/YVTN_repeat-like_dom

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 PALB2 SEC13

3.92e-04335757IPR015943
DomainSTAT_TF_alpha

STAT5A STAT5B

4.39e-048752IPR013800
DomainWD40

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 SEC13

6.07e-04259756PF00400
DomainWD40

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 SEC13

7.26e-04268756SM00320
DomainWD40_repeat

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 SEC13

7.84e-04272756IPR001680
Domain-

ATRN KLHDC2 ATRNL1

9.45e-04487532.120.10.80
DomainKelch_2

KLHDC2 ATRNL1

1.21e-0313752IPR011498
DomainKelch_2

KLHDC2 ATRNL1

1.21e-0313752PF07646
DomainKelch-typ_b-propeller

ATRN KLHDC2 ATRNL1

1.40e-0355753IPR015915
DomainKelch_1

ATRN KLHDC2 ATRNL1

2.81e-0370753PF01344
DomainKelch_1

ATRN KLHDC2 ATRNL1

2.81e-0370753IPR006652
DomainActinin_actin-bd_CS

SYNE1 ACTN2

3.81e-0323752IPR001589
DomainSpectrin

SYNE1 ACTN2

3.81e-0323752PF00435
DomainACTININ_2

SYNE1 ACTN2

3.81e-0323752PS00020
DomainACTININ_1

SYNE1 ACTN2

3.81e-0323752PS00019
Domain-

CAPN13 CFAP251 ACTN2 STAT5A STAT5B

4.00e-032617551.10.238.10
DomainG-protein_beta_WD-40_rep

APAF1 GEMIN5 FBXW2

4.85e-0385753IPR020472
DomainCYCLINS

CCNYL1 CCNY

5.62e-0328752PS00292
DomainEF-hand-dom_pair

CAPN13 CFAP251 ACTN2 STAT5A STAT5B

5.95e-03287755IPR011992
DomainEGF_LAM_2

ATRN ATRNL1

6.44e-0330752PS50027
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.22e-045502M48987
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.22e-045502M48986
PathwayKEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.22e-045502M49006
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

1.83e-046502MM15581
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

1.83e-046502MM15621
PathwayREACTOME_STAT5_ACTIVATION

STAT5A STAT5B

2.56e-047502M27953
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.56e-047502M47581
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.56e-047502M47646
PathwayKEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.56e-047502M47430
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5

STAT5A STAT5B

2.56e-047502M27907
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

RANBP2 RNF213 EIF2AK3 STAT5A

3.24e-0493504M42521
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

4.37e-049502M27861
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

4.37e-049502MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

4.37e-049502M8066
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

5.45e-0410502M27898
PathwayREACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS

STAT5A STAT5B

5.45e-0410502M41731
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

5.45e-0410502MM15618
PathwayREACTOME_SIGNALING_BY_LEPTIN

STAT5A STAT5B

6.64e-0411502M27195
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

6.64e-0411502MM15578
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

7.95e-0412502M27893
PathwayREACTOME_SNRNP_ASSEMBLY

RANBP2 GEMIN5 SEC13

9.17e-0454503M29594
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

1.09e-0314502M27858
PathwayPID_IL5_PATHWAY

STAT5A STAT5B

1.09e-0314502M135
PathwayREACTOME_SNRNP_ASSEMBLY

RANBP2 GEMIN5 SEC13

1.13e-0358503MM14736
PathwayWP_FOXP3_IN_COVID19

STAT5A STAT5B

1.26e-0315502M42573
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

STAT5A STAT5B

1.26e-0315502M552
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B

1.26e-0315502MM1412
PathwayREACTOME_PENTOSE_PHOSPHATE_PATHWAY

PRPS2 DERA

1.26e-0315502M27682
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B

1.26e-0315502M17681
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B

1.26e-0315502MM14536
PathwayREACTOME_PENTOSE_PHOSPHATE_PATHWAY

PRPS2 DERA

1.26e-0315502MM15404
PathwayWP_MEASLES_VIRUS_INFECTION

APAF1 EIF2AK3 STAT5A STAT5B

1.35e-03136504M42547
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

STAT5A STAT5B

1.43e-0316502MM15710
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.43e-0316502M1296
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.43e-0316502MM1420
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

