Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

AGAP5 ABR TBC1D2B AGAP11 RABEP1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

8.41e-0627912210GO:0005096
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP8B3 ABCA1 ATP8A1

1.82e-0591223GO:0090556
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ATP8B3 MYH3 AGAP5 ABCA1 AGAP11 RFC3 KIF20B ATP8A1 ATAD3A MACF1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

7.73e-0577512215GO:0017111
GeneOntologyMolecularFunctionactin filament binding

MYH2 MYH3 MYH6 SYNE1 CORO1A KBTBD13 MACF1 PLEC

7.81e-052271228GO:0051015
GeneOntologyMolecularFunctioncoreceptor activity

ITGA4 LRP1 LRP6 LRP5 KDR

7.91e-05721225GO:0015026
GeneOntologyMolecularFunctioncalmodulin binding

MYH2 MYH3 MYH6 MAP6D1 ACE RYR1 RYR2 KCNH5

8.56e-052301228GO:0005516
GeneOntologyMolecularFunctionATP-dependent activity

ATP8B3 MYH2 MYH3 MYH6 ABCA1 RFC3 KIF20B ATP8A1 ATAD3A KCNJ8 MACF1 ATP4B KIF11

9.88e-0561412213GO:0140657
GeneOntologyMolecularFunctionapolipoprotein receptor activity

ABCA1 LRP1

1.11e-0431222GO:0030226
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1B LRP1 LRP6

1.18e-04161223GO:0005041
GeneOntologyMolecularFunctionfloppase activity

ATP8B3 ABCA1 ATP8A1

1.18e-04161223GO:0140328
GeneOntologyMolecularFunctionactin binding

MYH2 MYH3 MYH6 SYNE1 ACE PXK CORO1A DST KBTBD13 MACF1 PLEC

1.73e-0447912211GO:0003779
GeneOntologyMolecularFunctionpyrophosphatase activity

ATP8B3 MYH3 AGAP5 ABCA1 AGAP11 RFC3 KIF20B ATP8A1 ATAD3A MACF1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.85e-0483912215GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ATP8B3 MYH3 AGAP5 ABCA1 AGAP11 RFC3 KIF20B ATP8A1 ATAD3A MACF1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.87e-0484012215GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ATP8B3 MYH3 AGAP5 ABCA1 AGAP11 RFC3 KIF20B ATP8A1 ATAD3A MACF1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.87e-0484012215GO:0016818
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

2.20e-0441222GO:0005219
GeneOntologyMolecularFunctionapolipoprotein binding

ABCA1 LRP1 LRP6

2.35e-04201223GO:0034185
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1B LRP1 LRP6

2.73e-04211223GO:0030228
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

AGAP5 ABR KALRN TBC1D2B AGAP11 RABEP1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.82e-0450712211GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

AGAP5 ABR KALRN TBC1D2B AGAP11 RABEP1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.82e-0450712211GO:0030695
GeneOntologyMolecularFunctionserine hydrolase activity

AADAC CELA2A CELA2B ACE F12 PRSS36 ADAM17

3.29e-042121227GO:0017171
GeneOntologyMolecularFunctionphospholipid binding

AGAP5 ABCA1 AGAP11 CERT1 PXK CPNE3 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

5.42e-0454812211GO:0005543
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

5.47e-0461222GO:0048763
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP8B3 ABCA1 ATP8A1

6.52e-04281223GO:0140326
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYH2 MYH3 MYH6 KIF20B KIF11

7.91e-041181225GO:0003774
GeneOntologyMolecularFunctionmetalloexopeptidase activity

NPEPPS CPZ ACE ADAM17

8.91e-04701224GO:0008235
GeneOntologyMolecularFunctionphospholipid transporter activity

ATP8B3 ABCA1 CERT1 ATP8A1

1.10e-03741224GO:0005548
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH2 MYH3 MYH6

1.61e-03381223GO:0000146
GeneOntologyMolecularFunctionmetallodipeptidase activity

ACE ADAM17

1.61e-03101222GO:0070573
GeneOntologyMolecularFunctionserine-type peptidase activity

CELA2A CELA2B ACE F12 PRSS36 ADAM17

1.72e-032071226GO:0008236
GeneOntologyMolecularFunctioncargo receptor activity

ABCA1 LRP1B LRP1 LRP6

1.83e-03851224GO:0038024
GeneOntologyMolecularFunctioncalcium ion binding

PCDHGC5 LRP1B FSCB F12 PCDH20 RYR1 RYR2 TGM3 THBS3 DST LRP1 MACF1

2.13e-0374912212GO:0005509
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A8 RYR1 RYR2 KCNJ8 SLC38A7 TRPM1 NALF2 ATP4B KCNH5

2.23e-034651229GO:0046873
GeneOntologyMolecularFunctiontoxin transmembrane transporter activity

LRP6 LRP5

2.35e-03121222GO:0019534
GeneOntologyMolecularFunctioncytoskeletal protein binding

MYH2 MYH3 MYH6 SYNM SYNE1 MAP6D1 ACE KIF20B PXK CORO1A DST KBTBD13 MACF1 PLEC KIF11

2.88e-03109912215GO:0008092
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP8B3 ABCA1 ATP8A1

3.74e-03511223GO:0140303
GeneOntologyBiologicalProcessactivation of GTPase activity

AGAP5 ABR TBC1D2B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.71e-081091229GO:0090630
GeneOntologyBiologicalProcessimport into cell

ANKRD13B ABCA1 ABR SYNE1 TBC1D2B SLC12A8 ITGA4 LRP1B CORO1A ATP8A1 GRK3 RABEP1 KCNJ8 TLR4 LRP1 LRP6 LRP5 TRPM1 LY75 NALF2 ATP4B

1.24e-06107412221GO:0098657
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

AGAP5 ABR KALRN TBC1D2B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.93e-0624412210GO:0043547
GeneOntologyBiologicalProcessendocytosis

ANKRD13B ABCA1 ABR SYNE1 TBC1D2B ITGA4 LRP1B CORO1A ATP8A1 GRK3 RABEP1 TLR4 LRP1 LRP6 LRP5 LY75

2.99e-0582712216GO:0006897
GeneOntologyBiologicalProcessregulation of GTPase activity

AGAP5 ABR KALRN TBC1D2B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.08e-0533512210GO:0043087
GeneOntologyBiologicalProcessheart development

MYH6 SYNE1 ITGA4 ACVRL1 ACE CERT1 RYR1 RYR2 FREM2 KCNJ8 LRP1 LRP6 KDR PLEC CPLANE1

4.12e-0575712215GO:0007507
GeneOntologyBiologicalProcesscell-substrate junction assembly

ACVRL1 DST LRP1 MACF1 KDR PLEC

4.43e-051081226GO:0007044
GeneOntologyBiologicalProcesspositive regulation of mesenchymal cell proliferation

SYNE1 LRP6 LRP5 KDR

5.93e-05361224GO:0002053
GeneOntologyBiologicalProcesscell-substrate junction organization

ACVRL1 DST LRP1 MACF1 KDR PLEC

6.30e-051151226GO:0150115
GeneOntologyBiologicalProcessmuscle filament sliding

MYH2 MYH3 MYH6

8.72e-05151223GO:0030049
GeneOntologyBiologicalProcessmuscle contraction

MYH2 MYH3 MYH6 SYNM CERT1 RYR1 RYR2 ADRA2C KCNJ8 KBTBD13

1.35e-0440012210GO:0006936
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

SYNE1 LRP6 LRP5 KDR

1.44e-04451224GO:0010464
GeneOntologyBiologicalProcessresponse to wounding

MYH2 CELA2A ACVRL1 F8 F12 ADRA2C DST TLR4 LRP1 MACF1 KDR ADAM17 PLEC

1.45e-0465912213GO:0009611
GeneOntologyBiologicalProcessactin-myosin filament sliding

MYH2 MYH3 MYH6

1.54e-04181223GO:0033275
GeneOntologyBiologicalProcessblood vessel remodeling

ABR ITGA4 ACVRL1 ACE LRP1

1.67e-04871225GO:0001974
GeneOntologyBiologicalProcesswound healing

MYH2 CELA2A ACVRL1 F8 F12 ADRA2C DST TLR4 MACF1 KDR PLEC

1.68e-0449312211GO:0042060
GeneOntologyBiologicalProcesscellular response to high density lipoprotein particle stimulus

ABCA1 ADAM17

2.07e-0441222GO:0071403
GeneOntologyBiologicalProcessvascular process in circulatory system

ABR ITGA4 ACE ADRA2C ATP8A1 KCNJ8 LRP1 KDR PLEC

2.10e-043441229GO:0003018
GeneOntologyBiologicalProcesspeptidyl-cysteine modification

OXR1 MAP6D1 ZDHHC17 ACE

2.17e-04501224GO:0018198
GeneOntologyBiologicalProcesspositive regulation of molecular function

AGAP5 ABR KALRN TBC1D2B AGAP11 RFC3 RYR2 ADRA2C TLR4 LRP1 LRP6 LRP5 KDR ADAM17 AGAP9 AGAP7P PPP2R3C AGAP4 AGAP6 AGAP1

2.68e-04143012220GO:0044093
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT5 SYNM DST MACF1 PLEC

3.06e-04991225GO:0045104
GeneOntologyBiologicalProcessstriated muscle contraction

MYH3 MYH6 SYNM RYR1 RYR2 KCNJ8 KBTBD13

3.12e-042171227GO:0006941
GeneOntologyBiologicalProcessintermediate filament-based process

KRT5 SYNM DST MACF1 PLEC

3.21e-041001225GO:0045103
GeneOntologyBiologicalProcessNorrin signaling pathway

LRP6 LRP5

3.43e-0451222GO:0110135
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

AGAP5 ABR KALRN TBC1D2B AGAP11 RFC3 ADRA2C TLR4 KDR ADAM17 AGAP9 AGAP7P PPP2R3C AGAP4 AGAP6 AGAP1

3.70e-04102812216GO:0043085
GeneOntologyBiologicalProcesscirculatory system process

