Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Language impairment	PPARGC1A ASXL1 HUWE1 RIMS2 WDR37 TRPM3 SLC9A6 SPEG BRPF1 JAG1 SORL1	1.75e-05	1178	14	11	HP:0002463
Domain	SH3_9	DOCK1 ARHGEF19 ARHGAP33	3.49e-04	78	33	3	PF14604
Domain	RRM_1	ZNF638 PPARGC1A SRSF7 U2SURP	4.75e-04	208	33	4	PF00076
Domain	Znf_PHD	DIDO1 ASXL1 BRPF1	5.49e-04	91	33	3	IPR001965
Domain	RRM	ZNF638 PPARGC1A SRSF7 U2SURP	5.57e-04	217	33	4	SM00360
Domain	ZF_PHD_2	DIDO1 ASXL1 BRPF1	6.23e-04	95	33	3	PS50016
Domain	ZF_PHD_1	DIDO1 ASXL1 BRPF1	6.42e-04	96	33	3	PS01359
Domain	RRM_dom	ZNF638 PPARGC1A SRSF7 U2SURP	6.59e-04	227	33	4	IPR000504
Domain	RRM	ZNF638 PPARGC1A SRSF7 U2SURP	6.93e-04	230	33	4	PS50102
Domain	-	ZNF638 PPARGC1A SRSF7 U2SURP	8.63e-04	244	33	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	ZNF638 PPARGC1A SRSF7 U2SURP	1.06e-03	258	33	4	IPR012677
Domain	Znf_FYVE_PHD	DIDO1 RIMS2 BRPF1	2.19e-03	147	33	3	IPR011011
Domain	SH3_1	DOCK1 ARHGEF19 ARHGAP33	2.99e-03	164	33	3	PF00018
Domain	Zinc_finger_PHD-type_CS	DIDO1 BRPF1	5.87e-03	65	33	2	IPR019786
Domain	SH3	DOCK1 ARHGEF19 ARHGAP33	6.45e-03	216	33	3	PS50002
Domain	SH3	DOCK1 ARHGEF19 ARHGAP33	6.45e-03	216	33	3	SM00326
Domain	SH3_domain	DOCK1 ARHGEF19 ARHGAP33	6.78e-03	220	33	3	IPR001452
Domain	Znf_PHD-finger	DIDO1 BRPF1	8.57e-03	79	33	2	IPR019787
Domain	Nucleotide-diphossugar_trans	CERCAM DPM1	1.05e-02	88	33	2	IPR029044
Domain	PHD	DIDO1 BRPF1	1.08e-02	89	33	2	SM00249
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	DOCK1 DIDO1 WDR37 CCDC86 CARD14 SUN1	6.13e-09	142	35	6	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	DOCK1 DIDO1 WDR37 CCDC86 CARD14 SUN1	6.40e-09	143	35	6	20198315
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ZNF638 DIDO1 HUWE1 MCM10 SRSF7 CCDC86 U2SURP SUN1	4.95e-06	989	35	8	36424410
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CDK17 DIDO1 ASXL1 HUWE1 SRSF7 CCDC86 SORL1	5.10e-06	695	35	7	23602568
Pubmed	The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.	PPARGC1A HUWE1	9.82e-06	5	35	2	28148912
Pubmed	Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing.	DIDO1 SRSF7	2.06e-05	7	35	2	30931476
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	DOCK1 ARHGEF19 HUWE1 CCDC86 BRPF1 ARHGAP33 SORL1	3.03e-05	916	35	7	32203420
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	CCDC86 DPM1 U2SURP	5.31e-05	72	35	3	33106477
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF638 DIDO1 PPARGC1A HUWE1 OTULINL SUN1 TET1	8.78e-05	1084	35	7	11544199
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZNF638 DIDO1 HUWE1 SRSF7 CCDC86 BRPF1	1.11e-04	774	35	6	15302935
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DIDO1 HUWE1 U2SURP	1.59e-04	104	35	3	9205841
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	DIDO1 LIME1 ASXL1 DPM1 JAG1	1.60e-04	517	35	5	11780052
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DIDO1 RIMS2 WDR37 SUN1 TET1	1.78e-04	529	35	5	14621295
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ZNF638 SRSF7 CCDC86 DPM1 BRPF1 U2SURP	1.82e-04	847	35	6	35850772
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	HUWE1 JAG1	2.04e-04	21	35	2	19686682
Pubmed	Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.	BRPF1 JAG1	2.24e-04	22	35	2	25641696
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ZNF638 HUWE1 SRSF7 U2SURP	2.70e-04	313	35	4	38270169
