Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Sec23/24_helical_dom	SEC23B SEC23A	1.18e-04	6	53	2	IPR006900
Domain	Sec23_24_beta_S	SEC23B SEC23A	1.18e-04	6	53	2	IPR012990
Domain	zf-Sec23_Sec24	SEC23B SEC23A	1.18e-04	6	53	2	PF04810
Domain	Sec23_trunk	SEC23B SEC23A	1.18e-04	6	53	2	PF04811
Domain	Sec23_helical	SEC23B SEC23A	1.18e-04	6	53	2	PF04815
Domain	Sec23_BS	SEC23B SEC23A	1.18e-04	6	53	2	PF08033
Domain	Sec23/24_trunk_dom	SEC23B SEC23A	1.18e-04	6	53	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC23B SEC23A	1.18e-04	6	53	2	IPR006895
Domain	Gelsolin	SEC23B SEC23A	7.03e-04	14	53	2	PF00626
Domain	Gelsolin-like_dom	SEC23B SEC23A	7.03e-04	14	53	2	IPR007123
Domain	-	XRCC6 SEC23B SEC23A	1.21e-03	74	53	3	3.40.50.410
Domain	ADF-H/Gelsolin-like_dom	SEC23B SEC23A	2.10e-03	24	53	2	IPR029006
Domain	-	SEC23B SEC23A	2.10e-03	24	53	2	3.40.20.10
Domain	VWF_A	XRCC6 SEC23B SEC23A	2.79e-03	99	53	3	IPR002035
Domain	ZnF_U1	TUT7 ZFHX2	3.05e-03	29	53	2	SM00451
Domain	Znf_U1	TUT7 ZFHX2	3.05e-03	29	53	2	IPR003604
Domain	Helicase_C	RECQL4 SNRNP200 RAD54L	3.48e-03	107	53	3	PF00271
Domain	HELICc	RECQL4 SNRNP200 RAD54L	3.48e-03	107	53	3	SM00490
Domain	Helicase_C	RECQL4 SNRNP200 RAD54L	3.57e-03	108	53	3	IPR001650
Domain	HELICASE_CTER	RECQL4 SNRNP200 RAD54L	3.66e-03	109	53	3	PS51194
Domain	HELICASE_ATP_BIND_1	RECQL4 SNRNP200 RAD54L	3.66e-03	109	53	3	PS51192
Domain	DEXDc	RECQL4 SNRNP200 RAD54L	3.66e-03	109	53	3	SM00487
Domain	Helicase_ATP-bd	RECQL4 SNRNP200 RAD54L	3.76e-03	110	53	3	IPR014001
Pubmed	Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.	SEC23B SEC23A	2.55e-06	2	56	2	30065114
Pubmed	Cloning and functional characterization of mammalian homologues of the COPII component Sec23.	SEC23B SEC23A	2.55e-06	2	56	2	8898360
Pubmed	RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.	RECQL4 XRCC6	7.63e-06	3	56	2	24942867
Pubmed	Defective FANCI binding by a fanconi anemia-related FANCD2 mutant.	FANCI FANCL	7.63e-06	3	56	2	25489943
Pubmed	FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.	FANCI FANCL	7.63e-06	3	56	2	19589784
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	NFIC FANCI RECQL4 FANCL MED13L ATP2B1 XRCC6	8.12e-06	453	56	7	29656893
Pubmed	Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.	FANCI FANCL	1.52e-05	4	56	2	19111657
Pubmed	Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.	XRCC6 RAD54L	1.52e-05	4	56	2	20150414
Pubmed	Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.	FANCI FANCL	1.52e-05	4	56	2	24623813
Pubmed	Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.	FANCI FANCL	1.52e-05	4	56	2	21775430
Pubmed	Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.	FANCI FANCL	1.52e-05	4	56	2	33686268
Pubmed	TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.	SEC23B SEC23A	1.52e-05	4	56	2	27551091
Pubmed	ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.	SEC23B SEC23A	1.52e-05	4	56	2	24069399
Pubmed	Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.	FANCI FANCL	1.52e-05	4	56	2	19737859
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SCAF8 ZFHX2 MINAR1 MED13L	2.46e-05	104	56	4	10470851
