Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RHO	RHOBTB1 RHOBTB2	1.86e-03	20	60	2	PS51420
Domain	FN3	PAPPA2 DSCAM IL21R RIMBP2	2.95e-03	185	60	4	SM00060
Domain	AMP_BINDING	ACSBG1 DIP2C	3.64e-03	28	60	2	PS00455
Domain	ZINC_PROTEASE	PAPPA2 ADAM9 ENPEP	3.86e-03	98	60	3	PS00142
Domain	AMP-binding	ACSBG1 DIP2C	4.17e-03	30	60	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSBG1 DIP2C	4.17e-03	30	60	2	IPR000873
Domain	FN3_dom	PAPPA2 DSCAM IL21R RIMBP2	4.56e-03	209	60	4	IPR003961
Domain	-	TMEM25 PAPPA2 DSCAM HLA-DMB IL21R SIGLEC10 RIMBP2	5.20e-03	663	60	7	2.60.40.10
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	HLA-DMB ADAM9 PPP1R12B RNF213 SLC46A1 TMEM214 ACAD10 ATP8B1 INTS8 CLDN12 CDH16	2.92e-06	1061	63	11	33845483
Pubmed	FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1.	FOXM1 PDK1	3.23e-06	2	63	2	35656815
Pubmed	A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression.	FOXM1 IL27	3.23e-06	2	63	2	29343703
Pubmed	Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.	RHOBTB1 RHOBTB2	9.68e-06	3	63	2	27314390
Pubmed	The Dictyostelium discoideum family of Rho-related proteins.	RHOBTB1 RHOBTB2	9.68e-06	3	63	2	11222756
Pubmed	Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.	RHOBTB1 RHOBTB2	9.68e-06	3	63	2	12426103
Pubmed	Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.	RHOBTB1 RHOBTB2	3.22e-05	5	63	2	18835386
Pubmed	MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.	RHOBTB1 RHOBTB2	4.82e-05	6	63	2	22709582
Pubmed	Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.	IL21R IL27	4.82e-05	6	63	2	19570826
Pubmed	Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.	RHOBTB1 RHOBTB2	8.98e-05	8	63	2	24923387
Pubmed	IFN-γ limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27.	IL21R IL27	1.15e-04	9	63	2	23125412
Pubmed	CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs.	IL21R IL27	1.15e-04	9	63	2	21297642
Pubmed	Genome-wide association study of Alzheimer's disease with psychotic symptoms.	DIP2C RIMBP2	1.76e-04	11	63	2	22005930
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DHX36 STOX2 ACSBG1 NBEAL2 PDCD11 ESPL1	3.93e-04	529	63	6	14621295
Pubmed	Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.	DSCAM PDGFD	7.29e-04	22	63	2	21507922
Pubmed	Calcium-Bound S100P Protein Is a Promiscuous Binding Partner of the Four-Helical Cytokines.	PRL IL27	8.69e-04	24	63	2	36233301
Pubmed	Interaction of S100A6 Protein with the Four-Helical Cytokines.	PRL IL27	1.18e-03	28	63	2	37759746
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	DHX36 WDR36 PDK1 PDCD11 RNF213 TMEM214 ESPL1 METTL17 TEFM	1.43e-03	1496	63	9	32877691
Pubmed	Atypical E2F repressors and activators coordinate placental development.	ESPL1 PRL	1.64e-03	33	63	2	22516201
Pubmed	Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.	PDGFD CLDN12	1.75e-03	34	63	2	25391964
Pubmed	Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development.	PDK1 PRL	1.75e-03	34	63	2	34767447
Cytoband	16p11	IL21R IL27	3.87e-05	7	63	2	16p11
