Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9	2.39e-06	152	51	6	GO:0022843
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCND2 KCND3 ABCC8 KCNQ1 ABCC9	6.14e-06	102	51	5	GO:0005249
GeneOntologyMolecularFunction	sulfonylurea receptor activity	ABCC8 ABCC9	6.40e-06	2	51	2	GO:0008281
GeneOntologyMolecularFunction	dopamine neurotransmitter receptor activity, coupled via Gs	DRD1 DRD5	6.40e-06	2	51	2	GO:0001588
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9	6.76e-06	182	51	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9	7.20e-06	184	51	6	GO:0022832
GeneOntologyMolecularFunction	potassium channel activity	KCND2 KCND3 ABCC8 KCNQ1 ABCC9	1.86e-05	128	51	5	GO:0005267
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	1.96e-05	459	51	8	GO:0005216
GeneOntologyMolecularFunction	gated channel activity	CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	2.12e-05	334	51	7	GO:0022836
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9 SLC1A6	2.15e-05	465	51	8	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9	2.51e-05	343	51	7	GO:0005261
GeneOntologyMolecularFunction	A-type (transient outward) potassium channel activity	KCND2 KCND3	3.82e-05	4	51	2	GO:0005250
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCND2 KCND3 KCNQ1	4.40e-05	27	51	3	GO:0015271
GeneOntologyMolecularFunction	channel activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	5.10e-05	525	51	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	5.17e-05	526	51	8	GO:0022803
GeneOntologyMolecularFunction	dopamine neurotransmitter receptor activity	DRD1 DRD5	6.36e-05	5	51	2	GO:0004952
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCND2 KCND3 ABCC8 KCNQ1 ABCC9	6.63e-05	167	51	5	GO:0015079
GeneOntologyMolecularFunction	transmembrane transporter binding	CACNA1C KCND3 ABCC8 KCNQ1 ABCC9	7.63e-05	172	51	5	GO:0044325
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CACNA1C KCND2	9.53e-05	6	51	2	GO:1905030
GeneOntologyMolecularFunction	ATP-activated inward rectifier potassium channel activity	ABCC8 ABCC9	9.53e-05	6	51	2	GO:0015272
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 SLC1A6	1.13e-04	758	51	9	GO:0015318
GeneOntologyMolecularFunction	dopamine binding	DRD1 DRD5	1.33e-04	7	51	2	GO:0035240
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 SLC1A6	1.60e-04	793	51	9	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9 SLC1A6	1.75e-04	627	51	8	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9 SLC1A6	2.58e-04	664	51	8	GO:0008324
GeneOntologyMolecularFunction	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	KCND3 KCNQ1	4.15e-04	12	51	2	GO:1902282
GeneOntologyMolecularFunction	catecholamine binding	DRD1 DRD5	4.90e-04	13	51	2	GO:1901338
GeneOntologyMolecularFunction	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	KCND3 KCNQ1	6.57e-04	15	51	2	GO:0086008
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	DRD1 DRD5 GLRB	9.31e-04	75	51	3	GO:0098960
GeneOntologyMolecularFunction	transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB PITPNM3 KCNQ1 ABCC9 SLC1A6	1.36e-03	1289	51	10	GO:0005215
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	DRD1 DRD5 ABCC8 GLRB MC2R OR1L6 ABCC9 LPAR2 TAS2R38 FZD2	1.96e-03	1353	51	10	GO:0004888
GeneOntologyMolecularFunction	neurotransmitter receptor activity	DRD1 DRD5 GLRB	2.13e-03	100	51	3	GO:0030594
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	ABCC8 ABCC9	2.32e-03	28	51	2	GO:0005242
GeneOntologyMolecularFunction	transmembrane transporter activity	TRPM6 CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 SLC1A6	2.74e-03	1180	51	9	GO:0022857
GeneOntologyMolecularFunction	calmodulin binding	CACNA1C MYO5B KCNQ1 ADCY1	2.80e-03	230	51	4	GO:0005516
GeneOntologyMolecularFunction	PDZ domain binding	LPAR2 FZD2 NOS1AP	3.83e-03	123	51	3	GO:0030165
GeneOntologyMolecularFunction	G-protein alpha-subunit binding	DRD1 DRD5	5.40e-03	43	51	2	GO:0001965
GeneOntologyMolecularFunction	protein domain specific binding	CACNA1C SNAP91 LPAR2 APP FZD2 NOS1AP KLHL17	6.53e-03	875	51	7	GO:0019904
GeneOntologyMolecularFunction	G protein-coupled receptor activity	DRD1 DRD5 MC2R OR1L6 LPAR2 TAS2R38 FZD2	6.89e-03	884	51	7	GO:0004930
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC8 ABCC9	6.97e-03	49	51	2	GO:0140359
GeneOntologyBiologicalProcess	action potential	CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 ABCC9 NOS1AP	3.15e-08	201	51	8	GO:0001508
GeneOntologyBiologicalProcess	regulation of membrane potential	CACNA1C DRD1 KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 APP SLC1A6 NOS1AP	9.37e-08	559	51	11	GO:0042391
GeneOntologyBiologicalProcess	behavior	HEXB CACNA1C DRD1 DRD5 KCND2 ABCC8 GLRB KCNQ1 UBR3 BCHE APP ADCY1 RNF170	1.73e-07	891	51	13	GO:0007610
GeneOntologyBiologicalProcess	regulation of blood circulation	CACNA1C DRD1 KCND2 KCND3 KCNQ1 ABCC9 APP NOS1AP	1.26e-06	326	51	8	GO:1903522
GeneOntologyBiologicalProcess	neuromuscular process	HEXB DRD1 BLOC1S4 ABCC8 GLRB APP RNF170	1.29e-06	225	51	7	GO:0050905
GeneOntologyBiologicalProcess	visual learning	CACNA1C DRD1 DRD5 ABCC8 APP	1.39e-06	78	51	5	GO:0008542
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell action potential	CACNA1C KCND3 KCNQ1 NOS1AP	2.06e-06	37	51	4	GO:0086005
GeneOntologyBiologicalProcess	actin filament-based movement	CACNA1C MYO5B KCND3 KCNQ1 ABCC9 NOS1AP	2.06e-06	153	51	6	GO:0030048
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 ABCC8 GLRB BCHE APP ADCY1 SLC1A6	2.07e-06	931	51	12	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 ABCC8 GLRB BCHE APP ADCY1 SLC1A6	2.07e-06	931	51	12	GO:0007268
GeneOntologyBiologicalProcess	visual behavior	CACNA1C DRD1 DRD5 ABCC8 APP	2.26e-06	86	51	5	GO:0007632
GeneOntologyBiologicalProcess	trans-synaptic signaling	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 ABCC8 GLRB BCHE APP ADCY1 SLC1A6	2.27e-06	939	51	12	GO:0099537
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	CACNA1C KCND2 KCND3 KCNQ1 NOS1AP	2.40e-06	87	51	5	GO:0086001
GeneOntologyBiologicalProcess	positive regulation of adenylate cyclase activity	CACNA1C DRD1 DRD5 ADCY1	2.84e-06	40	51	4	GO:0045762
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	CACNA1C KCND3 KCNQ1 ABCC9 NOS1AP	3.33e-06	93	51	5	GO:0086003
GeneOntologyBiologicalProcess	synaptic signaling	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 ABCC8 GLRB BCHE APP ADCY1 SLC1A6	3.38e-06	976	51	12	GO:0099536
GeneOntologyBiologicalProcess	blood circulation	CACNA1C DRD1 DRD5 KCND2 KCND3 ABCC8 KCNQ1 ABCC9 APP NOS1AP	3.49e-06	648	51	10	GO:0008015
