Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

EMILIN2 MMRN1 ELN

7.39e-05121423GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

EMILIN2 MMRN1 ELN

1.21e-04141423GO:0097493
HumanPhenoLong palpebral fissure

WARS1 SPTBN1 RFX7 KMT2D KMT2A TAF4 CUX1

1.02e-0571567HP:0000637
HumanPhenoJoint hypermobility

CEP104 FLNB DPYD BICRA SPTBN1 NSD1 PTPN22 RFX7 BBS9 FOCAD PIGT PTPN11 KMT2D KMT2A ELN TAF4 VPS37D KIF22

1.49e-055575618HP:0001382
HumanPhenoAbnormal nasal bridge morphology

CEP104 TPO FLNB DPYD MAGEL2 WARS1 DYNC2H1 BICRA NEXMIF SPTBN1 GATA4 NSD1 RFX7 BBS9 CASZ1 FOCAD PIGT PTPN11 KMT2D MED12L KMT2A ELN TAF4 FH VPS37D

2.78e-0510295625HP:0000422
HumanPhenoLarge earlobe

DPYD WARS1 BICRA KMT2D ELN

4.46e-0537565HP:0009748
HumanPhenoDilatation of the renal pelvis

DYNC2H1 NSD1 XDH PTPN22 RFX7 BBS9 CASZ1 GREB1L FOCAD PTPN11 KMT2D FH

5.37e-052905612HP:0010946
HumanPhenoHeart murmur

BICRA SPTBN1 GATA4 FOCAD ELN

5.80e-0539565HP:0030148
HumanPhenoAbnormal eating behavior

DPYD MAGEL2 NEXMIF PTPN22 RFX7 BBS9 CASZ1 TAF4

6.58e-05128568HP:0100738
HumanPhenoAbnormal renal pelvis morphology

DYNC2H1 NSD1 XDH PTPN22 RFX7 BBS9 CASZ1 GREB1L FOCAD PTPN11 KMT2D FH

7.48e-053005612HP:0010944
HumanPhenoAbnormal heart sound

BICRA SPTBN1 GATA4 FOCAD ELN

8.36e-0542565HP:0031657
HumanPhenoAbnormality of the chin

MAGEL2 DYM BICRA NEXMIF SPTBN1 NSD1 RFX7 CASZ1 PTPN11 KMT2D MED12L ELN TAF4 VPS37D

9.36e-054095614HP:0000306
HumanPhenoVascular dilatation

FLNB SPTBN1 NSD1 PTPN22 CASZ1 FOCAD PTPN11 ELN TAF4 VPS37D

9.41e-052155610HP:0002617
HumanPhenoIrregular ossification of the humeral epiphyses

FLNB DYM

1.19e-042562HP:0003897
HumanPhenoAbnormal humeral ossification

FLNB DYM

1.19e-042562HP:0012791
HumanPhenoFrontal bossing

FLNB MAGEL2 DYNC2H1 BICRA SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD PIGT PTPN11 KMT2D MED12L KMT2A ELN FH CUX1 VPS37D

1.95e-047385619HP:0002007
HumanPhenoAbnormal shape of the frontal region

FLNB MAGEL2 DYNC2H1 BICRA SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD PIGT PTPN11 KMT2D MED12L KMT2A ELN FH CUX1 VPS37D

2.06e-047415619HP:0011218
HumanPhenoAbnormal frontal bone morphology

FLNB MAGEL2 DYNC2H1 BICRA SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD PIGT PTPN11 KMT2D MED12L KMT2A ELN FH CUX1 VPS37D

2.10e-047425619HP:0430000
HumanPhenoEpiphyseal dysplasia

FLNB DPYD DYM KIF22

2.54e-0429564HP:0002656
HumanPhenoNeoplasm of the middle ear

NSD1 FOCAD KMT2D

2.58e-0412563HP:0100799
HumanPhenoCholesteatoma

NSD1 FOCAD KMT2D

2.58e-0412563HP:0009797
HumanPhenoAbnormal ureter physiology

WARS1 NSD1 PTPN22 BBS9 GREB1L PIGT KMT2D ELN VPS37D KNL1

2.77e-042455610HP:0025634
HumanPhenoAbnormal morphology of ulna

FLNB MAGEL2 DYNC2H1 BICRA PIGT PTPN11 ELN VPS37D

3.00e-04159568HP:0040071
HumanPhenoAbnormality of the ulna

FLNB MAGEL2 DYNC2H1 BICRA PIGT PTPN11 ELN VPS37D

3.00e-04159568HP:0002997
HumanPhenoAplasia/Hypoplasia involving the nose

FLNB DPYD BICRA NEXMIF SPTBN1 GATA4 RFX7 PIGT KMT2D KMT2A ELN TAF4 VPS37D

3.03e-044015613HP:0009924
HumanPhenoAbnormal size of the palpebral fissures

MAGEL2 WARS1 BICRA SPTBN1 RFX7 KMT2D KMT2A ELN TAF4 CUX1 VPS37D

3.18e-042985611HP:0200007
HumanPhenoSelf-biting

CEP104 NEXMIF RFX7

3.33e-0413563HP:0012169
HumanPhenoSystolic heart murmur

GATA4 FOCAD ELN

3.33e-0413563HP:0031664
HumanPhenoNeonatal short-trunk short stature

FLNB KIF22

3.54e-043562HP:0008857
HumanPhenoLong phalanx of finger

NSD1 KIF22

3.54e-043562HP:0006155
HumanPhenoLarge joint dislocations

FLNB KIF22

3.54e-043562HP:0005008
HumanPhenoAbnormal upper lip morphology

FLNB DPYD MAGEL2 DYM WARS1 DYNC2H1 NEXMIF SPTBN1 NSD1 RFX7 BBS9 CASZ1 GREB1L PIGT KMT2D MED12L KMT2A ELN TAF4 CUX1 VPS37D KNL1

3.75e-049805622HP:0000177
HumanPhenoHigh forehead

SPTBN1 GATA4 NSD1 FOCAD PIGT PTPN11 KMT2D MED12L KMT2A ELN VPS37D

4.00e-043065611HP:0000348
HumanPhenoAbnormal external nose morphology

CEP104 FLNB DPYD BICRA NEXMIF SPTBN1 NSD1 RFX7 CASZ1 GREB1L FOCAD PIGT PTPN11 KMT2D MED12L KMT2A ELN TAF4 FH CUX1 KNL1

4.10e-049165621HP:0010938
HumanPhenoUreteral stenosis

NSD1 PTPN22 PIGT KMT2D

4.23e-0433564HP:0000071
HumanPhenoAortic dilatation

FLNB SPTBN1 NSD1 PTPN22 CASZ1 ELN TAF4 VPS37D

4.36e-04168568HP:0001724
HumanPhenoAortic aneurysm

FLNB SPTBN1 NSD1 PTPN22 CASZ1 ELN TAF4 VPS37D

4.36e-04168568HP:0004942
HumanPhenoFacial edema

TPO SPTBN1 PTPN22 TGFBI MED12L ELN VPS37D

4.68e-04129567HP:0000282
HumanPhenoHydronephrosis

DYNC2H1 NSD1 XDH PTPN22 RFX7 BBS9 CASZ1 GREB1L FOCAD KMT2D

5.05e-042645610HP:0000126
HumanPhenoDolichocephaly

MAGEL2 DYM BICRA SPTBN1 GATA4 NSD1 RFX7 KMT2D KMT2A

5.52e-04219569HP:0000268
HumanPhenoDisinhibition

CEP104 DPYD ABCA2 MAGEL2 DYM SPR NEXMIF SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD MED12L KMT2A ELN TAF4 VPS37D KNL1

6.30e-048075619HP:0000734
HumanPhenoInappropriate behavior

CEP104 DPYD ABCA2 MAGEL2 DYM SPR NEXMIF SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD MED12L KMT2A ELN TAF4 VPS37D KNL1

6.30e-048075619HP:0000719
HumanPhenoAbnormal response to social norms

CEP104 DPYD ABCA2 MAGEL2 DYM SPR NEXMIF SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD MED12L KMT2A ELN TAF4 VPS37D KNL1

