Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear matrix	KRT18 TENM1 PRKCD HNRNPU DNMT3A	2.39e-04	140	83	5	GO:0016363
GeneOntologyCellularComponent	chromosomal region	NCAPD3 ATR BRCA2 ALYREF HNRNPU KNL1 DNMT3A SEPTIN2	2.67e-04	421	83	8	GO:0098687
GeneOntologyCellularComponent	perinuclear region of cytoplasm	SNF8 KRT18 UACA ANKRD13C MYO5B OSBPL6 TENM1 PRKCD TAOK1 ROS1 PLCG2 SEPTIN2	3.07e-04	934	83	12	GO:0048471
GeneOntologyCellularComponent	cytoplasmic region	EFHC2 DNAH3 MYO5B GRIK2 HNRNPU CFAP46 SEPTIN2	5.73e-04	360	83	7	GO:0099568
GeneOntologyCellularComponent	nuclear periphery	KRT18 TENM1 PRKCD HNRNPU DNMT3A	5.99e-04	171	83	5	GO:0034399
GeneOntologyCellularComponent	sex chromosome	ATR HNRNPU DNMT3A	7.11e-04	44	83	3	GO:0000803
GeneOntologyCellularComponent	ruffle membrane	CDC37 EPB41L5 MACF1 PLCG2	9.05e-04	108	83	4	GO:0032587
GeneOntologyCellularComponent	cuticular plate	SPTAN1 PVALB	1.18e-03	13	83	2	GO:0032437
GeneOntologyCellularComponent	ruffle	CDC37 VIL1 EPB41L5 MACF1 PLCG2	1.38e-03	206	83	5	GO:0001726
GeneOntologyCellularComponent	leading edge membrane	CDC37 EPB41L5 MACF1 PLCG2 USH2A	1.50e-03	210	83	5	GO:0031256
GeneOntologyCellularComponent	cell projection membrane	CDC37 SLC6A19 EPB41L5 MACF1 PLCG2 USH2A SEPTIN2	1.63e-03	431	83	7	GO:0031253
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	EFHC2 DNAH3 GRIK2 HNRNPU CFAP46 SEPTIN2	1.65e-03	317	83	6	GO:0032838
GeneOntologyCellularComponent	spliceosomal complex	DHX15 SF3B3 PTBP2 ALYREF HNRNPU	1.66e-03	215	83	5	GO:0005681
Domain	Spectrin	TRIO SPTAN1 MACF1	1.21e-04	23	79	3	PF00435
Domain	Spectrin_repeat	TRIO SPTAN1 MACF1	2.46e-04	29	79	3	IPR002017
Domain	Spectrin/alpha-actinin	TRIO SPTAN1 MACF1	3.31e-04	32	79	3	IPR018159
Domain	SPEC	TRIO SPTAN1 MACF1	3.31e-04	32	79	3	SM00150
Domain	AlbA_2	SLFN5 SLFN14	3.66e-04	7	79	2	PF04326
Domain	Schlafen	SLFN5 SLFN14	3.66e-04	7	79	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN5 SLFN14	3.66e-04	7	79	2	IPR007421
Domain	Kinase-like_dom	ATR TRIO MACF1 PRKCD TAOK1 ROS1 RIPK4 MAP4K4	2.05e-03	542	79	8	IPR011009
Domain	SH3	ARHGEF19 TRIO SPTAN1 MACF1 PLCG2	2.22e-03	216	79	5	PS50002
Domain	SH3_domain	ARHGEF19 TRIO SPTAN1 MACF1 PLCG2	2.41e-03	220	79	5	IPR001452
Domain	Ank	ANKRD31 ANKS6 UACA ANKRD13C RIPK4	2.81e-03	228	79	5	PF00023
Domain	EF-hand_1	EFHC2 SPTAN1 PVALB MACF1	3.95e-03	152	79	4	PF00036
Domain	ANK	ANKRD31 ANKS6 UACA ANKRD13C RIPK4	4.23e-03	251	79	5	SM00248
Domain	ANK_REPEAT	ANKRD31 ANKS6 UACA ANKRD13C RIPK4	4.38e-03	253	79	5	PS50088
Domain	ANK_REP_REGION	ANKRD31 ANKS6 UACA ANKRD13C RIPK4	4.45e-03	254	79	5	PS50297
Domain	Ankyrin_rpt	ANKRD31 ANKS6 UACA ANKRD13C RIPK4	5.07e-03	262	79	5	IPR002110
Domain	C2_dom	OSBPL6 PRKCD PLCG2 PTEN	5.17e-03	164	79	4	IPR000008
Domain	SH3_1	ARHGEF19 TRIO SPTAN1 PLCG2	5.17e-03	164	79	4	PF00018
Domain	EF-hand_7	SPTAN1 PVALB MACF1	5.61e-03	85	79	3	PF13499
Domain	EF-hand-dom_pair	EFHC2 SPTAN1 PVALB MACF1 PLCG2	7.39e-03	287	79	5	IPR011992
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX15 CDC37 SF3B3 KRT18 MICAL2 FDPS SPTAN1 INTS11 SUPT16H EPB41L5 MACF1 PRKCD ALYREF PLCG2 EXOC2 CBR1 DIS3 HNRNPU	2.53e-09	1353	83	18	29467282
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	DHX15 CDC37 NCAPD3 EMC3 SF3B3 KRT18 UACA FDPS SPTAN1 SUPT16H ALYREF MRPL45 EXOC2 DENND1A DIS3 HNRNPU SLC27A2 IWS1	6.66e-09	1440	83	18	30833792
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	DHX15 CCDC91 NCAPD3 SF3B3 SUPT16H FBRS MAP4K4 DIS3	1.36e-08	182	83	8	32239614
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX15 EMC3 SF3B3 OFD1 KRT18 MYO5B SUPT5H SUPT16H MACF1 ALYREF MAP4K4 CBR1 HNRNPU FAM83B ABCB1	1.84e-08	1024	83	15	24711643
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DHX15 CDC37 NCAPD3 SF3B3 ATR TRIO SUPT5H SPTAN1 INTS11 SUPT16H PRKCD ALYREF MAP4K4 CBR1 DIS3 HNRNPU SEPTIN2	3.70e-08	1425	83	17	30948266
Pubmed	Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.	DHX15 SF3B3 PTBP2 SUPT5H SPTAN1 SUPT16H	3.70e-07	116	83	6	37117180
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	EMC3 OFD1 KRT18 TRIO MYO5B SUPT5H SPTAN1 INTS11 SUPT16H PTEN CNTROB KNL1 IWS1	1.19e-06	1049	83	13	27880917
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX15 CDC37 SF3B3 KRT18 UACA MYO5B SYNM SPTAN1 SUPT16H ALYREF RSBN1L HNRNPU FAM83B SEPTIN2	1.56e-06	1257	83	14	36526897
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	DHX15 SNF8 CDC37 STRN3 RAP1GDS1 KRT18 SUPT5H FDPS SPTAN1 SUPT16H MACF1 DIS3 HNRNPU IWS1 SEPTIN2	1.64e-06	1455	83	15	22863883
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX15 SF3B3 PTBP2 SUPT5H SPTAN1 INTS11 SUPT16H MACF1 MRPL45 MAP4K4 HNRNPU DNMT3A IWS1	1.68e-06	1082	83	13	38697112
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RAP1GDS1 TRIO SYNM SUPT5H MICAL2 SPTAN1 OLFM1 MACF1 TAOK1 RIPK4 MAP4K4 CBR1 RSBN1L SEPTIN2	2.01e-06	1285	83	14	35914814
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	DHX15 CDC37 SPTAN1 ALYREF MAP4K4 HNRNPU	2.10e-06	156	83	6	22952844
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	EFHC2 TBC1D32 ANKS6 SF3B3 OFD1 MYO5B SUPT5H SUPT16H FBRS OSBPL6 ALYREF EXOC2 DENND1A DIS3	2.77e-06	1321	83	14	27173435
Pubmed	A protein interaction landscape of breast cancer.	CDC37 BRCA2 TRIO MYO5B SUPT5H MICAL2 SUPT16H MACF1 CBR1 FAM83B	2.78e-06	634	83	10	34591612
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	DHX15 SF3B3 SYNM PTBP2 SUPT5H ALYREF DIS3 HNRNPU IWS1 SEPTIN2	3.61e-06	653	83	10	33742100
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DHX15 KRT18 UACA SUPT5H SPTAN1 SUPT16H MACF1 ALYREF IWS1 SEPTIN2	3.96e-06	660	83	10	32780723
