Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	D-ribulose-phosphate 3-epimerase activity	RPEL1 RPE	9.49e-06	2	62	2	GO:0004750
GeneOntologyMolecularFunction	natural killer cell lectin-like receptor binding	RAET1G ULBP2 RAET1L	1.88e-05	17	62	3	GO:0046703
GeneOntologyMolecularFunction	racemase and epimerase activity, acting on carbohydrates and derivatives	RPEL1 RPE	5.12e-04	11	62	2	GO:0016857
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKA DGKD	5.12e-04	11	62	2	GO:0004143
GeneOntologyBiologicalProcess	positive regulation of type II interferon production	TYK2 ABL2 RAET1G ULBP2 RAET1L IL18R1	5.39e-07	103	60	6	GO:0032729
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	9.23e-07	61	60	5	GO:0034030
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	9.23e-07	61	60	5	GO:0034033
GeneOntologyBiologicalProcess	nucleoside bisphosphate biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	9.23e-07	61	60	5	GO:0033866
GeneOntologyBiologicalProcess	cellular response to dsRNA	RAET1G ULBP2 RIOK3 RAET1L	1.26e-06	28	60	4	GO:0071359
GeneOntologyBiologicalProcess	susceptibility to natural killer cell mediated cytotoxicity	RAET1G ULBP2 RAET1L	1.94e-06	9	60	3	GO:0042271
GeneOntologyBiologicalProcess	positive regulation of natural killer cell activation	TYK2 RAET1G ULBP2 RAET1L	3.17e-06	35	60	4	GO:0032816
GeneOntologyBiologicalProcess	regulation of type II interferon production	TYK2 ABL2 RAET1G ULBP2 RAET1L IL18R1	5.85e-06	155	60	6	GO:0032649
GeneOntologyBiologicalProcess	type II interferon production	TYK2 ABL2 RAET1G ULBP2 RAET1L IL18R1	9.61e-06	169	60	6	GO:0032609
GeneOntologyBiologicalProcess	thioester biosynthetic process	ACACA ACSBG1 HTD2 MLYCD	1.24e-05	49	60	4	GO:0035384
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	ACACA ACSBG1 HTD2 MLYCD	1.24e-05	49	60	4	GO:0071616
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	RAET1G ULBP2 RAET1L	1.28e-05	16	60	3	GO:0002486
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway	RAET1G ULBP2 RAET1L	1.55e-05	17	60	3	GO:0002484
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	RAET1G ULBP2 RAET1L	1.55e-05	17	60	3	GO:0002476
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class Ib	RAET1G ULBP2 RAET1L	1.85e-05	18	60	3	GO:0002428
GeneOntologyBiologicalProcess	regulation of natural killer cell activation	TYK2 RAET1G ULBP2 RAET1L	2.98e-05	61	60	4	GO:0032814
GeneOntologyBiologicalProcess	natural killer cell activation	TYK2 RAET1G ULBP2 RAET1L IL18R1	3.04e-05	124	60	5	GO:0030101
GeneOntologyBiologicalProcess	response to dsRNA	RAET1G ULBP2 RIOK3 RAET1L	3.39e-05	63	60	4	GO:0043331
GeneOntologyBiologicalProcess	cellular response to exogenous dsRNA	RAET1G ULBP2 RAET1L	3.46e-05	22	60	3	GO:0071360
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I	RAET1G ULBP2 RAET1L	3.98e-05	23	60	3	GO:0019885
GeneOntologyBiologicalProcess	positive regulation of chondrocyte differentiation	SOX6 SOX5 THRB	4.53e-05	24	60	3	GO:0032332
GeneOntologyBiologicalProcess	positive regulation of mesenchymal stem cell differentiation	SOX6 SOX5	4.97e-05	4	60	2	GO:2000741
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen	RAET1G ULBP2 RAET1L	5.14e-05	25	60	3	GO:0002483
GeneOntologyBiologicalProcess	antigen processing and presentation via MHC class Ib	RAET1G ULBP2 RAET1L	5.14e-05	25	60	3	GO:0002475
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate metabolic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	5.80e-05	142	60	5	GO:0034032
GeneOntologyBiologicalProcess	nucleoside bisphosphate metabolic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	5.80e-05	142	60	5	GO:0033865
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate metabolic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	5.80e-05	142	60	5	GO:0033875
GeneOntologyBiologicalProcess	positive regulation of T cell mediated immunity	RAET1G ULBP2 RAET1L IL18R1	6.39e-05	74	60	4	GO:0002711
GeneOntologyBiologicalProcess	fatty-acyl-CoA biosynthetic process	ACACA ACSBG1 HTD2	6.51e-05	27	60	3	GO:0046949
GeneOntologyBiologicalProcess	positive regulation of response to tumor cell	RAET1G ULBP2 RAET1L	7.28e-05	28	60	3	GO:0002836
GeneOntologyBiologicalProcess	positive regulation of immune response to tumor cell	RAET1G ULBP2 RAET1L	7.28e-05	28	60	3	GO:0002839
GeneOntologyBiologicalProcess	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	TYK2 RAET1G ULBP2 RAET1L IL18R1	7.53e-05	150	60	5	GO:0002824
GeneOntologyBiologicalProcess	positive regulation of adaptive immune response	TYK2 RAET1G ULBP2 RAET1L IL18R1	9.92e-05	159	60	5	GO:0002821
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous antigen	RAET1G ULBP2 RAET1L	1.09e-04	32	60	3	GO:0019883
GeneOntologyBiologicalProcess	malonyl-CoA metabolic process	ACACA MLYCD	1.24e-04	6	60	2	GO:2001293
