Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	quaternary ammonium group transmembrane transporter activity	SLC22A2 SLC22A4 SLC22A5	4.85e-05	15	97	3	GO:0015651
GeneOntologyMolecularFunction	neurotransmitter transmembrane transporter activity	SLC6A3 SLC22A2 SLC22A4	1.39e-04	21	97	3	GO:0005326
GeneOntologyMolecularFunction	acetate ester transmembrane transporter activity	SLC22A2 SLC22A4	1.39e-04	4	97	2	GO:1901375
GeneOntologyMolecularFunction	amino-acid betaine transmembrane transporter activity	SLC22A4 SLC22A5	1.39e-04	4	97	2	GO:0015199
GeneOntologyMolecularFunction	acetylcholine transmembrane transporter activity	SLC22A2 SLC22A4	1.39e-04	4	97	2	GO:0005277
GeneOntologyMolecularFunction	carnitine transmembrane transporter activity	SLC22A4 SLC22A5	3.46e-04	6	97	2	GO:0015226
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC6A3 SLC22A2 SLC22A4 SLC22A5	7.17e-04	83	97	4	GO:0015101
Domain	LIM3_prickle	PRICKLE1 PRICKLE3 PRICKLE2	1.20e-07	3	93	3	IPR033727
Domain	LIM2_prickle	PRICKLE1 PRICKLE3 PRICKLE2	1.20e-07	3	93	3	IPR033726
Domain	PET_prickle	PRICKLE1 PRICKLE3 PRICKLE2	1.20e-07	3	93	3	IPR033723
Domain	PET	PRICKLE1 PRICKLE3 PRICKLE2	2.36e-06	6	93	3	PF06297
Domain	PET_domain	PRICKLE1 PRICKLE3 PRICKLE2	2.36e-06	6	93	3	IPR010442
Domain	PET	PRICKLE1 PRICKLE3 PRICKLE2	2.36e-06	6	93	3	PS51303
Domain	Orgcat_transp/SVOP	SLC22A2 SLC22A4 SLC22A5	9.82e-06	9	93	3	IPR004749
Domain	Gal_Oxase/kelch_b-propeller	RAG2 LZTR1 KLHL11 KLHL12 KLHL8	1.11e-05	59	93	5	IPR011043
Domain	LIM1_prickle	PRICKLE3 PRICKLE2	2.45e-05	2	93	2	IPR033725
Domain	MFS_sugar_transport-like	SLC22A11 SLC22A2 SLC22A4 SLC22A5	3.00e-05	36	93	4	IPR005828
Domain	Sugar_tr	SLC22A11 SLC22A2 SLC22A4 SLC22A5	3.00e-05	36	93	4	PF00083
Domain	Kelch	LZTR1 KLHL11 KLHL12 KLHL8	1.99e-04	58	93	4	SM00612
Domain	SUGAR_TRANSPORT_1	SLC22A2 SLC22A4 SLC22A5	2.24e-04	24	93	3	PS00216
Domain	LIM	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	3.89e-04	69	93	4	PF00412
Domain	-	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	4.11e-04	70	93	4	2.10.110.10
Domain	Kelch_1	LZTR1 KLHL11 KLHL12 KLHL8	4.11e-04	70	93	4	PF01344
Domain	Kelch_1	LZTR1 KLHL11 KLHL12 KLHL8	4.11e-04	70	93	4	IPR006652
Domain	Znf_LIM	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	4.34e-04	71	93	4	IPR001781
Domain	LIM_DOMAIN_1	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	4.34e-04	71	93	4	PS00478
Domain	LIM_DOMAIN_2	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	4.34e-04	71	93	4	PS50023
Domain	LIM	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	4.34e-04	71	93	4	SM00132
Domain	Sugar_transporter_CS	SLC22A2 SLC22A4 SLC22A5	5.34e-04	32	93	3	IPR005829
Domain	Gal_Oxidase_b-propeller	KLHL11 KLHL12 KLHL8	6.40e-04	34	93	3	IPR015916
Domain	EGF_CA	HMCN2 TLL2 LRP2 LTBP2	8.96e-04	86	93	4	PF07645
Domain	EGF_Ca-bd_CS	HMCN2 TLL2 LRP2 LTBP2	1.40e-03	97	93	4	IPR018097
Domain	EGF_CA	HMCN2 TLL2 LRP2 LTBP2	1.51e-03	99	93	4	PS01187
Domain	-	RAG2 LZTR1 KLHL11	1.76e-03	48	93	3	2.120.10.80
Domain	EGF-type_Asp/Asn_hydroxyl_site	HMCN2 TLL2 LRP2 LTBP2	1.94e-03	106	93	4	IPR000152
Domain	MFS	SLC22A11 SLC22A2 SLC22A4 SLC22A5	2.08e-03	108	93	4	PS50850
Domain	Kelch-typ_b-propeller	RAG2 LZTR1 KLHL11	2.60e-03	55	93	3	IPR015915
Domain	EGF_CA	HMCN2 TLL2 LRP2 LTBP2	3.23e-03	122	93	4	SM00179
Domain	BACK	KLHL11 KLHL12 KLHL8	3.33e-03	60	93	3	SM00875
Domain	EGF-like_Ca-bd_dom	HMCN2 TLL2 LRP2 LTBP2	3.43e-03	124	93	4	IPR001881
Domain	BACK	KLHL11 KLHL12 KLHL8	3.49e-03	61	93	3	PF07707
Domain	BACK	KLHL11 KLHL12 KLHL8	3.49e-03	61	93	3	IPR011705
Domain	BTB	LZTR1 KLHL11 KLHL12 KLHL8	4.17e-03	131	93	4	PF00651
Domain	MFS_dom	SLC22A11 SLC22A2 SLC22A4 SLC22A5	4.52e-03	134	93	4	IPR020846
Domain	-	RGS5 RGS11	5.31e-03	22	93	2	1.10.196.10
Domain	DEP	RGS11 PLEK2	5.31e-03	22	93	2	PF00610
Domain	DEP	RGS11 PLEK2	5.31e-03	22	93	2	PS50186
Domain	RGS_subdom1	RGS5 RGS11	5.31e-03	22	93	2	IPR024066
Domain	DEP	RGS11 PLEK2	5.31e-03	22	93	2	SM00049
Domain	DEP_dom	RGS11 PLEK2	5.80e-03	23	93	2	IPR000591
Pathway	REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT	SLC22A11 SLC22A2 SLC22A4 SLC22A5	4.76e-07	15	63	4	M888
Pathway	REACTOME_ORGANIC_CATION_TRANSPORT	SLC22A2 SLC22A4 SLC22A5	4.69e-06	8	63	3	MM15191
Pathway	REACTOME_ORGANIC_CATION_TRANSPORT	SLC22A2 SLC22A4 SLC22A5	9.98e-06	10	63	3	M27450
Pathway	REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT	SLC22A2 SLC22A4 SLC22A5	1.82e-05	12	63	3	MM15192
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC22A11 SLC6A3 SLC22A2 SLC22A4 SLC22A5	3.57e-05	84	63	5	M27334
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A3 SLC22A2 SLC22A4 SLC22A5	3.65e-04	76	63	4	MM15072
Pathway	REACTOME_NEUROTRANSMITTER_CLEARANCE	SLC6A3 SLC22A2	5.41e-04	8	63	2	MM14500
Pubmed	A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	15685536
Pubmed	Functional variants of OCTN cation transporter genes are associated with Crohn disease.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	15107849
Pubmed	Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	16771961
Pubmed	Variants of OCTN1-2 cation transporter genes are associated with both Crohn's disease and ulcerative colitis.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	16441470
Pubmed	The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	16344054
Pubmed	OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	18756601
Pubmed	Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	16255050
Pubmed	Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn's disease.	NOD2 SLC22A4 SLC22A5	2.24e-08	3	99	3	17006998
Pubmed	Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases.	NOD2 SLC22A4 SLC22A5	8.93e-08	4	99	3	17451203
