Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear speck	CCNL2 AKAP17A CCNL1 YLPM1 CIR1 TRIP12 PALB2	1.30e-04	431	55	7	GO:0016607
GeneOntologyCellularComponent	nuclear body	CCNL2 AKAP17A MTOR CCNL1 YLPM1 NUFIP2 CIR1 TRIP12 PALB2	5.35e-04	903	55	9	GO:0016604
MousePheno	abnormal placenta labyrinth morphology	HOXA13 ESRRB CIR1 FRYL TRIP12 PALB2	3.01e-05	194	44	6	MP:0001716
Domain	CYCLIN	CCNL2 RBL1 CCNL1	1.89e-04	38	55	3	SM00385
Domain	-	CCNL2 RBL1 CCNL1	2.21e-04	40	55	3	1.10.472.10
Domain	Cyclin_L/T	CCNL2 CCNL1	2.36e-04	8	55	2	IPR015429
Domain	Cyclin-like	CCNL2 RBL1 CCNL1	2.74e-04	43	55	3	IPR013763
Domain	Cyclin_C	CCNL2 CCNL1	1.13e-03	17	55	2	PF02984
Domain	Cyclin_C-dom	CCNL2 CCNL1	1.13e-03	17	55	2	IPR004367
Domain	Cyclin_C	CCNL2 CCNL1	1.13e-03	17	55	2	SM01332
Domain	JmjC	PHF2 JMJD1C	2.25e-03	24	55	2	PF02373
Domain	C2H2_Znf_fam	PEG3 ZNF770	2.25e-03	24	55	2	IPR027775
Domain	CYCLINS	CCNL2 CCNL1	3.06e-03	28	55	2	PS00292
Domain	JMJC	PHF2 JMJD1C	3.99e-03	32	55	2	PS51184
Domain	JmjC_dom	PHF2 JMJD1C	3.99e-03	32	55	2	IPR003347
Domain	JmjC	PHF2 JMJD1C	4.24e-03	33	55	2	SM00558
Domain	Cyclin_N	CCNL2 CCNL1	4.24e-03	33	55	2	IPR006671
Domain	Cyclin_N	CCNL2 CCNL1	4.24e-03	33	55	2	PF00134
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	PTPN13 CCDC88A NUFIP2 ROBO1 MCM3 MICAL3 MAP3K21 SMCR8 JMJD1C	1.84e-06	708	56	9	39231216
Pubmed	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis.	MTOR JMJD1C	2.55e-06	2	56	2	32034158
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PHF2 HOXA13 YLPM1 NUFIP2 KRI1 MCM3 DDX3Y CHD1 TRIP12 JMJD1C	2.61e-06	954	56	10	36373674
Pubmed	Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.	CCNL2 CCNL1	7.63e-06	3	56	2	18216018
Pubmed	F-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs.	CCDC88A MTOR	7.63e-06	3	56	2	27666957
Pubmed	CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.	CCNL2 CCNL1	7.63e-06	3	56	2	17261272
Pubmed	The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development.	BCL11B ROBO1	7.63e-06	3	56	2	21060114
Pubmed	Characterization of cyclin L1 as an immobile component of the splicing factor compartment.	CCNL2 CCNL1	7.63e-06	3	56	2	17494991
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PLEKHG1 PTPN13 CCDC88A MTOR CNKSR3 FRYL ATAT1 MAP3K21 TRIP12	8.95e-06	861	56	9	36931259
Pubmed	CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.	CCNL2 CCNL1	1.52e-05	4	56	2	24436071
Pubmed	Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.	CCNL2 CCNL1	1.52e-05	4	56	2	2217177
Pubmed	Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.	MTOR TWIST2	1.52e-05	4	56	2	27768862
Pubmed	Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.	RNF123 KMT5A DNAJB2 JMJD1C	1.65e-05	94	56	4	25201988
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	CACNB1 BCL11B CCDC88A RBL1 MCM3 PALB2 SMG6	1.81e-05	513	56	7	25798074
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNB1 BCL11B CCDC88A MTOR CNKSR3 YLPM1 NUFIP2 MCM3 SMG6	2.17e-05	963	56	9	28671696
Pubmed	Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.	CCNL2 CCNL1	2.54e-05	5	56	2	11683997
Pubmed	CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.	CCNL2 CCNL1	2.54e-05	5	56	2	17516030
Pubmed	Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling.	MTOR SMCR8	2.54e-05	5	56	2	27875531
Pubmed	Spatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina.	HOXA13 TWIST2	5.32e-05	7	56	2	27821748
