Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	SI MGAM MGAM2	4.10e-08	5	33	3	GO:0004558
GeneOntologyMolecularFunction	alpha-glucosidase activity	SI MGAM MGAM2	1.43e-07	7	33	3	GO:0090599
GeneOntologyMolecularFunction	glucosidase activity	SI MGAM MGAM2	1.85e-06	15	33	3	GO:0015926
GeneOntologyMolecularFunction	glucan 1,4-alpha-glucosidase activity	MGAM MGAM2	2.65e-06	2	33	2	GO:0004339
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	SI MGAM ACER3 MGAM2 TLR2	3.67e-06	144	33	5	GO:0016798
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	SI MGAM ACER3 MGAM2	2.44e-05	103	33	4	GO:0004553
GeneOntologyMolecularFunction	monoatomic ion channel activity	SLC9C1 TRPM1 PIEZO2 CNGA4 CHRNA3	8.76e-04	459	33	5	GO:0005216
GeneOntologyMolecularFunction	channel activity	SLC9C1 TRPM1 PIEZO2 CNGA4 CHRNA3	1.59e-03	525	33	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC9C1 TRPM1 PIEZO2 CNGA4 CHRNA3	1.60e-03	526	33	5	GO:0022803
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM1 PIEZO2 CNGA4 CHRNA3	2.36e-03	343	33	4	GO:0005261
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC9C1 TRPM1 PIEZO2 CNGA4 CHRNA3	4.39e-03	664	33	5	GO:0008324
GeneOntologyMolecularFunction	transporter activity	ATP9B SLC9C1 TRPM1 PIEZO2 ABCA13 CNGA4 CHRNA3	4.45e-03	1289	33	7	GO:0005215
GeneOntologyBiologicalProcess	disaccharide catabolic process	SI MGAM	1.58e-05	4	34	2	GO:0046352
Domain	NtCtMGAM_N	SI MGAM MGAM2	1.83e-08	4	32	3	PF16863
Domain	Gal_mutarotase_N	SI MGAM MGAM2	1.83e-08	4	32	3	IPR031727
Domain	Glyco_hydro_31_AS	SI MGAM MGAM2	9.11e-08	6	32	3	IPR030458
Domain	Glyco_hydro_31	SI MGAM MGAM2	1.59e-07	7	32	3	PF01055
Domain	Glyco_hydro_31	SI MGAM MGAM2	1.59e-07	7	32	3	IPR000322
Domain	GLYCOSYL_HYDROL_F31_1	SI MGAM MGAM2	1.59e-07	7	32	3	PS00129
Domain	Trefoil	SI MGAM MGAM2	2.54e-07	8	32	3	PF00088
Domain	P_TREFOIL_2	SI MGAM MGAM2	3.81e-07	9	32	3	PS51448
Domain	PD	SI MGAM MGAM2	3.81e-07	9	32	3	SM00018
Domain	-	SI MGAM MGAM2	7.47e-07	11	32	3	4.10.110.10
Domain	P_trefoil_dom	SI MGAM MGAM2	9.95e-07	12	32	3	IPR000519
Domain	Gal_mutarotase_SF_dom	SI MGAM MGAM2	3.06e-06	17	32	3	IPR011013
Domain	Glyco_hydro_31_CS	SI MGAM	1.70e-05	4	32	2	IPR030459
Domain	GLYCOSYL_HYDROL_F31_2	SI MGAM	2.83e-05	5	32	2	PS00707
Domain	P_TREFOIL_1	SI MGAM	7.91e-05	8	32	2	PS00025
Domain	P_trefoil_CS	SI MGAM	7.91e-05	8	32	2	IPR017957
Domain	Glycoside_hydrolase_SF	SI MGAM MGAM2	1.01e-04	53	32	3	IPR017853
Domain	Ion_trans_dom	SLC9C1 TRPM1 CNGA4	9.66e-04	114	32	3	IPR005821
Domain	Ion_trans	SLC9C1 TRPM1 CNGA4	9.66e-04	114	32	3	PF00520
Domain	CNMP_BINDING_1	SLC9C1 CNGA4	1.37e-03	32	32	2	PS00888
Domain	CNMP_BINDING_2	SLC9C1 CNGA4	1.37e-03	32	32	2	PS00889
Domain	cNMP	SLC9C1 CNGA4	1.54e-03	34	32	2	SM00100