Pubmed	Risk factors for perianal Crohn's disease: the role of genotype, phenotype, and ethnicity.	NOD2 SLC22A4 SLC22A5	8.93e-08	4	99	3	17509030
Pubmed	Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD.	NOD2 SLC22A4 SLC22A5	8.93e-08	4	99	3	16344053
Pubmed	Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study.	NOD2 SLC22A4 SLC22A5	8.93e-08	4	99	3	16670523
Pubmed	rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.	NOD2 SLC22A4 SLC22A5	8.93e-08	4	99	3	17786191
Pubmed	Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.	NOD2 SLC22A4 SLC22A5	8.93e-08	4	99	3	16437728
Pubmed	Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.	NOD2 SLC22A4 SLC22A5	2.23e-07	5	99	3	17476680
Pubmed	The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.	NOD2 SLC22A4 SLC22A5	2.23e-07	5	99	3	18162085
Pubmed	Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy.	NOD2 SLC22A4 SLC22A5	2.23e-07	5	99	3	18698678
Pubmed	Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients.	NOD2 SLC22A4 SLC22A5	4.45e-07	6	99	3	18715515
Pubmed	Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk.	NOD2 SLC22A4 SLC22A5	4.45e-07	6	99	3	18433468
Pubmed	Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis.	NOD2 SLC22A4 SLC22A5	7.77e-07	7	99	3	17100974
Pubmed	Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms.	NOD2 SLC22A4 SLC22A5	4.83e-06	12	99	3	18804983
Pubmed	Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.	SLC22A2 SLC22A4 SLC22A5	6.27e-06	13	99	3	15369770
Pubmed	Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene.	SLC22A4 SLC22A5	8.02e-06	2	99	2	21695374
Pubmed	Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.	SLC22A4 SLC22A5	8.02e-06	2	99	2	16469794
Pubmed	Gene expression of carnitine organic cation transporters 1 and 2 (OCTN) is downregulated in patients with ulcerative colitis.	SLC22A4 SLC22A5	8.02e-06	2	99	2	21910182
Pubmed	Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan.	SLC22A4 SLC22A5	8.02e-06	2	99	2	18274826
Pubmed	Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids.	SLC22A4 SLC22A5	8.02e-06	2	99	2	19814996
Pubmed	Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons.	SLC22A4 SLC22A5	8.02e-06	2	99	2	21606177
Pubmed	Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.	SLC22A4 SLC22A5	8.02e-06	2	99	2	20020740
Pubmed	Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations.	SLC22A2 SLC22A4	8.02e-06	2	99	2	32149389
Pubmed	Association of the organic cation transporter OCTN genes with Crohn's disease in the Spanish population.	SLC22A4 SLC22A5	8.02e-06	2	99	2	16333318
Pubmed	Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients.	SLC22A4 SLC22A5	8.02e-06	2	99	2	21793125
Pubmed	Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells.	PRICKLE1 PRICKLE2	8.02e-06	2	99	2	22218901
Pubmed	SLC22A4 and SLC22A5 gene polymorphisms and Crohn's disease in the Chinese Han population.	SLC22A4 SLC22A5	8.02e-06	2	99	2	19659785
Pubmed	Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle.	PRICKLE1 PRICKLE2	8.02e-06	2	99	2	12525887
Pubmed	Characterization of organic cation/carnitine transporter family in human sperm.	SLC22A4 SLC22A5	8.02e-06	2	99	2	12788076
Pubmed	Mutations in prickle orthologs cause seizures in flies, mice, and humans.	PRICKLE1 PRICKLE2	8.02e-06	2	99	2	21276947
Pubmed	Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.	SLC22A4 SLC22A5	8.02e-06	2	99	2	21706137
Pubmed	Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease.	SLC22A4 SLC22A5	8.02e-06	2	99	2	22325173
Pubmed	Molecular and functional characterization of organic cation/carnitine transporter family in mice.	SLC22A4 SLC22A5	8.02e-06	2	99	2	11010964
Pubmed	Expression patterns of the organic cation/carnitine transporter family in adult murine brain.	SLC22A4 SLC22A5	8.02e-06	2	99	2	17576045
Pubmed	Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.	PRICKLE1 PRICKLE2	8.02e-06	2	99	2	34613779
Pubmed	Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).	SLC22A4 SLC22A5	8.02e-06	2	99	2	19141711
Pubmed	Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.	NOD2 GUCY2C	8.02e-06	2	99	2	30353760
Pubmed	Contribution of the IBD5 locus to Crohn's disease in the Swedish population.	SLC22A4 SLC22A5	8.02e-06	2	99	2	17340776
Pubmed	Prevalence of SLC22A4 1672T and SLC22A5 -207C combination defined TC haplotype in Hungarian ulcerative colitis patients.	SLC22A4 SLC22A5	8.02e-06	2	99	2	17387389
Pubmed	Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men.	SLC22A4 SLC22A5	8.02e-06	2	99	2	32964310
Pubmed	Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease.	SLC22A4 SLC22A5	8.02e-06	2	99	2	16835882
Pubmed	[Possible role of selected IGR and SLC22A4/SLC22A5 loci in development of inflammatory bowel diseases].	SLC22A4 SLC22A5	8.02e-06	2	99	2	19581171
Pubmed	Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth.	PRICKLE1 PRICKLE2	8.02e-06	2	99	2	17868671
Pubmed	Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort.	SLC22A4 SLC22A5	8.02e-06	2	99	2	16519742
Pubmed	Functional activity of L-carnitine transporters in human airway epithelial cells.	SLC22A4 SLC22A5	8.02e-06	2	99	2	26607009
Pubmed	OCTNs: will the real IBD5 gene please stand up?	SLC22A4 SLC22A5	8.02e-06	2	99	2	16773684
Pubmed	Organic cation/carnitine transporter family expression patterns in adult murine heart.	SLC22A4 SLC22A5	8.02e-06	2	99	2	19233567
Pubmed	Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium.	SLC22A4 SLC22A5	8.02e-06	2	99	2	18641280
Pubmed	Evidence for association of OCTN genes and IBD5 with ulcerative colitis.	SLC22A4 SLC22A5	8.02e-06	2	99	2	16361305