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 ZNF638 HUWE1 SRSF7 U2SURP	2.76e-04	582	35	5	20467437
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	ZNF638 DIDO1 U2SURP	3.06e-04	130	35	3	35545047
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	RIMS2 WDR37 ARHGAP33	3.20e-04	132	35	3	16944949
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DIDO1 SRSF7 WDR37 CCDC86 DPM1	3.20e-04	601	35	5	33658012
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ASXL1 HUWE1 OTULINL BRPF1	3.38e-04	332	35	4	37433992
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	ZNF638 HUWE1 CCDC86 SUN1	3.38e-04	332	35	4	25693804
Pubmed	Tagging genes with cassette-exchange sites.	DIDO1 MCM10 SUN1 TET1	3.50e-04	335	35	4	15741177
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CERCAM HUWE1 DPM1 SUN1 SORL1	3.51e-04	613	35	5	22268729
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	ZNF638 PPARGC1A SRSF7 U2SURP	3.99e-04	347	35	4	16033648
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	DPM1 ARHGAP33 SUN1	4.05e-04	143	35	3	32560809
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	PLEKHH1 PPARGC1A	4.20e-04	30	35	2	39366945
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	ZNF638 DIDO1 HUWE1 SRSF7 CCDC86 DPM1 U2SURP	4.49e-04	1415	35	7	28515276
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZNF638 DIDO1 HUWE1 CCDC86 U2SURP	4.68e-04	653	35	5	22586326
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZNF638 HUWE1 SRSF7 CCDC86 U2SURP SUN1	5.02e-04	1024	35	6	24711643
Pubmed	Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.	JAG1 TET1	5.09e-04	33	35	2	36522157
Pubmed	Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.	CYS1 JAG1	6.07e-04	36	35	2	25715395
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	ZNF638 DIDO1 CCDC86 U2SURP	6.43e-04	394	35	4	27248496
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	DIDO1 HUWE1 CCDC86 CARD14	6.56e-04	396	35	4	26687479
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF638 DIDO1 SRSF7 CCDC86 ARHGAP33 U2SURP	6.70e-04	1082	35	6	38697112
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	HUWE1 SRSF7 CCDC86 U2SURP	7.00e-04	403	35	4	35253629
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHH1 ASXL1 SLC9A6 SPEG	7.26e-04	407	35	4	12693553
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	SRSF7 CCDC86 U2SURP	8.16e-04	182	35	3	26527279
Pubmed	A gene expression resource generated by genome-wide lacZ profiling in the mouse.	ASXL1 DPM1	9.06e-04	44	35	2	26398943
Interaction	SRSF4 interactions	ZNF638 PPARGC1A HUWE1 SRSF7 CCDC86 U2SURP	1.17e-05	300	35	6	int:SRSF4
GeneFamily	RNA binding motif containing	ZNF638 PPARGC1A SRSF7 U2SURP	1.65e-04	213	24	4	725
GeneFamily	PHD finger proteins	DIDO1 BRPF1	6.30e-03	90	24	2	88
GeneFamily	PDZ domain containing	RIMS2 CARD14	1.72e-02	152	24	2	1220
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	ZNF638 DIDO1 ASXL1 WDR37 SLC9A6	4.65e-05	300	35	5	M8702
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK1 ZNF638 CDK17 ASXL1 SRSF7 WDR37 U2SURP	1.17e-04	856	35	7	M4500
Coexpression	GSE13738_RESTING_VS_TCR_ACTIVATED_CD4_TCELL_UP	SRSF7 WDR37 SUN1 SORL1	1.30e-04	195	35	4	M3319
Coexpression	GSE360_CTRL_VS_T_GONDII_DC_UP	DOCK1 SLC9A6 BRPF1 SORL1	1.40e-04	199	35	4	M5147
Coexpression	GSE16385_ROSIGLITAZONE_IL4_VS_IFNG_TNF_STIM_MACROPHAGE_UP	CDK17 ASXL1 SLC9A6 SUN1	1.43e-04	200	35	4	M8030
