Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9	1.12e-08	37	86	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9	1.32e-08	38	86	6	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7	1.24e-05	11	86	3	GO:0004523
GeneOntologyMolecularFunction	ABC-type sterol transporter activity	ABCG4 ABCG1	1.83e-05	2	86	2	GO:0034041
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	2.71e-05	14	86	3	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7	9.70e-05	21	86	3	GO:0035613
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 XRN1 ERVK-7 CNOT1	3.05e-04	136	86	5	GO:0004540
GeneOntologyMolecularFunction	vasopressin receptor activity	AVPR1A AVPR1B	3.80e-04	7	86	2	GO:0005000
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 PDE2A ENPP1 KAT6A ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ZZEF1 NR1I3 PML	4.23e-04	891	86	12	GO:0008270
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ENPP1 ERVK-8 XRN1 ERVK-7 CNOT1	4.88e-04	231	86	6	GO:0004518
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	5.39e-04	37	86	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	5.84e-04	38	86	3	GO:0034061
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCG4 ABCG1	6.47e-04	9	86	2	GO:0034040
GeneOntologyMolecularFunction	angiotensin receptor binding	ZBTB16 ARRB2	8.07e-04	10	86	2	GO:0031701
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	1.02e-03	46	86	3	GO:0016893
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 GGT6 TMPRSS11E USP24 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9	2.00e-03	654	86	9	GO:0008233
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7	1.87e-05	13	85	3	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 XRN1 ERVK-7 PML	2.38e-05	83	85	5	GO:0006278
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.67e-05	85	85	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.67e-05	85	85	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	3.34e-05	89	85	5	GO:0006949
GeneOntologyBiologicalProcess	cellular response to high density lipoprotein particle stimulus	ABCG4 ABCG1	1.00e-04	4	85	2	GO:0071403
GeneOntologyBiologicalProcess	viral process	ERVK-6 AVPR1B TMPRSS11E ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 FUT8	1.24e-04	464	85	9	GO:0016032
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by vasopressin	AVPR1A AVPR1B	1.66e-04	5	85	2	GO:0001992
GeneOntologyBiologicalProcess	peptidyl-tryptophan modification	DPY19L2 DPY19L1	2.49e-04	6	85	2	GO:0018211
GeneOntologyBiologicalProcess	protein C-linked glycosylation via tryptophan	DPY19L2 DPY19L1	2.49e-04	6	85	2	GO:0018317
GeneOntologyBiologicalProcess	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	DPY19L2 DPY19L1	2.49e-04	6	85	2	GO:0018406
GeneOntologyBiologicalProcess	protein C-linked glycosylation	DPY19L2 DPY19L1	2.49e-04	6	85	2	GO:0018103
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-6 ARRB2 ERVK-8 XRN1 ERVK-7 PML	2.84e-04	218	85	6	GO:0071897
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.62e-05	12	80	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.62e-05	12	80	3	IPR027970
Domain	ABCG1	ABCG4 ABCG1	1.81e-05	2	80	2	IPR020064
Domain	DUF1856	AVPR1A AVPR1B	1.81e-05	2	80	2	IPR015076
Domain	DUF1856	AVPR1A AVPR1B	1.81e-05	2	80	2	SM01164