Pubmed	Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.	SLC22A4 SLC22A5	8.02e-06	2	99	2	16796743
Pubmed	GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.	SLC6A3 SNX27	8.02e-06	2	99	2	30228121
Pubmed	Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy.	SLC22A4 SLC22A5	8.02e-06	2	99	2	23127916
Pubmed	LPS-induced inflammation delays the transportation of ASP+ due to down-regulation of OCTN1/2 in alveolar epithelial cells.	SLC22A4 SLC22A5	8.02e-06	2	99	2	31591905
Pubmed	Screening of the interaction between xenobiotic transporters and PDZ proteins.	SLC22A11 SLC22A4 SLC22A5	9.93e-06	15	99	3	15553237
Pubmed	Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.	SLC22A2 SLC22A4 SLC22A5	1.22e-05	16	99	3	35307651
Pubmed	MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.	NOD2 MARCO	2.40e-05	3	99	2	23197261
Pubmed	Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients.	SLC22A4 SLC22A5	2.40e-05	3	99	2	19412005
Pubmed	Expression of the organic cation/carnitine transporter family (Octn1,-2 and-3) in mdx muscle and heart: Implications for early carnitine therapy in Duchenne muscular dystrophy to improve cellular carnitine homeostasis.	SLC22A4 SLC22A5	2.40e-05	3	99	2	32070725
Pubmed	Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.	PRICKLE1 PRICKLE2	2.40e-05	3	99	2	22037766
Pubmed	IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn's disease in Hungarian patients.	SLC22A4 SLC22A5	2.40e-05	3	99	2	19214536
Pubmed	Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.	KLHL11 KLHL12	2.40e-05	3	99	2	23349464
Pubmed	Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine.	RAG2 SLC6A3	2.40e-05	3	99	2	37248289
Pubmed	A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome.	PRICKLE1 PRICKLE2	2.40e-05	3	99	2	18976727
Pubmed	Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells.	DDR2 MMP2	2.40e-05	3	99	2	16967187
Pubmed	Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells.	PRICKLE1 PRICKLE2	2.40e-05	3	99	2	19788910
Pubmed	Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis.	SLC22A4 SLC22A5	2.40e-05	3	99	2	16652416
Pubmed	Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.	SLC22A4 SLC22A5	2.40e-05	3	99	2	15955786
Pubmed	Lack of association between IBD5 and Crohn's disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease.	SLC22A4 SLC22A5	2.40e-05	3	99	2	16373276
Pubmed	Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.	SLC22A4 SLC22A5	2.40e-05	3	99	2	33124720
Pubmed	Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.	SLC6A3 SNX27	2.40e-05	3	99	2	24811384
Pubmed	Primary Cilia Deficiency Induces Intracranial Aneurysm.	IFT88 MMP2	4.79e-05	4	99	2	28800037
Pubmed	Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5.	SLC22A4 SLC22A5	4.79e-05	4	99	2	18668679
Pubmed	Neuron-specific cilia loss differentially alters locomotor responses to amphetamine in mice.	SLC6A3 IFT88	4.79e-05	4	99	2	33175436
Pubmed	Transport of gabapentin by LAT1 (SLC7A5).	SLC22A4 SLC22A5	4.79e-05	4	99	2	23567998
Pubmed	A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5).	SLC22A4 SLC22A5	4.79e-05	4	99	2	12535646
Pubmed	Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase.	PRICKLE1 PRICKLE2	4.79e-05	4	99	2	25763846
Pubmed	Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.	PRICKLE1 PRICKLE2	4.79e-05	4	99	2	35420656
Pubmed	Association study of IL-17RC, CHL1, DSCAM and CNTNAP2 genes polymorphisms with adolescent idiopathic scoliosis susceptibility in a Chinese Han population.	CHL1 IL17RC	4.79e-05	4	99	2	22744455
Pubmed	Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium.	PRICKLE1 PRICKLE2	4.79e-05	4	99	2	36176272
Pubmed	Towards complete sets of farnesylated and geranylgeranylated proteins.	PRICKLE1 PRICKLE2	4.79e-05	4	99	2	17411337
Pubmed	[Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients].	NOD2 SLC22A4	4.79e-05	4	99	2	19103559
Pubmed	Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment.	RAG2 MMP2	4.79e-05	4	99	2	16397239
Pubmed	Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.	PRICKLE1 PRICKLE2	7.98e-05	5	99	2	27378169
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	LZTR1 KLHL11 KLHL12 KLHL8	1.15e-04	87	99	4	37495603
Pubmed	DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway.	DDR2 MMP2	1.19e-04	6	99	2	25733533
Pubmed	Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.	SLC22A4 SLC22A5	1.19e-04	6	99	2	17213842
Pubmed	Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.	SLC22A11 SLC22A2	1.19e-04	6	99	2	11907186
Pubmed	Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.	NOD2 SLC22A4	1.19e-04	6	99	2	18466472
Pubmed	PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2.	SLC22A4 SLC22A5	1.19e-04	6	99	2	15523054
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	PRICKLE1 PRICKLE2	1.67e-04	7	99	2	17937400
Pubmed	γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis.	RAG2 IL17RC	1.67e-04	7	99	2	32076265
Pubmed	New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.	MELK TMED8	1.67e-04	7	99	2	9136115
Pubmed	A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.	RGS5 DDR2	1.67e-04	7	99	2	15238534
GeneFamily	Prickle planar cell polarity proteins\|LIM domain containing	PRICKLE1 PRICKLE3 PRICKLE2	2.42e-07	4	72	3	1184
GeneFamily	LIM domain containing	PRICKLE1 PRICKLE3 PRICKLE2 LIMCH1	8.92e-05	59	72	4	1218
GeneFamily	Kelch like\|BTB domain containing	KLHL11 KLHL12 KLHL8	6.22e-04	42	72	3	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	LZTR1 KLHL11 KLHL12 KLHL8	2.01e-03	134	72	4	861
GeneFamily	Regulators of G-protein signaling	RGS5 RGS11	3.13e-03	21	72	2	720