GeneOntologyBiologicalProcess	somatic muscle development	NEB UTRN	1.24e-04	6	60	2	GO:0007525
GeneOntologyBiologicalProcess	pentose-phosphate shunt, non-oxidative branch	RPEL1 RPE	1.24e-04	6	60	2	GO:0009052
GeneOntologyBiologicalProcess	positive regulation of cartilage development	SOX6 SOX5 THRB	1.56e-04	36	60	3	GO:0061036
GeneOntologyBiologicalProcess	sulfur compound biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	1.68e-04	178	60	5	GO:0044272
GeneOntologyBiologicalProcess	positive regulation of natural killer cell mediated cytotoxicity	RAET1G ULBP2 RAET1L	2.14e-04	40	60	3	GO:0045954
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class I	RAET1G ULBP2 RAET1L	2.31e-04	41	60	3	GO:0002474
GeneOntologyBiologicalProcess	fatty-acyl-CoA metabolic process	ACACA ACSBG1 HTD2	2.48e-04	42	60	3	GO:0035337
GeneOntologyBiologicalProcess	positive regulation of T cell mediated cytotoxicity	RAET1G ULBP2 RAET1L	2.48e-04	42	60	3	GO:0001916
GeneOntologyBiologicalProcess	positive regulation of macrophage activation	RAET1G ULBP2 RAET1L	2.48e-04	42	60	3	GO:0043032
GeneOntologyBiologicalProcess	positive regulation of natural killer cell mediated immunity	RAET1G ULBP2 RAET1L	2.85e-04	44	60	3	GO:0002717
GeneOntologyBiologicalProcess	thioester metabolic process	ACACA ACSBG1 HTD2 MLYCD	2.87e-04	109	60	4	GO:0035383
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	ACACA ACSBG1 HTD2 MLYCD	2.87e-04	109	60	4	GO:0006637
GeneOntologyBiologicalProcess	regulation of T cell mediated immunity	RAET1G ULBP2 RAET1L IL18R1	3.07e-04	111	60	4	GO:0002709
GeneOntologyBiologicalProcess	regulation of immune response to tumor cell	RAET1G ULBP2 RAET1L	3.92e-04	49	60	3	GO:0002837
GeneOntologyBiologicalProcess	regulation of response to tumor cell	RAET1G ULBP2 RAET1L	4.16e-04	50	60	3	GO:0002834
GeneOntologyBiologicalProcess	lipid phosphorylation	DGKA DGKD	4.50e-04	11	60	2	GO:0046834
GeneOntologyBiologicalProcess	regulation of mesenchymal stem cell differentiation	SOX6 SOX5	4.50e-04	11	60	2	GO:2000739
GeneOntologyBiologicalProcess	fatty acid derivative biosynthetic process	ACACA ACSBG1 HTD2	4.67e-04	52	60	3	GO:1901570
GeneOntologyBiologicalProcess	regulation of T cell mediated cytotoxicity	RAET1G ULBP2 RAET1L	4.94e-04	53	60	3	GO:0001914
GeneOntologyBiologicalProcess	response to exogenous dsRNA	RAET1G ULBP2 RAET1L	5.51e-04	55	60	3	GO:0043330
GeneOntologyBiologicalProcess	purine ribonucleotide biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	5.69e-04	232	60	5	GO:0009152
GeneOntologyBiologicalProcess	immune response to tumor cell	RAET1G ULBP2 RAET1L	5.81e-04	56	60	3	GO:0002418
GeneOntologyBiologicalProcess	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	TYK2 RAET1G ULBP2 RAET1L IL18R1	6.03e-04	235	60	5	GO:0002822
GeneOntologyBiologicalProcess	transition between fast and slow fiber	GTF2IRD2B GTF2IRD2	6.36e-04	13	60	2	GO:0014883
GeneOntologyBiologicalProcess	regulation of chondrocyte differentiation	SOX6 SOX5 THRB	6.78e-04	59	60	3	GO:0032330
GeneOntologyBiologicalProcess	mesenchymal stem cell differentiation	SOX6 SOX5	7.40e-04	14	60	2	GO:0072497
GeneOntologyBiologicalProcess	ribonucleotide biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	7.55e-04	247	60	5	GO:0009260
GeneOntologyBiologicalProcess	regulation of adaptive immune response	TYK2 RAET1G ULBP2 RAET1L IL18R1	8.26e-04	252	60	5	GO:0002819
GeneOntologyBiologicalProcess	ribose phosphate biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	8.41e-04	253	60	5	GO:0046390
GeneOntologyBiologicalProcess	positive regulation of nitric oxide biosynthetic process	RAET1G ULBP2 RAET1L	8.99e-04	65	60	3	GO:0045429
GeneOntologyBiologicalProcess	positive regulation of lymphocyte mediated immunity	RAET1G ULBP2 RAET1L IL18R1	9.55e-04	150	60	4	GO:0002708
GeneOntologyBiologicalProcess	positive regulation of nitric oxide metabolic process	RAET1G ULBP2 RAET1L	9.82e-04	67	60	3	GO:1904407
GeneOntologyBiologicalProcess	acylglycerol metabolic process	CDK8 THRB DGKA DGKD	1.10e-03	156	60	4	GO:0006639
GeneOntologyBiologicalProcess	T cell mediated cytotoxicity	RAET1G ULBP2 RAET1L	1.12e-03	70	60	3	GO:0001913
GeneOntologyBiologicalProcess	neutral lipid metabolic process	CDK8 THRB DGKA DGKD	1.16e-03	158	60	4	GO:0006638
GeneOntologyBiologicalProcess	response to tumor cell	RAET1G ULBP2 RAET1L	1.16e-03	71	60	3	GO:0002347
GeneOntologyBiologicalProcess	T cell mediated immunity	RAET1G ULBP2 RAET1L IL18R1	1.30e-03	163	60	4	GO:0002456
GeneOntologyBiologicalProcess	purine nucleotide biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	1.32e-03	280	60	5	GO:0006164
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen	RAET1G ULBP2 RAET1L	1.41e-03	76	60	3	GO:0048002
GeneOntologyBiologicalProcess	regulation of natural killer cell mediated cytotoxicity	RAET1G ULBP2 RAET1L	1.41e-03	76	60	3	GO:0042269