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	DHX15 CDC37 RAP1GDS1 SF3B3 KRT18 SUPT5H SUPT16H ALYREF CBR1 DIS3 HNRNPU KNL1 IWS1 SEPTIN2	4.11e-06	1367	83	14	32687490
Pubmed	Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.	ATR BRCA2 PVALB	4.68e-06	14	83	3	24899707
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	SNF8 VIL1 RAP1GDS1 UACA MYO5B SLC6A19 PRKCD ALYREF TAOK1 CBR1 SLC27A2 ABCB1	5.21e-06	1016	83	12	19056867
Pubmed	Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages.	PRKCD RIPK4	5.63e-06	2	83	2	18511573
Pubmed	Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.	PTEN DNMT3A	5.63e-06	2	83	2	20467490
Pubmed	Abrogation of ATR function preferentially augments cisplatin-induced cytotoxicity in PTEN-deficient breast cancer cells.	ATR PTEN	5.63e-06	2	83	2	37802411
Pubmed	Management of atypical pneumonias in view of the new entity "Legionnaire's disease".	KRT18 USH2A	5.63e-06	2	83	2	276901
Pubmed	FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.	FDPS PTEN	5.63e-06	2	83	2	30914801
Pubmed	Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy.	ATR PTEN	5.63e-06	2	83	2	29396668
Pubmed	DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis.	PRKCD RIPK4	5.63e-06	2	83	2	10948194
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	VIL1 STRN3 SF3B3 KRT18 MYO5B PTBP2 SPTAN1 SUPT16H TENM1 MACF1 C2orf78 HNRNPU CFAP46 ABCB1	7.56e-06	1442	83	14	35575683
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	DHX15 VIL1 SPTAN1 SUPT16H MACF1 ALYREF CBR1 HNRNPU SLC27A2 SEPTIN2	7.60e-06	711	83	10	33022573
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	DHX15 CDC37 SF3B3 KRT18 UACA MYO5B MICAL2 FDPS SPTAN1 ALYREF DIS3 HNRNPU FAM83B	7.82e-06	1247	83	13	27684187
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	UACA TRIO SPTAN1 OLFM1 MACF1	1.05e-05	120	83	5	31413325
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SF3B3 ATR PTBP2 SPTAN1 MACF1 TAOK1 EXOC2 HNRNPU KNL1	1.06e-05	582	83	9	20467437
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	DHX15 DNAH3 SF3B3 ATR SPTAN1 ALYREF HNRNPU	1.12e-05	317	83	7	17620599
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DHX15 NCAPD3 SF3B3 ATR KRT18 SUPT5H INTS11 SUPT16H ALYREF SLFN5 HNRNPU SLC27A2 IWS1	1.16e-05	1294	83	13	30804502
Pubmed	Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.	DHX15 STRN3 PTBP2 HNRNPU	1.33e-05	60	83	4	29055695
Pubmed	The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.	OFD1 KRT18 UACA MYO5B SPTAN1 ALYREF HNRNPU	1.40e-05	328	83	7	23398456
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	SF3B3 KRT18 SUPT5H SPTAN1 EXOC2 IWS1	1.47e-05	219	83	6	31353912
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	DHX15 SF3B3 KRT18 PTBP2 SPTAN1 ALYREF CBR1 HNRNPU	1.53e-05	463	83	8	34901782
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STRN3 NCAPD3 ATR UACA SPTAN1 PRKCD TAOK1 EXOC2 MAP4K4 IWS1	1.58e-05	774	83	10	15302935
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	DHX15 SPTAN1 SUPT16H HNRNPU	1.61e-05	63	83	4	37052853
Pubmed	Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.	BRCA2 CNTROB	1.69e-05	3	83	2	16275750
Pubmed	ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.	ATR PTEN	1.69e-05	3	83	2	28273450
Pubmed	Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.	BRCA2 PTEN	1.69e-05	3	83	2	17636424
Pubmed	Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.	PRKCD SLC27A2	1.69e-05	3	83	2	38743615
Pubmed	Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.	ATR BRCA2	1.69e-05	3	83	2	24672057
Pubmed	FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells.	PRKCD ABCB1	1.69e-05	3	83	2	24814288
Pubmed	Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.	BRCA2 PTEN	1.69e-05	3	83	2	25176644
Pubmed	A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer.	ROS1 GRIK2	1.69e-05	3	83	2	9021139
Pubmed	ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.	PTEN ABCB1	1.69e-05	3	83	2	24647572
Pubmed	Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes.	PVALB PTEN	1.69e-05	3	83	2	33504340
Pubmed	Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment.	BRCA2 PTEN	1.69e-05	3	83	2	31940494
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	DHX15 CDC37 STRN3 SF3B3 KRT18 SPTAN1 SUPT16H MACF1 ALYREF CBR1 HNRNPU SEPTIN2	1.78e-05	1149	83	12	35446349
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	STRN3 UACA TRIO SPTAN1 SUPT16H MACF1 ALYREF GRIK2 MAP4K4 HNRNPU SEPTIN2	1.82e-05	963	83	11	28671696
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SAMD9L LRRN1 UACA MYO5B SYNM EPB41L5 MACF1 TAOK1	2.40e-05	493	83	8	15368895
Pubmed	The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.	DHX15 CDC37 SF3B3 SPTAN1 ALYREF HNRNPU	2.40e-05	239	83	6	26641092
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	DHX15 CDC37 SF3B3 KRT18 SPTAN1 SUPT16H HNRNPU SEPTIN2	2.43e-05	494	83	8	26831064
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	DHX15 EMC3 SF3B3 KRT18 SPTAN1 SUPT16H MACF1 ALYREF EXOC2 CBR1 DIS3 HNRNPU IWS1	2.96e-05	1415	83	13	28515276
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DHX15 STRN3 RAP1GDS1 SF3B3 TRIO MYO5B MICAL2 SPTAN1 OSBPL6 MACF1 CBR1 HNRNPU SEPTIN2	3.32e-05	1431	83	13	37142655
Pubmed	Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer.	PTEN ABCB1	3.37e-05	4	83	2	20056007
Pubmed	Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population.	ATR BRCA2	3.37e-05	4	83	2	20513533
Pubmed	Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.	BRCA2 PTEN	3.37e-05	4	83	2	24615332
