Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	galactokinase activity	GALK1 GALK2	3.58e-05	2	120	2	GO:0004335
GeneOntologyMolecularFunction	GTPase binding	RASA1 MYO5A MYO5B RAPGEF4 IPO9 RPTOR MFN2 SGSM3 RIC1 EVI5L	6.41e-05	360	120	10	GO:0051020
GeneOntologyMolecularFunction	small GTPase binding	MYO5A MYO5B RAPGEF4 IPO9 RPTOR MFN2 SGSM3 RIC1 EVI5L	1.41e-04	321	120	9	GO:0031267
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC25A24 ATP6V1E1 TRPC1 SLC22A11 RYR3 KCNE4 SLC10A5 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A GABRA4	1.85e-04	758	120	14	GO:0015318
GeneOntologyMolecularFunction	kinase binding	FOXO3 PITPNM2 RARA RASA1 MYO5A CNKSR2 ACVRL1 MAP3K5 JAK2 MTOR RPTOR SCN5A CLTC LRP4 CDC6 TP53	2.26e-04	969	120	16	GO:0019900
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPC1 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A	2.30e-04	343	120	9	GO:0005261
GeneOntologyMolecularFunction	protein kinase binding	FOXO3 PITPNM2 RARA RASA1 MYO5A CNKSR2 ACVRL1 MAP3K5 JAK2 MTOR RPTOR SCN5A CLTC LRP4 TP53	2.36e-04	873	120	15	GO:0019901
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN5A SCN9A SCNN1A	2.69e-04	52	120	4	GO:0005272
GeneOntologyMolecularFunction	channel activity	TRPC1 CLDN2 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A GABRA4	3.28e-04	525	120	11	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPC1 CLDN2 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A GABRA4	3.34e-04	526	120	11	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPC1 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A GABRA4	4.56e-04	459	120	10	GO:0005216
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN5A SCN9A	4.97e-04	26	120	3	GO:0005248
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPC1 RYR3 KCNE4 SLC10A5 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A	5.04e-04	465	120	10	GO:0046873
GeneOntologyMolecularFunction	carboxylic acid binding	UBR1 RARA FOLR3 HLCS GSS GSTA3 GRIN3A	6.09e-04	239	120	7	GO:0031406
GeneOntologyMolecularFunction	glutathione peroxidase activity	GSTT2B GSTA3 GSTT2	6.21e-04	28	120	3	GO:0004602
GeneOntologyMolecularFunction	transporter activity	SLC25A24 PITPNM2 ATP6V1E1 TRPC1 SLC22A11 CLDN2 RYR3 KCNE4 SLC16A5 SLC10A5 SCN1A SCN5A SCN9A SCNN1A GM2A RIMBP2 GRIN3A GABRA4	6.82e-04	1289	120	18	GO:0005215
GeneOntologyMolecularFunction	glutathione transferase activity	GSTT2B GSTA3 GSTT2	6.90e-04	29	120	3	GO:0004364
GeneOntologyMolecularFunction	organic acid binding	UBR1 RARA FOLR3 HLCS GSS GSTA3 GRIN3A	8.71e-04	254	120	7	GO:0043177
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP6V1E1 TRPC1 RYR3 KCNE4 SLC10A5 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A	1.41e-03	627	120	11	GO:0022890
GeneOntologyMolecularFunction	microfilament motor activity	MYO5A MYO5B MYO1B	1.53e-03	38	120	3	GO:0000146
GeneOntologyMolecularFunction	disordered domain specific binding	MYO5A CLTC TP53	1.65e-03	39	120	3	GO:0097718
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A24 ATP6V1E1 TRPC1 SLC22A11 CLDN2 RYR3 KCNE4 SLC16A5 SLC10A5 SCN1A SCN5A SCN9A SCNN1A RIMBP2 GRIN3A GABRA4	1.87e-03	1180	120	16	GO:0022857
GeneOntologyMolecularFunction	potassium channel inhibitor activity	RASA1 KCNE4	1.90e-03	11	120	2	GO:0019870
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	FOXO3 UBR1 MYO5A TRPC1 DDI2 RYR3 MAP3K5 DDX11 JAK2 MTOR RPTOR TLR4 SCNN1A MFN2 CDC6 GNRHR TP53	1.50e-06	752	119	17	GO:1901699
GeneOntologyBiologicalProcess	actin filament-based movement	MYO5A MYO5B MYO1B CCDC88C KCNE4 SCN1A SCN5A SCN9A	2.98e-06	153	119	8	GO:0030048
GeneOntologyBiologicalProcess	regulation of pentose-phosphate shunt	MTOR RPTOR TP53	6.44e-06	7	119	3	GO:0043456
GeneOntologyBiologicalProcess	regulation of NADP metabolic process	MTOR RPTOR TP53	2.18e-05	10	119	3	GO:1902031
GeneOntologyBiologicalProcess	neuronal action potential	RAPGEF4 MTOR SCN1A SCN5A SCN9A	3.16e-05	63	119	5	GO:0019228
GeneOntologyBiologicalProcess	response to nitrogen compound	FOXO3 UBR1 MYO5A TRPC1 HLCS DDI2 TSC1 RYR3 MAP3K5 DDX11 JAK2 MTOR RPTOR TLR4 SCNN1A MFN2 HADHA CDC6 GNRHR TP53	3.83e-05	1272	119	20	GO:1901698
GeneOntologyBiologicalProcess	cellular response to L-leucine	UBR1 MTOR RPTOR	5.13e-05	13	119	3	GO:0071233
GeneOntologyBiologicalProcess	actin filament-based process	MKKS SHROOM3 ABI1 RASA1 MYO5A MYO5B MYO1B TSC1 JAK2 CCDC88C KCNE4 MTOR SCN1A SCN5A SCN9A MFN2	7.04e-05	912	119	16	GO:0030029
GeneOntologyBiologicalProcess	negative regulation of cell size	TSC1 MTOR MFN2	8.10e-05	15	119	3	GO:0045792
GeneOntologyBiologicalProcess	response to L-leucine	UBR1 MTOR RPTOR	9.93e-05	16	119	3	GO:0043201
GeneOntologyBiologicalProcess	cellular response to starvation	FOXO3 TSC1 MAP3K5 MTOR RPTOR GCN1 TP53	1.00e-04	185	119	7	GO:0009267
GeneOntologyBiologicalProcess	positive regulation of peptidyl-tyrosine phosphorylation	ABI1 RASA1 JAK2 MTOR TLR4 LRP4 TP53	1.30e-04	193	119	7	GO:0050731
GeneOntologyBiologicalProcess	positive regulation of pentose-phosphate shunt	MTOR RPTOR	1.97e-04	4	119	2	GO:1905857
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN5A SCN9A SCNN1A	2.05e-05	29	118	4	GO:0034706
GeneOntologyCellularComponent	monoatomic ion channel complex	CATSPERZ TRPC1 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A GRIN3A GABRA4	5.72e-05	378	118	10	GO:0034702
GeneOntologyCellularComponent	cation channel complex	CATSPERZ TRPC1 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A	5.73e-05	235	118	8	GO:0034703
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN5A SCN9A	1.13e-04	17	118	3	GO:0001518
