Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	EMILIN2 EMILIN1	3.09e-04	12	44	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	EMILIN2 EMILIN1	4.25e-04	14	44	2	GO:0097493
GeneOntologyBiologicalProcess	positive regulation of hemostasis	EMILIN2 EMILIN1 LPA	4.77e-05	31	47	3	GO:1900048
GeneOntologyBiologicalProcess	positive regulation of blood coagulation	EMILIN2 EMILIN1 LPA	4.77e-05	31	47	3	GO:0030194
GeneOntologyBiologicalProcess	positive regulation of coagulation	EMILIN2 EMILIN1 LPA	6.31e-05	34	47	3	GO:0050820
GeneOntologyCellularComponent	EMILIN complex	EMILIN2 EMILIN1	4.95e-06	2	47	2	GO:1990971
Domain	CUB	CUBN CSMD1 ADGRG6	1.81e-04	49	42	3	PF00431
Domain	CUB	CUBN CSMD1 ADGRG6	1.93e-04	50	42	3	SM00042
Domain	-	CUBN CSMD1 ADGRG6	2.16e-04	52	42	3	2.60.120.290
Domain	EMI	EMILIN2 EMILIN1	2.20e-04	10	42	2	PF07546
Domain	CUB	CUBN CSMD1 ADGRG6	2.29e-04	53	42	3	PS01180
Domain	CUB_dom	CUBN CSMD1 ADGRG6	2.84e-04	57	42	3	IPR000859
Domain	EMI_domain	EMILIN2 EMILIN1	5.81e-04	16	42	2	IPR011489
Domain	EMI	EMILIN2 EMILIN1	6.57e-04	17	42	2	PS51041
Domain	C1Q	EMILIN2 EMILIN1	2.35e-03	32	42	2	SM00110
Domain	C1q	EMILIN2 EMILIN1	2.35e-03	32	42	2	PF00386
Domain	C1q_dom	EMILIN2 EMILIN1	2.65e-03	34	42	2	IPR001073
Domain	C1Q	EMILIN2 EMILIN1	2.65e-03	34	42	2	PS50871
Domain	-	EMILIN2 EMILIN1	5.65e-03	50	42	2	2.60.120.40
Domain	Tumour_necrosis_fac-like_dom	EMILIN2 EMILIN1	7.54e-03	58	42	2	IPR008983
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PLEKHH1 CILK1 CACNA1H PLCG1 GNL3L PFKFB4 KIDINS220 CSMD1 MTA3 TCHP MAP4 ADGRG6	6.03e-07	1489	48	12	28611215
Pubmed	The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line.	IGKV1-12 IGKV1D-17 IGKV1D-12	1.65e-06	17	48	3	8223863
Pubmed	Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains.	EMILIN2 EMILIN1	1.87e-06	2	48	2	25445627
Pubmed	Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.	IGKV1-12 IGKV1D-12	1.87e-06	2	48	2	6776411
Pubmed	Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily.	EMILIN2 EMILIN1	1.87e-06	2	48	2	11278945
Pubmed	Cloning and characterization of 1116NS19.9 heavy and light chain cDNAs and expression of antibody fragments in Escherichia coli.	IGKV1-12 IGKV1D-12	1.87e-06	2	48	2	8372513
Pubmed	Variable region sequences of autoantibodies from mice with experimental systemic lupus erythematosus.	IGKV1-12 IGKV1D-12	1.87e-06	2	48	2	8325334
Pubmed	EMILIN2 regulates platelet activation, thrombus formation, and clot retraction.	EMILIN2 EMILIN1	1.87e-06	2	48	2	25658937
Pubmed	The EMILIN/Multimerin family.	EMILIN2 EMILIN1	1.87e-06	2	48	2	22566882
Pubmed	EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro.	EMILIN2 EMILIN1	5.59e-06	3	48	2	17988845
Pubmed	Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism.	IGKV1-12 IGKV1D-12	1.12e-05	4	48	2	6264318