GeneOntologyBiologicalProcess	potassium ion transport	DRD1 KCND2 KCND3 ABCC8 KCNQ1 ABCC9 NOS1AP	4.53e-06	272	51	7	GO:0006813
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	CACNA1C DRD1 DRD5 ADCY1	5.95e-06	48	51	4	GO:0031281
GeneOntologyBiologicalProcess	locomotory behavior	HEXB CACNA1C DRD1 KCND2 GLRB APP RNF170	6.01e-06	284	51	7	GO:0007626
GeneOntologyBiologicalProcess	positive regulation of lyase activity	CACNA1C DRD1 DRD5 ADCY1	6.47e-06	49	51	4	GO:0051349
GeneOntologyBiologicalProcess	adult walking behavior	CACNA1C DRD1 GLRB RNF170	7.02e-06	50	51	4	GO:0007628
GeneOntologyBiologicalProcess	adenylate cyclase-activating G protein-coupled receptor signaling pathway	DRD1 DRD5 MC2R LPAR2 APP ADCY1	7.42e-06	191	51	6	GO:0007189
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	KCND3 ABCC8 KCNQ1 ABCC9	7.60e-06	51	51	4	GO:1990573
GeneOntologyBiologicalProcess	membrane repolarization during ventricular cardiac muscle cell action potential	KCND3 KCNQ1 NOS1AP	9.45e-06	17	51	3	GO:0098915
GeneOntologyBiologicalProcess	positive regulation of potassium ion transport	DRD1 ABCC8 KCNQ1 NOS1AP	9.57e-06	54	51	4	GO:0043268
GeneOntologyBiologicalProcess	adult locomotory behavior	CACNA1C DRD1 GLRB APP RNF170	9.86e-06	116	51	5	GO:0008344
GeneOntologyBiologicalProcess	circulatory system process	CACNA1C DRD1 DRD5 KCND2 KCND3 ABCC8 KCNQ1 ABCC9 APP NOS1AP	1.03e-05	733	51	10	GO:0003013
GeneOntologyBiologicalProcess	membrane repolarization	KCND2 KCND3 KCNQ1 NOS1AP	1.11e-05	56	51	4	GO:0086009
GeneOntologyBiologicalProcess	mating behavior	HEXB DRD1 DRD5 APP	1.19e-05	57	51	4	GO:0007617
GeneOntologyBiologicalProcess	regulation of potassium ion transport	DRD1 ABCC8 KCNQ1 ABCC9 NOS1AP	1.21e-05	121	51	5	GO:0043266
GeneOntologyBiologicalProcess	learning	CACNA1C DRD1 DRD5 ABCC8 BCHE APP	1.35e-05	212	51	6	GO:0007612
GeneOntologyBiologicalProcess	regulation of adenylate cyclase activity	CACNA1C DRD1 DRD5 ADCY1	1.36e-05	59	51	4	GO:0045761
GeneOntologyBiologicalProcess	walking behavior	CACNA1C DRD1 GLRB RNF170	1.46e-05	60	51	4	GO:0090659
GeneOntologyBiologicalProcess	actin-mediated cell contraction	CACNA1C KCND3 KCNQ1 ABCC9 NOS1AP	1.53e-05	127	51	5	GO:0070252
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	CACNA1C KCND3 KCNQ1 NOS1AP	1.66e-05	62	51	4	GO:0086002
GeneOntologyBiologicalProcess	associative learning	CACNA1C DRD1 DRD5 ABCC8 APP	1.71e-05	130	51	5	GO:0008306
GeneOntologyBiologicalProcess	monoatomic ion transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 GLRB KCNQ1 UBR3 ABCC9 SLC1A6 NOS1AP TFR2	2.11e-05	1374	51	13	GO:0006811
GeneOntologyBiologicalProcess	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C UBR3 NOS1AP	2.12e-05	22	51	3	GO:1902514
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1C KCND3 ABCC8 KCNQ1 ABCC9 SLC1A6	2.13e-05	230	51	6	GO:0098739
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	KCND2 KCND3 ABCC8 KCNQ1 ABCC9 NOS1AP	2.24e-05	232	51	6	GO:0071805
GeneOntologyBiologicalProcess	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C UBR3 NOS1AP	2.44e-05	23	51	3	GO:0061577
GeneOntologyBiologicalProcess	regulation of cyclase activity	CACNA1C DRD1 DRD5 ADCY1	2.55e-05	69	51	4	GO:0031279
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1C KCND3 ABCC8 KCNQ1 ABCC9	2.62e-05	142	51	5	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1C KCND3 ABCC8 KCNQ1 ABCC9	2.62e-05	142	51	5	GO:0098659
GeneOntologyBiologicalProcess	metal ion transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 UBR3 ABCC9 NOS1AP TFR2	2.63e-05	1000	51	11	GO:0030001
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 GLRB KCNQ1 UBR3 ABCC9 NOS1AP	3.07e-05	1017	51	11	GO:0098660
GeneOntologyBiologicalProcess	regulation of lyase activity	CACNA1C DRD1 DRD5 ADCY1	3.18e-05	73	51	4	GO:0051339
GeneOntologyBiologicalProcess	regulation of heart contraction	CACNA1C KCND2 KCND3 KCNQ1 ABCC9 NOS1AP	3.33e-05	249	51	6	GO:0008016
GeneOntologyBiologicalProcess	reproductive behavior	HEXB DRD1 DRD5 APP	3.36e-05	74	51	4	GO:0019098
GeneOntologyBiologicalProcess	learning or memory	CACNA1C DRD1 DRD5 ABCC8 BCHE APP ADCY1	3.49e-05	373	51	7	GO:0007611
GeneOntologyBiologicalProcess	membrane repolarization during cardiac muscle cell action potential	KCND3 KCNQ1 NOS1AP	3.99e-05	27	51	3	GO:0086013
GeneOntologyBiologicalProcess	import into cell	CACNA1C DRD1 SNAP91 KCND3 ABCC8 KCNQ1 ABCC9 APP SNX12 SLC1A6 TFR2	5.05e-05	1074	51	11	GO:0098657
GeneOntologyBiologicalProcess	muscle system process	CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 ABCC9 NOS1AP	5.42e-05	547	51	8	GO:0003012
GeneOntologyBiologicalProcess	muscle contraction	CACNA1C DRD1 KCND2 KCND3 KCNQ1 ABCC9 NOS1AP	5.43e-05	400	51	7	GO:0006936
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell membrane repolarization	KCND3 KCNQ1 NOS1AP	5.52e-05	30	51	3	GO:0099625
GeneOntologyBiologicalProcess	cardiac muscle contraction	CACNA1C KCND3 KCNQ1 ABCC9 NOS1AP	5.70e-05	167	51	5	GO:0060048
GeneOntologyBiologicalProcess	sensitization	DRD1 DRD5	5.97e-05	5	51	2	GO:0046960
GeneOntologyBiologicalProcess	membrane repolarization during action potential	KCND3 KCNQ1 NOS1AP	6.10e-05	31	51	3	GO:0086011
GeneOntologyBiologicalProcess	regulation of protein transport	CACNA1C IL12A SNAP91 P3H1 ABCC8 KCNQ1 APP SNX12	6.39e-05	560	51	8	GO:0051223
GeneOntologyBiologicalProcess	regulation of system process	CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 ABCC9 APP NOS1AP	6.94e-05	734	51	9	GO:0044057
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 GLRB KCNQ1 UBR3 ABCC9 NOS1AP	7.09e-05	1115	51	11	GO:0034220
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	DRD1 DRD5 MC2R LPAR2 APP ADCY1	7.19e-05	286	51	6	GO:0007188
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 UBR3 ABCC9 NOS1AP	7.30e-05	922	51	10	GO:0098662
GeneOntologyBiologicalProcess	cognition	CACNA1C DRD1 DRD5 ABCC8 BCHE APP ADCY1	7.72e-05	423	51	7	GO:0050890
GeneOntologyBiologicalProcess	positive regulation of long-term synaptic potentiation	DRD1 APP ADCY1	8.07e-05	34	51	3	GO:1900273
GeneOntologyBiologicalProcess	activation of adenylate cyclase activity	DRD1 DRD5 ADCY1	8.07e-05	34	51	3	GO:0007190
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 UBR3 ABCC9 NOS1AP	8.73e-05	942	51	10	GO:0098655
GeneOntologyBiologicalProcess	adrenergic receptor signaling pathway	DRD1 DRD5 KCNQ1	8.81e-05	35	51	3	GO:0071875
GeneOntologyBiologicalProcess	heart contraction	CACNA1C KCND2 KCND3 KCNQ1 ABCC9 NOS1AP	9.02e-05	298	51	6	GO:0060047