GeneOntologyCellularComponent	transmembrane transporter complex	CATSPERZ ATP6V1E1 TRPC1 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A GRIN3A GABRA4	1.86e-04	523	118	11	GO:1902495
GeneOntologyCellularComponent	transporter complex	CATSPERZ ATP6V1E1 TRPC1 RYR3 KCNE4 SCN1A SCN5A SCN9A SCNN1A GRIN3A GABRA4	2.86e-04	550	118	11	GO:1990351
GeneOntologyCellularComponent	TORC1 complex	MTOR RPTOR	4.67e-04	6	118	2	GO:0031931
Domain	IQ	MYO5A MYO5B MYO1B SCN1A SCN5A SCN9A ASPM	7.94e-07	81	118	7	SM00015
Domain	IQ_motif_EF-hand-BS	MYO5A MYO5B MYO1B SCN1A SCN5A SCN9A ASPM	1.63e-06	90	118	7	IPR000048
Domain	IQ	MYO5A MYO5B MYO1B SCN1A SCN5A SCN9A ASPM	2.03e-06	93	118	7	PS50096
Domain	Na_trans_cytopl	SCN1A SCN5A SCN9A	4.85e-06	6	118	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN5A SCN9A	4.85e-06	6	118	3	IPR024583
Domain	IQ	MYO5A MYO5B MYO1B SCN1A SCN9A ASPM	5.73e-06	71	118	6	PF00612
Domain	ARM-type_fold	HEATR1 TRIP12 RYR3 PPP4R3B RIF1 IPO9 MTOR RPTOR CLTC ASPM GCN1	1.02e-05	339	118	11	IPR016024
Domain	Na_channel_asu	SCN1A SCN5A SCN9A	2.86e-05	10	118	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN5A SCN9A	2.86e-05	10	118	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN5A SCN9A	2.86e-05	10	118	3	PF06512
Domain	GALACTOKINASE	GALK1 GALK2	3.96e-05	2	118	2	PS00106
Domain	Galactokinase	GALK1 GALK2	3.96e-05	2	118	2	IPR000705
Domain	GalKase_gal_bdg	GALK1 GALK2	3.96e-05	2	118	2	PF10509
Domain	GalKase_gal-bd	GALK1 GALK2	3.96e-05	2	118	2	IPR019539
Domain	Galactokinase_CS	GALK1 GALK2	3.96e-05	2	118	2	IPR019741
Domain	ARM-like	HEATR1 TRIP12 PPP4R3B RIF1 IPO9 MTOR RPTOR ASPM GCN1	5.47e-05	270	118	9	IPR011989
Domain	-	HEATR1 TRIP12 RIF1 IPO9 MTOR RPTOR ASPM GCN1	8.38e-05	222	118	8	1.25.10.10
Domain	GHMP_KINASES_ATP	GALK1 GALK2	2.36e-04	4	118	2	PS00627
Domain	Mevalonate/galactokinase	GALK1 GALK2	2.36e-04	4	118	2	IPR006206
Domain	GHMP_knse_ATP-bd_CS	GALK1 GALK2	2.36e-04	4	118	2	IPR006203
Domain	GST_N	GSTT2B GSTA3 GSTT2	3.47e-04	22	118	3	PF02798
Domain	GST_NTER	GSTT2B GSTA3 GSTT2	3.47e-04	22	118	3	PS50404
Domain	GHMP_kinases_C	GALK1 GALK2	3.91e-04	5	118	2	PF08544
Domain	Myosin_S1_N	MYO5A MYO5B	3.91e-04	5	118	2	IPR008989
Domain	GHMP_kinase_C_dom	GALK1 GALK2	3.91e-04	5	118	2	IPR013750
Domain	GHMP_kinase_N_dom	GALK1 GALK2	3.91e-04	5	118	2	IPR006204
Domain	GHMP_kinases_N	GALK1 GALK2	3.91e-04	5	118	2	PF00288
Domain	-	GALK1 GALK2	3.91e-04	5	118	2	3.30.70.890
Domain	HEAT	HEATR1 MTOR RPTOR GCN1	4.94e-04	58	118	4	IPR000357
Domain	GST_C	GSTT2B GSTA3 GSTT2	5.75e-04	26	118	3	IPR004046
Domain	GST_C	GSTT2B GSTA3 GSTT2	5.75e-04	26	118	3	PF00043
Domain	Dilute_dom	MYO5A MYO5B	5.84e-04	6	118	2	IPR002710
Domain	DIL	MYO5A MYO5B	5.84e-04	6	118	2	PF01843
Domain	DILUTE	MYO5A MYO5B	5.84e-04	6	118	2	PS51126
Domain	DIL	MYO5A MYO5B	5.84e-04	6	118	2	SM01132
Domain	Glutathione_S-Trfase_N	GSTT2B GSTA3 GSTT2	6.44e-04	27	118	3	IPR004045
Domain	Ion_trans_dom	TRPC1 RYR3 SCN1A SCN5A SCN9A	7.84e-04	114	118	5	IPR005821
Domain	Ion_trans	TRPC1 RYR3 SCN1A SCN5A SCN9A	7.84e-04	114	118	5	PF00520
Domain	GST_CTER	GSTT2B GSTA3 GSTT2	1.28e-03	34	118	3	PS50405
Domain	Myosin_head_motor_dom	MYO5A MYO5B MYO1B	1.77e-03	38	118	3	IPR001609
Domain	MYOSIN_MOTOR	MYO5A MYO5B MYO1B	1.77e-03	38	118	3	PS51456
Domain	Myosin_head	MYO5A MYO5B MYO1B	1.77e-03	38	118	3	PF00063
Domain	MYSc	MYO5A MYO5B MYO1B	1.77e-03	38	118	3	SM00242
Domain	Glutathione-S-Trfase_C-like	GSTT2B GSTA3 GSTT2	1.90e-03	39	118	3	IPR010987
Domain	-	GSTT2B GSTA3 GSTT2	1.90e-03	39	118	3	1.20.1050.10
Domain	Znf_hrmn_rcpt	RARA NR5A1 NR1I3	3.06e-03	46	118	3	IPR001628
Domain	NUCLEAR_REC_DBD_2	RARA NR5A1 NR1I3	3.06e-03	46	118	3	PS51030
Domain	NUCLEAR_REC_DBD_1	RARA NR5A1 NR1I3	3.06e-03	46	118	3	PS00031
Domain	ZnF_C4	RARA NR5A1 NR1I3	3.06e-03	46	118	3	SM00399
Domain	zf-C4	RARA NR5A1 NR1I3	3.06e-03	46	118	3	PF00105
Domain	Nuclear_hrmn_rcpt	RARA NR5A1 NR1I3	3.06e-03	46	118	3	IPR001723
Domain	-	RARA NR5A1 NR1I3	3.26e-03	47	118	3	1.10.565.10
Domain	VitD_rcpt	NR5A1 NR1I3	3.43e-03	14	118	2	IPR000324
Domain	Nucl_hrmn_rcpt_lig-bd	RARA NR5A1 NR1I3	3.46e-03	48	118	3	IPR000536
Domain	HOLI	RARA NR5A1 NR1I3	3.46e-03	48	118	3	SM00430
Domain	Hormone_recep	RARA NR5A1 NR1I3	3.46e-03	48	118	3	PF00104
Domain	HEAT	HEATR1 RPTOR GCN1	3.46e-03	48	118	3	PF02985
Domain	-	RARA NR5A1 NR1I3	5.61e-03	57	118	3	3.30.50.10
Domain	Channel_four-helix_dom	SCN1A SCN5A SCN9A	5.61e-03	57	118	3	IPR027359
Domain	-	SCN1A SCN5A SCN9A	5.61e-03	57	118	3	1.20.120.350
Domain	Znf_NHR/GATA	RARA NR5A1 NR1I3	5.89e-03	58	118	3	IPR013088
Pathway	WP_TCELL_ACTIVATION_SARSCOV2	FOXO3 TSC1 JAK2 MTOR RPTOR TP53	3.31e-05	88	98	6	M42580
Pathway	WP_GLUTATHIONE_METABOLISM	GSTT2B GSS GSTA3 GSTT2	3.41e-05	27	98	4	MM15908
Pathway	KEGG_MEDICUS_REFERENCE_TSC1_2_MTORC1_SIGNALING_PATHWAY	TSC1 MTOR RPTOR	5.16e-05	11	98	3	M47915
Pathway	REACTOME_GLUTATHIONE_CONJUGATION	GSTT2B GSS GSTA3 GSTT2	1.09e-04	36	98	4	M1443
Pathway	REACTOME_GLUTATHIONE_CONJUGATION	GSTT2B GSS GSTA3 GSTT2	1.35e-04	38	98	4	MM14600
Pathway	WP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS	FOXO3 MTOR TP53	1.40e-04	15	98	3	M48306
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOXO3 PITPNM2 SHROOM3 NUP85 HECTD4 POLRMT INO80 MAP3K5 JAK2 CCDC88C SLC16A5 MTOR NAPRT RPTOR SCN5A XXYLT1 LRP4 MFN2 PDCD11 CABIN1 GCN1 RIC1 EVI5L	6.90e-12	1105	123	23	35748872
Pubmed	mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.	TSC1 MTOR RPTOR	4.32e-08	3	123	3	29215029
Pubmed	Network organization of the human autophagy system.	FOXO3 POLRMT TSC1 MAP3K5 NUP205 RIF1 MTOR RPTOR CLTC GEMIN4 HADHA GCN1	5.46e-08	437	123	12	20562859