STAT5A STAT5B

1.43e-0316502M41733
PathwayWP_IL9_SIGNALING

STAT5A STAT5B

1.62e-0317502M39644
PathwayKEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.62e-0317502M47905
PathwayREACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS

STAT5A STAT5B

1.82e-0318502M673
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

STAT5A STAT5B

2.03e-0319502M41732
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B

2.03e-0319502M12836
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT5A STAT5B

2.25e-0320502MM15496
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B

2.25e-0320502MM1389
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

STAT5A STAT5B

2.25e-0320502M39002
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RANBP2 XPC SEC13

2.55e-0377503M27226
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

PRPS2 RANBP2 BPGM SEC13 DERA

2.65e-03271505MM15406
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B

2.72e-0322502M7747
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B

2.97e-0323502MM1411
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B

2.97e-0323502MM1424
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B

2.97e-0323502M7897
PathwayKEGG_MEDICUS_REFERENCE_IL2_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.97e-0323502M47904
PathwayREACTOME_GLUCOSE_METABOLISM

RANBP2 BPGM SEC13

3.05e-0382503MM15394
PathwayBIOCARTA_TPO_PATHWAY

STAT5A STAT5B

3.24e-0324502M11520
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

STAT5A STAT5B

3.24e-0324502M519
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RANBP2 XPC SEC13

3.27e-0384503MM14929
PathwayREACTOME_GLUCOSE_METABOLISM

RANBP2 BPGM SEC13

3.38e-0385503M1870
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

PRPS2 RANBP2 BPGM SEC13 DERA

3.44e-03288505M16864
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

STAT5A STAT5B

3.51e-0325502M41829
PathwayBIOCARTA_TPO_PATHWAY

STAT5A STAT5B

3.51e-0325502MM1519
PathwayREACTOME_SIGNALING_BY_ERYTHROPOIETIN

STAT5A STAT5B

3.51e-0325502M27865
PathwayWP_IL7_SIGNALING

STAT5A STAT5B

3.51e-0325502M39499
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT5A STAT5B

3.79e-0326502M27750
PathwayWP_EPO_RECEPTOR_SIGNALING

STAT5A STAT5B

3.79e-0326502M39687
PathwayPID_IL3_PATHWAY

STAT5A STAT5B

3.79e-0326502M182
PathwayWP_EPO_RECEPTOR_SIGNALING

STAT5A STAT5B

3.79e-0326502MM15896
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

SRRT RANBP2 FRY NF1 DSP CARMIL3 INPP4A TUBGCP3 KCNMA1 SEC13

8.77e-08475761031040226
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SRRT PACS1 EPRS1 RANBP2 CCNYL1 NF1 DSP SLCO4A1 GEMIN5 XPC PALB2 CCNY

1.14e-07774761215302935
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

KANSL1L RANBP2 DMXL2 DSP SYNE1 TUBGCP3 ABCF2 ACTN2 CDC42BPB

1.41e-0649776923414517
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SRRT PACS1 EPRS1 DMXL2 NF1 DSP INPP4A SYNE1 GEMIN5 ACTN2 CDC42BPB RPH3A WNK2 SEC13

2.36e-061431761437142655
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

4.71e-06276223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

4.71e-06276226999798
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

4.71e-06276220233708
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

4.71e-06276216775227
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

4.71e-06276231443474
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

4.71e-06276217447893
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

4.71e-06276212377952
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

4.71e-06276221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

4.71e-06276216289657
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

4.71e-06276225552366
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

4.71e-06276225470773
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

4.71e-06276221431790
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

4.71e-06276216115927
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

4.71e-06276223275557
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

4.71e-06276228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

4.71e-06276221826656
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

4.71e-06276211867689
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

4.71e-0627627720707
Pubmed

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

STAT5A STAT5B

4.71e-06276215980098
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

4.71e-06276227264955
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

4.71e-06276215340066
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

4.71e-06276222159083
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

4.71e-06276220008792
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

4.71e-06276233199496
Pubmed

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

STAT5A STAT5B

4.71e-06276223660011
Pubmed

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

STAT5A STAT5B

4.71e-06276212901872
Pubmed

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

STAT5A STAT5B

4.71e-06276228074064
Pubmed

STAT5b: A master regulator of key biological pathways.