6.30e-048075619HP:5200123
HumanPhenoSocial disinhibition

CEP104 DPYD ABCA2 MAGEL2 DYM SPR NEXMIF SPTBN1 GATA4 NSD1 RFX7 CASZ1 FOCAD MED12L KMT2A ELN TAF4 VPS37D KNL1

6.30e-048075619HP:5200029
HumanPhenoShort nose

FLNB DPYD NEXMIF SPTBN1 GATA4 RFX7 PIGT KMT2D KMT2A ELN VPS37D

6.68e-043255611HP:0003196
HumanPhenoAbnormality of the palpebral fissures

DPYD MAGEL2 WARS1 BICRA NEXMIF SPTBN1 GATA4 NSD1 RFX7 BBS9 PIGT PTPN11 KMT2D MED12L KMT2A ELN TAF4 CUX1 VPS37D KNL1

6.79e-048805620HP:0008050
HumanPhenoAbnormal morphology of bones of the upper limbs

FLNB MAGEL2 DYM DYNC2H1 BICRA GATA4 NSD1 PTPN22 PIGT PTPN11 ELN VPS37D KIF22

6.83e-044365613HP:0040065
HumanPhenoAbnormality of the humeral epiphysis

FLNB DYM

7.02e-044562HP:0003891
HumanPhenoLong metacarpals

NSD1 KIF22

7.02e-044562HP:0010493
HumanPhenoShort-trunked dwarfism

FLNB KIF22

7.02e-044562HP:0003500
HumanPhenoPointed chin

BICRA SPTBN1 NSD1 CASZ1 MED12L ELN VPS37D

7.04e-04138567HP:0000307
HumanPhenoPatent ductus arteriosus

GATA4 NSD1 CASZ1 FOCAD PIGT PTPN11 KMT2D KMT2A ELN DNAH9 CUX1 VPS37D

7.19e-043825612HP:0001643
HumanPhenoMedial flaring of the eyebrow

DYM WARS1 BICRA SPTBN1 BBS9 KMT2A ELN TAF4 KNL1

7.40e-04228569HP:0010747
HumanPhenoAbnormal lip morphology

FLNB DPYD MAGEL2 DYM WARS1 DYNC2H1 NEXMIF SPTBN1 GATA4 NSD1 PTPN22 RFX7 BBS9 CASZ1 GREB1L PIGT PTPN11 KMT2D MED12L KMT2A ELN TAF4 CUX1 VPS37D KNL1

7.42e-0412495625HP:0000159
HumanPhenoAbnormal forearm bone morphology

FLNB MAGEL2 DYNC2H1 BICRA PIGT PTPN11 ELN VPS37D

7.44e-04182568HP:0040073
HumanPhenoAnteverted nares

CEP104 FLNB DPYD BICRA NEXMIF SPTBN1 NSD1 RFX7 PIGT KMT2D MED12L KMT2A ELN TAF4 FH

7.45e-045595615HP:0000463
HumanPhenoUpturned nose

CEP104 FLNB DPYD BICRA NEXMIF SPTBN1 NSD1 RFX7 PIGT KMT2D MED12L KMT2A ELN TAF4 FH

7.45e-045595615HP:0000427
HumanPhenoUnilateral renal agenesis

WARS1 PTPN11 KMT2D ADGRG2 ELN KNL1

7.62e-04101566HP:0000122
HumanPhenoAbnormal renal morphology

FLNB WARS1 DYNC2H1 BICRA NEXMIF GATA4 NSD1 XDH PTPN22 RFX7 BBS9 CASZ1 GREB1L FOCAD PIGT PTPN11 KMT2D TRNT1 ADGRG2 AGXT KMT2A ELN FH VPS37D KNL1

7.71e-0412525625HP:0012210
HumanPhenoAbnormal eyelid morphology

FLNB DPYD MAGEL2 WARS1 DYNC2H1 BICRA NEXMIF SPTBN1 GATA4 NSD1 PTPN22 RFX7 BBS9 CASZ1 GREB1L FOCAD TGFBI PIGT PTPN11 KMT2D MED12L KMT2A ELN TAF4 CUX1 VPS37D KNL1

7.86e-0414085627HP:0000492
HumanPhenoUreteral obstruction

NSD1 PTPN22 PIGT KMT2D

8.10e-0439564HP:0006000
HumanPhenoMyopia

DPYD MAGEL2 BICRA NSD1 TGFBI PIGT PTPN11 TRNT1 TKFC ZNF644 MED12L ELN VPS37D

8.65e-044475613HP:0000545
HumanPhenoRadial deviation of finger

FLNB MAGEL2 DYM NEXMIF GATA4 BBS9 CASZ1 PTPN11 KMT2D KMT2A ELN TAF4 VPS37D

8.83e-044485613HP:0009466
DomainPost-SET_dom

NSD1 KMT2D KMT2A

2.29e-04161433IPR003616
DomainEMI_domain

EMILIN2 MMRN1 TGFBI

2.29e-04161433IPR011489
DomainPostSET

NSD1 KMT2D KMT2A

2.29e-04161433SM00508
DomainPOST_SET

NSD1 KMT2D KMT2A

2.29e-04161433PS50868
DomainEMI

EMILIN2 MMRN1 TGFBI

2.76e-04171433PS51041
DomainFYrich_C

KMT2D KMT2A

5.73e-0451432IPR003889
DomainFYrich_N

KMT2D KMT2A

5.73e-0451432IPR003888
DomainFYRC

KMT2D KMT2A

5.73e-0451432SM00542
DomainFYRN

KMT2D KMT2A

5.73e-0451432SM00541
DomainFYRN

KMT2D KMT2A

5.73e-0451432PF05964
DomainFYRC

KMT2D KMT2A

5.73e-0451432PF05965
DomainFYRC

KMT2D KMT2A

5.73e-0451432PS51543
DomainFYRN

KMT2D KMT2A

5.73e-0451432PS51542
PathwayREACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS

NUP50 NUP62 POM121C TRNT1 NUP153

4.69e-0559955M27606
PathwayREACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

NUP50 NUP62 POM121C NUP153

6.02e-0532954M29579
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

NUP50 NUP62 POM121C NUP153

6.82e-0533954M27016
PathwayREACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN

NUP50 NUP62 POM121C NUP153

7.69e-0534954M27041
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP50 NUP62 POM121C NUP153

8.63e-0535954M27320
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP50 NUP62 POM121C NUP153

9.66e-0536954M26974
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP50 NUP62 POM121C NUP153

9.66e-0536954M27245
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

NUP50 NUP62 POM121C NUP153

1.08e-0437954M1029
PathwayREACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS

NUP50 NUP62 POM121C NUP153

1.08e-0437954M27038
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP50 NUP62 POM121C NUP153

1.33e-0439954M27238
PathwayREACTOME_ISG15_ANTIVIRAL_MECHANISM

NUP50 FLNB NUP62 POM121C NUP153

1.39e-0474955M48006
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP50 NUP62 POM121C NUP153

1.47e-0440954MM14945
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

NUP50 NUP62 POM121C NUP153

1.62e-0441954M29574
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP50 NUP62 POM121C NUP153

1.62e-0441954MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP50 NUP62 POM121C NUP153

1.78e-0442954MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP50 NUP62 POM121C NUP153

1.95e-0443954MM14609
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP50 NUP62 POM121C NUP153

1.95e-0443954M26975
PathwayREACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES

NUP50 NUP62 POM121C PTPN11 TKFC NUP153

2.05e-04126956M45009
PathwayREACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS

NUP50 NUP62 POM121C NUP153

2.14e-0444954M109
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP50 NUP62 POM121C NUP153

2.54e-0446954M27397
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP50 NUP62 POM121C NUP153

2.77e-0447954M27395
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP50 NUP62 POM121C NUP153

2.77e-0447954MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

NUP50 NUP62 POM121C NUP153

3.25e-0449954MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP50 NUP62 POM121C NUP153

3.52e-0450954MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP50 NUP62 POM121C NUP153

3.80e-0451954MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP50 NUP62 POM121C NUP153

4.40e-0453954M27212
PathwayREACTOME_SNRNP_ASSEMBLY

NUP50 NUP62 POM121C NUP153

4.73e-0454954M29594
PathwayREACTOME_HIV_LIFE_CYCLE

NUP50 NUP62 POM121C TAF4 VPS37D NUP153

5.06e-04149956M4076
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP50 NUP62 POM121C NUP153

5.07e-0455954MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP50 NUP62 POM121C NUP153

6.22e-0458954MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

NUP50 NUP62 POM121C NUP153

6.22e-0458954MM14736
PathwayWP_7Q1123_COPY_NUMBER_VARIATION_SYNDROME

ATP5PB CLASP2 NUP62 ELN VPS37D

7.41e-04106955M40052
PathwayREACTOME_TRNA_PROCESSING

NUP50 NUP62 POM121C TRNT1 NUP153

9.12e-04111955M27684
PathwayREACTOME_HIV_INFECTION

NUP50 PSMD9 NUP62 POM121C TAF4 VPS37D NUP153

9.43e-04231957M12469
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP50 NUP62 POM121C NUP153