Pubmed	Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.	XRCC6 RAD54L	2.54e-05	5	56	2	12186839
Pubmed	Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.	FANCI FANCL	2.54e-05	5	56	2	36385258
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZNF274 FANCI UTP4 ATP2B1 USP19 RAD54L	2.59e-05	363	56	6	14691545
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CUX2 WASF3 MINAR1 MED13L SNRNP200	3.16e-05	225	56	5	12168954
Pubmed	Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1.	SEC23B SEC23A	3.80e-05	6	56	2	15642376
Pubmed	Sec24 proteins and sorting at the endoplasmic reticulum.	SEC23B SEC23A	3.80e-05	6	56	2	10075675
Pubmed	Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA.	FANCI FANCL	3.80e-05	6	56	2	32510829
Pubmed	A family of mammalian proteins homologous to yeast Sec24p.	SEC23B SEC23A	3.80e-05	6	56	2	10329445
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SCAF8 FANCI MAP2K2 SNRNP200 XRCC6 SEC23B SEC23A	4.04e-05	582	56	7	20467437
Pubmed	Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.	FANCI FANCL	5.32e-05	7	56	2	30456385
Pubmed	Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice.	SEC23B SEC23A	7.09e-05	8	56	2	27297878
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MARS1 FANCI MAP2K2 SNRNP200 XRCC6 SEC23A USP19	7.20e-05	638	56	7	33239621
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	MARS1 FANCI TMEM199 MAP2K2 ATP2B1 XRCC6 SEC23A USP19	7.77e-05	878	56	8	37223481
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FANCI UTP4 TUT7 SNRNP200 XRCC6 SEC23B SEC23A	8.32e-05	653	56	7	22586326
Pubmed	Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin.	FANCI FANCL	9.10e-05	9	56	2	32092106
Pubmed	Comprehensive analysis of DNA repair gene variants and risk of meningioma.	RECQL4 FANCL RAD54L	1.09e-04	57	56	3	18270339
Pubmed	An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.	SNRNP200 USP19	1.14e-04	10	56	2	23500468
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	VPS37A SCAF8 MARS1 NFIC WASF3 STAP2 ZFHX2 MAP2K2 ADARB1 ATP2B1	1.18e-04	1489	56	10	28611215
Pubmed	Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.	VPS37A RABGEF1 CBLB	1.27e-04	60	56	3	34761192
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	ATP2B1 XRCC6 SEC23B SEC23A	1.35e-04	161	56	4	32572027
Pubmed	The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.	FANCI FANCL	1.39e-04	11	56	2	19965384
Pubmed	Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.	SEC23B SEC23A	1.39e-04	11	56	2	19966784
Pubmed	Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response.	FANCI FANCL	1.39e-04	11	56	2	26625197
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MTMR4 TUT7 PLA2G4F MAP2K2 ATP2B1 SEC23B SEC23A	1.66e-04	730	56	7	34857952
Pubmed	Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.	FANCI FANCL	1.96e-04	13	56	2	27986371
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SCAF8 NFIC MAP2K2 ADARB1 SNRNP200 XRCC6 USP19	2.37e-04	774	56	7	15302935
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MARS1 FANCI UTP4 TUT7 RECQL4 ATP2B1 SNRNP200 XRCC6 SEC23A	2.89e-04	1353	56	9	29467282
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	MARS1 FANCI SNRNP200 XRCC6	2.91e-04	197	56	4	31620119