GeneOntologyBiologicalProcess	monoatomic cation transport	TRPM6 CACNA1C DRD1 KCND2 KCND3 ABCC8 KCNQ1 UBR3 ABCC9 NOS1AP TFR2	9.87e-05	1157	51	11	GO:0006812
GeneOntologyBiologicalProcess	cardiac conduction	CACNA1C KCND3 KCNQ1 ABCC9	1.09e-04	100	51	4	GO:0061337
GeneOntologyBiologicalProcess	heart process	CACNA1C KCND2 KCND3 KCNQ1 ABCC9 NOS1AP	1.10e-04	309	51	6	GO:0003015
GeneOntologyBiologicalProcess	cardiac muscle cell membrane repolarization	KCND3 KCNQ1 NOS1AP	1.42e-04	41	51	3	GO:0099622
GeneOntologyBiologicalProcess	regulation of heart rate by cardiac conduction	CACNA1C KCND3 KCNQ1	1.42e-04	41	51	3	GO:0086091
GeneOntologyBiologicalProcess	adult behavior	CACNA1C DRD1 GLRB APP RNF170	1.43e-04	203	51	5	GO:0030534
GeneOntologyBiologicalProcess	striated muscle contraction	CACNA1C KCND3 KCNQ1 ABCC9 NOS1AP	1.95e-04	217	51	5	GO:0006941
GeneOntologyBiologicalProcess	regulation of metal ion transport	CACNA1C DRD1 ABCC8 KCNQ1 UBR3 ABCC9 NOS1AP	1.99e-04	493	51	7	GO:0010959
GeneOntologyBiologicalProcess	phospholipase C-activating dopamine receptor signaling pathway	DRD1 DRD5	2.13e-04	9	51	2	GO:0060158
GeneOntologyBiologicalProcess	regulation of establishment of protein localization	CACNA1C IL12A SNAP91 P3H1 ABCC8 KCNQ1 APP SNX12	2.29e-04	674	51	8	GO:0070201
GeneOntologyBiologicalProcess	neurotransmitter uptake	DRD1 APP SLC1A6	2.89e-04	52	51	3	GO:0001504
GeneOntologyBiologicalProcess	regulation of heart rate	CACNA1C KCND3 KCNQ1 NOS1AP	2.91e-04	129	51	4	GO:0002027
GeneOntologyBiologicalProcess	regulation of monoatomic cation transmembrane transport	CACNA1C DRD1 KCNQ1 UBR3 ABCC9 NOS1AP	3.36e-04	380	51	6	GO:1904062
GeneOntologyBiologicalProcess	response to light stimulus	CACNA1C IL12A DRD1 DRD5 ABCC8 APP	3.46e-04	382	51	6	GO:0009416
GeneOntologyBiologicalProcess	neurotransmitter transport	DRD1 SNAP91 ABCC8 APP SLC1A6	4.40e-04	259	51	5	GO:0006836
GeneOntologyBiologicalProcess	adenylate cyclase-activating dopamine receptor signaling pathway	DRD1 DRD5	4.59e-04	13	51	2	GO:0007191
GeneOntologyBiologicalProcess	nonassociative learning	DRD1 DRD5	4.59e-04	13	51	2	GO:0046958
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	DRD1 MC2R FZD2	4.63e-04	61	51	3	GO:0007187
GeneOntologyBiologicalProcess	negative regulation of protein localization	IL12A ABCC8 KCNQ1 APP SNX12	4.72e-04	263	51	5	GO:1903828
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	CACNA1C DRD1 ABCC8 KCNQ1 NOS1AP	4.97e-04	266	51	5	GO:0043270
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	DRD1 DRD5 GLRB MC2R OR1L6 KCNQ1 LPAR2 TAS2R38 APP FZD2 ADCY1	5.02e-04	1395	51	11	GO:0007186
GeneOntologyBiologicalProcess	regulation of monoatomic ion transport	CACNA1C DRD1 ABCC8 KCNQ1 UBR3 ABCC9 NOS1AP	5.15e-04	577	51	7	GO:0043269
GeneOntologyBiologicalProcess	regulation of monoatomic ion transmembrane transport	CACNA1C DRD1 KCNQ1 UBR3 ABCC9 NOS1AP	5.50e-04	417	51	6	GO:0034765
GeneOntologyBiologicalProcess	negative regulation of protein transport	IL12A ABCC8 KCNQ1 SNX12	5.55e-04	153	51	4	GO:0051224
GeneOntologyBiologicalProcess	regulation of long-term synaptic potentiation	DRD1 APP ADCY1	6.10e-04	67	51	3	GO:1900271
GeneOntologyBiologicalProcess	cellular response to monoamine stimulus	DRD1 DRD5 APP	6.37e-04	68	51	3	GO:0071868
GeneOntologyBiologicalProcess	cellular response to catecholamine stimulus	DRD1 DRD5 APP	6.37e-04	68	51	3	GO:0071870
GeneOntologyBiologicalProcess	response to catecholamine	DRD1 DRD5 APP	7.84e-04	73	51	3	GO:0071869
GeneOntologyBiologicalProcess	inorganic ion homeostasis	HEXB CACNA1C DRD1 DRD5 KCNQ1 APP TFR2	8.02e-04	622	51	7	GO:0098771
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	HEXB CACNA1C DRD1 DRD5 KCNQ1 APP TFR2	8.02e-04	622	51	7	GO:0006873
GeneOntologyCellularComponent	postsynapse	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 KCND3 USP9X GLRB APP ADCY1 SLC1A6 NOS1AP TFR2 KLHL17	1.14e-08	1018	51	15	GO:0098794
GeneOntologyCellularComponent	sarcolemma	CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9 NOS1AP	3.79e-07	190	51	7	GO:0042383
GeneOntologyCellularComponent	postsynaptic membrane	CACNA1C DRD1 DRD5 SNAP91 KCND2 KCND3 GLRB ADCY1 SLC1A6	5.21e-07	405	51	9	GO:0045211
GeneOntologyCellularComponent	synaptic membrane	CACNA1C DRD1 DRD5 SNAP91 KCND2 KCND3 GLRB LPAR2 ADCY1 SLC1A6	1.20e-06	583	51	10	GO:0097060
GeneOntologyCellularComponent	plasma membrane protein complex	CACNA1C DRD1 SNAP91 KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 C9 TFR2	2.35e-06	785	51	11	GO:0098797
GeneOntologyCellularComponent	membrane raft	CACNA1C DRD1 KCND2 KCND3 KCNQ1 APP ADCY1 NOS1AP	2.49e-06	362	51	8	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	CACNA1C DRD1 KCND2 KCND3 KCNQ1 APP ADCY1 NOS1AP	2.59e-06	364	51	8	GO:0098857
GeneOntologyCellularComponent	potassium channel complex	KCND2 KCND3 ABCC8 KCNQ1 ABCC9	5.42e-06	104	51	5	GO:0034705
GeneOntologyCellularComponent	caveola	CACNA1C DRD1 KCND2 KCND3 NOS1AP	7.45e-06	111	51	5	GO:0005901
GeneOntologyCellularComponent	cell body	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 KCND3 PITPNM3 KCNQ1 APP KLHL17	1.17e-05	929	51	11	GO:0044297
GeneOntologyCellularComponent	potassium ion-transporting ATPase complex	ABCC8 ABCC9	1.75e-05	3	51	2	GO:0031004
GeneOntologyCellularComponent	cation channel complex	CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9	2.23e-05	235	51	6	GO:0034703
GeneOntologyCellularComponent	glutamatergic synapse	CACNA1C DRD1 DRD5 MYO5B KCND2 LPAR2 ADCY1 SLC1A6 NOS1AP KLHL17	2.35e-05	817	51	10	GO:0098978
GeneOntologyCellularComponent	dendritic spine	DRD1 DRD5 MYO5B KCND2 KCND3 APP	2.64e-05	242	51	6	GO:0043197
GeneOntologyCellularComponent	postsynaptic specialization	CACNA1C DRD5 SNAP91 KCND2 KCND3 GLRB ADCY1 KLHL17	2.73e-05	503	51	8	GO:0099572
GeneOntologyCellularComponent	neuronal cell body	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 KCND3 KCNQ1 APP KLHL17	2.83e-05	835	51	10	GO:0043025
GeneOntologyCellularComponent	plasma membrane raft	CACNA1C DRD1 KCND2 KCND3 NOS1AP	2.91e-05	147	51	5	GO:0044853
GeneOntologyCellularComponent	neuron spine	DRD1 DRD5 MYO5B KCND2 KCND3 APP	2.96e-05	247	51	6	GO:0044309
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	3.49e-05	378	51	7	GO:0034702
GeneOntologyCellularComponent	inward rectifying potassium channel	ABCC8 ABCC9	3.49e-05	4	51	2	GO:0008282
GeneOntologyCellularComponent	T-tubule	CACNA1C KCND2 ABCC9 NOS1AP	4.13e-05	79	51	4	GO:0030315
GeneOntologyCellularComponent	membrane protein complex	CACNA1C DRD1 SNAP91 KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 C9 SNX12 SLC1A6 TFR2	4.53e-05	1498	51	13	GO:0098796