Coexpression	ONDER_CDH1_TARGETS_2_UP	PRUNE2 WIPF1 DDR2 IL17RC SLC22A4 LTBP2 MMP2 REPS2	5.63e-06	257	98	8	M13867
Coexpression	ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN	WIPF1 GFI1 TESPA1 NIPBL	1.23e-05	38	98	4	M1751
Coexpression	ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN	WIPF1 GFI1 TESPA1 NIPBL	1.84e-05	42	98	4	MM733
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 HKDC1 PPP2R3A SLC22A2 SLC22A5 LRP2 WDR72	7.05e-09	180	99	8	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 HKDC1 PPP2R3A SLC22A2 SLC22A5 LRP2 WDR72	8.73e-09	185	99	8	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 GAS2L3 SLC22A11 PPP2R3A SLC22A2 SLC22A5 LRP2 WDR72	9.50e-09	187	99	8	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 GAS2L3 PPP2R3A SLC22A2 SLC22A5 LRP2 HRH1 WDR72	1.03e-08	189	99	8	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PRICKLE1 HKDC1 PPP2R3A SLC22A2 SLC22A5 LRP2 WDR72	1.12e-08	191	99	8	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PRICKLE1 HKDC1 PPP2R3A SLC22A2 SLC22A5 LRP2 WDR72	1.12e-08	191	99	8	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 HKDC1 PPP2R3A SLC22A2 LRP2 WDR72	1.59e-07	180	99	7	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 HKDC1 PPP2R3A SLC22A2 LRP2 FAM149A WDR72	1.72e-07	182	99	7	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 HKDC1 PPP2R3A SLC22A2 LRP2 WDR72	1.78e-07	183	99	7	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 SLC22A11 HKDC1 PPP2R3A SLC22A2 SLC22A4 LRP2	1.99e-07	186	99	7	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	LA\|World / Chamber and Cluster_Paper	PRUNE2 DDR2 HMCN2 PDE8B PRICKLE2 LRP2 LTBP2	2.56e-07	193	99	7	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 HKDC1 SLC6A3 TLL2 LRP2 HRH1	1.46e-06	158	99	6	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 HKDC1 SLC6A3 TLL2 LRP2 HRH1	1.46e-06	158	99	6	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	RGS11 TYRP1 LTBP2 MMP2 C1GALT1C1L FAM149A	2.73e-06	176	99	6	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	RGS11 TYRP1 LTBP2 MMP2 C1GALT1C1L FAM149A	2.73e-06	176	99	6	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	CRIM1 RGS11 TYRP1 LTBP2 LIMCH1 MMP2	2.82e-06	177	99	6	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CRIM1 RGS11 TYRP1 LTBP2 LIMCH1 MMP2	2.82e-06	177	99	6	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 NAT8 SLC22A2 LRP2 WDR72	2.91e-06	178	99	6	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRICKLE2 LIMCH1 NRSN1 REPS2 FAM149A WDR72	2.91e-06	178	99	6	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 HKDC1 SLC22A2 LRP2 WDR72	3.21e-06	181	99	6	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 SLC22A2 SLC22A5 LRP2 WDR72	3.52e-06	184	99	6	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 PRUNE2 PPP2R3A IFT88 HRH1 REPS2	3.75e-06	186	99	6	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 PRUNE2 PPP2R3A IFT88 HRH1 REPS2	3.87e-06	187	99	6	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 HKDC1 PPP2R3A SLC22A2 LRP2 WDR72	3.87e-06	187	99	6	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	COVID-19-kidney-Mito-rich_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A11 SLC22A2 SLC22A5 LRP2 WDR72	3.87e-06	187	99	6	738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 PRUNE2 PPP2R3A IFT88 HRH1 REPS2	3.99e-06	188	99	6	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGS5 SLC4A1AP PDE8B PRICKLE2 KLHL8 TRIM37	4.11e-06	189	99	6	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RGS5 IFIT3 USP31 PRICKLE2 HRH1 AMMECR1	4.24e-06	190	99	6	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PRICKLE1 HKDC1 SLC22A2 PRICKLE2 LRP2	4.37e-06	191	99	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|356C / Donor, Lineage, Cell class and subclass (all cells)	PRUNE2 LZTR1 NOD2 ZNF764 MARCO	2.83e-05	159	99	5	24f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC22A2 LRP2 HRH1 WDR72	3.68e-05	168	99	5	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GAS2L3 MELK LRRC9 LIMCH1 MMP2	3.79e-05	169	99	5	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	DDR2 TYRP1 ASTN1 LTBP2 MMP2	4.24e-05	173	99	5	75e26a65071b0d2f30ed0b2aa9859c488f5cf362
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	DDR2 TYRP1 ASTN1 LTBP2 MMP2	4.24e-05	173	99	5	26e2e674f5d312fa8f61c11b553dc6101f063b16
ToppCell	Tuft-tuft-4\|World / Class top	IFIT3 S100A3 KLHL11 TMED8 LIMCH1	4.35e-05	174	99	5	d6f306ebf66061bf9e9742000bfedce12d277452
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	DDR2 S100A3 TYRP1 PDE8B LTBP2	4.47e-05	175	99	5	fed9e4120c758fdcc23bb248d1801002b0e0d485
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	S100A3 SLC6A3 P2RY2 MMP2	4.67e-05	89	99	4	9e7041ab9409028007fefe53db6d1048eafae93b
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	S100A3 SLC6A3 P2RY2 MMP2	4.67e-05	89	99	4	436e1229ee28517c11dfe0a5d1cdad3477419e00
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	S100A3 SLC6A3 P2RY2 MMP2	4.67e-05	89	99	4	e7abf4af18d63c9384d25365a827e85a9adee964
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	S100A3 SLC6A3 P2RY2 MMP2	4.67e-05	89	99	4	4e5f4c0404968422703c248488e6b2ee8737dc00
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)\|343B / Donor, Lineage, Cell class and subclass (all cells)	DDR2 TYRP1 PDE8B LTBP2 MMP2	4.72e-05	177	99	5	e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DDR2 TYRP1 PDE8B LTBP2 MMP2	4.72e-05	177	99	5	43ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 PPP2R3A LRP2 HRH1 WDR72	4.85e-05	178	99	5	544379f5a6145429762258d426b876bb36c112f5