Pubmed	Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.	PLA2G7 ABCB1	3.37e-05	4	83	2	27641736
Pubmed	Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism.	KRT18 BCAT2	3.37e-05	4	83	2	28219950
Pubmed	Disruption of spectrin-like cytoskeleton in differentiating keratinocytes by PKCδ activation is associated with phosphorylated adducin.	SPTAN1 PRKCD	3.37e-05	4	83	2	22163289
Pubmed	Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts.	BRCA2 PTEN	3.37e-05	4	83	2	31806642
Pubmed	Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex.	PVALB PTEN	3.37e-05	4	83	2	27611660
Pubmed	ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.	ATR BRCA2	3.37e-05	4	83	2	23548269
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	OFD1 KRT18 TRIO SPTAN1 OSBPL6 EPB41L5 MACF1 MAP4K4 DENND1A FAM83B	3.91e-05	861	83	10	36931259
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SYNM TENM1 EPB41L5 MACF1 MAP4K4 FAM83B	4.10e-05	263	83	6	34702444
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	ALYREF MAP4K4 IWS1	4.11e-05	28	83	3	24462114
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CDC37 EMC3 SF3B3 OFD1 UACA SYNM SPTAN1 SUPT16H EPB41L5 MACF1 MRPL45 MAP4K4 FAM83B	4.93e-05	1487	83	13	33957083
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	DHX15 SF3B3 SPTAN1 ALYREF HNRNPU	5.46e-05	169	83	5	23084401
Pubmed	Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers.	ATR BRCA2	5.60e-05	5	83	2	18642075
Pubmed	A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.	PTEN DNMT3A	5.60e-05	5	83	2	23435381
Pubmed	Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis.	KRT18 PRKCD	5.60e-05	5	83	2	27422101
Pubmed	Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.	PTEN DNMT3A	5.60e-05	5	83	2	20889571
Pubmed	Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.	PRKCD PLCG2	5.60e-05	5	83	2	22806935
Pubmed	Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.	ALYREF IWS1	5.60e-05	5	83	2	30846735
Pubmed	Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.	BRCA2 PTEN	5.60e-05	5	83	2	24332043
Pubmed	FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.	SUPT5H SUPT16H	5.60e-05	5	83	2	10912001
Pubmed	Cdx2 regulates endo-lysosomal function and epithelial cell polarity.	VIL1 MYO5B SPTAN1	6.79e-05	33	83	3	20551175
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SF3B3 BRCA2 SUPT5H FBRS MACF1 DIS3 KNL1 FAM83B	8.25e-05	588	83	8	38580884
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STRN3 EMC3 TRIO FDPS SPTAN1 TENM1 OLFM1 MACF1 PTEN MAP4K4 HNRNPU	8.28e-05	1139	83	11	36417873
Pubmed	Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States.	PVALB DNMT3A	8.39e-05	6	83	2	29056337
Pubmed	High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.	BRCA2 PTEN	8.39e-05	6	83	2	28608929
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN5 SLFN14	8.39e-05	6	83	2	9846487
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	DHX15 SF3B3 BRCA2 KRT18 PTBP2 SUPT16H ALYREF RSBN1L HNRNPU KNL1	9.16e-05	954	83	10	36373674
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	SF3B3 UACA SUPT16H MACF1 ALYREF TAOK1 MAP4K4 DIS3	9.60e-05	601	83	8	33658012
Pubmed	ZNF212 promotes genomic integrity through direct interaction with TRAIP.	CDC37 KRT18 CNTROB	9.60e-05	37	83	3	36594163
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	KRT18 UACA SPTAN1 MACF1 SEPTIN2	9.73e-05	191	83	5	33762435
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	STRN3 OFD1 SPTAN1 MAP4K4 CNTROB DENND1A FAM83B	9.76e-05	446	83	7	24255178
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DHX15 VIL1 UACA SPTAN1 INTS11 SUPT16H EPB41L5 ALYREF TAOK1 ROS1 DENND1A RSBN1L	9.78e-05	1371	83	12	36244648
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	DHX15 SF3B3 SPTAN1 SUPT16H EPB41L5 ALYREF HNRNPU ABCB1	9.93e-05	604	83	8	37616343
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	DHX15 SF3B3 KRT18 SUPT5H SUPT16H ALYREF HNRNPU IWS1	1.00e-04	605	83	8	28977666
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	UACA EPB41L5 DENND1A KNL1	1.03e-04	101	83	4	10997877
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	TRIO GRIK2 SERPINA2 USH2A	1.03e-04	101	83	4	18519826
Pubmed	Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.	CDC37 STRN3 OFD1	1.04e-04	38	83	3	36674791
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	NCAPD3 UACA EPB41L5 EXOC2	1.16e-04	104	83	4	31240132
Pubmed	The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.	PVALB TENM1	1.17e-04	7	83	2	27720483
Pubmed	Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation.	PVALB PTEN	1.17e-04	7	83	2	38741709
Pubmed	The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.	ALYREF IWS1	1.17e-04	7	83	2	17234882
Interaction	BRCA1 interactions	DHX15 CDC37 NCAPD3 SF3B3 ATR BRCA2 KRT18 TRIO SUPT5H MICAL2 SPTAN1 SUPT16H ALYREF USH2A MAP4K4 CBR1 HNRNPU KNL1 SEPTIN2	5.61e-07	1249	83	19	int:BRCA1
Interaction	KDF1 interactions	DHX15 CCDC91 NCAPD3 SF3B3 SUPT16H FBRS MAP4K4 DIS3	1.26e-06	192	83	8	int:KDF1
Interaction	ECT2 interactions	DHX15 CCDC91 SF3B3 OFD1 MYO5B SPTAN1 SUPT16H EPB41L5 MACF1 ALYREF RIPK4 MRPL45 HNRNPU FAM83B SEPTIN2	2.96e-06	887	83	15	int:ECT2
Interaction	RHOB interactions	RAP1GDS1 UACA TRIO SPTAN1 SUPT16H OSBPL6 EPB41L5 MACF1 PRKCD EXOC2 MAP4K4 HNRNPU FAM83B SEPTIN2	7.81e-06	840	83	14	int:RHOB
Interaction	PLEC interactions	NCAPD3 DNAH3 ATR BRCA2 KRT18 SPTAN1 MACF1 CASQ2 PTEN DIS3	1.07e-05	430	83	10	int:PLEC