Domain	DUF1856	AVPR1A AVPR1B	1.81e-05	2	80	2	PF08983
Domain	Dpy19	DPY19L2 DPY19L1	1.08e-04	4	80	2	PF10034
Domain	Dpy-19/Dpy-19-like	DPY19L2 DPY19L1	1.08e-04	4	80	2	IPR018732
Domain	ABC_2_trans	ABCG4 ABCG1	1.80e-04	5	80	2	IPR013525
Domain	Vasoprsn_rcpt	AVPR1A AVPR1B	1.80e-04	5	80	2	IPR001817
Domain	ABC2_membrane	ABCG4 ABCG1	1.80e-04	5	80	2	PF01061
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	CAMK1D NIM1K ULK2	3.24e-03	69	80	3	IPR020636
Domain	ARM-type_fold	STAG1 DOCK8 USP24 NBEA ZYG11B CTNND2	3.33e-03	339	80	6	IPR016024
Domain	Spectrin	TRIO MACF1	4.32e-03	23	80	2	PF00435
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	7.22e-11	12	88	5	14557543
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	1.91e-10	5	88	4	12629516
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	5.72e-10	6	88	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	5.72e-10	6	88	4	25930072
Pubmed	Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance.	ARRB2 AVPR1A AVPR1B	6.25e-08	4	88	3	29713080
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9	1.50e-07	94	88	6	21542922
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	3.11e-07	6	88	3	15063128
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	3.91e-07	24	88	4	32212159
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.85e-06	10	88	3	12970426
Pubmed	Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.	ABCG4 ABCG1	6.33e-06	2	88	2	15240127
Pubmed	V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze.	AVPR1A AVPR1B	6.33e-06	2	88	2	15036628
Pubmed	The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors.	AVPR1A AVPR1B	6.33e-06	2	88	2	17049983
Pubmed	Functional Cooperativity between ABCG4 and ABCG1 Isoforms.	ABCG4 ABCG1	6.33e-06	2	88	2	27228027
Pubmed	Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag.	AVPR1A AVPR1B	6.33e-06	2	88	2	24092737
Pubmed	[Arginine-vasopressin receptor gene (AVPR1A, AVPR1B) polymorphisms and their relation to personality traits].	AVPR1A AVPR1B	6.33e-06	2	88	2	25438555
Pubmed	Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury.	AVPR1A AVPR1B	6.33e-06	2	88	2	27713143
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	6.33e-06	2	88	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	6.33e-06	2	88	2	9460924
Pubmed	Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein.	ERVK-6 ZBTB16	6.33e-06	2	88	2	10980608
Pubmed	Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.	ZBTB16 PML	6.33e-06	2	88	2	9294197
Pubmed	Both V(1A) and V(1B) vasopressin receptors deficiency result in impaired glucose tolerance.	AVPR1A AVPR1B	6.33e-06	2	88	2	19375419
Pubmed	Modulation of male mouse sociosexual and anxiety-like behaviors by vasopressin receptors.	AVPR1A AVPR1B	6.33e-06	2	88	2	30290180
Pubmed	Tissue and zonal-specific expression of an olfactory receptor transgene.	OR10H3 OR10H4	6.33e-06	2	88	2	9412503
Pubmed	LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL.	ABCG4 ABCG1	6.33e-06	2	88	2	16556852
Pubmed	Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice.	AVPR1A AVPR1B	6.33e-06	2	88	2	19693000
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.	ABCG4 ABCG1	6.33e-06	2	88	2	18039927
Pubmed	Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.	AVPR1A AVPR1B	6.33e-06	2	88	2	9357056
