Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	TCF4 TCF12 NR4A2 CREB3L1 HOXB1 KMT2D VENTX BRCA1 PAX8 TP63 PITX2 TBX20 NOTCH2 SMAD1 PROP1	2.09e-07	566	103	15	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	TCF4 TCF12 NR4A2 CREB3L1 HOXB1 KMT2D VENTX PAX8 TP63 PITX2 TBX20 NOTCH2 SMAD1 PROP1	1.10e-06	560	103	14	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	TCF4 TBX4 IRX5 TCF12 NR4A2 FOXI3 CREB3L1 NKX1-2 HOXB1 KMT2D VENTX PAX8 NFIL3 TP63 PITX2 ZFHX3 TBX20 MYRF NOTCH2 SMAD1 PROP1 SMAD9	2.45e-06	1412	103	22	GO:0000981
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	TCF4 TBX4 IRX5 TCF12 NR4A2 FOXI3 CREB3L1 NKX1-2 HOXB1 VENTX PAX8 NFIL3 TP63 PITX2 ZFHX3 TBX20 NOTCH2 SMAD1 PROP1 SMAD9	6.61e-06	1271	103	20	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TCF4 TBX4 IRX5 TCF12 NR4A2 FOXI3 CREB3L1 NKX1-2 HOXB1 VENTX PAX8 NFIL3 TP63 PITX2 ZFHX3 TBX20 SMAD1 PROP1 SMAD9	1.77e-05	1244	103	19	GO:0000978
GeneOntologyMolecularFunction	damaged DNA binding	KDM4E BRCA1 TP63 POLI REV1	7.40e-05	84	103	5	GO:0003684
GeneOntologyMolecularFunction	SMAD binding	TCF12 RANBP3 CREB3L1 SMAD1 SMAD9	8.28e-05	86	103	5	GO:0046332
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	TCF4 TBX4 IRX5 TCF12 NR4A2 FOXI3 CREB3L1 NKX1-2 HOXB1 VENTX PAX8 NFIL3 TP63 PITX2 ZFHX3 TBX20 SMAD1 PROP1 SMAD9	1.52e-04	1459	103	19	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	TCF4 IRX5 TCF12 NR4A2 SIK1 PITX2 TACC1 DOT1L TBX20 SPEN NOTCH2	2.07e-04	582	103	11	GO:0140297
GeneOntologyMolecularFunction	beta-N-acetylhexosaminidase activity	HEXB CHIA	3.90e-04	6	103	2	GO:0004563
GeneOntologyMolecularFunction	transcription factor binding	TCF4 IRX5 TCF12 PCLO NR4A2 SIK1 PITX2 TACC1 DOT1L TBX20 SPEN NOTCH2	5.00e-04	753	103	12	GO:0008134
GeneOntologyMolecularFunction	alpha-actinin binding	MAGI1 LDB3 ALMS1	5.39e-04	31	103	3	GO:0051393
GeneOntologyMolecularFunction	DEAD/H-box RNA helicase binding	SMAD1 ZC3HAV1	9.26e-04	9	103	2	GO:0017151
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase activator activity	IRS1 AGAP2	9.26e-04	9	103	2	GO:0141038
GeneOntologyMolecularFunction	actinin binding	MAGI1 LDB3 ALMS1	1.42e-03	43	103	3	GO:0042805
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2D SETD5 DOT1L	1.51e-03	44	103	3	GO:0140938
GeneOntologyMolecularFunction	cAMP response element binding	TCF12 CREB3L1	1.68e-03	12	103	2	GO:0035497
GeneOntologyMolecularFunction	ionotropic glutamate receptor binding	NETO2 SHISA6 AGAP2	2.45e-03	52	103	3	GO:0035255
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	HEXB RAF1 TCF4 TCF12 TCF20 DVL2 NR4A2 CREB3L1 HOXB1 KMT2D VENTX BRCA1 PAX8 TP63 PITX2 CAPRIN2 ZFHX3 DOT1L TBX20 NOTCH2 SMAD1 PROP1 AGAP2 SMAD9	5.26e-08	1390	102	24	GO:0045944
GeneOntologyBiologicalProcess	positive regulation of cell differentiation	TCF4 RELN TCF12 KALRN L1CAM PAX8 TP63 CAPRIN2 ZFHX3 TBX20 SPEN KDF1 MYRF CAPRIN1 IL4R NOTCH2 SMAD1 SMAD9	1.12e-05	1141	102	18	GO:0045597
GeneOntologyBiologicalProcess	pattern specification process	RELN ANKS6 DVL2 HOXB1 PAX8 TP63 PITX2 CAPRIN2 TBX20 NOTCH2 SMAD1 PROP1	1.12e-05	526	102	12	GO:0007389
GeneOntologyBiologicalProcess	positive regulation of dendritic spine morphogenesis	RELN KALRN CAPRIN2 CAPRIN1	2.33e-05	34	102	4	GO:0061003
GeneOntologyBiologicalProcess	pulmonary vein morphogenesis	PITX2 TBX20	2.42e-05	2	102	2	GO:0060577
GeneOntologyBiologicalProcess	regionalization	RELN ANKS6 DVL2 HOXB1 PAX8 TP63 PITX2 CAPRIN2 TBX20 NOTCH2 PROP1	2.47e-05	478	102	11	GO:0003002
GeneOntologyBiologicalProcess	embryonic morphogenesis	EYA4 TBX4 IRX5 DVL2 AHDC1 HOXB1 PAX8 TP63 PITX2 TBX20 KDF1 NOTCH2 SMAD1	4.98e-05	713	102	13	GO:0048598
GeneOntologyBiologicalProcess	regulation of epidermal cell division	TP63 KDF1	7.24e-05	3	102	2	GO:0010482
GeneOntologyBiologicalProcess	epidermal cell division	TP63 KDF1	7.24e-05	3	102	2	GO:0010481
GeneOntologyBiologicalProcess	gland development	RAF1 KALRN CEACAM8 IRS1 FOXI3 PAX8 TP63 PITX2 NOTCH2 PROP1 AGAP2	9.93e-05	558	102	11	GO:0048732
GeneOntologyBiologicalProcess	regulation of cell morphogenesis	HEXB RELN KALRN DVL2 CPNE5 MYH14 CAPRIN2 CAPRIN1	1.28e-04	302	102	8	GO:0022604
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	HMBOX1 TCF4 NR4A2 SIK1 ZC3H6 CREB3L1 HMG20A BRCA1 SETD5 NFIL3 SCML1 TP63 PITX2 ZFHX3 TBX20 SPEN NOTCH2 PROP1	1.60e-04	1399	102	18	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	HMBOX1 TCF4 NR4A2 SIK1 ZC3H6 CREB3L1 HMG20A BRCA1 SETD5 NFIL3 SCML1 TP63 PITX2 ZFHX3 TBX20 SPEN NOTCH2 PROP1	1.81e-04	1413	102	18	GO:1902679
GeneOntologyBiologicalProcess	regulation of nervous system process	DLGAP2 RELN PCLO NETO2 MYRF SHISA6	2.35e-04	175	102	6	GO:0031644
GeneOntologyBiologicalProcess	regulation of dendritic spine morphogenesis	RELN KALRN CAPRIN2 CAPRIN1	2.85e-04	64	102	4	GO:0061001
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	MYBPH TCF4 RELN TBX4 DVL2 FHOD3 AHDC1 CREB3L1 HOXB1 LDB3 BRCA1 PAX8 TP63 PITX2 TBX20 IL4R NOTCH2 SMAD1	3.26e-04	1483	102	18	GO:0048646
GeneOntologyBiologicalProcess	positive regulation of dendrite morphogenesis	RELN KALRN CAPRIN2 CAPRIN1	3.40e-04	67	102	4	GO:0050775
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	EYA4 IRX5 DVL2 HOXB1 PAX8 PITX2 TBX20 NOTCH2	3.55e-04	351	102	8	GO:0048562
GeneOntologyBiologicalProcess	somatotropin secreting cell differentiation	PITX2 PROP1	3.59e-04	6	102	2	GO:0060126
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	RELN KALRN L1CAM CAPRIN2 SPEN MYRF CAPRIN1 NOTCH2	3.76e-04	354	102	8	GO:0050769
GeneOntologyBiologicalProcess	positive regulation of cell morphogenesis	RELN KALRN CAPRIN2 CAPRIN1	3.81e-04	69	102	4	GO:0010770
GeneOntologyBiologicalProcess	positive regulation of dendritic spine development	RELN KALRN CAPRIN2 CAPRIN1	4.02e-04	70	102	4	GO:0060999
GeneOntologyCellularComponent	chromatin	HMBOX1 TCF4 TBX4 IRX5 TCF12 NR4A2 KDM4E ZC3H6 CREB3L1 NKX1-2 HOXB1 VENTX SETD5 PAX8 NFIL3 TP63 PITX2 ZFHX3 TBX20 SMAD1 PROP1 SMAD9	2.97e-06	1480	104	22	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	TCF4 TCF12 NR4A2 PAX8 NFIL3 PITX2 ZFHX3 SPEN SMAD1 PROP1 SMAD9	1.87e-04	596	104	11	GO:0005667
HumanPheno	Abnormal palate morphology	THSD4 RAF1 TCF4 TBX4 IRX5 DONSON PCLO L1CAM NR4A2 SIK1 SEC31A FOXI3 KIAA0753 HOXB1 KMT2D BRCA1 PROKR2 SETD5 TP63 KBTBD13 SPEN KDF1 PIGO NOTCH2 PROP1	1.01e-05	1202	47	25	HP:0000174
HumanPheno	Aplasia/Hypoplasia involving bones of the skull	RAF1 RELN TBX4 IRX5 DONSON SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D BRCA1 SETD5 TP63 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	1.93e-05	915	47	21	HP:0009116
HumanPheno	Abnormal nasal bridge morphology	RAF1 TCF4 RELN TBX4 IRX5 TCF20 PCLO SIK1 AHDC1 KIAA0753 HOXB1 KMT2D BRCA1 PROKR2 SETD5 TP63 PITX2 SPEN MYRF PIGO NOTCH2 PROP1	3.42e-05	1029	47	22	HP:0000422
HumanPheno	Abnormality of globe location or size	THSD4 RAF1 TCF4 RELN TBX4 IRX5 TCF12 DONSON TCF20 PCLO NR4A2 AHDC1 KIAA0753 KMT2D ALMS1 BRCA1 PROKR2 SETD5 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	6.94e-05	1246	47	24	HP:0000489
HumanPheno	Aplasia/hypoplasia involving the skeleton	RAF1 TCF4 RELN TBX4 IRX5 DONSON SIK1 SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D ALMS1 BRCA1 SETD5 TP63 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2 PROP1	7.75e-05	1343	47	25	HP:0009115
HumanPheno	Micrognathia	RAF1 RELN TBX4 IRX5 DONSON SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D BRCA1 SETD5 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	7.93e-05	843	47	19	HP:0000347
HumanPheno	Aplasia/Hypoplasia of the mandible	RAF1 RELN TBX4 IRX5 DONSON SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D BRCA1 SETD5 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	8.20e-05	845	47	19	HP:0009118