MYH6 ABR ITGA4 ACVRL1 ACE RYR2 ADRA2C ATP8A1 KCNJ8 LRP1 LRP5 KDR PLEC

4.05e-0473312213GO:0003013
GeneOntologyBiologicalProcessmuscle system process

MYH2 MYH3 MYH6 SYNM CAMTA2 CERT1 RYR1 RYR2 ADRA2C KCNJ8 KBTBD13

4.08e-0454712211GO:0003012
GeneOntologyBiologicalProcessmesenchymal cell proliferation

SYNE1 LRP6 LRP5 KDR

4.12e-04591224GO:0010463
GeneOntologyCellularComponentmyofibril

MYH2 MYH3 MYH6 SYNM SYNE1 RYR1 RYR2 DST GRK3 KCNJ8 KBTBD13 PLEC

7.02e-0827312212GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

MYH2 MYH3 MYH6 SYNM SYNE1 RYR1 RYR2 DST GRK3 KCNJ8 KBTBD13 PLEC

1.35e-0729012212GO:0043292
GeneOntologyCellularComponentsarcomere

MYH2 MYH3 MYH6 SYNM SYNE1 RYR1 RYR2 DST GRK3 KBTBD13 PLEC

2.41e-0724912211GO:0030017
GeneOntologyCellularComponentZ disc

MYH6 SYNM RYR1 RYR2 DST GRK3 KBTBD13 PLEC

2.96e-061511228GO:0030018
GeneOntologyCellularComponentI band

MYH6 SYNM RYR1 RYR2 DST GRK3 KBTBD13 PLEC

5.97e-061661228GO:0031674
GeneOntologyCellularComponentsupramolecular fiber

MYH2 KRT5 MYH3 MYH6 SYNM SYNE1 MAP6D1 KEAP1 KIF20B RYR1 RYR2 CORO1A DST GRK3 KCNJ8 KBTBD13 MACF1 PLEC KIF11

5.24e-05117912219GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

MYH2 KRT5 MYH3 MYH6 SYNM SYNE1 MAP6D1 KEAP1 KIF20B RYR1 RYR2 CORO1A DST GRK3 KCNJ8 KBTBD13 MACF1 PLEC KIF11

5.73e-05118712219GO:0099081
GeneOntologyCellularComponentmuscle myosin complex

MYH2 MYH3 MYH6

1.03e-04161223GO:0005859
GeneOntologyCellularComponentearly endosome

ANKRD13B TBC1D2B LAMP5 PXK HAVCR2 CORO1A RABEP1 TLR4 LRP1 LRP6 KDR

1.21e-0448112211GO:0005769
GeneOntologyCellularComponentkeratohyalin granule

CELA2A CELA2B

3.34e-0451222GO:0036457
GeneOntologyCellularComponentWnt-Frizzled-LRP5/6 complex

LRP6 LRP5

3.34e-0451222GO:1990851
GeneOntologyCellularComponentperinuclear region of cytoplasm

ANKRD13B ABCA1 KALRN SYNE1 CERT1 KIF20B RYR1 THBS3 DST GRK3 TLR4 LRP1 ATXN10 PLEC WWC1

3.58e-0493412215GO:0048471
GeneOntologyCellularComponentmyosin filament

MYH2 MYH3 MYH6

4.06e-04251223GO:0032982
GeneOntologyCellularComponentmyosin II complex

MYH2 MYH3 MYH6

5.71e-04281223GO:0016460
GeneOntologyCellularComponentsomatodendritic compartment

ABR KALRN SYNE1 NFASC LAMP5 ITGA4 ACVRL1 GPR179 ADRA2C GRK3 LRP1 SLC38A7 LRP6 KDR TRPM1 ATXN10 PLEC

7.81e-04122812217GO:0036477
GeneOntologyCellularComponentsarcolemma

SYNM RYR1 RYR2 DST KCNJ8 PLEC

8.80e-041901226GO:0042383
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

1.47e-03101222GO:0014701
GeneOntologyCellularComponentCul3-RING ubiquitin ligase complex

KEAP1 KBTBD7 KLHL12

1.52e-03391223GO:0031463
GeneOntologyCellularComponenthemidesmosome

DST PLEC

1.80e-03111222GO:0030056
GeneOntologyCellularComponentaxon

ABR NFASC LAMP5 ITGA4 KIF20B CORO1A ADRA2C DST GRK3 LRP1 SLC38A7 TRPM1 PLEC

2.12e-0389112213GO:0030424
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP8B3 ATP8A1

2.94e-03141222GO:1990531
GeneOntologyCellularComponentcontractile ring

MYH2 KIF20B

2.94e-03141222GO:0070938
MousePhenofused cornea and lens

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.10e-1024987MP:0001307
MousePhenoabnormal lens development

AGAP5 AGAP11 ADAM17 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.84e-0878988MP:0005545
MousePhenoabnormal anterior uvea morphology

AGAP5 KERA AGAP11 FREM2 ADAM17 TRPM1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.40e-071999811MP:0005194
MousePhenoabnormal eye development

AGAP5 AGAP11 CERT1 FREM2 DST TLR4 LRP6 LRP5 MACF1 ADAM17 KLHL12 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.18e-074829816MP:0001286
MousePhenoabnormal iris morphology

AGAP5 AGAP11 FREM2 ADAM17 TRPM1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

9.29e-071929810MP:0001322
MousePhenoabnormal uvea morphology

AGAP5 KERA AGAP11 FREM2 ADAM17 TRPM1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

9.53e-072419811MP:0005197
MousePhenoincreased circulating potassium level

AGAP5 AGAP11 RYR1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.05e-06121988MP:0005627
MousePhenoabsent pinna reflex

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.89e-0689987MP:0006358
MousePhenopersistence of hyaloid vascular system

AGAP5 AGAP11 DST LRP5 KLHL12 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.59e-062239810MP:0001289
MousePhenoabnormal pinna reflex

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.73e-06101987MP:0001485
MousePhenoabnormal potassium level

AGAP5 AGAP11 ACE RYR1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

9.35e-06196989MP:0020887
MousePhenoabnormal potassium ion homeostasis

AGAP5 AGAP11 ACE RYR1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.02e-05198989MP:0011978
MousePhenocornea opacity

AGAP5 AGAP11 ADAM17 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.55e-05159988MP:0001314
MousePhenoabnormal muscle fiber morphology

MYH3 MYH6 KALRN SYNM SYNE1 RYR1 RYR2 DST KCNJ8 KBTBD13 ADAM17 PLEC

2.61e-054069812MP:0004087
MousePhenoabnormal circulating potassium level

AGAP5 AGAP11 RYR1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.63e-05171988MP:0002668
MousePhenoabnormal skin coloration

AGAP5 AGAP11 DST AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

4.11e-05182988MP:0011239
MousePhenoabnormal cardiac output

MYH6 SYNM CELA2A CELA2B KCNJ8

4.40e-0556985MP:0001627
MousePhenoabnormal vitreous body morphology

AGAP5 AGAP11 DST SATB1 LRP5 KLHL12 AGAP9 AGAP7P MAPK6 AGAP4 AGAP6 AGAP1

4.47e-054299812MP:0002699
MousePhenodecreased cardiac stroke volume

MYH6 SYNM CELA2A CELA2B

5.41e-0530984MP:0011952
MousePhenoabnormal craniofacial morphology

KRT5 AGAP5 ATR NPEPPS AGAP11 ITGA4 ACVRL1 CERT1 KIF20B RYR1 FREM2 DST LRP1 LRP6 LRP5 KDR AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 PCM1 AGAP1

5.75e-0513729823MP:0000428
MousePhenocraniofacial phenotype

KRT5 AGAP5 ATR NPEPPS AGAP11 ITGA4 ACVRL1 CERT1 KIF20B RYR1 FREM2 DST LRP1 LRP6 LRP5 KDR AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 PCM1 AGAP1

5.75e-0513729823MP:0005382
MousePhenoabnormal mouth morphology

KRT5 AGAP5 ATR NPEPPS AGAP11 KIF20B RYR1 DST LRP6 AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 AGAP1

6.22e-056709815MP:0000452
MousePhenoabnormal tooth morphology

AGAP5 ATR NPEPPS AGAP11 LRP6 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

7.68e-053189810MP:0002100
MousePhenoabnormal dental arch morphology

AGAP5 ATR NPEPPS AGAP11 LRP6 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

7.88e-053199810MP:0030254
MousePhenodecreased cardiac output

MYH6 SYNM CELA2A CELA2B

1.26e-0437984MP:0003393
MousePhenoabnormal facial morphology

KRT5 AGAP5 ATR NPEPPS AGAP11 CERT1 KIF20B RYR1 FREM2 DST LRP6 AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 AGAP1

1.79e-049109817MP:0003743
MousePhenoabnormal heart left ventricle size

MYH6 ABCA1 SYNM CELA2A CELA2B RYR2 ADAM17

1.83e-04169987MP:0010578
MousePhenoabnormal heart ventricle size

MYH6 ABCA1 SYNM CELA2A CELA2B CERT1 RYR2 ADAM17

1.98e-04228988MP:0031543
MousePhenoabnormal lung size

ATR SYNE1 TLR4 ADGRF5 ADAM17 MAPK6 CPLANE1

2.19e-04174987MP:0004881
MousePhenoabnormal cornea morphology

AGAP5 KERA AGAP11 FREM2 ADAM17 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.42e-043669810MP:0001312
MousePhenoabnormal head morphology

KRT5 AGAP5 ATR NPEPPS AGAP11 ACVRL1 CERT1 KIF20B BRWD3 RYR1 FREM2 DST LRP6 AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 AGAP1