Interaction	EED interactions	DHX15 NCAPD3 SF3B3 KRT18 TRIO MYO5B SUPT5H SPTAN1 SUPT16H MACF1 ALYREF EXOC2 PSPH PTEN CBR1 DIS3 HNRNPU DNMT3A	1.91e-05	1445	83	18	int:EED
Interaction	RHOF interactions	NCAPD3 RAP1GDS1 EMC3 ATR UACA SPTAN1 SUPT16H EPB41L5 MACF1 MAP4K4 DIS3 FAM83B	1.93e-05	673	83	12	int:RHOF
Interaction	NELFE interactions	DHX15 SF3B3 PTBP2 SUPT5H SPTAN1 SUPT16H DIS3	1.93e-05	201	83	7	int:NELFE
Interaction	GSK3A interactions	DHX15 CDC37 SF3B3 OFD1 TRIO PTBP2 MACF1 PRKCD CNTROB HNRNPU	2.06e-05	464	83	10	int:GSK3A
Interaction	CDCA5 interactions	DHX15 CDC37 ARHGEF19 SF3B3 MYO5B SPTAN1	2.46e-05	140	83	6	int:CDCA5
Interaction	NEDD1 interactions	SF3B3 OFD1 CILP ALYREF PTEN CNTROB HNRNPU	3.55e-05	221	83	7	int:NEDD1
Interaction	CDC5L interactions	DHX15 SF3B3 ATR KRT18 TRIO PTBP2 SUPT5H SPTAN1 MACF1 ALYREF EXOC2 HNRNPU KNL1	4.45e-05	855	83	13	int:CDC5L
Interaction	KRT18 interactions	DHX15 OFD1 KRT18 FDPS USH2A CNTROB HNRNPU CFAP46 FAM83B	5.63e-05	419	83	9	int:KRT18
Interaction	YWHAB interactions	DHX15 CDC37 NCAPD3 KRT18 UACA SPTAN1 OSBPL6 EPB41L5 MACF1 PRKCD TAOK1 RIPK4 DENND1A FAM83B	6.27e-05	1014	83	14	int:YWHAB
Interaction	DISC1 interactions	CDC37 OFD1 TRIO SYNM SPTAN1 OLFM1 MACF1 ALYREF MAP4K4	6.74e-05	429	83	9	int:DISC1
Interaction	COPE interactions	EFHC2 CDC37 EMC3 SF3B3 MICAL2 SPTAN1 ROS1 SEPTIN2	7.01e-05	334	83	8	int:COPE
Interaction	CDKN2A interactions	EFHC2 CDC37 RAP1GDS1 ATR SUPT16H EXOC2 PTEN HNRNPU	7.16e-05	335	83	8	int:CDKN2A
Interaction	SNRPC interactions	SF3B3 OFD1 SUPT5H INTS11 SUPT16H MACF1 ALYREF HNRNPU IWS1	8.18e-05	440	83	9	int:SNRPC
Interaction	CDK2 interactions	DHX15 CDC37 RAP1GDS1 SF3B3 OFD1 ATR BRCA2 SPTAN1 SUPT16H ALYREF CNTROB HNRNPU	8.36e-05	783	83	12	int:CDK2
Interaction	PPP2R1A interactions	DHX15 CDC37 STRN3 NCAPD3 KRT18 SYNM SUPT5H FDPS INTS11 RIPK4 MAP4K4	8.67e-05	665	83	11	int:PPP2R1A
Interaction	EPYC interactions	EPYC PLCG2	1.00e-04	4	83	2	int:EPYC
Interaction	DIRAS3 interactions	CDC37 RAP1GDS1 SPTAN1 EPB41L5 MACF1 MAP4K4 FAM83B	1.04e-04	262	83	7	int:DIRAS3
Interaction	GRK5 interactions	DHX15 CDC37 SPTAN1 ALYREF MAP4K4 HNRNPU	1.06e-04	182	83	6	int:GRK5
Interaction	IWS1 interactions	DHX15 SUPT5H SUPT16H ALYREF IWS1	1.18e-04	116	83	5	int:IWS1
Interaction	H2BC21 interactions	DHX15 SUPT5H INTS11 SUPT16H OSBPL6 TENM1 CASQ2 MAP4K4 HNRNPU CFAP46 IWS1	1.30e-04	696	83	11	int:H2BC21
Interaction	PPP5C interactions	CDC37 RAP1GDS1 ATR RIPK4 PTEN DIS3 HNRNPU	1.31e-04	272	83	7	int:PPP5C
Interaction	YWHAH interactions	CDC37 OFD1 KRT18 UACA TRIO SPTAN1 OSBPL6 EPB41L5 MACF1 TAOK1 RIPK4 MAP4K4 DENND1A FAM83B	1.51e-04	1102	83	14	int:YWHAH
Interaction	YWHAG interactions	DHX15 CDC37 SF3B3 KRT18 UACA SPTAN1 OSBPL6 EPB41L5 MACF1 PRKCD TAOK1 RIPK4 MAP4K4 DENND1A FAM83B	1.57e-04	1248	83	15	int:YWHAG
Interaction	SNRPA interactions	DHX15 SF3B3 PTBP2 SUPT5H SUPT16H ALYREF PTEN HNRNPU IWS1	1.63e-04	482	83	9	int:SNRPA
Interaction	PPP2CA interactions	STRN3 NCAPD3 BRCA2 SUPT5H INTS11 EPB41L5 PRKCD PTEN MAP4K4	1.68e-04	484	83	9	int:PPP2CA
Interaction	CUL7 interactions	DHX15 CDC37 SF3B3 KRT18 SUPT5H SUPT16H MACF1 CASQ2 ALYREF CBR1 HNRNPU ABCB1	1.71e-04	845	83	12	int:CUL7
Interaction	SOX2 interactions	DHX15 PTBP2 SUPT5H SPTAN1 INTS11 SUPT16H FBRS MACF1 PRKCD ALYREF SLFN5 PSPH CBR1 HNRNPU KNL1 SEPTIN2	1.97e-04	1422	83	16	int:SOX2
Interaction	UHRF1 interactions	TBC1D32 ATR SUPT16H ALYREF HNRNPU DNMT3A	2.19e-04	208	83	6	int:UHRF1
Interaction	ACIN1 interactions	DHX15 BRCA2 SUPT5H SUPT16H ALYREF IWS1 SEPTIN2	2.43e-04	301	83	7	int:ACIN1
Interaction	EFTUD2 interactions	DHX15 SNF8 EMC3 SF3B3 KRT18 SUPT5H SPTAN1 SUPT16H MACF1 ALYREF EXOC2 PTEN CBR1 DIS3 HNRNPU IWS1	2.44e-04	1449	83	16	int:EFTUD2
Interaction	PLK1 interactions	NCAPD3 SF3B3 OFD1 BRCA2 INTS11 OSBPL6 PTEN CNTROB HNRNPU	2.48e-04	510	83	9	int:PLK1
Interaction	TRIM37 interactions	SF3B3 OFD1 KRT18 SYNM SPTAN1 MAGEB18 ALYREF PTEN CNTROB HNRNPU	2.59e-04	630	83	10	int:TRIM37
Interaction	CMTR1 interactions	DHX15 SF3B3 SUPT5H EPB41L5 ALYREF HNRNPU	2.82e-04	218	83	6	int:CMTR1
Interaction	EPB41L4A interactions	SPTAN1 EPB41L5 MACF1 MAP4K4 FAM83B	2.83e-04	140	83	5	int:EPB41L4A
Interaction	KIF23 interactions	DHX15 SF3B3 MYO5B MICAL2 SPTAN1 SUPT16H MACF1 ALYREF PTEN MAP4K4 HNRNPU SLC27A2 FAM83B	2.88e-04	1031	83	13	int:KIF23
Interaction	C11orf52 interactions	UACA TRIO SPTAN1 EPB41L5 MACF1 MAP4K4 FAM83B	2.97e-04	311	83	7	int:C11orf52
Interaction	EXOC1 interactions	STRN3 TRIO SPTAN1 MACF1 EXOC2	3.12e-04	143	83	5	int:EXOC1
Interaction	BIRC3 interactions	DHX15 CDC37 SF3B3 ATR TRIO SUPT5H SPTAN1 SUPT16H PRKCD ALYREF RIPK4 CBR1 DIS3 HNRNPU SEPTIN2	3.24e-04	1334	83	15	int:BIRC3
Interaction	NAA16 interactions	ALYREF RIPK4 HNRNPU	3.36e-04	33	83	3	int:NAA16
Interaction	EME2 interactions	BRCA2 PTEN	3.47e-04	7	83	2	int:EME2
Interaction	KIF20A interactions	DHX15 SAMD9L SF3B3 UACA PTBP2 SPTAN1 SUPT16H MACF1 ALYREF PLCG2 MAP4K4 HNRNPU FAM83B	3.50e-04	1052	83	13	int:KIF20A
Interaction	POLR2A interactions	BRCA2 SUPT5H INTS11 SUPT16H ALYREF PTEN HNRNPU DNMT3A IWS1	3.57e-04	536	83	9	int:POLR2A
Interaction	HDGF interactions	DHX15 KRT18 SUPT16H ALYREF RIPK4 PTEN HNRNPU	3.59e-04	321	83	7	int:HDGF
Interaction	SLMAP interactions	STRN3 OFD1 MAP4K4 CNTROB FAM83B	3.77e-04	149	83	5	int:SLMAP
Interaction	HSPA4 interactions	CDC37 OFD1 ATR BRCA2 KRT18 TRIO PRKCD RIPK4 PTEN KNL1	4.07e-04	667	83	10	int:HSPA4
Interaction	AKT3 interactions	CDC37 PRKCD MAP4K4 IWS1	4.20e-04	85	83	4	int:AKT3
Interaction	TPBG interactions	SF3B3 HNRNPU SEPTIN2	4.36e-04	36	83	3	int:TPBG
GeneFamily	Schlafen family	SLFN5 SLFN14	2.25e-04	7	60	2	1110