HumanPheno	Left unicoronal synostosis	TCF12 PIGO	8.33e-05	2	47	2	HP:0011316
HumanPheno	Aplasia/hypoplasia affecting bones of the axial skeleton	RAF1 RELN TBX4 IRX5 DONSON SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D BRCA1 SETD5 TP63 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	8.75e-05	1008	47	21	HP:0009122
HumanPheno	Abnormality of globe location	THSD4 RAF1 TCF4 RELN TBX4 IRX5 TCF12 TCF20 PCLO NR4A2 AHDC1 KIAA0753 KMT2D ALMS1 BRCA1 PROKR2 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	1.36e-04	1122	47	22	HP:0100886
HumanPheno	Finger clinodactyly	RAF1 TCF4 TBX4 IRX5 DONSON TCF20 L1CAM KIAA0753 KMT2D BRCA1 TP63 SPEN CAPRIN1	1.50e-04	452	47	13	HP:0040019
HumanPheno	Abnormal facial shape	HEXB RAF1 TCF4 RELN TBX4 TCF20 L1CAM NR4A2 SEC31A AHDC1 KIAA0753 KMT2D ALMS1 BRCA1 PAX8 TP63 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2 PROP1	1.62e-04	1221	47	23	HP:0001999
HumanPheno	Abnormal toe morphology	THSD4 TCF4 TBX4 IRX5 TCF12 TCF20 L1CAM NR4A2 SIK1 KIAA0753 KMT2D ALMS1 BRCA1 SETD5 TP63 SPEN MYRF PIGO NOTCH2	1.76e-04	893	47	19	HP:0001780
HumanPheno	Severe sensorineural hearing impairment	RAF1 KMT2D ALMS1	1.97e-04	13	47	3	HP:0008625
HumanPheno	Downturned corners of mouth	TCF20 PCLO KIAA0753 HOXB1 KMT2D SETD5 PIGO NOTCH2	2.17e-04	182	47	8	HP:0002714
HumanPheno	Hypertelorism	THSD4 RAF1 RELN TBX4 IRX5 TCF12 NR4A2 AHDC1 KIAA0753 KMT2D BRCA1 PROKR2 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	2.25e-04	830	47	18	HP:0000316
HumanPheno	Anal stenosis	KMT2D TP63 PITX2 PIGO	2.41e-04	34	47	4	HP:0002025
HumanPheno	Depressed nasal bridge	RAF1 TBX4 TCF20 PCLO SIK1 AHDC1 KIAA0753 HOXB1 KMT2D PROKR2 SETD5 TP63 PITX2 SPEN PROP1	2.47e-04	612	47	15	HP:0005280
HumanPheno	Flattened nasal bridge	RAF1 TBX4 TCF20 PCLO SIK1 AHDC1 KIAA0753 HOXB1 KMT2D PROKR2 SETD5 TP63 PITX2 SPEN PROP1	2.47e-04	612	47	15	HP:0000425
HumanPheno	Severe hearing impairment	RAF1 KMT2D ALMS1	2.50e-04	14	47	3	HP:0012714
HumanPheno	Abnormality of the jaws	THSD4 RAF1 RELN TBX4 IRX5 DONSON SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D BRCA1 SETD5 TP63 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	2.78e-04	1175	47	22	HP:0000209
HumanPheno	Abnormal jaw morphology	THSD4 RAF1 RELN TBX4 IRX5 DONSON SEC31A FOXI3 AHDC1 CREB3L1 KIAA0753 HOXB1 KMT2D BRCA1 SETD5 TP63 PITX2 KBTBD13 SPEN CAPRIN1 PIGO NOTCH2	2.82e-04	1176	47	22	HP:0030791
HumanPheno	Abnormal penis morphology	HEXB RAF1 TCF4 TCF12 SIK1 KIAA0753 KMT2D ALMS1 BRCA1 PROKR2 SETD5 TP63 PITX2 SPEN MYRF NOTCH2	3.92e-04	712	47	16	HP:0000036
HumanPheno	Abnormal finger morphology	THSD4 RAF1 TCF4 RELN TBX4 IRX5 DONSON TCF20 L1CAM NR4A2 SIK1 KIAA0753 KMT2D ALMS1 BRCA1 PROKR2 SETD5 TP63 SPEN KDF1 CAPRIN1 PIGO NOTCH2 PROP1	4.09e-04	1385	47	24	HP:0001167
HumanPheno	Cleft palate	TBX4 DONSON NR4A2 SIK1 FOXI3 KIAA0753 KMT2D BRCA1 PROKR2 SETD5 TP63 KDF1 PIGO NOTCH2 PROP1	4.27e-04	643	47	15	HP:0000175
HumanPheno	Clinodactyly	RAF1 TCF4 TBX4 IRX5 DONSON TCF20 L1CAM KIAA0753 KMT2D BRCA1 TP63 SPEN CAPRIN1 PIGO	4.49e-04	574	47	14	HP:0030084
HumanPheno	Abnormal hard palate morphology	TBX4 DONSON NR4A2 SIK1 FOXI3 KIAA0753 KMT2D BRCA1 PROKR2 SETD5 TP63 KDF1 PIGO NOTCH2 PROP1	4.57e-04	647	47	15	HP:0100737
HumanPheno	Wide nasal bridge	RAF1 TCF4 RELN IRX5 KIAA0753 KMT2D SETD5 TP63 PITX2 SPEN MYRF PIGO NOTCH2	4.81e-04	508	47	13	HP:0000431
HumanPheno	Hypospadias	RAF1 TCF12 KIAA0753 KMT2D BRCA1 SETD5 TP63 PITX2 SPEN MYRF NOTCH2	4.83e-04	377	47	11	HP:0000047
HumanPheno	Scimitar anomaly	KMT2D MYRF	4.94e-04	4	47	2	HP:0011626
MousePheno	postnatal lethality	UBE2J1 TCF4 RELN EYA4 TCF12 TCF20 L1CAM IRS1 FIGN FOXI3 HOXB1 AKTIP LDB3 PROKR2 PAX8 PITX2 ZFHX3 SMAD1 PROP1	2.50e-05	1084	86	19	MP:0002082
MousePheno	abnormal uterine cervix morphology	BRCA1 PAX8 TP63	3.58e-05	11	86	3	MP:0001135
MousePheno	abnormal uterine cervix epithelium morphology	BRCA1 TP63	3.74e-05	2	86	2	MP:0001137
MousePheno	abnormal thyrotroph morphology	PAX8 PITX2 PROP1	7.79e-05	14	86	3	MP:0008326
MousePheno	neonatal lethality	RAF1 TCF4 EYA4 NR4A2 FOXI3 HOXB1 LDB3 PROKR2 TP63 PITX2 MAST1 KDF1 CAPRIN1 NOTCH2 PROP1	9.64e-05	799	86	15	MP:0002058
MousePheno	perinatal lethality	RAF1 TCF4 ANKS6 EYA4 DVL2 NR4A2 FOXI3 AHDC1 HOXB1 LDB3 PROKR2 TP63 PITX2 MAST1 KDF1 CAPRIN1 NOTCH2 PROP1	1.46e-04	1130	86	18	MP:0002081
MousePheno	abnormal coronary sinus morphology	ANKS6 SETD5 PITX2	1.72e-04	18	86	3	MP:0010436
MousePheno	abnormal nervous system development	RAF1 TCF4 RELN TCF12 TCF20 KALRN ARHGEF5 L1CAM DVL2 NR4A2 FHOD3 FIGN FOXI3 HOXB1 BRCA1 PROKR2 PITX2 TBX20 SMAD1	1.84e-04	1257	86	19	MP:0003861
MousePheno	lethality during fetal growth through weaning, complete penetrance	RAF1 TCF4 ANKS6 EYA4 TCF12 L1CAM NR4A2 FOXI3 AHDC1 LDB3 SETD5 PAX8 TP63 PITX2 MAST1 SPEN KDF1 CAPRIN1 NOTCH2	2.08e-04	1269	86	19	MP:0011111
MousePheno	abnormal prenatal growth/weight/body size	RAF1 ANKS6 EYA4 TBX4 TCF20 FHOD3 IRS1 AHDC1 HMG20A KIAA0753 BRCA1 SETD5 TP63 PITX2 ZFR DOT1L TBX20 MYRF CAPRIN1 NOTCH2 SMAD1	2.15e-04	1493	86	21	MP:0004196
MousePheno	absent umbilical cord	TBX4 SMAD1	2.23e-04	4	86	2	MP:0012134
MousePheno	abnormal azygos vein morphology	ANKS6 SETD5 PITX2	2.38e-04	20	86	3	MP:0011569
MousePheno	abnormal ventral body wall morphology	TP63 PITX2 SMAD1	2.76e-04	21	86	3	MP:0003384
MousePheno	decreased somatotroph cell number	PAX8 PITX2 PROP1	2.76e-04	21	86	3	MP:0008329
Domain	Homeodomain-like	HMBOX1 TCF4 IRX5 TCF12 NKX1-2 HOXB1 VENTX PAX8 PITX2 ZFHX3 PROP1	1.81e-06	332	101	11	IPR009057
Domain	Caprin	CAPRIN2 CAPRIN1	2.90e-05	2	101	2	IPR028816
Domain	Caprin-1_C	CAPRIN2 CAPRIN1	2.90e-05	2	101	2	PF12287
Domain	Caprin-1_C	CAPRIN2 CAPRIN1	2.90e-05	2	101	2	IPR022070
Domain	Homeobox	HMBOX1 IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	4.00e-05	234	101	8	PF00046
Domain	HOMEOBOX_1	HMBOX1 IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	4.25e-05	236	101	8	PS00027
Domain	HOX	HMBOX1 IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	4.38e-05	237	101	8	SM00389
Domain	HOMEOBOX_2	HMBOX1 IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	4.64e-05	239	101	8	PS50071
Domain	Homeobox_dom	HMBOX1 IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	4.64e-05	239	101	8	IPR001356
Domain	Homeobox_CS	IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	6.78e-05	186	101	7	IPR017970
Domain	DUF4211	PRR12 QSER1	8.66e-05	3	101	2	PF13926
Domain	DUF4211	PRR12 QSER1	8.66e-05	3	101	2	IPR025451
Domain	-	HMBOX1 IRX5 NKX1-2 HOXB1 VENTX PITX2 ZFHX3 PROP1	1.51e-04	283	101	8	1.10.10.60
Domain	IMS	POLI REV1	1.73e-04	4	101	2	PF00817
Domain	IMS_C	POLI REV1	1.73e-04	4	101	2	PF11799
Domain	UMUC	POLI REV1	1.73e-04	4	101	2	PS50173
Domain	-	POLI REV1	1.73e-04	4	101	2	3.30.1490.100
Domain	DNA_pol_Y-fam_little_finger	POLI REV1	1.73e-04	4	101	2	IPR017961
Domain	p53-like_TF_DNA-bd	TBX4 TP63 TBX20 MYRF	1.92e-04	53	101	4	IPR008967
Domain	AT_hook	AHDC1 PRR12 DOT1L	4.09e-04	27	101	3	SM00384
Domain	AT_hook_DNA-bd_motif	AHDC1 PRR12 DOT1L	4.09e-04	27	101	3	IPR017956
Domain	TF_Brachyury	TBX4 TBX20	4.28e-04	6	101	2	IPR002070
Domain	UmuC	POLI REV1	4.28e-04	6	101	2	IPR001126
Domain	Dwarfin	SMAD1 SMAD9	7.94e-04	8	101	2	IPR013790
Domain	DWB	SMAD1 SMAD9	7.94e-04	8	101	2	SM00524
Domain	MH2	SMAD1 SMAD9	7.94e-04	8	101	2	PS51076
Domain	MH1	SMAD1 SMAD9	7.94e-04	8	101	2	PS51075
Domain	-	SMAD1 SMAD9	7.94e-04	8	101	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD9	7.94e-04	8	101	2	IPR013019
Domain	MH2	SMAD1 SMAD9	7.94e-04	8	101	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD9	7.94e-04	8	101	2	IPR001132
Domain	PDZ	MAGI1 PCLO DVL2 LDB3 MAST1	1.37e-03	151	101	5	PS50106