Pubmed	Structure and sequence of the mouse V1a and V1b vasopressin receptor genes.	AVPR1A AVPR1B	6.33e-06	2	88	2	10669045
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF462 POGZ RAD54L2 KAT14 PML	1.71e-05	125	88	5	32891193
Pubmed	The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.	AVPR1A AVPR1B	1.90e-05	3	88	2	9322919
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	1.90e-05	3	88	2	10516026
Pubmed	Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.	ZBTB16 PML	1.90e-05	3	88	2	19523849
Pubmed	ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane.	ABCG4 ABCG1	1.90e-05	3	88	2	25302608
Pubmed	Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor.	AVPR1A AVPR1B	1.90e-05	3	88	2	33320834
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	1.90e-05	3	88	2	9971820
Pubmed	ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.	ABCG4 ABCG1	1.90e-05	3	88	2	27196068
Pubmed	Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.	PRMT6 PML	1.90e-05	3	88	2	22904064
Pubmed	C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.	FOXM1 NR1I3	1.90e-05	3	88	2	18798339
Pubmed	ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.	ABCG4 ABCG1	1.90e-05	3	88	2	16902247
Pubmed	The bilevel chamber revealed differential involvement of vasopressin and oxytocin receptors in female mouse sexual behavior.	AVPR1A AVPR1B	1.90e-05	3	88	2	38900750
Pubmed	Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF.	ZBTB16 PML	1.90e-05	3	88	2	11175338
Pubmed	ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.	ABCG4 ABCG1	1.90e-05	3	88	2	17916878
Pubmed	MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R.	AVPR1A AVPR1B	1.90e-05	3	88	2	10477084
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF462 ABCG1 SGSM1 ZBTB16 ARRB2 TRIO ARHGAP44 KAT6A OSBPL5 MACF1 PLA2G6 XRCC2 CNOT1 INVS	2.16e-05	1489	88	14	28611215
Pubmed	Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.	AVPR1A AVPR1B	3.79e-05	4	88	2	9581826
Pubmed	Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor.	AVPR1A AVPR1B	3.79e-05	4	88	2	11955056
Pubmed	The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.	ABCG4 ABCG1	3.79e-05	4	88	2	31159502
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7	3.79e-05	4	88	2	10469592
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins.	ABCG4 ABCG1	3.79e-05	4	88	2	15210959
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	3.79e-05	4	88	2	7983737
Pubmed	Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.	RAD54L2 DCAF7	3.79e-05	4	88	2	26412716
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	PDE2A TRIO MACF1 DGKZ NBEA CTNND2	4.40e-05	251	88	6	27507650
Pubmed	Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice.	AVPR1A AVPR1B	6.30e-05	5	88	2	35017259
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	6.30e-05	5	88	2	11401426
Pubmed	Expression and functional characterization of ABCG1 splice variant ABCG1(666).	ABCG4 ABCG1	6.30e-05	5	88	2	16870176
Pubmed	Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues.	AVPR1A AVPR1B	6.30e-05	5	88	2	29231812
Pubmed	Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation.	FOXM1 NR1I3	6.30e-05	5	88	2	21705713
Pubmed	Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling.	AVPR1A AVPR1B	6.30e-05	5	88	2	26903624