Domain	cNMP_binding	SLC9C1 CNGA4	1.54e-03	34	32	2	PF00027
Domain	cNMP-bd_dom	SLC9C1 CNGA4	1.63e-03	35	32	2	IPR000595
Domain	CNMP_BINDING_3	SLC9C1 CNGA4	1.63e-03	35	32	2	PS50042
Domain	cNMP-bd-like	SLC9C1 CNGA4	1.92e-03	38	32	2	IPR018490
Domain	-	SLC9C1 CNGA4	3.05e-03	48	32	2	2.60.120.10
Domain	RmlC-like_jellyroll	SLC9C1 CNGA4	3.44e-03	51	32	2	IPR014710
Domain	7TM_GPCR_Srsx	GPR12 BRS3	1.57e-02	112	32	2	SM01381
Pathway	REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE	SI MGAM	9.82e-05	8	27	2	MM14717
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION_AMYLASE_	MGAM MGAM2	1.26e-04	9	27	2	M47622
Pathway	REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE	SI MGAM	1.92e-04	11	27	2	M1091
Pubmed	Interaction between the α-glucosidases, sucrase-isomaltase and maltase-glucoamylase, in human intestinal brush border membranes and its potential impact on disaccharide digestion.	SI MGAM	9.28e-07	2	34	2	36968271
Pubmed	Contribution of the Individual Small Intestinal α-Glucosidases to Digestion of Unusual α-Linked Glycemic Disaccharides.	SI MGAM	9.28e-07	2	34	2	27480812
Pubmed	Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.	SI MGAM	9.28e-07	2	34	2	20356844
Pubmed	Partial characterization of murine intestinal maltase-glucoamylase.	SI MGAM	2.78e-06	3	34	2	12150962
Pubmed	Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors.	PIEZO2 CHRNA3	2.78e-06	3	34	2	29241539
Pubmed	Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway.	PTK2 TLR2	5.56e-06	4	34	2	19635908
Pubmed	Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.	IMMT TLR2	5.56e-06	4	34	2	31379806
Pubmed	Cross talk between MyD88 and focal adhesion kinase pathways.	PTK2 TLR2	9.26e-06	5	34	2	15905587
Pubmed	An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents.	PIEZO2 GLP1R	7.19e-05	13	34	2	32259485
Pubmed	A vagal reflex evoked by airway closure.	PIEZO2 GLP1R	1.10e-04	16	34	2	38448588
Pubmed	A multidimensional coding architecture of the vagal interoceptive system.	PIEZO2 GLP1R	1.41e-04	18	34	2	35296859
Pubmed	The human T-cell receptor gamma (TRG) genes.	TRGC2 TRGV2	2.12e-04	22	34	2	2527426
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	ACER3 CERS4	3.21e-04	27	34	2	23096701
Pubmed	Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.	PIEZO2 GLP1R	3.70e-04	29	34	2	37192624
Cytoband	7p14	TRGC2 TRGV2	2.29e-04	30	34	2	7p14
GeneFamily	T cell receptor gamma locus at 7p14	TRGC2 TRGV2	2.65e-04	22	20	2	375
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GPR12 PTK2	1.68e-02	181	20	2	694
Drug	Copper silicide	SI MGAM	6.11e-06	3	33	2	CID006336988
Drug	Acarbose	SI MGAM	1.22e-05	4	33	2	DB00284
Drug	nimbidiol	SI MGAM	1.22e-05	4	33	2	ctd:C496111
Drug	(2S,3R)-Sphingosine	GPR12 TRPM1 ACER3 CHRNA3 CERS4 PTK2	1.79e-05	389	33	6	CID000001104