STAT5A STAT5B

4.71e-06276236755813
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

4.71e-06276216502315
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

4.71e-06276212217382
Pubmed

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

STAT5A STAT5B

4.71e-06276225333863
Pubmed

A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.

STAT5A STAT5B

4.71e-06276212421978
Pubmed

A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.

STAT5A STAT5B

4.71e-0627629852045
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

4.71e-06276231599926
Pubmed

Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

STAT5A STAT5B

4.71e-06276219966185
Pubmed

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

STAT5A STAT5B

4.71e-06276221704724
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

4.71e-06276210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

4.71e-06276221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

4.71e-06276210486277
Pubmed

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

STAT5A STAT5B

4.71e-06276238618957
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

4.71e-06276216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

4.71e-06276215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

4.71e-06276230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

4.71e-06276223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

4.71e-06276232790723
Pubmed

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

STAT5A STAT5B

4.71e-0627628732682
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

4.71e-06276218492722
Pubmed

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5.

STAT5A STAT5B

4.71e-06276226717567
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

4.71e-06276210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

4.71e-06276210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

4.71e-06276235464049
Pubmed

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.

STAT5A STAT5B

4.71e-06276232281944
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

4.71e-06276218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

4.71e-06276223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

4.71e-0627628631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

4.71e-06276211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

4.71e-06276224878107
Pubmed

Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.

STAT5A STAT5B

4.71e-06276234818373
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

4.71e-06276212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

4.71e-06276212835478
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

4.71e-0627627568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

4.71e-06276224497979
Pubmed

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting.

STAT5A STAT5B

4.71e-06276223465551
Pubmed

STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells.

STAT5A STAT5B

4.71e-06276211756158
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

4.71e-06276217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

4.71e-06276217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

4.71e-06276217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

4.71e-06276210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

4.71e-06276217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

4.71e-06276224497923
Pubmed

IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice.

STAT5A STAT5B

4.71e-06276229203513
Pubmed

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia.

STAT5A STAT5B

4.71e-06276227367207
Pubmed

Genetic analysis of attractin homologs.

ATRN ATRNL1

4.71e-06276218064672
Pubmed

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

STAT5A STAT5B

4.71e-06276216493008
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

4.71e-06276224335105
Pubmed

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

STAT5A STAT5B

4.71e-0627628816482
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

4.71e-06276229460051
Pubmed

The role of STAT proteins in growth hormone signaling.

STAT5A STAT5B

4.71e-06276210851057
Pubmed

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

STAT5A STAT5B

4.71e-06276228806763
Pubmed

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

STAT5A STAT5B

4.71e-06276229105654
Pubmed

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

STAT5A STAT5B

4.71e-06276217003334
Pubmed

Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context.

STAT5A STAT5B

4.71e-06276217438530
Pubmed

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

STAT5A STAT5B

4.71e-06276215677477
Pubmed

A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.

STAT5A STAT5B

4.71e-06276216757175
Pubmed

Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression.

STAT5A STAT5B

4.71e-06276215677453
Pubmed

Haploinsufficiency identifies STAT5 as a modifier of IL-7-induced lymphomas.

STAT5A STAT5B

4.71e-06276215870688
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

4.71e-06276228606561
Pubmed

Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

STAT5A STAT5B

4.71e-06276219833766
Pubmed

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus.

STAT5A STAT5B

4.71e-06276217317776
Pubmed

Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis.

STAT5A STAT5B

4.71e-06276220415542
Pubmed

Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells.