Pubmed	Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.	AVPR1A AVPR1B	6.30e-05	5	88	2	12486173
Pubmed	Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.	ABCG4 ABCG1	6.30e-05	5	88	2	23584088
Pubmed	Molecular pharmacology and modeling of vasopressin receptors.	AVPR1A AVPR1B	6.30e-05	5	88	2	12436935
Pubmed	MOZ increases p53 acetylation and premature senescence through its complex formation with PML.	KAT6A PML	9.43e-05	6	88	2	23431171
Pubmed	[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia].	ZBTB16 PML	9.43e-05	6	88	2	15968309
Pubmed	Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.	AVPR1A AVPR1B	9.43e-05	6	88	2	18384079
Pubmed	DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers.	RAD54L2 DCAF7	9.43e-05	6	88	2	30137413
Pubmed	Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation.	AVPR1A AVPR1B	9.43e-05	6	88	2	10858434
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PDE2A CORO2B STAG1 TRIO MACF1 NBEA POGZ RAD54L2 CTNND2 FUT8 ZNF583 SEZ6L	9.46e-05	1285	88	12	35914814
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF462 ARRB2 USP24 XRN1 POGZ CNOT1 KAT14	9.47e-05	418	88	7	34709266
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PDE2A TRIO KIF26A ARHGAP44 KAT6A OSBPL5 CPSF1 PLA2G6 ZZEF1 ULK2 ARHGAP33	1.09e-04	1105	88	11	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DCDC1 KAT6A XRN1 MACF1 POGZ ZZEF1 KAT14 ARHGAP33 SEZ6L PML DCAF7	1.18e-04	1116	88	11	31753913
Pubmed	Physical and functional link of the leukemia-associated factors AML1 and PML.	KAT6A PML	1.32e-04	7	88	2	15331439
Pubmed	CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.	NR1I3 PML	1.32e-04	7	88	2	26407237
Pubmed	Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.	AVPR1A AVPR1B	1.32e-04	7	88	2	34077719
Pubmed	An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.	AVPR1A AVPR1B	1.32e-04	7	88	2	37844254
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ZNF462 PDE2A TRIO ARHGAP44 MACF1 DGKZ NBEA CTNND2 CNOT1 DCAF7	1.62e-04	963	88	10	28671696
Pubmed	K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR.	RAD54L2 DCAF7	1.75e-04	8	88	2	34117217
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZNF462 POGZ RAD54L2 KAT14 PML	2.58e-04	222	88	5	37071664
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	XRN1 RAD54L2 CNOT1 DCAF7	2.68e-04	122	88	4	30773093
Pubmed	Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.	AVPR1A AVPR1B	2.81e-04	10	88	2	20368512
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ZNF462 TRIO XRN1 CPSF1 PLA2G6 PML DCAF7	3.31e-04	513	88	7	25798074
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	MACF1 CTNND2	3.43e-04	11	88	2	39256359
Pubmed	TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.	RAD54L2 PML	3.43e-04	11	88	2	35061896
Pubmed	NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.	XRN1 CNOT1	4.85e-04	13	88	2	20133598
Pubmed	Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase Cɛ-dependent sumoylation.	ZBTB16 NDN	4.85e-04	13	88	2	25178676
Pubmed	Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.	AVPR1A AVPR1B	4.85e-04	13	88	2	26531127
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZNF462 POGZ CNOT1 DCAF7	5.29e-04	146	88	4	23892456
