Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	unmethylated CpG binding	KDM2B FBXL19	1.74e-04	10	40	2	GO:0045322
GeneOntologyMolecularFunction	zinc ion binding	KDM2B PARP1 ZFHX3 FBXL19 TRIP12 TET3 TRIM44 LTN1	3.28e-04	891	40	8	GO:0008270
GeneOntologyMolecularFunction	U6 snRNA binding	EIF5A EIF5AL1	5.87e-04	18	40	2	GO:0017070
GeneOntologyMolecularFunction	translation elongation factor activity	EIF5A EIF5AL1	7.27e-04	20	40	2	GO:0003746
GeneOntologyMolecularFunction	histone demethylase activity	KDM2B FBXL19	1.75e-03	31	40	2	GO:0032452
GeneOntologyMolecularFunction	ribosome binding	EIF5A EIF5AL1 LTN1	1.78e-03	120	40	3	GO:0043022
GeneOntologyMolecularFunction	protein demethylase activity	KDM2B FBXL19	1.87e-03	32	40	2	GO:0140457
GeneOntologyMolecularFunction	transition metal ion binding	KDM2B PARP1 ZFHX3 FBXL19 TRIP12 TET3 TRIM44 LTN1	2.15e-03	1189	40	8	GO:0046914
GeneOntologyMolecularFunction	histone deacetylase binding	ZMYND15 PARP1 HDAC5	3.16e-03	147	40	3	GO:0042826
GeneOntologyMolecularFunction	demethylase activity	KDM2B FBXL19	3.51e-03	44	40	2	GO:0032451
GeneOntologyMolecularFunction	molecular adaptor activity	KDM2B HTATSF1 SMARCC2 FBXL19 HDAC5 PBXIP1 AKAP12 PCNT	4.83e-03	1356	40	8	GO:0060090
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	PARP1 PPID	5.05e-03	53	40	2	GO:0030331
GeneOntologyMolecularFunction	transcription coregulator activity	KDM2B SMARCC2 FBXL19 HDAC5 PBXIP1	5.06e-03	562	40	5	GO:0003712
GeneOntologyMolecularFunction	snRNA binding	EIF5A EIF5AL1	5.82e-03	57	40	2	GO:0017069
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	PARP1 HDAC5 TRIP12 PPID PBXIP1	5.86e-03	582	40	5	GO:0140297
GeneOntologyMolecularFunction	nuclear receptor binding	PARP1 TRIP12 PPID	6.19e-03	187	40	3	GO:0016922
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF213 TRIP12 TRIM44 LTN1	6.38e-03	372	40	4	GO:0061630
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM2B TET3	7.52e-03	65	40	2	GO:0016706
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	KDM2B HTATSF1 SMARCC2 FBXL19 HDAC5 PBXIP1 AKAP12	7.58e-03	1160	40	7	GO:0030674
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF213 TRIP12 TRIM44 LTN1	8.07e-03	398	40	4	GO:0061659
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	EIF5A EIF5AL1 LTN1	8.07e-03	206	40	3	GO:0043021
GeneOntologyBiologicalProcess	chromatin organization	KDM2B HTATSF1 SMARCC2 CHD7 TSPYL1 FBXL19 HDAC5 TRIP12 BAZ2B TET3 SMC6	5.36e-07	896	39	11	GO:0006325
GeneOntologyBiologicalProcess	protein-DNA complex organization	KDM2B HTATSF1 SMARCC2 CHD7 TSPYL1 FBXL19 HDAC5 TRIP12 BAZ2B TET3 SMC6	1.56e-06	999	39	11	GO:0071824
GeneOntologyBiologicalProcess	chromatin remodeling	KDM2B SMARCC2 CHD7 TSPYL1 FBXL19 HDAC5 TRIP12 BAZ2B TET3	7.64e-06	741	39	9	GO:0006338
GeneOntologyBiologicalProcess	positive regulation of translational termination	EIF5A EIF5AL1	2.09e-05	4	39	2	GO:0045905
GeneOntologyBiologicalProcess	positive regulation of translational elongation	EIF5A EIF5AL1	3.47e-05	5	39	2	GO:0045901
GeneOntologyBiologicalProcess	regulation of translational termination	EIF5A EIF5AL1	1.24e-04	9	39	2	GO:0006449
GeneOntologyBiologicalProcess	protein demethylation	KDM2B FBXL19	1.55e-04	10	39	2	GO:0006482