STAT5A STAT5B

4.71e-06276223332799
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

4.71e-06276212393407
Pubmed

[Effect of STAT5 gene silencing on the proliferation of T lymphocytes in a mouse model of asthma].

STAT5A STAT5B

4.71e-06276222455944
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

4.71e-06276212039059
Pubmed

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.

STAT5A STAT5B

4.71e-06276232041920
Pubmed

STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.

STAT5A STAT5B

4.71e-06276217976521
GeneFamilyWD repeat domain containing

DMXL2 CFAP251 APAF1 GEMIN5 FBXW2 SEC13

1.02e-04262526362
GeneFamilyCyclins

CCNYL1 CCNY

2.92e-0328522473
GeneFamilyNucleoporins

RANBP2 SEC13

3.81e-03325221051
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ATRN ATRNL1

6.19e-03415221298
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 THSD4 PACS1 NF1 KCNMA1 CCNY

1.17e-0619976694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN SLC28A2 SCNN1A SLCO4A1 XPC

1.62e-0518576553854a9ec87c24c360541c83d86d8fafb303ad58
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN SLC28A2 SCNN1A SLCO4A1 XPC

1.62e-05185765a61fc7a3700a1efcf640bef7680c0443ee148a46
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CAPN13 THSD4 DSP SCNN1A WNK2

1.62e-05185765cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

STARD13 THSD4 FRY RAMP3 SYNE1

1.80e-05189765b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 PRPS2 SCNN1A SLCO4A1 GCGR

1.89e-051917655a5b5402a077b3189ca156f2bac5f47ad780aebf
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 PRPS2 SCNN1A SLCO4A1 GCGR

1.89e-0519176578bcce497920cc5b3bef083eab50deb1cc82cd2e
ToppCellfacs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 PRPS2 DSP SCNN1A TEX11

1.89e-05191765c06bbad24e4897b2c3b5015e4de02411ebf75367
ToppCellfacs-Lung-nan-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 PRPS2 DSP SCNN1A TEX11

1.89e-051917655f43f98cfe7a08d61ed55f34808fabfe47f1ac2e
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

INPP4A SYNE1 VPS13A RNF213 TEX11

1.99e-051937659337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

THSD4 FRY RAMP3 SYNE1 SLCO4A1

2.14e-051967654ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

CAPN13 DNAH3 DSP GCGR WNK2

2.25e-05198765e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

CAPN13 DNAH3 DSP GCGR WNK2

2.25e-05198765ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CAPN13 DSP SCNN1A SNX31 WNK2

2.36e-05200765ce969c958a31145bbfe315a9a865d7900ecc9549
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

CAPN13 DNAH3 TMEM232 DSP

1.30e-041517648216462e723fec2797387929dde095370947e10a
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STARD13 SLC28A2 SCNN1A MORC4

1.36e-041537640ef7c45cdd854c79e527006034029767f8e108b2
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 CCNYL1 SYNE1 WNK2

1.54e-0415876412661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 CCNYL1 SYNE1 WNK2

1.54e-04158764e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 CCNYL1 SYNE1 WNK2

1.54e-041587640792c39e6fc0745095af7812de2d50949540d60f
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM DMXL2 BPGM SCNN1A

1.82e-0416576484eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCellcontrol-Plasmablast|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TDRD15 KCNMA1 SLCO4A1 EIF2AK3

1.82e-0416576461063e0ce61bc92d5d1093be8279af03f650720b
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM DMXL2 BPGM SCNN1A

1.82e-04165764af59a095ecc6758abc13d763c00e44447c488167
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|343B / Donor, Lineage, Cell class and subclass (all cells)

MBOAT1 CARMIL3 SLC28A2 KCNMA1

1.91e-041677647efa0081e79f22b219eac64ffcaedb2179cde299
ToppCellClub_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

CAPN13 MGAM DSP WNK2

1.91e-04167764dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCelldroplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BPGM MBOAT1 SLC28A2 SCNN1A

1.95e-041687642201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM DMXL2 SYNE1 SCNN1A