GeneOntologyBiologicalProcess	purine-containing compound biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	1.50e-03	288	60	5	GO:0072522
GeneOntologyBiologicalProcess	positive regulation of cytokine production	TYK2 ABL2 RAET1G ULBP2 RIOK3 RAET1L IL18R1	1.51e-03	586	60	7	GO:0001819
GeneOntologyBiologicalProcess	regulation of skeletal muscle adaptation	GTF2IRD2B GTF2IRD2	1.53e-03	20	60	2	GO:0014733
GeneOntologyBiologicalProcess	positive regulation of leukocyte mediated cytotoxicity	RAET1G ULBP2 RAET1L	1.58e-03	79	60	3	GO:0001912
GeneOntologyBiologicalProcess	amide biosynthetic process	ACACA ACSBG1 HTD2 MLYCD	1.58e-03	172	60	4	GO:0043604
GeneOntologyBiologicalProcess	regulation of natural killer cell mediated immunity	RAET1G ULBP2 RAET1L	1.64e-03	80	60	3	GO:0002715
GeneOntologyBiologicalProcess	positive regulation of leukocyte mediated immunity	RAET1G ULBP2 RAET1L IL18R1	1.69e-03	175	60	4	GO:0002705
GeneOntologyBiologicalProcess	regulation of cartilage development	SOX6 SOX5 THRB	1.70e-03	81	60	3	GO:0061035
GeneOntologyBiologicalProcess	regulation of macrophage activation	RAET1G ULBP2 RAET1L	1.70e-03	81	60	3	GO:0043030
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	ACACA ACSBG1 HTD2	1.76e-03	82	60	3	GO:1901568
GeneOntologyBiologicalProcess	glyceraldehyde-3-phosphate metabolic process	RPEL1 RPE	1.85e-03	22	60	2	GO:0019682
GeneOntologyBiologicalProcess	pentose-phosphate shunt	RPEL1 RPE	1.85e-03	22	60	2	GO:0006098
GeneOntologyBiologicalProcess	cartilage condensation	SOX6 SOX5	2.02e-03	23	60	2	GO:0001502
GeneOntologyBiologicalProcess	purine nucleotide metabolic process	ACACA ACSBG1 HTD2 RPEL1 PAPSS2 RPE MLYCD	2.06e-03	619	60	7	GO:0006163
GeneOntologyBiologicalProcess	positive regulation of cell killing	RAET1G ULBP2 RAET1L	2.15e-03	88	60	3	GO:0031343
GeneOntologyBiologicalProcess	fatty acid biosynthetic process	ACACA ACSBG1 HTD2 MLYCD	2.32e-03	191	60	4	GO:0006633
GeneOntologyBiologicalProcess	nucleotide biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	2.34e-03	319	60	5	GO:0009165
GeneOntologyBiologicalProcess	nucleoside phosphate biosynthetic process	ACACA ACSBG1 HTD2 PAPSS2 MLYCD	2.37e-03	320	60	5	GO:1901293
GeneOntologyBiologicalProcess	NADPH regeneration	RPEL1 RPE	2.39e-03	25	60	2	GO:0006740
GeneOntologyBiologicalProcess	organophosphate biosynthetic process	ACACA ACSBG1 HTD2 DGKA DGKD PAPSS2 MLYCD	2.58e-03	644	60	7	GO:0090407
GeneOntologyBiologicalProcess	purine-containing compound metabolic process	ACACA ACSBG1 HTD2 RPEL1 PAPSS2 RPE MLYCD	2.76e-03	652	60	7	GO:0072521
GeneOntologyBiologicalProcess	cell aggregation	SOX6 SOX5	2.79e-03	27	60	2	GO:0098743
GeneOntologyBiologicalProcess	positive regulation of stem cell differentiation	SOX6 SOX5	2.79e-03	27	60	2	GO:2000738
GeneOntologyBiologicalProcess	regulation of nitric oxide biosynthetic process	RAET1G ULBP2 RAET1L	2.84e-03	97	60	3	GO:0045428
Domain	Ribul_P_3_epim	RPEL1 RPE	1.12e-05	2	63	2	PF00834
Domain	RIBUL_P_3_EPIMER_1	RPEL1 RPE	1.12e-05	2	63	2	PS01085
Domain	Ribul_P_3_epim	RPEL1 RPE	1.12e-05	2	63	2	IPR026019
Domain	Ribul_P_3_epim-like	RPEL1 RPE	1.12e-05	2	63	2	IPR000056
Domain	RibuloseP-bd_barrel	RPEL1 RPE	3.35e-05	3	63	2	IPR011060
Domain	MHC_I	RAET1G ULBP2 RAET1L	4.66e-05	21	63	3	PF00129
Domain	MHC_I_a_a1/a2	RAET1G ULBP2 RAET1L	4.66e-05	21	63	3	IPR001039
Domain	-	GTF2IRD2B GTF2IRD2	6.69e-05	4	63	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	6.69e-05	4	63	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	6.69e-05	4	63	2	PF02946
Domain	GTF2I	GTF2IRD2B GTF2IRD2	6.69e-05	4	63	2	IPR004212
Domain	-	RAET1G ULBP2 RAET1L	7.04e-05	24	63	3	3.30.500.10
Domain	MHC_I-like_Ag-recog	RAET1G ULBP2 RAET1L	7.04e-05	24	63	3	IPR011161
Domain	MHC_I/II-like_Ag-recog	RAET1G ULBP2 RAET1L	2.84e-04	38	63	3	IPR011162
Domain	DAGK_acc	DGKA DGKD	4.95e-04	10	63	2	PF00609
Domain	Diacylglycerol_kin_accessory	DGKA DGKD	4.95e-04	10	63	2	IPR000756
Domain	DAGKa	DGKA DGKD	4.95e-04	10	63	2	SM00045
Domain	DAGKc	DGKA DGKD	9.93e-04	14	63	2	SM00046
Domain	IG_MHC	RAET1G ULBP2 RAET1L	1.09e-03	60	63	3	PS00290
Domain	Diacylglycerol_kinase_cat_dom	DGKA DGKD	1.14e-03	15	63	2	IPR001206
Domain	DAGK_cat	DGKA DGKD	1.14e-03	15	63	2	PF00781
Domain	DAGK	DGKA DGKD	1.14e-03	15	63	2	PS50146
Domain	NAD/diacylglycerol_kinase	DGKA DGKD	1.47e-03	17	63	2	IPR016064
Domain	RNaseH-like_dom	GTF2IRD2B EXD1 GTF2IRD2	1.64e-03	69	63	3	IPR012337
Domain	-	ACACA RBP3	2.26e-03	21	63	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	ACACA RBP3	2.26e-03	21	63	2	IPR029045
Domain	tRNA-bd_arm	SOX6 SOX5	2.95e-03	24	63	2	IPR010978
Domain	AMP-binding	DIP2B ACSBG1	4.58e-03	30	63	2	PF00501
Domain	AMP-dep_Synth/Lig	DIP2B ACSBG1	4.58e-03	30	63	2	IPR000873
Domain	Gal_Oxidase_b-propeller	KLHL2 GAN	5.86e-03	34	63	2	IPR015916
Domain	-	RPEL1 RPE	8.84e-03	42	63	2	3.20.20.70