Domain	PDZ	MAGI1 PCLO DVL2 LDB3 MAST1	1.41e-03	152	101	5	IPR001478
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD9	1.84e-03	12	101	2	IPR003619
Domain	DWA	SMAD1 SMAD9	1.84e-03	12	101	2	SM00523
Domain	MH1	SMAD1 SMAD9	1.84e-03	12	101	2	PF03165
Domain	Disintegrin_CS	ADAM21 ADAM20	3.31e-03	16	101	2	IPR018358
Domain	SMAD_dom-like	SMAD1 SMAD9	3.31e-03	16	101	2	IPR017855
Domain	AT_hook	PRR12 DOT1L	3.31e-03	16	101	2	PF02178
Domain	-	SMAD1 SMAD9	3.31e-03	16	101	2	2.60.200.10
Domain	TF_T-box	TBX4 TBX20	3.73e-03	17	101	2	IPR001699
Domain	TBOX	TBX4 TBX20	3.73e-03	17	101	2	SM00425
Domain	TF_T-box_CS	TBX4 TBX20	3.73e-03	17	101	2	IPR018186
Domain	-	TBX4 TBX20	3.73e-03	17	101	2	2.60.40.820
Domain	TBOX_3	TBX4 TBX20	3.73e-03	17	101	2	PS50252
Domain	T-box	TBX4 TBX20	3.73e-03	17	101	2	PF00907
Domain	TBOX_1	TBX4 TBX20	3.73e-03	17	101	2	PS01283
Domain	TBOX_2	TBX4 TBX20	3.73e-03	17	101	2	PS01264
Domain	ADAM_CR	ADAM21 ADAM20	4.19e-03	18	101	2	PF08516
Domain	BRCT	BRCA1 REV1	4.66e-03	19	101	2	PF00533
Domain	-	ADAM21 ADAM20	5.16e-03	20	101	2	4.10.70.10
Domain	Disintegrin	ADAM21 ADAM20	5.69e-03	21	101	2	PF00200
Domain	DISIN	ADAM21 ADAM20	5.69e-03	21	101	2	SM00050
Domain	EPHD	TCF20 KMT2D	6.23e-03	22	101	2	PS51805
Domain	BRCT	BRCA1 REV1	6.23e-03	22	101	2	SM00292
Pubmed	A census of human transcription factors: function, expression and evolution.	HMBOX1 TCF4 TBX4 IRX5 TCF12 NR4A2 FOXI3 CREB3L1 HOXB1 KMT2D VENTX PAX8 NFIL3 TP63 PITX2 ZFHX3 TBX20 MYRF SMAD1 PROP1 SMAD9	2.98e-13	908	104	21	19274049
Pubmed	Human transcription factor protein interaction networks.	HMBOX1 TCF4 EYA4 TCF12 TCF20 PROSER1 FIGN HMG20A PRR12 KMT2D ALMS1 BRCA1 PAX8 MYH14 ZFR ZFHX3 QSER1 DOT1L LSM14B SPEN CAPRIN1 ZC3HAV1	2.07e-10	1429	104	22	35140242
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	HMBOX1 IRX5 NR4A2 CREB3L1 HMG20A NKX1-2 HOXB1 LDB3 PITX2 ZFHX3	7.21e-09	263	104	10	20932939
Pubmed	Interaction network of human early embryonic transcription factors.	EYA4 TCF20 PROSER1 AHDC1 PRR12 KMT2D ALMS1 PITX2 ZFHX3 QSER1 SPEN	9.15e-09	351	104	11	38297188
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	TCF4 TBX4 TCF12 TCF20 CREB3L1 HMG20A HOXB1 VENTX BRCA1 PAX8 TP63 PITX2 TBX20 SPEN SMAD1	5.58e-08	877	104	15	20211142
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	HMBOX1 TCF4 IRX5 TCF12 NR4A2 CREB3L1 HOXB1 VENTX PAX8 PITX2 TBX20 PROP1	8.91e-08	544	104	12	28473536
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HMBOX1 TCF4 TBX4 TCF12 TCF20 ZC3H6 HMG20A NFIL3 PITX2 ZFR ZFHX3 TBX20 SMAD1 ZC3HAV1	1.38e-07	808	104	14	20412781
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HMBOX1 TCF4 TBX4 TCF12 TCF20 NR4A2 NKX1-2 LDB3 BRCA1 PITX2 ZFR ZFHX3 SMAD9	2.10e-07	709	104	13	22988430
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TCF4 EYA4 TCF12 DVL2 BEND4 SNX33 KMT2D NFIL3 PITX2 ZFR QSER1 SPEN NOTCH2 SMAD9	2.80e-07	857	104	14	25609649
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	HMBOX1 RAF1 TCF4 EYA4 TCF12 NR4A2 CPA2 CREB3L1 HMG20A KIAA0753 LDB3 TP63 TACC1	3.52e-07	742	104	13	26871637
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TCF4 EYA4 PROSER1 PRR12 ALMS1 PITX2 KBTBD13	3.95e-07	152	104	7	38360978
Pubmed	BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin.	TCF4 TP63 SMAD1 SMAD9	5.29e-07	22	104	4	25329657
Pubmed	TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.	PITX2 NOTCH2 SMAD1 PROP1	5.29e-07	22	104	4	17919533
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	HMBOX1 TCF4 TCF12 RANBP3 L1CAM SEC31A AHDC1 ZFHX3 TACC1 NOTCH2 REV1	6.45e-07	536	104	11	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	HMBOX1 TCF4 TCF12 RANBP3 L1CAM SEC31A AHDC1 ZFHX3 TACC1 NOTCH2 REV1	6.69e-07	538	104	11	10512203
Pubmed	The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling.	PITX2 TBX20 SMAD1 SMAD9	9.09e-07	25	104	4	33846290
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	TCF4 TCF12 TCF20 AHDC1 PRR12 SPEN	9.75e-07	109	104	6	33554859
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKS6 KALRN L1CAM IRS1 AHDC1 NBPF1 PRR12 KMT2D SLC12A4 SETD5 DOT1L SPEN MYRF IL4R NOTCH2	1.05e-06	1105	104	15	35748872
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	TCF12 KIAA0753 PRR12 KMT2D ALMS1 SPEN NOTCH2	1.43e-06	184	104	7	32908313
Pubmed	Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.	TBX4 SMAD1 SMAD9	1.44e-06	8	104	3	29126155
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAF1 MAGI1 TCF20 ARHGEF5 RANBP3 SIK1 IRS1 KIAA0753 ALMS1 SYNJ2 RBM7 NOTCH2 ZC3HAV1	1.84e-06	861	104	13	36931259
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	TCF4 TCF12 HMG20A SPEN	1.95e-06	30	104	4	26593974
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ANKS6 TCF12 MUC16 SEC31A DMXL1 BRCA1 ZFR ZFHX3 TACC1 SPEN NOTCH2 ZC3HAV1	3.76e-06	777	104	12	35844135
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	TCF20 PRR12 KMT2D TP63 SPEN	5.24e-06	83	104	5	28794006
Pubmed	Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation.	CREB3L1 SMAD1 SMAD9	5.60e-06	12	104	3	22828627
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	AHDC1 BRCA1 DOT1L	5.60e-06	12	104	3	28700933
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	DVL2 PITX2 NOTCH2	5.60e-06	12	104	3	12421720
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	RAF1 DLGAP2 ARHGEF5 RANBP3 RHBDD2 TP63 ZFR SPEN SMAD1	6.05e-06	430	104	9	35044719
Pubmed	BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.	PITX2 SMAD1 SMAD9	7.27e-06	13	104	3	18550712
Pubmed	Regional regulation of Filiform tongue papillae development by Ikkα/Irf6.	TP63 SMAD1 SMAD9	7.27e-06	13	104	3	27302476
Pubmed	KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis.	KMT2D TP63	8.86e-06	2	104	2	29440247
Pubmed	Expression of basic-helix-loop-helix transcription factor ME2 during brain development and in the regions of neuronal plasticity in the adult brain.	TCF4 TCF12	8.86e-06	2	104	2	7984047
Pubmed	Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.	IRS1 IL4R	8.86e-06	2	104	2	8599766
Pubmed	The role of E-proteins in B- and T-lymphocyte development.	TCF4 TCF12	8.86e-06	2	104	2	9618760
Pubmed	Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation.	PITX2 ZFHX3	8.86e-06	2	104	2	26267381
Pubmed	Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.	CAPRIN2 CAPRIN1	8.86e-06	2	104	2	14764709
Pubmed	Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation.	PITX2 ZFHX3	8.86e-06	2	104	2	25391453
Pubmed	RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.	CAPRIN2 CAPRIN1	8.86e-06	2	104	2	20516077
Pubmed	ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.	BRCA1 TP63	8.86e-06	2	104	2	26704768
Pubmed	Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.	TCF4 DOT1L	8.86e-06	2	104	2	22566624
Pubmed	ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha.	ADAM21 ADAM20	8.86e-06	2	104	2	9469942
Pubmed	PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract.	PAX8 TP63	8.86e-06	2	104	2	20463571
Pubmed	The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification.	TCF4 TCF12	8.86e-06	2	104	2	30936870
Pubmed	Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.	TBX4 SMAD1 SMAD9	9.23e-06	14	104	3	23028455
Pubmed	Bmp in podocytes is essential for normal glomerular capillary formation.	NOTCH2 SMAD1 SMAD9	9.23e-06	14	104	3	18272846
Pubmed	Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.	NOTCH2 SMAD1 SMAD9	9.23e-06	14	104	3	22865640
Pubmed	Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation.	RELN L1CAM NR4A2	9.23e-06	14	104	3	31749685
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	HEXB UBE2J1 DVL2 RHBDD2 SEC31A RBM7 ZFR TACC1 LSM14B CAPRIN1 PIGO NOTCH2 ZC3HAV1	1.00e-05	1007	104	13	34597346