GeneOntologyCellularComponent	postsynaptic specialization membrane	CACNA1C DRD5 KCND2 KCND3 ADCY1	1.28e-04	201	51	5	GO:0099634
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1C DRD1 DRD5 SNAP91 MYO5B KCND2 KCND3 GLRB KCNQ1 APP KLHL17	1.49e-04	1228	51	11	GO:0036477
GeneOntologyCellularComponent	dendrite	CACNA1C DRD1 DRD5 MYO5B KCND2 KCND3 GLRB APP KLHL17	2.05e-04	858	51	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CACNA1C DRD1 DRD5 MYO5B KCND2 KCND3 GLRB APP KLHL17	2.08e-04	860	51	9	GO:0097447
GeneOntologyCellularComponent	presynapse	CACNA1C DRD1 SNAP91 ABCC8 LPAR2 APP ADCY1 SLC1A6 NOS1AP	2.60e-04	886	51	9	GO:0098793
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	2.63e-04	523	51	7	GO:1902495
GeneOntologyCellularComponent	transporter complex	CACNA1C KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9	3.57e-04	550	51	7	GO:1990351
GeneOntologyCellularComponent	nuclear envelope lumen	BCHE APP	5.21e-04	14	51	2	GO:0005641
GeneOntologyCellularComponent	presynaptic membrane	CACNA1C DRD1 SNAP91 LPAR2 SLC1A6	5.63e-04	277	51	5	GO:0042734
GeneOntologyCellularComponent	GABA-ergic synapse	DRD1 KCND2 KCND3 GLRB	6.85e-04	164	51	4	GO:0098982
GeneOntologyCellularComponent	dendritic shaft	CACNA1C DRD1 APP	7.85e-04	74	51	3	GO:0043198
GeneOntologyCellularComponent	endoplasmic reticulum lumen	IL12A FAM20C P3H1 BCHE APP	1.27e-03	332	51	5	GO:0005788
GeneOntologyCellularComponent	voltage-gated potassium channel complex	KCND2 KCND3 KCNQ1	1.43e-03	91	51	3	GO:0008076
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	KCND2 KCND3	2.27e-03	29	51	2	GO:0097038
GeneOntologyCellularComponent	postsynaptic density	CACNA1C DRD5 SNAP91 ADCY1 KLHL17	4.75e-03	451	51	5	GO:0014069
GeneOntologyCellularComponent	presynaptic active zone	SNAP91 LPAR2 APP	4.94e-03	141	51	3	GO:0048786
GeneOntologyCellularComponent	endosome lumen	IL12A APP	4.94e-03	43	51	2	GO:0031904
GeneOntologyCellularComponent	parallel fiber to Purkinje cell synapse	SNAP91 SLC1A6	4.94e-03	43	51	2	GO:0098688
GeneOntologyCellularComponent	cell surface	CACNA1C IL12A DRD1 APMAP GLRB LPAR2 APP TFR2	5.16e-03	1111	51	8	GO:0009986
GeneOntologyCellularComponent	axon	CACNA1C DRD1 DRD5 BLOC1S4 SNAP91 USP9X APP	5.63e-03	891	51	7	GO:0030424
GeneOntologyCellularComponent	cilium	DRD1 CFAP251 DRD5 USP9X RTTN KCNQ1 APP	5.87e-03	898	51	7	GO:0005929
GeneOntologyCellularComponent	asymmetric synapse	CACNA1C DRD5 SNAP91 ADCY1 KLHL17	6.00e-03	477	51	5	GO:0032279
GeneOntologyCellularComponent	brush border	TRPM6 DRD5 MYO5B	6.08e-03	152	51	3	GO:0005903
GeneOntologyCellularComponent	cation-transporting ATPase complex	ABCC8 ABCC9	6.38e-03	49	51	2	GO:0090533
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	SNAP91 MYO5B ADCY1	6.42e-03	155	51	3	GO:0098685
GeneOntologyCellularComponent	postsynaptic density membrane	CACNA1C DRD5 ADCY1	6.65e-03	157	51	3	GO:0098839
GeneOntologyCellularComponent	ATPase dependent transmembrane transport complex	ABCC8 ABCC9	7.98e-03	55	51	2	GO:0098533
GeneOntologyCellularComponent	neuron to neuron synapse	CACNA1C DRD5 SNAP91 ADCY1 KLHL17	8.77e-03	523	51	5	GO:0098984
Domain	Sulphorea_rcpt	ABCC8 ABCC9	7.60e-06	2	52	2	IPR000388
Domain	Ion_trans_dom	TRPM6 CACNA1C KCND2 KCND3 KCNQ1	1.60e-05	114	52	5	IPR005821
Domain	Ion_trans	TRPM6 CACNA1C KCND2 KCND3 KCNQ1	1.60e-05	114	52	5	PF00520
Domain	DUF3399	KCND2 KCND3	2.28e-05	3	52	2	PF11879
Domain	K_chnl_volt-dep_Kv4	KCND2 KCND3	2.28e-05	3	52	2	IPR003975
Domain	Shal-type	KCND2 KCND3	2.28e-05	3	52	2	PF11601
Domain	Shal-type_N	KCND2 KCND3	2.28e-05	3	52	2	IPR021645
Domain	K_chnl_volt-dep_Kv4_C	KCND2 KCND3	2.28e-05	3	52	2	IPR024587
Domain	Dopamine_rcpt	DRD1 DRD5	7.56e-05	5	52	2	IPR000929
Domain	VG_K_chnl	KCND2 KCND3 KCNQ1	1.05e-04	33	52	3	IPR028325
Domain	7TM_GPCR_Srsx	DRD1 DRD5 MC2R LPAR2	2.66e-04	112	52	4	SM01381
Domain	Channel_four-helix_dom	CACNA1C KCND2 KCND3	5.36e-04	57	52	3	IPR027359
Domain	-	CACNA1C KCND2 KCND3	5.36e-04	57	52	3	1.20.120.350
Domain	ABC_membrane	ABCC8 ABCC9	2.02e-03	24	52	2	PF00664
Domain	K_chnl_volt-dep_Kv	KCND2 KCND3	2.55e-03	27	52	2	IPR003968
Domain	ABC_TM1F	ABCC8 ABCC9	2.74e-03	28	52	2	PS50929
Domain	ABC1_TM_dom	ABCC8 ABCC9	2.74e-03	28	52	2	IPR011527
Domain	-	IPO9 PSME4 USP9X RTTN	3.37e-03	222	52	4	1.25.10.10
Domain	ABC_transporter_CS	ABCC8 ABCC9	6.10e-03	42	52	2	IPR017871
Domain	ARM-like	IPO9 PSME4 USP9X RTTN	6.71e-03	270	52	4	IPR011989
Domain	ABC_tran	ABCC8 ABCC9	7.90e-03	48	52	2	PF00005
Domain	ABC_TRANSPORTER_2	ABCC8 ABCC9	7.90e-03	48	52	2	PS50893
Domain	ABC_TRANSPORTER_1	ABCC8 ABCC9	8.22e-03	49	52	2	PS00211
Pathway	REACTOME_NEURONAL_SYSTEM	KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 BCHE ADCY1 SLC1A6	3.26e-06	411	43	9	M735
Pathway	REACTOME_NEURONAL_SYSTEM	KCND2 KCND3 ABCC8 GLRB KCNQ1 ABCC9 ADCY1 SLC1A6	6.57e-06	335	43	8	MM14503
Pathway	REACTOME_POTASSIUM_CHANNELS	KCND2 KCND3 ABCC8 KCNQ1 ABCC9	1.14e-05	98	43	5	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	KCND2 KCND3 ABCC8 KCNQ1 ABCC9	1.46e-05	103	43	5	M1073
Pathway	REACTOME_CARDIAC_CONDUCTION	CACNA1C KCND2 KCND3 KCNQ1 ABCC9	1.46e-05	103	43	5	MM15196
Pathway	REACTOME_CARDIAC_CONDUCTION	CACNA1C KCND2 KCND3 KCNQ1 ABCC9	4.49e-05	130	43	5	M27454
Pathway	REACTOME_DOPAMINE_RECEPTORS	DRD1 DRD5	9.04e-05	5	43	2	M27301
Pathway	REACTOME_DOPAMINE_RECEPTORS	DRD1 DRD5	9.04e-05	5	43	2	MM15007
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNA1C KCND2 KCND3 KCNQ1 ABCC9	1.39e-04	165	43	5	MM15026
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCND2 KCND3	1.89e-04	7	43	2	M27457
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCND2 KCND3	1.89e-04	7	43	2	MM15199
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCND2 KCND3 KCNQ1	2.60e-04	41	43	3	MM14546
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCND2 KCND3 KCNQ1	3.00e-04	43	43	3	M1056
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNA1C KCND2 KCND3 KCNQ1 ABCC9	3.64e-04	203	43	5	M5485
Pathway	REACTOME_GPCR_LIGAND_BINDING	DRD1 DRD5 MC2R LPAR2 TAS2R38 APP FZD2	4.56e-04	463	43	7	M507
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1C APP	8.08e-04	14	43	2	M47692
Pathway	REACTOME_PHASE_2_PLATEAU_PHASE	CACNA1C KCNQ1	8.08e-04	14	43	2	MM15198
Pathway	REACTOME_PHASE_2_PLATEAU_PHASE	CACNA1C KCNQ1	9.31e-04	15	43	2	M27456
Pathway	REACTOME_SIGNALING_BY_GPCR	DRD1 DRD5 MC2R LPAR2 TAS2R38 APP FZD2 ADCY1	1.12e-03	702	43	8	M746
Pubmed	Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers.	DRD1 DRD5 APP	3.15e-09	3	52	3	21115476