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PHF2 KMT5A CCNL1 ZNF770 CHD1 TRIP12 JMJD1C	5.32e-05	608	56	7	36089195
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	CCDC88A NUFIP2 KRI1 ROBO1 JMJD1C	5.84e-05	256	56	5	33397691
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PTPN13 CCDC88A ARFGAP3 NUFIP2 JMJD1C	6.64e-05	263	56	5	34702444
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	PHF2 KMT5A JMJD1C	6.91e-05	49	56	3	34368113
Pubmed	Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies.	HOXA13 TWIST2	7.09e-05	8	56	2	26598695
Pubmed	A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.	RBL1 MCM3	7.09e-05	8	56	2	24662053
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTOR YLPM1 NUFIP2 KRI1 CHD1 FRYL TRIP12	8.32e-05	653	56	7	22586326
Pubmed	Comprehensive interactome of Otx2 in the adult mouse neural retina.	ZNF22 ESRRB TRIP12	8.75e-05	53	56	3	26426291
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CCNL2 CCNL1	9.10e-05	9	56	2	14623875
Pubmed	RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.	ESRRB NUFIP2 MCM3 TRIP12	9.24e-05	146	56	4	21589869
Pubmed	Cell Type-Specific Role of RNA Nuclease SMG6 in Neurogenesis.	BCL11B SMG6	1.39e-04	11	56	2	34943873
Pubmed	Roundabout receptors are critical for foregut separation from the body wall.	ROBO1 TWIST2	1.66e-04	12	56	2	23328398
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CCDC88A ARFGAP3 YLPM1 NUFIP2 ROBO1 CHD1 JMJD1C	1.70e-04	733	56	7	34672954
Pubmed	NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.	MCM3 PALB2	1.96e-04	13	56	2	28416489
Pubmed	The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.	TRIP12 PALB2	1.96e-04	13	56	2	29499138
Pubmed	mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis.	BCL11B MTOR	1.96e-04	13	56	2	27993979
Pubmed	Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.	ADAMTS14 PALB2	2.29e-04	14	56	2	21254220
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	PTPN13 CCDC88A ARFGAP3 ROBO1 MCM3 SMCR8 TRIP12	2.42e-04	777	56	7	35844135
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	HOXA13 BCL11B NUFIP2 KRI1 TRIP12	2.48e-04	349	56	5	25665578
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHF2 PTPN13 CCDC88A YLPM1 NUFIP2 KRI1 ROBO1 MICAL3	2.62e-04	1049	56	8	27880917
Pubmed	p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.	MCM3 PALB2	2.64e-04	15	56	2	30126895
Pubmed	Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.	BCL11B MTOR	3.01e-04	16	56	2	36440598
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PHF2 AKAP17A PEG3 YLPM1 NUFIP2 KRI1 DDX3Y TRIP12 ITIH3	3.19e-04	1371	56	9	36244648
Pubmed	Geminin is required for Hox gene regulation to pattern the developing limb.	HOXA13 TWIST2	3.41e-04	17	56	2	32450229
Pubmed	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.	BCL11B CNKSR3 ROBO1 ATAT1 ITIH3	3.49e-04	376	56	5	24154525
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	PTPN13 CCDC88A ROBO1 MICAL3	3.64e-04	209	56	4	36779422
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	RNF123 YLPM1 MCM3	3.81e-04	87	56	3	17148452
Pubmed	Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.	BCL11B DDX3Y	3.83e-04	18	56	2	35762573
Pubmed	Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.	TRIP12 JMJD1C	3.83e-04	18	56	2	7776974
Pubmed	Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold.	BCL11B ROBO1	3.83e-04	18	56	2	32707082
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PLEKHG1 CCDC88A ARFGAP3 CNKSR3 KRI1 MCM3 MICAL3	4.25e-04	853	56	7	28718761