2.00e-04169764a5964aef04093b460bbe29d5e2e7389f8fd2d46f
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM DMXL2 SYNE1 SCNN1A

2.00e-04169764e0076aa61b4ef3f836f5750005d0469d3982eb6d
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

THSD4 MGAM DMXL2 ACTN2

2.04e-041707644232fe937909f93d3736988c707b8f95ce993398
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FRY SYNE1 SCNN1A SLCO4A1

2.04e-04170764f0b0d2d0402de3ed7322284a599646db43475761
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FRY SYNE1 SCNN1A SLCO4A1

2.04e-04170764054360a3b05f5e41221c98b122d241b1affad26a
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FRY APAF1 CDC42BPB PALB2

2.28e-04175764334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

FRY APAF1 CDC42BPB PALB2

2.28e-04175764da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN13 SCNN1A KCNMA1 WNK2

2.38e-04177764a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN13 SCNN1A KCNMA1 WNK2

2.38e-04177764363e07b0f347f3716d530a28ead854b98e27d37c
ToppCellE18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

INPP4A SYNE1 VPS13A SLCO4A1

2.54e-04180764ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCellrenal_papilla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY ATRNL1 SLCO4A1

2.54e-0418076449829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCellE18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

INPP4A SYNE1 VPS13A SLCO4A1

2.54e-041807644e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCellHSPCs-Neutro_prog.|HSPCs / Lineage and Cell class

MGAM SLC28A2 SCNN1A XPC

2.54e-04180764328192f4678dcdc01c806362b225e770d23498d6
ToppCellE18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

INPP4A SYNE1 VPS13A SLCO4A1

2.54e-04180764466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD4 RAMP3 SYNE1 SLCO4A1

2.59e-04181764c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellHSPCs-Neutro_prog.|World / Lineage and Cell class

MGAM SLC28A2 SCNN1A XPC

2.65e-04182764f2512354b90f55bf4172c28084bf52cf79e41d8a
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPS2 SCNN1A SLCO4A1 GCGR

2.70e-0418376403c7e69136d5a3b9c5b2c91733e9b1c791f45c49
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MGAM RAMP3 SNX31

2.75e-0474763ef4c9eafc794c7d50aef28b37d21b52d3c511499
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MGAM RAMP3 SNX31

2.75e-04747636ecbdf4186039a031410e09ecd5afa66b6d5e2dc
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DMXL2 MBOAT1 VPS13A GEMIN5

2.76e-04184764a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DMXL2 MBOAT1 VPS13A GEMIN5

2.76e-04184764081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellControl-Myeloid_G-immature_Neutrophil|Control / Disease group, lineage and cell class

DMXL2 MBOAT1 VPS13A GEMIN5

2.76e-0418476445f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DMXL2 MBOAT1 VPS13A GEMIN5

2.76e-0418476484c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DMXL2 MBOAT1 VPS13A GEMIN5

2.76e-04184764d31d4116d1d196633784863781fa45673607a421
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

DMXL2 MBOAT1 VPS13A GEMIN5

2.76e-04184764ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellCiliated_cells-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CAPN13 DNAH3 CFAP251 TMEM232

2.76e-0418476407c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD4 FRY ACTN2 WNK2

2.82e-04185764549eeb521c3985bff396ea0f202db21822efa51f
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPS2 SCNN1A SLCO4A1 GCGR

2.82e-04185764af86e75096c1812ae27a78405355957ee8043d84
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 ATRNL1 SYNE1 KCNMA1

2.82e-04185764e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell5'-Adult-Distal_Rectal-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMXL2 CCNYL1 DSP WNK2

2.88e-041867644046b701aa29712d9f7c774f8955215122c3c003
ToppCellCOPD-Epithelial-Goblet|World / Disease state, Lineage and Cell class

CAPN13 DSP SCNN1A WNK2

2.88e-04186764d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMXL2 CCNYL1 DSP WNK2

2.88e-04186764bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRANK1 RAMP3 KCNMA1 RPH3A