Pubmed	Brugada Syndrome	CACNA1C KCND2 KCND3 ABCC9	4.62e-08	24	52	4	20301690
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1C KCND2 KCND3 ABCC8 KCNQ1 ABCC9	6.40e-08	139	52	6	16985003
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	CACNA1C KCND2 KCND3 KCNQ1	1.99e-07	34	52	4	26378152
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	DRD1 DRD5 BCHE ADCY1 SLC1A6	9.44e-07	118	52	5	19156168
Pubmed	Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.	KCND2 KCND3 KCNQ1	1.13e-06	14	52	3	23542581
Pubmed	Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.	CACNA1C KCND2 KCND3	1.42e-06	15	52	3	10479680
Pubmed	Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.	KCND2 KCND3	2.19e-06	2	52	2	34386734
Pubmed	Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes.	ABCC8 ABCC9	2.19e-06	2	52	2	22844491
Pubmed	Modulation of 'A'-type K+ current by rodent and human forms of amyloid beta protein.	KCND2 APP	2.19e-06	2	52	2	18463498
Pubmed	The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.	DRD1 DRD5	2.19e-06	2	52	2	21893192
Pubmed	Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors.	DRD1 DRD5	2.19e-06	2	52	2	26763483
Pubmed	Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory.	DRD1 DRD5	2.19e-06	2	52	2	26174222
Pubmed	Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity.	ABCC8 ABCC9	2.19e-06	2	52	2	26181369
Pubmed	PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation.	DRD1 DRD5	2.19e-06	2	52	2	26807952
Pubmed	Epilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link?	DRD1 APP	2.19e-06	2	52	2	27701029
Pubmed	Role of the extracellular amino terminus and first membrane-spanning helix of dopamine D1 and D5 receptors in shaping ligand selectivity and efficacy.	DRD1 DRD5	2.19e-06	2	52	2	19786093
Pubmed	L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations.	CACNA1C APP	2.19e-06	2	52	2	20413896
Pubmed	Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.	KCND2 KCND3	2.19e-06	2	52	2	9843794
Pubmed	The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport.	DRD1 DRD5	2.19e-06	2	52	2	24552847
Pubmed	D1/D5 modulation of synaptic NMDA receptor currents.	DRD1 DRD5	2.19e-06	2	52	2	19279248
Pubmed	Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease.	BCHE APP	2.19e-06	2	52	2	22157615
Pubmed	Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.	CACNA1C DRD1	2.19e-06	2	52	2	29089442
Pubmed	Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.	DRD1 DRD5	2.19e-06	2	52	2	26186971
Pubmed	Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.	ABCC8 ABCC9	2.19e-06	2	52	2	33529173
Pubmed	Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.	CACNA1C APP	2.19e-06	2	52	2	20016080
Pubmed	Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory.	DRD1 DRD5	2.19e-06	2	52	2	24843151
Pubmed	Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.	DRD1 DRD5	2.19e-06	2	52	2	1831904
Pubmed	Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.	KCND2 KCND3	2.19e-06	2	52	2	17122053
Pubmed	Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome.	KCND2 KCND3	2.19e-06	2	52	2	15563876
Pubmed	Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity.	DRD1 DRD5	2.19e-06	2	52	2	13679419
Pubmed	Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.	DRD1 DRD5	2.19e-06	2	52	2	25429131
Pubmed	Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.	KCND2 KCND3	2.19e-06	2	52	2	26196737
Pubmed	Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3.	KCND2 KCND3	2.19e-06	2	52	2	10942109
Pubmed	Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates.	DRD1 DRD5	2.19e-06	2	52	2	19204052
Pubmed	Agonist-dependent and -independent dopamine-1-like receptor signalling differentially regulates downstream effectors.	DRD1 DRD5	2.19e-06	2	52	2	25154512
Pubmed	Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.	HEXB APP	2.19e-06	2	52	2	22496568
Pubmed	Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice.	DRD1 DRD5	2.19e-06	2	52	2	11823893
Pubmed	Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.	DRD1 DRD5	2.19e-06	2	52	2	20180564
Pubmed	Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase.	DRD1 DRD5	2.19e-06	2	52	2	11500503
Pubmed	Identification of a cyclic adenosine 3',5'-monophosphate-dependent protein kinase phosphorylation site in the carboxy terminal tail of human D1 dopamine receptor.	DRD1 DRD5	6.57e-06	3	52	2	7609904
Pubmed	Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.	DRD1 DRD5	6.57e-06	3	52	2	19171671
Pubmed	Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.	DRD1 DRD5	6.57e-06	3	52	2	22710646
Pubmed	Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.	KCND2 KCND3	6.57e-06	3	52	2	20371829
Pubmed	Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.	KCND2 KCND3	6.57e-06	3	52	2	30758987
Pubmed	Tau binding protein CAPON induces tau aggregation and neurodegeneration.	APP NOS1AP	6.57e-06	3	52	2	31160584
Pubmed	An NGS-based genotyping in LQTS; minor genes are no longer minor.	CACNA1C KCNQ1	6.57e-06	3	52	2	32681117
Pubmed	Role of heteromultimers in the generation of myocardial transient outward K+ currents.	KCND2 KCND3	6.57e-06	3	52	2	11909823
Pubmed	Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice.	DRD1 DRD5	6.57e-06	3	52	2	25339698
Pubmed	Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor.	DRD1 DRD5	6.57e-06	3	52	2	18172057
Pubmed	Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.	KCND2 KCND3	6.57e-06	3	52	2	18371079
Pubmed	Functional roles of KATP channel subunits in metabolic inhibition.	ABCC8 ABCC9	6.57e-06	3	52	2	23624089
Pubmed	VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.	DRD1 APP	6.57e-06	3	52	2	27460146
Pubmed	Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.	APP SNX12	6.57e-06	3	52	2	22709416
Pubmed	The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide.	SNAP91 APP	6.57e-06	3	52	2	19450545
Pubmed	I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.	KCND2 KCND3	6.57e-06	3	52	2	22815518
Pubmed	A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.	ABCC8 ABCC9	6.57e-06	3	52	2	8630239
Pubmed	Dopamine receptor genes and migraine with and without aura: an association study.	DRD1 DRD5	6.57e-06	3	52	2	12047334
Pubmed	Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons.	DRD1 DRD5	6.57e-06	3	52	2	12867509
Pubmed	A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.	KCND2 KCND3	6.57e-06	3	52	2	22615428
Pubmed	Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).	KCND2 KCND3	6.57e-06	3	52	2	10729221
Pubmed	Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.	DRD5 MYO5B BCHE APP	8.22e-06	85	52	4	25131634