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	CCDC88A NUFIP2 ROBO1 MCM3 TRIP12	4.58e-04	399	56	5	37536630
Pubmed	Delineating a conserved genetic cassette promoting outgrowth of body appendages.	HOXA13 TWIST2	4.75e-04	20	56	2	23358455
Pubmed	FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.	BCL11B ROBO1	4.75e-04	20	56	2	30392794
Pubmed	HEY1 functions are regulated by its phosphorylation at Ser-68.	PTPN13 CCDC88A YLPM1	4.93e-04	95	56	3	27129302
Pubmed	Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis.	BCL11B MTOR	5.24e-04	21	56	2	23637172
Pubmed	Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.	BCL11B ROBO1	5.24e-04	21	56	2	23303943
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PHF2 NUFIP2 MICAL3 TRIP12 F5 PALB2	5.87e-04	645	56	6	25281560
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	ZNF22 YLPM1 NUFIP2 CIR1 ZNF770 CHD1	6.37e-04	655	56	6	35819319
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	CCNL2 AKAP17A CCNL1	6.42e-04	104	56	3	31365120
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	PLEKHG1 ZNF22 RBL1 CNKSR3 ROBO1 MCM3 CHD1	6.48e-04	916	56	7	32203420
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	PHF2 PTPN13 KMT5A YLPM1 ZCRB1 MCM3 MAP3K21	6.74e-04	922	56	7	27609421
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	PTPN13 CCDC88A ROBO1	6.78e-04	106	56	3	38891874
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	MED12L MICAL3	6.87e-04	24	56	2	24023788
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	PHF2 YLPM1 KRI1 MCM3	6.93e-04	248	56	4	27926873
Pubmed	CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.	ZNF22 ARFGAP3 MEIOB ZNF770 KATNAL1	7.12e-04	440	56	5	35156780
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	PHF2 CHD1 TRIP12 PALB2	7.14e-04	250	56	4	33536335
Pubmed	Genome-wide association analysis identifies 13 new risk loci for schizophrenia.	KMT5A ITIH3 SMG6	7.36e-04	109	56	3	23974872
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	PHF2 CHD1 TRIP12	7.36e-04	109	56	3	33554859
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PLEKHG1 PTPN13 KRI1 FRYL MAP3K21	7.57e-04	446	56	5	24255178
Pubmed	TRAIP regulates replication fork recovery and progression via PCNA.	KMT5A MCM3	8.71e-04	27	56	2	27462463
Pubmed	Robo1 modulates proliferation and neurogenesis in the developing neocortex.	BCL11B ROBO1	8.71e-04	27	56	2	24741061
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	CCNL2 TRIP12 JMJD1C	8.81e-04	116	56	3	30804394
Pubmed	Global gene expression analysis of murine limb development.	HOXA13 BCL11B PEG3	9.03e-04	117	56	3	22174793
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	BCL11B ATAT1	9.37e-04	28	56	2	31600191
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RNF123 PTPN13 AKAP17A PEG3 YLPM1 ROBO1 DNAJB2 TRIP12	9.98e-04	1285	56	8	35914814
Pubmed	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.	BCL11B ROBO1	1.01e-03	29	56	2	25336744
Pubmed	Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.	BCL11B MTOR	1.01e-03	29	56	2	26633882
Pubmed	Impaired Interneuron Development after Foxg1 Disruption.	BCL11B ROBO1	1.01e-03	29	56	2	26620267
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	YLPM1 NUFIP2 KRI1 MCM3 CHD1 TRIP12 JMJD1C	1.01e-03	989	56	7	36424410
Pubmed	Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.	BCL11B MTOR	1.08e-03	30	56	2	22056141