Pubmed	ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.	PITX2 SMAD1 SMAD9	1.15e-05	15	104	3	24912677
Pubmed	Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells.	NOTCH2 SMAD1 SMAD9	1.15e-05	15	104	3	20727876
Pubmed	Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice.	TP63 SMAD1 SMAD9	1.15e-05	15	104	3	26116174
Pubmed	WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.	HOXB1 SMAD1 SMAD9	1.15e-05	15	104	3	25031030
Pubmed	Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation.	L1CAM SMAD1 SMAD9	1.41e-05	16	104	3	29317485
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	RAF1 MAGI1 ARHGEF5 IRS1 SYNJ2	1.44e-05	102	104	5	15778465
Pubmed	Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium.	PITX2 SMAD1 SMAD9	1.71e-05	17	104	3	18667074
Pubmed	Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.	PITX2 SMAD1 SMAD9	1.71e-05	17	104	3	18832393
Pubmed	Arx homeobox gene is essential for development of mouse olfactory system.	RELN L1CAM NR4A2	1.71e-05	17	104	3	15677725
Pubmed	DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons.	TCF4 RELN PROKR2 DOT1L	1.83e-05	52	104	4	37566909
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYBPH TCF12 KALRN SEC31A AKTIP ALMS1 MYH14 NFIL3 NOTCH2	1.91e-05	497	104	9	23414517
Pubmed	p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.	TP63 SMAD1 SMAD9	2.05e-05	18	104	3	19717565
Pubmed	Tissue-specific roles of FGF signaling in external genitalia development.	TP63 SMAD1 SMAD9	2.05e-05	18	104	3	25820239
Pubmed	Threshold-specific requirements for Bmp4 in mandibular development.	PITX2 SMAD1 SMAD9	2.05e-05	18	104	3	15936012
Pubmed	Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation.	PITX2 SMAD1 SMAD9	2.05e-05	18	104	3	32105214
Pubmed	Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract.	PITX2 SMAD1 SMAD9	2.05e-05	18	104	3	17601530
Pubmed	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	TCF4 TBX4 DVL2 NR4A2 IRS1 NOTCH2 SMAD1 PROP1	2.06e-05	383	104	8	19453261
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	UBE2J1 ANKS6 RHBDD2 DMXL1 SLC12A4 NETO2 TACC1 NOTCH2 ZC3HAV1	2.13e-05	504	104	9	34432599
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	DLGAP2 AHDC1 HMG20A SYNJ2 TACC1	2.16e-05	111	104	5	22558309
Pubmed	Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.	TCF4 PITX2 SMAD1 SMAD9	2.29e-05	55	104	4	28807898
Pubmed	Isl1Cre reveals a common Bmp pathway in heart and limb development.	TBX4 TBX20 SMAD1	2.43e-05	19	104	3	16556916
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	UBE2J1 ANKS6 NBEAL1 DMXL1 CAPRIN1 NOTCH2 ZC3HAV1	2.49e-05	285	104	7	34369648
Pubmed	PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex.	PITX2 DOT1L	2.65e-05	3	104	2	24486544
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD9	2.65e-05	3	104	2	30953749
Pubmed	Notch signaling regulates follicular helper T cell differentiation.	IL4R NOTCH2	2.65e-05	3	104	2	23918982
Pubmed	Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations.	PITX2 ZFHX3	2.65e-05	3	104	2	23042660
Pubmed	Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.	KMT2D NOTCH2	2.65e-05	3	104	2	27566587
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD9	2.65e-05	3	104	2	21381028
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD9	2.65e-05	3	104	2	24023003
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD9	2.65e-05	3	104	2	31127639
Pubmed	ALF1, a basic helix-loop-helix transcription factor, maps to mouse chromosome 9.	TCF4 TCF12	2.65e-05	3	104	2	8833258
Pubmed	E2-2 regulates the expansion of pro-B cells and follicular versus marginal zone decisions.	TCF4 TCF12	2.65e-05	3	104	2	17082585
Pubmed	Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.	CHIA IL4R	2.65e-05	3	104	2	30500858
Pubmed	DNA polymerase ι is acetylated in response to SN2 alkylating agents.	POLI REV1	2.65e-05	3	104	2	30886224
Pubmed	A role for E2-2 at the DN3 stage of early thymopoiesis.	TCF4 TCF12	2.65e-05	3	104	2	18384878
Pubmed	A genetic and developmental biological approach for a family with complex congenital heart diseases-evidence of digenic inheritance.	PITX2 TBX20	2.65e-05	3	104	2	37180804
Pubmed	Ontogeny of the cell adhesion molecule L1 in the cerebellum of weaver and reeler mutant mice.	RELN L1CAM	2.65e-05	3	104	2	7969746
Pubmed	The helix-loop-helix gene E2A is required for B cell formation.	TCF4 TCF12	2.65e-05	3	104	2	8001124
Pubmed	Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.	TCF4 TCF12	2.65e-05	3	104	2	30593567
Pubmed	Immunohistochemistry for the novel markers glypican 3, PAX8, and p40 (ΔNp63) in squamous cell and urothelial carcinoma.	PAX8 TP63	2.65e-05	3	104	2	24225756
Pubmed	DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair.	BRCA1 DOT1L	2.65e-05	3	104	2	39172790
Pubmed	MADR1, a MAD-related protein that functions in BMP2 signaling pathways.	SMAD1 SMAD9	2.65e-05	3	104	2	8653785
Pubmed	Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.	TCF4 TCF12	2.65e-05	3	104	2	18854153
Pubmed	Prevalence and architecture of de novo mutations in developmental disorders.	TCF20 SPEN	2.65e-05	3	104	2	28135719
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD9	2.65e-05	3	104	2	27848974
Pubmed	The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection.	SPEN NOTCH2	2.65e-05	3	104	2	25381127
Pubmed	Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.	SMAD1 SMAD9	2.65e-05	3	104	2	22897816
Pubmed	MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus.	RAF1 IRS1	2.65e-05	3	104	2	35422233
Pubmed	BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers.	BRCA1 TP63	2.65e-05	3	104	2	23863842
Pubmed	The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities.	PITX2 PROP1	2.65e-05	3	104	2	9685346
Pubmed	Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning.	TCF4 TCF12	2.65e-05	3	104	2	1321336
Pubmed	A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.	IRS1 BRCA1	2.65e-05	3	104	2	22729394
Interaction	TLE3 interactions	TCF4 TCF12 TCF20 PROSER1 FIGN AHDC1 PRR12 KMT2D VENTX PAX8 ZFHX3 DOT1L TBX20 SPEN	6.55e-09	376	102	14	int:TLE3
Interaction	PAX9 interactions	TCF20 PROSER1 FIGN HMG20A PRR12 KMT2D ZFHX3 QSER1	3.18e-07	130	102	8	int:PAX9
Interaction	HNF1B interactions	HMBOX1 EYA4 PROSER1 HMG20A PRR12 KMT2D PAX8 ZFHX3 QSER1	5.24e-07	190	102	9	int:HNF1B
Interaction	SOX5 interactions	TCF20 PROSER1 HMG20A KMT2D ZFHX3 QSER1 CAPRIN1 SMAD1	1.69e-06	162	102	8	int:SOX5
Interaction	TBXT interactions	TCF20 HMG20A PRR12 KMT2D QSER1 DOT1L SPEN	2.05e-06	116	102	7	int:TBXT
Interaction	EYA4 interactions	RAF1 TCF4 EYA4 PROSER1 PRR12 ALMS1 PITX2 KBTBD13 QSER1	4.02e-06	243	102	9	int:EYA4
Interaction	GSC interactions	EYA4 PRR12 KMT2D ZFHX3 QSER1 SMAD1	5.25e-06	87	102	6	int:GSC
Interaction	CNKSR2 interactions	RAF1 DLGAP2 KALRN CAPRIN1 AGAP2	2.10e-05	66	102	5	int:CNKSR2
Interaction	PAX8 interactions	PROSER1 HMG20A PRR12 KMT2D PAX8 QSER1	2.14e-05	111	102	6	int:PAX8
Interaction	TBR1 interactions	PROSER1 HMG20A PRR12 KMT2D ZFHX3 QSER1	2.36e-05	113	102	6	int:TBR1
Interaction	SP7 interactions	EYA4 TCF20 PROSER1 HMG20A PRR12 KMT2D BRCA1 ZFR QSER1	2.41e-05	304	102	9	int:SP7
Interaction	UBAP2 interactions	RAF1 VENTX BRCA1 ZFR DOT1L CAPRIN1 ZC3HAV1	2.53e-05	170	102	7	int:UBAP2
Interaction	NUP155 interactions	UBE2J1 EYA4 NBEAL1 RHBDD2 SEC31A KMT2D ALMS1 BRCA1 MYH14 TACC1 ZC3HAV1	2.99e-05	477	102	11	int:NUP155
Interaction	TLX1 interactions	EYA4 TCF20 HMG20A PRR12 KMT2D ZFHX3 QSER1	3.05e-05	175	102	7	int:TLX1
Interaction	SMG7 interactions	TCF20 HMG20A KIAA0753 PRR12 KMT2D BRCA1 DOT1L CAPRIN1 ZC3HAV1	3.51e-05	319	102	9	int:SMG7
Interaction	TOP3B interactions	ANKS6 KALRN L1CAM DVL2 IRS1 AHDC1 NBPF1 PRR12 KMT2D SLC12A4 SETD5 ZFR DOT1L LSM14B SPEN MYRF CAPRIN1 IL4R NOTCH2 ZC3HAV1	4.10e-05	1470	102	20	int:TOP3B