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHROOM3 ABI1 MYO5A USP28 RAPGEF4 HECTD4 TSC1 CNKSR2 MAP3K5 CCDC88C MTOR RPTOR CLTC MFN2 RIMBP2 CABIN1 TNS1	5.48e-08	963	123	17	28671696
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	FOXO3 MYO5A MYO5B USP28 MTOR	6.77e-08	30	123	5	28077597
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYO5A POLRMT MYO1B HEATR1 TRIP12 NUP205 RIF1 MTOR CLTC GEMIN4 PDCD11 HADHA GCN1 TP53	8.68e-08	653	123	14	22586326
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN5A SCN9A SCNN1A	1.04e-07	13	123	4	15123669
Pubmed	Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy-Defective Mouse Liver.	MTOR RPTOR NR1I3	1.72e-07	4	123	3	31095752
Pubmed	Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.	TSC1 MTOR RPTOR	1.72e-07	4	123	3	26554817
Pubmed	Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.	MTOR RPTOR TP53	1.72e-07	4	123	3	19619545
Pubmed	Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.	TSC1 MTOR TP53	1.72e-07	4	123	3	17962806
Pubmed	mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.	TSC1 MTOR RPTOR	1.72e-07	4	123	3	21179166
Pubmed	The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.	TSC1 MTOR RPTOR	1.72e-07	4	123	3	32001717
Pubmed	Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.	TSC1 MTOR RPTOR	1.72e-07	4	123	3	23429704
Pubmed	Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma.	TSC1 MTOR TP53	1.72e-07	4	123	3	26683340
Pubmed	TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis.	TSC1 MTOR RPTOR	1.72e-07	4	123	3	31433805
Pubmed	Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.	TSC1 MTOR RPTOR	4.29e-07	5	123	3	29784808
Pubmed	Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.	TSC1 MTOR TP53	4.29e-07	5	123	3	14561707
Pubmed	mTORC1 promotes survival through translational control of Mcl-1.	TSC1 MTOR RPTOR	4.29e-07	5	123	3	18664580
Pubmed	FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition.	FOXO3 MTOR TP53	4.29e-07	5	123	3	27448972
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	NUP85 RBM33 HEATR1 NUP205 RIF1 IPO9 MTOR CLTC GEMIN4 PDCD11 HADHA GCN1 TP53	4.58e-07	638	123	13	33239621
Pubmed	Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.	FOXO3 TSC1 MTOR RPTOR NR5A1	4.96e-07	44	123	5	37494420
Pubmed	Mapping of unconventional myosins in mouse and human.	MYO5A MYO5B MYO1B OMP GSTA3	7.73e-07	48	123	5	8884266
Pubmed	Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.	TSC1 MTOR RPTOR	8.57e-07	6	123	3	24687132
Pubmed	mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.	TSC1 RPTOR MITF	8.57e-07	6	123	3	31527310
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	POLRMT MYO1B RIF1 CLTC PDCD11 HADHA CDC6 GCN1	1.29e-06	221	123	8	29991511
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 GALK1 MYO5A POLRMT MYO1B TSC1 HEATR1 TRIP12 NUP205 RIF1 IPO9 RPTOR CLTC ASPM GEMIN4 PDCD11 HADHA GCN1	1.36e-06	1353	123	18	29467282
Pubmed	The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.	TSC1 MTOR RPTOR	1.50e-06	7	123	3	19047368
Pubmed	Genome wide molecular analysis of minimally differentiated acute myeloid leukemia.	RASA1 JAK2 TP53	1.50e-06	7	123	3	19773259
Pubmed	Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3.	TSC1 RPTOR TP53	1.50e-06	7	123	3	31676673
Pubmed	Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.	MTOR RPTOR TP53	1.50e-06	7	123	3	35238644
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYO5A USP28 RAPGEF4 HECTD4 HLCS METTL26 TRIP12 RYR3 PPP4R3B ZNF197 CLTC LRP4 GM2A LRRN2 SGSM3 PBX3 CABIN1	2.97e-06	1285	123	17	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITPNM2 SHROOM3 USP28 HECTD4 INO80 HEPH NUP205 PPP4R3B RPTOR LRP4 PDCD11	3.02e-06	529	123	11	14621295
Pubmed	Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.	TSC1 MTOR RPTOR	3.57e-06	9	123	3	24948799
Pubmed	mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.	TSC1 MTOR TP53	3.57e-06	9	123	3	19620286
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN5A SCN9A	3.57e-06	9	123	3	16382098
Pubmed	FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.	FAAP24 FANCE RMI1	5.09e-06	10	123	3	20064461
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	ABI1 GALK1 POLRMT MYO1B IPO9 CLTC HADHA GCN1	5.98e-06	272	123	8	25315684
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO5A MYO1B TRIP12 MTOR CLTC GCN1 TP53	8.08e-06	202	123	7	33005030
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RBM33 USP28 MYO1B TSC1 DDX11 PPP4R3B RMI1 RPTOR CLTC ASPM TP53	8.21e-06	588	123	11	38580884
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXO3 ABI1 NUP85 USP28 POLRMT HEATR1 TRIP12 NUP205 TRAPPC13 RIF1 PBX3 CABIN1 TP53	1.15e-05	857	123	13	25609649
Pubmed	Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum.	TSC1 MTOR RPTOR	1.20e-05	13	123	3	35645731
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	TSC1 MTOR RPTOR	1.20e-05	13	123	3	25533187
Pubmed	FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.	FOXO3 MTOR	1.24e-05	2	123	2	24966026
Pubmed	Critical role for hypothalamic mTOR activity in energy balance.	TSC1 MTOR	1.24e-05	2	123	2	19356717
Pubmed	Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a.	FOXO3 TP53	1.24e-05	2	123	2	16757565
Pubmed	Apocynin inhibits Toll-like receptor-4-mediated activation of NF-κB by suppressing the Akt and mTOR pathways.	MTOR TLR4	1.24e-05	2	123	2	27590200
Pubmed	Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo.	MTOR TP53	1.24e-05	2	123	2	26577454
Pubmed	P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer.	TLR4 TP53	1.24e-05	2	123	2	38103365
Pubmed	YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway.	MTOR TLR4	1.24e-05	2	123	2	30372902