9.57e-0465954MM15147
PathwayREACTOME_MITOTIC_PROPHASE

NUP50 NUP62 POM121C GOLGA8B NUP153

1.03e-03114955MM15361
PathwayREACTOME_MEMBRANE_TRAFFICKING

AMPH GBF1 BLOC1S4 SPTBN1 PIP5K1C SEC31B PICALM GGA3 SEC23IP CUX1 VPS37D KIF22

1.05e-036309512M11480
PathwayREACTOME_HCMV_LATE_EVENTS

NUP50 NUP62 POM121C VPS37D NUP153

1.11e-03116955M29806
PathwayREACTOME_M_PHASE

NUP50 CLASP2 PSMD9 NUP62 POM121C CLIP1 GOLGA8B ANAPC16 NUP153

1.18e-03387959MM15364
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP50 NUP62 POM121C NUP153

1.33e-0371954M27394
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP50 NUP62 POM121C NUP153

1.48e-0373954MM14948
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ABCA2 GBF1 EP400 BICRA NSD1 C15orf39 CLASP2 BCL9 MBD6 ANKHD1 PIP5K1C POM121C LYST REXO1 CASZ1 GGA3 PPP1R26 FOCAD MST1R TNRC18 KMT2D TKFC UBN1 NAV1 NLRC5 ULK2

1.86e-1211051502635748872
Pubmed

Interaction network of human early embryonic transcription factors.

EP400 BICRA GATA4 C15orf39 PROSER1 BCL9 RFX7 MBD6 POM121C TNRC18 KMT2D ZNF644 KMT2A TAF4

4.57e-103511501438297188
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

MAGEL2 GBF1 EP400 PDLIM7 BICRA PTPN22 BCL9 PIP5K1C POM121C PICALM GGA3 TNRC18 UBN1 NEURL4 NUP153

6.73e-104301501535044719
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

PRR36 MAP6 SPTBN1 NSD1 CLASP2 BCL9 CLIP1 TMEM132B PICALM NOSIP CACNG2 GPR158 SEC23IP NAV1 GOLGA8B TAF4 CAMSAP2 NEURL4 CUX1 NUP153 BEGAIN

1.21e-099631502128671696
Pubmed

Human transcription factor protein interaction networks.

ATP5PB EP400 BICRA SPTBN1 GATA4 C15orf39 PROSER1 NUP62 BCL9 RFX7 MBD6 ANKHD1 POM121C NOSIP ZNF771 KMT2D UBN1 DCP1B ZNF644 KMT2A RPRD2 TAF4 CUX1

5.41e-0814291502335140242
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

TICRR EP400 POM121C ZNF644 TAF4 CUX1 KNL1

7.59e-07116150730804394
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NUP50 SPR SUN1 NUP62 BCL9 ANKHD1 POM121C KMT2D TKFC DCP1B SEC23IP NUP153

7.72e-074571501232344865
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

ATP5PB GBF1 DYNC2H1 BICRA CLASP2 CLIP1 FOCAD TGFBI PIGT PTPN11 TKFC SEC23IP TVP23C TAF4 FH CAMSAP2 PCDH9 CUX1

8.21e-0710611501833845483
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

EP400 PDLIM7 NSD1 ANKHD1 GGA3 PTPN11 KMT2D SEC23IP KMT2A RPRD2 TAF4 AMOTL2 CUX1

8.39e-075491501338280479
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NUP50 WARS1 EP400 SPR BICRA C15orf39 PTPN22 BCL9 NOSIP TNRC18 KMT2D ZNF644 KMT2A TAF4 FKBP5 CUX1 NUP153 KNL1

1.42e-0611031501834189442
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

EP400 GATA4 NSD1 BCL9 KMT2D CUX1

1.67e-0683150628794006
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

EP400 BCL9 CASZ1 TNRC18 KMT2D KMT2A RPRD2 CUX1 KNL1

2.70e-06268150933640491
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NUP50 WARS1 EP400 NUP62 ANKHD1 POM121C PICALM GGA3 PTPN11 SEC23IP KMT2A RPRD2 CAMSAP2 NUP153 PARP12 KNL1

3.08e-069341501633916271
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

DYNC2H1 MUC16 BCL9 POM121C SEC31B CASZ1 NOSIP PIGT KMT2D SEC23IP CUX1 KNL1 FAM149A

4.35e-066381501331182584
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

GBF1 RFX7 ANKHD1 KMT2D ANAPC16 CAMSAP2

6.96e-06106150631024071
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

GBF1 EP400 SPTBN1 BCL9 RFX7 CLIP1 REXO1 KMT2D PTPRC UBN1 ZNF644 KMT2A FKBP5 NUP153

7.17e-067741501415302935
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

EP400 MAP6 TMEM132B FOCAD TNRC18 NEURL4

7.35e-06107150611347906
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

NUP50 GBF1 WARS1 ZNF644 NAV1 CDC25A NUP153 KNL1

8.10e-06232150825515538
Pubmed

Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.

NUP62 FKBP5 NUP153

9.23e-0610150319581287
Pubmed

Proteomic profiling of Myc-associated proteins.

EP400 PDLIM7 XDH SEC31B KNDC1 PDZD2

1.06e-05114150621150319
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

EP400 AHCYL2 PIP5K1C GGA3 FOCAD ZNF644 NAV1 CAMSAP2 ULK2 PDZD2

1.18e-054071501012693553
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NUP50 TICRR EP400 NSD1 NUP62 RFX7 POM121C CASZ1 KMT2D UBN1 ZNF644 KMT2A RPRD2 ANAPC16 TAF4 CUX1 NUP153 KIF22

1.28e-0512941501830804502
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

NUP50 C15orf39 BCL9 RFX7 POM121C RPRD2 NUP153

1.40e-05180150735198878
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

FLNB C15orf39 ANKHD1 GREB1L KMT2D ZNF644 SEC23IP NAV1 CUX1 KNL1

1.48e-054181501034709266
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

TGM3 KMT2D UBN1 SEC23IP NAV1 RPRD2 CAMSAP2

1.61e-05184150732908313
Pubmed

Tagging genes with cassette-exchange sites.

FLNB SUN1 CLASP2 RFX7 REXO1 GGA3 PTPN11 TAF4 KIF22

1.62e-05335150915741177
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

NUP50 NUP62 POM121C DNAH9 NUP153 PDZD2

1.63e-05123150626912792
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

NUP50 EP400 BICRA NSD1 NUP62 PICALM NOSIP UBN1 ZNF644 KMT2A RPRD2 TAF4 CUX1 NUP153 KNL1

1.75e-059541501536373674
Pubmed

BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins.

NUP62 NUP153

1.85e-052150225410863
Pubmed

A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.

PICALM KMT2A

1.85e-052150212461747
Pubmed

A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells.

MST1R CDC25A

1.85e-052150212411323
Pubmed

Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.

GP6 PTPRC

1.85e-052150231226719
Pubmed

TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

TRAF1 PTPRC

1.85e-052150225834819
Pubmed

Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).

KMT2A KNL1

1.85e-052150212618768
Pubmed

Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.

KMT2D KMT2A

1.85e-052150226711341
Pubmed

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.

KMT2D KMT2A

1.85e-052150224423662
Pubmed

Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus.

NUP62 NUP153

1.85e-052150212163599
Pubmed

PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion.

PTPN22 PTPRC

1.85e-052150232047502
Pubmed

Nuclear import of cutaneous beta genus HPV8 E7 oncoprotein is mediated by hydrophobic interactions between its zinc-binding domain and FG nucleoporins.

NUP62 NUP153

1.85e-052150224418548
Pubmed

βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin.

SPTBN1 SERPINA4

1.85e-052150225307947
Pubmed

The Nup153-Nup50 protein interface and its role in nuclear import.

NUP50 NUP153

1.85e-052150223007389
Pubmed

Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets.

GP6 ITGA2

1.85e-052150231398205
Pubmed

Dependence of cell survival on correlative activities of xanthine oxidase and dihydopyrimidine dehydrogenase in human brain-derived cell culture.

DPYD XDH

1.85e-052150223597150
Pubmed

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

EP400 KMT2D KMT2A

2.18e-0513150316510874
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

NUP50 NUP62 POM121C NUP153

2.19e-0538150412791264
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

FLNB DYM BICRA CLASP2 AHCYL2 CASZ1 TNRC18 TRNT1 GPR158 KNDC1 TVP23C NAV1 NLRC5 RPRD2 TAF4 FKBP5 CUX1 PDZD2 FAM149A

2.39e-0514891501928611215
Pubmed

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.