Pubmed	Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family.	EMILIN2 EMILIN1	2.79e-05	6	48	2	14996434
Pubmed	Developmental expression and biochemical characterization of Emu family members.	EMILIN2 EMILIN1	3.90e-05	7	48	2	12221002
Pubmed	EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.	EMILIN2 EMILIN1	5.19e-05	8	48	2	32948785
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	EMILIN2 DPT EMILIN1 LPA	8.46e-05	167	48	4	22159717
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	MMP24 PLCG1	1.94e-04	15	48	2	17114464
Pubmed	Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.	FES PLCG1	2.21e-04	16	48	2	11071635
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	CIZ1 ACAD10 KIDINS220 MTA3 CAPN2	2.24e-04	400	48	5	35013556
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CIZ1 PLCG1 GNL3L KEAP1 MAP4 DEPDC1B VCPIP1	2.78e-04	934	48	7	33916271
Pubmed	Human myeloperoxidase in innate and acquired immunity.	IGKV1-12 IGKV1D-12	2.81e-04	18	48	2	20399194
Pubmed	Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function.	EMILIN2 EMILIN1	3.14e-04	19	48	2	28526753
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PLEKHH1 KIDINS220 MTA3	3.96e-04	103	48	3	10574462
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	PLEKHA1 KEAP1 KIDINS220 MAP4 DEPDC1B VCPIP1	4.13e-04	708	48	6	39231216
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	CIZ1 PLEKHA1 VCPIP1	4.31e-04	106	48	3	18654987
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	KIDINS220 MAP4 DEPDC1B VCPIP1	4.33e-04	256	48	4	33397691
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	KIDINS220 ATXN1L AGL	6.19e-04	120	48	3	21697133
Pubmed	Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.	MMP24 CFAP43	6.89e-04	28	48	2	18839057
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	DMXL2 PLCG1 MAP4	8.34e-04	133	48	3	15144186
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	EMILIN2 DPT EMILIN1	8.71e-04	135	48	3	28675934
Pubmed	Genome-wide association study of lung function decline in adults with and without asthma.	CSMD1 AGL	9.01e-04	32	48	2	22424883
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	PLEKHA1 KEAP1 KIDINS220 MAP4 VCPIP1	1.07e-03	565	48	5	25468996
Pubmed	Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.	FES KEAP1 MAP4 SHFL	1.11e-03	330	48	4	21044950
Pubmed	Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes.	IGKV1D-17 IGKV1D-12	1.14e-03	36	48	2	11298326
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	CIZ1 TCHP ATXN1L	1.23e-03	152	48	3	38360978
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	EMILIN2 DPT EMILIN1	1.25e-03	153	48	3	25037231
Cytoband	2p12	IGKV1-12 IGKV1D-17 IGKV1D-12	2.57e-04	117	48	3	2p12
Cytoband	Ensembl 112 genes in cytogenetic band chr2p11	IGKV1-12 IGKV1D-17 IGKV1D-12	1.46e-03	213	48	3	chr2p11