Pubmed	TSC/MTOR mutated renal cell carcinoma with leiomyomatous stroma is a distinct entity: a comprehensive study of 12 cases.	TSC1 MTOR	1.24e-05	2	123	2	36592877
Pubmed	Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.	MTOR TP53	1.24e-05	2	123	2	31707831
Pubmed	p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.	CDC6 TP53	1.24e-05	2	123	2	16055707
Pubmed	Modulation of Janus kinase 2 by p53 in ovarian cancer cells.	JAK2 TP53	1.24e-05	2	123	2	15358195
Pubmed	The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner.	MAP3K5 TLR4	1.24e-05	2	123	2	15843568
Pubmed	Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system.	LRRN1 LRRN2	1.24e-05	2	123	2	8717337
Pubmed	Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.	FOXO3 TP53	1.24e-05	2	123	2	18824006
Pubmed	Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways.	MTOR TLR4	1.24e-05	2	123	2	29763880
Pubmed	The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53.	PBX3 TP53	1.24e-05	2	123	2	33526870
Pubmed	An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.	FOXO3 TP53	1.24e-05	2	123	2	22761954
Pubmed	Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.	TSC1 MTOR	1.24e-05	2	123	2	26991739
Pubmed	Mammalian class theta GST and differential susceptibility to carcinogens: a review.	GSTT2B GSTT2	1.24e-05	2	123	2	11018744
Pubmed	Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1.	GSTT2B GSTT2	1.24e-05	2	123	2	8617493
Pubmed	Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.	TSC1 RPTOR	1.24e-05	2	123	2	27004103
Pubmed	Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.	MTOR RPTOR	1.24e-05	2	123	2	27018708
Pubmed	Tsc1 expression by dendritic cells is required to preserve T-cell homeostasis and response.	TSC1 RPTOR	1.24e-05	2	123	2	28079897
Pubmed	mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.	TSC1 MTOR	1.24e-05	2	123	2	19934433
Pubmed	Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.	MTOR TP53	1.24e-05	2	123	2	28464864
Pubmed	MYO5A Gene Is a Target of MITF in Melanocytes.	MYO5A MITF	1.24e-05	2	123	2	27939378
Pubmed	TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth.	TLR4 TP53	1.24e-05	2	123	2	26063617
Pubmed	The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.	FOXO3 TP53	1.24e-05	2	123	2	21423206
Pubmed	Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5.	SCN5A SCN9A	1.24e-05	2	123	2	26861708
Pubmed	Mutant white mice; a new dominant autosomal mutant affecting coat color in Mus musculus.	MYO5A MITF	1.24e-05	2	123	2	18902556
Pubmed	The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis.	TSC1 TP53	1.24e-05	2	123	2	31088907
Pubmed	TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia.	FOXO3 TLR4	1.24e-05	2	123	2	30523761
Pubmed	Regulation of clathrin-mediated endocytosis by p53.	CLTC TP53	1.24e-05	2	123	2	18363968
Pubmed	Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.	TSC1 MTOR	1.24e-05	2	123	2	15185396
Pubmed	The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function.	MTOR TP53	1.24e-05	2	123	2	23734707
Pubmed	Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.	JAK2 TP53	1.24e-05	2	123	2	28557976
Pubmed	mTORC1 Activation Promotes Spermatogonial Differentiation and Causes Subfertility in Mice.	TSC1 MTOR	1.24e-05	2	123	2	27605345
Pubmed	Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.	MTOR RPTOR	1.24e-05	2	123	2	17301289
Pubmed	Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.	SCN1A SCN5A	1.24e-05	2	123	2	16054936
Pubmed	Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.	GSTT2B GSTT2	1.24e-05	2	123	2	12038961
Pubmed	Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling.	TSC1 MTOR	1.24e-05	2	123	2	21268018
Pubmed	Critical roles for the TSC-mTOR pathway in β-cell function.	TSC1 MTOR	1.24e-05	2	123	2	19690069
Pubmed	Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status.	MTOR TP53	1.24e-05	2	123	2	20811722
Pubmed	Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.	MTOR RPTOR	1.24e-05	2	123	2	32687428
Pubmed	Monomeric but not trimeric clathrin heavy chain regulates p53-mediated transcription.	CLTC TP53	1.24e-05	2	123	2	17952123
Pubmed	Pro-Apoptotic Activity of Ruxolitinib Alone and in Combination with Hydroxyurea, Busulphan, and PI3K/mTOR Inhibitors in JAK2-Positive Human Cell Lines.	JAK2 MTOR	1.24e-05	2	123	2	25931349
Pubmed	TSC/MTOR -associated Eosinophilic Renal Tumors Exhibit a Heterogeneous Clinicopathologic Spectrum : Several Distinct Entities or a Tumor Family?	TSC1 MTOR	1.24e-05	2	123	2	36727758
Pubmed	Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status.	JAK2 TP53	1.24e-05	2	123	2	28744014
Pubmed	Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2.	GALK1 GALK2	1.24e-05	2	123	2	7542884
Pubmed	Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.	FOXO3 TP53	1.24e-05	2	123	2	15604409
Pubmed	Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway.	FOXO3 TP53	1.24e-05	2	123	2	28046000
Pubmed	Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.	JAK2 TP53	1.24e-05	2	123	2	25516983
Pubmed	Identification of a function-specific mutation of clathrin heavy chain (CHC) required for p53 transactivation.	CLTC TP53	1.24e-05	2	123	2	19766654
Pubmed	The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.	MTOR RPTOR	1.24e-05	2	123	2	30202948
Pubmed	Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.	ACVRL1 JAK2	1.24e-05	2	123	2	34702814
Pubmed	DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence.	MTOR TP53	1.24e-05	2	123	2	21212465
Pubmed	Cabin1 restrains p53 activity on chromatin.	CABIN1 TP53	1.24e-05	2	123	2	19668210
