Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	ribonuclease III complex	DROSHA DGCR8	6.37e-05	3	97	2	GO:1903095
GeneOntologyCellularComponent	microprocessor complex	DROSHA DGCR8	6.37e-05	3	97	2	GO:0070877
Domain	ARM-like	COPB1 NEK10 KPNA6 ARMC9 WDFY4 ANKAR ASPM PKP1 DAAM2 TARBP1	1.55e-06	270	98	10	IPR011989
Domain	ARM-type_fold	RALGAPA1 COPB1 NEK10 KPNA6 ARMC9 WDFY4 ANKAR ASPM PKP1 DAAM2 TARBP1	1.64e-06	339	98	11	IPR016024
Domain	-	COPB1 NEK10 KPNA6 ARMC9 WDFY4 ANKAR ASPM PKP1 DAAM2	2.53e-06	222	98	9	1.25.10.10
Domain	ARM_REPEAT	NEK10 KPNA6 ANKAR PKP1	5.63e-05	40	98	4	PS50176
Domain	RUN	SGSM1 SNX29 RUBCN	1.08e-04	18	98	3	SM00593
Domain	RUN	SGSM1 SNX29 RUBCN	1.28e-04	19	98	3	PS50826
Domain	RUN	SGSM1 SNX29 RUBCN	1.28e-04	19	98	3	PF02759
Domain	Run_dom	SGSM1 SNX29 RUBCN	1.28e-04	19	98	3	IPR004012
Domain	ZF_UBR	UBR5 UBR3	5.63e-04	7	98	2	PS51157
Domain	zf-UBR	UBR5 UBR3	5.63e-04	7	98	2	PF02207
Domain	Znf_UBR	UBR5 UBR3	5.63e-04	7	98	2	IPR003126
Domain	ZnF_UBR1	UBR5 UBR3	5.63e-04	7	98	2	SM00396
Domain	Arm	KPNA6 ANKAR PKP1	5.66e-04	31	98	3	PF00514
Domain	ARM	KPNA6 ANKAR PKP1	1.20e-03	40	98	3	SM00185
Domain	Armadillo	KPNA6 ANKAR PKP1	1.92e-03	47	98	3	IPR000225
Domain	KRAB	ZNF586 ZNF776 ZNF792 ZNF587 ZNF552 ZNF418 ZNF417	2.79e-03	358	98	7	PS50805
Domain	KRAB	ZNF586 ZNF776 ZNF792 ZNF587 ZNF552 ZNF418 ZNF417	2.79e-03	358	98	7	PF01352
Domain	KRAB	ZNF586 ZNF776 ZNF792 ZNF587 ZNF552 ZNF418 ZNF417	3.30e-03	369	98	7	SM00349
Domain	KRAB	ZNF586 ZNF776 ZNF792 ZNF587 ZNF552 ZNF418 ZNF417	3.35e-03	370	98	7	IPR001909
Domain	DSRM	DROSHA DGCR8	4.40e-03	19	98	2	SM00358
Domain	dsrm	DROSHA DGCR8	4.87e-03	20	98	2	PF00035
Domain	DS_RBD	DROSHA DGCR8	5.36e-03	21	98	2	PS50137
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	COPB1 HECTD4 DYRK1A IST1 CHD9 KPNA6 ZFC3H1 TMEM168 DROSHA DAAM2 NR1H2 DGCR8 WDR17 GEN1 TARBP1 ALPL	9.15e-07	1285	101	16	35914814
Pubmed	Global miRNA dosage control of embryonic germ layer specification.	DROSHA DGCR8	8.35e-06	2	101	2	33953397
Pubmed	Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design.	GPR35 NOS3	8.35e-06	2	101	2	18271057
Pubmed	Cellular functions of the microprocessor.	DROSHA DGCR8	8.35e-06	2	101	2	23863141
Pubmed	Posttranscriptional crossregulation between Drosha and DGCR8.	DROSHA DGCR8	8.35e-06	2	101	2	19135890
Pubmed	Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci.	DROSHA DGCR8	8.35e-06	2	101	2	32302542
Pubmed	Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.	DROSHA DGCR8	8.35e-06	2	101	2	19759829
Pubmed	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.	DROSHA DGCR8	8.35e-06	2	101	2	29170488
Pubmed	The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.	DROSHA DGCR8	8.35e-06	2	101	2	15589161