NUP50 NUP62 KMT2A NUP153

2.69e-0540150437516964
Pubmed

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

EP400 KMT2D KMT2A

3.44e-0515150316510875
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

NUP62 POM121C NUP153

3.44e-0515150314697343
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ATP5PB FLNB AMPH WARS1 MAP6 SPTBN1 SUN1 AHCYL2 CACNG2 TNRC18 GPR158 AKR7A3 KNDC1 NAV1 CAMSAP2 BEGAIN

3.56e-0511391501636417873
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

NUP50 GBF1 GATA4 NUP62 PICALM PPP1R26 TNRC18 PTPN11 UBN1 RPRD2 TAF4 KIF22

4.77e-056891501236543142
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

NUP50 PDLIM7 SPTBN1 SUN1 PTPN22 CLASP2 PTPN11 KMT2D PTPRC CDC25A NEURL4 FKBP5 NUP153 KNL1 KIF22

5.17e-0510491501527880917
Pubmed

Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.

GP6 ITGA2

5.53e-053150219622836
Pubmed

Interactions and three-dimensional localization of a group of nuclear pore complex proteins.

NUP62 NUP153

5.53e-05315028045926
Pubmed

CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.

CLASP2 CLIP1

5.53e-053150225589673
Pubmed

Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes.

GP6 ITGA2

5.53e-053150215265786
Pubmed

Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke.

GP6 ITGA2

5.53e-053150212871362
Pubmed

Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen.

GP6 ITGA2

5.53e-053150218983487
Pubmed

Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.

KMT2D KMT2A

5.53e-053150226902498
Pubmed

Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.

NUP50 NUP153

5.53e-053150224943837
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2D KMT2A

5.53e-053150223932714
Pubmed

A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.

KMT2A KNL1

5.53e-053150212618766
Pubmed

AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.

AMOTL2 FKBP5

5.53e-053150234165350
Pubmed

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling.

PTPN22 PTPRC

5.53e-053150226077719
Pubmed

Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma.

DYNC2H1 PTPN11

5.53e-053150231197031
Pubmed

Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood.

GP6 ITGA2

5.53e-053150214563646
Pubmed

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

PTPN22 PTPRC

5.53e-053150219299707
Pubmed

Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway.

AMBN ITGA2

5.53e-053150223385480
Pubmed

GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling.

GATA4 ADRA1B

5.53e-053150218552157
Pubmed

Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.

GP6 ITGA2

5.53e-053150223132859
Pubmed

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood.

GP6 ITGA2

5.53e-053150220351310
Pubmed

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.

GP6 ITGA2

5.53e-053150225415203
Pubmed

SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.

CLASP2 CLIP1

5.53e-053150233372035
Pubmed

Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin.

GP6 ITGA2

5.53e-053150216113793
Pubmed

MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.

KMT2D KMT2A

5.53e-053150223192982
Pubmed

CLIPs and CLASPs and cellular dynamics.

CLASP2 CLIP1

5.53e-053150215928712
Pubmed

IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.

AMOTL2 FKBP5

5.53e-053150230794467
Pubmed

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

KMT2D KMT2A

5.53e-053150230315824
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

NUP50 DYNC2H1 IFFO1 PDLIM7 C15orf39 CLASP2 PSMD9 POM121C BBS9 CLIP1 PIGT DCP1B SEC23IP NAV1 CAMSAP2 NEURL4 PCDH9

5.95e-0513211501727173435
Pubmed

Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.

KMT2D KMT2A

1.10e-044150222863532
Pubmed

Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.

GP6 PTPN11

1.10e-044150221297004
Pubmed

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.

CLASP2 CLIP1

1.10e-044150222851317
Pubmed

KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.

KMT2D KMT2A

1.10e-044150237722486
Pubmed

Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.

NUP50 NUP153

1.10e-044150228751496
Pubmed

Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis.

TRAF1 PTPN22

1.10e-044150220822712
Pubmed

Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.

NUP62 NUP153

1.10e-044150215522285
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2D KMT2A

1.10e-044150223129768
Pubmed

Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.

GP6 ITGA2

1.10e-044150219192113
Pubmed

Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.

NUP62 NUP153

1.10e-044150230022050
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2D KMT2A

1.10e-044150224081332
Pubmed

Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins.

NUP62 NUP153

1.10e-044150224739174
Pubmed

Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration.

CLIP1 NAV1

1.10e-044150215797708
Pubmed

βig-h3 promotes human osteosarcoma cells metastasis by interacting with integrin α2β1 and activating PI3K signaling pathway.

ITGA2 TGFBI

1.10e-044150224595049
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

EP400 TNRC18 KMT2D

1.31e-042315039225980
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ATP5PB NUP50 FLNB TRAF1 GBF1 WARS1 DYNC2H1 SPTBN1 CLASP2 NUP62 ANKHD1 TGM3 PTPN11 SEC23IP FH NUP153 MGAM2

1.48e-0414251501730948266
Pubmed

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

NUP50 NUP62 NUP153

1.69e-0425150310601273
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

BLOC1S4 PDLIM7 C15orf39 CLASP2 AHCYL2 PICALM DCP1B SEC23IP KNDC1 RPRD2 AMOTL2 CAMSAP2 PARP12 BEGAIN

1.70e-0410381501426673895
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

CASS4 AMPH SPTBN1 NAV1 CCSER1

1.79e-04120150531413325
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

NUP50 SPTBN1 NAV1 RPRD2 CAMSAP2 NUP153 KNL1 KIF22

1.83e-04361150830344098
Pubmed

DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.

FEZF2 CUX1

1.83e-045150223175819
InteractionFEV interactions

EP400 BICRA GATA4 C15orf39 BCL9 KMT2D ZNF644 KMT2A TAF4 CUX1

2.32e-0620314610int:FEV
InteractionEGR2 interactions

EP400 BICRA C15orf39 PROSER1 BCL9 TNRC18 KMT2D ZNF644 KMT2A

4.41e-061711469int:EGR2
InteractionASF1A interactions

EP400 BICRA NSD1 CASZ1 KMT2D UBN1 ZNF644 KMT2A CUX1 KIF22

1.41e-0524914610int:ASF1A
InteractionCRX interactions

EP400 BICRA GATA4 C15orf39 PROSER1 BCL9 PICALM TNRC18 KMT2D ZNF644

1.67e-0525414610int:CRX
InteractionTOP3B interactions

ABCA2 GBF1 EP400 BICRA NSD1 C15orf39 CLASP2 BCL9 MBD6 ANKHD1 PIP5K1C POM121C LYST REXO1 CASZ1 GGA3 PPP1R26 FOCAD MST1R TNRC18 KMT2D TKFC UBN1 NAV1 NLRC5 ULK2

1.88e-05147014626int:TOP3B
InteractionPHF21A interactions

FLNB TRAF1 C15orf39 PSMD9 NUP62 ANKHD1 KMT2D SEC23IP NAV1 KNL1 KIF22

4.19e-0534314611int:PHF21A
InteractionDYRK1A interactions

AMPH ABCA2 GBF1 PDLIM7 SPTBN1 RFX7 ANKHD1 PICALM GGA3 KMT2D KNDC1 ANAPC16 CAMSAP2 NUP153

4.99e-0555214614int:DYRK1A
InteractionNUP35 interactions

NUP50 SPR NUP62 BCL9 ANKHD1 POM121C KMT2D TKFC DCP1B SEC23IP NUP153 PDZD2

6.26e-0542414612int:NUP35
GeneFamilyAtaxins|Trinucleotide repeat containing

EP400 TNRC18 KMT2D

2.22e-0425863775
GeneFamilyEMI domain containing

EMILIN2 MMRN1

4.62e-047862540
GeneFamilyNucleoporins

NUP50 NUP62 NUP153

4.66e-04328631051
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD1 KMT2D KMT2A

5.59e-0434863487
GeneFamilyPHD finger proteins

TCF19 NSD1 KMT2D KMT2A

8.93e-049086488
GeneFamilyProtein tyrosine phosphatases, non-receptor type

PTPN22 PTPN11

3.26e-0318862812
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

TRAF1 IFFO1 BICRA SUN1 GSDMB C15orf39 GAL3ST4 NUP62 MBD6 ZNF467 REXO1 CASZ1 GGA3 PIGT FCGRT SMPDL3A NLRC5 GOLGA8B CUX1 KIF22