Pubmed	Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.	XRN1 CNOT1	5.65e-04	14	88	2	20584987
Pubmed	Functional consequences of necdin nucleocytoplasmic localization.	MYL9 NDN POGZ	5.83e-04	64	88	3	22442722
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	ZNF462 ANO2	7.42e-04	16	88	2	16096065
Pubmed	Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.	MYL9 INVS	7.42e-04	16	88	2	32460029
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	OR10H3 OR10H4	7.42e-04	16	88	2	17521568
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	TRIO MACF1 DGKZ NBEA CTNND2	7.53e-04	281	88	5	28706196
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZBTB16 ARRB2 STAG1 DOCK8 MACF1 ZZEF1 INVS	7.64e-04	591	88	7	15231748
Pubmed	An investigation into the human serum "interactome".	TGM4 SPATA31A7 MACF1 CNOT1	7.80e-04	162	88	4	15174051
Pubmed	A method to identify cDNAs based on localization of green fluorescent protein fusion products.	KAT6A PML	8.40e-04	17	88	2	10716735
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9	9.43e-04	18	88	2	18664271
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDE2A CORO2B TRIO DOCK8 ARHGAP44 XRN1 MACF1 DGKZ NBEA CTNND2 CNOT1	9.66e-04	1431	88	11	37142655
Pubmed	Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.	DPY19L2 DPY19L1	1.17e-03	20	88	2	22028030
Pubmed	A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.	ZNF462 TRIO	1.29e-03	21	88	2	24025145
Pubmed	E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.	FOXM1 PML	1.41e-03	22	88	2	35792897
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	9.87e-05	8	87	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	9.54e-04	24	87	2	9p13.1
Cytoband	5p15.2	TRIO CTNND2	1.21e-03	27	87	2	5p15.2
Cytoband	12p13.3	ANO2 CD163L1	1.49e-03	30	87	2	12p13.3
GeneFamily	Arginine vasopressin and oxytocin receptors	AVPR1A AVPR1B	6.69e-05	4	61	2	259
GeneFamily	Blood group antigens\|CD molecules\|ATP binding cassette subfamily G	ABCG4 ABCG1	1.11e-04	5	61	2	811
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO ZBTB16 CAMK1D MYL9 CINP	7.79e-06	149	81	5	defe2e4a2f3118f8b42e99a4f2bf03e54c1b698f
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P1-P1_2\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FOXM1 TGM4 KCNJ13 SPOCD1	1.07e-05	75	81	4	9a82db6281326acc534b800e02b262a8617a147e
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocyte.Tnr.Pdgfa_(Pdgfa)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FOXM1 TGM4 KCNJ13 SPOCD1	1.07e-05	75	81	4	7678e7d514560c774b56fc0a20312d561c89f587
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FOXM1 TGM4 KCNJ13 SPOCD1	1.07e-05	75	81	4	7f1fc575fca42352434f7188c7a95b50372aeefa
Drug	Vasopressin	AVPR1A AVPR1B	3.56e-05	3	79	2	DB00067
Drug	Terlipressin	AVPR1A AVPR1B	3.56e-05	3	79	2	DB02638
Drug	Desmopressin	AVPR1A AVPR1B	3.56e-05	3	79	2	DB00035
Drug	Mtpia-oxytocin	AVPR1A AVPR1B	3.56e-05	3	79	2	CID003083145
Drug	NSC342736	MPO ERVK-6	3.56e-05	3	79	2	CID000433641
Drug	Haloperidol [52-86-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	POGZ XRCC2 RAD54L2 ULK2 ARHGAP33 PML	5.71e-05	193	79	6	5273_DN
Drug	ST021200; Up 200; 10uM; PC3; HT_HG-U133A	TRIO AVPR1B KAZN ULK2 ITIH2 PML	5.87e-05	194	79	6	7493_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Up 200; 7.2uM; MCF7; HT_HG-U133A	TGM4 CORO2B TRIO XRCC2 ZZEF1 NR1I3	6.04e-05	195	79	6	4148_UP