2.88e-04186764d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RANBP2 GVINP1 INPP4A SYNE1

2.94e-04187764e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 ATRNL1 SYNE1 KCNMA1

3.00e-041887643177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RANBP2 NF1 RNF213 EIF2AK3

3.00e-04188764ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

THSD4 RAMP3 SYNE1 SLCO4A1

3.00e-04188764e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FRY DSP VPS13A ADCY7

3.00e-04188764beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP SCNN1A SLCO4A1 GCGR

3.00e-0418876414e120b20e76baa07b6510a94f0c2dcdfdd52357
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

THSD4 FRY ACTN2 WNK2

3.06e-041897649c1debd65c13d63fd4f3158917d621b44b714c26
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP SCNN1A SLCO4A1 GCGR

3.06e-04189764443359d90fafae0c1de6bdcce9e8c95df6ea4de8
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 ATRNL1 SYNE1 KCNMA1

3.06e-041897647ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 KANSL1L FRY SYNE1

3.06e-04189764830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellAdult|World / Lineage, Cell type, age group and donor

DMXL2 SCNN1A KCNMA1 RNF213

3.06e-041897645cd285bfad973125d46d704fec18b21266a63379
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPS2 SCNN1A GCGR RPH3A

3.12e-04190764c247562df3e1aa3173c9f01a74d5831f0764a1b2
ToppCellrenal_medulla_nuclei-Adult_normal_reference|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY SLCO4A1 CCNY

3.12e-04190764f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 FRY ATRNL1 KCNMA1

3.12e-0419076470c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPS2 SCNN1A GCGR RPH3A

3.12e-041907645cea8298c8336c136ba009630c9e48d4bc832cb2
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 MBOAT1 DSP SCNN1A

3.18e-04191764b94e66ac71e73f46b0323d424e7b8b906751d584
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 ATRNL1 SYNE1 KCNMA1

3.18e-0419176408042952431ca1a6fd7dfc13f36eb28643979598
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

THSD4 RAMP3 SYNE1 SLCO4A1

3.18e-04191764f229abf69a1217194f74b0502486907e07dba989
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FRY DSP SCNN1A ADCY7

3.18e-0419176463aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

DMXL2 KCNMA1 RNF213 ADCY7

3.24e-04192764a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH3 CFAP251 TMEM232 SYNE1

3.24e-04192764be592e661367affced9ebe80849b466e6adb3a34
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPS2 SCNN1A SLCO4A1 GCGR

3.24e-04192764e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

THSD4 FRY ACTN2 WNK2

3.24e-04192764ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPS2 SCNN1A SLCO4A1 GCGR

3.24e-0419276461c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCellCOPD-Epithelial-Goblet|COPD / Disease state, Lineage and Cell class

CAPN13 DSP SCNN1A WNK2

3.24e-0419276493b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCellfacs-Lung-nan-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 DSP SCNN1A TEX11

3.24e-04192764cca2d0fedfbd946c54d6f4fc45887117c8dae58a
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

ATRN EPRS1 RANBP2 RSF1

3.31e-04193764abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellClub_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CAPN13 DSP SCNN1A WNK2

3.31e-041937646582c0367052b9d10fb629c383ee0c55872afd2d
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH3 CFAP251 TMEM232 SYNE1

3.31e-04193764ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD4 RAMP3 SYNE1 SLCO4A1

3.31e-04193764979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH3 CFAP251 TMEM232 SYNE1

3.31e-041937640b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellClub_cells|World / lung cells shred on cell class, cell subclass, sample id

CAPN13 DSP SCNN1A WNK2

3.31e-041937649d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 CFAP251 TRANK1 ATRNL1

3.37e-0419476481713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

THSD4 BPGM GVINP1 SYNE1

3.37e-04194764777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

THSD4 FRY ACTN2 WNK2

3.37e-04194764c3535f7cc0076653c72db582047cff053c322397
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 CFAP251 TRANK1 ATRNL1