Domain	BTB-kelch_protein	KLHL2 GAN	9.25e-03	43	63	2	IPR017096
Domain	Aldolase_TIM	RPEL1 RPE	9.67e-03	44	63	2	IPR013785
Pubmed	Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.	RAET1G ULBP2 RAET1L	6.23e-09	3	65	3	25212604
Pubmed	NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.	RAET1G ULBP2 RAET1L	2.49e-08	4	65	3	12756263
Pubmed	Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.	RAET1G ULBP2 RAET1L	2.49e-08	4	65	3	20166740
Pubmed	Murine NKG2D ligands: "double, double toil and trouble".	RAET1G ULBP2 RAET1L	2.49e-08	4	65	3	19081632
Pubmed	Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules.	RAET1G ULBP2 RAET1L	2.49e-08	4	65	3	8882725
Pubmed	Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin.	RAET1G ULBP2 RAET1L	2.49e-08	4	65	3	12421908
Pubmed	MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activation.	RAET1G ULBP2 RAET1L	6.21e-08	5	65	3	24572784
Pubmed	Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain.	RAET1G ULBP2 RAET1L	6.21e-08	5	65	3	8982867
Pubmed	Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D.	RAET1G ULBP2 RAET1L	1.24e-07	6	65	3	11825567
Pubmed	Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.	RAET1G ULBP2 RAET1L	1.24e-07	6	65	3	20219610
Pubmed	Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.	RAET1G ULBP2 RAET1L	1.24e-07	6	65	3	10894171
Pubmed	Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.	RAET1G ULBP2 RAET1L	1.24e-07	6	65	3	19688209
Pubmed	The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation.	RAET1G ULBP2 RAET1L	1.24e-07	6	65	3	20976056
Pubmed	Ligands for murine NKG2D display heterogeneous binding behavior.	RAET1G ULBP2 RAET1L	1.24e-07	6	65	3	11857333
Pubmed	The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.	RAET1G ULBP2 RAET1L	2.17e-07	7	65	3	16831899
Pubmed	Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase.	RAET1G ULBP2 RAET1L	2.17e-07	7	65	3	20870941
Pubmed	Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma.	RAET1G ULBP2 RAET1L	2.17e-07	7	65	3	26151313
Pubmed	NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.	RAET1G ULBP2 RAET1L	2.17e-07	7	65	3	30787931
Pubmed	Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.	RAET1G ULBP2 RAET1L	2.17e-07	7	65	3	12370332
Pubmed	NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.	RAET1G ULBP2 RAET1L	2.17e-07	7	65	3	25583577
Pubmed	A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity.	RAET1G ULBP2 RAET1L	3.47e-07	8	65	3	12645935
Pubmed	Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells.	RAET1G ULBP2 RAET1L	5.19e-07	9	65	3	23136011
Pubmed	Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor.	RAET1G ULBP2 RAET1L	5.19e-07	9	65	3	14764662
Pubmed	A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.	RAET1G ULBP2 RAET1L	7.41e-07	10	65	3	11827464
Pubmed	Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles.	RAET1G ULBP2 RAET1L	1.02e-06	11	65	3	26656785
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	3.44e-06	2	65	2	15388857
Pubmed	Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing.	SOX6 SOX5	3.44e-06	2	65	2	11585348
Pubmed	Generation of mice harboring a Sox5 conditional null allele.	SOX6 SOX5	3.44e-06	2	65	2	18543318
Pubmed	SoxD genes are required for adult neural stem cell activation.	SOX6 SOX5	1.03e-05	3	65	2	35108528
Pubmed	Generation of mice harboring a Sox6 conditional null allele.	SOX6 SOX5	1.03e-05	3	65	2	16652367
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	1.03e-05	3	65	2	15100712
Pubmed	Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart.	ACACA MLYCD	1.03e-05	3	65	2	18614968
Pubmed	The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage.	SOX6 SOX5	1.03e-05	3	65	2	15529345
Pubmed	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	RPEL1 RPE	1.03e-05	3	65	2	7396409
Pubmed	SOX trio decrease in the articular cartilage with the advancement of osteoarthritis.	SOX6 SOX5	1.03e-05	3	65	2	21728837
Pubmed	The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.	SOX6 SOX5	1.03e-05	3	65	2	26150426
Pubmed	SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells.	SOX6 SOX5	1.03e-05	3	65	2	28687615
Pubmed	Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells.	SOX6 SOX5	1.03e-05	3	65	2	21401405
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA MLYCD	1.03e-05	3	65	2	17210641
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	FANCB ACACA SPO11	1.57e-05	26	65	3	23435420
Pubmed	Dynamic epigenetic mechanisms regulate age-dependent SOX9 expression in mouse articular cartilage.	SOX6 SOX5	2.06e-05	4	65	2	26806292
Pubmed	L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer.	SOX6 SOX5	2.06e-05	4	65	2	18559420
Pubmed	miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.	SOX6 SOX5	2.06e-05	4	65	2	32960357
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2B GTF2IRD2	2.06e-05	4	65	2	21328569