ToppCell	390C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KRT85 IFT88 SLC22A5 DTX2 TRIM37	4.98e-05	179	99	5	3edcd1356e49b1f5514c585861999e079ca5e579
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 TYRP1 OSBPL9 LTBP2 MMP2	5.25e-05	181	99	5	9c157de9d3403e092c907599f2a2c16db5b21131
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 TYRP1 OSBPL9 LTBP2 MMP2	5.25e-05	181	99	5	eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 RGS11 TYRP1 LTBP2 MMP2	5.82e-05	185	99	5	7b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 RGS11 TYRP1 LTBP2 MMP2	5.82e-05	185	99	5	e9033a03d574956cf3ae228740b3166e40a6397f
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 RGS11 TYRP1 LTBP2 MMP2	5.82e-05	185	99	5	578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PRICKLE1 PPP2R3A LRP2 HRH1	5.98e-05	186	99	5	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 SLC22A11 SLC22A5 LRP2 WDR72	5.98e-05	186	99	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 HKDC1 SLC22A5 LRP2 WDR72	6.13e-05	187	99	5	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RGS5 IFIT3 USP31 HRH1 AMMECR1	6.13e-05	187	99	5	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RGS5 S100A3 HMCN2 SLC22A2 LTBP2	6.29e-05	188	99	5	0a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RGS5 PLEK2 P2RY2 MMP2	6.29e-05	188	99	5	ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RGS5 IFIT3 USP31 PRICKLE2 HRH1	6.29e-05	188	99	5	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 SLC22A11 SLC22A2 LRP2 WDR72	6.44e-05	189	99	5	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 SLC22A11 SLC22A2 LRP2 WDR72	6.44e-05	189	99	5	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PRICKLE1 HKDC1 PRICKLE2 LRP2	6.61e-05	190	99	5	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PRICKLE1 DDR2 LTBP2 LIMCH1 MMP2	6.77e-05	191	99	5	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PRICKLE1 DDR2 LTBP2 LIMCH1 MMP2	6.77e-05	191	99	5	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	DDR2 PRICKLE2 LTBP2 LIMCH1 MMP2	7.11e-05	193	99	5	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PPP2R3A SLC22A5 LRP2 WDR72	7.11e-05	193	99	5	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	(5)_Fibroblast-C_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	DDR2 TYRP1 LTBP2 LIMCH1 MMP2	7.29e-05	194	99	5	29a72e565c19407bbd198cfbc2a78106fe830d05
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	DDR2 HMCN2 PRICKLE2 OSBPL9 LTBP2	7.47e-05	195	99	5	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	PRICKLE1 DDR2 PRICKLE2 LTBP2 MMP2	7.84e-05	197	99	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 PRUNE2 PPP2R3A HRH1 REPS2	7.84e-05	197	99	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RAG2 MELK LRRC9 SLC22A2 CLEC19A	8.22e-05	199	99	5	92778939e9d06599c7d06cfd8f4362b97ed0606b
ToppCell	proximal-mesenchymal-Fibromyocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRUNE2 TYRP1 HMCN2 LTBP2 MMP2	8.41e-05	200	99	5	37d9f46f727a31e8e94e348e4ddd71a2125ba01a
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRUNE2 WIPF1 DDR2 LTBP2 MMP2	8.41e-05	200	99	5	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR2 TYRP1 LTBP2 LIMCH1 MMP2	8.41e-05	200	99	5	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	proximal-3-mesenchymal-Fibromyocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRUNE2 TYRP1 HMCN2 LTBP2 MMP2	8.41e-05	200	99	5	ed6fbe61a04d29b105054f7058abe7469314b304
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TYRP1 PDE8B OSBPL9 LTBP2 MMP2	8.41e-05	200	99	5	251fd2923f108cd2086961d897244b392c32ad54
ToppCell	Kidney\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	RGS5 IFIT3 SLC22A2 LRP2 WDR72	8.41e-05	200	99	5	1f99afa1f3c32a2a9cfb4ad33ff4d404e34fac63
ToppCell	severe-CD163+_Monocytes_(Sample_ID1_d7)\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CPPED1 IFIT3 NOD2 MARCO MTARC1	8.41e-05	200	99	5	4943fe826d5fcc3dfeb8b99a7415848f3fecc994
ToppCell	proximal-mesenchymal-Fibromyocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRUNE2 TYRP1 HMCN2 LTBP2 MMP2	8.41e-05	200	99	5	49658e1b530de0dad16d45a1112bdf5329bb800d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRUNE2 TLL2 LRP2 LIMCH1 TMEM63A	8.41e-05	200	99	5	829978708463a7459fe1041bd90196775bc4b531
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse\|TCGA-Stomach / Sample_Type by Project: Shred V9	WIPF1 IFFO1 ARRDC5 TESPA1	1.97e-04	129	99	4	7d537680b0dfb764f7914d0475c66b678b5cb8d2
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGS5 IFFO1 HKDC1 GUCY2C	1.97e-04	129	99	4	cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CHL1 GAS2L3 S100A3	2.36e-04	54	99	3	68c762094ea29e321a6fd4f6d9b598431023fa7b
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CHL1 GAS2L3 S100A3	2.36e-04	54	99	3	7816e6541e3a9e702f25bd102a95ce963ce31535
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RBM44 HKDC1 MELK USP31	2.62e-04	139	99	4	7c02caed5b9baf233bd6fb9a453708b3e157c790
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LZTR1 TMEM104 KLHL11 ZNF764	3.07e-04	145	99	4	e808502fa52baf1c400f3c9b918a167127e78af9
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBM44 USP9Y SLC6A3 MARCO	3.07e-04	145	99	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERO1B WIPF1 ARRDC5 TRIM37	3.49e-04	150	99	4	207fc230d7721149c7afc7970dd56817f52801d8
ToppCell	TCGA-Kidney\|World / Sample_Type by Project: Shred V9	SLC22A11 SLC22A2 SLC22A5 LRP2	3.58e-04	151	99	4	e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS2L3 CHRNE PDE8B HRH1	3.67e-04	152	99	4	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	CHL1 PRICKLE1 USP31 ERMARD	3.96e-04	155	99	4	e1a20e88b9c0eaf7ca7004acc0eda096d1588563