1.77e-0790514720M40865
CoexpressionGSE27786_LIN_NEG_VS_CD8_TCELL_DN

LYST CACNG2 TNRC18 PTPRC FCGRT NLRC5 RPRD2 ANAPC16

1.80e-052001478M4777
CoexpressionGSE17580_TREG_VS_TEFF_DN

NUP50 DYM SPTBN1 BBS9 LYST HOXD12 FCGRT NUP153

1.80e-052001478M3671
CoexpressionLAKE_ADULT_KIDNEY_C30_IMMUNE_CELLS_MACROPHAGES

DPYD PTPRC FKBP5

2.01e-05101473M39249
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

WARS1 TOX MAP6 LYST PTPN11 SMPDL3A FKBP5

2.29e-06176150756c055488e34605d32562571a2fee621b47c9441
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AMPH TMEM132B FOCAD KIAA1549L GPR158 GOLGA8B CCSER1

4.65e-061961507676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AMPH TMEM132B FOCAD KIAA1549L GPR158 GOLGA8B CCSER1

4.97e-0619815076d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AMPH TMEM132B FOCAD KIAA1549L GPR158 GOLGA8B CCSER1

4.97e-0619815074ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellHealthy_donor-Classical_Monocyte|World / disease group, cell group and cell class (v2)

DPYD WARS1 EMILIN2 C15orf39 ZNF467 TGFBI FCGRT

5.14e-06199150745e9099a13becb1e235435ceaaffb92b82ce34ee
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

FLNB TRAF1 FAM184A SPTBN1 SEC31B LYST NOSIP

5.14e-061991507f307d4887b28cf60a591439e278fd668409cb104
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPR ITGA2 ZNF467 TMEM132B PODN CCSER1

6.55e-06135150652b5c664c0b7a303c6084d508748dcb6c38a0c23
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDLIM7 C15orf39 SOCS6 ZNF467 TGM3 CUX1

1.24e-0515115067b50425d2bbd7b6ff2a6e67d3e2470a4455740e0
ToppCellASK452-Epithelial-Type_2|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

FAM184A TOX SPR HELB TGM3 AMOTL2

1.50e-051561506e2b8d65c38cedb8ec6c3c1b138957145af931c51
ToppCellICU-SEP-Lymphocyte-T_NK-dnT|ICU-SEP / Disease, Lineage and Cell Type

TRAF1 SPTBN1 GSDMB ZNF771 CAMSAP2 KNL1

2.12e-05166150696d92316cee20b722fe782db9dafcceb8f2c220b
ToppCelldroplet-Marrow-nan-3m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMILIN2 ZNF467 LYST TGFBI SMPDL3A NAV1

2.51e-051711506992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TCF19 DYNC2H1 PPP1R26 TAF4 KNL1 KIF22

2.59e-0517215067c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TICRR TCF19 CDC25A KNL1 KIF22 CCSER1

2.86e-051751506a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRAF1 TOX PDLIM7 PTPN22 ANAPC16 THNSL2

2.86e-05175150641174b7381932a2cc94063c7202eeff6d3208cc7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TOX ITGA2 CASZ1 GREB1L INPP5J CCSER1

3.45e-051811506aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellControl-Myeloid-DC1|Control / Condition, Lineage and Cell class

CASS4 FLNB TOX NAV1 FAM149A CCSER1

3.45e-0518115065a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOX SPTBN1 NSD1 ITGA2 CLIP1 LYST

3.56e-051821506e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOX SPTBN1 NSD1 ITGA2 CLIP1 LYST

3.56e-0518215061710eab3037a87609d21838be2d2d29c3bc36651
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-DC1|lymph-node_spleen / Manually curated celltypes from each tissue

WARS1 ZNF467 TGFBI FCGRT NAV1 CCSER1

3.67e-051831506c9e3d91f4c3395a73295b92e25608e0effb5d241
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 NSD1 CLIP1 LYST PTPRC KMT2A

3.79e-0518415061154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellDendritic_Cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

CASS4 TCF19 TGFBI PTPRC AGXT FKBP5

4.02e-0518615061d52912bd17e232cf39b2423a4d93585c164ba34
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

DYM PROSER1 CLASP2 SOCS6 TRNT1 PARP12

4.27e-0518815068f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GP6 TRAF1 TOX PTPN22 LYST PTPRC

4.27e-0518815066686dbba990066568aa7573e70a7db8b4758f457
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRR36 ERVMER34-1 KNDC1 THNSL2 AMOTL2 PDZD2

4.53e-05190150681f8f2cddf4c51b879f315260cd1fca80355a371
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic-stroma-muscle|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRR36 ERVMER34-1 KNDC1 THNSL2 AMOTL2 PDZD2

4.53e-05190150620106e5213f6a7560554b8b4f84b23c5554ba975
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRR36 ERVMER34-1 KNDC1 THNSL2 AMOTL2 PDZD2

4.53e-051901506877b544decf302e0d41be23dffa1861f79c70914
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRAF1 TOX PTPN22 HELB PTPRC NLRC5

4.66e-051911506c7be771543089fc94e5c62fd22f745189642aec3
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TRAF1 FAM184A CLASP2 HELB PTPRC KMT2A

4.80e-05192150647646d7e4990be85072987f92bf18d52f8da752e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP47 FAM184A DYNC2H1 ITGA2 ELN DNAH9

4.94e-051931506ea345d34440b25f65358a53dc72831998d1c3620
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRAF1 TOX PTPN22 HELB PTPRC NLRC5

4.94e-051931506b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TOX PTPN22 HELB PTPRC NLRC5 FKBP5

5.08e-0519415063d6f2d190dd50804afea299957cc44c2bb756134
ToppCellhealthy_donor-Myeloid-Monocytic-CD16+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

WARS1 EMILIN2 LYST TGFBI KNDC1 CUX1

5.08e-051941506ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TOX NEXMIF SPTBN1 ITGA2 GREB1L CCSER1

5.08e-0519415064579b4a44f7c731553a284843c296866027d7c0e
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ATP5PB DPYD EMILIN2 LYST PICALM TGFBI

5.08e-051941506885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCellImmune-T_lymphocyte|World / Lineage, Cell type, age group and donor

TRAF1 TOX PTPN22 HELB PTPRC NLRC5

5.08e-051941506f47fa18c87b35a3960557f8169ff7830dd6ecb80
ToppCellHealthy-Classical_Monocyte|World / disease group, cell group and cell class

DPYD EMILIN2 ZNF467 LYST TGFBI FCGRT

5.23e-0519515060d96f456cc84ebb2543406fb2374c6d7cedd3c4d
ToppCellChildren_(3_yrs)-Immune-monocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYD AMPH EMILIN2 PTPRC NAV1 FKBP5

5.23e-05195150681a28289eda1a8a1a31b7357106f64ac5000e172
ToppCell10x5'-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages|GI_small-bowel / Manually curated celltypes from each tissue

EMILIN2 GAL3ST4 TGFBI FCGRT SMPDL3A NAV1

5.38e-051961506075e5746fa5cb121115a1d51b823c0fbf8d54305
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPYD WARS1 EMILIN2 LYST TGFBI FCGRT

5.53e-0519715062afc23f7394d9b40bdf06527c5e6b553e1b02dca
ToppCellCOVID-19_Severe-Myeloid-Non-classical_Monocyte|COVID-19_Severe / Disease group, lineage and cell class

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.53e-051971506c5837b9a5a39a0f607a4e217ade9fc87d82a5406
ToppCellMonocytes-cDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

SOCS6 ZNF467 TGFBI FCGRT NAV1 CCSER1

5.53e-0519715063388c104af4c6a05988e102627e0c5e34d9dcc45
ToppCellCOVID-19_Severe-Non-classical_Monocyte|World / disease group, cell group and cell class

WARS1 EMILIN2 C15orf39 LYST SMPDL3A CUX1

5.53e-05197150660fee75b12451206bb2c07b61651a73c59ec6ade
ToppCellmild_COVID-19-Classical_Monocyte|World / disease group, cell group and cell class (v2)

WARS1 EMILIN2 C15orf39 ZNF467 TGFBI FCGRT

5.53e-0519715065d826f4d7b7a46847c67e6bef38eb860bc808a6c
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.69e-0519815069b8679b3dd8f4220d71f607b7080cb88d6e71129
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.69e-0519815068b6b602ebe59b6dca6a22f17385d3160ff3ac67e
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AMPH TMEM132B FOCAD KIAA1549L GOLGA8B CCSER1

5.69e-051981506c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.69e-051981506b9030390316baf456135f85f831394e1e11ecf3e
ToppCellsevere-dn_T|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FLNB TRAF1 FAM184A SPTBN1 LYST NOSIP