Pubmed	Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.	SOX6 SOX5	2.06e-05	4	65	2	19759178
Pubmed	Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain.	RAET1G ULBP2	2.06e-05	4	65	2	19424970
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2B GTF2IRD2	2.06e-05	4	65	2	17823943
Pubmed	Evolution of general transcription factors.	GTF2IRD2B GTF2IRD2	2.06e-05	4	65	2	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2B GTF2IRD2	2.06e-05	4	65	2	22899722
Pubmed	SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer.	SOX6 SOX5	2.06e-05	4	65	2	21262861
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	JCAD DIP2B PHLDB1 ABL2 ACACA AHNAK GAN KLC4 UTRN	3.10e-05	861	65	9	36931259
Pubmed	ULBP6/RAET1L is an additional human NKG2D ligand.	RAET1G RAET1L	3.43e-05	5	65	2	19658097
Pubmed	The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.	SOX6 SOX5	3.43e-05	5	65	2	20940257
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACA MLYCD	3.43e-05	5	65	2	37163372
Pubmed	Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development.	SOX6 SOX5	3.43e-05	5	65	2	16627753
Pubmed	L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.	SOX6 SOX5	5.13e-05	6	65	2	22547066
Pubmed	The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells.	RPEL1 RPE	5.13e-05	6	65	2	5360673
Pubmed	A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.	SOX6 SOX5	5.13e-05	6	65	2	9755172
Pubmed	Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.	THRB SIN3A	5.13e-05	6	65	2	10207062
Pubmed	Runx1 and Runx2 cooperate during sternal morphogenesis.	SOX6 SOX5	7.18e-05	7	65	2	20181744
Pubmed	A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.	ULBP2 RAET1L	7.18e-05	7	65	2	28559451
Pubmed	Pairing SOX off: with partners in the regulation of embryonic development.	SOX6 SOX5	7.18e-05	7	65	2	10729834
Pubmed	The transcription factor Sox5 modulates Sox10 function during melanocyte development.	SOX6 SOX5	9.56e-05	8	65	2	18703590
Pubmed	Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.	TYK2 IL18R1	9.56e-05	8	65	2	19249008
Pubmed	Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.	SOX6 SOX5	9.56e-05	8	65	2	26345464
Pubmed	A conserved family of genes related to the testis determining gene, SRY.	SOX6 SOX5	9.56e-05	8	65	2	1614875
Pubmed	Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.	CDK8 SIN3A	1.23e-04	9	65	2	9150135
Pubmed	Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.	THRB SIN3A	1.23e-04	9	65	2	10944117
Pubmed	An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos.	SOX6 SOX5	1.23e-04	9	65	2	28630873
Pubmed	Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.	SOX6 SOX5	1.23e-04	9	65	2	30008325
Pubmed	Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.	SOX6 SOX5	1.53e-04	10	65	2	15096597
Pubmed	From head to toes: the multiple facets of Sox proteins.	SOX6 SOX5	1.53e-04	10	65	2	10037800
Pubmed	Sox9 is required for notochord maintenance in mice.	SOX6 SOX5	1.87e-04	11	65	2	16678811
Pubmed	Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.	SV2B UTRN	1.87e-04	11	65	2	12403715
Pubmed	Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.	RPEL1 RPE	1.87e-04	11	65	2	9119401
Pubmed	Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.	SOX6 SOX5	1.87e-04	11	65	2	15781876
Pubmed	Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.	SOX6 SOX5	1.87e-04	11	65	2	17470636
Pubmed	Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.	DGKA DGKD	1.87e-04	11	65	2	17021016
Pubmed	Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.	SOX6 SOX5	2.24e-04	12	65	2	26525805
Pubmed	miRNAs control tracheal chondrocyte differentiation.	SOX6 SOX5	2.24e-04	12	65	2	21945074
Pubmed	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system.	SOX6 SOX5	2.24e-04	12	65	2	34234180
Pubmed	Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development.	SOX6 SOX5	2.65e-04	13	65	2	15634692
Pubmed	Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.	SOX6 SOX5	2.65e-04	13	65	2	22735158
Pubmed	SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors.	SOX6 SOX5	2.65e-04	13	65	2	23884650
Pubmed	HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.	SOX6 SOX5	2.65e-04	13	65	2	27160681
Pubmed	Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.	SOX6 SOX5	3.08e-04	14	65	2	8921394
Pubmed	Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate.	SOX6 SOX5	3.56e-04	15	65	2	14993235
Pubmed	Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development.	SOX6 SOX5	3.56e-04	15	65	2	26890219
Pubmed	Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage.	SOX6 SOX5	3.56e-04	15	65	2	20206616
Pubmed	Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors.	TCERG1L THRB	3.56e-04	15	65	2	31260032
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX6 SOX5	3.56e-04	15	65	2	30871468