Pubmed	Senescence is a developmental mechanism that contributes to embryonic growth and patterning.	HOXA13 RBL1	1.08e-03	30	56	2	24238961
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	YLPM1 KRI1 TRIP12 JMJD1C	1.13e-03	283	56	4	30585729
Pubmed	Genome-wide meta-analysis for severe diabetic retinopathy.	CCNL1 MAP3K21	1.15e-03	31	56	2	21441570
Pubmed	The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.	BCL11B ROBO1	1.15e-03	31	56	2	29099309
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	PTPN13 CCDC88A MTOR RBL1 ARFGAP3 NUFIP2 MCM3 MAP3K21	1.19e-03	1321	56	8	27173435
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	BCL11B MCM3 FRYL	1.20e-03	129	56	3	23022380
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	CACNB1 CCDC88A ATAT1	1.28e-03	132	56	3	16944949
Pubmed	Keratin 13 deficiency causes white sponge nevus in mice.	CCNL2 CCNL1	1.30e-03	33	56	2	32758484
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	BCL11B PEG3 ROBO1	1.34e-03	134	56	3	19030180
Pubmed	Regulation of prefrontal patterning and connectivity by retinoic acid.	BCL11B ROBO1	1.38e-03	34	56	2	34599305
Pubmed	The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.	BCL11B ROBO1	1.38e-03	34	56	2	25631876
Pubmed	Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells.	BCL11B JMJD1C	1.38e-03	34	56	2	31569049
Pubmed	Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.	KRI1 F5	1.38e-03	34	56	2	12878157
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	BCL11B KMT5A ITIH3 SMG6	1.45e-03	303	56	4	25056061
Pubmed	Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.	BCL11B MTOR	1.46e-03	35	56	2	35858542
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CCNL1 YLPM1 MCM3 MICAL3 TRIP12 PALB2	1.50e-03	774	56	6	15302935
Interaction	RPSA2 interactions	ZNF22 CCNL1 ZCRB1 KRI1 ZNF770 TRIP12	3.97e-06	152	56	6	int:RPSA2
Interaction	YWHAG interactions	PLEKHG1 PTPN13 CCDC88A AKAP17A MTOR CNKSR3 NUFIP2 MCM3 FRYL ATAT1 MAP3K21 TRIP12 TGOLN2	2.87e-05	1248	56	13	int:YWHAG
Interaction	NEK4 interactions	CACNB1 BCL11B CCDC88A RBL1 MCM3 DNAJB2 PALB2 TGOLN2 SMG6	2.97e-05	582	56	9	int:NEK4
Cytoband	2q36.3	FBXO36 TRIP12	3.32e-04	22	56	2	2q36.3
GeneFamily	PHD finger proteins\|Lysine demethylases	PHF2 JMJD1C	1.03e-03	24	36	2	485
GeneFamily	Cyclins	CCNL2 CCNL1	1.41e-03	28	36	2	473
Coexpression	GSE3920_IFNA_VS_IFNG_TREATED_ENDOTHELIAL_CELL_UP	CCNL2 CCNL1 NUFIP2 DDX3Y FRYL DNAJB2	1.69e-06	170	56	6	M6697
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CCNL2 CCDC88A CCNL1 CIR1 KRI1 SMG6	1.77e-07	197	56	6	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNL1 NUFIP2 CHD1 FRYL TRIP12 JMJD1C	1.93e-07	200	56	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A CCNL1 NUFIP2 CHD1 JMJD1C	3.49e-06	184	56	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	CCNL1 NUFIP2 CHD1 JMJD1C SMG6	3.88e-06	188	56	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	facs-Skin-Anagen-3m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11B ROBO1 MCM3 DDX3Y ADAMTS14	4.30e-06	192	56	5	ec1fd2fb6e71f87189d66261909a84e2be63cacb
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	CCNL2 CCDC88A CCNL1 KRI1 TGOLN2	4.30e-06	192	56	5	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	BCL11B CCNL1 DDX3Y CHD1 JMJD1C	4.30e-06	192	56	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	CCDC88A CCNL1 DDX3Y JMJD1C TGOLN2	4.87e-06	197	56	5	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CACNB1 PTPN13 RBL1 PEG3	2.91e-05	140	56	4	0e1e9281de87df178ac41ed6b697b4fa09be2749