2.48e-0411209819MP:0000432
MousePhenodecreased circulating angiotensin II level

ACVRL1 ACE

2.89e-044982MP:0031231
MousePhenodecreased angiotensin II level

ACVRL1 ACE

2.89e-044982MP:0031228
MousePhenoabnormal heart echocardiography feature

MYH6 SYNM RYR2 KCNJ8

3.78e-0449984MP:0011925
MousePhenoabnormal snout morphology

AGAP5 AGAP11 FREM2 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

4.42e-04257988MP:0000443
MousePhenoabnormal cardiac stroke volume

MYH6 SYNM CELA2A CELA2B

4.75e-0452984MP:0000304
MousePhenoincreased myocardial fiber size

MYH6 SYNM KCNJ8 ADAM17

5.11e-0453984MP:0004564
MousePhenoabnormal cranium morphology

AGAP5 ATR NPEPPS AGAP11 RYR1 FREM2 LRP6 LRP5 AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 PCM1 AGAP1

5.12e-048139815MP:0000438
MousePhenoabnormal reflex

AGAP5 ABCA1 KALRN AGAP11 RYR1 RYR2 ADRA2C DST SATB1 TLR4 TRPM1 AGAP9 AGAP7P MAPK6 AGAP4 AGAP6 PCM1 SENP7 AGAP1 KCNH5

5.63e-0412949820MP:0001961
MousePhenoabnormal muscle morphology

MYH3 MYH6 ABCA1 KALRN SYNM SYNE1 ACVRL1 CERT1 RYR1 RYR2 PPP1R3A FREM2 DST KCNJ8 LRP1 KBTBD13 ADAM17 PLEC

6.09e-0411069818MP:0002108
MousePhenoabnormal craniofacial bone morphology

AGAP5 ATR NPEPPS AGAP11 RYR1 FREM2 LRP6 LRP5 AGAP9 AGAP7P CPLANE1 AGAP4 AGAP6 PCM1 AGAP1

6.12e-048279815MP:0002116
MousePhenoabnormal skeletal muscle fiber morphology

MYH3 SYNM SYNE1 RYR1 DST KBTBD13 PLEC

7.20e-04212987MP:0003084
MousePhenoabnormal blood circulation

MYH6 ABCA1 SYNM CELA2A CELA2B ITGA4 ACVRL1 CERT1 FREM2 KCNJ8 TLR4 LRP1 LRP5 ADAM17 PLEC

7.64e-048459815MP:0002128
MousePhenoabnormal heart right ventricle morphology

ABCA1 CELA2A CELA2B RYR2 ADAM17 CPLANE1

7.93e-04156986MP:0003920
MousePhenoabnormal muscle physiology

MYH6 ABCA1 SYNM SYNE1 PEX7 ACVRL1 CERT1 RYR1 RYR2 PPP1R3A DST KCNJ8 TLR4 KBTBD13 ADAM17 PLEC

9.25e-049549816MP:0002106
MousePhenoabnormal retina development

TLR4 LRP5 MACF1

9.64e-0428983MP:0009772
MousePhenoabnormal leukocyte migration

SPHK2 ITGA4 CORO1A TLR4 ADAM17 PLEC

9.66e-04162986MP:0003156
MousePhenoabnormal skin morphology

KRT5 AGAP5 ATR AGAP11 KEAP1 DDB2 PXK RYR1 TGM3 FREM2 DST SLC38A7 LRP6 ADAM17 PLEC AGAP9 AGAP7P AGAP4 AGAP6 PCM1 AGAP1

9.81e-0414559821MP:0002060
MousePhenosmall tail bud

BRWD3 LRP6

9.98e-047982MP:0012062
MousePhenoabnormal sympathetic nervous system physiology

CELA2A CELA2B ACVRL1

1.07e-0329983MP:0004183
MousePhenodecreased brain size

ATR ZDHHC17 KIF20B DST LRP6 MAPK6 CPLANE1 PCM1

1.09e-03295988MP:0000774
MousePhenoheart left ventricle hypertrophy

MYH6 ABCA1 SYNM RYR2

1.11e-0365984MP:0002625
DomainArfGap

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

5.91e-10291227SM00105
DomainARFGAP

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

5.91e-10291227PS50115
DomainArfGap

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

5.91e-10291227PF01412
DomainArfGAP

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

5.91e-10291227IPR001164
DomainKelch

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD13 KLHL12 KLHL26

9.73e-08581227SM00612
DomainBACK

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KLHL12 KLHL26

1.24e-07601227SM00875
DomainBACK

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KLHL12 KLHL26

1.39e-07611227IPR011705
DomainBACK

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KLHL12 KLHL26

1.39e-07611227PF07707
DomainPH

AGAP5 ABR KALRN TBC1D2B AGAP11 CERT1 GRK3 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.83e-0727812212SM00233
DomainPH_DOMAIN

AGAP5 ABR KALRN TBC1D2B AGAP11 CERT1 GRK3 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.94e-0727912212PS50003
DomainPH_domain

AGAP5 ABR KALRN TBC1D2B AGAP11 CERT1 GRK3 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.06e-0728012212IPR001849
DomainKelch_1

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD13 KLHL12 KLHL26

3.64e-07701227PF01344
DomainKelch_1

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD13 KLHL12 KLHL26

3.64e-07701227IPR006652
DomainSpectrin_repeat

KALRN SYNE1 DST MACF1 PLEC

1.15e-06291225IPR002017
DomainKelch-typ_b-propeller

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13

1.53e-06551226IPR015915
DomainLdl_recept_b

LRP1B LRP1 LRP6 LRP5

1.65e-06141224PF00058
DomainLDLRB

LRP1B LRP1 LRP6 LRP5

1.65e-06141224PS51120
DomainSPEC

KALRN SYNE1 DST MACF1 PLEC

1.91e-06321225SM00150
DomainSpectrin/alpha-actinin

KALRN SYNE1 DST MACF1 PLEC

1.91e-06321225IPR018159
DomainLY

LRP1B LRP1 LRP6 LRP5

2.24e-06151224SM00135
DomainLDLR_classB_rpt

LRP1B LRP1 LRP6 LRP5

2.24e-06151224IPR000033
DomainBTB

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13 KLHL12 KLHL26

2.33e-061311228PF00651
DomainGal_Oxase/kelch_b-propeller

KBTBD3 KEAP1 KBTBD7 KLHL11 KLHL12 KLHL26

2.33e-06591226IPR011043
Domain-

DST MACF1 PLEC

5.36e-06612233.90.1290.10
DomainAnkyrin_rpt-contain_dom

ANKRD13B AGAP5 CAMTA2 AGAP11 ZDHHC17 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.58e-0625412210IPR020683
DomainANK_REP_REGION

ANKRD13B AGAP5 CAMTA2 AGAP11 ZDHHC17 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.58e-0625412210PS50297
DomainBTB-kelch_protein

KBTBD3 KEAP1 KBTBD7 KLHL12 KLHL26

8.64e-06431225IPR017096
DomainPlectin

DST MACF1 PLEC

9.34e-0671223PF00681
DomainPlectin_repeat

DST MACF1 PLEC

9.34e-0671223IPR001101
DomainPLEC

DST MACF1 PLEC

9.34e-0671223SM00250
DomainBTB

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13 KLHL12 KLHL26

1.03e-051601228PS50097
DomainSpectrin

KALRN SYNE1 DST MACF1

1.39e-05231224PF00435
DomainACTININ_2

SYNE1 DST MACF1 PLEC

1.39e-05231224PS00020
DomainACTININ_1

SYNE1 DST MACF1 PLEC

1.39e-05231224PS00019
DomainActinin_actin-bd_CS

SYNE1 DST MACF1 PLEC

1.39e-05231224IPR001589
Domain-

KBTBD3 KBTBD7 KLHL11 KBTBD4 KBTBD13

1.50e-054812252.120.10.80
DomainPH

ABR KALRN TBC1D2B AGAP11 CERT1 GRK3 AGAP7P AGAP4 AGAP1

1.97e-052291229PF00169
DomainPH_dom-like

AGAP5 ABR KALRN TBC1D2B AGAP11 CERT1 GRK3 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.29e-0542612212IPR011993
DomainBTB