Interaction	RUNX1T1 interactions	TCF4 TCF12 DVL2 CREB3L1 BRCA1 SPEN	4.57e-05	127	102	6	int:RUNX1T1
Interaction	GATA3 interactions	FHOD3 HMG20A PRR12 KMT2D BRCA1 ZFR DOT1L	4.65e-05	187	102	7	int:GATA3
Interaction	LUZP1 interactions	RAF1 EYA4 SEC31A KIAA0753 BRCA1 DOT1L AGAP2	5.87e-05	194	102	7	int:LUZP1
Interaction	KBTBD13 interactions	EYA4 KBTBD13	7.58e-05	3	102	2	int:KBTBD13
Interaction	PAX6 interactions	HMBOX1 RANBP3 HMG20A PRR12 HOXB1 KMT2D ZFHX3 QSER1 SMAD1	1.01e-04	366	102	9	int:PAX6
Interaction	SOX10 interactions	TCF4 TCF12 PROSER1 HMG20A KMT2D	1.04e-04	92	102	5	int:SOX10
Interaction	NEUROG1 interactions	TCF4 TCF12 SMAD1	1.15e-04	19	102	3	int:NEUROG1
Interaction	SOX6 interactions	TCF20 PROSER1 HMG20A ZFHX3 QSER1 CAPRIN1	1.48e-04	157	102	6	int:SOX6
Interaction	NAGK interactions	TCF12 DVL2 AHDC1 SETD5 SHISA6 SMAD9	1.75e-04	162	102	6	int:NAGK
GeneFamily	PDZ domain containing	MAGI1 PCLO DVL2 LDB3 MAST1	3.97e-04	152	74	5	1220
GeneFamily	SMAD family	SMAD1 SMAD9	4.55e-04	8	74	2	750
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	TCF4 RELN TCF12 KALRN NBEAL1 SIK1 FHOD3 IRS1 DNAAF9 KIAA0753 ALMS1 BRCA1 ACSBG1 ZFR ZFHX3 MYRF PIGO	1.17e-06	1102	102	17	M2369
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	TCF4 RELN TCF12 KALRN NBEAL1 SIK1 FHOD3 IRS1 DNAAF9 KIAA0753 ALMS1 BRCA1 ACSBG1 ZFR ZFHX3 MYRF PIGO	1.53e-06	1124	102	17	MM1070
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	RELN EYA4 IRX5 NR4A2 SNX33 FIGN CPNE5 CREB3L1 NKX1-2 SLC12A4 PROKR2 MAST1 BACE2 IL4R SHISA6 ZC3HAV1	3.90e-06	1074	102	16	M1941
Coexpression	LAKE_ADULT_KIDNEY_C25_ENDOTHELIAL_CELLS_UNASSIGNED	TCF4 TCF12 KALRN ZFHX3	1.44e-05	38	102	4	M39244
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	THSD4 MAGI1 UBE2J1 ANKS6 EYA4 TCF12 TCF20 SIK1 IRS1 MYH14 PITX2 CAPRIN1 IL4R NOTCH2	3.65e-05	1009	102	14	M157
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_200	EYA4 TBX4 IRX5 NKX1-2 PROKR2 TP63 PITX2 ZFHX3	1.47e-06	169	101	8	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_200
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_top-relative-expression-ranked_500	MAGI1 NR4A2 MUC16 SIK1 CPA2 IRS1 CREB3L1 PROKR2 NFIL3 MYRF SHISA6	6.69e-06	432	101	11	gudmap_dev gonad_e11.5_M_GonMes_Sma_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_500	MAGI1 NR4A2 MUC16 CPA2 IRS1 CREB3L1 NFIL3 BACE2 MYRF SHISA6	1.52e-05	385	101	10	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_200	EYA4 TBX4 IRX5 PROKR2 TP63 PITX2 ZFHX3	2.05e-05	175	101	7	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#2_top-relative-expression-ranked_500	TCF4 TBX4 IRX5 NKX1-2 ZFHX3	2.39e-05	72	101	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_100	TBX4 IRX5 NKX1-2 TP63 PITX2	3.53e-05	78	101	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_100
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_500	TCF4 EYA4 TBX4 IRX5 FIGN NKX1-2 PROKR2 TP63 PITX2 ZFHX3	3.74e-05	428	101	10	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_500	TCF4 EYA4 TBX4 IRX5 ZC3H6 NKX1-2 PROKR2 TP63 PITX2 ZFHX3	3.81e-05	429	101	10	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_top-relative-expression-ranked_500	MAGI1 NR4A2 MUC16 SIK1 CPA2 IRS1 CREB3L1 NFIL3 MYRF SHISA6	4.37e-05	436	101	10	gudmap_dev gonad_e11.5_F_GonMes_Sma_500
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_top-relative-expression-ranked_1000	MAGI1 KALRN NR4A2 MUC16 SIK1 CPA2 IRS1 CREB3L1 BRCA1 PROKR2 NETO2 NFIL3 MYRF SHISA6	4.86e-05	849	101	14	gudmap_dev gonad_e11.5_M_GonMes_Sma_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_ureteral tissue_emap-8234_k-means-cluster#5_top-relative-expression-ranked_200	LDB3 PITX2 TBX20	6.77e-05	17	101	3	gudmap_developingLowerUrinaryTract_e15.5_ureteral tissue_200_k5
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	MAGI1 UBE2J1 RELN TCF12 DONSON L1CAM RHBDD2 FHOD3 AKTIP ALMS1 BRCA1 SETD5 MYH14 CAPRIN2 ZFR MYRF PIGO REV1	7.45e-05	1370	101	18	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_k-means-cluster#3_top-relative-expression-ranked_1000	THSD4 RELN NR4A2 FIGN PAX8 NFIL3 ZFHX3 NOTCH2	7.96e-05	293	101	8	gudmap_kidney_P0_JuxtaGlom_Ren1_k3_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#2_top-relative-expression-ranked_1000	EYA4 IRX5 FIGN PROKR2 NETO2 PITX2	8.20e-05	150	101	6	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_1000	TCF4 TBX4 IRX5 NKX1-2 ZFHX3	1.05e-04	98	101	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_200	TBX4 IRX5 NKX1-2 TP63 PITX2 ZFHX3	1.05e-04	157	101	6	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500	RAF1 EYA4 IRX5 PCLO DVL2 CPA2 SNX33 BRCA1 PITX2 ZFHX3	1.19e-04	492	101	10	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#1	RAF1 DVL2 CPA2 SNX33	1.46e-04	56	101	4	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_200	EYA4 TBX4 NR4A2 PROKR2 PITX2 TBX20	1.48e-04	167	101	6	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_200	TBX4 NR4A2 ZC3H6 TP63 PITX2 TBX20	1.58e-04	169	101	6	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_200
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_500	NR4A2 MUC16 IRS1 NFIL3 MYRF	2.33e-04	116	101	5	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k3_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000	MAGI1 RELN ARHGEF5 PCLO L1CAM FHOD3 DNAAF9 ALMS1 BRCA1 ACSBG1 PAX8 MAST1 TACC1 PIGO	2.35e-04	986	101	14	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#3_top-relative-expression-ranked_1000	TCF4 TBX4 IRX5 NKX1-2 ZFHX3	2.52e-04	118	101	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#3_top-relative-expression-ranked_100	IRX5 NKX1-2 PITX2	2.81e-04	27	101	3	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_100_k3
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_k-means-cluster#1_top-relative-expression-ranked_500	MUC16 IRS1 CREB3L1 PROKR2 MYRF	3.29e-04	125	101	5	gudmap_dev gonad_e11.5_M_GonMes_Sma_k1_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000	MAGI1 KALRN NR4A2 MUC16 SIK1 CPA2 IRS1 CREB3L1 NFIL3 BACE2 MYRF SHISA6	4.02e-04	797	101	12	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_500	MAGI1 MUC16 CPA2 IRS1 CREB3L1 BACE2 MYRF SHISA6	4.03e-04	372	101	8	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#4_top-relative-expression-ranked_500	TBX4 IRX5 NKX1-2 ZFHX3	4.52e-04	75	101	4	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500_k4
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	KALRN MUC16 IRS1 CREB3L1 PROKR2 MYRF	4.69e-04	207	101	6	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#3_top-relative-expression-ranked_100	EYA4 NR4A2 PROKR2	5.14e-04	33	101	3	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_100_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000	TCF4 EYA4 TBX4 IRX5 FIGN ZC3H6 NKX1-2 PROKR2 TP63 PITX2 ZFR ZFHX3	6.14e-04	836	101	12	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_k-means-cluster#3_top-relative-expression-ranked_500	MUC16 SIK1 IRS1 NFIL3 MYRF	7.12e-04	148	101	5	gudmap_dev gonad_e11.5_F_GonMes_Sma_k3_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_ureteral tissue_emap-8234_top-relative-expression-ranked_500	MYBPH RELN EYA4 LDB3 TP63 PITX2 TBX20 ZC3HAV1	7.16e-04	406	101	8	gudmap_developingLowerUrinaryTract_e15.5_ureteral tissue_500
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_k-means-cluster#3_top-relative-expression-ranked_1000	KALRN MUC16 SIK1 IRS1 CREB3L1 PROKR2 MYRF	7.18e-04	311	101	7	gudmap_dev gonad_e11.5_M_GonMes_Sma_k3_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_200	TBX4 IRX5 NKX1-2	7.22e-04	37	101	3	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_200_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_k-means-cluster#4_top-relative-expression-ranked_200	TBX4 NKX1-2 PROKR2	7.22e-04	37	101	3	gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_200_k4