Interaction	TOP3B interactions	FOXO3 PITPNM2 SHROOM3 NUP85 RBM33 HECTD4 POLRMT MYO1B INO80 MAP3K5 JAK2 CCDC88C RMI1 SLC16A5 MTOR NAPRT RPTOR SCN5A XXYLT1 LRP4 MFN2 PDCD11 HADHA CABIN1 GCN1 RIC1 TP53 EVI5L	2.31e-08	1470	119	28	int:TOP3B
Interaction	FOXG1 interactions	FOXO3 RBM33 TSC1 HEATR1 NUP205 RIF1 TP53	1.51e-06	95	119	7	int:FOXG1
Interaction	COMTD1 interactions	NUP85 USP28 HEATR1 NUP205 PPP4R3B IPO9 MTOR GEMIN4 GCN1	2.94e-06	200	119	9	int:COMTD1
Interaction	TNFSF13B interactions	NUP85 HEATR1 MAP3K5 IPO9 MTOR GEMIN4 GCN1	6.80e-06	119	119	7	int:TNFSF13B
Interaction	FTH1 interactions	UBR1 CAPNS2 TSC1 PRPS1L1 GM2A HADHA NR1I3 TP53	9.13e-06	174	119	8	int:FTH1
Interaction	P2RY8 interactions	PEX3 HEATR1 NUP205 RIF1 MTOR GEMIN4 GCN1 EVI5L	1.12e-05	179	119	8	int:P2RY8
Interaction	HIF1A interactions	FOXO3 USP28 POLRMT MYO1B HEATR1 MTOR RPTOR ZNF197 MITF CDC6 GCN1 TP53	1.19e-05	441	119	12	int:HIF1A
Interaction	TERT interactions	FOXO3 FAAP24 STEAP4 MAP3K5 MTOR TP53	5.10e-05	111	119	6	int:TERT
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN5A SCN9A	6.37e-06	9	78	3	1203
GeneFamily	Myosins, class V	MYO5A MYO5B	5.50e-05	3	78	2	1100
GeneFamily	MTOR complex 1\|MTOR complex 2	MTOR RPTOR	1.10e-04	4	78	2	1332
GeneFamily	Glutathione S-transferases	GSTT2B GSTA3 GSTT2	1.66e-04	25	78	3	567
GeneFamily	Nuclear hormone receptors	RARA NR5A1 NR1I3	1.23e-03	49	78	3	71
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	HEATR1 GEMIN4 PDCD11	1.39e-03	51	78	3	870
GeneFamily	DNA helicases	INO80 DDX11	2.40e-03	17	78	2	1167
Coexpression	YOSHIMURA_MAPK8_TARGETS_UP	RARA MYO5B RBMS2 RAPGEF4 MYO1B CNKSR2 OMP GSS JAK2 CCDC88C GSTT2 TLR4 SCN9A SCNN1A GEMIN4 NR5A1 HADHA GRIN3A DNAAF1 CABIN1 GNRHR	4.57e-07	1281	122	21	M1884
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MACC1 MYO5B RAPGEF4 DNAH7 SCN9A SCNN1A RIMBP2	1.08e-06	192	123	7	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RMI1 SLC16A5 FAM157C MITF FAM157B RIC1	5.55e-06	160	123	6	70f3637dd0bcfcef421aa114f946fff0048f192e
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 MYO5B MYO1B DENND3 SCNN1A TNS1	1.23e-05	184	123	6	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 MYO5B MYO1B DENND3 SCNN1A TNS1	1.23e-05	184	123	6	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5B RENBP DENND3 RYR3 UBXN11 SCN5A	1.27e-05	185	123	6	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATSPERZ UBR1 STEAP4 MYO1B KCNE4 EVI5L	1.31e-05	186	123	6	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 TRPC1 MYO1B GSTA3 LRRN2 TNS1	1.31e-05	186	123	6	ca5e9c6531cb5d199e27509bfab1d62e3937177e
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 TRPC1 MYO1B GSTA3 LRRN2 TNS1	1.31e-05	186	123	6	1ed71b229f40a680071b14f5a7a19706e0fd14b1
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATSPERZ UBR1 STEAP4 MYO1B KCNE4 EVI5L	1.31e-05	186	123	6	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	SHROOM3 MYO5B STEAP4 MYO1B SCN1A SCNN1A	1.39e-05	188	123	6	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 MYO5A MYO1B CCDC88C SLC16A5 RIMBP2	1.43e-05	189	123	6	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 MACC1 DNAH7 SLC16A5 SCNN1A RIMBP2	1.52e-05	191	123	6	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 MACC1 DNAH7 SLC16A5 SCNN1A RIMBP2	1.52e-05	191	123	6	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	droplet-Lung-nan-18m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 MYO1B GSTA3 KCNE4 LRP4 TNS1	1.57e-05	192	123	6	df56c3e3bb1aafc1126607f4426554c09c8c40cf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PITPNM2 TPST1 MACC1 DNAH7 SLC16A5 SCNN1A	1.62e-05	193	123	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 STEAP4 DNAH7 GSTA3 SCN1A DNAAF1	1.62e-05	193	123	6	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PITPNM2 TPST1 MACC1 DNAH7 SLC16A5 SCNN1A	1.62e-05	193	123	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 MYO5B STEAP4 MYO1B SCN1A SCNN1A	1.66e-05	194	123	6	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 SHROOM3 MYO5B DNAH7 MITF SCNN1A	1.66e-05	194	123	6	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 SHROOM3 MYO5B DNAH7 MITF SCNN1A	1.66e-05	194	123	6	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MACC1 MYO5B RAPGEF4 SCN9A SCNN1A RIMBP2	1.66e-05	194	123	6	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 SHROOM3 MYO5B DNAH7 MITF SCNN1A	1.76e-05	196	123	6	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MACC1 ATP6V1E1 FOLR3 ACVRL1 FRMD4A GM2A	1.76e-05	196	123	6	5ed7f063fc4ba213fe15256caf77f59c9e476290
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MACC1 SHROOM3 MYO5A MYO5B CLDN2 RIMBP2	1.81e-05	197	123	6	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	BAL-Control-cDC_0\|Control / Compartment, Disease Groups and Clusters	FOLR3 FRMD4A UBXN11 TLR4 MITF GNS	1.92e-05	199	123	6	4518ffa51ead9da1ddf07bf048b18602e50f0f84
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	DNAH7 CLDN2 MITF LRRN2 DNAAF1 GNS	1.97e-05	200	123	6	5fb90118d3abc28d72bc483e68317255090a04c7
ToppCell	droplet-Liver-LIVER_HEP-30m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MKKS DDI2 METTL26 GSTA3 GSTT2	6.07e-05	150	123	5	954ca50b36dadaab625ab011aedbf550de2e566f
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	MACC1 SHROOM3 CCDC88C CDC6 GCN1	7.99e-05	159	123	5	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF4 HEPH FRMD4A KCNE4 GRIN3A	8.48e-05	161	123	5	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1B MAP3K5 FRMD4A KCNE4 GRIN3A	9.25e-05	164	123	5	f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Pvalb_(Non-anterior_nuclei)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CATSPERZ GPR63 KCNE4 SCNN1A	9.93e-05	87	123	4	fd0df79b02f96463a6bad90dcd019c59c8e3eb0e