Drug	Hymecromone [90-33-5]; Up 200; 22.8uM; MCF7; HT_HG-U133A	KAT6A CPSF1 PLA2G6 ZZEF1 ITIH2 NR1I3	6.22e-05	196	79	6	3383_UP
Drug	Fluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; HL60; HT_HG-U133A	ABCG4 ANO2 PDE2A ABCG1 ARHGAP44 KAT6A	6.22e-05	196	79	6	2913_UP
Drug	Merbromin [129-16-8]; Up 200; 5uM; PC3; HT_HG-U133A	CORO2B TRIO NDN CTNND2 ZZEF1 INVS	6.22e-05	196	79	6	3700_UP
Drug	Oxalamine citrate salt [1949-20-8]; Up 200; 9.2uM; HL60; HT_HG-U133A	CORO2B TRIO ENPP1 NR1I3 ARHGAP33 SEZ6L	6.22e-05	196	79	6	3006_UP
Drug	benserazide hydrochloride; Down 200; 10uM; SKMEL5; HG-U133A	ARRB2 TRIO PLA2G6 ZZEF1 ARHGAP33 PML	6.22e-05	196	79	6	631_DN
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A	TRIO XRCC2 RAD54L2 ULK2 ARHGAP33 PML	6.22e-05	196	79	6	2249_DN
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; PC3; HT_HG-U133A	ABCG1 MYL9 POGZ CTNND2 SEZ6L PML	6.40e-05	197	79	6	5751_UP
Drug	Sulfamethizole [144-82-1]; Up 200; 14.8uM; PC3; HT_HG-U133A	CORO2B CAMK1D TRIO PLA2G6 NDN PML	6.40e-05	197	79	6	5798_UP
Drug	Catechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; PC3; HT_HG-U133A	MPO CORO2B KCNJ13 KAT6A ITIH2 PML	6.76e-05	199	79	6	4255_UP
Drug	Paromomycin sulfate [1263-89-4]; Up 200; 5.6uM; PC3; HT_HG-U133A	ABCG1 CORO2B ARHGAP44 PLA2G6 CTNND2 PML	6.76e-05	199	79	6	4595_UP
Drug	2,2',4,6-tetrachlorobiphenyl	PLA2G6 NR1I3	7.10e-05	4	79	2	ctd:C447028
Drug	Ac-VP	AVPR1A AVPR1B	7.10e-05	4	79	2	CID000149364
Drug	D-Mlvp	AVPR1A AVPR1B	7.10e-05	4	79	2	CID003083074
Disease	Intellectual Disability	ZNF462 STAG1 TRIO DOCK8 BCKDK MACF1 NBEA POGZ FUT8	2.01e-06	447	75	9	C3714756
Disease	portal hypertension (is_marker_for)	ARRB2 AVPR1A	9.50e-05	6	75	2	DOID:10762 (is_marker_for)
Disease	acute promyelocytic leukemia (is_implicated_in)	ZBTB16 PML	1.33e-04	7	75	2	DOID:0060318 (is_implicated_in)
Disease	Precancerous Conditions	FOXM1 MPO TRIO NR1I3	1.81e-04	110	75	4	C0032927
Disease	Condition, Preneoplastic	FOXM1 MPO TRIO NR1I3	1.81e-04	110	75	4	C0282313
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	PRMT6 STAG1 NIM1K MACF1 PLA2G6 ZZEF1	3.33e-04	364	75	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	autism spectrum disorder (implicated_via_orthology)	BCKDK NBEA POGZ CTNND2	6.19e-04	152	75	4	DOID:0060041 (implicated_via_orthology)
Disease	nevus count	DOCK8 PLA2G6	9.50e-04	18	75	2	EFO_0004632
Disease	renovascular hypertension (biomarker_via_orthology)	MPO AVPR1A	1.06e-03	19	75	2	DOID:1591 (biomarker_via_orthology)
Disease	response to antidepressant	ENPP1 CCR3 XRCC2 CTNND2	1.07e-03	176	75	4	GO_0036276
Disease	cardiovascular system disease (is_implicated_in)	MPO ENPP1	1.30e-03	21	75	2	DOID:1287 (is_implicated_in)
Disease	migraine disorder, Headache	ZNF462 CAMK1D DGKZ	1.39e-03	86	75	3	HP_0002315, MONDO_0005277
Disease	body fat percentage	PRMT6 STAG1 NIM1K MACF1 PLA2G6 ZZEF1	1.52e-03	488	75	6	EFO_0007800
Disease	IGF-1 measurement	ZNF462 STAG1 AVPR1A TMPRSS11E DGKZ ULK2	1.52e-03	488	75	6	EFO_0004627
Disease	Neurodevelopmental Disorders	TRIO DOCK8 POGZ	1.74e-03	93	75	3	C1535926