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_1000	TBX4 NBEAL1 FHOD3 ZC3H6 LDB3 TP63 PITX2 TACC1 BACE2 TBX20 ZC3HAV1	7.36e-04	734	101	11	gudmap_developingLowerUrinaryTract_adult_bladder_1000
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	THSD4 MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1 SMAD9	1.29e-08	185	104	8	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	THSD4 MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1 SMAD9	1.29e-08	185	104	8	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 DLGAP2 TCF4 RELN KALRN BACE2 SMAD1	3.22e-07	190	104	7	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	IPF-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1 SMAD9	3.22e-07	190	104	7	ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCell	IPF-Endothelial-Lymphatic\|IPF / Disease state, Lineage and Cell class	MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1 SMAD9	3.46e-07	192	104	7	2496edd8f3a41146d418879de9ee2ccc7857431f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THSD4 MAGI1 MUC16 FIGN CREB3L1 SYNJ2 BACE2	4.56e-07	200	104	7	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	control-Plasmablast\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	UBE2J1 TCF4 NBEAL1 CPNE5 TP63 BACE2	2.50e-06	165	104	6	61063e0ce61bc92d5d1093be8279af03f650720b
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	3.63e-06	176	104	6	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	3.63e-06	176	104	6	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN TP63 SMAD1	3.75e-06	177	104	6	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	metastatic_Lymph_Node-Endothelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	THSD4 MAGI1 DLGAP2 RELN KALRN SMAD9	3.75e-06	177	104	6	71bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN TP63 SMAD1	3.75e-06	177	104	6	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN TP63 SMAD1	3.75e-06	177	104	6	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	DLGAP2 RELN KALRN CPNE5 SMAD1 SMAD9	3.88e-06	178	104	6	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	TCF4 KALRN NBEAL1 FIGN SHISA6 AGAP2	4.55e-06	183	104	6	273db6a3b00a93ca852498471187b642b5368185
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	TCF4 KALRN NBEAL1 TACC1 SHISA6 AGAP2	4.84e-06	185	104	6	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	DLGAP2 RELN KALRN CPNE5 BACE2 SMAD1	5.15e-06	187	104	6	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DLGAP2 RELN KALRN CPNE5 BACE2 SMAD1	5.31e-06	188	104	6	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DLGAP2 RELN KALRN CPNE5 BACE2 SMAD1	5.31e-06	188	104	6	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	THSD4 MAGI1 EYA4 FHOD3 CPNE5 LDB3	5.47e-06	189	104	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	THSD4 MAGI1 EYA4 FHOD3 CPNE5 LDB3	5.64e-06	190	104	6	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	DLGAP2 RELN KALRN CPNE5 BACE2 SMAD1	5.64e-06	190	104	6	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	THSD4 MAGI1 EYA4 FHOD3 CPNE5 LDB3	5.81e-06	191	104	6	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	Control-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1	5.99e-06	192	104	6	f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCell	COPD-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1	6.17e-06	193	104	6	25bdc557055b5bce6a21f8696b48e991c696b979
ToppCell	COPD-Endothelial-Lymphatic\|COPD / Disease state, Lineage and Cell class	MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1	6.17e-06	193	104	6	18bcf08068a236c4575c7a07181ac893dfdcbeeb
ToppCell	Control-Endothelial-Lymphatic\|Control / Disease state, Lineage and Cell class	MAGI1 DLGAP2 RELN KALRN BACE2 SMAD1	6.17e-06	193	104	6	64d19be73e5432d491436a01da5de5c926b615a9
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	MAGI1 TCF4 RELN PCLO NETO2 SHISA6	6.35e-06	194	104	6	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	MAGI1 TCF4 RELN PCLO NETO2 SHISA6	6.35e-06	194	104	6	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DLGAP2 TCF4 RELN KALRN BACE2 SMAD1	6.35e-06	194	104	6	f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DLGAP2 TCF4 RELN KALRN BACE2 SMAD1	6.35e-06	194	104	6	3b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	THSD4 MAGI1 EYA4 FHOD3 CPNE5 LDB3	6.35e-06	194	104	6	c3535f7cc0076653c72db582047cff053c322397
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DLGAP2 TCF4 RELN KALRN BACE2 SMAD1	6.35e-06	194	104	6	5d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	THSD4 DLGAP2 RELN KALRN BACE2 SMAD1	6.54e-06	195	104	6	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TCF4 KALRN CPNE5 TACC1 IL4R SMAD9	6.74e-06	196	104	6	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EYA4 TBX4 KALRN FHOD3 CPNE5 LDB3	6.74e-06	196	104	6	9830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TCF4 KALRN CPNE5 TACC1 IL4R SMAD9	6.94e-06	197	104	6	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 TCF4 RELN KALRN CPNE5 SMAD1	7.14e-06	198	104	6	9ab0db78394e730f6866b2db80047149024ad5f6
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	7.14e-06	198	104	6	b3a020522e064bb61949d38e442f24026e339364
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	7.14e-06	198	104	6	fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 TCF4 RELN KALRN CPNE5 SMAD1	7.14e-06	198	104	6	e47d0e2c6353315c85d7007742bb16b0f05795ed
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Lymphatic\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	7.35e-06	199	104	6	88f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	7.35e-06	199	104	6	64b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 RELN KALRN BACE2 SMAD1 SMAD9	7.35e-06	199	104	6	1587d24b19f5bb64a3b6cc1df87c7c472cf41672
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 RELN KALRN BACE2 SMAD1 SMAD9	7.35e-06	199	104	6	a9c2041e54899cb8ccc026758647f3ae3ca457dd
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MAGI1 DLGAP2 TCF4 RELN KALRN SMAD1	7.35e-06	199	104	6	2b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TCF4 SIK1 BEND4 CPNE5 DMXL1 BACE2	7.56e-06	200	104	6	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MAGI1 TCF4 RELN BEND4 LSM14B AGAP2	7.56e-06	200	104	6	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Interneuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	TCF4 TCF12 RANBP3 BEND4 FIGN	9.62e-06	121	104	5	b2d571f571133c281d72584fe925cebbd2317829
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN CPNE5 PROKR2 SHISA6 PROP1	1.00e-05	122	104	5	eae9d94f8510ac0f434942451d55c7260977b178
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN EYA4 BEND4 NETO2 SHISA6	1.31e-05	129	104	5	f83187c0bb06528127b8d2d56674ab1946846951
ToppCell	control-Plasmablast\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TCF4 NBEAL1 CPNE5 TP63 BACE2	1.36e-05	130	104	5	9fe3c5be8488d341cff38757daf7856c112410d0
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SIK1 FIGN AHDC1 PITX2 AGAP2	1.76e-05	137	104	5	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SIK1 FIGN AHDC1 PITX2 AGAP2	1.76e-05	137	104	5	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Glra3\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN BEND4 NETO2 IL4R SHISA6	2.47e-05	147	104	5	50e86860a94be103092c40e39a172eac92372f0d
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	MARCHF10 MUC16 FOXI3 NKX1-2 CCDC201	2.80e-05	151	104	5	8216462e723fec2797387929dde095370947e10a