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CNKSR2 GSS GSTA3 ASPM SCNN1A	1.01e-04	167	123	5	a90f905ef38437752e2b0b71bd0322a184de1861
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	RASA1 RYR3 FAM157C MITF NR1I3	1.04e-04	168	123	5	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	Control\|World / group, cell type (main and fine annotations)	SHROOM3 MYO5B STEAP4 MYO1B SCN1A	1.04e-04	168	123	5	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	CV-Mild-7\|CV / Virus stimulation, Condition and Cluster	PEX3 MYO1B HEATR1 NUP205 CABIN1	1.09e-04	170	123	5	25ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LRRN1 SLC10A5 ASPM NEIL3 CDC6	1.19e-04	173	123	5	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	PEX3 MYO1B HEATR1 NUP205 CABIN1	1.19e-04	173	123	5	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LRRN1 SLC10A5 ASPM NEIL3 CDC6	1.19e-04	173	123	5	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DDX11 GM2A NEIL3 CDC6 CDCA7L	1.22e-04	174	123	5	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYO5A FRMD4A TLR4 GM2A GRIN3A	1.22e-04	174	123	5	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	SHROOM3 MYO5B MYO1B DENND3 TNS1	1.22e-04	174	123	5	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATSPERZ STEAP4 MYO1B KCNE4 SCN9A	1.25e-04	175	123	5	bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CATSPERZ STEAP4 MYO1B KCNE4 SCN9A	1.25e-04	175	123	5	c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MYO5B DENND3 MAP3K5 SCNN1A	1.32e-04	177	123	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	MACC1 SHROOM3 MYO5B MYO1B SCNN1A	1.39e-04	179	123	5	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NUP205 DDX11 NEIL3 CDC6 TP53	1.39e-04	179	123	5	df4d0b2fe47d2c7def729b3217cb01ced01495ff
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 SHROOM3 MYO5B DENND3 SCNN1A	1.39e-04	179	123	5	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PITPNM2 ROBO4 RBMS2 RAPGEF4 ACVRL1	1.43e-04	180	123	5	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 MACC1 MYO1B GSTA3 CCDC88C	1.43e-04	180	123	5	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	Endothelial-A-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 RAPGEF4 ACVRL1 HEPH DDX11	1.43e-04	180	123	5	4c3376169770ee9f9283daae44c17f35e46bfd19
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MYO5B MYO1B DENND3 SCNN1A	1.47e-04	181	123	5	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 RAPGEF4 MYO1B PDCD11 SGSM3	1.47e-04	181	123	5	709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A ASPM	1.54e-04	183	123	5	04d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR1 STEAP4 MYO1B KCNE4 RIMBP2	1.54e-04	183	123	5	0f02136359787bd78146617990968baa47a65d86
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	STEAP4 MYO1B DENND3 KCNE4 GRIN3A	1.54e-04	183	123	5	273db6a3b00a93ca852498471187b642b5368185
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR1 STEAP4 MYO1B KCNE4 RIMBP2	1.54e-04	183	123	5	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 ROBO4 STEAP4 JAK2 CLTC	1.58e-04	184	123	5	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	droplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 MYO1B GSTA3 LRP4 TNS1	1.58e-04	184	123	5	89ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MACC1 SHROOM3 MYO5B DENND3 SCNN1A	1.58e-04	184	123	5	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 MYO1B GSTA3 LRP4 TNS1	1.58e-04	184	123	5	4df6027fa635996c1eddb920f88a5265772df1cd
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	SHROOM3 MYO5B MYO1B DENND3 SCNN1A	1.58e-04	184	123	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B MYO1B MITF SCN9A GRIN3A	1.67e-04	186	123	5	948815663c212c4311329d503b5991cbbbff9808
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 MYO1B SCNN1A LRRN2 RIMBP2	1.67e-04	186	123	5	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHROOM3 MYO5B STEAP4 MYO1B SCNN1A	1.67e-04	186	123	5	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 DNAH7 LRRN2 PBX3 TNS1	1.67e-04	186	123	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHROOM3 MYO5B STEAP4 MYO1B SCNN1A	1.67e-04	186	123	5	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B MYO1B EYS MITF ASPM	1.67e-04	186	123	5	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A ASPM	1.71e-04	187	123	5	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 DNAH7 LRRN2 PBX3 TNS1	1.71e-04	187	123	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 SHROOM3 MYO5B MAP3K5 SCNN1A	1.71e-04	187	123	5	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	SHROOM3 MYO5B MYO1B DENND3 SCNN1A	1.71e-04	187	123	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 MYO5A MYO1B CCDC88C RIMBP2	1.71e-04	187	123	5	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MACC1 SHROOM3 MYO5B MYO1B DENND3	1.75e-04	188	123	5	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	Entopeduncular-Endothelial\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SLC25A24 RBMS2 MYO1B ACVRL1 TNS1	1.75e-04	188	123	5	94774652fd42bad5012356672ffac8b6d2c22d37
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_bronchial_(8)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PITPNM2 ROBO4 RAPGEF4 ACVRL1 DENND3	1.75e-04	188	123	5	986aaf31161ec3d1e6c76ee2dd17f44848a21f7e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A ASPM	1.75e-04	188	123	5	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 MYO1B MITF LRRN2 RIMBP2	1.75e-04	188	123	5	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B MYO1B MITF SCN9A GRIN3A	1.80e-04	189	123	5	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 ROBO4 RAPGEF4 ACVRL1 SCN9A	1.80e-04	189	123	5	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 SHROOM3 MYO5A CCDC88C SLC16A5	1.80e-04	189	123	5	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_bronchial_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PITPNM2 ROBO4 RAPGEF4 ACVRL1 DENND3	1.80e-04	189	123	5	033a2be8bbb7bfb437e6f1657b6ca02070c74aa8