Pubmed	Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.	SOX6 SOX5	4.06e-04	16	65	2	17222543
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	AHNAK NEB	4.06e-04	16	65	2	24960163
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	FANCB SPO11	4.06e-04	16	65	2	27760317
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 TYK2 DIP2B PHLDB1 DNAJC13 THRB ACACA METTL15 UTRN TBCD	4.20e-04	1489	65	10	28611215
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX6 SOX5	4.59e-04	17	65	2	27241892
Pubmed	Musculoskeletal integration at the wrist underlies the modular development of limb tendons.	SOX6 SOX5	4.59e-04	17	65	2	26062940
Pubmed	Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.	PHLDB1 DGKA	4.59e-04	17	65	2	22951725
Pubmed	Cbfb regulates bone development by stabilizing Runx family proteins.	SOX6 SOX5	4.59e-04	17	65	2	25262822
Pubmed	Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.	SOX6 SOX5	5.16e-04	18	65	2	29899135
Cytoband	Ensembl 112 genes in cytogenetic band chr6q25	RAET1G NUP43 ULBP2 RAET1L	8.97e-05	164	65	4	chr6q25
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKA DGKD	1.62e-04	10	35	2	1178
GeneFamily	SRY-boxes	SOX6 SOX5	6.10e-04	19	35	2	757
GeneFamily	Kelch like\|BTB domain containing	KLHL2 GAN	2.99e-03	42	35	2	617
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC13 DNAJC12	4.04e-03	49	35	2	584
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000	SOX5 KLHL2 DNAJC13 ABL2 EXD1 SPO11 GAN DGKD NEB UTRN	5.08e-05	778	59	10	gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000	ZYG11A FANCB DNAJC13 ABL2 EXD1 NUP43 DGKA SPO11 SIN3A ESPL1	6.09e-05	795	59	10	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_DevVasTestis_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	DNAJC13 ABL2 DGKA	1.36e-04	36	59	3	gudmap_dev gonad_e12.5_M_gudmap_devVasTestis_Flk_k3_1000
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	DNAJC13 ABL2 DGKA	1.36e-04	36	59	3	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_k3_1000
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	SOX6 JCAD SIAE PHLDB1 ACSBG1 GAN DGKD CCDC160 PAPSS2 ATP8B2	1.41e-04	880	59	10	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
CoexpressionAtlas	ratio_StemCell_vs_induced-Mesoderm_top-relative-expression-ranked_500_k-means-cluster#2	THRB ACSBG1 DNAJC12	1.73e-04	39	59	3	ratio_SC_vs_MESO_500_K2
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#4_top-relative-expression-ranked_500	ZYG11A DNAJC13 ABL2 ESPL1	1.80e-04	101	59	4	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k4_500
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000	SOX5 DNAJC13 ABL2 EXD1 SPO11 GAN DGKD UTRN EPM2AIP1	2.71e-04	776	59	9	gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	ZYG11A FANCB DNAJC13 ABL2 SIN3A ESPL1	3.18e-04	333	59	6	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000	SOX5 SIAE DNAJC13 ABL2 EXD1 SPO11 GAN UTRN EPM2AIP1	3.24e-04	795	59	9	gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000	ZYG11A FANCB DNAJC13 ABL2 NUP43 SPO11 SIN3A CCDC160 ESPL1	3.36e-04	799	59	9	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	ZYG11A FANCB DNAJC13 ABL2 EXD1 DGKA SPO11 SIN3A ESPL1	3.71e-04	810	59	9	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#4_top-relative-expression-ranked_1000	JCAD DIP2B UTRN	3.86e-04	51	59	3	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k4_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	ZYG11A FANCB DNAJC13 ABL2 ACACA EXD1 SPO11 DGKD ESPL1	4.06e-04	820	59	9	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
ToppCell	21-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	PCSK2 TCERG1L SV2B DNAJC12 NEB ESPL1	3.31e-07	188	65	6	e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell	15-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	PCSK2 TCERG1L DNAJC12 NEB ESPL1 TNR	3.63e-07	191	65	6	76311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PCSK2 TCERG1L SV2B DNAJC12 ESPL1	6.59e-06	180	65	5	57689ccbbd44c0e78e061edd87d3102c5f2dcc9a
ToppCell	facs-Marrow-T-cells-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD22 AHNAK DGKA DGKD IL18R1	7.53e-06	185	65	5	e1fd0a807def8c2127194108b1a30c6de7024292
ToppCell	18-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	PCSK2 TCERG1L SV2B DNAJC12 ESPL1	7.53e-06	185	65	5	f8fc7b12b4e18d23d84e95488be93c4352d325f3
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 AHNAK DGKA IL18R1 UTRN	7.73e-06	186	65	5	4dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 AHNAK DGKA IL18R1 UTRN	7.73e-06	186	65	5	e23e1246914e230369a716d0d666b98383bf8512
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCERG1L SV2B DNAJC12 NEB ESPL1	8.14e-06	188	65	5	1f912ea015f50570e848259d948a0ba682d64bb4
ToppCell	18-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	PCSK2 TCERG1L SV2B DNAJC12 ESPL1	8.35e-06	189	65	5	144beb01b908f2cd0e04513fb84d817e0c3c124e