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13 KLHL12 KLHL26

2.41e-051801228SM00225
DomainBTB/POZ_dom

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13 KLHL12 KLHL26

2.93e-051851228IPR000210
DomainSKP1/BTB/POZ

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13 KLHL12 KLHL26

3.41e-051891228IPR011333
Domain-

ANKRD13B AGAP5 CAMTA2 AGAP11 ZDHHC17 AGAP9 AGAP4 AGAP6 AGAP1

3.68e-0524812291.25.40.20
DomainDUF5050

LRP1B LRP1

4.23e-0521222IPR032485
DomainLRP5/6

LRP6 LRP5

4.23e-0521222IPR017049
DomainDUF5050

LRP1B LRP1

4.23e-0521222PF16472
DomainANK_REPEAT

ANKRD13B AGAP5 CAMTA2 AGAP11 ZDHHC17 AGAP7P AGAP4 AGAP6 AGAP1

4.29e-052531229PS50088
Domain-

AGAP5 ABR KALRN TBC1D2B AGAP11 CERT1 GRK3 AGAP9 AGAP4 AGAP6 AGAP1

5.17e-05391122112.30.29.30
DomainAnkyrin_rpt

ANKRD13B AGAP5 CAMTA2 AGAP11 ZDHHC17 AGAP7P AGAP4 AGAP6 AGAP1

5.63e-052621229IPR002110
DomainGal_Oxidase_b-propeller

KEAP1 KLHL11 KLHL12 KLHL26

6.91e-05341224IPR015916
DomainMyosin_N

MYH2 MYH3 MYH6

1.17e-04151223PF02736
DomainMyosin_N

MYH2 MYH3 MYH6

1.17e-04151223IPR004009
Domain-

LRP1B LRP1 LRP6 LRP5

1.19e-043912242.120.10.30
DomainRyanodine_rcpt

RYR1 RYR2

1.26e-0431222IPR003032
DomainRyanrecept_TM4-6

RYR1 RYR2

1.26e-0431222IPR009460
DomainRyR

RYR1 RYR2

1.26e-0431222PF02026
DomainRR_TM4-6

RYR1 RYR2

1.26e-0431222PF06459
DomainRyan_recept

RYR1 RYR2

1.26e-0431222IPR013333
DomainLDLR_class-A_CS

LRP1B LRP1 LRP6 LRP5

1.32e-04401224IPR023415
DomainMyosin_tail_1

MYH2 MYH3 MYH6

2.07e-04181223PF01576
DomainMyosin_tail

MYH2 MYH3 MYH6

2.07e-04181223IPR002928
DomainLdl_recept_a

LRP1B LRP1 LRP6 LRP5

2.10e-04451224PF00057
Domain6-blade_b-propeller_TolB-like

LRP1B LRP1 LRP6 LRP5

2.29e-04461224IPR011042
Domain-

LRP1B LRP1 LRP6 LRP5

2.29e-044612244.10.400.10
DomainMyosin-like_IQ_dom

MYH2 MYH3 MYH6

2.44e-04191223IPR027401
Domain-

MYH2 MYH3 MYH6

2.44e-041912234.10.270.10
DomainANK

ANKRD13B AGAP5 AGAP11 ZDHHC17 AGAP7P AGAP4 AGAP6 AGAP1

2.45e-042511228SM00248
DomainLDLRA_1

LRP1B LRP1 LRP6 LRP5

2.70e-04481224PS01209
DomainLDrepeatLR_classA_rpt

LRP1B LRP1 LRP6 LRP5

2.93e-04491224IPR002172
DomainLDLa

LRP1B LRP1 LRP6 LRP5

2.93e-04491224SM00192
DomainLDLRA_2

LRP1B LRP1 LRP6 LRP5

2.93e-04491224PS50068
DomainAnk_2

ANKRD13B AGAP5 AGAP11 ZDHHC17 AGAP4 AGAP6 AGAP1

5.32e-042151227PF12796
DomainRIH_assoc-dom

RYR1 RYR2

6.24e-0461222IPR013662
DomainGAR

DST MACF1

6.24e-0461222PS51460
DomainIns145_P3_rec

RYR1 RYR2

6.24e-0461222PF08709
DomainGAS2

DST MACF1

6.24e-0461222PF02187
DomainRIH_assoc

RYR1 RYR2

6.24e-0461222PF08454
DomainRIH_dom

RYR1 RYR2

6.24e-0461222IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2

6.24e-0461222IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2

6.24e-0461222IPR015925
Domain-

RYR1 RYR2

6.24e-04612221.25.10.30
Domain-

DST MACF1

6.24e-04612223.30.920.20
DomainRYDR_ITPR

RYR1 RYR2

6.24e-0461222PF01365
DomainGAS_dom

DST MACF1

6.24e-0461222IPR003108
DomainGAS2

DST MACF1

6.24e-0461222SM00243
Domain-

KEAP1 KLHL12 KLHL26

7.09e-042712232.130.10.80
DomainAnk

ANKRD13B CAMTA2 AGAP11 ZDHHC17 AGAP7P AGAP4 AGAP1

7.52e-042281227PF00023
DomainCH

SYNE1 DST MACF1 PLEC

8.63e-04651224SM00033
DomainEGF

LRP1B F12 GPR179 THBS3 LRP1 LRP6 LRP5

8.98e-042351227SM00181
DomainCH

SYNE1 DST MACF1 PLEC

1.14e-03701224PF00307
DomainIQ

MYH2 MYH3 MYH6 CAMTA2

1.20e-03711224PF00612
Domain-

SYNE1 DST MACF1 PLEC

1.20e-037112241.10.418.10
DomainEGF-like_Ca-bd_dom

LRP1B F12 THBS3 LRP1 LRP5

1.33e-031241225IPR001881
DomainCH

SYNE1 DST MACF1 PLEC

1.33e-03731224PS50021
DomainEGF

LRP1B F12 LRP1 LRP6 LRP5

1.43e-031261225PF00008
DomainCH-domain

SYNE1 DST MACF1 PLEC

1.47e-03751224IPR001715
DomainEGF-like_CS

LRP1B F12 THBS3 LRP1 LRP6 LRP5 ADAM17

1.64e-032611227IPR013032
DomainMIR

RYR1 RYR2

1.84e-03101222PF02815
DomainMIR_motif

RYR1 RYR2

1.84e-03101222IPR016093
DomainMIR

RYR1 RYR2

1.84e-03101222PS50919
DomainMIR

RYR1 RYR2

1.84e-03101222SM00472
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

KRT5 DST PLEC

2.06e-059903MM15117
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

KRT5 DST PLEC

4.00e-0511903M27372
Pubmed

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

2.08e-169123712640130
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.92e-1610123720664521
Pubmed

AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.90e-1511123715381706
Pubmed

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

9.81e-1513123727713690
Pubmed

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.96e-1414123722453919
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

AGAP5 KALRN AGAP11 CORO1A AGAP9 AGAP7P AGAP4 AGAP6 PCM1 WWC1 AGAP1

3.80e-102181231133378226
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

AGAP5 KALRN SYNE1 AGAP11 GRK3 ATAD3A MACF1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.97e-102811231228706196
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1B LRP1 LRP6 LRP5

4.82e-0811123424639464
Pubmed

The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.

KRT5 LRP6 LRP5

4.29e-075123319672307
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

AGAP5 NPEPPS AGAP11 RABEP1 SLC38A7 TTI1 AGAP9 AGAP7P AGAP4 AGAP6 WWC1 AGAP1

4.85e-075361231215840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

AGAP5 NPEPPS AGAP11 RABEP1 SLC38A7 TTI1 AGAP9 AGAP7P AGAP4 AGAP6 WWC1 AGAP1

5.05e-075381231210512203
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

OXR1 KALRN KDM5A SYNM SYNE1 MRPS35 LRP1B BRWD3 DST SATB1 RABEP1 LRP1 MACF1 ATXN10 PLEC VARS1 PCM1 AGAP1

6.54e-0712851231835914814
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYH2 KRT5 MYH3 MYH6 PCDHGC5 KDM5A SYNE1 MRPS35 LAMP5 ZDHHC17 RYR2 DST ATAD3A MACF1 KDR PLEC MAPK6 VARS1 KIF11

7.74e-0714421231935575683
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1B LRP1 LRP6 LRP5

8.51e-0721123421337463
Pubmed

Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.

MYH2 MYH3 RYR1

8.57e-076123310444070
Pubmed

A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.

KEAP1 KBTBD7 KLHL11 KBTBD4

1.25e-0623123433130828
Pubmed

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

MYH2 MYH3 MYH6

1.50e-067123316819597
Pubmed

Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.

KEAP1 KBTBD7 KBTBD4 KLHL12 KLHL26

1.84e-0657123534878901
Pubmed

Epidermolysis Bullosa Simplex

KRT5 DST PLEC

2.39e-068123320301543
Pubmed

Gut-liver axis calibrates intestinal stem cell fitness.

TLR4 LRP6 LRP5

2.39e-068123338280375
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

KDM5A KEAP1 KIF20B DST SATB1 RABEP1 LRP1 PLEC PCM1 KIF11

2.53e-064181231034709266
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

MYH2 NPEPPS MRPS35 CEP192 KEAP1 RFC3 CERT1 DDB2 TGM3 CPNE3 LRP1 PLEC USP48 VARS1 KIF11

2.83e-0610051231519615732
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

AGAP5 TBC1D2B NFASC AGAP11 KEAP1 DST AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.02e-065291231114621295
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

AGAP5 NFASC AGAP11 GK MACF1 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.26e-064301231032581705
Pubmed

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.

AGAP5 AGAP11 AGAP9 AGAP4 AGAP6 AGAP1

3.74e-06116123630652415
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

KBTBD3 ABR NPEPPS PLCXD1 NFASC CEP192 CERT1 BRWD3 GRK3 ATAD3A RABEP1 LRP1 LRP5 MACF1 MAPK6 PCM1 AGAP1 KLHL26

5.18e-0614891231828611215
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

KRT5 DST PLEC

6.98e-0611123316757171
Pubmed

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

DST LRP6 MACF1

6.98e-0611123316815997
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

KRT5 DST PLEC

6.98e-0611123312802069
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

CEP192 KEAP1 DST RABEP1 MACF1 PCM1 WWC1

1.01e-05209123736779422
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

MYH3 KALRN KDM5A SYNE1 RYR1 DST RABEP1 MACF1 ATXN10 PLEC

1.15e-054971231023414517
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

KRT5 DST PLEC

1.20e-0513123322962592
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

KRT5 DST PLEC

1.20e-051312339670011
Pubmed

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.

LRP1 ADAM17

1.24e-052123220610799
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1B LRP1

1.24e-052123215963947
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

DST MACF1

1.24e-052123211002341
Pubmed

Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation.

ATR KDR

1.24e-052123229743977
Pubmed

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.

LRP6 LRP5

1.24e-052123215084453
Pubmed

Skeletal muscle TLR4 and TACE are associated with body fat percentage in older adults.

TLR4 ADAM17

1.24e-052123226988770
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

1.24e-052123214722100
Pubmed

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.

F8 LRP1

1.24e-052123225903134
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

1.24e-052123226009179
Pubmed

Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.

LRP6 LRP5

1.24e-052123233164872
Pubmed

Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice.

ACE ADAM17

1.24e-052123210187843
Pubmed

Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.

LRP6 LRP5

1.24e-052123225783012
Pubmed

Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma.

ACVRL1 KDR

1.24e-052123227248821
Pubmed

Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.

LRP6 LRP5

1.24e-052123219147944
Pubmed

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.

LRP6 LRP5

1.24e-052123215537447
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

1.24e-052123215033925
Pubmed

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.

LRP6 LRP5

1.24e-052123219503830
Pubmed

Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.

LRP6 LRP5

1.24e-052123228425175
Pubmed

An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury.