GeneFamily	Ankyrin repeat domain containing	ANKRD31 ANKS6 UACA ANKRD13C RIPK4	1.24e-03	242	60	5	403
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_top-relative-expression-ranked_1000	NCAPD3 KRT18 TRIO MYO5B TENM1 EPB41L5 ROS1 GRIK2 RIPK4 PSPH PTEN SLC27A2 DNMT3A	1.14e-05	801	82	13	gudmap_developingKidney_e15.5_ureter tip_1000_flank cortic collct
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#5	BRCA2 MYO5B SUPT16H EPB41L5 TAOK1 HNRNPU IWS1	1.41e-05	204	82	7	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	BRCA2 ANKRD13C MYO5B PTBP2 SPTAN1 SUPT16H EPB41L5 TAOK1 HNRNPU IWS1	3.80e-05	532	82	10	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	BRCA2 PTBP2 SUPT16H HNRNPU KNL1 IWS1	1.00e-04	192	82	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	LRRN1 BRCA2 PTBP2 SUPT16H EPB41L5 GRIK2 HNRNPU KNL1 IWS1	1.28e-04	498	82	9	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#2_top-relative-expression-ranked_500	OFD1 ATR BRCA2 SLC27A2	1.39e-04	68	82	4	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k2_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	LRRN1 PTBP2 SUPT16H EPB41L5 TAOK1 HNRNPU IWS1	1.55e-04	298	82	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K4
CoexpressionAtlas	DevelopingKidney_e11.5_ureteric bud_emap-3844_top-relative-expression-ranked_500	MYO5B TENM1 EPB41L5 ROS1 GRIK2 PSPH SLC27A2 DNMT3A	1.59e-04	401	82	8	gudmap_developingKidney_e11.5_ureteric bud_500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#4_top-relative-expression-ranked_1000	OFD1 ATR BRCA2 SLC27A2	1.74e-04	72	82	4	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k4_1000
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	SAMD9L SPTAN1 TENM1 MACF1 SLFN5 SLC27A2	1.97e-06	199	83	6	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	DNAH3 CILP EPYC ROS1 GRIK2	1.17e-05	158	83	5	ab05f6d7968ccd6d3826cd71b763dbedc83822c3
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 KRT18 MYO5B RIPK4 SLC27A2	1.86e-05	174	83	5	e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 KRT18 MYO5B RIPK4 SLC27A2	1.86e-05	174	83	5	ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLA2G7 LRRN1 KRT18 CASQ2 SLC27A2	2.69e-05	188	83	5	340f0e3e65c7a00d82d26621ff37107458bebc41
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLA2G7 LRRN1 KRT18 CASQ2 SLC27A2	2.69e-05	188	83	5	9d384c0934f1461bc37b1f83e0877d7bee2116ee
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFHC2 DNAH3 OSBPL6 SLC27A2 CFAP46	3.05e-05	193	83	5	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARHGEF19 KRT18 MYO5B RIPK4 SLC27A2	3.05e-05	193	83	5	979980369d2dbee9dc4770d72b93037abd7786eb
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-NK_CD56bright_CD16-\|bone_marrow / Manually curated celltypes from each tissue	RAP1GDS1 OFD1 MICAL2 PLCG2 ABCB1	3.13e-05	194	83	5	5c58a2d1dd3c8ff77ce44d473239685e6b020909
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KRT18 MYO5B MICAL2 ROS1 RIPK4	3.13e-05	194	83	5	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-K_(Pericytes)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	DHX15 KRT18 SYNM BCAT2 CASQ2	3.29e-05	196	83	5	541b1fcf509e362f6f48720046cb5378aaf7c591
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 KRT18 MYO5B SPTAN1 CBR1	3.37e-05	197	83	5	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX15 TAOK1 RIPK4 MAP4K4 FAM83B	3.45e-05	198	83	5	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX15 TAOK1 RIPK4 MAP4K4 FAM83B	3.45e-05	198	83	5	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	BAL-Severe\|BAL / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLA2G7 SAMD9L MACF1 TAOK1 SLFN5	3.45e-05	198	83	5	454aee3f4fe6d0beeccc55200b4495f4f9b44feb
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CCDC91 UACA MRPL45 SLFN5 SLC27A2	3.53e-05	199	83	5	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX15 SF3B3 TAOK1 MAP4K4 HNRNPU	3.53e-05	199	83	5	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-Treg\|Leuk-UTI / Disease, condition lineage and cell class	ANKRD31 SPTAN1 OSBPL6 SLFN5 FAM118A	3.53e-05	199	83	5	100f45e04f284551b29ef0406476bdc347ddbf7e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 KRT18 SLC6A19 CBR1 ABCB1	3.53e-05	199	83	5	0181c13379f869be47804cdb11bbdabcd30b9b23
ToppCell	COVID-19_Severe-immature_Neutrophil\|COVID-19_Severe / Disease condition and Cell class	LRRN1 BRCA2 PLCG2 SLC27A2 KNL1	3.53e-05	199	83	5	f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCell	COVID-19_Severe-immature_Neutrophil-\|COVID-19_Severe / Disease condition and Cell class	LRRN1 BRCA2 PLCG2 SLC27A2 KNL1	3.53e-05	199	83	5	42ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 KRT18 SLC6A19 CBR1 ABCB1	3.53e-05	199	83	5	ee981046217e8759610eb58a670d98f32cd83abc
ToppCell	Control_saline-Endothelial-Endothelial-FOXM1\|Control_saline / Treatment groups by lineage, cell group, cell type	NCAPD3 BRCA2 OLFM1 CNTROB KNL1	3.62e-05	200	83	5	9bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L MACF1 PLCG2 SLFN5 HNRNPU	3.62e-05	200	83	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EFHC2 DNAH3 OSBPL6 SLC27A2 CFAP46	3.62e-05	200	83	5	ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NCAPD3 BRCA2 SUPT16H SLC27A2 KNL1	3.62e-05	200	83	5	7e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Ciliated\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	EFHC2 DNAH3 OSBPL6 SLC27A2 CFAP46	3.62e-05	200	83	5	a521cf837cadf280505ff9d7e641a205af7d6513