Pubmed	Schizophrenia is associated with an increase in cortical microRNA biogenesis.	DROSHA DGCR8	8.35e-06	2	101	2	19721432
Pubmed	Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.	DROSHA DGCR8	8.35e-06	2	101	2	28155978
Pubmed	The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor.	DROSHA DGCR8	8.35e-06	2	101	2	31956890
Pubmed	The Microprocessor complex mediates the genesis of microRNAs.	DROSHA DGCR8	8.35e-06	2	101	2	15531877
Pubmed	The Microprocessor controls the activity of mammalian retrotransposons.	DROSHA DGCR8	8.35e-06	2	101	2	23995758
Pubmed	Functional Anatomy of the Human Microprocessor.	DROSHA DGCR8	8.35e-06	2	101	2	26027739
Pubmed	Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.	TBK1 WIPI2	8.35e-06	2	101	2	27370208
Pubmed	DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.	DROSHA DGCR8	8.35e-06	2	101	2	22796965
Pubmed	The Drosha-DGCR8 complex in primary microRNA processing.	DROSHA DGCR8	8.35e-06	2	101	2	15574589
Pubmed	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor.	DROSHA DGCR8	8.35e-06	2	101	2	32317642
Pubmed	A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.	DROSHA DGCR8	8.35e-06	2	101	2	26683315
Pubmed	Association of miRNA biosynthesis genes DROSHA and DGCR8 polymorphisms with cancer susceptibility: a systematic review and meta-analysis.	DROSHA DGCR8	8.35e-06	2	101	2	29654164
Pubmed	Molecular determinants that govern scaRNA processing by Drosha/DGCR8.	DROSHA DGCR8	8.35e-06	2	101	2	33037012
Pubmed	Structural Basis for pri-miRNA Recognition by Drosha.	DROSHA DGCR8	8.35e-06	2	101	2	32220645
Pubmed	Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.	DROSHA DGCR8	8.35e-06	2	101	2	32220646
Pubmed	Inflammation induced changes in the expression levels of components of the microRNA maturation machinery Drosha, Dicer, Drosha co-factor DGRC8 and Exportin-5 in inflammatory lesions of hidradenitis suppurativa patients.	DROSHA DGCR8	8.35e-06	2	101	2	26917346
Pubmed	Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes.	DROSHA DGCR8	8.35e-06	2	101	2	22393237
Pubmed	Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.	MED16 MED31 CCNC	1.88e-05	18	101	3	10198638
Pubmed	Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.	DROSHA DGCR8	2.50e-05	3	101	2	25439752
Pubmed	The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.	DROSHA DGCR8	2.50e-05	3	101	2	36950067
Pubmed	Cell cycle-dependent regulation of Aurora kinase B mRNA by the Microprocessor complex.	DROSHA DGCR8	2.50e-05	3	101	2	24589731
Pubmed	The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.	DROSHA DGCR8	2.50e-05	3	101	2	30295958
Pubmed	Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.	DROSHA DGCR8	2.50e-05	3	101	2	32124011
Pubmed	Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.	DROSHA DGCR8	2.50e-05	3	101	2	27173348