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	NRXN3 FANCL MPP7	3.56e-04	85	56	3	23055939
Pubmed	Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice.	SEC23B SEC23A	5.24e-04	21	56	2	26494538
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	MED13L ATP2B1	5.24e-04	21	56	2	25249183
Pubmed	SEC23B is required for the maintenance of murine professional secretory tissues.	SEC23B SEC23A	5.76e-04	22	56	2	22745161
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	SEC23B SEC23A	5.76e-04	22	56	2	35120648
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	UTP4 TUT7 APOOL TMEM199 SYBU XRCC6 SEC23B SEC23A USP19	6.01e-04	1496	56	9	32877691
Pubmed	Fanconi Anemia	FANCI FANCL	6.30e-04	23	56	2	20301575
Pubmed	Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.	AHI1 NRXN3 ADARB1 SEC23A	7.03e-04	249	56	4	9371744
Pubmed	Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.	CUX2 ADARB1	7.46e-04	25	56	2	28288114
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	XRCC6 RAD54L	8.71e-04	27	56	2	20610542
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	MARS1 FANCI ATP2B1 SNRNP200 XRCC6 MPP7	9.53e-04	708	56	6	39231216
Pubmed	VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma.	XRCC6 SEC23B SEC23A	1.02e-03	122	56	3	36929488
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	VPS37A RABGEF1 CBLB XRCC6 USP19	1.06e-03	481	56	5	28190767
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	MARS1 ATP2B1 SNRNP200 XRCC6 SEC23B SEC23A	1.08e-03	725	56	6	27025967
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	MARS1 FANCI SNRNP200 XRCC6	1.10e-03	281	56	4	30455355
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	MARS1 UTP4 RECQL4 SNRNP200 XRCC6	1.11e-03	486	56	5	30940648
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	MARS1 SNRNP200 XRCC6 SEC23B SEC23A	1.19e-03	494	56	5	26831064
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	MARS1 SNRNP200 XRCC6 SEC23B	1.47e-03	304	56	4	32235678
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCI FANCL	7.16e-04	20	36	2	548
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_500	ENKUR FANCI UTP4 DENND2C WASF3 TMEM199 XRCC6 RAD54L	5.67e-06	387	54	8	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_500_k-means-cluster#3	CUX2 NRXN3 GPR50 TAGLN3 ZFHX2	1.24e-05	118	54	5	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_500_K3
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_500	ENKUR UTP4 WASF3 TMEM199 RAD54L	3.03e-05	142	54	5	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k3_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_500	FANCI UTP4 DENND2C WASF3 TMEM199 XRCC6 RAD54L	7.24e-05	406	54	7	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#4_top-relative-expression-ranked_500	ENKUR UTP4 DENND2C TMEM199	1.09e-04	97	54	4	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k4_500
Disease	congenital dyserythropoietic anemia type II (implicated_via_orthology)	SEC23B SEC23A	3.54e-06	2	56	2	DOID:0111401 (implicated_via_orthology)
Disease	craniolenticulosutural dysplasia (implicated_via_orthology)	SEC23B SEC23A	3.54e-06	2	56	2	DOID:0070307 (implicated_via_orthology)