Pubmed	Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors.	DRD1 DRD5	1.31e-05	4	52	2	16962565
Pubmed	Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.	HEXB APP	1.31e-05	4	52	2	20864542
Pubmed	Assembly limits the pharmacological complexity of ATP-sensitive potassium channels.	ABCC8 ABCC9	1.31e-05	4	52	2	11825905
Pubmed	Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.	DRD1 DRD5	1.31e-05	4	52	2	20164562
Pubmed	Whole-genome association study of bipolar disorder.	CACNA1C MYO5B	1.31e-05	4	52	2	18317468
Pubmed	Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes.	DRD1 DRD5	1.31e-05	4	52	2	12967601
Pubmed	A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.	ABCC8 ABCC9	1.31e-05	4	52	2	8798681
Pubmed	Dopamine genes and pathological gambling in discordant sib-pairs.	DRD1 DRD5	1.31e-05	4	52	2	17394052
Pubmed	Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.	KCND2 KCND3	1.31e-05	4	52	2	26311767
Pubmed	Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium.	ABCC8 ABCC9	1.31e-05	4	52	2	12356945
Pubmed	nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.	APP NOS1AP	1.31e-05	4	52	2	29577585
Pubmed	Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.	DRD1 DRD5	1.31e-05	4	52	2	25049074
Pubmed	Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.	KCND2 KCND3	1.31e-05	4	52	2	15662035
Pubmed	Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart.	ABCC8 ABCC9	1.31e-05	4	52	2	16085792
Pubmed	Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.	ABCC8 ABCC9	1.31e-05	4	52	2	10022826
Pubmed	Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.	ABCC8 ABCC9	1.31e-05	4	52	2	28842488
Pubmed	IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.	KCND2 KCND3	1.31e-05	4	52	2	26152125
Pubmed	Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.	KCND2 KCND3	1.31e-05	4	52	2	14980207
Pubmed	Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.	KCNQ1 NOS1AP	1.31e-05	4	52	2	27988371
Pubmed	Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.	DRD1 DRD5	1.31e-05	4	52	2	18403039
Pubmed	Dopamine receptors: from structure to function.	DRD1 DRD5	2.19e-05	5	52	2	9457173
Pubmed	[Dopamine receptor signaling regulates human osteoclastogenesis].	DRD1 DRD5	2.19e-05	5	52	2	23445730
Pubmed	Evidence against dopamine D1/D2 receptor heteromers.	DRD1 DRD5	2.19e-05	5	52	2	25560761
Pubmed	Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes.	DRD1 DRD5	2.19e-05	5	52	2	22219295
Pubmed	Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.	KCND2 KCND3	2.19e-05	5	52	2	19213956
Pubmed	Redundant catecholamine signaling consolidates fear memory via phospholipase C.	DRD1 DRD5	2.19e-05	5	52	2	22323706
Pubmed	The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients.	DRD1 DRD5	2.19e-05	5	52	2	26597879
Pubmed	Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort.	DRD1 DRD5	2.19e-05	5	52	2	19105202
Pubmed	Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.	DRD1 DRD5	2.19e-05	5	52	2	12509874
Pubmed	Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo.	DRD1 DRD5	2.19e-05	5	52	2	20038975
Pubmed	Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.	DRD1 DRD5	2.19e-05	5	52	2	20714340
Pubmed	Upregulation of renal D5 dopamine receptor ameliorates the hypertension in D3 dopamine receptor-deficient mice.	DRD1 DRD5	2.19e-05	5	52	2	23753418
Pubmed	The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.	KCND2 KCND3	2.19e-05	5	52	2	16239150
Pubmed	Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during pre- and postnatal development.	DRD1 DRD5	2.19e-05	5	52	2	17509542
Pubmed	Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.	DRD1 DRD5	2.19e-05	5	52	2	18083900
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	IPO9 MYO5B P3H1 USP9X PDP1 POLR2B UBR3 APP NOS1AP	2.29e-05	1049	52	9	27880917
Pubmed	Ion channel expression in the developing enteric nervous system.	CACNA1C KCND2 KCND3	2.36e-05	37	52	3	25798587
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCND2 KCND3 KCNQ1	3.00e-05	40	52	3	16382104
GeneFamily	Dopamine receptors	DRD1 DRD5	4.28e-05	5	38	2	181
GeneFamily	Potassium voltage-gated channels	KCND2 KCND3 KCNQ1	8.02e-05	40	38	3	274
GeneFamily	ATP binding cassette subfamily C	ABCC8 ABCC9	3.31e-04	13	38	2	807
Coexpression	GSE7764_IL15_NK_CELL_24H_VS_SPLENOCYTE_UP	BLOC1S4 APMAP PDP1 POLR2B RTTN SPTLC1	2.48e-06	200	51	6	M5725
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C KCND2 KCND3 ABCC9 GREB1	2.47e-06	185	52	5	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 KCND2 ABCC8 BCHE ADCY1	3.28e-06	196	52	5	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 KCND2 ABCC8 BCHE ADCY1	3.28e-06	196	52	5	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GALNTL6 KCND3 GREB1 NOS1AP	4.21e-05	166	52	4	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KCND3 ABCC8 GREB1 PSKH2	4.31e-05	167	52	4	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SNAP91 KCND3 ABCC8 GREB1	4.52e-05	169	52	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 KCND2 ABCC8 ADCY1	4.84e-05	172	52	4	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 KCND2 ABCC8 ADCY1	4.84e-05	172	52	4	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	CFAP251 IPO9 SPTLC1 APP	5.06e-05	174	52	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 KCND3 FZD2 SLC1A6	5.18e-05	175	52	4	59249c9e83952d7277010e7be3c779e26399eb5d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 KCND3 FZD2 SLC1A6	5.18e-05	175	52	4	b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	CFAP251 SPTLC1 APP FZD2	5.29e-05	176	52	4	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C PLEKHG3 ABCC8 ABCC9	5.53e-05	178	52	4	066dbc4cc2083c549d98122ed44707127f34d582
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	CACNA1C ABCC9 ADCY1 NOS1AP	5.90e-05	181	52	4	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FAM20C KCNQ1 GREB1 TFR2	6.42e-05	185	52	4	1d874608aa2062024323512f68889219471b2f00
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 ABCC8 PITPNM3 ADCY1	6.56e-05	186	52	4	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|Mesenchymal_cells / Lineage and Cell class	IL12A FAM20C ABCC9 TFR2	6.69e-05	187	52	4	e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 ABCC8 KCNQ1 ADCY1	6.83e-05	188	52	4	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 ABCC8 KCNQ1 ADCY1	6.83e-05	188	52	4	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 ABCC8 KCNQ1 ADCY1	6.83e-05	188	52	4	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC8 PITPNM3 ADCY1 SLC1A6	6.98e-05	189	52	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 ABCC8 KCNQ1 ADCY1	6.98e-05	189	52	4	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 ABCC8 KCNQ1 ADCY1	6.98e-05	189	52	4	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MC2R GREB1 C9	7.23e-05	69	52	3	8e14f411cbaea9cb9bcb9351b2421e71d5828ccc