GeneOntologyBiologicalProcess	protein dealkylation	KDM2B FBXL19	1.55e-04	10	39	2	GO:0008214
GeneOntologyCellularComponent	nuclear body	PARP1 ZFHX3 AMER1 ALX1 EIF4ENIF1 HDAC5 TRIP12 SMC6	2.64e-04	903	40	8	GO:0016604
GeneOntologyCellularComponent	annulate lamellae	EIF5A EIF5AL1	3.20e-04	14	40	2	GO:0005642
GeneOntologyCellularComponent	site of double-strand break	HTATSF1 PARP1 SMC6	9.50e-04	101	40	3	GO:0035861
MousePheno	abnormal head development	KDM2B CHD7 ALX1 ALDH1A3 FBXL19	2.67e-07	62	32	5	MP:0012176
MousePheno	abnormal head mesenchyme morphology	KDM2B ALX1 ALDH1A3 FBXL19	1.13e-06	35	32	4	MP:0011260
MousePheno	abnormal periocular mesenchyme morphology	ALX1 ALDH1A3	5.08e-06	2	32	2	MP:0004054
MousePheno	abnormal periocular mesenchyme apoptosis	ALX1 ALDH1A3	5.08e-06	2	32	2	MP:0030325
MousePheno	decreased susceptibility to noise-induced hearing loss	PARP1 CHD7	3.04e-05	4	32	2	MP:0004925
MousePheno	abnormal mesenchyme morphology	KDM2B ALX1 ALDH1A3 FBXL19	3.17e-05	80	32	4	MP:0006301
MousePheno	short retina cone cell outer segment	CHD7 SLC24A1	1.06e-04	7	32	2	MP:0014333
MousePheno	abnormal internal nares morphology	CHD7 ALDH1A3	1.06e-04	7	32	2	MP:0002236
Domain	IF5A_HYPUSINE	EIF5A EIF5AL1	1.27e-05	3	39	2	PS00302
Domain	eIF-5a	EIF5A EIF5AL1	1.27e-05	3	39	2	PF01287
Domain	Transl_elong_IF5A_C	EIF5A EIF5AL1	1.27e-05	3	39	2	IPR020189
Domain	Trans_elong_IF5A_hypusine_site	EIF5A EIF5AL1	1.27e-05	3	39	2	IPR019769
Domain	PHD_4	KDM2B FBXL19	1.27e-05	3	39	2	PF16866
Domain	Transl_elong_IF5A	EIF5A EIF5AL1	1.27e-05	3	39	2	IPR001884
Domain	eIF-5a	EIF5A EIF5AL1	1.27e-05	3	39	2	SM01376
Domain	zf-CXXC	KDM2B FBXL19	2.31e-04	11	39	2	PF02008
Domain	Znf_CXXC	KDM2B FBXL19	2.31e-04	11	39	2	IPR002857
Domain	ZF_CXXC	KDM2B FBXL19	2.31e-04	11	39	2	PS51058
Domain	Translation_prot_SH3-like	EIF5A EIF5AL1	5.66e-04	17	39	2	IPR008991
Domain	Znf_PHD-finger	KDM2B FBXL19 BAZ2B	5.96e-04	79	39	3	IPR019787
Domain	Rib_L2_dom2	EIF5A EIF5AL1	6.36e-04	18	39	2	IPR014722
Domain	-	EIF5A EIF5AL1	6.36e-04	18	39	2	2.30.30.30
Domain	Leu-rich_rpt_Cys-con_subtyp	KDM2B FBXL19	7.10e-04	19	39	2	IPR006553
Domain	LRR_CC	KDM2B FBXL19	7.10e-04	19	39	2	SM00367
Domain	PHD	KDM2B FBXL19 BAZ2B	8.44e-04	89	39	3	SM00249
Domain	CRAL_TRIO	TRIO KALRN	8.70e-04	21	39	2	PF00650
Domain	Znf_PHD	KDM2B FBXL19 BAZ2B	9.01e-04	91	39	3	IPR001965
Domain	ZF_PHD_2	KDM2B FBXL19 BAZ2B	1.02e-03	95	39	3	PS50016
Domain	-	TRIO KALRN	1.05e-03	23	39	2	3.40.525.10
Domain	Spectrin	TRIO KALRN	1.05e-03	23	39	2	PF00435
Domain	ZF_PHD_1	KDM2B FBXL19 BAZ2B	1.05e-03	96	39	3	PS01359
Domain	SEC14	TRIO KALRN	1.24e-03	25	39	2	SM00516
Domain	CRAL_TRIO	TRIO KALRN	1.44e-03	27	39	2	PS50191
Domain	CRAL-TRIO_dom	TRIO KALRN	1.55e-03	28	39	2	IPR001251
Domain	BRCT_dom	SMARCC2 PARP1	1.55e-03	28	39	2	IPR001357
Domain	Spectrin_repeat	TRIO KALRN	1.66e-03	29	39	2	IPR002017
Domain	Spectrin/alpha-actinin	TRIO KALRN	2.03e-03	32	39	2	IPR018159
Domain	SPEC	TRIO KALRN	2.03e-03	32	39	2	SM00150
Domain	CHROMO	SMARCC2 CHD7	2.15e-03	33	39	2	SM00298
Domain	Chromo/shadow_dom	SMARCC2 CHD7	2.15e-03	33	39	2	IPR000953
Domain	-	KDM2B RNF213 FBXL19 BAZ2B LTN1	2.31e-03	449	39	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KDM2B RNF213 FBXL19 BAZ2B LTN1	2.54e-03	459	39	5	IPR013083