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	DHX57 USP9Y NOD2 LRP2	4.05e-04	156	99	4	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DDR2 USP9Y PLEK2 LIMCH1	4.15e-04	157	99	4	542944030cd9b3f3559e64f9f6598694d74003c0
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CRIM1 KLHL11 LIMCH1 REPS2	4.46e-04	160	99	4	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CRIM1 KLHL11 LIMCH1 REPS2	4.46e-04	160	99	4	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	USP9Y SFMBT2 SLC6A3 MARCO	4.67e-04	162	99	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 HKDC1 SLC22A2 LRP2	4.89e-04	164	99	4	382e42701779d12a7948690b3be72d06dd75c8b4
ToppCell	11.5-Airway-RBC-RBC\|Airway / Age, Tissue, Lineage and Cell class	RAG2 TESPA1 PLEK2 SLC22A4	5.01e-04	165	99	4	8618b2c5659aa70c7c9d6e51a227ac612b4ad17b
ToppCell	11.5-Airway-RBC\|Airway / Age, Tissue, Lineage and Cell class	RAG2 TESPA1 PLEK2 SLC22A4	5.01e-04	165	99	4	46042340a373adaf1c439b2301e02fbae3e31a4f
ToppCell	LV-16._Neuronal\|World / Chamber and Cluster_Paper	CHL1 CPPED1 WIPF1 GAS2L3	5.01e-04	165	99	4	6ed52cb756d21addf46c7f6c457458b01339fe04
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRICKLE1 DDR2 GFI1 TRIM37	5.12e-04	166	99	4	ceb0a48c0d853448fd45ac31dde046df9a178571
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC6A3 TYRP1 GUCY2C AMMECR1	5.12e-04	166	99	4	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HKDC1 RGS11 LRRC9 LTBP2	5.24e-04	167	99	4	cf6206c506715cd846799c62cf7c06e3fa99f7af
Drug	Pyrilamine	SLC6A3 SLC22A2 SLC22A5 HRH1	9.05e-07	18	97	4	ctd:D011738
Drug	Ipratropium	SLC22A2 SLC22A4 SLC22A5	2.59e-06	7	97	3	ctd:D009241
Drug	Probenecid	SLC22A11 SLC6A3 SLC22A2 SLC22A4 SLC22A5	5.28e-06	59	97	5	ctd:D011339
Drug	Cyproheptadine	SLC22A2 SLC22A5 HRH1	1.21e-05	11	97	3	ctd:D003533
Drug	potassium oxonate	SLC22A2 SLC22A4 SLC22A5	1.60e-05	12	97	3	ctd:C489337
Drug	2-propylpentanoic acid; Up 200; 200uM; MCF7; HT_HG-U133A_EA	LZTR1 GFI1 DEGS1 ZNF34 PDE8B SLC22A4 LIMCH1	1.78e-05	191	97	7	994_UP
Drug	Diphenylpyraline	SLC6A3 HRH1	1.80e-05	2	97	2	DB01146
Drug	Tiapride hydrochloride [51012-33-0]; Up 200; 11uM; MCF7; HT_HG-U133A	WIPF1 GFI1 TYRP1 PDE8B SLC22A4 LRP2 LIMCH1	2.03e-05	195	97	7	4686_UP
Drug	Reserpinic acid hydrochloride; Up 200; 9.2uM; MCF7; HT_HG-U133A	PRUNE2 HBS1L WIPF1 ZNF34 PDE8B LIMCH1 SPSB3	2.03e-05	195	97	7	7323_UP
Drug	angelicin	SLC22A2 SLC22A4 SLC22A5	2.08e-05	13	97	3	ctd:C011659
Drug	Dimethadione [695-53-4]; Up 200; 31uM; PC3; HT_HG-U133A	PRUNE2 RAG2 GFI1 TESPA1 NOD2 SLC22A2 FAM149A	2.10e-05	196	97	7	4607_UP
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; PC3; HT_HG-U133A	HBS1L RGS11 TESPA1 S100A3 ZNF747 CFAP44 TMEM63A	2.10e-05	196	97	7	6863_DN
Drug	Tremorine dihydrochloride [300-68-5]; Up 200; 15uM; MCF7; HT_HG-U133A	WIPF1 RGS5 IFFO1 PPP2R3A PRICKLE3 ZNF747 ASTN1	2.17e-05	197	97	7	3196_UP
Drug	Colchicine [64-86-8]; Down 200; 10uM; MCF7; HT_HG-U133A	PPP2R3A PRICKLE3 PDE8B ZNF764 ZNF747 LTBP2 LIMCH1	2.17e-05	197	97	7	5675_DN
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A	HBS1L CHRNE KLHL11 TYRP1 PDE8B LTBP2 TMEM63A	2.24e-05	198	97	7	6458_UP
Drug	ICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A	AGBL5 PIAS4 PRICKLE3 ZNF764 HRH1 REPS2 TMEM63A	2.24e-05	198	97	7	6197_DN
Drug	SC-560; Down 200; 10uM; PC3; HT_HG-U133A	RGS11 IFIT3 TESPA1 S100A3 ZNF747 CFAP44 TMEM63A	2.24e-05	198	97	7	6865_DN
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	IFIT3 NOD2 PDE8B SLC22A5 LTBP2 SPSB3 TMEM63A	2.39e-05	200	97	7	6167_UP
Drug	Ficusin	SLC22A2 SLC22A4 SLC22A5	3.29e-05	15	97	3	ctd:D005363
Drug	Tetraethylammonium	SLC22A2 SLC22A4 SLC22A5	4.03e-05	16	97	3	ctd:D019789
Drug	Diphenhydramine	SLC22A2 SLC22A5 HRH1	4.88e-05	17	97	3	ctd:D004155
Drug	Benzatropine	SLC6A3 HRH1	5.37e-05	3	97	2	DB00245
Drug	Dithioerythritol	SLC22A4 SLC22A5	1.07e-04	4	97	2	ctd:D004226
Drug	Chlorpheniramine	SLC6A3 HRH1	1.07e-04	4	97	2	DB01114
Drug	Tripelennamine	SLC22A2 HRH1	1.07e-04	4	97	2	ctd:D014309
Drug	lamtidine	TYRP1 HRH1	1.07e-04	4	97	2	CID000071988
Drug	Benztropine	SLC6A3 SLC22A2	1.07e-04	4	97	2	ctd:D001590
Drug	bromcresol green	RAG2 DDR2 IFIT3 NOD2 MMP2	1.09e-04	110	97	5	CID000006451
Drug	imperatorin	SLC22A2 SLC22A4 SLC22A5	1.09e-04	22	97	3	ctd:C031534
Drug	Gabexate mesilate [56974-61-9]; Up 200; 9.6uM; HL60; HT_HG-U133A	RGS5 PDE8B ZNF747 REPS2 MTARC1 TMEM63A	1.22e-04	180	97	6	2937_UP
Drug	N1-methylnicotinamide	SLC22A4 SLC22A5 MMP2	1.25e-04	23	97	3	CID000000457
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A	DEGS1 PPP2R3A P2RY2 NIPBL MED13 TMEM63A	1.64e-04	190	97	6	2619_DN
Drug	prinomastat	SLC22A2 MMP2	1.78e-04	5	97	2	ctd:C113282
Drug	AC1NV8Y2	SLC22A4 SLC22A5	1.78e-04	5	97	2	CID005473939
Drug	4-ethylcatechol	SLC6A3 TRIM37	1.78e-04	5	97	2	CID000070761
Drug	Fluorometholone [426-13-1]; Up 200; 10.6uM; HL60; HT_HG-U133A	RGS5 IFIT3 PDE8B TLL2 LTBP2 MTARC1	1.79e-04	193	97	6	2509_UP
Drug	2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A	DHX57 NOD2 PDE8B SLC22A5 LTBP2 FAM149A	1.84e-04	194	97	6	6173_UP
Drug	Apigenin [520-36-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A	WIPF1 IFFO1 KRT85 TESPA1 SLC6A3 HRH1	1.84e-04	194	97	6	4401_UP
Drug	Azapropazone [13539-59-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ZNF764 LRP2 LTBP2 MMP2 CFAP44 TMEM63A	1.89e-04	195	97	6	6522_DN
Drug	haloperidol; Down 200; 10uM; HL60; HT_HG-U133A	PRRG2 IFIT3 URGCP PIAS4 HRH1 TMEM63A	1.89e-04	195	97	6	6163_DN
Drug	Pregnenolone [145-13-1]; Down 200; 12.6uM; PC3; HT_HG-U133A	WIPF1 IFIT3 ZNF34 LTBP2 LIMCH1 TMEM63A	1.94e-04	196	97	6	4218_DN