TLR4 KDR

1.24e-052123226655705
Pubmed

Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.

GPR179 TRPM1

1.24e-052123224114537
Pubmed

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.

LRP1 LRP6

1.24e-052123226031789
Pubmed

Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).

LRP6 LRP5

1.24e-052123233118644
Pubmed

Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.

LRP6 LRP5

1.24e-052123218493104
Pubmed

Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.

CELA2A CELA2B

1.24e-052123228386233
Pubmed

Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.

CELA2A CELA2B

1.24e-05212323646943
Pubmed

Cross-regulation by TLR4 and T cell Ig mucin-3 determines severity of liver injury in a CCl4-induced mouse model.

HAVCR2 TLR4

1.24e-052123231733121
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

1.24e-052123225370123
Pubmed

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.

LRP6 LRP5

1.24e-052123212579474
Pubmed

High factor VIII activity, high plasminogen activator inhibitor 1 antigen levels and low factor XII activity contribute to a thrombophilic tendency in elderly venous thromboembolism patients.

F8 F12

1.24e-052123221071930
Pubmed

T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.

HAVCR2 TLR4

1.24e-052123223365080
Pubmed

Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.

LRP6 LRP5

1.24e-052123221887268
Pubmed

PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.

LRP6 LRP5

1.24e-052123233136328
Pubmed

Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.

F8 LRP1

1.24e-052123227794518
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

1.24e-052123217259277
Pubmed

A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.

F8 LRP1

1.24e-052123228431990
Pubmed

Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain.

F8 LRP1

1.24e-052123216839343
Pubmed

In vitro cultured progenitors and precursors of cardiac cell lineages from human normal and post-ischemic hearts.

F8 KDR

1.24e-052123218162457
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

1.24e-052123232899693
Pubmed

LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.

LRP6 LRP5

1.24e-052123225902418
Pubmed

Toll-like receptor 4-induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca2+ leakage promote cardiac contractile dysfunction in sepsis.

RYR2 TLR4

1.24e-052123229150444
Pubmed

The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.

LRP6 LRP5

1.24e-052123230474181
Pubmed

In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.

LRP6 LRP5

1.24e-052123236552732
Pubmed

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.

LRP6 LRP5

1.24e-052123217335347
Pubmed

T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner.

HAVCR2 TLR4

1.24e-052123220637206
Pubmed

LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.

LRP6 LRP5

1.24e-052123237202775
Pubmed

Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.

LRP6 LRP5

1.24e-052123220926594
Pubmed

Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.

LRP6 LRP5

1.24e-052123216355283
Pubmed

Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation.

F8 LRP1

1.24e-052123218166789
Pubmed

Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.

LRP6 LRP5

1.24e-052123218350154
Pubmed

Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII.

F8 LRP1

1.24e-052123225486042
Pubmed

Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.

CELA2A CELA2B

1.24e-052123216327289
Pubmed

Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.

ABCA1 ATP8A1

1.24e-052123230282721
Pubmed

Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.

LRP6 LRP5

1.24e-052123230668923
Pubmed

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

LRP6 LRP5

1.24e-052123222433869
Pubmed

Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.

HAVCR2 TLR4

1.24e-052123226208474
Pubmed

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.

LRP6 LRP5

1.24e-052123225802278
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

1.24e-052123230542613
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

1.24e-052123215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

1.24e-052123211673493
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

1.24e-052123211673462
Pubmed

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.

LRP6 LRP5

1.24e-052123233545636
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

1.24e-052123218618700
Pubmed

A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization.

ATP8B3 ATP8A1

1.24e-052123214975727
Pubmed

Update on the Kelch-like (KLHL) gene family.

KEAP1 KLHL11 KLHL12 KLHL26

1.36e-0541123423676014
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

KBTBD7 KLHL11 KBTBD4 KLHL12 KLHL26

1.49e-0587123537495603
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

ABCA1 LRP1 LRP6

1.53e-0514123317389516
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

MYH2 MYH3 MYH6 NPEPPS SORCS1 TGM3 ATAD3A TTI1 ADAM17 ATXN10 PLEC

1.99e-056471231126618866
Cytoband12p13.2

LRP6 TAS2R43 TAS2R46

2.45e-0445123312p13.2
Cytoband12p11

KDM5A MRPS35

2.53e-049123212p11
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP5 AGAP11 AGAP9 AGAP4 AGAP6 AGAP1

2.56e-10179861291
GeneFamilyArfGAPs

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

4.21e-1033987395
GeneFamilyLow density lipoprotein receptors

LRP1B LRP1 LRP6 LRP5

5.59e-0713984634
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KBTBD3 KEAP1 KBTBD7 KLHL11 KBTBD4 KBTBD13 KLHL12 KLHL26

6.63e-07134988861
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP5 ABR CERT1 GRK3 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.78e-06206989682
GeneFamilyAnkyrin repeat domain containing

ANKRD13B AGAP5 AGAP11 ZDHHC17 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.64e-06242989403
GeneFamilyEF-hand domain containing|Plakins

DST MACF1 PLEC

8.48e-068983939
GeneFamilyMyosin heavy chains

MYH2 MYH3 MYH6

6.70e-05159831098
GeneFamilyKelch like|BTB domain containing

KEAP1 KLHL11 KLHL12 KLHL26

7.76e-0542984617
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

8.69e-053982287
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ITGA4 ACE TLR4 LRP1 KDR ADAM17 FUT3 LY75

1.35e-03394988471
GeneFamilyATPase phospholipid transporting

ATP8B3 ATP8A1

2.92e-03159821210
CoexpressionTHEODOROU_MAMMARY_TUMORIGENESIS

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

3.65e-10371227MM1121
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.32e-09441227MM485
CoexpressionKARLSSON_TGFB1_TARGETS_DN

AGAP5 TBC1D2B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

6.32e-062091228MM1058
CoexpressionKUMAR_AUTOPHAGY_NETWORK

KERA CPZ PXK KLHL11 FUCA2

2.19e-05721225M2539
CoexpressionGSE7548_NAIVE_VS_DAY28_PCC_IMMUNIZATION_CD4_TCELL_UP

MYH6 NPEPPS CAMTA2 KEAP1 THBS3 SATB1 TRPM1

4.19e-051991227M6839
CoexpressionDEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN

ABR ATR SYNM TBC1D2B DDB2 LRP5 ADAM17 PLEC

4.67e-052761228M3063
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GK GRK3

2.29e-0816812384b5be7c6662eceddf90a65015f12908278d1664e
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GK GRK3

2.29e-081681238689c41f6e9f65381570991cc311cba49a57ec955
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GRK3 LRP1

2.39e-081691238b059304543876f514d5c7214f1f0a2da00f10a67
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GRK3 LRP1

2.39e-081691238945f737984c4de70a4e9c214053b005358053dd5
ToppCelldroplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GRK3 LRP1

2.62e-081711238ed5886d6aa87b2d73469d39dc217227bd4d4c918
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

ITGA4 ACVRL1 ACE DST MACF1 KDR ADGRF5 PLEC

8.48e-08199123811c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GRK3

3.59e-071631237f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GRK3

3.75e-071641237ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCelldroplet-Kidney-nan-24m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 TGM3 CORO1A GRK3 LRP1

4.23e-0716712372ee1660be117e20f24557522345572d11cbee813
ToppCelldroplet-Lung-nan-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 HAVCR2 TGM3 GK GRK3

4.59e-071691237ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCelldroplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 HAVCR2 TGM3 GK GRK3

4.59e-071691237c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCelldroplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 HAVCR2 TGM3 CORO1A GRK3

4.77e-0717012374d28dc9eb572f43809619f923978cd7494853d43
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

ABR CERT1 HAVCR2 GK GRK3 LRP1 ADAM17

1.12e-061931237cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCelldroplet-Bladder-Unstain-18m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNM ACE PPP1R3A KCNJ8 KBTBD13 KDR ADGRF5

1.16e-0619412379d7cbbcf995274019ca10be0562f114513ec197a
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCA1 ABR CERT1 HAVCR2 GK LRP1 ADAM17

1.20e-0619512379d649ac7d2af313481069c95349efc0c68449e2b
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

KALRN SYNE1 ACVRL1 ACE LRP1B KDR ADGRF5

1.24e-0619612374ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ABCA1 SYNE1 COL6A5 RYR2 DST LRP1 MACF1

1.28e-061971237fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNM MAP6D1 NFASC PXK DST ATP8A1 AGAP1

1.28e-06197123782b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA1 SYNE1 COL6A5 RYR2 DST LRP1 MACF1

1.37e-061991237a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

ITGA4 ACVRL1 ACE DST KDR ADGRF5 PLEC

1.42e-062001237e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ITGA4 ACVRL1 ACE DST MACF1 KDR ADGRF5

1.42e-06200123779e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

ITGA4 ACVRL1 ACE DST KDR ADGRF5 PLEC

1.42e-0620012373372c488a39fe812fa94e4f0564594186fea3db5
ToppCelldroplet-Fat-Scat-21m-Myeloid-monocyte|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 ITGA4 RYR1 TGM3 CORO1A GRK3

3.83e-061501236b6e5e04aaf1c5265ac07581868d3159f9292a84c
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRX1 ACE RYR1 GRK3 CPNE3 LRP1

4.13e-06152123682a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 BRWD3 HAVCR2 CORO1A ATP8A1 GRK3

4.13e-0615212367e686721b95c837f2b0d5116927c8ecacef055ee
ToppCelldroplet-Fat-Scat-21m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 ITGA4 RYR1 TGM3 CORO1A GRK3

5.16e-061581236c8df636412a08c570f235c34d4cff46924a9b11d
ToppCelldroplet-Fat-Scat-21m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 ITGA4 RYR1 TGM3 CORO1A GRK3

5.16e-061581236718eafcf8a171bb69b402dc9d69564c3521a62a9
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE CORO1A GRK3 PTPRH LY75

5.16e-06158123690ca742739a208d457db087655ba3d1c18a9da57
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