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MC2R GREB1 C9	7.23e-05	69	52	3	2fd6df70cdc7477e4a3ebdf4537279a727ab1214
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MC2R GREB1 C9	7.23e-05	69	52	3	bc3170409d107c39534581d2f0b8d75f93519113
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 KCND2 ABCC8 ADCY1	7.27e-05	191	52	4	97fb4232417a39801e87725755fd16a57c250209
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNAP91 KCND2 ABCC8 ADCY1	7.27e-05	191	52	4	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C MYO5B ABCC8 ADCY1	7.41e-05	192	52	4	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 ABCC8 KCNQ1 ADCY1	7.41e-05	192	52	4	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C MYO5B ABCC8 ADCY1	7.41e-05	192	52	4	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KCND2 PLEKHG3 ABCC9 BCHE	7.41e-05	192	52	4	5000440dc1ed17e7474d340921bdff945646f27e
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 ABCC8 KCNQ1 ADCY1	7.41e-05	192	52	4	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 PITPNM3 ADCY1 SLC1A6	7.56e-05	193	52	4	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C APP FZD2 ADCY1	8.03e-05	196	52	4	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C SNAP91 KCND2 GLRB	8.35e-05	198	52	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
Computational	Neighborhood of RAB10	IPO9 APMAP SPTLC1 STARD7 SNX12	1.82e-04	176	33	5	GCM_RAB10
Computational	Neighborhood of BAG5	APMAP SPTLC1 STARD7	2.07e-04	38	33	3	GCM_BAG5
Computational	Genes upregulated in subsets of cells of a given type within various tumors	HEXB APMAP APP	4.68e-04	50	33	3	GAVISH_3CA_MALIGNANT_METAPROGRAM_10_PROTEIN_MATURATION
Drug	NBQX	CACNA1C DRD1 DRD5 SNAP91 KCND2 GLRB	5.67e-08	90	52	6	CID003272523
Drug	corydaline	DRD1 DRD5 BCHE	1.12e-07	5	52	3	CID000101301
Drug	isoproterenol	CACNA1C DRD1 DRD5 MYO5B KCND3 ABCC8 SPTLC1 KCNQ1 ABCC9 FZD2 ADCY1	2.62e-07	669	52	11	CID000003779
Drug	5,6-benzoquinoline	DRD1 DRD5 KCNQ1 BCHE	2.95e-07	25	52	4	CID000006796
Drug	L-745,870	DRD1 DRD5 ADCY1	6.24e-07	8	52	3	CID005311200
Drug	cyclo(Leu-Gly)	DRD1 DRD5 ABCC8	1.33e-06	10	52	3	CID000002902
Drug	Cyclic AMP	IL12A FAM20C DRD1 DRD5 KCND2 MC2R ADCY1	1.43e-06	247	52	7	ctd:D000242
Drug	acetylcholine	DRD1 DRD5 ABCC8 GLRB BCHE LPAR2 ADCY1 XAB2	1.51e-06	361	52	8	CID000000187
Drug	N-N-C	DRD1 DRD5 ABCC8 ABCC9	2.54e-06	42	52	4	CID005278688
Drug	5-HTP	DRD1 DRD5 ABCC8 GLRB ABCC9	3.42e-06	101	52	5	CID000000144
Drug	azaperone	DRD1 DRD5 SNAP91	4.02e-06	14	52	3	CID000015443
Drug	tiapride	DRD1 DRD5 BCHE	4.02e-06	14	52	3	CID000005467
Drug	benzimidazol-2-one	HEXB DRD1 DRD5	4.02e-06	14	52	3	CID000162542
Drug	Potassium	KCND2 ABCC8 KCNQ1 ABCC9 APP	4.34e-06	106	52	5	ctd:D011188
Drug	V ms	CACNA1C KCND2 KCND3 KCNQ1	4.75e-06	49	52	4	CID005289556
Drug	SKF 75670	DRD1 DRD5 ADCY1	5.01e-06	15	52	3	CID000173870
Drug	butamben	CACNA1C KCND2 KCND3	5.01e-06	15	52	3	CID000002482
Drug	AC1L2AAS	DRD1 DRD5 ADCY1	5.01e-06	15	52	3	CID000068714
Drug	columbamine	DRD1 DRD5	5.12e-06	2	52	2	CID000072309
Drug	dehydrocorybulbine	DRD1 DRD5	5.12e-06	2	52	2	CID005316439
Drug	zelandopam	DRD1 DRD5	5.12e-06	2	52	2	CID003078104
Drug	tetrahydrocolumbamine	DRD1 DRD5	5.12e-06	2	52	2	CID000010220
Drug	8-OH-DPAT	DRD1 DRD5 ABCC8 ABCC9 ADCY1	7.05e-06	117	52	5	CID000001220
Drug	sodium	TRPM6 CACNA1C IL12A KCND2 KCND3 PDP1 SPTLC1 KCNQ1 BCHE ADCY1 SLC1A6	7.45e-06	944	52	11	CID000000923
Drug	Ro 41-9067	DRD1 DRD5 ADCY1	1.06e-05	19	52	3	CID000125800
Drug	SB 200646A	DRD1 DRD5 MC2R	1.06e-05	19	52	3	CID000126769
Drug	YM435	DRD1 DRD5 ADCY1	1.25e-05	20	52	3	CID000132119
Drug	ethyltrimethylammonium	KCND2 GLRB BCHE	1.45e-05	21	52	3	CID000033993
Drug	geneserine	BCHE APP	1.53e-05	3	52	2	CID000065719
Drug	AC1LR3WA	DRD1 DRD5	1.53e-05	3	52	2	CID001361946
Drug	Berupipam	DRD1 DRD5	1.53e-05	3	52	2	CID000066002
Drug	carphenazine	DRD1 DRD5	1.53e-05	3	52	2	CID000018104
Drug	U-99363E	DRD1 DRD5	1.53e-05	3	52	2	CID000133107
Drug	piperidine phosphate	BCHE APP	1.53e-05	3	52	2	CID003083646
Drug	Cholinesterase Inhibitors	BCHE APP	1.53e-05	3	52	2	ctd:D002800
Drug	Carphenazine	DRD1 DRD5	1.53e-05	3	52	2	DB01038
Drug	(-)-Physovenine	BCHE APP	1.53e-05	3	52	2	CID000110765
Drug	P-DMPA	PDP1 BCHE	1.53e-05	3	52	2	CID000119152
Drug	ecopipam	DRD1 DRD5	1.53e-05	3	52	2	ctd:C058081
Drug	N-methyl-DL-aspartic acid	CACNA1C DRD1 DRD5 KCND2 GLRB BCHE APP ADCY1 NOS1AP	1.56e-05	655	52	9	CID000004376
Drug	benzilate	CACNA1C BCHE ADCY1 NOS1AP	1.57e-05	66	52	4	CID000201538
Drug	BP 897	DRD1 DRD5 BCHE	1.68e-05	22	52	3	CID003038494
Drug	TL-99	DRD1 DRD5 ADCY1	2.20e-05	24	52	3	CID000122132
Drug	N-n-propylnorapomorphine	DRD1 DRD5 ADCY1	2.49e-05	25	52	3	CID000030137
Drug	AC1MBZ1C	CACNA1C DRD1 DRD5 KCND3 MC2R LPAR2 ADCY1	2.69e-05	387	52	7	CID000003541
Drug	methiothepin	DRD1 DRD5 LPAR2 ADCY1	2.89e-05	77	52	4	CID000004106
Drug	8-bromo-cAMP	CACNA1C DRD1 DRD5 KCND2 MC2R ADCY1	2.99e-05	264	52	6	CID000001912
Drug	haloperidol	TRPM6 CACNA1C DRD1 DRD5 ABCC8 LPAR2 ADCY1	3.01e-05	394	52	7	CID000003559
Drug	AC1LD65L	BCHE APP	3.06e-05	4	52	2	CID000612743
Drug	dimethocaine	DRD1 DRD5	3.06e-05	4	52	2	CID000007177
Drug	MK-458	DRD1 DRD5	3.06e-05	4	52	2	CID000057532
Drug	SCH 40853	DRD1 DRD5	3.06e-05	4	52	2	CID003035575
Drug	DK-118	DRD1 DRD5	3.06e-05	4	52	2	CID000145953
Drug	U 101958	DRD1 DRD5	3.06e-05	4	52	2	CID005311492
Drug	RU 24926	DRD1 DRD5 ADCY1	3.16e-05	27	52	3	CID000122203
Drug	triflupromazine	DRD1 DRD5 PDP1	3.16e-05	27	52	3	CID000005568
Drug	tetradotoxin	CACNA1C DRD1 DRD5 KCND2 KCND3 GLRB BCHE	5.09e-05	428	52	7	CID000020382
Drug	SCH 24518	DRD1 DRD5	5.09e-05	5	52	2	CID000146265
Drug	dimethylphosphinate	PDP1 BCHE	5.09e-05	5	52	2	CID000076777
Drug	thioformamide	ABCC8 ABCC9	5.09e-05	5	52	2	CID003005587
Drug	DH97	DRD1 DRD5	5.09e-05	5	52	2	CID003467177
Drug	AMMTC	DRD1 DRD5	5.09e-05	5	52	2	CID005311004
Drug	tilozepine	DRD1 DRD5	5.09e-05	5	52	2	CID000172286
Drug	2-di-n-propylaminoindan	DRD1 DRD5	5.09e-05	5	52	2	CID000130402
Drug	verruculogen	KCND2 KCND3	5.09e-05	5	52	2	CID000104862
Drug	mezilamine	DRD1 DRD5	5.09e-05	5	52	2	CID000068678
Drug	C9H11N3O2	DRD1 DRD5	5.09e-05	5	52	2	CID000123703
Drug	NNC-687	DRD1 DRD5	5.09e-05	5	52	2	CID000164252
Drug	SKF 77434	DRD1 DRD5	5.09e-05	5	52	2	CID000001241