Domain	-	TIGD3 SMARCC2 ZFHX3 ALX1	2.80e-03	283	39	4	1.10.10.60
Domain	Znf_FYVE_PHD	KDM2B FBXL19 BAZ2B	3.55e-03	147	39	3	IPR011011
Domain	SANT	SMARCC2 CHD7	4.89e-03	50	39	2	SM00717
Domain	Homeodomain-like	TIGD3 SMARCC2 ZFHX3 ALX1	4.94e-03	332	39	4	IPR009057
Domain	FBOX	KDM2B FBXL19	5.27e-03	52	39	2	SM00256
Domain	SANT/Myb	SMARCC2 CHD7	5.27e-03	52	39	2	IPR001005
Domain	DH_1	TRIO KALRN	7.66e-03	63	39	2	PS00741
Pathway	REACTOME_HYPUSINE_SYNTHESIS_FROM_EIF5A_LYSINE	EIF5A EIF5AL1	4.07e-05	5	29	2	MM14823
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	EIF5A EIF5AL1 PARP1 ZFHX3 CHD7 PPID BAZ2B AKAP12	3.74e-09	332	40	8	30595499
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KDM2B FBXL19 TET3	1.68e-07	10	40	3	29276034
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM2B ZFHX3 CHD7 EIF4ENIF1 HDAC5 ACACB PCNT	4.56e-07	418	40	7	34709266
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	HTATSF1 CHD7 EIF4ENIF1 HDAC5 ACACB TRIP12 PCNT	5.51e-07	430	40	7	35044719
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM2B SMARCC2 CHD7 HDAC5 BAZ2B	1.02e-06	157	40	5	30186101
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EIF5A HTATSF1 SMARCC2 EIF5AL1 PARP1 CHD7 TRIP12 BAZ2B SMC6	1.08e-06	954	40	9	36373674
Pubmed	Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.	EIF5A EIF5AL1	1.29e-06	2	40	2	37047039
Pubmed	Targeted inhibition of eIF5Ahpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.	EIF5A EIF5AL1	1.29e-06	2	40	2	37653021
Pubmed	Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria.	CHD7 KALRN	1.29e-06	2	40	2	28152519
Pubmed	Identification of a new member of the human eIF-5A gene family.	EIF5A EIF5AL1	1.29e-06	2	40	2	7622067
Pubmed	Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.	EIF5A EIF5AL1	1.29e-06	2	40	2	8253832
Pubmed	Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.	EIF5A EIF5AL1	1.29e-06	2	40	2	31130465
Pubmed	CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.	CHD7 ALDH1A3	1.29e-06	2	40	2	29467333
Pubmed	Independent roles of eIF5A and polyamines in cell proliferation.	EIF5A EIF5AL1	1.29e-06	2	40	2	15377278
Pubmed	Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.	EIF5A EIF5AL1	1.29e-06	2	40	2	3095320
Pubmed	Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.	EIF5A EIF5AL1	1.29e-06	2	40	2	2492279
Pubmed	The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein.	EIF5A EIF5AL1	1.29e-06	2	40	2	17707773
Pubmed	Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.	EIF5A EIF5AL1	1.29e-06	2	40	2	12894223
Pubmed	Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.	EIF5A EIF5AL1	1.29e-06	2	40	2	37743008
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	1.29e-06	2	40	2	26858404
Pubmed	Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A).	EIF5A EIF5AL1	1.29e-06	2	40	2	11742107
Pubmed	The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.	EIF5A EIF5AL1	1.29e-06	2	40	2	20501948
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ARFGEF3 RNF213 ZFHX3 AMER1 ACACB TRIP12 AKAP12 SMC6	2.45e-06	777	40	8	35844135
Pubmed	Interaction network of human early embryonic transcription factors.	KDM2B SMARCC2 ZFHX3 CHD7 HDAC5 ACACB	2.91e-06	351	40	6	38297188
