Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainWWE

PARP14 TIPARP

6.34e-0412592PS50918
DomainClass_I_gatase-like

TCAF2 CAD

6.34e-0412592IPR029062
DomainWWE

PARP14 TIPARP

6.34e-0412592PF02825
DomainWWE-dom

PARP14 TIPARP

6.34e-0412592IPR004170
Domain-

MUC16 TMPRSS11B

1.00e-03155923.30.70.960
DomainPoly(ADP-ribose)pol_cat_dom

PARP14 TIPARP

1.29e-0317592IPR012317
DomainPARP_CATALYTIC

PARP14 TIPARP

1.29e-0317592PS51059
DomainPARP

PARP14 TIPARP

1.29e-0317592PF00644
Domain-

PARP14 TIPARP

1.29e-03175923.90.228.10
DomainWD40

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

1.34e-03259595PF00400
DomainWD40

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

1.56e-03268595SM00320
DomainWD40_repeat

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

1.66e-03272595IPR001680
DomainWD_REPEATS_1

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

1.83e-03278595PS00678
DomainWD_REPEATS_2

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

1.86e-03279595PS50082
DomainWD_REPEATS_REGION

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

1.86e-03279595PS50294
DomainSEA

MUC16 TMPRSS11B

2.18e-0322592PF01390
DomainSEA

MUC16 TMPRSS11B

2.38e-0323592PS50024
DomainSEA_dom

MUC16 TMPRSS11B

2.38e-0323592IPR000082
DomainWD40_repeat_dom

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

2.44e-03297595IPR017986
DomainWGR_domain

PARP14 TIPARP

2.59e-0324592IPR008893
Domain-

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

3.98e-033335952.130.10.10
DomainWD40/YVTN_repeat-like_dom

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

4.09e-03335595IPR015943
DomainTRYPSIN_HIS

PRSS35 PRSS38 TMPRSS11B

4.23e-03103593IPR018114
DomainTRYPSIN_SER

PRSS35 PRSS38 TMPRSS11B

4.59e-03106593PS00135
DomainTRYPSIN_HIS

PRSS35 PRSS38 TMPRSS11B

4.71e-03107593PS00134
DomainTRYPSIN_DOM

PRSS35 PRSS38 TMPRSS11B

5.75e-03115593PS50240
DomainPTPc

PTPN3 PTPRJ

5.77e-0336592SM00194
DomainTryp_SPc

PRSS35 PRSS38 TMPRSS11B

6.04e-03117593SM00020
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 PRKRA

1.11e-046392MM14818
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 PRKRA

2.07e-048392MM15082
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 PRKRA

2.65e-049392M27340
Pubmed

The role of PACT in the RNA silencing pathway.

AGO2 PRKRA

1.81e-05461216424907
Pubmed

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.

AGO2 PRKRA

1.81e-05461223661684
Pubmed

Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.

AGO2 PRKRA

4.52e-05661221858095
Pubmed

Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.

AGO2 PRKRA

4.52e-05661222025453
Pubmed

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.

VPS13C PSMA1

6.32e-05761237315142
Pubmed

The PARP superfamily.

PARP14 TIPARP

8.42e-05861215273990
Pubmed

Muscleblind-like 1 is required for normal heart valve development in vivo.

ACAN DCT

3.13e-041561226472242
Pubmed

Family-wide analysis of poly(ADP-ribose) polymerase activity.

PARP14 TIPARP

3.57e-041661225043379
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 ZNF605 VPS39 WDFY3 ZNF83 EIF2AK1 TUBGCP5 MITD1 PRKRA

3.84e-04128561935914814
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

SNX14 CAD AGO2 VPS39 FAM169A ECEL1 EIF2AK1 ATAD2 TUBGCP5

4.84e-04132761932694731
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF460 ZNF83

6.22e-04216127865130
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AKAP6 VPS39 WDFY3 SLC23A2

6.67e-0422561412168954
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

FBXW8 CAD MAN2B2 PTPRJ PSMA1 ECEL1

7.14e-0461361622268729
Pubmed

Genomic variants in an inbred mouse model predict mania-like behaviors.