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	THSD4 EYA4 TBX4 IRS1 ZFHX3	3.38e-05	157	104	5	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	10x5'-Lung-Lymphocytic_B-ABC_aged-B_memory\|Lung / Manually curated celltypes from each tissue	TCF4 IRS1 BEND4 CPNE5 TP63	3.59e-05	159	104	5	d3202ddc291b8686dbe67690df13c7daffec2199
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN SMAD1	3.81e-05	161	104	5	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN SMAD1	3.81e-05	161	104	5	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	Influenza_Severe-B_memory\|World / Disease group and Cell class	TCF4 CEACAM8 MUC16 CPNE5 BACE2	3.92e-05	162	104	5	21eb96cd4fecd85dd6acbbc3760944fa1a7cff42
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN SMAD1	3.92e-05	162	104	5	2ac02523348660e514d464f8f2434ee0c312d784
ToppCell	normal-na-Lymphocytic_B-B_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TCF4 MUC16 CPNE5 LDB3 BACE2	3.92e-05	162	104	5	ae292318d339305932457bb0e91430594f7a3dfa
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DONSON ZC3H6 ALMS1 POLI AGAP2	4.04e-05	163	104	5	4af92b211d12c5b88b65bb746242cd702b545bd0
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DONSON ZC3H6 ALMS1 POLI AGAP2	4.04e-05	163	104	5	d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYBPH NR4A2 SIK1 NETO2 ZFHX3	4.16e-05	164	104	5	43630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYBPH NR4A2 SIK1 NETO2 ZFHX3	4.16e-05	164	104	5	108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYBPH NR4A2 SIK1 NETO2 ZFHX3	4.16e-05	164	104	5	46208f18325976c89f572f6627aea0582142b92d
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	DLGAP2 TCF4 RELN KALRN SMAD1	4.54e-05	167	104	5	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	THSD4 ALMS1 TACC1 QSER1 NOTCH2	4.67e-05	168	104	5	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	facs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 KALRN CAPRIN2 KBTBD13 SMAD9	5.08e-05	171	104	5	b54d9d6b03c9c6f28a71cf2ed2bfa9a335bba949
ToppCell	facs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 KALRN CAPRIN2 KBTBD13 SMAD9	5.08e-05	171	104	5	9d825a2e799421af4f2cf4f4dc8e239b5d00476d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HMG20A ALMS1 NFIL3 POLI GNA15	5.22e-05	172	104	5	ebeda7ef181cac0109be750a98e7589c615d2724
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	DLGAP2 RELN KALRN BACE2 SMAD1	5.36e-05	173	104	5	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MUC16 HOXB1 BACE2 MYRF	5.36e-05	173	104	5	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	THSD4 MAGI1 DLGAP2 RELN KALRN	5.51e-05	174	104	5	d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ANKS6 PCLO MUC16 MYH14 TP63	5.51e-05	174	104	5	9e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MUC16 HOXB1 BACE2 MYRF	5.51e-05	174	104	5	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FHOD3 LDB3 PITX2 TBX20 SHISA6	5.82e-05	176	104	5	4ed73c73972334f6dc4229920205547823252fa0
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel-D175\|Adult / Lineage, Cell type, age group and donor	TCF4 KALRN CPNE5 BACE2 SMAD1	5.98e-05	177	104	5	c9f269765c7d5d29caab75910e51645606ed562e
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLGAP2 RELN KALRN SMAD1 SMAD9	5.98e-05	177	104	5	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 CEACAM8 CPNE5 ACSBG1 PAX8	5.98e-05	177	104	5	066e7500e7bdde88a7914f50a4661d8adf6db925
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 IRX5 FIGN PAX8 SMAD9	6.14e-05	178	104	5	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF4 SIK1 CPNE5 SCML1 BACE2	6.30e-05	179	104	5	a28a1de500a74c6dcc43481abf9ec0f7e7a300a9
ToppCell	droplet-Fat-Bat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 ANKS6 KALRN KIAA0753 LDB3	6.30e-05	179	104	5	e6224864eb76a2e9c1fc0c61513d9e936bb5c72c
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MAGI1 TCF4 CPNE5 SYNJ2 TACC1	6.30e-05	179	104	5	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MAGI1 TCF4 RELN KALRN PCLO	6.30e-05	179	104	5	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	droplet-Fat-Bat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 ANKS6 KALRN KIAA0753 LDB3	6.30e-05	179	104	5	9863ab3ceb160a4b1d9790033a4ac48845863d65
ToppCell	droplet-Fat-Bat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 ANKS6 KALRN KIAA0753 LDB3	6.30e-05	179	104	5	dfe110add7228cd834b35916cbcc849769a01bb9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HMBOX1 MAGI1 IRS1 SCML1 BACE2	6.47e-05	180	104	5	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TCF4 KALRN CPNE5 TACC1 IL4R	6.47e-05	180	104	5	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 EYA4 IRS1 LDB3 SMAD9	6.64e-05	181	104	5	25915e2500430a902db37d79a749ce2990b69810
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	DLGAP2 RELN KALRN PCLO SMAD1	6.64e-05	181	104	5	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TBX4 IRS1 FIGN LDB3 TACC1	6.64e-05	181	104	5	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	DLGAP2 RELN KALRN PCLO SMAD1	6.64e-05	181	104	5	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 BEND4 CPNE5 BACE2 IL4R	6.64e-05	181	104	5	6df40f86c569b6ecfc3137a68d1355b012dbf6bf
ToppCell	normal-na-Lymphocytic_B-B_mem-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	UBE2J1 TCF4 EYA4 CPNE5 BACE2	6.82e-05	182	104	5	ee36ea6cb9a5a08aeb83f2b7a249255f0b1a9870
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN SMAD1	6.82e-05	182	104	5	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN SMAD1	6.82e-05	182	104	5	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 TCF4 RELN KALRN SMAD1	6.82e-05	182	104	5	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
Computational	Genes in the cancer module 123.	TBX4 IRX5 NR4A2 HOXB1 BRCA1 ZFHX3 SMAD1 PROP1	1.13e-04	247	65	8	MODULE_123
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 0.1uM; MCF7; HG-U133A	MAGI1 L1CAM CREB3L1 ALMS1 BRCA1 SYNJ2 PAX8 ZFR	3.21e-06	197	103	8	3_DN
Drug	Disopyramide [3737-09-5]; Down 200; 11.8uM; HL60; HT_HG-U133A	RANBP3 DVL2 KIAA0753 MYH14 SCML1 LSM14B PIGO NOTCH2	3.46e-06	199	103	8	2408_DN
Drug	LDN 193189	TP63 SMAD1 SMAD9	4.95e-06	8	103	3	ctd:C554430
Drug	Harmaline hydrochloride dihydrate [6027-98-1]; Up 200; 14uM; MCF7; HT_HG-U133A	L1CAM SIK1 CPA2 PAX8 GNA15 IL4R AGAP2	3.00e-05	195	103	7	2805_UP
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; PC3; HT_HG-U133A	TCF4 RANBP3 L1CAM AHDC1 ALMS1 PIGO ZC3HAV1	3.10e-05	196	103	7	1794_DN
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; HL60; HT_HG-U133A	RANBP3 PCLO ALMS1 SCML1 QSER1 PIGO SMAD1	3.10e-05	196	103	7	2935_DN
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; PC3; HT_HG-U133A	KALRN ADAM20 PAX8 MYH14 PIGO NOTCH2 AGAP2	3.10e-05	196	103	7	4066_UP
Drug	Zalcitabine [7481-89-2]; Down 200; 19uM; HL60; HT_HG-U133A	TCF4 RANBP3 NR4A2 QSER1 LSM14B CAPRIN1 PIGO	3.21e-05	197	103	7	2932_DN
Drug	ST021200; Down 200; 10uM; MCF7; HT_HG-U133A	AHDC1 SYNJ2 MYH14 CAPRIN2 ZFR GNA15 IL4R	3.31e-05	198	103	7	7554_DN
Drug	Cefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	MAGI1 NR4A2 SYNJ2 MYH14 TACC1 IL4R PIGO	3.31e-05	198	103	7	3426_DN
Disease	Idiopathic pulmonary hypertension	TBX4 SMAD1 SMAD9	3.32e-06	9	102	3	C0152171
Disease	stroke	DLGAP2 KALRN NBEAL1 PITX2 ZFHX3 SHISA6	1.11e-05	144	102	6	EFO_0000712
Disease	2-oxo-hept-3-ene-1,7-dioate hydratase activity	TBX4 SMAD1 SMAD9	1.42e-05	14	102	3	C1150929
Disease	Idiopathic pulmonary arterial hypertension	TBX4 SMAD1 SMAD9	2.17e-05	16	102	3	C3203102
Disease	Familial primary pulmonary hypertension	TBX4 SMAD1 SMAD9	2.63e-05	17	102	3	C0340543
Disease	Ischemic stroke, cardiac embolism	PITX2 ZFHX3	3.54e-05	3	102	2	EFO_1001493, HP_0002140