Coexpression	GSE13484_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_UP	WDR37 BRPF1 SUN1 SORL1	1.43e-04	200	35	4	M3277
Coexpression	GSE14908_ATOPIC_VS_NONATOPIC_PATIENT_HDM_STIM_CD4_TCELL_DN	ZNF638 CERCAM CCDC86 TET1	1.43e-04	200	35	4	M7097
Coexpression	GSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_DN	PLEKHH1 DIDO1 ASXL1 SLC9A6	1.43e-04	200	35	4	M3067
Coexpression	GSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_DN	CDK17 DIDO1 ASXL1 MCM10	1.43e-04	200	35	4	M3074
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_500_k-means-cluster#3	PLEKHH1 PPARGC1A RIMS2 TET1	4.65e-05	118	36	4	Facebase_RNAseq_e8.5_Floor Plate_500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	PLEKHH1 ZNF638 PPARGC1A RIMS2 TET1	7.19e-05	259	36	5	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#2_top-relative-expression-ranked_1000	PPARGC1A HUWE1 RIMS2 U2SURP	1.18e-04	150	36	4	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000_k2
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_200	PPARGC1A HUWE1 CYS1 SORL1	1.37e-04	156	36	4	gudmap_developingKidney_e15.5_cortic collect duct_200
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#2_top-relative-expression-ranked_500	PPARGC1A CYS1 SORL1	1.58e-04	62	36	3	gudmap_developingKidney_e15.5_500_k2
Disease	Corneal Opacity	WDR37 JAG1	8.19e-06	4	35	2	C0010038
Disease	Moyamoya disease	DOCK1 CARD14	1.04e-03	40	35	2	MONDO_0016820
Disease	Schizophrenia	PPARGC1A RIMS2 CCDC86 JAG1 TET1	3.66e-03	883	35	5	C0036341
Disease	gut microbiome measurement, bone density	DOCK1 PPARGC1A	3.88e-03	78	35	2	EFO_0003923, EFO_0007874
Disease	aspartate aminotransferase measurement	ZNF638 PPARGC1A ARHGEF19 TRPM3 SUN1	4.04e-03	904	35	5	EFO_0004736
Disease	dilated cardiomyopathy (implicated_via_orthology)	PPARGC1A JAG1	4.08e-03	80	35	2	DOID:12930 (implicated_via_orthology)
Disease	monocyte count	DIDO1 ASXL1 JAG1 U2SURP S1PR4 SORL1	4.22e-03	1320	35	6	EFO_0005091
Disease	thyroxine measurement	DIDO1 PPARGC1A	4.38e-03	83	35	2	EFO_0005130
Disease	pulse pressure measurement	ZNF638 PPARGC1A CERCAM TRPM3 JAG1 TET1	5.46e-03	1392	35	6	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGSGSSRSSRTLRRR	CYS1	1	Q717R9
MRSAARRGRAAPAAR	ARSD	1	P51689
MDTPLRRSRRLGGLR	CCDC86	1	Q9H6F5
MASLEVSRSPRRSRR	DPM1	1	O60762
TAMSRARREDLPSLR	ASXL1	711	Q8IXJ9
PERRRFSASELMTRL	ARHGEF19	191	Q8IW93
SGLRLRRPRVSSTEM	MCM10	251	Q7L590
PMSRRSRRASLSEIG	CDK17	171	Q00537
ARMSRRTRGPVERAA	C6orf223	111	Q8N319
PAMRRRRSSDPLGDT	HUWE1	641	Q7Z6Z7
MAATRSPTRARERER	OTULINL	1	Q9NUU6
SLFSQRPQRMRSRSR	PPARGC1A	556	Q9UBK2
RPSRQRSISERRAAM	RIMS2	421	Q9UQ26
AGLLRTFMRSRPSRQ	ARHGAP33	286	O14559
SESGVLMRRRPARRI	CARD14	551	Q9BXL6
IMPSSLDDRRGSRPR	DOCK1	1616	Q14185
LDDRRGSRPRSMVRS	DOCK1	1621	Q14185
ARRRGRRSMPVSLED	DIDO1	81	Q9BTC0
RLASRPQGGRLMSSR	LINC01554	66	Q52M75
SLARRPDRRERMLAS	CERCAM	326	Q5T4B2
SRSRMAARLLGRLTP	FAM27D1	171	Q5T7N8
FRGSRSLSFRMREPL	S1PR4	361	O95977
MRSPRTRGRSGRPLS	JAG1	1	P78504
MATRSSRRESRLPFL	SORL1	1	Q92673
LRRGVGSSPRARRLM	SLC9A6	11	Q92581
QRRSMDAPSRRNRSS	U2SURP	241	O15042
MSRSRHARPSRLVRK	TET1	1	Q8NFU7
MSSLRQRKRGRSPRP	BRPF1	936	P55201
PRMRRRLSDGSLSSR	AVPR1B	361	P47901
RGSPVLAMRRRLSFT	SPEG	2446	Q15772
PEGRGDSLSMRRLSR	TRPM3	1706	Q9HCF6
RVRVELSTGMPRRSR	SRSF7	76	Q16629
RTLRTGEREARPSRM	PLEKHH1	966	Q9ULM0
MSRLLPLLRSRTARS	TMEM65	1	Q6PI78
DMSGVRLARLPRSSR	WDR37	436	Q9Y2I8
FDSPRMSRRSLRLAT	SUN1	46	O94901
PERMSRRSVRSSDRK	ZNF638	561	Q14966
RSSRALRPASMDLLR	LIME1	86	Q9H400