MYH2 KALRN LAMP5 RYR2 TGM3 SATB1

5.35e-06159123618e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE CORO1A GRK3 PTPRH LY75

5.55e-0616012368dae9b0cf90a09acb196223f45a14680102630b2
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL6A5 RYR2 KLHL11 DST LRP5 MACF1

5.55e-0616012360293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL6A5 RYR2 KLHL11 DST LRP5 MACF1

5.55e-0616012363eaae86fa08f7651021316f8e5811bf48055591e
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 RYR1 HAVCR2 TGM3 CORO1A GRK3

6.17e-061631236bbbc3f0ce2616d07136f69ce682ba1d3790711d9
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 RYR1 HAVCR2 TGM3 CORO1A GRK3

6.39e-06164123611dfd84f5fb90de330858e1e852848832734e004
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 KALRN ITGA4 ACE GRK3 LRP1

7.34e-061681236e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 LRP1B FAM78A CORO1A SATB1 TRPM1

7.34e-06168123668ee3b3b012b56584e313813feb16e632e3f72d2
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TBC1D2B ITGA4 CORO1A GK GRK3 LRP1

7.34e-061681236c0aef5947b1d7e2c81a7481c509feda1687fcd7f
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TBC1D2B ITGA4 CORO1A GK GRK3 LRP1

7.34e-061681236c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 HAVCR2 TGM3 GRK3

7.59e-061691236411556e93adcbb7e4d79b02f3dc72963ec8a0759
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SYNM MAP6D1 ACE CERT1 KBTBD7 THBS3

7.59e-061691236b66ffc2b2b6bfcc3a6e639d9d31d3de95f4a94e1
ToppCelldroplet-Lung-LUNG-30m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 HAVCR2 TGM3 GRK3

7.59e-06169123639b1acfd099abb9de18c29c05c7a67709ea76775
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 LRP1B FAM78A CORO1A SATB1 TRPM1

7.85e-06170123667e78e3c1d4cd3c6eaa5d0a9785b6cd8a3b08039
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 TGM3 CORO1A GRK3

8.12e-06171123600739085fdbc4d64c9faacba2c2adeab580dd2b1
ToppCelldroplet-Lung-nan-21m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 TGM3 CORO1A GRK3

8.40e-06172123651bea97564a33f0060c546c9be4bf8bf8f1660f6
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA4 ACE RYR1 TGM3 CORO1A GRK3

8.40e-0617212365f58ff6cac32546d07b2a49ed250b6c7aa417188
ToppCelldroplet-Lung-nan-21m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE RYR1 TGM3 CORO1A GRK3

8.40e-061721236be4dd4ba8d7a651677c797c25fd75f14e627415a
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE TGM3 CORO1A GRK3 KBTBD13

8.40e-061721236a125ac2db9c8ece95970a93aa6f7918d1dcef886
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 ACE TGM3 CORO1A GRK3 KBTBD13

8.40e-0617212366aab59add5b180cee0ca31179c620e89d352d5c1
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 SYNE1 ACE GRK3 LRP1 AGAP1

9.27e-061751236cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SYNM GPR162 SORCS1 ATP8A1 NALF2 KCNH5

9.89e-06177123615a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 KIF20B CPNE3 LY75 KIF11 AGAP1

1.02e-05178123615a99080e9f669572ab6d82934f324e6714846c1
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 KIF20B CPNE3 LY75 KIF11 AGAP1

1.02e-051781236200308e109abb7e6f8816a6f8cce6d56862d4098
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFASC COL6A5 ITGA4 GRK3 ADGRF5 NALF2

1.02e-05178123630ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE F8 PPP1R3A MACF1 KDR ADGRF5

1.09e-051801236dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE F8 PPP1R3A MACF1 KDR ADGRF5

1.09e-051801236423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

KALRN SYNE1 ACVRL1 ACE KDR ADGRF5

1.12e-051811236c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellCOVID-19-kidney-Mito-rich_EC|kidney / Disease (COVID-19 only), tissue and cell type

KALRN SYNE1 ACVRL1 F8 KDR ADGRF5

1.19e-0518312363c4153479fc4ab2d073d92cee120480015555914
ToppCelldroplet-Spleen-nan-3m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA4 PXK FAM78A CORO1A SATB1 MACF1

1.31e-05186123626f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCelldroplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPEPPS SYNE1 RFC3 PXK CPNE3 LY75

1.35e-05187123614c239af77116d28d511dea754b6150d20488080
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

KALRN SYNE1 TBC1D2B ACE ADGRF5 AGAP1

1.39e-0518812361aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

KALRN SYNM ACVRL1 ACE KDR TAS2R43

1.39e-051881236fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

KALRN SYNM ACVRL1 ACE KDR TAS2R43

1.39e-051881236cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B1|390C / Donor, Lineage, Cell class and subclass (all cells)

MYH3 CELA2A ACOT4 CORO1A PTPRH

1.43e-0511112359972d31966b059aa3446407b73b714b0b06ec815
ToppCellmoderate-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SORCS1 ADRA2C DST KDR ADGRF5 TRPM1

1.43e-05189123622a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCellfacs-Lung-Endomucin_-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ACVRL1 ACE KDR ADGRF5 PLEC

1.57e-051921236ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCellEC|World / Lineage and Cell class

ACVRL1 F8 ADRA2C KCNJ8 KDR ADGRF5

1.57e-051921236478866dd5b0d6ff3a76d07a17c4b5989dd7a27bb
ToppCellfacs-Lung-Endomucin_|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ACVRL1 ACE KDR ADGRF5 PLEC

1.57e-05192123685d4d0df701451daf95e94a87a0096da1e86533b
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

ABCA1 ABR HAVCR2 GK GRK3 LRP1

1.57e-051921236733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ACVRL1 ACE KDR ADGRF5 PLEC

1.62e-0519312362218833749576ba1a0fc95bd155c781e7e1163c6
ToppCellfacs-Lung-Endomucin_-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ACVRL1 ACE KDR ADGRF5 PLEC

1.66e-051941236df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCelldroplet-Bladder-Unstain-18m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNM ACE KCNJ8 KBTBD13 KDR ADGRF5

1.71e-051951236fbfe4a8ae9775764108b45920eec92003b24fb2e
ToppCellImmune-alveolar_macrophage_(MARCO_positive)|World / Lineage, Cell type, age group and donor

ABR HAVCR2 GK GRK3 LRP1 ADAM17

1.71e-051951236f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR SYNE1 ACVRL1 F8 KDR ADGRF5

1.71e-05195123623ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

ABCA1 ABR HAVCR2 GK GRK3 LRP1

1.71e-051951236148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCelldroplet-Bladder-Unstain-18m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNM ACE KCNJ8 KBTBD13 KDR ADGRF5

1.71e-0519512362a6056172c41c46acfe0242be22269ef1d07921e
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 DST GRK3 SATB1 MACF1 PCM1

1.71e-0519512363e519cffa6144a62b06124642a14c9ff39b76554
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

ABCA1 ABR HAVCR2 GK GRK3 LRP1

1.71e-05195123655e25f702af19146a161861cfd15f40bbda1dc35
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 DST GRK3 SATB1 MACF1 PCM1

1.71e-0519512367796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 ACVRL1 F8 TLR4 KDR ADGRF5

1.76e-051961236d323f7dc41380446e5967c69832bea88351a9331
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 ACVRL1 F8 TLR4 KDR ADGRF5

1.76e-05196123665d882c6e7f6d5778b8a5fd4fdaf012e1b9f6100
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

KALRN SYNE1 ACVRL1 ACE KDR ADGRF5

1.76e-05196123649cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

ABCA1 ABR HAVCR2 GK GRK3 LRP1

1.76e-0519612367026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA1 ABR RYR1 GK GRK3 LRP1

1.81e-0519712368af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA1 ITGA4 RYR1 HAVCR2 GRK3 TLR4

1.81e-05197123610190b877bf46ba2163d203df9dd3b498c66e52f
ToppCellCOVID-19-Myeloid|COVID-19 / group, cell type (main and fine annotations)

ABCA1 ABR GK GRK3 TLR4 LRP1

1.87e-05198123633f0a919188a67d2a876b52c61a1cec2c9747969
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 ACVRL1 F8 TLR4 KDR ADGRF5

1.92e-0519912365d976d57872a8a25a11fe8cd53b01aa21a1a519a
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN SYNM NFASC CELA2B RYR2 ADRA2C

1.92e-051991236b768496381362f9a2706e0892b5a7a0db82e09ce
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SYNE1 COL6A5 CPZ DST LRP1 MACF1

1.92e-051991236e1849505b92820a219c5a2c35492bdd55579fb48
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA1 SYNE1 COL6A5 RYR2 LRP1 LRP6

1.92e-0519912368b86c69aaf60feff53aa782559cfece7342a23de
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ACVRL1 ACE DST MACF1 KDR ADGRF5

1.97e-05200123672ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ACVRL1 ACE DST MACF1 KDR ADGRF5

1.97e-052001236dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SYNE1 COL6A5 CPZ DST LRP1 MACF1

1.97e-052001236b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SYNE1 COL6A5 CPZ DST LRP1 MACF1

1.97e-05200123650ca6550998e461ef26dd670351060bd940765a8
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ACVRL1 ACE DST MACF1 KDR ADGRF5

1.97e-0520012365c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

ACVRL1 ACE DST MACF1 KDR ADGRF5

1.97e-05200123681e76508c9050d533853d5fd2f3097b27613d836
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

ACVRL1 ACE DST MACF1 KDR ADGRF5

1.97e-0520012363b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_IL1RA-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ITGA4 ACVRL1 ACE KDR ADGRF5 PLEC

1.97e-0520012367034f57e282982c19c13ee8ab78eabaffa069e30
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ACVRL1 ACE DST MACF1 KDR ADGRF5

1.97e-052001236a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SYNE1 COL6A5 CPZ DST LRP1 MACF1