Pubmed	Transcript Level of MicroRNA Processing Elements in Gastric Cancer.	DROSHA DGCR8	2.50e-05	3	101	2	30168106
Pubmed	Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease.	DROSHA DGCR8	2.50e-05	3	101	2	23663110
Pubmed	Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury.	MLKL RUBCN	2.50e-05	3	101	2	35288534
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	COPB1 MED16 MED31 NELFB BAZ1B CHD9 EIF3CL CCNC POLR3C	2.61e-05	533	101	9	30554943
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	COPB1 BAZ1B GPAM RFX8 SNX25 WDR17	2.63e-05	199	101	6	31146259
Pubmed	Requirement of argininosuccinate lyase for systemic nitric oxide production.	ASL NOS3	4.99e-05	4	101	2	22081021
Pubmed	Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.	DROSHA DGCR8	4.99e-05	4	101	2	22222205
Pubmed	Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.	DROSHA DGCR8	4.99e-05	4	101	2	25670082
Pubmed	Modulation of microRNA processing by p53.	DROSHA DGCR8	4.99e-05	4	101	2	19626115
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MMS22L POLE MED31 NELFB ZFC3H1 CCNC UBR5 DGCR8	5.47e-05	453	101	8	29656893
Pubmed	miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.	DROSHA DGCR8	8.30e-05	5	101	2	27880903
Pubmed	Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.	DROSHA DGCR8	8.30e-05	5	101	2	25670083
Pubmed	Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.	DROSHA DGCR8	8.30e-05	5	101	2	25707934
Pubmed	BRG1 and SMARCAL1 transcriptionally co-regulate DROSHA, DGCR8 and DICER in response to doxorubicin-induced DNA damage.	DROSHA DGCR8	8.30e-05	5	101	2	28716689
Pubmed	NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.	DROSHA DGCR8	8.30e-05	5	101	2	28846091
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	POLE SNX29 PTPN14 FARP1 TBK1 CEP97	9.52e-05	251	101	6	29778605
Pubmed	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.	MED16 MED31 CCNC	1.01e-04	31	101	3	23322298
Pubmed	Protein interaction network of alternatively spliced NudCD1 isoforms.	COPB1 DHX15	1.24e-04	6	101	2	29021621
Pubmed	SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.	DROSHA DGCR8	1.24e-04	6	101	2	29020972
Pubmed	Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.	ETF1 RNF25	1.24e-04	6	101	2	27863242
Pubmed	Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.	DGCR8 TARBP1	1.24e-04	6	101	2	22025453
Pubmed	Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems.	DROSHA DGCR8	1.74e-04	7	101	2	28819115
Pubmed	The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.	DROSHA DGCR8	1.74e-04	7	101	2	26965827
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF776 ZNF792 ZNF587 ZNF552 ZNF417	1.91e-04	181	101	5	37372979
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	SEPTIN9 PKD1L1 DYRK1A IST1 PTPN14 UBR5 FARP1 TBK1 FHIP1A CEP97	1.92e-04	853	101	10	28718761