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1B GSTA3 KCNE4 LRP4 TNS1	1.80e-04	189	123	5	e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A GRIN3A	1.84e-04	190	123	5	d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 SHROOM3 SLC16A5 SCNN1A RIMBP2	1.84e-04	190	123	5	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 SHROOM3 SLC16A5 SCNN1A RIMBP2	1.84e-04	190	123	5	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 DNAH7 SLC16A5 SCNN1A RIMBP2	1.84e-04	190	123	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 MYO5B MYO1B DENND3 TNS1	1.84e-04	190	123	5	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 MACC1 MYO5A MYO1B RIMBP2	1.84e-04	190	123	5	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 ROBO4 RAPGEF4 ACVRL1 SCN9A	1.84e-04	190	123	5	a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A ASPM	1.84e-04	190	123	5	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	droplet-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO1B GSTA3 KCNE4 LRP4 TNS1	1.84e-04	190	123	5	0b7200897b2c389632c9b1ee37e272b811555dbc
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A ASPM	1.84e-04	190	123	5	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DDX11 IPO9 CRLF3 ASPM PBX3	1.84e-04	190	123	5	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B EYS MITF SCN9A ASPM	1.84e-04	190	123	5	e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SHROOM3 MYO1B GSTA3 LRP4 TNS1	1.88e-04	191	123	5	509230f50568e5a8ecf08edc4d58f9e2aa96efe9
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SHROOM3 MYO1B GSTA3 LRP4 TNS1	1.88e-04	191	123	5	36467322096bc766cd777dae3bfb4e65511e492c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM3 MYO1B GSTA3 LRP4 TNS1	1.88e-04	191	123	5	a261f0738d974784bbdd60f23092bfbcca464459
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	SHROOM3 MYO5B STEAP4 MYO1B SCNN1A	1.88e-04	191	123	5	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MACC1 MYO5B DNAH7 MITF SCN9A	1.88e-04	191	123	5	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MACC1 MYO5B MITF SCN9A SCNN1A	1.88e-04	191	123	5	05731ece7867659c662f952812805f947032fe10
Drug	Colistin sulfate [1264-72-8]; Up 200; 3uM; MCF7; HT_HG-U133A	RARA PEX3 MYO1B GSTA3 FRMD4A RIF1 IPO9 MTOR MITF	1.06e-06	196	121	9	2851_UP
Drug	AMPK inhibitor	FOXO3 UBR1 TSC1 MTOR RPTOR TP53	8.06e-06	89	121	6	CID011524144
Drug	Trichlorfon [52-68-6]; Down 200; 15.6uM; HL60; HT_HG-U133A	FAAP24 GPR63 HIPK3 CCDC88C ZNF197 MFN2 GM2A SGSM3	1.10e-05	198	121	8	1839_DN
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; PC3; HT_HG-U133A	GALK1 GALK2 HLCS HIPK3 CCDC88C GM2A CABIN1 CSTF2T	1.10e-05	198	121	8	6657_DN
Drug	erlotinib	ABI1 RASA1 RIF1 MTOR CLTC LRRN2 TP53	1.79e-05	153	121	7	CID000176870
Drug	AC1NPPZW	ABI1 TRPC1 MTOR SCN5A SCN9A SCNN1A	1.87e-05	103	121	6	CID005183170
Drug	vitamin E	TPST1 RARA POLRMT STEAP4 GSS GSTA3 GSTT2 EYS MTOR MITF LRP4	2.40e-05	441	121	11	CID000002116
Drug	Ranolazine	SCN5A SCN9A	2.80e-05	2	121	2	DB00243
Drug	Phenytoin	SCN1A SCN5A	2.80e-05	2	121	2	DB00252
Drug	bityrosine	ROBO4 TPST1 RENBP GCN1 TP53	5.68e-05	77	121	5	CID000107904
Drug	Sodium Cholate	RARA TLR4 NR1I3 TP53	5.98e-05	40	121	4	ctd:D020358
Drug	UDP-galactosamine	GALK1 GALK2 GNS	6.36e-05	15	121	3	CID000161225
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; PC3; HT_HG-U133A	HLCS HIPK3 GM2A SGSM3 CDC6 TNS1 CSTF2T	7.63e-05	192	121	7	6664_DN
Drug	QX-314	TRPC1 SCN5A SCN9A SCNN1A GABRA4	7.68e-05	82	121	5	CID000003925
Drug	Epitiostanol [2363-58-8]; Up 200; 13uM; MCF7; HT_HG-U133A	ROBO4 RARA JAK2 SLC16A5 TNS1 GNS CSTF2T	7.89e-05	193	121	7	4788_UP
Drug	rapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; PC3; HT_HG-U133A	GALK2 HLCS MYO1B DENND3 LRRN2 TNS1 GNS	7.89e-05	193	121	7	5932_UP
Drug	Halcinonide [3093-35-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	TRPC1 HEPH GSTA3 JAK2 SCNN1A TNS1 TP53	8.15e-05	194	121	7	3680_UP
Drug	Phenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; MCF7; HT_HG-U133A	RARA MYO1B MAP3K5 MITF MFN2 PDCD11 NEIL3	8.41e-05	195	121	7	6234_DN
Drug	Chlorthalidone [77-36-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	GALK2 TRPC1 HLCS CCDC88C MITF GM2A SGSM3	8.41e-05	195	121	7	7152_DN
Drug	Tiabendazole [148-79-8]; Up 200; 19.8uM; MCF7; HT_HG-U133A	RARA HLCS GPR63 DENND3 JAK2 RIF1 SCNN1A	8.41e-05	195	121	7	4402_UP
Drug	Mebeverine hydrochloride [2753-45-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	RARA HLCS HIPK3 PPP4R3B CCDC88C GM2A DNAAF1	8.41e-05	195	121	7	6795_DN
Drug	chloroethyl	MYO5A MYO5B HEPH PRPS1L1 TP53	8.61e-05	84	121	5	CID000006338
Drug	Fluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; PC3; HT_HG-U133A	GALK1 RARA HLCS MAP3K5 JAK2 GM2A CABIN1	8.69e-05	196	121	7	5741_DN
Drug	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	FOXO3 RARA TLR4 TP53	8.74e-05	44	121	4	ctd:C419410
Drug	4-hydroxy-2-nonenal	FOXO3 RARA NUP85 TSC1 GSS GSTA3 JAK2 MTOR TLR4 MITF ASPM NEIL3 NR1I3 TP53	8.88e-05	798	121	14	ctd:C027576
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	GPR63 DENND3 HEPH HIPK3 MITF GM2A GNRHR	8.97e-05	197	121	7	5411_UP
Drug	Nicardipine hydrochloride [54527-84-3]; Up 200; 7.8uM; MCF7; HT_HG-U133A	TRPC1 HLCS FRMD4A SLC16A5 SCNN1A RIMBP2 TNS1	9.26e-05	198	121	7	3215_UP