5.69e-051981506d4f2213af45ada47e6c62675f468ce05692db507
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TOX ZNF467 TGFBI NLRC5 MGAM2 CCSER1

5.69e-05198150633690e16e4549b110e5b67f84b9515c696fe05e1
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.69e-051981506d36a3cda7e5f385d2391e9b0dfb027d3c4549320
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.69e-0519815065436c3ed16e10e00c686f1ab0b0a68728a1a9985
ToppCellmild_COVID-19-Classical_Monocyte|mild_COVID-19 / disease group, cell group and cell class (v2)

WARS1 EMILIN2 C15orf39 ZNF467 TGFBI FCGRT

5.69e-0519815065b31b6e008e05d6528656114fbe0ccae8ffe13b1
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.69e-0519815064f67067d8142ca11b2d80195dac8d62a8d24d52c
ToppCellmild-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPYD EMILIN2 ZNF467 PICALM TGFBI FCGRT

5.85e-051991506d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell356C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FLNB SPTBN1 PIGT NAV1 PODN ELN

5.85e-051991506beca4c7eb29ac771fd37f30cd23d4dce4afcfff8
ToppCell356C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FLNB SPTBN1 PIGT NAV1 PODN ELN

5.85e-051991506cd3ab9a75b40e0d417d53b3d8756fc9bed30ac83
ToppCellHealthy/Control-Classical_Monocyte|World / Disease group and Cell class

WARS1 EMILIN2 C15orf39 ZNF467 TGFBI FCGRT

5.85e-051991506527c767a09f911e319f7ad230b6518cebc0f367d
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DPYD WARS1 EMILIN2 ZNF467 TGFBI FCGRT

5.85e-05199150696dfbcf5261286f17d9718b04ebb7b288d229b52
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

DPYD DYM CLASP2 RFX7 FOCAD CCSER1

5.85e-05199150694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellHealthy_donor-Classical_Monocyte|Healthy_donor / disease group, cell group and cell class (v2)

WARS1 EMILIN2 C15orf39 ZNF467 TGFBI FCGRT

5.85e-051991506af3a80dbf5e0306b80f420fd41f1aaed81fe9c46
ToppCellHealthy/Control-Classical_Monocyte|Healthy/Control / Disease group and Cell class

WARS1 EMILIN2 C15orf39 ZNF467 TGFBI FCGRT

5.85e-0519915064e8c7445d32fd2b7a50524dcd52141e76850c3df
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

5.85e-051991506fa5ad81554969fffe5e779614d071d9194a7182c
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DPYD WARS1 EMILIN2 ZNF467 TGFBI FCGRT

5.85e-05199150687d513a521dd0359f4f79b01e9e97eacb0a3c6e2
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD ABCA2 ITGA2 GREB1L FAM124A PCDH9

6.02e-0520015064dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CASS4 TRGV8 PTPN22 PTPRC NLRC5 FKBP5

6.02e-0520015065f41906cf1585e09b150a84364d47c3e466dc5b7
ToppCellParenchymal-10x5prime-Immune_Myeloid-Monocytic-Monocyte_CD16|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

WARS1 EMILIN2 C15orf39 LYST PTPRC CUX1

6.02e-05200150683d9aa5b46ae7a71a258b2e44b3251f95bc9a1b7
ToppCellCOVID-19-COVID-19_Severe-Myeloid-CD16+_Monocyte|COVID-19_Severe / Disease, condition lineage and cell class

WARS1 EMILIN2 C15orf39 FCGRT SMPDL3A KNDC1

6.02e-05200150658fbb7fc7159cbc417e6b457d60b7beba9b90da6
ToppCellmild-Non-classical_Monocyte|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

WARS1 C15orf39 LYST FCGRT SMPDL3A CUX1

6.02e-052001506692b48da9fd56bafcb3c8b33b0fe369160881c45
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-dn_T|COVID-19_Severe / Disease, condition lineage and cell class

FLNB TRAF1 FAM184A SPTBN1 LYST NOSIP

6.02e-052001506d01aa5fccada22f97d8350ad5888df2aadb5bb1c
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD ABCA2 ITGA2 GREB1L FAM124A PCDH9

6.02e-05200150626b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellmild-Non-classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

WARS1 EMILIN2 C15orf39 LYST ULK2 CUX1

6.02e-052001506334bab6bf93d455f3526e817ea5785d8b6ee531c
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF1 PTPN22 HELB PTPRC NLRC5 FKBP5

6.02e-052001506c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCellmild-Classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPYD WARS1 EMILIN2 PICALM TGFBI FCGRT

6.02e-052001506c8b80d4e7f70c66cbbdd0665821bcd5db69c7d35
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD ABCA2 ITGA2 GREB1L FAM124A PCDH9

6.02e-0520015061314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF1 PTPN22 HELB PTPRC NLRC5 FKBP5

6.02e-0520015069de4d6ebb7e9bee5d811519eb05913ef30f70786
ToppCellcontrol-Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EMILIN2 C15orf39 ZNF467 PICALM TGFBI TNRC18

6.02e-052001506b5d197472799cc61d7497faed91ac2564ae4930a
ToppCellmild-HLA-DR+_CD83+_Monocyte|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPYD WARS1 EMILIN2 LYST TGFBI FCGRT

6.02e-0520015068a480f487b52938d00b53bf4b18f067353d34419
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD ABCA2 ITGA2 GREB1L FAM124A PCDH9

6.02e-0520015068b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellsevere-Non-classical_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

WARS1 EMILIN2 C15orf39 TGFBI FCGRT SMPDL3A

6.02e-0520015066cc7190a4ffc6c06335072f3b5b5f98eae36e2ce
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF1 PTPN22 HELB PTPRC NLRC5 FKBP5

6.02e-052001506f7a9d8b99de19e9842422bada348d940e0863645
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD ABCA2 ITGA2 GREB1L FAM124A PCDH9

6.02e-052001506272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPYD EMILIN2 ZNF467 LYST TGFBI TNRC18

6.02e-0520015069e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

DPYD ABCA2 ITGA2 GREB1L FAM124A PCDH9

6.02e-0520015065f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCellCOVID_non-vent-Myeloid-Monocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

DPYD WARS1 EMILIN2 LYST TGFBI FCGRT

6.02e-0520015064243a9d32f3a11141284d0d944cb81194b532876
ToppCell(51)_cDC1|World / shred on Cell_type and subtype

ZNF467 TGFBI FCGRT NAV1 MGAM2 CCSER1

6.71e-052041506a8cf4180c406674b7541917d1fc6127686ba5f8a
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8|GI_small-bowel / Manually curated celltypes from each tissue

FAM184A EMILIN2 RFX7 ZNF467 CAMSAP2

1.16e-041411505b2857b73fd754b879b922c7720b5ac3024976822
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 MINDY4B ITGA2 CASZ1 MED12L

1.20e-0414215055b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

C2CD4B TCF19 MUC16 TGM3 MGAM2

1.41e-041471505c8e5bdc3538089acd35a4b41390afaec0ac6d1aa
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 EMILIN2 XDH TGFBI TGM3

1.70e-0415315050ef7c45cdd854c79e527006034029767f8e108b2
ToppCelldroplet-Fat-SCAT-30m-Myeloid-monocyte|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184A ITGA2 TKFC PTPRC KNL1

1.70e-0415315052731c3d4ac40ecc22108f8f3f45a069077159125
ToppCellRV-17._Lymphocyte|World / Chamber and Cluster_Paper

CASS4 TRAF1 TOX PTPN22 PTPRC

1.80e-041551505189276a3b400b2202e6681e23732e6452bfe704e
ToppCellPND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND07-28-samps / Age Group, Lineage, Cell class and subclass

EMILIN2 PTPN22 LYST PTPRC SMPDL3A

1.86e-041561505166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF1 EMILIN2 XDH MST1R TGM3

1.86e-0415615052ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCellPND07-28-samps-Myeloid-Granulocyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

EMILIN2 PTPN22 LYST PTPRC SMPDL3A

1.86e-0415615055e1c5a7c9293b886920739cf766521df7f69726c
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

TRAF1 FAM184A GSDMB HELB PTPRC

1.86e-0415615051545169694f686d28648a68b552c2ae606599d66
ToppCellfacs-Lung-EPCAM-24m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1A EMILIN2 TGFBI PTPRC GPR158

1.91e-041571505d2cb261a9ee2c90e2e0fc656bd6413fbccb465fc
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1A EMILIN2 TGFBI PTPRC GPR158