Drug	Prednisolone [50-24-8]; Down 200; 11uM; HL60; HT_HG-U133A	DHX57 IL17RC PIAS4 LRP2 ZNF747 TMEM63A	1.94e-04	196	97	6	2393_DN
Drug	Evoxine [522-11-2]; Down 200; 11.6uM; HL60; HT_HG-U133A	RGS5 PIAS4 PRICKLE3 SLC22A5 ZNF747 TMEM63A	1.94e-04	196	97	6	2186_DN
Drug	Ethamsylate [2624-44-4]; Up 200; 15.2uM; HL60; HT_HG-U133A	KRT85 NOD2 ZNF34 PDE8B LIMCH1 TMEM63A	1.94e-04	196	97	6	2915_UP
Drug	Lovastatin [75330-75-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A	HBS1L ZNF34 ZNF747 LIMCH1 SPSB3 TMEM63A	1.94e-04	196	97	6	4978_DN
Drug	Nalidixic acid sodium salt hydrate; Down 200; 14.6uM; PC3; HT_HG-U133A	DHX57 AGBL5 PRICKLE3 SLC22A4 HRH1 NIPBL	1.94e-04	196	97	6	7367_DN
Drug	LY294002; Up 200; 10uM; ssMCF7; HG-U133A	TESPA1 PIAS4 TLL2 LRP2 MTARC1 TMEM63A	2.00e-04	197	97	6	401_UP
Drug	Sulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A	PRUNE2 HBS1L RGS5 PPP2R3A MARCO TMEM63A	2.00e-04	197	97	6	3192_UP
Drug	(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; MCF7; HT_HG-U133A	WIPF1 CRIM1 GFI1 TYRP1 PDE8B LRP2	2.00e-04	197	97	6	3355_DN
Drug	Mephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	CPPED1 LZTR1 TMEM104 PPP2R3A SLC4A1AP SPSB3	2.00e-04	197	97	6	3425_DN
Drug	Guanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; HL60; HT_HG-U133A	HBS1L CRIM1 URGCP ZNF34 MTARC1 TMEM63A	2.00e-04	197	97	6	1279_UP
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; PC3; HT_HG-U133A	CPPED1 RGS5 DHX57 IL17RC LRP2 LIMCH1	2.00e-04	197	97	6	4277_DN
Drug	U-62066 [87151-85-7]; Down 200; 1uM; PC3; HT_HG-U133A	RGS5 IL17RC PRICKLE3 ZNF747 NIPBL TMEM63A	2.00e-04	197	97	6	4553_DN
Drug	Isopyrin hydrochloride [18342-39-7]; Up 200; 14.2uM; MCF7; HT_HG-U133A	PRUNE2 LZTR1 ERO1B IFFO1 CHRNE SLC22A2	2.00e-04	197	97	6	6097_UP
Drug	Quipazine dimaleate salt [4774-24-7]; Down 200; 9uM; MCF7; HT_HG-U133A	PRRG2 GFI1 TYRP1 LIMCH1 MMP2 TMEM63A	2.00e-04	197	97	6	2782_DN
Drug	Oxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; MCF7; HT_HG-U133A	RGS11 TESPA1 PPP2R3A LTBP2 TMEM63A FAM149A	2.05e-04	198	97	6	3170_UP
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	IL17RC PPP2R3A ZNF747 LIMCH1 MMP2 TMEM63A	2.05e-04	198	97	6	3882_DN
Drug	Dapsone [80-08-0]; Down 200; 16.2uM; HL60; HT_HG-U133A	HBS1L ERO1B CRIM1 URGCP ZNF764 ZNF747	2.05e-04	198	97	6	1868_DN
Drug	Oxethazaine [126-27-2]; Up 200; 8.6uM; PC3; HT_HG-U133A	RGS5 IFIT3 LRP2 ZNF747 MMP2 TMEM63A	2.05e-04	198	97	6	4246_UP
Drug	Neomycin sulfate [1405-10-3]; Up 200; 4.2uM; PC3; HT_HG-U133A	CPPED1 LZTR1 WIPF1 KRT85 IL17RC ZNF34	2.05e-04	198	97	6	2066_UP
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; PC3; HT_HG-U133A	RAG2 GFI1 CHRNE TLL2 LRP2 ASTN1	2.05e-04	198	97	6	3778_UP
Drug	Glutethimide, para-amino [125-84-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A	PLEK2 PPP2R3A ZNF747 MMP2 CFAP44 TMEM63A	2.05e-04	198	97	6	7421_UP
Drug	Pinacidil [85371-64-8]; Up 200; 16.4uM; HL60; HT_HG-U133A	PRRG2 CPPED1 NOD2 ZNF34 PRICKLE3 PDE8B	2.11e-04	199	97	6	2406_UP
Drug	Natamycin [7681-93-8]; Down 200; 6uM; PC3; HT_HG-U133A	LZTR1 DEGS1 ZNF764 SLC22A5 LIMCH1 TMEM63A	2.11e-04	199	97	6	5809_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; MCF7; HT_HG-U133A	PRUNE2 ERO1B WIPF1 IL17RC LIMCH1 SPSB3	2.11e-04	199	97	6	5433_UP
Drug	Dimenhydrinate [523-87-5]; Down 200; 8.6uM; HL60; HT_HG-U133A	IL17RC SLC22A5 LRP2 ZNF747 LTBP2 CFAP44	2.11e-04	199	97	6	2400_DN
Drug	Trolox [53188-07-1]; Down 200; 16uM; MCF7; HT_HG-U133A	HBS1L TMEM104 ZNF747 NIPBL SPSB3 TMEM63A	2.11e-04	199	97	6	2883_DN
Drug	Kawain [500-64-1]; Up 200; 17.4uM; HL60; HT_HG-U133A	PRUNE2 RGS5 IFFO1 IL17RC LRP2 TMEM63A	2.11e-04	199	97	6	2337_UP
Drug	Cefoxitin sodium salt [33564-30-6]; Down 200; 8.8uM; PC3; HT_HG-U133A	ARID4A TMEM104 MELK ZNF764 NIPBL TMEM63A	2.11e-04	199	97	6	7148_DN
Drug	Ornidazole [16773-42-5]; Down 200; 18.2uM; PC3; HT_HG-U133A	PRRG2 LZTR1 ZNF34 PRICKLE3 ZNF764 REPS2	2.11e-04	199	97	6	2109_DN
Drug	Zoxazolamine [61-80-3]; Up 200; 23.8uM; HL60; HT_HG-U133A	IFFO1 TMEM104 ZNF34 PRICKLE3 HRH1 TMEM63A	2.11e-04	199	97	6	1270_UP
Drug	N-Acetyl-L-leucine [1188-21-2]; Up 200; 23uM; MCF7; HT_HG-U133A	HBS1L ERO1B RGS11 PDE8B LRP2 TMEM63A	2.11e-04	199	97	6	6462_UP
Drug	benserazide hydrochloride; Down 200; 10uM; MCF7; HG-U133A	WIPF1 IFFO1 KRT85 PIAS4 HRH1 TMEM63A	2.11e-04	199	97	6	641_DN
Drug	Iproniazide phosphate [305-33-9]; Up 200; 14.4uM; HL60; HG-U133A	HBS1L ARID4A KRT85 RGS11 AGBL5 TLL2	2.11e-04	199	97	6	1442_UP
Drug	Diazoxide [364-98-7]; Up 200; 17.4uM; HL60; HG-U133A	CRIM1 SLC6A3 PLEK2 PIAS4 SLC22A4 ZNF747	2.17e-04	200	97	6	1368_UP
Drug	Simvastatin [79902-63-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CPPED1 DEGS1 PPP2R3A ZNF747 LTBP2 LIMCH1	2.17e-04	200	97	6	4828_DN
Drug	Escitalopram	SLC6A3 HRH1	2.66e-04	6	97	2	DB01175
Drug	ebastine	SLC22A5 HRH1	2.66e-04	6	97	2	ctd:C058249
Disease	tryptophan betaine measurement	IFT88 SLC22A4 SLC22A5	7.19e-06	12	96	3	EFO_0021017
Disease	Coxsackievirus Infections	SLC22A4 SLC22A5	1.56e-04	6	96	2	C0010246
Disease	Myocarditis	SLC22A4 SLC22A5	1.56e-04	6	96	2	C0027059
Disease	Carditis	SLC22A4 SLC22A5	1.56e-04	6	96	2	C0869523
Disease	creatinine measurement, chronic kidney disease	NAT8 SLC22A2 WDR72	2.03e-04	35	96	3	EFO_0003884, EFO_0004518
Disease	acetylcarnitine measurement	SLC22A4 SLC22A5	2.90e-04	8	96	2	EFO_0021038
Disease	butyrylcarnitine measurement	SLC22A4 SLC22A5	2.90e-04	8	96	2	EFO_0020010
Disease	nervonoylcarnitine (C24:1) measurement	SLC22A4 SLC22A5	3.72e-04	9	96	2	EFO_0800549
Disease	lignoceroylcarnitine (C24) measurement	SLC22A4 SLC22A5	5.65e-04	11	96	2	EFO_0800541
Disease	Marfan Syndrome	LTBP2 MMP2	5.65e-04	11	96	2	C0024796