1.97e-05200123644a68bacdb3d5bf563bd35952176995850933a81
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

ITGA4 ACVRL1 ACE KDR ADGRF5 PLEC

1.97e-052001236be55cef682ba87250dad97689332c8820b3a7420
DrugHarmine hydrochloride [343-27-1]; Up 200; 16uM; HL60; HG-U133A

ABCA1 ATR KDM5A TBC1D2B LAMP5 DDB2 KIF20B KBTBD4 PLEC

1.27e-0619712391758_UP
Drug4,4'-dithiodipyridine

KEAP1 GPR162 F12 RYR1 RYR2

4.36e-06451235CID000075846
DrugAC1MO44G

ATR ACE F8 F12 HAVCR2 DST

1.07e-05921236CID003363161
DrugKanamycin A sulfate [25389-94-0]; Up 200; 6.8uM; PC3; HT_HG-U133A

MYH2 SPHK2 ITGA4 F12 RYR2 CPLANE1 NALF2 SENP7

1.20e-0519712384625_UP
Diseasecerebral palsy (implicated_via_orthology)

AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1

1.94e-15101217DOID:1969 (implicated_via_orthology)
Diseaseepidermolysis bullosa simplex (is_implicated_in)

KRT5 DST PLEC

2.33e-0671213DOID:4644 (is_implicated_in)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH2 MYH3 MYH6

7.90e-06101213DOID:0080326 (implicated_via_orthology)
Diseasecardiomyopathy (implicated_via_orthology)

MYH2 MYH3 MYH6 SPHK2 LRP1

1.12e-05711215DOID:0050700 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH2 MYH3 MYH6

1.44e-05121213DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH2 MYH3 MYH6

1.44e-05121213DOID:2106 (implicated_via_orthology)
Diseasered blood cell density measurement

ATR KALRN ACVRL1 KIF20B PXK THBS3 DST RABEP1 ADGRF5 PLEC LY75 KIF11 SENP7 AGAP1

1.57e-0588012114EFO_0007978
Diseaseresponse to radiation, prostate carcinoma, erectile dysfunction

TDRD15 CELA2A CELA2B LRP1B

1.60e-05371214EFO_0001663, EFO_0004234, GO_0009314
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH2 MYH3 MYH6

1.87e-05131213DOID:397 (implicated_via_orthology)
Diseasesphingomyelin measurement

TDRD15 KRT5 SPHK2 ABCA1 CAMTA2 ACVRL1 CERT1 RABEP1

2.01e-052781218EFO_0010118
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH2 MYH3 MYH6

2.95e-05151213DOID:0050646 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

4.99e-0531212DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

4.99e-0531212DOID:8545 (implicated_via_orthology)
DiseaseEPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder)

KRT5 DST

4.99e-0531212C1832926
Diseasemyocardial infarction (is_implicated_in)

ACE F12 TLR4 LRP1 KDR

5.61e-05991215DOID:5844 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

KALRN NFASC LRP1B LRP1 ATP4B KCNH5

5.90e-051631216DOID:1826 (implicated_via_orthology)
DiseaseMultiple pterygium syndrome

MYH3 RYR1

9.95e-0541212C0265261
Diseaserenal fibrosis (is_marker_for)

ACE ADAM17

9.95e-0541212DOID:0050855 (is_marker_for)
DiseaseEpidermolysis Bullosa Simplex

KRT5 DST

1.65e-0451212C0079298
Diseasestomach cancer (is_implicated_in)

ACE LRP1B KDR ATP4B

2.23e-04721214DOID:10534 (is_implicated_in)
DiseaseDisorder of eye

PEX7 GPR179 FREM2 LRP5 TRPM1 CPLANE1

2.48e-042121216C0015397
DiseaseMASA syndrome (implicated_via_orthology)

NFASC TRPM1

3.46e-0471212DOID:0060246 (implicated_via_orthology)
Diseasefamilial Mediterranean fever (is_implicated_in)

ACE TLR4

5.89e-0491212DOID:2987 (is_implicated_in)
Diseasetype 2 diabetes mellitus (is_implicated_in)

ABCA1 ACE PPP1R3A TLR4 ADAM17

7.13e-041711215DOID:9352 (is_implicated_in)
Diseasetriglycerides in large LDL measurement

TDRD15 SPHK2 ABCA1

7.36e-04431213EFO_0022319
Diseasecoronary artery disease (is_implicated_in)

ABCA1 KALRN ACE TLR4

7.79e-041001214DOID:3393 (is_implicated_in)
DiseaseTachycardia, Ventricular

RYR2 KCNJ8

8.95e-04111212C0042514
DiseaseShortened QT interval

KCNJ8 LRP5

8.95e-04111212C0151879
Diseasehyperhomocysteinemia (implicated_via_orthology)

F8 F12

8.95e-04111212DOID:9279 (implicated_via_orthology)
Diseasehepatocellular carcinoma (is_implicated_in)

ACE LRP1B HAVCR2 TLR4 KDR

9.20e-041811215DOID:684 (is_implicated_in)
Diseasemyopathy (implicated_via_orthology)

MYH2 MYH3 MYH6

1.02e-03481213DOID:423 (implicated_via_orthology)
DiseaseNight blindness, congenital stationary, type 1

GPR179 TRPM1

1.07e-03121212C3501847
DiseaseNight Blindness, Congenital Stationary, Type 1A

GPR179 TRPM1

1.07e-03121212C3495587
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)

GPR179 TRPM1

1.07e-03121212C1864877
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B

GPR179 TRPM1

1.07e-03121212C1850362
DiseaseX-Linked Csnb

GPR179 TRPM1

1.07e-03121212C3711543
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A

GPR179 TRPM1

1.07e-03121212C1848172
DiseaseHMG CoA reductase inhibitor use measurement

TDRD15 ABCA1 ACVRL1 CERT1 PLEC

1.12e-031891215EFO_0009932
Diseaselung disease (implicated_via_orthology)

ACE TLR4

1.26e-03131212DOID:850 (implicated_via_orthology)
Diseaseximenoylcarnitine (C26:1) measurement

CPNE3 LRP5

1.26e-03131212EFO_0800543
DiseaseCone-rod synaptic disorder, congenital nonprogressive

GPR179 TRPM1

1.26e-03131212C4041558
Diseasegallbladder cancer (is_implicated_in)

KEAP1 LRP1B

1.26e-03131212DOID:3121 (is_implicated_in)
Diseasetotal lipids in LDL measurement

TDRD15 ABCA1 CERT1

1.28e-03521213EFO_0022308
Diseaseneuroblastoma

TDRD15 KRT5 KALRN CPZ

1.35e-031161214EFO_0000621
Diseasetriglycerides in LDL measurement

TDRD15 SPHK2 ABCA1

1.59e-03561213EFO_0022320
DiseaseHypertrophic Cardiomyopathy

MYH6 RYR2 ATAD3A

1.67e-03571213C0007194
Diseaselow density lipoprotein triglyceride measurement

TDRD15 SFSWAP

1.69e-03151212EFO_0009946
DiseaseSinus Node Dysfunction (disorder)

MYH6 KCNJ8

1.69e-03151212C0428908
DiseaseAtherosclerosis

ABCA1 CELA2A TLR4

1.85e-03591213C0004153
DiseaseAtherogenesis

ABCA1 CELA2A TLR4

1.85e-03591213C1563937
Diseasetriglycerides in medium LDL measurement

TDRD15 SPHK2 ABCA1

2.13e-03621213EFO_0022322
DiseaseAlzheimer's disease (is_implicated_in)

ABCA1 TLR4 LRP1 ADAM17

2.17e-031321214DOID:10652 (is_implicated_in)
DiseaseRenal Insufficiency

ACE TLR4

2.18e-03171212C1565489
Diseaserenal fibrosis (implicated_via_orthology)

ACE TLR4

2.18e-03171212DOID:0050855 (implicated_via_orthology)
DiseaseNight blindness, congenital stationary

GPR179 TRPM1

2.18e-03171212C0339535
Diseaselevel of Sphingomyelin (d32:1) in blood serum

RABEP1 KCNH5

2.18e-03171212OBA_2045173
DiseaseVan Buchem disease

LRP5 KDR

2.18e-03171212C0432272
Diseasechronic obstructive pulmonary disease (is_implicated_in)

ACE LRP1B TLR4

2.23e-03631213DOID:3083 (is_implicated_in)
DiseaseCCL5 measurement

SYNE1 F12 ATXN10

2.34e-03641213EFO_0005117
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

TDRD15 ABCA1 NPEPPS CERT1 MACF1

2.39e-032251215EFO_0008317, EFO_0020947
Diseasetype 2 diabetes mellitus (is_marker_for)

F8 F12 TLR4 KDR

2.42e-031361214DOID:9352 (is_marker_for)
Diseasemyocardial infarction (implicated_via_orthology)

ACE RYR1 KDR

2.55e-03661213DOID:5844 (implicated_via_orthology)
Diseaseankylosing spondylitis (is_implicated_in)

KDM5A ACE

2.72e-03191212DOID:7147 (is_implicated_in)
Diseasenon-high density lipoprotein cholesterol measurement

TDRD15 ABCA1 NPEPPS KEAP1 CERT1 PXK THBS3 RABEP1 FUT3

2.73e-037131219EFO_0005689
Diseasebipolar I disorder

TDRD15 SYNE1 PRSS36 PLEC

2.76e-031411214EFO_0009963
Diseasechemokine (C-C motif) ligand 27 measurement

RFC3 F12 USP48

3.01e-03701213EFO_0008082
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

TDRD15 MYH2 ABCA1 CERT1 MACF1

3.10e-032391215EFO_0008317, EFO_0020945
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

KEAP1 LRP1B RYR1 KDR

3.28e-031481214C0279702
DiseaseDeep Vein Thrombosis

F8 KDR

3.33e-03211212C0149871
DiseaseVenous Thrombosis

F8 KDR

3.33e-03211212C0042487
Diseaselung cancer (is_implicated_in)