Pubmed	The protein interaction landscape of the human CMGC kinase group.	MARCHF10 MED16 MED31 DYRK1A CCNC DHX15 DROSHA DGCR8 CEP97	1.97e-04	695	101	9	23602568
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MED16 MED31 CCNC	2.01e-04	39	101	3	38690566
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	COPB1 SEPTIN9 POLE NELFB BAZ1B KPNA6 MRPS10 UBR5 PCYT2	2.16e-04	704	101	9	29955894
Pubmed	An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.	ETF1 RNF25	2.31e-04	8	101	2	36638793
Pubmed	The LIFEdb database in 2006.	AHI1 COPB1 NELFB GPAM ARMC9 ANKRD27 FARP1 DGCR8 WIPI2	2.55e-04	720	101	9	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	AHI1 COPB1 NELFB GPAM ARMC9 ANKRD27 FARP1 DGCR8 WIPI2	2.60e-04	722	101	9	15489336
Pubmed	Delayed osteoblastic differentiation and bone development in Cx43 knockout mice.	GJA3 ALPL	2.97e-04	9	101	2	21934140
Pubmed	Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.	DROSHA DGCR8	2.97e-04	9	101	2	24581491
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR5 UBR3	2.97e-04	9	101	2	17855541
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BAZ1B KPNA6 POLR3C PTPN14 UBR5 DROSHA TBK1 ASPM	3.25e-04	588	101	8	38580884
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	MED16 MED31 CCNC	3.51e-04	47	101	3	15175163
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	DROSHA DGCR8	3.70e-04	10	101	2	20721975
Pubmed	Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain.	DROSHA DGCR8	4.51e-04	11	101	2	22897173
Pubmed	DNA cloning using in vitro site-specific recombination.	AHI1 COPB1 NELFB GPAM ARMC9 ANKRD27 FARP1 DGCR8 WIPI2	5.18e-04	794	101	9	11076863
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR5 UBR3	5.41e-04	12	101	2	17360488
Pubmed	Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins.	DROSHA DGCR8	6.38e-04	13	101	2	17765891
Pubmed	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response.	KPNA6 TBK1	6.38e-04	13	101	2	34950606
Pubmed	CDK8 is a positive regulator of transcriptional elongation within the serum response network.	MED16 CCNC	6.38e-04	13	101	2	20098423
Pubmed	Replication of recently described type 2 diabetes gene variants in a South Indian population.	AHI1 BAZ1B	6.38e-04	13	101	2	20580033
Pubmed	Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.	DROSHA DGCR8	7.43e-04	14	101	2	20585341
Pubmed	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.	DROSHA DGCR8	7.43e-04	14	101	2	21297615
Pubmed	A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.	MED31 CCNC	7.43e-04	14	101	2	10024883
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MED16 POLE ETF1 NELFB BAZ1B CHD9 CCNC POLR3C DHX15 UBR5	7.44e-04	1014	101	10	32416067
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ERAP1 SEPTIN9 NELFB IST1 XKR7 PKP1 DGKI TARBP1	9.15e-04	689	101	8	36543142