CAD ZNF605

7.48e-042361229768498
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

TCAF2 MUC16 URB2 WDFY3 SMOC2 DCAF12L2

8.78e-0463861631182584
Pubmed

ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.

AGO2 PRKRA

8.84e-042561223622242
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

MAN2B2 ECEL1 WDFY3 MITD1 PRKRA

1.07e-0344261515815621
Pubmed

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

PTPRQ OTOG

1.11e-032861222808246
Pubmed

TBX1 is required for normal stria vascularis and semicircular canal development.

DCT OTOG

1.36e-033161231550482
Pubmed

Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear.

ACAN DCT

1.54e-033361224727668
CytobandEnsembl 112 genes in cytogenetic band chr8q24

RHPN1 AGO2 ADCK5 NTAQ1 ATAD2

1.12e-04355615chr8q24
Cytoband8q24.13

NTAQ1 ATAD2

1.06e-03366128q24.13
CytobandXq25

DCAF12L1 DCAF12L2

1.38e-0341612Xq25
CytobandEnsembl 112 genes in cytogenetic band chrXq25

DCAF12L1 DCAF12L2

1.88e-0348612chrXq25
Cytoband1q42.13

PRSS38 URB2

1.96e-03496121q42.13
Cytoband11p15.1

PSMA1 OTOG

2.93e-036061211p15.1
GeneFamilyWD repeat domain containing

FBXW8 DCAF12L1 ELP2 WDFY3 DCAF12L2

2.67e-04262405362
GeneFamilyProteases, serine

PRSS35 PRSS38 TMPRSS11B

3.63e-0463403738
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP14 TIPARP

6.36e-0417402684
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRJ PTPRQ

9.76e-0421402813
GeneFamilyFibronectin type III domain containing

PTPRJ TNN PTPRQ

5.29e-03160403555
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF132 ZNF605 ZNF33A ZNF460 ZNF83

2.03e-0271840528
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRSS35 AFF2 SMOC2 ATAD2 DCAF12L2

3.54e-06169615335619507857383c3b0b507cdf05d786ed59e585
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3|Hippocampus / BrainAtlas - Mouse McCarroll V32

GPR17 ACAN DCT OTOG

7.16e-0690614a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr|Hippocampus / BrainAtlas - Mouse McCarroll V32

GPR17 ACAN DCT OTOG

7.16e-0690614ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Npw|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DCLK3 SMOC2 TMPRSS11B CFAP65

1.76e-05113614165de4316059222f33d1e51aeff4554037c0b937
ToppCellfacs-Aorta-Heart-24m-Myeloid-professional_antigen_presenting_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS39 PNPLA7 DCT DHX34

2.09e-05118614171afacd54b2e447f9f8c4511e93ff4504cd47cc
Diseasecerebellar ataxia (implicated_via_orthology)