Disease	Roberts syndrome (implicated_via_orthology)	SEC23B SEC23A	2.12e-05	4	56	2	DOID:5325 (implicated_via_orthology)
Disease	Fanconi anemia	FANCI FANCL	3.17e-04	14	56	2	cv:C0015625
Disease	syndrome (implicated_via_orthology)	SCAF8 APOOL	5.31e-04	18	56	2	DOID:225 (implicated_via_orthology)
Disease	Bone marrow hypocellularity	FANCI FANCL	5.31e-04	18	56	2	C1855710
Disease	mean arterial pressure, alcohol drinking	CUX2 C6orf89 ATP2B1	8.67e-04	98	56	3	EFO_0004329, EFO_0006340
Disease	Fanconi Anemia	FANCI FANCL	1.03e-03	25	56	2	C0015625
Disease	Acute monocytic leukemia	FANCI FANCL	1.12e-03	26	56	2	C0023465
Disease	Pancytopenia	FANCI FANCL	1.12e-03	26	56	2	C0030312
Disease	hypertension, COVID-19	CUX2 ATP2B1	1.20e-03	27	56	2	EFO_0000537, MONDO_0100096
Disease	Miller Dieker syndrome	FANCI FANCL	1.39e-03	29	56	2	C0265219
Disease	coffee consumption	CUX2 C6orf89	1.69e-03	32	56	2	EFO_0004330
Disease	mean arterial pressure, unipolar depression	CHODL ATP2B1	1.69e-03	32	56	2	EFO_0003761, EFO_0006340
Disease	Abnormality of radial ray	FANCI FANCL	1.80e-03	33	56	2	C4228778
Disease	systolic blood pressure, alcohol drinking	CUX2 C6orf89 ATP2B1	1.87e-03	128	56	3	EFO_0004329, EFO_0006335

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYQELPPEIKERSPP	AHI1	1111	Q8N157
LPEPAKPPAKYLQDL	ALX3	61	O95076
LKPTVPPLTPEQYEL	CUX2	876	O14529
PEPEAIPPNILSYLV	ATP2B1	501	P20020
LLDYIVNEPPPKLPN	MAP2K2	321	P36507
DPLEKDALVLYEPPP	RAD54L	111	Q92698
YPLEIKPPNQPLAAI	RABGEF1	456	Q9UJ41
ENDKLPPPLQPQVYA	RABGEF1	476	Q9UJ41
LKQFYEPKPDLLPPL	FANCI	631	Q9NVI1
KQPQLQPLHFLDPLP	MED13L	686	Q71F56
FDLIPLLPLPKPLQN	ASB18	441	Q6ZVZ8
LPEQPYLQPPLSILV	FER1L4	996	A9Z1Z3
CKLPQPEYPPALIIF	GPR50	16	Q13585
QLKNSPPYILDILPD	CBLB	66	Q13191
QKNYDPVLPPMPEDI	MPP7	116	Q5T2T1
GAYEKPQLLPLQPPT	PLA2G4F	211	Q68DD2
NIEDLPPLYTLNKPL	ADARB1	606	P78563
PFYQLLAEKALPLPP	MEIOSIN	621	C9JSJ3
DNLKEYLLVPLPPSP	NPIPB15	296	A6NHN6
KLPIPDQQLYDPVLV	MTMR4	1151	Q9NYA4
LPEQGPQDVPLLYLK	GFOD2	291	Q3B7J2
PTKENPYEDIPVQPL	DENND2C	316	Q68D51
YNLIPSDLKEPPQPP	ENKUR	11	Q8TC29
PLYPINTPDQKEIVP	ENAM	636	Q9NRM1
QLLEKNEPQRPPPQY	C6orf89	41	Q6UWU4
PPIPVQNDPELYEKL	SCAF8	1226	Q9UPN6
PPKELRQDPPILQVL	LRRC43	551	Q8N309
VKPEQLPIYTAPPLQ	APOOL	36	Q6UXV4
RPTYLVPKDQQPILP	MINAR1	411	Q9UPX6
LNKFLENPELYVPPL	AK9	1681	Q5TCS8
LPLPNDKTLLYNPFP	UTP4	611	Q969X6
KLPPLPPLPNQEENY	STAP2	296	Q9UGK3
INSLYPPGQEPIPKI	TAGLN3	66	Q9UI15
KNRQELYALPPPPQF	FANCL	96	Q9NW38
ERPVPKYPPQEAEQL	RECQL4	871	O94761
KPQPDIVLLPLPTAY	NRXN3	501	Q9HDB5
YPPHLNPQDPLKDLV	NFIC	396	P08651
KERPDLPPIQYEPVL	SEC23A	46	Q15436
KERPDLPPVQYEPVL	SEC23B	46	Q15437
EPEINPTAPVEKPYL	CHODL	181	Q9H9P2
LKPPPIKLYRETNEP	XRCC6	281	P12956
IQPIPCKPVEYPLQL	SOX13	251	Q9UN79
YLPEVVKPPRNPELV	TMEM199	86	Q8N511
YLPVPLPQKQKVLPV	USP19	671	O94966
PPFPLVPESLLKLQQ	ZFHX2	1346	Q9C0A1
LPEGLPPTLQPEYLQ	REPS2	356	Q8NFH8
PPNPEQYLTPLQQKE	SYBU	261	Q9NX95
RPKLQPEPLSYPVLE	TIE1	821	P35590
PVLNDLPQYMPPDFL	STPG4	91	Q8N801
EYPELQLDPKLDPLP	ZNF274	86	Q96GC6
NQSDKPPPLNILTPY	WASF3	126	Q9UPY6
LPEKYPPPTELLDLQ	SNRNP200	1291	O75643
DPKYPVENLLNPDSP	XNDC1N	16	Q6ZNB5
VYILEPGDPPLLQQP	ZNF800	21	Q2TB10
QLEPLPPLTPKFLNI	TUT7	986	Q5VYS8
LALRPYLQKQPQPSP	MARS1	196	P56192
NILLPPQFPQEKPVI	VPS37A	66	Q8NEZ2