Disease	Crohn Disease	NOD2 SLC22A4 SLC22A5	5.85e-04	50	96	3	C0010346
Disease	creatinine measurement, glomerular filtration rate	NAT8 SLC22A2 LRP2 WDR72	5.89e-04	117	96	4	EFO_0004518, EFO_0005208
Disease	hexanoylcarnitine measurement	SLC22A4 SLC22A5	6.77e-04	12	96	2	EFO_0021040
Disease	homostachydrine measurement	SLC22A4 SLC22A5	7.98e-04	13	96	2	EFO_0021164
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	SLC22A4 SLC22A5	7.98e-04	13	96	2	EFO_0800547
Disease	cerotoylcarnitine (C26) measurement	SLC22A4 SLC22A5	7.98e-04	13	96	2	EFO_0800542
Disease	cirrhosis of liver	KLHL8 MTARC1	7.98e-04	13	96	2	EFO_0001422
Disease	testosterone measurement	CPPED1 RGS5 SLC22A11 HKDC1 ZNF785 GFI1 P2RY2 SLC4A1AP PDE8B SLC22A2 KLHL8 WDR72	8.82e-04	1275	96	12	EFO_0004908
Disease	Metabolic Bone Disorder	LRP2 MMP2	9.29e-04	14	96	2	C0005944
Disease	high grade glioma (biomarker_via_orthology)	SLC6A3 MMP2	1.07e-03	15	96	2	DOID:3070 (biomarker_via_orthology)
Disease	Osteopenia	LRP2 MMP2	1.07e-03	15	96	2	C0029453
Disease	periprosthetic osteolysis, disease progression measurement	RGS5 SFMBT2	1.07e-03	15	96	2	EFO_0008336, EFO_0009761
Disease	IGF-1 measurement	ARRDC5 AGBL5 PPP2R3A SLC22A2 ASTN1 SPSB3 MTARC1	1.09e-03	488	96	7	EFO_0004627
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	SLC22A2 SLC22A4 SLC22A5 MTARC1	1.48e-03	150	96	4	EFO_0004611, EFO_0020947
Disease	Craniofacial Abnormalities	LRP2 MMP2 NIPBL TRIM37	1.71e-03	156	96	4	C0376634
Disease	oleoylcarnitine measurement	SLC22A4 SLC22A5	1.73e-03	19	96	2	EFO_0021043
Disease	myelodysplastic syndrome (is_marker_for)	GFI1 SLC22A5	1.92e-03	20	96	2	DOID:0050908 (is_marker_for)
Disease	epilepsy (implicated_via_orthology)	CHL1 PRICKLE1 PRICKLE3 PRICKLE2	2.01e-03	163	96	4	DOID:1826 (implicated_via_orthology)
Disease	metabolite measurement	SMNDC1 DDR2 NAT8 SLC22A2 SLC22A4 SLC22A5 ZMYM1	2.38e-03	560	96	7	EFO_0004725
Disease	Attention deficit hyperactivity disorder	SLC6A3 MED13	2.76e-03	24	96	2	C1263846
Disease	stearoylcarnitine measurement	SLC22A4 SLC22A5	2.76e-03	24	96	2	EFO_0021045

Protein segments in the cluster

Peptide	Gene	Start	Entry
DYEFNVWTRPDCAET	AGBL5	51	Q8NDL9
ASWYTVVFDDGDERT	ARID4A	86	P29374
EDDGESFYTWLEGLC	ERO1B	226	Q86YB8
EWYETDDFVIDCCTS	GVINP1	2321	Q7Z2Y8
DGYVRIWDFETIDTA	CFAP44	386	Q96MT7
HYESFGEFTWRCEDE	ASTN1	1206	O14525
TEAYTENGEWAIDFC	CHRNE	196	Q04844
TDGYRWCGTTEDYDR	MMP2	311	P08253
DEEDESETGYWITCC	RAG2	406	P55895
GDKDCRHYQETSEDW	RBM44	771	Q6ZP01
SFWEACEELRYGAQA	RGS11	331	O94810
GTETEDCFWYLNALE	GUCY2C	196	P25092
SFAYAWVLDETGEER	HBS1L	306	Q9Y450
TRLFHEDGECWVYDE	OSBPL9	711	Q96SU4
EEGTRSDDWFNFCYE	LRRC9	396	Q6ZRR7
LIDYDWCEDDLSTGA	MELK	371	Q14680
EDYGRLWESRQFCDV	LZTR1	431	Q8N653
IVISGCDVYAEDSWD	MTARC1	241	Q5VT66
EEDAGSYSCWVENAI	CHL1	486	O00533
EGSVCERSSEFEDFW	GFI1	76	Q99684
TERGSVYSWRDDEFD	FAM149A	261	A5PLN7
SRAEAESWYRSKCEE	KRT85	306	P78386
EVQCYFRSEASEWEP	DDR2	301	Q16832
SDDGSWTAYEASVCD	DTX2	116	Q86UW9
VDRADVWDAGHYTCE	HMCN2	2136	Q8NDA2
RGYVEWSEEAGASCD	ARRDC5	61	A6NEK1
CFNDVERYDIESDQW	KLHL8	426	Q9P2G9
LCIEWAGRISEEYFA	PDE8B	791	O95263
DCTASIWEYEDDFQI	NRSN1	36	Q8IZ57
VVAACRDTGYDWFEQ	NIPBL	1936	Q6KC79
VEAGDEADYYCQVWD	IGLV3-21	96	P80748
SRAEAESWYRSKCEE	KRT87P	121	A6NCN2
DVDVSSGFIYWCDFS	LRP2	2101	P98164
WYCDQETDCFDASDE	LRP2	2881	P98164
EVLGCEWEDAISYYT	TMEM63A	311	O94886
SIEYWFRCMDVDGDG	PPP2R3A	976	Q06190
WDGDELGYRCRFNED	P2RY2	16	P41231
IEAGDEADYYCQVWD	IGLV3-12	96	A0A075B6K2
REYDFEDDCDSLTWE	IFFO1	411	Q0D2I5
TSDDDSGCALEEYAW	PRICKLE1	21	Q96MT3
SDDDSGCALEEYAWV	PRICKLE2	26	Q7Z3G6
ISDDDSGCASEEYAW	PRICKLE3	81	O43900
ETSFAAGYDWCVEVV	IFT88	391	Q13099
ECVGYFVDEDRWVNL	KLHL11	376	Q9NVR0
VECLDYTADEDGVWY	KLHL12	346	Q53G59
WCRDIGVDETYLFES	GAS2L3	131	Q86XJ1
RIWDDGDDFCIFSES	DHX57	56	Q6P158
YSIEYSELDCEEGWT	IFIT3	131	O14879
FCIIFGESEDESYWA	C1GALT1C1L	71	P0DN25
LTEYEAGVCEDENWT	CRIM1	101	Q9NZV1
DVDIPTDFEGWFFCT	DEGS1	141	O15121
AETVEEFCRTWGDDY	CPPED1	136	Q9BRF8
CVGAELEYDSEHSDW	C20orf27	156	Q9GZN8
EVYYSGTWGTICDDE	MARCO	436	Q9UEW3
GYWVNEDGTACEDLD	LTBP2	1081	Q14767
DCVSYTESEQGLDYW	ERMARD	51	Q5T6L9
REDKCETDFYDVTWF	HRH1	176	P35367
SEADTEPCVDGWVYD	SLC22A11	106	Q9NSA0
RYEVDWNQSTFDCVD	SLC22A2	91	O15244
ESCLDGWEFSQDVYL	SLC22A4	111	Q9H015
ESCLDGWEFSQDVYL	SLC22A5	111	O76082
YDCFEAALGSEVRIW	IL17RC	231	Q8NAC3
DSGYIDCWDSERSDS	LIMCH1	176	Q9UPQ0
REFASDFEVGECWGY	TRIM37	361	O94972
DICSSEASWGDFEYD	PRUNE2	2341	Q8WUY3
FGDNGCIDDIWTRYD	HKDC1	711	Q2TB90
FSEENLEFWIACEDY	RGS5	86	O15539
VWDTREGTCVDTVYD	WDR17	636	Q8IZU2
GRDCRCGEEDEYFDW	SPSB3	91	Q6PJ21
EEEDGVWENGLSYEC	MED13	101	Q9UHV7
DEDWYLFCGDTVEIL	MRPL24	51	Q96A35
TNFEDVCDYLDWEVG	AMMECR1	221	Q9Y4X0
WAEADLYCSEFSVGR	CLEC19A	61	Q6UXS0
WREMEGDDCEFRYGD	URGCP	41	Q8TCY9
EYFLEACSREERDAW	PLEK2	81	Q9NYT0
WRVVCDSLEDYDTLG	TYRP1	286	P17643
AWERGFVSQYECDEI	NOD2	156	Q9HC29
SYIWELSDADCDGAL	REPS2	321	Q8NFH8
DVAVYFSREEWGCLR	ZNF747	41	Q9BV97
DFYRLCEASVWIDAA	SLC6A3	301	Q01959
RCSWEEAREYFEDNT	PRRG2	71	O14669
YGEDRRADFWCDVVI	SFMBT2	111	Q5VUG0
VEADTKYNDTDRCWG	TMEM104	186	Q8NE00
CADDSVYIWEIETGT	WDR72	576	Q3MJ13
EARCDWVIVAEDGYG	TLL2	916	Q9Y6L7
RWDTDEEGMAFCFEY	SNX27	476	Q96L92
FQDSPCEDEWESRFY	WIPF1	441	O43516
TDHWYKFDDGDVTEC	USP9Y	1896	O00507
EDADEIEYLVDGSWC	PIAS4	391	Q8N2W9
TWIGDKSFEYSDCEE	ZNF121	81	P58317
ELATWTPTEFRECDY	S100A3	41	P33764
AVWSEDGQCYEAEIE	SMNDC1	81	O75940
IEDWLQDCGYSEEGF	TESPA1	61	A2RU30
WREYQFCDGAVSDDL	ZMYM1	526	Q5SVZ6
SVDGLWYCFDDSDVQ	USP31	731	Q70CQ4
WYCFDDSDVQQLSED	USP31	736	Q70CQ4
FADVAVYFSPEEWEC	ZNF785	31	A8K8V0
GKRVCWEFATDDYDI	TMED8	201	Q6PL24
VSFADVAVYFCREEW	ZNF764	26	Q96H86
TFEDVAVYLSREEWG	ZNF34	36	Q8IZ26
EYEFDEQGHSTWLCR	SLC4A1AP	386	Q9BWU0
YLSERGSCFWVAESE	NAT8	101	Q9UHE5