VPS13C PNPLA7

1.13e-048602DOID:0050753 (implicated_via_orthology)
Diseasesleep quality

AKAP6 PRSS38 OTOG

1.81e-03118603EFO_0005272
Diseasesevere acute respiratory syndrome, COVID-19

ELP2 ZNF83 EIF2AK1 SMOC2 SLC23A2

2.15e-03447605EFO_0000694, MONDO_0100096
DiseaseMental Retardation, Psychosocial

SNX14 ELP2 PRKRA

2.88e-03139603C0025363
DiseaseProfound Mental Retardation

SNX14 ELP2 PRKRA

2.88e-03139603C0020796
DiseaseMental deficiency

SNX14 ELP2 PRKRA

2.88e-03139603C0917816

Protein segments in the cluster

PeptideGeneStartEntry
SGLTYPVAHWHLIVS

URB2

731

Q14146
HSIWHVLISITFPYG

ACER1

206

Q8TDN7
HVNITSNVLRGYEHW

AFF2

1246

P51816
VLPTRLVYHFSGNHW

GPR17

111

Q13304
YPSVHPETRHWTALT

BTBD11

641

A6QL63
ELAHFPYVVVPRVHW

ADCK5

291

Q3MIX3
RTAPSIVYVPHIHVW

ATAD2

851

Q6PL18
IQGTSRPSHYHVLWD

AGO2

756

Q9UKV8
GEEHTVTHLQYVAWP

PTPN3

796

P26045
VTHLQYVAWPDHGVP

PTPN3

801

P26045
HTVLPYHWQIKRTTT

TIPARP

261

Q7Z3E1
HWLGSTYQLVDIHVT

MUC16

14291

Q8WXI7
LYNITISPEVDHVWG

PTPRJ

601

Q12913
TYTVDVPIHILGWNS

CFAP65

1381

Q6ZU64
IAWHSEVGLPVYAHI

DCAF12L2

231

Q5VW00
RYTAHQVLQHPWIET

DCLK3

601

Q9C098
QKLWEVYSGHPVQHI

FBXW8

506

Q8N3Y1
YWTIRVPGASHIHFS

KREMEN1

241

Q96MU8
PYLQTVDEWIVHGHL

TUBGCP5

471

Q96RT8
TVWSPQGRIHQIEYA

PSMA1

11

P25786
HTQWYEVNRVILHPT

PRSS38

126

A1L453
STPHRVLHNYLVWRV

ECEL1

391

O95672
HRIVLYQADGTLTPW

PNPLA7

796

Q6ZV29
AGWLADQTVRYPIHT

ACAN

201

P16112
LHWSLPSGHVERYQV

PTPRQ

26

Q9UMZ3
HVIHAVGPRWSGYEA

PARP14

876

Q460N5
HHEWTAPIGVISLYA

FAXDC2

206

Q96IV6
LQHPNIVGYHTAWIE

EIF2AK1

221

Q9BQI3
EVEGVGHWYQRIPVT

FAM169A

241

Q9Y6X4
WIEGETYQCRVTHPH

IGHE

291

P01854
VVPHSHMDVGWVYTV

MAN2B2

31

Q9Y2E5
VAWHSEVGLPVYAHI

DCAF12L1

231

Q5VU92
VTWHEIARPQIHGYD

ELP2

426

Q6IA86
YASHTQRWVVLPLHS

DHX34

401

Q14147
VIWDYHVVLLHVSSG

NTAQ1

76

Q96HA8
IHNVLSGQRWIEHYG

OSBPL7

641

Q9BZF2
VHTWRVGFFTLVHFP

OTOG

1071

Q6ZRI0
VGYHTVWGVTPALHS

NNT

511

Q13423
LWSVYVHETVLGIPR

TCAF2

781

A6NFQ2
TEVWIEDPYIRHTHQ

MITD1

116

Q8WV92
PEWISRHQYHALPAT

PIM2

206

Q9P1W9
HRGLWVPQHQSIQEY

MICU2

396

Q8IYU8
PVHDYVPVSWTALVH

RHPN1

331

Q8TCX5
PSHVTRNGEVVEAWY

AKAP6

611

Q13023
IQHWRIHTGEKPYEC

ZNF132

531

P52740
TRHQWIHTGEKPYVC

ZNF460

436

Q14592
YIHVWSINGNPIVSV

WDFY3

3191

Q8IZQ1
AYPDSRNIWHLVGIV

TMPRSS11B

371

Q86T26
NGTAELLHTEHIWYP

SLC23A2

196

Q9UGH3
YVGRVVFQVPDWLHH

SNX14

796

Q9Y5W7
GLRPGVEYTVHVWAQ

TNN

766

Q9UQP3
PDPSHTLEERVVHWY

SMOC2

341

Q9H3U7
RHVHLPAAWTEVIYL

TMEM232

91

C9JQI7
IIAVYSGHQWVDVHG

PRSS35

366

Q8N3Z0
HWYITGLRQQDIVPS

VPS13C

581

Q709C8
RVHPDYVITTQHWLG

DCT

151

P40126
VRTFPHERGNWATHV

USB1

71

Q9BQ65
YWGTTHDLTFRTPHV

CAD

921

P27708
IHHGWRLPEYTLSQE

PRKRA

136

O75569
LTRHQIIHTGWKPYE

ZNF33A

511

Q06730
PWLTANHITHTGVYL

ZNF605

156

Q86T29
SLVNHWRIHTGEKPY

ZNF83

331

P51522
IPYLEHIIHVWEETG

VPS39

601

Q96JC1