Drug	AC1L53LJ	SI MGAM	2.03e-05	5	33	2	CID000197521
Drug	AC1OCFTL	SI MGAM	3.04e-05	6	33	2	CID006918743
Drug	PD165929	BRS3 PTK2	4.26e-05	7	33	2	CID005311352
Drug	isomaltotetraose	SI MGAM	4.26e-05	7	33	2	CID003080783
Drug	Glycan	SI MGAM PIGB TLR2	6.06e-05	148	33	4	CID000000871
Disease	1,5 anhydroglucitol measurement	SI MGAM MGAM2	4.15e-06	29	32	3	EFO_0008009
Disease	lung small cell carcinoma (is_marker_for)	CHRNA3 PTK2	1.35e-04	16	32	2	DOID:5409 (is_marker_for)
Disease	esophageal carcinoma, gastric carcinoma	TRPM1 EPG5	1.53e-04	17	32	2	EFO_0000178, EFO_0002916
Disease	progression free survival, ovarian serous carcinoma	MGAM ABCA13	2.60e-04	22	32	2	EFO_0004920, EFO_1001516
Disease	lung small cell carcinoma (is_implicated_in)	CHRNA3 PTK2	4.23e-04	28	32	2	DOID:5409 (is_implicated_in)
Disease	bullous pemphigoid	FMN2 TLR2	6.25e-04	34	32	2	EFO_0007187
Disease	response to hydrochlorothiazide, triglyceride measurement	FMN2 PIEZO2	1.19e-03	47	32	2	EFO_0004530, EFO_0005202
Disease	Alcohol abuse	CHRNA3 TLR2	2.41e-03	67	32	2	C0085762
Disease	Schizophrenia	TRPM1 ABCA13 CHRNA3 ADCY7 TLR2	2.44e-03	883	32	5	C0036341
Disease	Cardiomyopathies, Primary	TLR2 EPG5	2.55e-03	69	32	2	C0033141
Disease	Myocardial Diseases, Secondary	TLR2 EPG5	2.55e-03	69	32	2	C0036529
Disease	carotid plaque build	PIGB EPG5	3.76e-03	84	32	2	EFO_0006501

Protein segments in the cluster

Peptide	Gene	Start	Entry
IFYYSVLLLTLYTVL	TMEM62	481	Q0P6H9
SYLTLYVYLLQCLNS	EPG5	2371	Q9HCE0
HILFSLYTRTLYLRY	ACER3	231	Q9NUN7
RLVLFPTQILYTTYY	CERS4	276	Q9HA82
ITYSLYIRRLPLFYT	CHRNA3	231	P32297
LLAITVDRYLSLYYA	GPR12	131	P47775
LLQIYSSFYRYIYEL	ABCA13	961	Q86UQ4
LLRYFYRQLLLFYSK	ADAD1	281	Q96M93
LYLQLYDSSRTLYAF	DOP1A	1371	Q5JWR5
FYITLLTLSRQIDYY	ADCY7	806	P51828
YLNIRYTLLPYLYTL	MGAM2	661	Q2M2H8
YYQLSLRSYRLSLQV	HIPK4	361	Q8NE63
LLFLYIIYTVGYALS	GLP1R	141	P43220
YRNLFRFLLLFSYII	ATP9B	406	O43861
RYTLLPYLYTLFFRA	MGAM	716	O43451
YQYFLSYLQSLLLFP	IMMT	656	Q16891
QELLYIYYQILSLLT	MON1A	331	Q86VX9
SRSLLSYIVSYYLRN	FMN2	1531	Q9NZ56
LYLNYCSNISFYLIL	UTP3	271	Q9NQZ2
LFSYYNITLAKRYIS	SCAP	636	Q12770
TLLNLYFYLRLIYST	MT-ND2	286	P03891
YFYLRLIYSTSITLL	MT-ND2	291	P03891
RLRSYTYPLIFASIY	PIGB	111	Q92521
DIYYSLNIYLTLIVL	SLC9C1	326	Q4G0N8
LLQLTNTSAYYTYLL	TRGC2	146	P03986
NTSAYYTYLLLLLKS	TRGC2	151	P03986
YYTYASTRNNLRLIL	TRGV2	86	A0A075B6R0
YSLDLASLILYAYQL	PTK2	516	Q05397
RQYLTIRYTLLPFLY	SI	686	P14410
NILNIRYTLLPYFYT	SI	1581	P14410
ITSLLAYRAYELTQY	TASOR	286	Q9UK61
YYSLIARTLYKSTLN	BRS3	236	P32247
RQYLYSFYFSTLILT	CNGA4	216	Q8IV77
YRYFYLFILSLSLLT	ZDHHC9	181	Q9Y397
RYNGLSFVYLIYLLL	PIEZO2	26	Q9H5I5
ISYLGYLLLFNYVIL	TRPM1	836	Q7Z4N2
RFYLFYDLSTLYSLT	TLR2	321	O60603
LVTLSYIYFNYLTRI	TMEM236	326	Q5W0B7
YIYFNYLTRIRIFSA	TMEM236	331	Q5W0B7