Drug	proterguride	DRD1 DRD5	5.09e-05	5	52	2	CID000071999
Drug	NO 756	DRD1 DRD5	5.09e-05	5	52	2	CID000129967
Drug	Levodopa	DRD1 DRD5	5.09e-05	5	52	2	DB01235
Drug	SKF 82957	DRD1 DRD5	5.09e-05	5	52	2	CID000130844
Drug	SKF85174	DRD1 DRD5	5.09e-05	5	52	2	CID000132435
Drug	l-CSL	DRD1 DRD5	5.09e-05	5	52	2	CID006918538
Drug	3-iodobenzamide	DRD1 DRD5	5.09e-05	5	52	2	CID000202425
Drug	dihydrexidine	DRD1 DRD5	5.09e-05	5	52	2	ctd:C061532
Drug	dazopride	DRD1 DRD5	5.09e-05	5	52	2	CID000054801
Drug	Fenoldopam	DRD1 DRD5	5.09e-05	5	52	2	DB00800
Drug	azapride	DRD1 DRD5	5.09e-05	5	52	2	CID003036441
Drug	piquindone	DRD1 DRD5	5.09e-05	5	52	2	CID000121903
Drug	A 68930	DRD1 DRD5	5.09e-05	5	52	2	ctd:C065380
Drug	trihexyphenidyl	DRD1 DRD5 BCHE	5.32e-05	32	52	3	CID000005572
Drug	dopexamine	DRD1 DRD5 ADCY1	5.32e-05	32	52	3	CID000055483
Drug	Depixol	DRD1 DRD5 ADCY1	5.84e-05	33	52	3	CID000017011
Drug	Adenosine triphosphate	ABCC8 ABCC9 ADCY1	5.84e-05	33	52	3	DB00171
Drug	chromanol 293B	KCND3 ABCC8 KCNQ1	5.84e-05	33	52	3	CID000121846
Drug	6,7-ADTN	DRD1 DRD5 ADCY1	5.84e-05	33	52	3	CID000003153
Drug	NSC759587	CACNA1C DRD1 DRD5 KCND2 GLRB APP KLHL17	6.42e-05	444	52	7	CID000003816
Drug	sulpiride	DRD1 DRD5 ABCC9 ADCY1	6.88e-05	96	52	4	CID000005355
Drug	Diltiazem	CACNA1C IL12A DRD1	6.98e-05	35	52	3	ctd:D004110
Drug	baclofen	CACNA1C DRD1 DRD5 GLRB ADCY1	7.44e-05	191	52	5	CID000002284
Drug	AC1L1DSZ	DRD1 DRD5 ADCY1	7.61e-05	36	52	3	CID000002494
Drug	C6H12NO5P	DRD1 DRD5 GLRB	7.61e-05	36	52	3	CID000104962
Drug	2'-ISP	DRD1 DRD5	7.63e-05	6	52	2	CID000128389
Drug	Rotigotine	DRD1 DRD5	7.63e-05	6	52	2	DB05271
Drug	pyrazole-3	DRD1 DRD5	7.63e-05	6	52	2	CID000354929
Drug	Zuclopenthixol	DRD1 DRD5	7.63e-05	6	52	2	DB01624
Drug	pergolide sulfone	DRD1 DRD5	7.63e-05	6	52	2	CID000155750
Drug	pergolide sulfoxide	DRD1 DRD5	7.63e-05	6	52	2	CID000155749
Disease	depressive disorder (implicated_via_orthology)	DRD1 DRD5 NOS1AP	6.48e-06	22	49	3	DOID:1596 (implicated_via_orthology)
Disease	Brugada Syndrome (disorder)	CACNA1C KCND3 ABCC9	8.50e-06	24	49	3	C1142166
Disease	Bipolar Disorder	CACNA1C DRD1 DRD5 MC2R BCHE APP SLC1A6	1.32e-05	477	49	7	C0005586
Disease	Hyperkinesia, Generalized	DRD1 BCHE ADCY1	2.06e-05	32	49	3	C0751217
Disease	Hyperkinesia	DRD1 BCHE ADCY1	2.06e-05	32	49	3	C3887506
Disease	familial long QT syndrome	KCNQ1 NOS1AP	2.69e-05	5	49	2	MONDO_0019171
Disease	Atrial fibrillation	KCNQ1 ABCC9	4.04e-05	6	49	2	cv:C0004238
Disease	Alzheimer's disease (is_marker_for)	DRD1 DRD5 SNAP91 BCHE APP	6.72e-05	257	49	5	DOID:10652 (is_marker_for)
Disease	Sudden Cardiac Arrest	KCND2 KCND3	7.52e-05	8	49	2	C1720824
Disease	CREB-binding protein measurement	BCHE C9	7.52e-05	8	49	2	EFO_0801502
Disease	Mental deterioration	CACNA1C APP	9.65e-05	9	49	2	C0234985
Disease	Todd Paralysis	BCHE APP	9.65e-05	9	49	2	C0234544
Disease	Mild cognitive disorder	CACNA1C APP	9.65e-05	9	49	2	C1270972
Disease	Paralysed	BCHE APP	9.65e-05	9	49	2	C0522224
Disease	Shortened QT interval	CACNA1C ABCC9	1.47e-04	11	49	2	C0151879
Disease	Manic Disorder	CACNA1C DRD1 DRD5	2.27e-04	71	49	3	C0024713
Disease	Impaired cognition	CACNA1C APP	2.43e-04	14	49	2	C0338656
Disease	T wave morphology measurement	KCNQ1 NOS1AP	2.43e-04	14	49	2	EFO_0008398
Disease	familial atrial fibrillation (is_implicated_in)	KCNQ1 ABCC9	2.43e-04	14	49	2	DOID:0050650 (is_implicated_in)
Disease	Manic	CACNA1C DRD1 DRD5	3.00e-04	78	49	3	C0338831
Disease	Depression, Bipolar	CACNA1C DRD1 DRD5	3.11e-04	79	49	3	C0005587
Disease	Romano-Ward Syndrome	KCNQ1 NOS1AP	3.19e-04	16	49	2	C0035828
Disease	Antibody Deficiency Syndrome	CACNA1C C9	3.62e-04	17	49	2	C0003257
Disease	Seizures	HEXB DRD1 BCHE APP	4.73e-04	218	49	4	C0036572
Disease	sciatic neuropathy (biomarker_via_orthology)	ABCC8 ABCC9 NOS1AP	6.03e-04	99	49	3	DOID:11446 (biomarker_via_orthology)
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	KCNQ1 ABCC9	6.11e-04	22	49	2	C1843687
Disease	Immunologic Deficiency Syndromes	CACNA1C C9	6.68e-04	23	49	2	C0021051
Disease	JT interval	KCND3 ABCC8 KCNQ1 NOS1AP	7.67e-04	248	49	4	EFO_0007885
Disease	Cardiac Arrhythmia	CACNA1C KCND3	7.91e-04	25	49	2	C0003811
Disease	glucose tolerance test	ABCC8 KCNQ1	9.23e-04	27	49	2	EFO_0004307
Disease	R-warfarin measurement	GALNTL6 CACNA1C MYO5B PLEKHG3	9.81e-04	265	49	4	EFO_0803324
Disease	body weight	GALNTL6 CACNA1C IPO9 KCND3 ABCC8 RTTN KCNQ1 DCST2	1.03e-03	1261	49	8	EFO_0004338
Disease	Depressive disorder	CACNA1C DRD1 DRD5 APP	1.35e-03	289	49	4	C0011581
Disease	Parkinsonism (biomarker_via_orthology)	ABCC8 ABCC9	1.46e-03	34	49	2	DOID:0080855 (biomarker_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C NOS1AP	1.64e-03	36	49	2	DOID:11723 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LARVERVIVVSMNYR	BCHE	161	P06276
IYSRIDRLEAFVRMV	BLOC1S4	131	Q9NUP1
IRSQVMTHLRVIYER	APP	526	P05067
MAVEINVIRVRRYVF	ABCC9	181	O60706
VLVAETTMARIRRVY	APMAP	271	Q9HDC9
IYKRFLTRMTRVSEF	SNAP91	236	O60641
PVAIMIVTYTRIYRI	DRD1	206	P21728
ADRSFTVAVYMLVVR	CFAP251	711	Q8TBY9
IPVAIMIVTYTRIYR	DRD5	236	P21918
VTEKVRRIMESYFRL	P3H1	541	Q32P28
RYRFIRSVMSIIDVV	KCND3	251	Q9UK17
RATIKVIRRMQYFVA	KCNQ1	511	P51787
VLRRVSHRYIVQLME	PSKH2	111	Q96QS6
TRIFFYVRRRVQRMA	LPAR2	206	Q9HBW0
VLSRMLVRLTEVDVY	GREB1	1361	Q4ZG55
RYMRETRSQLSVFEV	MCM3AP	646	O60318
ERLMVRIGVFSVLYT	FZD2	456	Q14332
APSRYRFVRSVMSII	KCND2	251	Q9NZV8
VEVIFTLRRQVGFYM	GLRB	256	P48167
AFRIRAVTIDRVMSY	IL12A	201	P29459
ARMYRDDITIIVVQF	PDP1	511	Q9P0J1
MYGVFVRILTERSQR	ADCY1	226	Q08828
VAAMSTRRRYVRVAT	KLHL17	466	Q6TDP4
ISITFFRLFRVMRLV	CACNA1C	1371	Q13936
VRRFRVLILMVFLVA	FAM20C	6	Q8IXL6
QYSTRVVTRTMVRTE	SLC1A6	201	P48664
IFTMAEVYGIRTRSR	IPO9	196	Q96P70
NIYITSRFLRMEAVR	DCST2	356	Q5T1A1
NSRVEIVAAMRRIRY	NOS1AP	46	O75052
VRMVIEYARLRGIRV	HEXB	271	P07686
FVMRNRDVVLTTTFV	C9	306	P02748
LVYFVVRTVRMRRRN	FAM174A	136	Q8TBP5
IIFSYLRIMVTVLRI	OR1L6	251	Q8NGR2
LEEYMARFSKVRIVR	GALNTL6	191	Q49A17
REVRAAVTRMSFYLL	RTTN	1086	Q86VV8
MLTLTRIRTVSYEVR	TAS2R38	1	P59533
EAVRMVRVLTVLREY	USP9X	846	Q93008
RDVYEEAIRTVMTVR	XAB2	276	Q9HCS7
RFTTYEVRMRTNLPI	SNX12	46	Q9UMY4
RVVREIVETERMYVQ	PLEKHG3	96	A1L390
LIYISIMYREVITQR	RNF170	241	Q96K19
VSMIRDIREREIRIY	POLR2B	601	P30876
RVTRRFIVVEGLYMN	SPTLC1	236	O15269
MLLLVEVNVIRVRRY	ABCC8	181	Q09428
LRYHSIVTMRRTVVV	MC2R	136	Q01718
ERIRVTSERVTEMYF	TRPM6	1171	Q9BX84
VRERIGSVLTYIFMI	PSME4	1501	Q14997
STDVVAFILRQVMRY	PITPNM3	581	Q9BZ71
VMVILRTVYRRDVQS	UBR3	866	Q6ZT12
FVRVRSYESQMVIRP	STARD7	261	Q9NQZ5
RLTRMYNVRIMRVEF	TFR2	701	Q9UP52
VIQAFTRAMFVRRTY	MYO5B	841	Q9ULV0
TRAMFVRRTYRQVLM	MYO5B	846	Q9ULV0