Pubmed	Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.	UBR5 ASPM	9.76e-04	16	101	2	29764992
Pubmed	The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.	MED16 CCNC	9.76e-04	16	101	2	10882111
Pubmed	Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.	MED16 CCNC	1.10e-03	17	101	2	10235266
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	GPAM NR1H2	1.10e-03	17	101	2	17496333
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	COPB1 SEPTIN9 NELFB PTPN14 UBR5 FARP1	1.11e-03	399	101	6	37536630
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	DYRK1A EIF3CL TBK1	1.13e-03	70	101	3	34255829
Pubmed	Streamlined analysis schema for high-throughput identification of endogenous protein complexes.	MED16 MED31 CCNC	1.18e-03	71	101	3	20133760
Pubmed	Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.	DROSHA DGCR8	1.24e-03	18	101	2	19047128
Pubmed	Human mediator subunit MED26 functions as a docking site for transcription elongation factors.	MED16 MED31 CCNC	1.28e-03	73	101	3	21729782
Pubmed	TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.	MLKL TBK1	1.38e-03	19	101	2	30146158
Pubmed	Androglobin, a chimeric mammalian globin, is required for male fertility.	SEPTIN9 NOS3	1.38e-03	19	101	2	35700329
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BAZ1B CHD9 KPNA6 MLKL PTPN14 UBR5 DROSHA TBK1 ASPM ALPL	1.53e-03	1116	101	10	31753913
Pubmed	Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.	MED16 CCNC	1.53e-03	20	101	2	15340084
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	BAZ1B ASPM	1.69e-03	21	101	2	22154806
Pubmed	Network organization of the human autophagy system.	SEPTIN9 FREM1 TBK1 PKP1 RUBCN WIPI2	1.77e-03	437	101	6	20562859
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	COPB1 SEPTIN9 DHX15 TBK1 ALPL	1.81e-03	298	101	5	30737378
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MED16 HECTD4 DYRK1A KPNA6 ZFC3H1 UBR5	1.83e-03	440	101	6	34244565
Pubmed	Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway.	BAZ1B TBK1	1.86e-03	22	101	2	32241891
Cytoband	19q13.43	ZNF586 ZNF776 ZNF587 ZNF552 ZNF418 ZNF417	4.26e-08	87	101	6	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF586 ANKRD27 ZNF776 ZNF792 ZNF587 ZNF552 NR1H2 FBXO27 ZNF418 ZNF417	3.05e-04	1192	101	10	chr19q13
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	KPNA6 ARMC9 ANKAR PKP1	1.40e-05	43	62	4	409
GeneFamily	Cyclins\|Mediator complex	MED16 MED31 CCNC	1.95e-04	33	62	3	1061
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR5 UBR3	2.40e-04	7	62	2	785
GeneFamily	SPOUT methyltranferase domain containing	TRMT10A TARBP1	3.20e-04	8	62	2	1294
GeneFamily	WD repeat domain containing	AHI1 MED16 WDFY4 WDR17 WIPI2	2.03e-03	262	62	5	362