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCERG1L SV2B DNAJC12 NEB ESPL1	8.57e-06	190	65	5	40d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCERG1L SV2B DNAJC12 NEB ESPL1	8.57e-06	190	65	5	f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCERG1L SV2B DNAJC12 NEB ESPL1	8.57e-06	190	65	5	a9a705455019e28d655636de73b07540798f82e6
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	SOX5 DIP2B THRB ACACA UTRN	1.07e-05	199	65	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FANCB TCERG1L EXD1 ATP8B2	7.04e-05	151	65	4	d19fc363ba1d7ff77e0adcaacafa4c64e1143f40
ToppCell	facs-Marrow-B-cells-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 ACACA GTF2IRD2 IL18R1	1.02e-04	166	65	4	13027ae342994db4540e64eb910df1f42b160931
ToppCell	facs-Marrow-B-cells-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 ACACA GTF2IRD2 IL18R1	1.02e-04	166	65	4	b21e45bd43f26149b9cd6e45c19241c82d54fb2f
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 AHNAK DGKA IL18R1	1.06e-04	168	65	4	110c3c7c322e04a684a19c2b5434a502279fd000
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 AHNAK DGKA IL18R1	1.06e-04	168	65	4	735d30cfda1889740bdeb43e39330a52e8f4d599
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PCSK2 TCERG1L SV2B DNAJC12	1.09e-04	169	65	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DGKA SPO11 IL18R1 UTRN	1.14e-04	171	65	4	a8adce007ff4c713f71f2359b40cb3575b28c98d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DGKA NEB IL18R1	1.14e-04	171	65	4	8719a18c9e6b6f5d8ec4e937c2bda1e36441c9ec
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PCSK2 TCERG1L SV2B DNAJC12	1.14e-04	171	65	4	b7cddb8f726a43fb8a37f3e67a3f722e2178fd7a
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DGKA NEB IL18R1	1.14e-04	171	65	4	f4cdd7862c8fe99ee765a2f3ed375b584f4976c5
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TYK2 ACSBG1 METTL15 MLYCD	1.19e-04	173	65	4	b6bb2a136a40f0946bbcde8d5972d3f059d080c7
ToppCell	facs-Marrow-T-cells\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD22 AHNAK DGKA IL18R1	1.19e-04	173	65	4	806f94f5c3ac836ddffc389d3c2cd7e4da7a608d
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX5 CD22 NEB MLYCD	1.22e-04	174	65	4	59ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DGKA SDF4 UTRN	1.22e-04	174	65	4	919fc124affc69acfd8f575f2c372674f3d2625e
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACSBG1 DGKA NEB IL18R1	1.24e-04	175	65	4	3bdccb4037053795d62ab5b6fcc09cdd406f9b50
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACSBG1 DGKA NEB IL18R1	1.24e-04	175	65	4	770546ddaa49ee482c4c7577ab76efbc6c304a29
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABL2 THRB ABCA5 KLC4	1.27e-04	176	65	4	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 AHNAK IL18R1 UTRN	1.30e-04	177	65	4	dba8b30a311051c22ca5f77697f5dbf9423c3ba0
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 AHNAK IL18R1 UTRN	1.30e-04	177	65	4	6561794ae3b14b5279b249eb5e93b80ef15ed82c
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 PCSK2 JCAD AHNAK	1.39e-04	180	65	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 PCSK2 JCAD AHNAK	1.39e-04	180	65	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	PCSK2 TCERG1L SV2B DNAJC12	1.45e-04	182	65	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCSK2 JCAD KLHL2 SV2B	1.57e-04	186	65	4	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCSK2 TCERG1L SV2B ESPL1	1.57e-04	186	65	4	fcabebdfbf1b1dbb35ce2b3c53a60d2b1aed8e6c
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCSK2 TCERG1L SV2B DNAJC12	1.57e-04	186	65	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCSK2 TCERG1L SV2B DNAJC12	1.64e-04	188	65	4	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TCERG1L DNAJC12 NEB ESPL1	1.74e-04	191	65	4	146cfd4daa2878536b4f381564c787919ad855a8
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TCERG1L DNAJC12 NEB ESPL1	1.74e-04	191	65	4	12ea07565dc0e62cade9fbab4a2d763e47a341e3
ToppCell	control-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ABCA5 CD22 IL18R1 ATP8B2	1.74e-04	191	65	4	afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	PCSK2 SIAE THRB ACACA	1.78e-04	192	65	4	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SOX5 CD22 NEB CCDC144A	1.78e-04	192	65	4	24797e80b1f5b3ea5a0410caaf57ccf2ae9d716e
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TCERG1L DNAJC12 NEB ESPL1	1.81e-04	193	65	4	25b1e5a04724023918c8939109a92b35582d5e5c
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SOX5 CD22 NEB CCDC144A	1.85e-04	194	65	4	b8f05efb16fbed7317019efc3da7f97f81e90972