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EFHC2 DNAH3 OSBPL6 SLC27A2 CFAP46	3.62e-05	200	83	5	918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NCAPD3 BRCA2 SUPT16H SLC27A2 KNL1	3.62e-05	200	83	5	9775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Car3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SAMD9L SYNM PRKCD ROS1	1.15e-04	134	83	4	4ef5f395e321cf04e56560be2502a8aa157682f4
ToppCell	Leuk-UTI-Lymphocyte-T_NK-Treg\|Leuk-UTI / Disease, Lineage and Cell Type	ANKRD31 SPTAN1 OSBPL6 SLFN5	1.92e-04	153	83	4	b24c693b142206d13b29c96faa7f79a1a22bc2ef
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 PRKCD PLCG2 SLFN5	2.56e-04	165	83	4	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 PRKCD PLCG2 SLFN5	2.56e-04	165	83	4	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	5'-Adult-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANKS6 KRT18 FDPS PRKCD	2.62e-04	166	83	4	0b4e1d879c61be9d18d7aac51e5115f103f51209
ToppCell	Control\|World / group, cell type (main and fine annotations)	MYO5B MICAL2 EPB41L5 ROS1	2.74e-04	168	83	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 PRKCD PLCG2 SLFN5	3.00e-04	172	83	4	b26fc612f232e8e273825ac2d2e5519cbb7322cf
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	EMC3 MICAL2 SLC6A19 SLFN14	3.00e-04	172	83	4	f0b658baa4b41329c95a09387cc55ea046e2333f
ToppCell	control-Lymphocytic-CD4_T_cells_3\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HTR2B SPTAN1 SLFN5 SLFN14	3.06e-04	173	83	4	0c9fb18536ddd61b51b7bb4d40841f67b017f360
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT18 PVALB TENM1 RSBN1L	3.20e-04	175	83	4	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLA2G7 LRRN1 KRT18 SLC27A2	3.41e-04	178	83	4	3d120458a0a56097532ebfa5fc6f77b52af2af2a
ToppCell	Globus_pallidus-Macroglia\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ARHGEF19 EMC3 PSPH MAP4K4	3.48e-04	179	83	4	ab50f711b004b96107f813c9a2526ec21d1c8027
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	KRT18 MYO5B MICAL2 EPB41L5	3.48e-04	179	83	4	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYO5B TENM1 SLC27A2 ABCB1	3.56e-04	180	83	4	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	droplet-Marrow-BM-1m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UACA PRKCD PLCG2 SLFN5	3.63e-04	181	83	4	89c551de26de047c316c91ac1d97bdf728a33d9e
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC6A19 TENM1 SLC27A2 ABCB1	3.63e-04	181	83	4	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 BRCA2 GRIK2 KNL1	3.71e-04	182	83	4	336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SAMD9L UACA MAGEB18 ABCB1	3.79e-04	183	83	4	6cdadb3ece45a94a2915063aa461048e1d371ccd
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KRT18 MYO5B MICAL2 EPB41L5	3.79e-04	183	83	4	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 UACA EPB41L5 GRIK2	3.79e-04	183	83	4	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SAMD9L TRIO TAOK1 SLFN5	3.79e-04	183	83	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 UACA EPB41L5 GRIK2	3.79e-04	183	83	4	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo\|bone_marrow / Manually curated celltypes from each tissue	OFD1 SYNM FAM118A ABCB1	3.79e-04	183	83	4	2fb78622adc170dd3301e251418337523de50faf
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SAMD9L UACA MAGEB18 ABCB1	3.79e-04	183	83	4	8714d3e7663c93cdf9b25b647353572e136f30c3
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT18 OSBPL6 RIPK4 FAM83B	3.79e-04	183	83	4	ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid-Endo\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SAMD9L UACA MAGEB18 ABCB1	3.79e-04	183	83	4	c7fc96ac1d5d31ccefe0c1fc6ec76c7d8607a172
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM\|bone_marrow / Manually curated celltypes from each tissue	OFD1 SYNM FAM118A ABCB1	3.79e-04	183	83	4	37db007cc65005bffc18a5fda7f454a57c9fb0a9
ToppCell	facs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT18 OSBPL6 RIPK4 FAM83B	3.79e-04	183	83	4	f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCell	(7)_Epithelial-H_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	KRT18 BCAT2 RIPK4 FAM83B	3.87e-04	184	83	4	1f76b37c265b519171b767a52d48f31f0cdc4a3c
ToppCell	E12.5-Epithelial-airway_epithelial_cell-club_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARHGEF19 KRT18 MICAL2 RIPK4	3.87e-04	184	83	4	a69c3c57cd939b2888f548a0fbca3392ad310445
ToppCell	E12.5-Epithelial-airway_epithelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARHGEF19 KRT18 MICAL2 RIPK4	3.87e-04	184	83	4	3df78b17098b50e1a7f2c8791bf2d0806328330a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAP1GDS1 MYO5B MICAL2 ROS1	3.87e-04	184	83	4	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 UACA EPB41L5 GRIK2	3.87e-04	184	83	4	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 UACA EPB41L5 GRIK2	3.95e-04	185	83	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NCAPD3 BRCA2 SLC27A2 KNL1	3.95e-04	185	83	4	9d424a8608b339dd6129c58d87626678d4ec4af7
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	KRT18 MYO5B EPB41L5 ROS1	4.03e-04	186	83	4	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MYO5B MICAL2 ROS1 SLC27A2	4.03e-04	186	83	4	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	KRT18 MYO5B EPB41L5 ROS1	4.03e-04	186	83	4	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LRRN1 KRT18 MYO5B RIPK4	4.11e-04	187	83	4	c2940aec30b3c2c113f6a65126dc6f1969cf301e