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX29 SNX25	4.43e-03	29	62	2	754
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MMS22L RBM44 ASPM SND1-IT1 GEN1 RUBCN	4.76e-06	190	101	6	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MMS22L RBM44 ASPM SND1-IT1 GEN1 RUBCN	5.06e-06	192	101	6	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ID3 BAZ1B CHD9 GPAM ASPM ALPL	5.36e-06	194	101	6	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AHI1 CHD9 WDFY4 SNX29 GEN1 RUBCN	5.36e-06	194	101	6	d852aebf7a763b9a776c4570711f0c759f591910
Disease	Portal Hypertension	KCNN3 NOS3	9.77e-05	5	93	2	C0020541
Disease	diastolic blood pressure, alcohol drinking	NEK10 HECTD4 NPRL3 NOS3	5.39e-04	118	93	4	EFO_0004329, EFO_0006336
Disease	systolic blood pressure, alcohol drinking	NEK10 HECTD4 NPRL3 NOS3	7.32e-04	128	93	4	EFO_0004329, EFO_0006335
Disease	Vertigo	AHI1 ARMC9 RFX8 DROSHA	9.95e-04	139	93	4	HP_0002321
Disease	mean arterial pressure	MMS22L ERAP1 SEPTIN9 HECTD4 PPL NPRL3 NOS3	1.03e-03	499	93	7	EFO_0006340
Disease	autism spectrum disorder (is_implicated_in)	AHI1 DYRK1A	1.15e-03	16	93	2	DOID:0060041 (is_implicated_in)
Disease	Benign neoplasm of stomach	POLE UBR5	1.30e-03	17	93	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	POLE UBR5	1.30e-03	17	93	2	C0496905
Disease	Carcinoma in situ of stomach	POLE UBR5	1.30e-03	17	93	2	C0154060
Disease	chromosomal aberration frequency	COPB1 UBR5	1.45e-03	18	93	2	EFO_0009860
Disease	Joubert syndrome 1	AHI1 ARMC9	1.98e-03	21	93	2	C4551568
Disease	Stomach Carcinoma	POLE UBR5	1.98e-03	21	93	2	C0699791
Disease	Primary microcephaly	TRMT10A ASPM	2.18e-03	22	93	2	C0431350
Disease	Hodgkins lymphoma	AHI1 ERAP1 SLC18A3	2.24e-03	82	93	3	EFO_0000183
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	FREM1 NOS3	2.59e-03	24	93	2	DOID:3827 (biomarker_via_orthology)
Disease	visuospatial function measurement	DYRK1A FARP1	3.04e-03	26	93	2	EFO_0803533

Protein segments in the cluster

Peptide	Gene	Start	Entry
RVLCHTLARNMVYIL	AGBL3	326	Q8NEM8
RLMEKREVILYCDLH	AGBL3	446	Q8NEM8
INYTLRALRLVHVCM	CATSPER4	181	Q7RTX7
FMRELCGHLNIIYDL	AHI1	646	Q8N157
LQILTALCHRILMTY	BAZ1B	746	Q9UIG0
YLEHLCLVLEQMARL	C8orf58	191	Q8NAV2
ILEEQMLHEILCREY	DNHD1	3756	Q96M86
MLHEILCREYPELET	DNHD1	3761	Q96M86
RNHLCLVFEMLSYNL	DYRK1A	231	Q13627
SEVCILHEYMQRVLK	DGCR8	511	Q8WYQ5
YLEAAIRTVIQIHMC	DHX15	331	O43143
CMEYIELRHAVLVLQ	ASPM	1941	Q8IZT6
HEIRSMILHLLCDRY	CPXCR1	146	Q8N123
AELHLLNVHYQMCRR	RBM44	606	Q6ZP01
HQMIRELAIGIYCLN	ANKAR	101	Q7Z5J8
RMNHILECEFYLLEL	CCNC	131	P24863
TMCADDLLSVLLYLL	ANKRD27	306	Q96NW4
DRNISLLHYLIMILE	DAAM2	836	Q86T65
CRRLVELLMHNDYKV	KPNA6	296	O60684
NTLLTLLDCLADYIM	H2AP	51	O75409
VILEEQLRMYLHCCL	MMS22L	396	Q6ZRQ5
THLSRMAEDLILYCT	ASL	251	P04424
LEYSVALLMNLCLRS	ARMC9	476	Q7Z3E5