1.91e-041571505350069e4d2dbddc82e813e2a2cc43032daa23605
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TCF19 TOX FEZF2 GPR158 OSBP2

1.97e-041581505c8af8964a140acb2987e3b4906d72c546108d229
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR GAL3ST4 ZNF467 PIP5K1C CDC25A

2.03e-041591505c960df9e4fa980401941866b5081facac4590b4d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF1 TCF19 PTPN22 PTPRC NLRC5

2.09e-04160150597c899df1b57fd2bd1867e02bfedf1920c00ad17
Drugcopper fluoride

TPO SPTBN1 ITGA2 CUX1

3.52e-06171454CID000082236
DrugPrednisolone [50-24-8]; Down 200; 11uM; MCF7; HT_HG-U133A

GBF1 NSD1 GSDMB C15orf39 ZNF467 FOCAD TGFBI FH PCDH9

5.19e-0619814595526_DN
Diseaselymphocyte count

FLNB TRAF1 GBF1 PCDHGB2 NSD1 GSDMB PTPN22 RFX7 LYST CASZ1 FOCAD MST1R PTPRC ZNF644 MED12L NLRC5 NEURL4 FKBP5 PARP12 KNL1

3.04e-05146414420EFO_0004587
DiseaseDisproportionate short stature

FLNB DYM DYNC2H1 PTPN11 KIF22

3.85e-05771445C0878659
DiseaseMalignant neoplasm of breast

FLNB DPYD WARS1 DYNC2H1 PDLIM7 GSDMB XDH CLIP1 GGA3 KMT2D PTPRC ZNF644 NLRC5 DNAH9 CUX1 NLRP8

7.45e-05107414416C0006142
DiseaseWeaver syndrome

NSD1 KMT2A

2.34e-0451442C0265210
Diseaseclubfoot (is_implicated_in)

FLNB HOXD12

2.34e-0451442DOID:11836 (is_implicated_in)
Diseasebitter non-alcoholic beverage consumption measurement

AMPH RPRD2 VPS37D

5.09e-04321443EFO_0010093
Diseasephotoreceptor cell layer thickness measurement

CEP104 GBF1 SUN1 CASZ1 FKBP5

8.16e-041481445EFO_0803370
Disease2R,3R-dihydroxybutyrate measurement

WARS1 AGXT

8.33e-0491442EFO_0800314
Diseasesystemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus

FLNB PTPN22 PTPN11

8.47e-04381443EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Diseasetheophylline measurement

ITGA2 CCSER1

1.04e-03101442EFO_0021180
Diseaseglucagon-like peptide-1 measurement

AMBN BICRA

1.04e-03101442EFO_0008465
Diseaseaortic stenosis, aortic valve calcification

FLNB COX7A2P2 NAV1

1.14e-03421443EFO_0000266, EFO_0005239
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

ELN CDC25A

1.26e-03111442DOID:0110861 (biomarker_via_orthology)
Diseasecampesterol measurement

MMRN1 CCSER1

1.26e-03111442EFO_0020008
DiseaseAgents acting on the renin-angiotensin system use measurement

TICRR GATA4 REXO1 CASZ1 PTPN11 AGXT CDC25A

1.33e-033351447EFO_0009931
DiseaseDiuretic use measurement

TICRR GATA4 CASZ1 PTPN11 CDC25A

1.47e-031691445EFO_0009928
Diseaseinsomnia measurement

TEX15 MMRN1 TGFBI MED12L NAV1 KMT2A PCDH9 CCSER1

1.54e-034431448EFO_0007876
DiseaseLeukemia, Myelocytic, Acute

NSD1 PICALM PTPN11 KMT2A CUX1

1.63e-031731445C0023467
Diseasetetralogy of Fallot (is_implicated_in)

GATA4 PTPN11

1.78e-03131442DOID:6419 (is_implicated_in)
DiseaseDiverticular Bleeding

GPR158 ELN

1.78e-03131442C4505353
DiseaseDiverticular Diseases

GPR158 ELN

1.78e-03131442C4317009
Diseaseserum non-albumin protein measurement

TRAF1 GATA4 GSDMB GREB1L PTPN11 FCGRT RPRD2

2.03e-033611447EFO_0004568
Diseaseprecuneus cortex volume measurement

MMRN1 CCSER1

2.07e-03141442EFO_0010326
Diseaselateral ventricle volume change measurement

SERPINA4 FAM149A

2.38e-03151442EFO_0021502
DiseaseBeta blocking agent use measurement

CASZ1 PTPN11 AGXT CDC25A

2.40e-031141444EFO_0009929
Diseasetemporal arteritis (is_implicated_in)

PTPN22 ELN

2.71e-03161442DOID:13375 (is_implicated_in)
Diseaseresponse to opioid

MUC16 SEC23IP PCDH9

3.33e-03611443EFO_0008541
DiseaseAcute Myeloid Leukemia, M1

NSD1 PICALM PTPN11 KMT2A

3.34e-031251444C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

NSD1 PICALM PTPN11 KMT2A

3.34e-031251444C1879321
Diseaseosteochondrodysplasia (is_implicated_in)

FLNB DYM

3.83e-03191442DOID:2256 (is_implicated_in)
DiseaseThyroid preparation use measurement

TPO PTPN22 PTPN11 CAMSAP2 NEURL4

4.33e-032171445EFO_0009933
Diseasemean platelet volume

GP6 BLOC1S4 PCDHGB2 SPTBN1 GATA4 ITGA2 PICALM PTPRC UBN1 ULK2 CUX1 VPS37D

4.36e-03102014412EFO_0004584
Diseasecytotoxicity measurement, response to metformin