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SAMD9L UACA SLFN5 ABCB1	4.11e-04	187	83	4	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|IPF / Disease state, Lineage and Cell class	LRRN1 KRT18 MYO5B ROS1	4.11e-04	187	83	4	19d6a404fc3651d98a93e3848e372df51a239c57
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L MACF1 PRKCD PLCG2	4.11e-04	187	83	4	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 BRCA2 GRIK2 KNL1	4.11e-04	187	83	4	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 KRT18 MYO5B SLC27A2	4.19e-04	188	83	4	d00f48afed62fc60d3530bb3b80ac0162b0b0ed8
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 ANKRD13C SLC6A19 SLC27A2	4.19e-04	188	83	4	b483b4629695764568bcbd1d527d614824147783
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	MYO5B MICAL2 EPB41L5 ROS1	4.19e-04	188	83	4	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RAP1GDS1 KRT18 MYO5B MICAL2	4.19e-04	188	83	4	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 ANKRD13C SLC6A19 SLC27A2	4.19e-04	188	83	4	c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	MYO5B MICAL2 EPB41L5 ROS1	4.19e-04	188	83	4	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPTAN1 TENM1 SLFN5 FAM118A	4.28e-04	189	83	4	9ab77c6fcb573854da5922412f53d2168bda6b58
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARHGEF19 MYO5B RIPK4 SLC27A2	4.28e-04	189	83	4	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	PND10-Epithelial-Epithelial_Airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KRT18 OSBPL6 CFAP46	4.28e-04	189	83	4	407d8a59969d83f014600aae1a55092283a13970
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|World / Disease state, Lineage and Cell class	LRRN1 KRT18 MYO5B ROS1	4.28e-04	189	83	4	8030a353473da34ae92429f2d822171a2e94248f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPTAN1 TENM1 SLFN5 FAM118A	4.28e-04	189	83	4	5a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCell	(2)_NK/T-(210)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	SAMD9L OLFM1 MACF1 ABCB1	4.28e-04	189	83	4	fa72e87e1e8cd7cbddae7b47e19cf90d181820a7
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCAPD3 BRCA2 OLFM1 KNL1	4.28e-04	189	83	4	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	(2)_NK/T-(21)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	SAMD9L OLFM1 MACF1 ABCB1	4.28e-04	189	83	4	b37ad24898a14a4a3b2d6cea2637de2471f76e20
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	NCAPD3 BRCA2 SUPT16H KNL1	4.36e-04	190	83	4	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KRT18 MYO5B MICAL2 EPB41L5	4.36e-04	190	83	4	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTAN1 MACF1 MAP4K4 HNRNPU	4.36e-04	190	83	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ARHGEF19 LRRN1 KRT18 ALYREF	4.36e-04	190	83	4	9f5f65869dad9a43ac94f81f9a19c72ffe5adc3c
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EFHC2 MACF1 SLFN5 ABCB1	4.45e-04	191	83	4	f1935e8f8467a2bc30588b7f2cc3b94e9c83b268
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EFHC2 MACF1 SLFN5 ABCB1	4.45e-04	191	83	4	1161e465c50c2071764279e01cf08b1048cce0e3
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT18 MYO5B OSBPL6 EPB41L5	4.45e-04	191	83	4	ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT18 MYO5B OSBPL6 EPB41L5	4.45e-04	191	83	4	c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EFHC2 MACF1 SLFN5 ABCB1	4.45e-04	191	83	4	7a4fe96989f72159385270c712342ba3e1ca6fc3
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BRCA2 PSPH KNL1 SEPTIN2	4.45e-04	191	83	4	588015d76b68488da6aa6603777682f3d81592bf
ToppCell	Control-Lymphoid_T/NK-NK_CD56bright\|Control / Disease group, lineage and cell class	EFHC2 MACF1 SLFN5 ABCB1	4.45e-04	191	83	4	e842f29bc03ed6734b2a7b975e7830a498f2743c
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EFHC2 MACF1 SLFN5 ABCB1	4.45e-04	191	83	4	c023ca893ceae19b54967096f6e2588dc39fa268
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNM SPTAN1 TENM1 SLC27A2	4.45e-04	191	83	4	4a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCell	(210)_NKT_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	SAMD9L MACF1 SLFN5 ABCB1	4.54e-04	192	83	4	08dc0c019c594da7b9944db8fd706aa7780e6ae9
Computational	Genes upregulated in subsets of cells of a given type within various tumors	TRIO MACF1 MAP4K4 HNRNPU	1.19e-04	50	55	4	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Computational	Genes in the cancer module 417.	PLA2G7 PLCG2 SLC27A2	1.82e-04	22	55	3	MODULE_417
Disease	Squamous cell carcinoma of oropharynx	ATR PTEN	4.67e-05	4	83	2	C0280313
Disease	aspartate aminotransferase to alanine aminotransferase ratio	DHX15 ANKRD31 SF3B3 BCAT2 SERPINA2 ABCB1	5.95e-05	239	83	6	EFO_0010934
Disease	Neoplasm of uncertain or unknown behavior of ovary	ATR BRCA2 PTEN	7.44e-05	29	83	3	C0496920
Disease	Ovarian Carcinoma	ATR BRCA2 PTEN	8.25e-05	30	83	3	C0029925
Disease	Glioma	ATR BRCA2 ROS1 PTEN	1.08e-04	87	83	4	C0017638
Disease	endometrial cancer (implicated_via_orthology)	ATR PTEN	2.16e-04	8	83	2	DOID:1380 (implicated_via_orthology)
Disease	serum albumin measurement	ARHGEF19 EPB41L5 MACF1 GRIK2 EXOC2 SERPINA2 RSBN1L SEPTIN2	2.64e-04	592	83	8	EFO_0004535
Disease	Intellectual Disability	TRIO SUPT16H MACF1 TAOK1 PTEN HNRNPU DNMT3A	2.69e-04	447	83	7	C3714756
Disease	Malignant tumor of prostate	BRCA2 PTEN	2.78e-04	9	83	2	cv:C0376358
Disease	Malignant neoplasm of kidney	BRCA2 PTEN ABCB1	2.80e-04	45	83	3	C0740457
Disease	hepatocellular carcinoma (implicated_via_orthology)	KRT18 UACA PTEN	3.60e-04	49	83	3	DOID:684 (implicated_via_orthology)
Disease	neuritic plaque measurement	TRIO OSBPL6 EPB41L5 CDYL2 GRIK2 PLCG2	4.60e-04	349	83	6	EFO_0006798