Disease	Pitt-Hopkins syndrome (implicated_via_orthology)	TCF4 TCF12	3.54e-05	3	102	2	DOID:0060488 (implicated_via_orthology)
Disease	Diffuse Large B-Cell Lymphoma	SEC31A KMT2D SPEN NOTCH2	4.01e-05	55	102	4	C0079744
Disease	asthma	THSD4 RAF1 MAGI1 EYA4 MUC16 DNAAF9 SEC31A POLI GNA15 MYRF IL4R	5.88e-05	751	102	11	MONDO_0004979
Disease	obesity (implicated_via_orthology)	TCF4 TCF12 IRS1 ALMS1 ZFHX3 NOTCH2	1.05e-04	215	102	6	DOID:9970 (implicated_via_orthology)
Disease	depressive symptom measurement	DLGAP2 TCF4 TCF20 MARCHF10 PCLO NR4A2 BEND4 PAX8	1.19e-04	426	102	8	EFO_0007006
Disease	eye disease (implicated_via_orthology)	EYA4 MYRF	1.76e-04	6	102	2	DOID:5614 (implicated_via_orthology)
Disease	Craniofacial Abnormalities	TCF4 IRX5 HOXB1 TP63 PITX2	2.14e-04	156	102	5	C0376634
Disease	prostate cancer (is_marker_for)	RAF1 KMT2D SETD5 AGAP2 SMAD9	2.14e-04	156	102	5	DOID:10283 (is_marker_for)
Disease	Familial pulmonary arterial hypertension	TBX4 SMAD9	3.27e-04	8	102	2	C1701939
Disease	sick sinus syndrome	PITX2 ZFHX3	3.27e-04	8	102	2	MONDO_0001823
Disease	familial sick sinus syndrome	PITX2 ZFHX3	3.27e-04	8	102	2	MONDO_0012061
Disease	Congenital Hand Deformities	L1CAM TP63	3.27e-04	8	102	2	C0018566
Disease	intraocular pressure measurement	TCF4 RELN TCF12 KALRN PCLO LDB3 SYNJ2 ZFHX3	3.94e-04	509	102	8	EFO_0004695
Disease	Colorectal Neoplasms	EYA4 DONSON NR4A2 PAX8 TP63 SMAD9	4.11e-04	277	102	6	C0009404
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2D BRCA1 SPEN	5.12e-04	45	102	3	DOID:3748 (is_implicated_in)
Disease	Pulmonary arterial hypertension	TBX4 SMAD9	5.23e-04	10	102	2	C2973725
Disease	Cardiomyopathy, Dilated	RAF1 SIK1 ALMS1	6.20e-04	48	102	3	C0007193
Disease	Microphthalmos	KMT2D MYRF	6.38e-04	11	102	2	C0026010
Disease	Cardiomyopathy, Familial Idiopathic	RAF1 SIK1 ALMS1	6.99e-04	50	102	3	C1449563
Disease	Colorectal Carcinoma	EYA4 DONSON KALRN NR4A2 PAX8 TP63 KDF1 PIGO SMAD9	7.43e-04	702	102	9	C0009402
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD9	9.00e-04	13	102	2	DOID:0050787 (implicated_via_orthology)
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	HMG20A GNA15	1.05e-03	14	102	2	EFO_0006830, EFO_0006896
Disease	bitter alcoholic beverage consumption measurement	TCF4 RELN SETD5 ZFHX3	1.19e-03	133	102	4	EFO_0010092
Disease	cognitive function measurement	MAGI1 TCF4 TCF20 KALRN FIGN PRR12 KMT2D ALMS1 MAST1 ZFR TACC1 BACE2 REV1	1.34e-03	1434	102	13	EFO_0008354
Disease	Abnormal behavior	NR4A2 PRR12	1.38e-03	16	102	2	C0233514
Disease	myocardial infarction	KALRN NBEAL1 FIGN AHDC1 TBX20 SMAD9	1.38e-03	350	102	6	EFO_0000612
Disease	breast carcinoma (is_marker_for)	KMT2D BRCA1 ZFHX3	1.57e-03	66	102	3	DOID:3459 (is_marker_for)
Disease	hearing loss	EYA4 DVL2 SYNJ2	1.64e-03	67	102	3	EFO_0004238
Disease	resting heart rate	FHOD3 CPNE5 TBX20 MYRF	1.81e-03	149	102	4	EFO_0004351
Disease	aortic measurement	THSD4 KALRN FIGN DOT1L TBX20	1.82e-03	251	102	5	EFO_0020865
Disease	cardiomyopathy (implicated_via_orthology)	RAF1 LDB3 TBX20	1.93e-03	71	102	3	DOID:0050700 (implicated_via_orthology)
Disease	bipolar disorder (is_marker_for)	RELN L1CAM	1.95e-03	19	102	2	DOID:3312 (is_marker_for)
Disease	colorectal cancer, inflammatory bowel disease	DLGAP2 ALMS1	1.95e-03	19	102	2	EFO_0003767, MONDO_0005575
Disease	hypothyroidism (biomarker_via_orthology)	RELN L1CAM PITX2	2.72e-03	80	102	3	DOID:1459 (biomarker_via_orthology)
Disease	wellbeing measurement	DLGAP2 TCF4 ANKS6 MARCHF10 PCLO NR4A2 FIGN ZFHX3	2.79e-03	692	102	8	EFO_0007869
Disease	otosclerosis	RELN IRX5 FHOD3	2.81e-03	81	102	3	EFO_0004213
Disease	Ovarian Serous Adenocarcinoma	RAF1 MAST1	2.86e-03	23	102	2	C1335177
Disease	gamma-linolenic acid measurement	DOT1L MYRF	3.11e-03	24	102	2	EFO_0007762
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	RELN ZFHX3	3.11e-03	24	102	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	fasting blood glucose measurement	SNX33 CREB3L1 HMG20A LSM14B BACE2	3.25e-03	287	102	5	EFO_0004465

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPSFNPFGSHSVLQN	TACC1	391	O75410
TGSSNFAVAGTPHSY	BACE2	111	Q9Y5Z0
HSYSLSGDSAPQSPL	CREB3L1	86	Q96BA8
SGSPNHVDSAYFPGS	C9orf129	91	Q5T035
SGHSQARPSQYFTSP	ADAM20	26	O43506
SGYCQAGPSQHFTSP	ADAM21	26	Q9UKJ8
HNPAFATESPAYGSS	ARHGEF5	696	Q12774
NLSCHAASNPPSQYS	CEACAM8	256	P31997
SFPTPNPSSASEYGH	BEND4	261	Q6ZU67
PAPAAQSTNGTHASY	AKTIP	56	Q9H8T0
QKTGIPSAPSSFYSH	ALMS1	896	Q8TCU4
TYGHNFILSNPSNTG	CHIA	266	Q9BZP6
ASSNPCSDSYHGPSA	CPA2	266	P48052
SDYSSSLPSSPNVGH	AGAP2	606	Q99490
SFQRHSEPSTPTQYS	DLGAP2	801	Q9P1A6
PLSQTNGAHYSPLTS	DOT1L	1171	Q8TEK3
NSLPASPSSAHSAGY	AHDC1	1006	Q5TGY3
GYTASQPLYQPSHAT	CAPRIN1	441	Q14444
AVQGTTPYTHSNPGT	DMXL1	2706	Q9Y485
SHSAALTGTFPAYPG	DVL2	381	O14641
SLHSPNSYYGSRSPQ	NBEAL1	1981	Q6ZS30
RYSTPHAFTFNTSSP	RAF1	231	P04049
GHPSADTPTATNYFL	RANBP3	286	Q9H6Z4
PHIPTSGQGSYASSA	PAX8	376	Q06710
PSLSAYQHPTTFSNR	QSER1	56	Q2KHR3
STAFTAPSPGYNSHL	IRX5	51	P78411
HTPGRTNPSFGTLYS	MUC16	221	Q8WXI7
PPSQHSYASSNAAER	NOTCH2	2386	Q04721
GSYLHSTYSSQPAPA	FIGN	191	Q5HY92
SGGQSSPFSSPFHNF	FOXI3	391	A8MTJ6
SSPADVASNSSHGYP	MAGI1	611	Q96QZ7
SAPATHTSYSEGPAA	LDB3	376	O75112
LNHPEVPYSSGATSS	HMG20A	31	Q9NP66
GSASASPFQPHVPYS	LSM14B	101	Q9BX40
IYSPDHTNNSFSSNP	TCF4	331	P15884
QTQHSGMSPSPSNSY	HMBOX1	91	Q6NT76
HYRFLTNGPSSSPGQ	MYH14	326	Q7Z406
PTQAPTSYTQQSHFE	PCLO	3896	Q9Y6V0
SFSGYSHSPPLLQVN	NFIL3	251	Q16649
GQAPSSPSYENSLHS	TCF12	381	Q99081
ISTSNGSPGFEYHQP	KALRN	2291	O60229
AVPGSAFQSSAYHTQ	KDM4E	401	B2RXH2
VYQSPHSGSFTITGN	L1CAM	86	P32004
IPTSHLATYFPSFQG	GNA15	286	P30679
SGYLSGPVAFHSSPS	IRS1	906	P35568
ITCSNSHGPYDSNQP	NBPF1	751	Q3BBV0
RNFSPNTPAHFSFAS	MAST1	66	Q9Y2H9
PSSSNSIGCSPFQFH	RELN	3161	P78509
LSSSNPSYPGFSVSN	PROSER1	781	Q86XN7
TDHAQNSVTAPSPYA	TP63	136	Q9H3D4
YPGPHSFDVSFQQSS	TP63	171	Q9H3D4
HGSQPSNSYPSIISD	BRCA1	1421	P38398
TSSGYSPRSAHQYSP	EYA4	126	O95677
PGSSFAPSSTIYANN	EYA4	241	O95677
NRGPSAYSAHSAPTS	HOXB1	16	P14653
SSSSFHPAPGNAQSS	IL4R	791	P24394
NSYHSSRPSSGSSVP	FHOD3	406	Q2V2M9
QSSIKPSPFSGNIYH	DNAAF9	996	Q5TEA3
LSETSGPHFMSSPYN	ACSBG1	476	Q96GR2
SPASSANSGNFNHSP	ANKS6	621	Q68DC2
FSSPFGYQSPSGHSE	CAPRIN2	61	Q6IMN6
VNSSYNPPASFMHSA	MARCHF10	466	Q8NA82
SQSGSFSAVLYPHEP	DONSON	491	Q9NYP3
NFYISHSPNSTAGPS	HEXB	76	P07686
ASYLSGSPMPAHFSQ	CCDC201	51	A0A1B0GTI1
FTNSNPAVSAFHSFP	POLI	646	Q9UNA4
TASNGNPSQSTSLHY	CPNE5	336	Q9HCH3
SPQGASPASQSYSYH	NR4A2	11	P43354
SGSSHAPQDVSLSYP	RBM7	86	Q9Y580
NTYSTDHASAAPPSV	SCML1	221	Q9UN30
SFATYQHSTSPGPLD	SPATA6L	311	Q8N4H0
LQGLTYNSSDSPSGH	SYNJ2	1356	O15056
PGTGALHFQTFPSYS	NKX1-2	256	Q9UD57
ITCSNSHGPYDSNQP	NBPF12	751	Q5TAG4
TSADPFYQNTPHSSR	PPP1R32	406	Q7Z5V6
NHADYSSSPAGSPGA	SNX33	66	Q8WV41
GTPGYFSSQPHSGNS	SETD5	1316	Q9C0A6
GPACPAFSAHSYTSN	SIK1B	286	A0A0B4J2F2
GPACPAFSAHSYTSN	SIK1	286	P57059
SHPSASNNSYATLGQ	SHISA6	446	Q6ZSJ9
QPLADHTSTPGYSTQ	MYBPH	386	Q13203
TSNGGHFASPNYPDS	NETO2	51	Q8NC67
HSSFGYASVQNPASN	PITX2	291	Q99697
PGYPASHDSSFQGTD	KDF1	371	Q8NAX2
YSSHPGQSDLTVPNS	KIAA0753	176	Q2KHM9
TFPSSSALSAYQHPA	PRR12	141	Q9ULL5
PAAIFYPSGAHDTSN	SLC12A4	231	Q9UP95
AFSQSPCTASYPHSP	SMAD9	196	O15198
HSPNSSYPNSPGSSS	SMAD1	186	Q15797
QFQGSSPHPQHIYSS	ZC3H6	461	P61129
PQAPAGYANVATHST	SPEN	2871	Q96T58
SRPSVQSSHFPSGSY	REV1	836	Q9UBZ9
SYAAVSTHTPAPGFL	KBTBD13	156	C9JR72
VQNHFGPNPTSSSVY	RHBDD2	306	Q6NTF9
SYGLQNSSAASFHQP	UBE2J1	226	Q9Y385
PPQDHASSLSFNFSY	PROKR2	16	Q8NFJ6
PFSPNSETLASAYHA	TCF20	1051	Q9UGU0
YSHALPSQPSTGGAF	PROP1	171	O75360
SQQPASGVAYSHPTT	ZFR	46	Q96KR1
GTSATTNPPRHNGAY	PIGO	606	Q8TEQ8
SSSSSFPGFQHPQSL	TBX20	351	Q9UMR3
HGNPGSTYLASNSTS	ZC3HAV1	341	Q7Z2W4
QSSQPPGNAHFSVYN	TBX4	461	P57082
QGYPAASSLFHSPET	THSD4	251	Q6ZMP0
YAAQHQASSPTSSPA	SEC31A	926	O94979
GSLHAPPAFYSTSSG	VENTX	161	O95231
YSAPAPSANNTASSA	ZFHX3	2391	Q15911
QSTNYTVATGNFHPS	KMT2D	2576	O14686
SAPASSASYSHGQPA	MYRF	51	Q9Y2G1