GeneFamily	EMI domain containing	EMILIN2 EMILIN1	5.19e-05	7	29	2	540
GeneFamily	Immunoglobulin kappa locus at 2p11.2	IGKV1-12 IGKV1D-17 IGKV1D-12	3.13e-04	83	29	3	351
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHH1 PLEKHA1 PLCG1	4.28e-03	206	29	3	682
GeneFamily	SH2 domain containing	FES PLCG1	1.14e-02	101	29	2	741
Disease	gamma wave measurement	SUPT20HL2 TCHP	2.07e-05	5	43	2	EFO_0008388
Disease	albuminuria	CUBN CSMD1 LPA	3.52e-04	94	43	3	EFO_0004285
Disease	sphingomyelin 22:0 measurement	CSMD1 TCHP	3.88e-04	20	43	2	EFO_0010395
Disease	body fat percentage, coronary artery disease	FES LPA	5.61e-04	24	43	2	EFO_0001645, EFO_0007800
Disease	diastolic blood pressure, alcohol drinking	FES ACAD10 FER1L5	6.85e-04	118	43	3	EFO_0004329, EFO_0006336
Disease	systolic blood pressure, body mass index	KEAP1 MAP4	1.13e-03	34	43	2	EFO_0004340, EFO_0006335
Disease	aspirin use measurement	ACAD10 LPA	1.49e-03	39	43	2	EFO_0007013

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFNPMNWRQLCLSSP	CFAP43	161	Q8NDM7
ATCRRNPLGMYQWDS	CSMD1	2471	Q96PZ7
NPLGMYQWDSLTPLC	CSMD1	2476	Q96PZ7
YPNSQACMWTLRAPT	ADGRG6	61	Q86SQ4
CLQMGLPPTENWNFY	ACAD10	536	Q6JQN1
ANWPNCSDLKQPMYL	DEPDC1B	251	Q8WUY9
RQWNYACMPTPQSLG	DPT	71	Q07507
NQTASNPKPYMSWQC	DMXL2	2836	Q8TDJ6
MNLRPPKSCGNVFYW	PKD1L1-AS1	26	Q9H7B7
PGYPRNILRDWMGCN	MMP24	556	Q9Y5R2
MQPPICVGLYAQWGS	KIDINS220	456	Q9ULH0
ENTPLYPICRAWMRN	LIN37	111	Q96GY3
YGMSPCNTAVVPQGW	MAP4	176	P27816
WFPGSRCDIQMTQSP	IGKV1D-12	16	P01611
ACWPAPSFQRYSMQG	ATXN1L	646	P0C7T5
SPEQWQRMYGRCSGN	KCNT1	526	Q5JUK3
MNGGVQTWTQPRLCY	PDZK1P1	1	A8MUH7
WMPYSNGRPALHACQ	PFKFB4	16	Q16877
WFPGARCNIQMTQSP	IGKV1D-17	16	A0A075B6S4
PWNPCELYQGMCRNA	DEFB116	36	Q30KQ4
MPCGGTYNATWTPQN	CUBN	3276	O60494
TMNYCRNPDADTGPW	LPA	1661	P08519
RNPDGDINGPWCYTM	LPA	1771	P08519
SALDCYNPMTNQWSP	KEAP1	391	Q14145
NQWSPCAPMSVPRNR	KEAP1	401	Q14145
WFPGSRCDIQMTQSP	IGKV1-12	16	A0A0C4DH73
AWGQPQCPQSIMYRR	EMILIN1	86	Q9Y6C2
WNQMPCPSALVYRVN	EMILIN2	76	Q9BXX0
LRMPCTLGWEAYTQP	CACNA1H	311	O95180
AGGCRNYPNTFWMNP	CAPN2	371	P17655
MWNERLGYILTCPSN	CKMT2	306	P17540
RLMEQCWAYEPGQRP	FES	791	P07332
YSWGPPNMQCRLCAI	MTA3	391	Q9BTC8
NPGYMIPCNCSAWPS	SOX21	231	Q9Y651
SYCQSGPFRWRDQMP	FER1L5	1591	A0AVI2
LTGYCTNPNRHQMGW	GNL3L	486	Q9NVN8
MSLQQNFSPCPRPWL	TMEM69	36	Q5SWH9
NTDPMEQCLQRYSWP	SUPT20HL2	231	P0C7V6
SSAMNFRWPQCVPNN	CILK1	231	Q9UPZ9
PPRRWCNTCQLYYMG	CIZ1	651	Q9ULV3
NFRGWAQMGSPSPCY	SHFL	161	Q9NUL5
CVNMRSLPWYVPANP	TTLL8	171	A6PVC2
CASMPWGDPNYRSAN	RNF114	176	Q9Y508
SNYDPLPMWICGSQL	PLCG1	1021	P19174
MALPTLPSYWCSQQR	TCHP	1	Q9BT92
LVPDYGMSNLTACNW	VCPIP1	526	Q96JH7
SCRPPQKYSLMQCWQ	PLEKHH1	906	Q9ULM0
RGMCEQSYWNPLEDP	TTC7B	271	Q86TV6
ATVPNYWDNPMVVCR	TBCCD1	436	Q9NVR7
WYMDNPQNLPSGSSR	PLEKHA1	41	Q9HB21
PWCDYQLRPNFTIAM	AGL	1371	P35573