Pubmed	Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.	EIF5A EIF5AL1	3.87e-06	3	40	2	16519677
Pubmed	Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.	EIF5A EIF5AL1	3.87e-06	3	40	2	37333770
Pubmed	Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.	EIF5A EIF5AL1	3.87e-06	3	40	2	36893894
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	3.87e-06	3	40	2	31801062
Pubmed	Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.	EIF5A EIF5AL1	3.87e-06	3	40	2	11161802
Pubmed	Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.	EIF5A EIF5AL1	3.87e-06	3	40	2	32817651
Pubmed	Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.	EIF5A EIF5AL1	3.87e-06	3	40	2	21850436
Pubmed	The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.	EIF5A EIF5AL1	3.87e-06	3	40	2	20181941
Pubmed	The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.	PARP1 TRIP12	3.87e-06	3	40	2	32755579
Pubmed	Evidences of a role for eukaryotic translation initiation factor 5A (eIF5A) in mouse embryogenesis and cell differentiation.	EIF5A EIF5AL1	3.87e-06	3	40	2	20458750
Pubmed	New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.	EIF5A EIF5AL1	3.87e-06	3	40	2	36848144
Pubmed	Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging.	EIF5A EIF5AL1	3.87e-06	3	40	2	12210765
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	KDM2B SMARCC2 PARP1 CHD7 TRIP12 BAZ2B SMC6	5.45e-06	608	40	7	36089195
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ARFGEF3 RNF213 AKAP12 LTN1	6.35e-06	104	40	4	31240132
Pubmed	The genomic structure encoding human initiation factor eIF-5A.	EIF5A EIF5AL1	7.73e-06	4	40	2	7545941
Pubmed	The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2.	EIF5A EIF5AL1	7.73e-06	4	40	2	7759117
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	EIF5A HTATSF1 SMARCC2 EIF5AL1 PARP1 EIF4ENIF1	8.68e-06	425	40	6	24999758
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	HTATSF1 SMARCC2 EIF4ENIF1 AKAP12 TMCC2	9.14e-06	246	40	5	15345747
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	SMARCC2 RNF213 PARP1 TRIP12 LTN1	9.88e-06	250	40	5	33536335
Pubmed	Biological Relevance and Therapeutic Potential of the Hypusine Modification System.	EIF5A EIF5AL1	1.29e-05	5	40	2	26037925
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	TRIO KALRN	1.29e-05	5	40	2	18936096
Pubmed	Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.	EIF5A EIF5AL1	1.29e-05	5	40	2	34688659
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EIF5A HTATSF1 SMARCC2 RNF213 PARP1 PPID TCEAL4 SMC6	1.71e-05	1014	40	8	32416067
Pubmed	circEPB41L2 blocks the progression and metastasis in non-small cell lung cancer by promoting TRIP12-triggered PTBP1 ubiquitylation.	PARP1 TRIP12	1.93e-05	6	40	2	38341427
Pubmed	FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.	KDM2B HDAC5	2.70e-05	7	40	2	33450359
Pubmed	CHD7 cooperates with PBAF to control multipotent neural crest formation.	SMARCC2 CHD7	3.60e-05	8	40	2	20130577
Pubmed	PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.	KDM2B PARP1	3.60e-05	8	40	2	29985131
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EIF5A ARFGEF3 SMARCC2 EIF5AL1 ACACB TRIO KALRN TMCC2	3.91e-05	1139	40	8	36417873