ATR ACE LRP1B

3.53e-03741213DOID:1324 (is_implicated_in)
DiseaseKidney Failure

ACE TLR4

3.65e-03221212C0035078
DiseaseProstatic Neoplasms

ABR ATR KEAP1 ACE LRP1B ATAD3A TLR4 CPNE3

3.95e-036161218C0033578
DiseaseMalignant neoplasm of prostate

ABR ATR KEAP1 ACE LRP1B ATAD3A TLR4 CPNE3

3.95e-036161218C0376358

Protein segments in the cluster

PeptideGeneStartEntry
LSSDYERSEWREAIQ

ABR

441

Q12979
EATTYEERDAWVQAI

AGAP4

401

Q96P64
RWQQEVTETVYEAVN

GRK3

516

P35626
TYEERDAWVQAIQSQ

AGAP11

291

Q8TF27
TTYEERDAWVQAIES

AGAP1

571

Q9UPQ3
TTYEERDAWVQAIQS

AGAP9

471

Q5VTM2
KFVEEYDRTSQVVWN

ACE

651

P12821
YDRTSQVVWNEYAEA

ACE

656

P12821
WTADRLDAVVVSTNY

AADAC

131

P22760
QWVIYAIRNLTEDNS

ATXN10

416

Q9UBB4
SLDRYWSVTQAVEYN

ADRA2C

146

P18825
REIAQLAVSWQATAY

ATAD3A

576

Q9NVI7
VYTWREAFNETNQAI

ABCA1

481

O95477
WNTNEEIASYLITFE

CAMTA2

41

O94983
NTSGQQWYEVERTER

CPNE3

36

O75131
WDRYDTTVITAVNNF

BRWD3

431

Q6RI45
EQSWFRETEIYNTVL

ACVRL1

236

P37023
EISRILETYWENSNN

ATP8B3

791

O60423
ADQCYEDVRVSQTTW

CORO1A

21

P31146
VFTRVSNYIDWINSV

CELA2A

251

P08217
IVYNVSDNRTWADLT

ATP4B

96

P51164
EWRAVYQRASTSVQN

ATP8A1

621

Q9Y2Q0
EATTYEERDAWVQAI

AGAP6

401

Q5VW22
LEQERTQWAQYRESA

RABEP1

136

Q15276
TQWAQYRESAEREIA

RABEP1

141

Q15276
TDEVQVYHSNRSEWE

KBTBD3

566

Q8NAB2
WTYENREALVANDSE

PPP2R3C

431

Q969Q6
SEYDQVTIWEALTNS

ANKRD13B

521

Q86YJ7
FDISVNDSVWYLRAQ

CERT1

86

Q9Y5P4
DREQQSSYTLWVEAV

PCDH20

701

Q8N6Y1
TTQARTSYIAEEIQW

KCNJ8

306

Q15842
RNLYWISSEFDETQI

LRP1B

1661

Q9NZR2
YESIRVSSELQQTWT

FSCB

46

Q5H9T9
AVVQLRRQASSDYDW

GPR162

71

Q16538
SSVEEDVEWYQALVR

GPR179

121

Q6PRD1
QTLEDSWRYEETSEN

WWC1

836

Q8IX03
EEVAYDWSERNTNIA

DST

721

Q03001
SLNTRTVYFSEQWVS

KIF11

821

P52732
TVYFSEQWVSSLNER

KIF11

826

P52732
NVYWTDSGRDVIEVA

LRP1

3971

Q07954
YEEIANRSRTEAESW

KRT5

346

P13647
YERTVTEWQQQDITE

FREM2

636

Q5SZK8
AVYWTDVSEEAIKQT

LRP5

76

O75197
IDEVTNTIQIDSWLY

KCNH5

376

Q8NCM2
QENLRWVSELSYVEE

PCM1

981

Q15154
SSYLDNLVWRESEVN

MAPK6

451

Q16659
WVSGQLRYSVVEESE

PCDHGC5

26

Q9Y5F6
NTEVAQWRTKYETDA

MYH2

1371

Q9UKX2
AQEVYSVDWSQTRGE

PEX7

111

O00628
IREEVTQEFTQYWAQ

KIF20B

601

Q96Q89
EYREEGSQIWQQSVA

KALRN

2606

O60229
NLYWTDTGTDRIEVT

LRP6

416

O75581
NTVELTDVWTYSDTR

LY75

346

O60449
DVWASNYVDLITEQA

LAMP5

71

Q9UJQ1
SVFDENRSWYLTENI

F8

596

P00451
SEYFSVTQQECQRWV

NALF2

296

O75949
NRVTVYEYDTREDQW

KBTBD7

581

Q8WVZ9
VSEYWSVILSEVQRN

NLRX1

906

Q86UT6
WTQFVSADYTRAQEL

NPEPPSL1

396

A6NEC2
TDQKSEIRVYSASQW

DDB2

306

Q92466
LWSRGQQVIVSYEDE

PLCXD1

191

Q9NUJ7
AQSYDTWVSRVTEAL

KDM5A

736

P29375
GISATEVDSRWQEYQ

MACF1

306

Q9UPN3
EVDSRWQEYQSRVDS

MACF1

311

Q9UPN3
RQETNYQDSWVTSKT

MACF1

3146

Q9UPN3
NITSVEESSWVITEY

PPP1R3A

841

Q16821
FTAVATYEAWIREQV

PRSS36

276

Q5K4E3
QAAAREWEVVSVAEY

OXR1

646

Q8N573
AISLQWNRVYSDTVQ

NFASC

841

O94856
AIYETHTWRSQNDTV

FUCA2

366

Q9BTY2
ANRSEWTDELNTYRV

ATR

1761

Q13535
KAVITCYDTETRQWQ

KLHL11

521

Q9NVR0
CYDTETRQWQDVESL

KLHL11

526

Q9NVR0
EAYNIRTDSWTTVTS

KLHL12

491

Q53G59
GIVQVYNTDTDEWER

KLHL26

576

Q53HC5
QHRSWEVVEASSEYI

CPZ

66

Q66K79
IFTRVSNYNDWINSV

CELA2B

251

P08218
VRDQNLSNVWTVEYA

CPLANE1

991

Q9H799
EIWSQISTYAEQRNL

COL6A5

416

A8TX70
QINAEESEIRYSTWK

GK

496

P32189
EATTYEERDAWVQAI

AGAP7P

401

Q5VUJ5
AAAVTTSYRQEFQAW

MAP6D1

126

Q9H9H5
SILQEENRRDSWSYI

ITGA4

1011

P13612
VVYQNEEGRWVTDLA

CEP192

471

Q8TEP8
LNSVERYDVETETWT

KEAP1

531

Q14145
TTYRENEVDWLTELA

HBP1

101

O60381
LQEQDVWRRSTSFYT

SLC12A8

576

A0AV02
RIYFEISETNRAQWE

RYR1

4191

P21817
ERVYFEISESSRTQW

RYR2

4146

Q92736
WTQFVSADYTRAQEL

NPEPPS

396

P55786
WEVYLRETANAIVSQ

RFC3

251

P40938
WASEATYRNVTAEQA

F12

241

P00748
QESRYQTVRSIAAWF

FUT3

346

P21217
YIWENSSSERNILET

MRPS35

251

P82673
NSVEVRTTAYNIWAV

TAS2R43

76

P59537
NSIEVRITAYNVWAV

TAS2R46

76

P59540
RAAVLVQQWVSYADT

VARS1

91

P26640
WVSSDYLQEIQTQLE

SENP7

591

Q9BQF6
STWNRDYQLSEEEAR

SFSWAP

91

Q12872
STLESVISQWNDYVE

SYNE1

2726

Q8NF91
SYALLVAESWRETVQ

SYNM

186

O15061
YKSEDQWNRVEISEV

TDRD15

1791

B5MCY1
TNIYRDQSFTTWLVA

FAM78A

181

Q5JUQ0
YRVGDNVWTETTQLE

KBTBD4

351

Q9NVX7
VVLRTDERDVNYWTS

HAVCR2

66

Q8TDQ0
RSVRQVYEVHDSDDW

KERA

21

O60938
CSQASNERTYQEVVW

SLC38A7

106

Q9NVC3
NSEVAQWRTKYETDA

MYH3

1366

P11055
ANSEVAQWRTKYETD

MYH6

1366

P13533
STNTEVSSEIYQWVR

SATB1

366

Q01826
AEVNADRITWLYDNT

TGM3

391

Q08188
DHNWRSELYAQTVSE

ACOT4

326

Q8N9L9
EVLSSNVSWRYEEQQ

ADGRF5

296

Q8IZF2
DRVDDIYRNTSWDNA

ADAM17

256

P78536
TTYEERDAWVQAIQS

AGAP5

426

A6NIR3
ATYEENRAEAQRWAT

SPHK2

141

Q9NRA0
DTTAVVEYAVRTDAW

KBTBD13

316

C9JR72
VENSWQIVRRYSDFD

PXK

46

Q7Z7A4
IWEIINSEYFTAEQR

PLEC

3061

Q15149
WELISSEYFTAEQRQ

PLEC

3391

Q15149
YSRQDNTRWLEASVV

THBS3

76

P49746
VDWTRQYTIEYDQIS

ZDHHC17

611

Q8IUH5
VEYSSITDQQLTTEW

TRPM1

1456

Q7Z4N2
TIFDRVYTIQSDVWS

KDR

1076

P35968
NTWRQIFEEEHSVLY

SORCS1

576

Q8WY21
EEVSQEHIETAYRIW

USP48

21

Q86UV5
AFVIYSSQDEDWVRN

TLR4

676

O00206
QTSRTNETWYKVEAL

PTPRH

621

Q9HD43
NDSRRTVFYTNEEWE

TBC1D2B

241

Q9UPU7
IVTSILEEYTSQENW

TTI1

556

O43156
EEVLSYSNVISWEQT

GLYATL2

86

Q8WU03