Disease	acute kidney failure (implicated_via_orthology)	MPO AVPR1A	2.15e-03	27	75	2	DOID:3021 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRDTVLTHLRFMSHV	ABCG4	386	Q9H172
IMRDSVLTHLRITSH	ABCG1	416	P45844
VRLMRYRSHVLHSLL	RAD54L2	541	Q9Y4B4
VSLEARLSRMHFHDS	ANO2	81	Q9NQ90
REPHFTERTLHILMS	CD163L1	741	Q9NR16
SRLGIRMLATHHLAL	BCKDK	196	O14874
LLVDLLDHRMTEVHR	CTNND2	596	Q9UQB3
VRMFDLRHLEHSTII	DCAF7	201	P61962
ETTRHFLMSDRSLHL	ARRB2	186	P32121
EELIRTLLGAHTRHM	NR1I3	111	Q14994
FVLLDMVHSLLHRLS	CT47A1	121	Q5JQC4
SALRFQAMEETHLRH	FCHO1	196	O14526
EILDSHVRAHLRMKA	DCDC1	1096	M0R2J8
ILRRHLAEEMSAVFH	KAZN	666	Q674X7
RRITRSILQMSLDHH	ITIH2	606	P19823
LSHSLEAEHRLLKAM	GPBP1L1	381	Q9HC44
TMLSHSFLEDVIRRL	FSIP2	4136	Q5CZC0
RHGFLILSREDSTMI	CPSF1	571	Q10570
GFIHEDHLRELLTTM	MYL9	116	P24844
LQQMSERFLHHTRTL	KXD1	56	Q9BQD3
ERFLHHTRTLVEMKR	KXD1	61	Q9BQD3
MRDIILATDLAHHLR	PDE2A	761	O00408
ELTSMHTLLLREHNR	MPO	411	P05164
MDSSIHLSSLISRHD	KAT14	1	Q9H8E8
RHFSHLSTLEREMAF	DPY19L1	46	Q2PZI1
SEIMLHHCFASLLTR	KCNJ13	291	O60928
EDARRSSHMLFTLHV	KIF26A	596	Q9ULI4
LLMLHRARITDVEHI	ENPP1	881	P22413
DRHFSHLSSLEREMT	DPY19L2	131	Q6NUT2
RLLSREISSMEKLHH	NIM1K	116	Q8IY84
IIRHKDSMDELFSHR	MACF1	5721	Q9UPN3
RMLADLLFTHRSITF	OR10H3	81	O60404
RMLADLLSTHHSITF	OR10H4	81	Q8NGA5
DITSTLHHLRMLDFR	KAT6A	726	Q92794
LHHLRMLDFRSDQFV	KAT6A	731	Q92794
EYLLRHLARMARHSA	ARHGAP33	441	O14559
YMRTLLDSIAHGHRL	ERVK-19	331	Q9YNA8
YMRTLLDSIAHGHRL	ERVK-21	331	P62683
YMRTLLDSIAHGHRL	ERVK-6	331	Q7LDI9
YMRTLLDSIAHGHRL	ERVK-7	331	P63130
YMRTLLDSIAHGHRL	ERVK-8	331	P62685
YMRTLLDSIAHGHRL	ERVK-9	331	P63126
YMRTLLDSIAHGHRL	HERVK_113	331	P62684
MTEALLELHGHSRRV	CORO2B	126	Q9UQ03
SMRLEFLRILCSHEH	DOCK8	1091	Q8NF50
RHFHTLRMTIFCLVL	CCR3	196	P51677
VARAMTHTLLRHLAA	GGT6	426	Q6P531
LLHESMLSSVLHART	PRMT6	161	Q96LA8
HTSRSVRHFLDLFME	DENND2C	856	Q68D51
LDAVMSRLPHHSESR	MARVELD2	486	Q8N4S9
RHNLSLHDMFVRETS	FOXM1	286	Q08050
LMHRDEQSRTLLHHA	DGKZ	816	Q13574
FLLSHLSLMDILHVS	OR2AJ1	61	Q8NGZ0
DLEEMTPLHLTTRHR	INVS	111	Q9Y283
ELHRHLSAMLSSTAR	OSBPL5	831	Q9H0X9
CSISHLHSLFRVLLM	OR1L6	186	Q8NGR2
EFLLDLGHHERSIMT	FUT8	151	Q9BYC5
ERLLLHDKDRMTVHS	SEZ6L	496	Q9BYH1
HNVSFMELLSAHRRD	PML	801	P29590
DVHFRMIHEDTRHLL	POGZ	606	Q7Z3K3
HTHSLFTLLGERLML	NBEA	786	Q8NFP9
ELHDLMAARRSKLVH	SPATA31A7	1071	Q8IWB4
MDHAFLLLSSEREHR	TGM4	451	P49221
ILGSMRDEKRTHDHL	PLA2G6	466	O60733
DLRLHEGTMRTTSHR	TEX45	31	Q8NA69
RLSPLEHMRRHSVTD	ARHGAP44	791	Q17R89
VRHMRKLHLGSSLDS	CAMK1D	316	Q8IU85
YMRTLLDSIAHGHRL	ERVK-9	331	P63128
SRLHLESMLLETGHR	CINP	196	Q9BW66
LISHRIFIARMLAHT	CNOT1	2041	A5YKK6
ELHDLMAARRSKLVH	SPATA31A3	1071	Q5VYP0
LAHMLLICRFHSTED	TMPRSS11E	116	Q9UL52
VREALFHLFSLTHVM	ZYG11B	341	Q9C0D3
RSRMHLFVLHLALTD	AVPR1B	66	P47901
FLDSLRLRMHLLAHS	ZBTB16	441	Q05516
ELHDLMAARRSKLVH	SPATA31A1	1071	Q5TZJ5
ELHDLMAARRSKLVH	SPATA31A5	1071	Q5VU36
HQALLRHLESLATMS	SPOCD1	1146	Q6ZMY3
MLGLTSHEAHFSLLR	XRN1	211	Q8IZH2
PEETTFHLLHLSLMR	XRN1	241	Q8IZH2
FISLVSIRRHMLTHR	ZNF627	176	Q7L945
RDMGITLHLLLHSDR	SCFD1	66	Q8WVM8
RMLVLFFLESELHEH	STAG1	466	Q8WVM7
SHLHRMLHRDSTISN	SGSM1	691	Q2NKQ1
MHLFIRHLSLADLAV	AVPR1A	86	P37288
HFDMLRLVTILEHRL	XRCC2	86	O43543
ETLMEREHTDTLRHL	ULK2	816	Q8IYT8
DLLLRHSALRHMISF	USP24	2301	Q9UPU5
IHSSMILRFLHRNRL	ZZEF1	181	O43149
LRSHERSHLALAMFT	ZNF462	2006	Q96JM2
MERREHLTLTFHSPE	TMEM202	1	A6NGA9
AHHERIHTMESFLTL	ZNF583	536	Q96ND8
VSTMLDRLHSTRQHL	TRIO	311	O75962
FGLHLRLTSLHTMEF	NDN	151	Q99608