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	PARP1 TRIP12 BAZ2B SMC6 PCNT	4.31e-05	340	40	5	29478914
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	EIF5A AMER1 EIF4ENIF1 ACACB TRIO PPID PCNT	4.79e-05	853	40	7	28718761
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ARFGEF3 KDM2B EIF5AL1 CHD7 HDAC5 PCNT	5.36e-05	588	40	6	38580884
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	ALX1 ACACB SLC24A1 BAZ2B TTC23L	5.72e-05	361	40	5	18976975
Pubmed	Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.	EIF5A EIF5AL1	5.77e-05	10	40	2	10944119
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	EIF5A FGB EIF5AL1 CHD7 BAZ2B AKAP12	7.44e-05	624	40	6	18554416
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	KDM2B SMARCC2 CHD7 ALX1 ACACB LMOD2	8.40e-05	638	40	6	31182584
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SMARCC2 PARP1 CHD7 TSPYL1 TRIP12	8.64e-05	394	40	5	27248496
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KDM2B SMARCC2 PARP1 CHD7 PPID	9.06e-05	398	40	5	35016035
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	HTATSF1 PARP1 HDAC5 PPID	9.07e-05	205	40	4	27976729
Pubmed	Identification and Characterization of USP7 Targets in Cancer Cells.	TRIP12 TCEAL4	9.98e-05	13	40	2	30367141
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	SMARCC2 PARP1 CHD7	1.01e-04	78	40	3	28611094
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SMARCC2 PARP1 CHD7 TRIO KALRN AKAP12 PCNT	1.02e-04	963	40	7	28671696
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TRIO TRIP12 PCNT LTN1	1.03e-04	212	40	4	33853758
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CHD7 HDAC5 TMCC2 PCNT	1.30e-04	225	40	4	12168954
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	RNF213 FBXL19 TRIP12	1.30e-04	85	40	3	19028597
Pubmed	Multiple roles for Pax2 in the embryonic mouse eye.	PARP1 ALDH1A3	1.34e-04	15	40	2	33428890
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	EIF5A EIF4ENIF1 ACACB PPID PBXIP1 TCEAL4 AKAP12	1.35e-04	1007	40	7	34597346
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SMARCC2 PARP1 ACACB TRIP12	1.51e-04	234	40	4	36243803
Pubmed	Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.	EIF5A EIF5AL1	1.53e-04	16	40	2	16880268
Pubmed	A gene expression atlas of early craniofacial development.	ALX1 ALDH1A3	1.53e-04	16	40	2	24780627
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	AMER1 TSPYL1 EIF4ENIF1 HDAC5 ACACB	1.54e-04	446	40	5	24255178
Pubmed	Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development.	EIF5A EIF5AL1	1.73e-04	17	40	2	33811703
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	RNF213 TRIP12 LTN1	1.81e-04	95	40	3	29643511
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	HTATSF1 SMARCC2 CHD7 HDAC5 TRIP12	1.95e-04	469	40	5	27634302
Pubmed	PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.	KDM2B FBXL19	1.95e-04	18	40	2	28614300
Pubmed	TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.	PARP1 TRIP12	1.95e-04	18	40	2	34729304
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CHD7 AMER1 TRIP12 AKAP12 SMC6 PCNT LTN1	2.13e-04	1084	40	7	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TIGD3 FBXL19 EIF4ENIF1 TRIO KALRN TMCC2 PCNT	2.39e-04	1105	40	7	35748872