GeneFamily	Rho family GTPases	RHOBTB1 RHOBTB2	9.29e-04	20	41	2	390
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	RHOBTB1 RHOBTB2 KLHL34	3.45e-03	134	41	3	861
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	TMEM25 SIGLEC10	3.71e-03	40	41	2	592
Disease	developmental and epileptic encephalopathy 64 (implicated_via_orthology)	RHOBTB1 RHOBTB2	3.80e-06	2	58	2	DOID:0070375 (implicated_via_orthology)
Disease	pulse pressure measurement	PAPPA2 GLYAT DSCAM RNF213 S1PR2 ACAD10 MEI1 INTS8 ENPEP	1.49e-03	1392	58	9	EFO_0005763
Disease	Anemia	SLC46A1 PRL	2.05e-03	34	58	2	C0002871
Disease	liver cirrhosis (biomarker_via_orthology)	PDGFD ALAD	2.05e-03	34	58	2	DOID:5082 (biomarker_via_orthology)
Disease	corpus callosum anterior volume measurement	CBY2 S1PR2	2.69e-03	39	58	2	EFO_0010295

Protein segments in the cluster

Peptide	Gene	Start	Entry
YSLSVDPNTWQTLLH	GSDMD	121	P57764
TNPLTRSYHTWARPQ	ACAD10	611	Q6JQN1
QAVPQISTLAWYTTL	ATP8B1	131	O43520
FAPNSVHYLLTLWQR	RANBP17	371	Q9H2T7
LVRYTLSINPNNHSW	INTS8	821	Q75QN2
LLRTPSVQLVQSWYI	PDK1	101	Q15118
LVLQGPLTTQYLWHR	SLC46A1	36	Q96NT5
PLTTQYLWHRFSADL	SLC46A1	41	Q96NT5
SPRTWHAQISTSNLY	PAK6	351	Q9NQU5
VYNHRWRSLTQLPTP	KLHL34	341	Q8N239
LRRNLQPTLTYWSVF	MFSD4A	11	Q8N468
YFHPLLRAWQTATTT	ALAD	11	P13716
SYTLQHVPIPRSWNQ	GLYAT	276	Q6IB77
YTLLLLTTPSWVLSQ	IGHV2-26	6	A0A0B4J1V2
NSYPRNLLLTWRLHS	PDGFD	71	Q9GZP0
ISINLSAPTRYLWLH	ENPEP	121	Q07075
VWYTSTTVPLLLANL	OR11L1	71	Q8NGX0
LSHDSWQYVLLIPSV	OVOS2	6	Q6IE36
SPWPLRSLTQSHIQY	POM121L12	51	Q8N7R1
TPTQTWQVYLHSLQR	NPHP4	1221	O75161
PSASLRWHQALYLLE	OXER1	246	Q8TDS5
LYWSLHQTTPSSQKR	MEI1	961	Q5TIA1
RSSEWYQSLNLTHVP	GID4	276	Q8IVV7
TILISHSRYQPGTWT	PAPPA2	351	Q9BXP8
GDQLLHRTYTWQLTL	CBY2	11	Q8NA61
DWTYQTLSHLALTPS	HLA-DMB	171	P28068
YLSLPSNNLSHSLWE	ESPL1	911	Q14674
QIYNHSLTLSARWPR	FCGBP	3336	Q9Y6R7
LQIYNHSLTLSARWP	FCGBP	4536	Q9Y6R7
LQWLQSDPYLSSVSH	DHX36	316	Q9H2U1
SWPQLLSTYRLLHSL	IL27	196	Q8NEV9
LQWRAQTTPDHILYT	DIP2C	976	Q9Y2E4
LPLSHIAAQIYDLWT	ACSBG1	326	Q96GR2
QTSHLSSYEIITPWR	ADAM9	36	Q13443
LFYRTLTWAHTQLII	MBOAT4	376	Q96T53
HLQILSIPGWRYSSN	MAN2B2	876	Q9Y2E5
SFWTIHPSANRYLTL	FOXM1	306	Q08050
NLHPSTLTLTWQDQY	IL21R	41	Q9HBE5
VSLSPSIWVIFYNIH	CLDN12	146	P56749
SLIRIIWVNSPHYNT	DNAH2	366	Q9P225
VSTLNSLLNPVIYTW	S1PR2	276	O95136
QVQTLTSYLWSRHLP	METTL17	86	Q9H7H0
WRLQTLNGSHAYLTL	CDH16	716	O75309
LSYWHITLAVLRIPS	OR6B2	216	Q6IFH4
LIVSILRSWNEPLYH	PRL	111	P01236
YASQWTLNRPHPTIS	DSCAM	1746	O60469
VILLHWYSTVLNPTS	TAS2R20	61	P59543
WLPTNSNYSHVIFLN	RIMBP2	411	O15034
LLGTHSWLPYDRNIS	NBEAL2	2416	Q6ZNJ1
TQYQLLATHVPTVWA	RHOBTB2	41	Q9BYZ6
NLTHSLSLPWRPSTY	TEKT3	41	Q9BXF9
FLTPSRSSLYWALHN	TEFM	16	Q96QE5
TQYQLLATHVPTVWA	RHOBTB1	41	O94844
SLVWLIHSTLARYTQ	SLC35F4	51	A4IF30
LLTYLHWPLLDLTNS	CMTM1	71	Q8IZ96
LQQTLPWLRSTHSIY	C11orf42	146	Q8N5U0
DLSHILGIPQSWRLY	RNF213	661	Q63HN8
LVLSSPNSSILWLQY	PDCD11	1611	Q14690
ITPSLIRTNSKWYHL	STOX2	146	Q9P2F5
WTLNLPHRTQILYST	TRMT61A	76	Q96FX7
SVWRQLYPKHLSQSS	TMEM214	401	Q6NUQ4
LSWVLQNRVLSSSHP	SIGLEC10	286	Q96LC7
NYPWLTNHTVQLQLR	TMEM25	186	Q86YD3
WSNISLYSVVSLRPL	WDR36	691	Q8NI36
PSLYTSSHLLWTNRF	PPP1R12B	741	O60237