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BCL11B RBL1 F5 ITIH3	3.81e-05	150	56	4	c922dbb4c9c12ccf08bd5f6168b20606c605d052
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	CCNL1 CHD1 JMJD1C SMG6	4.44e-05	156	56	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HOXA13 CCDC88A MED12L MCM3	4.66e-05	158	56	4	f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BCL11B RELL2 RBL1 MCM3	5.79e-05	167	56	4	859dfe0764cb69de27e79e1c1aa65f9d538f79ea
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	BCL11B CCNL1 CHD1 JMJD1C	6.34e-05	171	56	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHF2 MTOR YLPM1 FRYL	6.78e-05	174	56	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A PEG3 NUFIP2 JMJD1C	7.09e-05	176	56	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	droplet-Marrow-nan-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF123 CIR1 DDX3Y DNAJB2	7.09e-05	176	56	4	f92063b72ebfeb9b192281dc63d6bf2759c78554
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	BCL11B CCNL1 DDX3Y JMJD1C	7.90e-05	181	56	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A CCNL1 CHD1 JMJD1C	8.60e-05	185	56	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	saliva-Severe-critical_progression_d28-40\|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCNL1 DDX3Y CHD1 JMJD1C	8.78e-05	186	56	4	0095560ca776b01aa473ad4d6015ed78fc93ff51
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CACNB1 MTOR SOCS4 F5	9.34e-05	189	56	4	99b01893da9f9f7c9528afaffad178285211738b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCNL1 CIR1 CHD1 JMJD1C	9.73e-05	191	56	4	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PEG3 CCNL1 DDX3Y CHD1	9.73e-05	191	56	4	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCNL1 DDX3Y CHD1 JMJD1C	9.92e-05	192	56	4	aee6522d25e012231cdb905ce047295cb64d6e82
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 SOCS4 MICAL3 JMJD1C	1.03e-04	194	56	4	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCNL1 DDX3Y CHD1 JMJD1C	1.03e-04	194	56	4	dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHF2 ZNF22 BCL11B DDX3Y	1.05e-04	195	56	4	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNL1 DDX3Y CHD1 JMJD1C	1.05e-04	195	56	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCDC88A CCNL1 DDX3Y JMJD1C	1.07e-04	196	56	4	5fe6534af65d43eeacd4b031310242b4f706008b
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	CCNL1 CIR1 CHD1 JMJD1C	1.10e-04	197	56	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCNL1 CIR1 CHD1 JMJD1C	1.12e-04	198	56	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCNL1 CIR1 CHD1 JMJD1C	1.12e-04	198	56	4	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	mLN-(1)_T_cell-(11)_Activated_CD4_T\|mLN / shred on region, Cell_type, and subtype	BCL11B DDX3Y CHD1 C8orf34	1.14e-04	199	56	4	7da5a38f36ee10b95e07b2a8275cfb80c891d54c
ToppCell	mLN-T_cell-Activated_CD4_T\|mLN / Region, Cell class and subclass	BCL11B DDX3Y CHD1 C8orf34	1.14e-04	199	56	4	398eb1c809afb6ec711fb41563e11a3697730271
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CACNB1 PTPN13 PEG3 KIAA1614	1.16e-04	200	56	4	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	CCNL1 CIR1 CHD1 JMJD1C	1.16e-04	200	56	4	62c25042086f1afd1102e0720e933c2e476468fd
Disease	cortical thickness	PLEKHG1 BCL11B CCDC88A CNKSR3 YLPM1 ROBO1 MICAL3 JMJD1C KIAA1614 SMG6	2.09e-05	1113	52	10	EFO_0004840