Pubmed	CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.	CHD7 ALX1	2.42e-04	20	40	2	33127760
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	FGB SMARCC2 RNF213 ZFHX3 TSPYL1 EIF4ENIF1 LTN1	2.54e-04	1116	40	7	31753913
Pubmed	TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.	SMARCC2 PARP1	2.94e-04	22	40	2	17803295
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PARP1 ZFHX3 CHD7 TRIP12	3.11e-04	283	40	4	30585729
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	PARP1 KALRN	3.50e-04	24	40	2	16620772
Pubmed	Chromatin regulation by Brg1 underlies heart muscle development and disease.	PARP1 HDAC5	3.80e-04	25	40	2	20596014
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ARFGEF3 RNF213 CHD7 KALRN TCEAL4	4.11e-04	552	40	5	10737800
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	SMARCC2 PARP1 TSPYL1	4.35e-04	128	40	3	23858473
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	HTATSF1 SMARCC2 PARP1	4.46e-04	129	40	3	23022380
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SMARCC2 PARP1 CHD7 TRIP12 PCNT	5.23e-04	582	40	5	20467437
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	PARP1 HDAC5	5.50e-04	30	40	2	17403666
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KDM2B HTATSF1 PARP1 CHD7 TRIP12 BAZ2B TET3	6.17e-04	1294	40	7	30804502
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	EIF5A SMARCC2 PARP1 TRIO TRIP12 PPID AKAP12	6.26e-04	1297	40	7	33545068
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	HTATSF1 SMARCC2 PARP1	6.91e-04	150	40	3	28242625
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	AMER1 FBXL19 EIF4ENIF1 HDAC5 PPID AKAP12 SMC6	6.97e-04	1321	40	7	27173435
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	PARP1 ZFHX3 CHD7	7.18e-04	152	40	3	28192407
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	EIF5A SMARCC2 PARP1 AMER1 TSPYL1 LMOD2 PBDC1	7.42e-04	1335	40	7	29229926
Pubmed	A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.	PARP1 TSPYL1	7.49e-04	35	40	2	23382074
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ARFGEF3 HTATSF1 AMER1 TRIP12	7.77e-04	361	40	4	26167880
Interaction	TFE3 interactions	EIF5A PARP1 ZFHX3 CHD7 HDAC5 PPID BAZ2B AKAP12	3.17e-07	344	40	8	int:TFE3
Interaction	LSM1 interactions	FGB HTATSF1 ZFHX3 EIF4ENIF1 BAZ2B	2.08e-06	106	40	5	int:LSM1
Interaction	PHF21A interactions	KDM2B ZFHX3 CHD7 EIF4ENIF1 HDAC5 ACACB PCNT	4.48e-06	343	40	7	int:PHF21A
Interaction	SOX9 interactions	KDM2B SMARCC2 CHD7 HDAC5	4.03e-05	97	40	4	int:SOX9
Interaction	GATA2 interactions	KDM2B SMARCC2 ZFHX3 CHD7 HDAC5	4.44e-05	199	40	5	int:GATA2
Interaction	RCOR1 interactions	KDM2B SMARCC2 ZFHX3 CHD7 EIF4ENIF1 HDAC5 ACACB	4.71e-05	494	40	7	int:RCOR1
Interaction	H3C3 interactions	KDM2B SMARCC2 PARP1 CHD7 TRIP12 BAZ2B SMC6	4.77e-05	495	40	7	int:H3C3
Interaction	ERG interactions	KDM2B SMARCC2 PARP1 CHD7 TRIP12	7.61e-05	223	40	5	int:ERG
Interaction	EED interactions	EIF5A KDM2B SMARCC2 PARP1 CHD7 ACACB TRIO TRIP12 BAZ2B PCNT LTN1	8.23e-05	1445	40	11	int:EED
Interaction	COIL interactions	KDM2B HTATSF1 PARP1 CHD7 TSPYL1 KALRN BAZ2B	9.47e-05	552	40	7	int:COIL
Interaction	SMC5 interactions	EIF5A HTATSF1 SMARCC2 EIF5AL1 PARP1 CHD7 TRIP12 BAZ2B SMC6	1.20e-04	1000	40	9	int:SMC5