3.37e-04194764627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH3 CFAP251 TMEM232 SYNE1

3.44e-04195764fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

CAPN13 DNAH3 CFAP251 TMEM232

3.44e-0419576421dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCellproximal-Endothelial-Capillary_Aerocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FRY RAMP3 SLCO4A1 STAT5B

3.44e-04195764f1cbf82484f489fe7e0b5de6a49ea28d69f04e1a
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

THSD4 FRY ACTN2 WNK2

3.44e-0419576475fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellproximal-Endothelial-Capillary_Aerocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FRY RAMP3 SLCO4A1 STAT5B

3.44e-0419576413168c9632b58dd65ecb365df3832d95e7325919
ToppCellproximal-3-Endothelial-Capillary_Aerocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FRY RAMP3 SLCO4A1 STAT5B

3.44e-0419576436b2e754ed7ff138ac05fb51f4494e5339669828
Diseasecerebellar ataxia (implicated_via_orthology)

VPS13A GEMIN5

1.72e-048742DOID:0050753 (implicated_via_orthology)
Diseasearrhythmogenic right ventricular cardiomyopathy (is_implicated_in)

DSP ACTN2

2.76e-0410742DOID:0050431 (is_implicated_in)
Diseasecerebral cavernous malformation (implicated_via_orthology)

RNF213 CDC42BPB

3.36e-0411742DOID:0060669 (implicated_via_orthology)
DiseaseBasal cell carcinoma

XPC STAT5B

3.36e-0411742C0007117
DiseaseMoyamoya Disease

NF1 RNF213

8.24e-0417742C0026654
DiseaseUterine leiomyoma

SYNE1 KCNMA1 TEX11

1.57e-0391743HP_0000131
Diseasecolon adenocarcinoma (is_implicated_in)

STAT5A STAT5B

1.94e-0326742DOID:234 (is_implicated_in)
Diseasegastric adenocarcinoma (is_marker_for)

STAT5A STAT5B

2.25e-0328742DOID:3717 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
WDSWVLKAFDSQCQI