Disease	Tinnitus	PTPN13 BCL11B CNKSR3 C8orf34	8.27e-05	130	52	4	HP_0000360
Disease	triacylglycerol 58:12 measurement	FBXO36 TRIP12	1.99e-04	12	52	2	EFO_0010439
Disease	interferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement	F5 JMJD1C	3.60e-04	16	52	2	EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Disease	cortical surface area measurement	PLEKHG1 BCL11B CCDC88A CNKSR3 ROBO1 FRYL KIAA1614 TGOLN2 SMG6	5.18e-04	1345	52	9	EFO_0010736
Disease	neuroimaging measurement	PLEKHG1 BCL11B CCDC88A CNKSR3 ROBO1 FRYL JMJD1C SMG6	5.28e-04	1069	52	8	EFO_0004346
Disease	maximal midexpiratory flow rate	MED12L MICAL3	5.67e-04	20	52	2	EFO_0004313
Disease	prothrombin time measurement	F5 JMJD1C	6.26e-04	21	52	2	EFO_0008390
Disease	brain connectivity measurement	PLEKHG1 BCL11B CNKSR3 KIAA1614 SMG6	6.88e-04	400	52	5	EFO_0005210
Disease	lymphocyte count	BCL11B AKAP17A RBL1 KMT5A MED12L MICAL3 TRIP12 JMJD1C SMG6	9.48e-04	1464	52	9	EFO_0004587
Disease	inflammatory biomarker measurement	F5 JMJD1C	9.64e-04	26	52	2	EFO_0004872
Disease	cancer (implicated_via_orthology)	MTOR RBL1 ESRRB TRIP12	1.28e-03	268	52	4	DOID:162 (implicated_via_orthology)
Disease	Colorectal Carcinoma	CACNB1 BCL11B PEG3 CHD1 C8orf34 F5	1.43e-03	702	52	6	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRPGSAKRYSRSDKR	SMG6	236	Q86US8
LKTTGYSDRPTARRK	ARFGAP3	391	Q9NP61
YSKRKGRFKRSDGST	CACNB1	31	Q02641
EKSESKGTRRDFRSY	C8orf34	156	Q49A92
ALGKRFRKDAASYRS	C16orf78	91	Q8WTQ4
ASKSPYNGVRKDSKR	CCNL1	371	Q9UK58
SRKRPYSSFSNGKDH	CHD1	1571	O14646
DTERKRRHAKPGSYS	ADAMTS14	246	Q8WXS8
SVGEPKYFTTSDRRK	MEIOB	176	Q8N635
EKSSQKSRREPRTYT	MICAL3	1806	Q7RTP6
RKRRDFTSSGSRKLY	MCUR1	151	Q96AQ8
RKRKTKSSSRVDEYP	MED12L	1771	Q86YW9
KLTDFYPVRRSSRKS	KMT5A	221	Q9NQR1
RKAKRTYESGSESGD	JMJD1C	1616	Q15652
KPSYSRSKSISASGR	KIAA1109	3611	Q2LD37
SSRPKLGKSRSYSVE	KIAA1614	1016	Q5VZ46
SGKTPGDFYDRRTTK	CCDC88A	1736	Q3V6T2
ESYEYRPRSSTKSKG	FRYL	91	O94915
SLRSEYRSTKPGEAK	FBXO36	41	Q8NEA4
KTYPRSIASSVRRKD	KRI1	311	Q8N9T8
RSKRSAYPSTSRGLK	PEG3	276	Q9GZU2
RYTGKRKSACTPASD	PALB2	511	Q86YC2
RRKTRQPDAKDGDSY	MCM3	691	P25205
RPSSKEGRRSDTCEY	BCL11B	786	Q9C0K0
PRSASADDIKKAYRR	DNAJB2	11	P25686
YSRSPSRSASPKRRK	CCNL2	391	Q96S94
KRAEGDIKPYSSSDR	ATAT1	226	Q5SQI0
GRQKYKRRLDSESSP	ESRRB	181	O95718
KDAYSSFGSRDSRGK	DDX3Y	66	O15523
VRTSTTPRKKEARYS	PTPN13	331	Q12923
TPRKKEARYSDGSIA	PTPN13	336	Q12923
TKGNKRSRTRTDSYS	MTOR	2436	P42345
EKPSTSRDKDYRARG	KATNAL1	146	Q9BW62
KKGYRCRTSRGSEPD	RELL2	41	Q8NC24
SRSKKRKGSDDAPYS	PHF2	891	O75151
RKYLDSTFTKRDPRG	F5	1621	P12259
SRSPQRKKTESALYG	MAP3K21	711	Q5TCX8
SKSGKPRRARTAFTY	NKX1-1	291	Q15270
ERYSSPTAGSAKRRL	RBL1	646	P28749
DKRGSPDSKTRKTYF	ITIH3	696	Q06033
PKTSRSRSADRKDGY	SOCS4	16	Q8WXH5
SHPSDASSYRRGRKK	HOXA13	311	P31271
SAYPAGLSSDRHKKR	SMCR8	691	Q8TEV9
KHAYKDDSPRRRSTS	AKAP17A	626	Q02040
RSRSPGSYKQRETRK	CIR1	391	Q86X95
SRRKSPAYDGNTSRK	CNK3/IPCEF1	101	G9CGD6
SRRKSPAYDGNTSRK	CNKSR3	101	Q6P9H4
GKRSKVTRRPKASDY	TGOLN2	416	O43493
SGYTTPKKRKARRNS	NUFIP2	216	Q7Z417
KSYGRPRTSNRERSD	SRRM5	171	B3KS81
KQSGYSRPRASSKEK	SRRM5	601	B3KS81
SRKSYRLTSDAEKSR	RNF123	11	Q5XPI4
ARTDRSSDRKGSSYK	ROBO1	1516	Q9Y6N7
SSDRKGSSYKGREVL	ROBO1	1521	Q9Y6N7
SYRDKKDHSSSRRGG	YLPM1	1746	P49750
AARSGKIPSRFKRSY	ZNF770	316	Q6IQ21
SSFSRLRRSLDDKPY	ZNF22	41	P17026
DDSRRPRIKKSTYFS	ZCRB1	196	Q8TBF4
SKEGSAPYRLRRKSE	PLEKHG1	456	Q9ULL1
KDNSRGVKRSASPDY	TRIP12	66	Q14669
RKRRYSKKSSEDGSP	TWIST2	31	Q8WVJ9