QCLHMLELLQYEHFR	MED31	71	Q9Y3C7
MLRSQLLLLACVHNY	ERAP1	726	Q9NZ08
MNLHERTLSVLACRY	PCYT2	266	Q99447
IVENLLMILHEYDLL	NEK10	251	Q6ZWH5
ERILYISLEMLVCAI	KCNN3	361	Q9UGI6
LSRSYCLHQDMIRLV	OR51Q1	176	Q8NH59
ILLAMALDRYVAICI	OR52A5	116	Q9H2C5
LNLLICEESHLKYME	PPL	306	O60437
DGRLLHEMILVCDAY	COPB1	91	P53618
RLLIQLHTYVCLMAS	NPRL3	401	Q12980
SCEEFLLMGLRYQHL	FREM1	236	Q5H8C1
NVHYCTLRAELLMSL	NELFB	231	Q8WX92
RMIRHYLNLDTCLSQ	POLE	1631	Q07864
LEIMLEKLRCAIHYR	HECTD4	3976	Q9Y4D8
RIYMTNLAVADLCLL	GPR35	56	Q9HC97
IVMEYCELGTLRELL	MLKL	281	Q8NB16
LRHLLFLLEYCMVTG	MED16	471	Q9Y2X0
HRYNILEDVAVCMDL	NOS3	371	P29474
YAVLMHRALCQQLVA	OR2B11	136	Q5JQS5
RYSVLMSHRVCLLLA	OR2T10	131	Q8NGZ9
CKDIAYQLMHNIRDI	ALPL	201	P05186
ELLECVYLVSAMLLE	EIF3CL	681	B5ME19
QMVRCLDILEDYLIH	CHD9	1206	Q3L8U1
GLHCEDVMLQLVLRY	FHIP1A	396	Q05DH4
LHRLMHYKQVLERLC	FARP1	686	Q9Y4F1
LHQCREVMLLTYKSI	DGKI	661	O75912
YEIRLRRMQEHIVCL	CEP97	586	Q8IW35
VLLLHLYEQRFAELM	MARCHF10	751	Q8NA82
ACEKLLVLLTHYDMI	GEN1	371	Q17RS7
VEAMEILELYCDLLL	IST1	66	P53990
LDDMNHCYSRLRELV	ID3	41	Q02535
ACASLLLNMLEIYHL	GJA3	211	Q9Y6H8
HDSGCMYRLLVQLLD	FBXO27	196	Q8NI29
RLCRDMQSILYHGLI	RUBCN	56	Q92622
LALSLIHLCVQLYRM	PKD1L1	2531	Q8TDX9
VLYTTLLCRLHAMRL	NPBWR1	221	P48145
MCVLHNLSYRLDAEV	PKP1	476	Q13835
HSLRNSCLIRMDLLY	SND1-IT1	6	Q9HBX3
VLSMHQILLYLLRCS	DROSHA	696	Q9NRR4
MRTLYRCLELEHLTG	MRPS10	136	P82664
LVIVCVALLLDNMLY	SLC18A3	36	Q16572
HSLERYLHMLLADRC	SNX29	126	Q8TEQ0
HLSNYILNLMALLCA	TCP11X1	156	B4DZS4
HLSNYILNLMALLCA	TCP11X2	61	Q5H9J9
HLLLLMFEVLVCDRV	TMEM185B	91	Q9H7F4
ERLHMCLSLQYLTVD	LRRC28	151	Q86X40
HLLYALMELLLIELC	SNX25	811	Q9H3E2
AIMSTHIVACLLLYR	GPAM	481	Q9HCL2
MLLETARRYNHETEC	NR1H2	311	P55055
LILSELMIYCLEHNE	PTPN14	1131	Q15678
VCLMSYERRQILHLI	TENT5D	311	Q8NEK8
CEFAYLRDLLIRTHM	SEPTIN9	531	Q9UHD8
VCLEESLYIHNIRDM	WIPI2	131	Q9Y4P8
CHLAIDNIELAMAYL	WDR17	966	Q8IZU2
QRCLYRDVMLETLTL	ZNF586	36	Q9NXT0
RRRMTLYHCIVLLEN	XKR7	381	Q5GH72
LDEHTDMCKRILNIY	RALGAPA1	551	Q6GYQ0
VNILSAARMLLHRCY	POLR3C	426	Q9BUI4
LLLEYMIHILQSCLE	RFX8	431	Q6ZV50
MVSQLQRECYLKHDL	STC2	131	O76061
CLARYIQHMEQELKA	RNF25	161	Q96BH1
LLSEAQRCLYRDVML	ZNF587	31	Q96SQ5
LLSEAQRCLYRDVML	ZNF417	31	Q8TAU3
LCLMHCLLLLNERSY	WDFY4	2061	Q6ZS81
HCLYLAMTRLEEVNR	TMEM168	11	Q9H0V1
MTIRLEEIVYLHCHQ	SGSM1	316	Q2NKQ1
RCLYRDVTLENLALM	ZNF552	36	Q9H707
QNLSEHVLCMVLYLI	UBR3	941	Q6ZT12
HVLCMVLYLIELGLE	UBR3	946	Q6ZT12
LLSEVQRCLYHDVML	ZNF418	21	Q8TF45
RLLYCDVMLENFALI	ZNF792	36	Q3KQV3
LRLIIDCSFDHLMVL	TRMT10A	101	Q8TBZ6
SDLDRCHLYLMVLTE	TARBP1	746	Q13395
CHLYLMVLTELINLH	TARBP1	751	Q13395
LMQRAKLYLEHCISL	VRTN	401	Q9H8Y1
LHQLLERYEAAMELC	ZFC3H1	1611	O60293
CRIASTLLLYQELMR	TBK1	426	Q9UHD2
VEKQTLMQHILRCDY	UBR5	871	O95071
NLLELIEYTHMLRVT	ATP6V0A2	121	Q9Y487
LSEAQRCLYHDVMLE	ZNF776	31	Q68DI1
RCLYHDVMLENLTLI	ZNF776	36	Q68DI1
LDIMRYVLHCQGTEE	ETF1	326	P62495
LMRLLECDVIIYNIT	AK7	106	Q96M32