APAF1

246

O14727
EIQVWNWQLDKCIFL

APAF1

1026

O14727
WAIKDFQECTWQVVL

CATSPERG

36

Q6ZRH7
QEIWVCEKQTITKWP

ABCF2

581

Q9UG63
LCDLVWANEKAWFQT

CDY1

401

Q9Y6F8
KHGIVVDWDCVQDIW

ACTL7B

116

Q9Y614
WEKQQRKTFTAWCNS

ACTN2

36

P35609
WWKEIVATILFCIIA

EIF2AK3

521

Q9NZJ5
NQLWKKWVCDVSTTL

GVINP1

1891

Q7Z2Y8
CDCQTWKNWLQKITE

ANKIB1

476

Q9P2G1
WQCGQWVEVVIDDRL

CAPN13

131

Q6MZZ7
VWDDQAVWNVDYCQI

CCNY

226

Q8ND76
VLNDWKCVWQCKTSV

DMXL2

156

Q8TDJ6
LVFDAWTKAACAWEQ

ADCY7

111

P51828
EWIAPAFCQWFVKEI

CPO

111

Q8IVL8
VWDDQAVWNVDYCQI

CCNYL1

246

Q8N7R7
DAEVQKVCIWKWTLA

CFAP251

366

Q8TBY9
IVLICVWWQNGEWQA

RAET1E

241

Q8TD07
KQLCTERQKSWWDAV

RANBP2

521

P49792
VDVWKWCNLSEFIVY

RAMP3

51

O60896
EWEKVWLNVDKSLEC

INPP4A

526

Q96PE3
VAVNCSTEWKWLVDR

KANSL1L

361

A0AUZ9
ANDKLWFWLEVNSVV

KCNMA1

236

Q12791
VAAVVWKIKQSCWAS

ATRN

1296

O75882
CAVWWTKEFELFHNQ

MGAM

506

O43451
KWRNVTQEKSGWVEC

KIAA1109

636

Q2LD37
ERTEDVWQKIQWCLV

CARMIL3

646

Q8ND23
WLISEEEKTQKNQCW

FBXO3

61

Q9UK99
PWAVVKCLFENVQCW

GCGR

281

P47871
WVHQACLQRWVDEKQ

MARCHF5

41

Q9NX47
VLECSWDELWNKVQQ

TUBGCP3

726

Q96CW5
CKTEGWADQIVLQWE

LRRC42

301

Q9Y546
WNKENRFCSWVDQKL

BPGM

16

P07738
FEVWLEQATEIVKEW

PNMA2

181

Q9UL42
VAHWEAQIAEIIQWV

CDC42BPB

811

Q9Y5S2
VEWSDIKFFQLAAQW

PACS1

931

Q6VY07
CEDVVSLWKALDAWQ

PALB2

891

Q86YC2
IQDNLDAWLKCQATW

DNAH3

1076

Q8TD57
TQWSWILQITKCIDV

DSP

356

P15924
LVAAVVWKIKQTCWA

ATRNL1

1246

Q5VV63
LENWNIQTATWLKCV

MBOAT1

346

Q6ZNC8
DAWTYCISKNEWIQF

KLHDC2

296

Q9Y2U9
VWIFAQSVKDPWVLC

FRY

841

Q5TBA9
QWNKVISACTEVWQT

FBXW2

86

Q9UKT8
EVWQTACKNLGWQID

FBXW2

96

Q9UKT8
EWQAAWLLKAVTFID

DERA

41

Q9Y315
LIKICQEFNSTWAWE

RSF1

91

Q96T23
QVDWKDWKIGFQLCN

SCNN1A

216

P37088
VTLWKESVDGQWVCI

SEC13

286

P55735
LWDEDFVQWKVVETL

STARD13

976

Q9Y3M8
PIKLNQWCNVVRWEF

EPRS1

1141

P07814
WCVVLVLQVVQWKSE

TMEM179B

176

Q7Z7N9
SVWLCKICIEQREVW

RPH3A

136

Q9Y2J0
EWAVFSEKNKELCEW

SYNE1

7781

Q8NF91
KWIWFENSKNISFEC

TDRD15

1641

B5MCY1
VPDQTWVQCDECLKW

MORC4

421

Q8TE76
QSWCEKLAEIIWQNR

STAT5B

276

P51692
VQWVVQKVAWFLQIT

SLC28A2

281

O43868
EDSCWQWFVIYTKQA

SNX31

351

Q8N9S9
WVIDKACLLWQDQCG

SLCO4A1

636

Q96BD0
QSWCEKLAEIIWQNR

STAT5A

276

P42229
WVTFDRSVNIKEICW

SRRT

466

Q9BXP5
EKWQKSIVEELCAWV

RNF213

3181

Q63HN8
LEVVVERNLCWEWYQ

VPS13A

1291

Q96RL7
LENICLWKNWESIGE

ZNF519

76

Q8TB69
CKVDDFSWAWNVVYI

TMEM232

346

C9JQI7
VLQWIRENIAEWKNC

PRPS2

151

P11908
WLWAVEAFAKQLCFQ

GEMIN5

961

Q8TEQ6
AVINSLEKAFWNWVE

NF1

211

P21359
QWFRKTAWNLAVQCD

TEX11

636

Q8IYF3
TSDLACKLWVWQVEG

UNC5A

701

Q6ZN44
EDLICWQIWEQFTSK

ZNF233

101

A6NK53
EEWSCQQIWEQIAKD

ZNF155

96

Q12901
ETWVEVAWCELQDRK

WNK2

216

Q9Y3S1
WLEVFCEQEEKWVCV

XPC

531

Q01831
CQLKICSEWQIRTDW

THSD4

731

Q6ZMP0
WNEAFVAAKECLQWD

TRANK1

31

O15050
LSQEVLHCWQIWKQR

ZNF285

66

Q96NJ3
QWWECKFIAEGIIDQ

HECTD3

526

Q5T447