Disease	ossification of the posterior longitudinal ligament of the spine	CCDC91 DNMT3A	5.07e-04	12	83	2	EFO_0005895
Disease	ovarian neoplasm	ATR BRCA2 GRIK2 PTEN	5.66e-04	134	83	4	C0919267
Disease	Malignant neoplasm of ovary	ATR BRCA2 GRIK2 PTEN	6.15e-04	137	83	4	C1140680
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRCA2 PTEN	6.96e-04	14	83	2	C0677776
Disease	Malignant neoplasm of liver	KRT18 TRIO MYO5B GRIK2	7.04e-04	142	83	4	C0345904
Disease	Liver neoplasms	KRT18 TRIO MYO5B GRIK2	7.04e-04	142	83	4	C0023903
Disease	hyperinsulinism (biomarker_via_orthology)	PRKCD PTEN	8.02e-04	15	83	2	DOID:2018 (biomarker_via_orthology)
Disease	primary autosomal recessive microcephaly (is_implicated_in)	NCAPD3 KNL1	9.14e-04	16	83	2	DOID:0070296 (is_implicated_in)
Disease	breast size	CCDC91 OSBPL6 SERPINA2	9.84e-04	69	83	3	EFO_0004884
Disease	Non-Small Cell Lung Carcinoma	ROS1 GRIK2 PTEN ABCB1	9.99e-04	156	83	4	C0007131
Disease	colorectal cancer (is_marker_for)	BRCA2 PTEN MAP4K4 HNRNPU	1.02e-03	157	83	4	DOID:9256 (is_marker_for)
Disease	Malignant Glioma	BRCA2 ROS1 PTEN	1.03e-03	70	83	3	C0555198
Disease	mixed gliomas	BRCA2 ROS1 PTEN	1.03e-03	70	83	3	C0259783
Disease	Inborn Errors of Metabolism	PLA2G7 MYO5B	1.03e-03	17	83	2	C0025521
Disease	Malignant neoplasm of endometrium	ATR PTEN	1.16e-03	18	83	2	C0007103
Disease	Carcinoma in situ of endometrium	ATR PTEN	1.16e-03	18	83	2	C0346191
Disease	Adenocarcinoma of prostate	BRCA2 PTEN	1.44e-03	20	83	2	C0007112
Disease	left atrial function	CILP CASQ2	1.59e-03	21	83	2	EFO_0004294
Disease	Seckel syndrome	ATR DNMT3A	1.74e-03	22	83	2	C0265202
Disease	Autosomal Recessive Primary Microcephaly	NCAPD3 KNL1	1.74e-03	22	83	2	C3711387
Disease	Carcinoma of lung	BRCA2 PTEN	1.90e-03	23	83	2	C0684249
Disease	Neoplasm of the genitourinary tract	BRCA2 PTEN	2.07e-03	24	83	2	cv:C0042065
Disease	breast cancer (implicated_via_orthology)	ATR BRCA2	2.25e-03	25	83	2	DOID:1612 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	TRIO PTEN HNRNPU	2.32e-03	93	83	3	C1535926
Disease	non-alcoholic fatty liver disease (is_marker_for)	PLA2G7 KRT18	2.62e-03	27	83	2	DOID:0080208 (is_marker_for)
Disease	Malignant tumor of breast	BRCA2 PTEN	2.62e-03	27	83	2	cv:C0006142
Disease	Breast neoplasm	BRCA2 PTEN	2.62e-03	27	83	2	cv:C1458155
Disease	Sezary Syndrome	PTEN DNMT3A	2.62e-03	27	83	2	C0036920
Disease	Familial cancer of breast	BRCA2 PTEN	2.62e-03	27	83	2	cv:C0346153

Protein segments in the cluster

Peptide	Gene	Start	Entry
KMIRKGVFKDQHFDQ	PRPF4B	911	Q13523
MAENSKFFKKHGIRN	HTR2B	421	P41595
VFHALGKKIDMKTGF	C2orf78	636	A6NCI8
KQGKDQHFPVFMNEK	DNMT3A	841	Q9Y6K1
IMLGDKEKTFQFLHQ	TBC1D32	1076	Q96NH3
FKHFNKLREFVQMKL	ANKRD13C	476	Q8N6S4
FKHMVIVKAKLGQNF	CFAP46	1151	Q8IYW2
AKKAADEAKMRFAHI	DHX15	606	O43143
NIKRGKHMDFLSDFE	IWS1	516	Q96ST2
SDKENQKGFLMHFLK	OFD1	131	O75665
NHDELMKEKGIYFKL	ABCB1	611	P08183
ELGKFAVFVHAKMAE	ARHGEF19	636	Q8IW93
IDGKEKNMHSARFKN	ANKRD31	441	Q8N7Z5
HKFMAFKSFGELVHK	MAP4K4	1056	O95819
LFMKKNHEEEVKGLQ	KRT18	211	P05783
GDMIKFVIRKDKCHF	MAGEB18	131	Q96M61
LLVHGEAKKMEFLKQ	INTS11	411	Q5TA45
HIKIADFGMCKENIF	PRKCD	486	Q05655
HANAKKILLEMGEFF	FDPS	291	P14324
AKFHGKMEQKFLLVD	FAM83B	221	Q5T0W9
DMDFLIALAHEKFKK	EFHC2	616	Q5JST6
IALAHEKFKKNMFEN	EFHC2	621	Q5JST6
KGIKQEAFKDMYDLH	EPYC	226	Q99645
KSKFSQKDLEMLFHG	EXOC2	141	Q96KP1
HLARQFKAIKAKMDE	OLFM1	146	Q99784
KDLPEHAVLKMKGNF	HNRNPU	626	Q00839
NLMDAHKVFQKELGK	MACF1	2826	O94854
IKFHSAAMDEKVIGK	KNL1	1271	Q8NG31
KFLKDKFVEIGAHKD	PLCG2	181	P16885
HMAKAFKEVFGDLLL	PLCG2	416	P16885
MEENNLEHIPKFFKK	OSBPL6	886	Q9BZF3
MDAHKVFQKELGKRT	MACF1	6701	Q9UPN3
HGKPVKNALDLKFDM	PLA2G7	241	Q13093
FFKHQADMLLHGIKV	FAM118A	271	Q9NWS6
KDKFKAERIMVEGFH	SERPINA2	221	P20848
AIHMKKSLEKFVGDA	ATR	2201	Q13535
THFKMLKKLVEEATF	ATR	2241	Q13535
KKAKGQELFDQIMYH	EPB41L5	61	Q9HCM4
QEKMKGDSHKLDFRN	FBRS	101	Q9HAH7
EHNIKKSKMFFKDIE	BRCA2	1021	P51587
VSLFMIHKDGNDFKE	DNAH3	461	Q8TD57
SLMEKHNVLEKGFLK	CCDC91	161	Q7Z6B0
FVEKYEKQIKHFGML	CDC37	151	Q16543
KDHLKKFNELMVTFR	COQ7	91	Q99807
LFKKQIEHDKREMIF	RAP1GDS1	231	P52306
IFHALKMGNFQLVKE	ANKS6	296	Q68DC2
LMNKFVEDTKKGVHQ	CBR1	171	P16152
YKFAKDHAKMGIKEV	DENND1A	431	Q8TEH3
HKAIGFVMVDAKKEA	CASQ2	86	O14958
LMAKDLHFEGMFKKE	EMC3	241	Q9P0I2
KEMKRGKEFHVIFDC	GRIK2	216	Q13002
LFEGMKAFKGKDQQV	BCAT2	101	O15382
NLKKKDGSKHIFEME	CNTROB	86	Q8N137
HKIQEGDFKNMLRLK	LRRN1	276	Q6UXK5
KNIKEKAAHLASMFG	MICAL2	866	O94851
GDIKVEFFHKQNKML	PTEN	251	P60484
MDGKNVKAKLDHVQF	RSBN1L	781	Q6PCB5
QKGFVGCLKDVHFMK	USH2A	1666	O75445
EDRHIKFFDNKTGKM	STRN3	701	Q13033
VDRFNKDIEFMIGHK	SLC6A19	511	Q695T7
KTFMQGEFLKIKHIV	SLFN14	646	P0C7P3
TVKAFKFFQDHKMAL	PTBP2	481	Q9UKA9
HREQGKEQAMFDKKV	SYNM	1516	O15061
KTEKEFMQHARKAGL	MRPL45	51	Q9BRJ2
SKAAFIDHFNVMIKK	SAMD9L	256	Q8IVG5
MKENHEFDGKKLFQH	SLC27A2	531	O14975
KMKKLLFQEAHNGPA	TAOK1	311	Q7L7X3
NFAAEMEKLIKKHQA	TAOK1	506	Q7L7X3
QFDFVKLMDGKQLVK	TENM1	456	Q9UKZ4
QELRKYFKMGDHVKV	SUPT5H	466	O00267
EMRHKLKTAFKNFIE	SUPT16H	771	Q9Y5B9
KPFADEKNILHIMVK	RIPK4	221	P57078
FHVFDKVKVKIMLDS	DIS3	901	Q9Y2L1
DMFKTNLEEFASKHK	SNF8	41	Q96H20
FIDEFNGLHMSKDKR	CDYL2	51	Q8N8U2
PFNKKGSAVFHEIKM	CILP	556	O75339
QKFLKHKFLVQEIMF	NCAPD3	436	P42695
QEKKGAMSHALNFIK	VIL1	306	P09327
KEKFHFKKIIMIGDG	PSPH	166	P78330
MFKHFDKDKSGRLNH	SPTAN1	2331	Q13813
KVFHMLDKDKSGFIE	PVALB	46	P20472
KIEFLKEAHLMSKFN	ROS1	1991	P08922
KNMFEKIHQETFGKS	SF3B3	96	Q15393
GKVKQMQTHFLALKE	UACA	511	Q9BZF9
KPLDVAFMKAIHNKV	SEPTIN2	161	Q15019
LDKMQKENHFLIFVK	SLFN5	86	Q08AF3
DDMKGKDKIVFGNIH	TRIO	2006	O75962
VHFERKADALKAMKQ	ALYREF	151	Q86V81
GIKKVLKKHNDDFEM	MYO5B	1531	Q9ULV0