THNSL2 CCSER1

4.67e-03211442EFO_0006952, GO_1901558

Protein segments in the cluster

PeptideGeneStartEntry
APKGFLLLSPTSSNA

nan

56

Q6ZS49
TLLAPLNSVFKDGTP

TGFBI

411

Q15582
SLRPAKSVPSVFAAA

AMOTL2

661

Q9Y2J4
AIATQLPPKVSAAFS

EP400

461

Q96L91
SGFSVSDLAPPRKAL

ANAPC16

21

Q96DE5
TKAIPLFGNSLKPDS

AKR7A3

76

O95154
TKNAVLTYPSPAALG

CASS4

751

Q9NQ75
SLFSKSAPSRPQQAG

BLOC1S4

181

Q9NUP1
SPRFAKATAAVAAPL

BEGAIN

346

Q9BUH8
PGLKPFLQSAAATTN

AMBN

121

Q9NP70
AAAALKPSATFDPGS

CASZ1

881

Q86V15
ASPSLPLASTGKFAL

CUX1

466

P39880
PDKPLLSSLFNAAGV

GSDMB

311

Q8TAX9
PAKLSVVSFAPSSNG

ADGRG2

51

Q8IZP9
LGSLFSTLKPPDAVF

ADRA1B

316

P35368
KFINPFGLASATPAT

DPYD

541

Q12882
EANPAKVLASSLSPF

CCSER1

436

Q9C0I3
ASFPNKGVTSIIPAI

COX7A2P2

76

O60397
SAAKFAPSPATAQLA

FAM184A

16

Q8NB25
ATAAPSLKNAAFLGP

ATP5PB

11

P24539
KAFTIQGAPSDSGPL

AMPH

241

P49418
GNNITSAPPFASAKA

NUP50

91

Q9UKX7
GSNEKAALLPAPFSL

NSD1

246

Q96L73
AGEFSPNVPKSLSSA

PTPN22

631

Q9Y2R2
LNPFTAKALSGTSPD

NOSIP

126

Q9Y314
DASPVGIKGFNTLPS

CACNG2

251

Q9Y698
AGSLPKIPSNATLFF

FKBP5

116

Q13451
LGASKTPASIFGPSA

MUC16

13771

Q8WXI7
AVPANAFDSTPNLKG

PODN

536

Q7Z5L7
PPFLASSLLSAAAKA

MBD6

316

Q96DN6
PAGSFVPTNTKQALS

MED12L

1841

Q86YW9
SAASQASAPILGAPK

MAP6

181

Q96JE9
FQPASLNAFKGPSAA

MAGEL2

796

Q9UJ55
LNAFKGPSAASETPK

MAGEL2

801

Q9UJ55
TAQLKRLPSPSLFGN

MGAM2

106

Q2M2H8
LLAKLFETSTAPPAG

FAM149A

11

A5PLN7
TNSVLGPPFLKALAA

NLRP8

711

Q86W28
SLKRPPTAGAQFKSS

MYO1A

556

Q9UBC5
PASSALSANKIAGPR

GPR158

1191

Q5T848
TLPTNASIKFNPGAE

MMRN1

116

Q13201
KGSPVNSLFVAPAVT

SMPDL3A

306

Q92484
PKDNSTIRALFPSLG

ERVMER34-1

366

Q9H9K5
AAGSSAPKPAFAKVL

C2CD4B

11

A6NLJ0
KSLFCLPTGGPSLAS

FAM124A

361

Q86V42
VATGVFAKPSLSAQP

GP6

106

Q9HCN6
LGPDNTSVPTAKFAL

FCGRT

121

P55899
KSPFTVGVAAPLDLS

FLNB

931

O75369
SIPNPSIISSKLGGF

MINDY4B

81

A8MYZ0
AGVPFASDTILKQAP

PCDHGB2

796

Q9Y5G2
NTSFKLVPLSAIPGS

PCDH9

681

Q9HC56
LIPGLSQKPISSFAD

KIF22

206

Q14807
ANADRPVAKSGASPF

PDZD2

2346

O15018
FGNKIGSSPSPAALS

PGLYRP3

121

Q96LB9
AQLLSFSKLPEPTSG

TPO

71

P07202
SPGFLNEPLSSKSQR

KNL1

1076

Q8NG31
SSLFSTGVAPALAPK

GGA3

481

Q9NZ52
SPPALSAALVAKGTS

KIAA1549L

651

Q6ZVL6
ARPSKSNPGDFTLSV

PTPN11

31

Q06124
AQAFLKLLSSSNPPT

LINC00336

121

Q6ZUF6
STTGFALNLKPLAPA

NUP62

286

P37198
KSPSLAAFLANPRGF

GAL3ST4

181

Q96RP7
NLNAVKSPIFTPSSG

GREB1L

1511

Q9C091
NVGLPEAKIFSGPSS

ITGA2

31

P17301
AGPFTKAASEPLSRA

OSBP2

116

Q969R2
FAPSVSLNKTARPFG

PDLIM7

106

Q9NR12
DTNKSPVSLLSLFPG

BBS9

551

Q3SYG4
SQTGLSPKSPFLLAN

NLRC5

1171

Q86WI3
SALPDPGFQKITLSS

PARP12

491

Q9H0J9
TLFASPPAKSTANGN

POM121C

91

A8CG34
NSASLSSVFAGLPLP

PROSER1

421

Q86XN7
QSGDRKSPAFTAVPL

IFFO1

521

Q0D2I5
PALAAKFPVLAQSSG

DCP1B

471

Q8IZD4
SALKLSPQGYASPVS

GATA4

401

P43694
DKPSFFGLPANIARS

DYNC2H1

3991

Q8NCM8
KAPALQPGKSSAVAA

CEP104

881

O60308
VGSKAAASPELSSPL

DYM

266

Q7RTS9
KVAALTGLPFVTAPN

FH

296

P07954
AAASIKSPPVLGSAA

BCL9

901

O00512
PESSLAPAVAALKAA

HOXD12

121

P35452
NVLKSIPASFGTRAP

ABCA2

1701

Q9BZC7
SIAGPRKFPLAQTES

LYST

2591

Q99698
SIENLPSVFGSNPKA

GBF1

991

Q92538
TSQSLFPSASKGLLP

KMT2A

3141

Q03164
FKVVNGQASPSPSTA

KNDC1

956

Q76NI1
VSFSAGLTQKPFPSD

EMILIN2

906

Q9BXX0
NLTELKSFGSPPLAV

DNAH9

3171

Q9NYC9
KSFGSPPLAVSNVSA

DNAH9

3176

Q9NYC9
QVPLNPFSFTLSGKS

ESRG

191

Q1W209
GKFLAAARNPAAEPS

GOLGA8B

506

A8MQT2
ANVFKQPPATTTGAA

BICRA

421

Q9NZM4
NLPTLNVAKAASSGP

BICRA

1041

Q9NZM4
SSPRVPGALAAAKAA

ELN

641

P15502
GLPSTTFKLPSNSLG

RPRD2

616

Q5VT52
AKASDGSVPLPLQFL

CFAP47

2271

Q6ZTR5
PSKQAGLSSAIAPFS

CAMSAP2

946

Q08AD1
LQSKLSSSGAPPADF

HELB

951

Q8NG08
PSVLDFPSSATGLKG

NEURL4

111

Q96JN8
IGFPSTTPAKAKANA

CLIP1

281

P30622
VAVFKAASPLGSPEL

FOCAD

1491

Q5VW36
PRAGASPATSKTLAF

FEZF2

16

Q8TBJ5
PASQPVVKALFGASA

CDC25A

21

P30304
RATAKSFVKPPSLAN

NAV1

786

Q8NEY1
FAKVNSISPGSPASI

PSMD9

136

O00233
GKISFPAIQAAPSFS

WARS1

276

P23381
PAVLPGTKALSAVSA

TAF4

796

O00268
AAPAEPGSKYSLASL

REXO1

171

Q8N1G1
LNAPPGTSLISFSDK

AGXT

211

P21549
DGFSPKPVTLLASLF

TRNT1

286

Q96Q11
AALSPAAGKVPQASA

AHCYL2

71

Q96HN2
LKSGGPDAFTSFPTQ

TMEM132B

861

Q14DG7
ALEPAFGKISPLSAD

TCP10L

121

Q8TDR4
LSPAFPSLIKNTGVA

SPATA31A6

506

Q5VVP1
PGKNIFFSPLSISAA

SERPINA4

71

P29622
KSFAALEAAAPIQPT

NEXMIF

36

Q5QGS0
VKPLGPTAAFSASQI

PIP5K1C

466

O60331
ATSLGNSAFPLAALP

PRR36

471

Q9H6K5
AAKFPEAVLAAGLTP

THNSL2

421

Q86YJ6
PAAKSAFGQLPSCAT

PPP1R26

971

Q5T8A7
ADKISSSFSKGQPLP

SEC31B

346

Q9NQW1
TSVGQSGFPKPLTAL

SEC23IP

106

Q9Y6Y8
LSFPQSKANLASVAP

SLC10A5

386

Q5PT55
AKTALPAQSAATLPA

SPTBN1

2176

Q01082
ALGKLKPNTPFAATS

TGM3

456

Q08188
ASSKNAFPLGAPTLV

ANKHD1

1801

Q8IWZ3
DGNRPSSAASAFKVP

CLASP2

16

O75122
LAPAPSKGQTLDGTF

C15orf39

176

Q6ZRI6
FSPAPKATLILNSIG

TCF19

166

Q9Y242
DAIPSLNPFLTKSSG

PICALM

431

Q13492
GAPSKVDSSFQLPAK

INPP5J

31

Q15735
AGPSAQAALPTKATK

TNRC18

2691

O15417
ALTQSPLLFQGKTPS

TICRR

1846

Q7Z2Z1
KVLGSRDPPASAFQS

TVP23C

166

Q96ET8
FKLPPGATAATATER

ZNF771

296

Q7L3S4
VTPTASFKPLGLAND

PIGT

151

Q969N2
SSVLKAFPDSPGLNR

SPR

136

P35270
ASGCPLFFPLSKLQS

TRAF1

381

Q13077
ASKAVGEPPLFLAAS

XDH

1256

P47989
FAVPAPLDNKGTNSS

RFX7

1046

Q2KHR2
SPPKEFLLGSSSAQA

SYNGR4

131

O95473
KSFPAAAVLPTGAAR

VPS37D

191

Q86XT2
GFASPKIDSVAAQPT

NUP153

616

P49790
PTVSSENFILPKGAA

ZNF644

101

Q9H582
APPAGTAASSKAVLF

ULK2

711

Q8IYT8
RAAGNSEFTLPAPSK

UBN1

686

Q9NPG3
ALLLAFLPPASQKSS

TRGV8

6

A0A0C4DH27
FLPPASQKSSNLEGR

TRGV8

11

A0A0C4DH27
SPTGNISSAPKDFAV

SUN1

701

O94901
FRPGFSPTADSLALK

TEX15

781

Q9BXT5
TAAAQPLKAKTSLPA

TKFC

456

Q3LXA3
TFSGSAANAKLNPTP

PTPRC

126

P08575
KPSASFGSPVQSEAL

UHRF1BP1

751

Q6BDS2
SGFAPGFVALSVLPK

MST1R

226

Q04912
LINSKPSVFHGPSQA

TOX

351

O94900
SSSPSPALNGVRKDF

SOCS6

161

O14544
LGATVDAPAAKPLAS

ZNF467

391

Q7Z7K2
TPAGLSTSADGFLKP

KMT2D

2131

O14686