Interaction	MYB interactions	KDM2B PARP1 ZFHX3 CHD7	1.38e-04	133	40	4	int:MYB
Interaction	SH3GL3 interactions	EIF5A EIF5AL1 PARP1 AKAP12	1.92e-04	145	40	4	int:SH3GL3
Interaction	REST interactions	HTATSF1 SMARCC2 PARP1 HDAC5 PPID	2.00e-04	274	40	5	int:REST
Interaction	DSCR9 interactions	TRIO KALRN TRIP12 PBXIP1	2.02e-04	147	40	4	int:DSCR9
GeneFamily	Zinc fingers CXXC-type	KDM2B FBXL19 TET3	6.48e-07	12	27	3	136
GeneFamily	PHD finger proteins	KDM2B FBXL19 BAZ2B	3.20e-04	90	27	3	88
GeneFamily	F-box and leucine rich repeat proteins	KDM2B FBXL19	4.43e-04	21	27	2	558
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	SMARCC2 CHD7	2.82e-03	53	27	2	532
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO KALRN	4.34e-03	66	27	2	722
GeneFamily	Ring finger proteins	RNF213 TRIM44 LTN1	7.77e-03	275	27	3	58
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TRIO KALRN	2.39e-02	161	27	2	593
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RNF213 CHD7 TRIO BAZ2B PCNT	9.57e-07	200	40	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Disease	colorectal cancer (is_marker_for)	EIF5A ZFHX3 AMER1 HDAC5	5.49e-05	157	39	4	DOID:9256 (is_marker_for)
Disease	Moyamoya Disease	RNF213 PCNT	2.29e-04	17	39	2	C0026654
Disease	nevus count, cutaneous melanoma	PARP1 AKAP12 TMCC2	2.39e-04	91	39	3	EFO_0000389, EFO_0004632
Disease	Dysphagia	BAZ2B TTC23L	4.61e-04	24	39	2	HP_0002015
Disease	cutaneous melanoma	PARP1 AKAP12 TMCC2	5.52e-04	121	39	3	EFO_0000389
Disease	unipolar depression	EIF5A RNF213 EIF5AL1 ZFHX3 CHD7 TRIO TRIM44	9.14e-04	1206	39	7	EFO_0003761
Disease	stroke	FGB ZFHX3 KALRN	9.15e-04	144	39	3	EFO_0000712
Disease	Obesity	PARP1 ZFHX3 ACACB	2.51e-03	205	39	3	C0028754

Protein segments in the cluster

Peptide	Gene	Start	Entry
QEKGELDELGDKCDS	ALX1	111	Q15699
AESGQAVEECKEEGE	AKAP12	256	Q02952
EVALKGEGTEEAECK	AKAP12	1301	Q02952
GEGTEEAECKKDDAL	AKAP12	1306	Q02952
GKKTDICEDEDEGDQ	BAZ2B	1326	Q9UIF8
CEVEEGDKPDVDKAV	ALDH1A3	61	P47895
IADVERDGEGKCEEN	AMER1	811	Q5JTC6
KCEGKEEEEETDGSG	CHD7	2186	Q9P2D1
CGEAGKEDTVEGEEE	FBXL19	91	Q6PCT2
GKRKGDEVDGVDEVA	PARP1	206	P09874
ENEKCVSSEGEKIEG	LTN1	551	O94822
EDVYDKGCVKDVDEG	ACACB	426	O00763
KGCVKDVDEGLEAAE	ACACB	431	O00763
GEGETETQGKGEECE	SLC24A1	781	O60721
GLGKKEEGEEEKGEE	CFAP65	1756	Q6ZU64
LGECGKVAEDKEESE	LMOD2	86	Q6P5Q4
VSGKECEEIIRKGGE	FGB	236	P02675
GEKGADSGEEKEEGI	PBDC1	191	Q9BVG4
CCEEGKGELKDGLEV	KALRN	1431	O60229
EGDLGKEIEQKYDCG	EIF5A	116	P63241
EDGGKGKEKVLEDCQ	PCNT	2046	O95613
KEAEEGCPEKESEEG	HTATSF1	456	O43719
EGDLGKEIEQKYDCG	EIF5AL1	116	Q6IS14
GEAGKEDTVEEEEGK	KDM2B	666	Q8NHM5
FVKGLGEVDCKEIGD	ARFGEF3	1361	Q5TH69
CIQVKDEEGESGAEE	HDAC5	601	Q9UQL6
ADGEGAGKEEAEVKV	TRIM44	71	Q96DX7
EEAEGIGDKVDKGDL	TMCC2	241	O75069
CVIAECGELKEGDDG	PPID	176	Q08752
REGGGAIEEEAKEKT	SMARCC2	776	Q8TAQ2
KEGIVECNGGVAEED	EIF4ENIF1	261	Q9NRA8
EGEMECGQELKEEGG	RNF213	46	Q63HN8
ESEGEAKEGKSEREG	TCEAL4	66	Q96EI5
GVCKEEIGTEDEKGD	TIGD3	406	Q6B0B8
EETEVKGTLEGDVCG	PBXIP1	76	Q96AQ6
AGAEAEAEEVKTGKC	TSPYL1	146	Q9H0U9
FDKDGDEDECKGTTL	SMC6	26	Q96SB8
AVKEEKGGGGAEEEE	TET3	1621	O43151
TGGCGESEEETKAKE	TTC23L	41	Q6PF05
VREDEESNKDCVGGK	TRIP12	1401	Q14669
EKREDGGAGSTEKVE	ZMYND15	126	Q9H091
TCCEEGKGEIKDGLE	TRIO	1441	O75962
GEKQEVGDGDCFSEK	ZFHX3	441	Q15911