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	SOX6 THRB ABCA5 DNAJC12	1.85e-04	194	65	4	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	SOX6 THRB ABCA5 DNAJC12	1.85e-04	194	65	4	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SOX5 CD22 AHNAK DGKD	1.85e-04	194	65	4	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JCAD PHLDB1 PAPSS2 IL18R1	1.85e-04	194	65	4	40842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SOX6 SOX5 DNAJC12 IL18R1	1.88e-04	195	65	4	c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SOX5 CD22 AHNAK DGKD	1.88e-04	195	65	4	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SOX5 CD22 AHNAK DGKD	1.88e-04	195	65	4	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PCSK2 SV2B DNAJC12 TNR	1.96e-04	197	65	4	3a0e97bfebe82f9687d518baaad7f20d0ffea8a1
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	SOX6 AHNAK UTRN EIF3CL	2.00e-04	198	65	4	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TCERG1L SV2B DNAJC12 ESPL1	2.00e-04	198	65	4	d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JCAD ULBP2 TNR IL18R1	2.00e-04	198	65	4	40c2171e79f578c9116d872c189f953dc61d052d
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-NK_CD56bright\|Influenza_Severe / Disease, condition lineage and cell class	ABCA5 NUP43 METTL15 IL18R1	2.04e-04	199	65	4	784e7e7ede2baa28ede600834813e6de2240bfdf
Disease	level of UL16-binding protein 6 in blood serum	ULBP2 RAET1L	4.63e-06	2	64	2	OBA_2043185
Disease	hematocrit	SOX6 SOX5 JCAD ZYG11A DNAJC13 ACACA ACSBG1 EXD1 SPO11 DGKD	6.03e-05	1011	64	10	EFO_0004348
Disease	Anorectal Malformations	CDK8 SOX6 FANCB	9.78e-05	41	64	3	C3495676
Disease	AUTISM, SUSCEPTIBILITY TO, 15	CDK8 SIN3A	1.29e-04	8	64	2	C2677504
Disease	amino acid measurement	CDK8 TYK2 SOX6 EXD1 PRSS55 GAN MLYCD	6.55e-04	678	64	7	EFO_0005134
Disease	C-reactive protein measurement	SOX6 SOX5 THRB AHNAK PRSS55 IL18R1 ATP8B2 MLYCD EIF3CL	1.13e-03	1206	64	9	EFO_0004458
Disease	lymphocyte count	TYK2 JCAD GTF2IRD2B THRB ACACA ACSBG1 AHNAK GTF2IRD2 DGKD ZNF295-AS1	1.15e-03	1464	64	10	EFO_0004587
Disease	multisite chronic pain	SOX6 SOX5 UTRN	1.17e-03	95	64	3	EFO_0010100
Disease	free androgen index	TYK2 SOX5 THRB SIN3A MLYCD	1.32e-03	374	64	5	EFO_0007005
Disease	alkaline phosphatase measurement	SOX6 PHLDB1 DNAJC13 AHNAK PRSS55 DNAJC12 UTRN MLYCD	1.53e-03	1015	64	8	EFO_0004533
Disease	R-6-hydroxywarfarin to R-warfarin ratio measurement	TCERG1L ACSBG1 GAN	1.60e-03	106	64	3	EFO_0803333
Disease	testosterone measurement	TYK2 SOX6 SOX5 DIP2B THRB SIN3A METTL15 UTRN MLYCD	1.65e-03	1275	64	9	EFO_0004908
Disease	peptide measurement	ABL2 THRB ACSBG1	1.73e-03	109	64	3	EFO_0010520
Disease	Severe Congenital Microcephaly	SIN3A TBCD	2.07e-03	31	64	2	C3853041

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGMDPKAKQHMWRAI	ABCA5	1461	Q8WWZ7
KEMQRWIMEKTAEHF	SDF4	121	Q9BRK5
PIHDKWEMERTDITM	ABL2	276	P42684
WEMERTDITMKHKLG	ABL2	281	P42684
MHWVVRGKKDLMLEE	DNAJC12	101	Q9UKB3
EIGMVAWKMTFKSPE	ACACA	1656	Q13085
VEVHDPDWHLKMPKM	AHNAK	1701	Q09666
RPVVWHGMAMVKALS	DNHD1	3851	Q96M86
MTVPKEMPEKWARAQ	ATP8B2	1	P98198
TMPVSLLKAHEAEMW	NUP43	251	Q8NFH3
HKPIWMHAEEREEMS	KLC4	421	Q9NSK0
TKHPHIKMVMESGDW	PAPSS2	351	O95340
EMRIMTPEGKWHASK	IL18R1	266	Q13478
EHVMKKPVWEEELRM	JCAD	161	Q9P266
HAERTWMEKMKVEDL	EXD1	31	Q8NHP7
EAVHPVKNWMDMKRR	MLYCD	216	O95822
KTVMEGWVKVMVPEA	HTD2	151	P86397
LKDLEMSKVVHMDRW	DGKA	486	P23743
KVALVKCRDLHWAMM	DIP2B	606	Q9P265
VSMRRAPLMWELIHK	METTL15	366	A6NJ78
SMKVWLLEHMKCEII	FANCB	671	Q8NB91
EHVVAASKAMKMGDW	EIF3CL	736	B5ME19
HMAEPVTFWVRVKMD	ESPL1	541	Q14674
PRAEMRPVKHKWTMI	IGSF10	461	Q6WRI0
MWMTPKRSKMEVDEA	EPM2AIP1	1	Q7L775
KVHMKDVMSALWVSG	GAN	211	Q9H2C0
MDARRKHWKENMFTP	CCDC160	1	A6NGH7
SHMGVPRVWEKIMER	ACSBG1	371	Q96GR2
IQAMKPMTKEEWDAR	ARL6IP4	166	Q66PJ3
KEKVDLVLMHWRDRM	DNAJC13	716	O75165
EHPEKCRSRTKNMMW	DGKD	786	Q16760
EWVRLHDKMKVDMSG	CCDC144A	946	A2RUR9
KMDHVMDVVVKSVNW	GTF2IRD2	666	Q86UP8
KMDHVMDVVVKSVNW	GTF2IRD2B	666	Q6EKJ0
DWEDIKKMPEHSTLM	CDK8	266	P49336
MESKTEKWMERIHLN	CD22	121	P20273
MKLWMESHLIVPETR	OR13A1	1	Q8NGR1
ILHWQVKDVMKDVMS	UTRN	131	P46939
EMGKHDEAWMILKQV	SV2B	306	Q7L1I2
HVPREMAAETSKWLM	SIN3A	1221	Q96ST3
KAHSDTWMVVLDPMK	SIAE	76	Q9HAT2
IKRPMNAFMVWAKDE	SOX6	621	P35712
PRKIIRMWAEKEMHN	RIOK3	321	O14730
TMHLSVWEKPMDLKD	TCERG1L	361	Q5VWI1
KEPWNMKRHEMVDEP	ZNF431	91	Q8TF32
HIWKKIMHTDAMIID	RBP3	1066	P10745
QPFWRKEMEIMADSK	SPO11	351	Q9Y5K1
KFMEDMMPKVHWLRT	RPEL1	151	Q2QD12
HFWPKLLMKVTDLRM	THRB	416	P10828
WKGHEFSIPFVEMKM	TNR	1326	Q92752
RMWTTVHPGARKMKE	RAET1G	156	Q6H3X3
HSAVWVPMMKEKASH	SERPINA13P	216	Q6UXR4
RMWTTVHPGARKMKE	RAET1L	156	Q5VY80
RFNHPAEAKWMKSMI	PHLDB1	131	Q86UU1
KAPMVIMDWEECSKM	PRSS55	211	Q6UWB4
EAWSMKRHEIMVAKP	ZNF85	61	Q03923
IKRPMNAFMVWAKDE	SOX5	556	P35711
QPMIDHLVTMKISHW	TBCD	561	Q9BTW9
MKDKMWCEDTAQPHR	ZNF295-AS1	1	Q8N0V1
RMWTTVHPGARKMKE	ULBP2	156	Q9BZM5
KFMEDMMPKVHWLRT	RPE	151	Q96AT9
VMRWLCKHENPKMQT	ZYG11A	471	Q6WRX3
RERGHVPMAWKMVVA	TYK2	701	P29597
PWHMKKAFKVMNELR	KLHL2	36	O95198
IRDDPKMMWSMHVAK	NEB	2811	P20929
KDDPKMMWSIHVAKI	NEB	3541	P20929
AMVKMAKDWKTVPER	PCSK2	451	P16519