Drug	Naringin hydrate [11032-30-7]; Down 200; 6.6uM; PC3; HT_HG-U133A	DENND3 FANCE PPP4R3B GEMIN4 PDCD11 SGSM3 CSTF2T	9.26e-05	198	121	7	4605_DN
Drug	Adrenosterone [382-45-6]; Up 200; 13.4uM; HL60; HT_HG-U133A	RARA RBMS2 HLCS CNKSR2 RIF1 KCNE4 SLC16A5	9.26e-05	198	121	7	3107_UP
Drug	Acetazolamide [59-66-5]; Down 200; 18uM; HL60; HT_HG-U133A	GPR63 HIPK3 FANCE ZNF197 MFN2 GM2A CSTF2T	9.26e-05	198	121	7	1850_DN
Drug	Zonisamide	SCN1A SCN5A SCN9A	9.43e-05	17	121	3	DB00909
Drug	phosalone	RARA NR1I3 TP53	9.43e-05	17	121	3	ctd:C003117
Drug	Isometheptene mucate; Up 200; 8.2uM; MCF7; HT_HG-U133A	FAAP24 HLCS CNKSR2 GSTA3 HIPK3 ZNF197 CABIN1	9.55e-05	199	121	7	6524_UP
Drug	Androstenedione	GSTA3 MTOR NR5A1 NR1I3	9.55e-05	45	121	4	ctd:D000735
Drug	Ricinine [524-40-3]; Down 200; 24.4uM; MCF7; HT_HG-U133A	GALK2 FAAP24 MAP3K5 JAK2 MTOR GM2A DNAAF1	9.85e-05	200	121	7	6206_DN
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN5A SCN9A	7.52e-06	10	119	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN5A SCN9A	7.52e-06	10	119	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN5A SCN9A	1.37e-05	12	119	3	DOID:0060170 (implicated_via_orthology)
Disease	Early Infantile Epileptic Encephalopathy 6	SCN1A SCN9A	1.61e-05	2	119	2	C4551549
Disease	Charcot-Marie-Tooth disease (biomarker_via_orthology)	GSTT2B GSTT2	1.61e-05	2	119	2	DOID:10595 (biomarker_via_orthology)
Disease	Focal Cortical Dysplasia of Taylor, Type IIb	TSC1 MTOR	4.83e-05	3	119	2	C1846389
Disease	FOCAL CORTICAL DYSPLASIA OF TAYLOR	TSC1 MTOR	4.83e-05	3	119	2	C1846385
Disease	Focal Cortical Dysplasia of Taylor, Type IIa	TSC1 MTOR	4.83e-05	3	119	2	C1846386
Disease	Isolated focal cortical dysplasia type II	TSC1 MTOR	4.83e-05	3	119	2	cv:C1846385
Disease	FOCAL CORTICAL DYSPLASIA, TYPE II	TSC1 MTOR	4.83e-05	3	119	2	607341
Disease	carotid stenosis (implicated_via_orthology)	TLR4 MFN2	1.60e-04	5	119	2	DOID:13001 (implicated_via_orthology)
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK2 TP53	3.34e-04	7	119	2	DOID:14566 (implicated_via_orthology)
Disease	Uterine Cervical Neoplasm	JAK2 MTOR TP53	3.81e-04	35	119	3	C0007873
Disease	Early Childhood Epilepsy, Myoclonic	SCN1A SCN9A	4.44e-04	8	119	2	C0393695
Disease	low tension glaucoma (is_implicated_in)	TLR4 TP53	4.44e-04	8	119	2	DOID:13544 (is_implicated_in)
Disease	Idiopathic Myoclonic Epilepsy	SCN1A SCN9A	4.44e-04	8	119	2	C0338478
Disease	Symptomatic Myoclonic Epilepsy	SCN1A SCN9A	4.44e-04	8	119	2	C0338479
Disease	Benign Infantile Myoclonic Epilepsy	SCN1A SCN9A	4.44e-04	8	119	2	C0751120
Disease	Myoclonic Encephalopathy	SCN1A SCN9A	4.44e-04	8	119	2	C0438414
Disease	Myoclonic Absence Epilepsy	SCN1A SCN9A	4.44e-04	8	119	2	C0393703
Disease	Adult Hepatocellular Carcinoma	TSC1 TP53	5.70e-04	9	119	2	C0279607
Disease	Myoclonic Epilepsy	SCN1A SCN9A	5.70e-04	9	119	2	C0014550
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN9A	5.70e-04	9	119	2	C3502809
Disease	Carcinoma, Small Cell	MTOR TP53	5.70e-04	9	119	2	C0262584
Disease	Epilepsy, Myoclonic, Infantile	SCN1A SCN9A	7.11e-04	10	119	2	C0917800
Disease	Adrenal Gland Neoplasms	GNRHR TP53	8.66e-04	11	119	2	C0001624
Disease	Adrenal Cancer	GNRHR TP53	8.66e-04	11	119	2	C0750887
Disease	endometrial adenocarcinoma (is_marker_for)	FOXO3 TP53	8.66e-04	11	119	2	DOID:2870 (is_marker_for)
Disease	Myoclonic Astatic Epilepsy	SCN1A SCN9A	8.66e-04	11	119	2	C0393702
Disease	C-X-C motif chemokine 10 measurement	SHROOM3 GALK2 HECTD4 GNRHR	1.01e-03	109	119	4	EFO_0008056
Disease	basal cell carcinoma (is_implicated_in)	RASA1 TP53	1.04e-03	12	119	2	DOID:2513 (is_implicated_in)
Disease	Thrombocythemia, Essential	JAK2 TP53	1.04e-03	12	119	2	C0040028
Disease	Myeloproliferative disease	JAK2 TP53	1.04e-03	12	119	2	C0027022
Disease	Ciliopathies	MKKS TSC1 SCNN1A DNAAF1	1.04e-03	110	119	4	C4277690
Disease	Hypertensive disease	GSTT2 MTOR TLR4 SCNN1A TP53	1.06e-03	190	119	5	C0020538
Disease	Liver carcinoma	RARA TSC1 MTOR TLR4 ASPM NEIL3 CDC6 TP53	1.07e-03	507	119	8	C2239176
Disease	serum gamma-glutamyl transferase measurement	FOXO3 UBR1 HECTD4 MYO1B GSTT2B RMI1 EYS CABIN1 GCN1 CDCA7L NR1I3	1.20e-03	914	119	11	EFO_0004532
Disease	3-formylindole measurement	GSTT2B GSTT2	1.22e-03	13	119	2	EFO_0801025
Disease	xanthine measurement	CNKSR2 EYS	1.22e-03	13	119	2	EFO_0010548
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN9A	1.22e-03	13	119	2	C0751122
Disease	Adenocarcinoma Of Esophagus	TLR4 TP53	1.42e-03	14	119	2	C0279628
Disease	vascular dementia (biomarker_via_orthology)	MTOR TP53	1.42e-03	14	119	2	DOID:8725 (biomarker_via_orthology)
Disease	acute graft vs. host disease, donor genotype effect measurement	SLC25A24 EYS	1.64e-03	15	119	2	EFO_0004599, EFO_0007892
Disease	Neoplasm of uncertain or unknown behavior of bladder	TSC1 MTOR	1.64e-03	15	119	2	C0496930
Disease	Benign neoplasm of bladder	TSC1 MTOR	1.64e-03	15	119	2	C0154017
Disease	Carcinoma in situ of bladder	TSC1 MTOR	1.64e-03	15	119	2	C0154091
Disease	Sarcomatoid Renal Cell Carcinoma	TSC1 MTOR MITF TP53	1.83e-03	128	119	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	TSC1 MTOR MITF TP53	1.83e-03	128	119	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	TSC1 MTOR MITF TP53	1.83e-03	128	119	4	C1266044
Disease	Papillary Renal Cell Carcinoma	TSC1 MTOR MITF TP53	1.83e-03	128	119	4	C1306837
Disease	Renal Cell Carcinoma	TSC1 MTOR MITF TP53	1.83e-03	128	119	4	C0007134
Disease	teratocarcinoma-derived growth factor 1 measurement	MYO5A TNS1	1.87e-03	16	119	2	EFO_0008297
Disease	cholesteatoma of middle ear (is_marker_for)	TLR4 TP53	1.87e-03	16	119	2	DOID:10964 (is_marker_for)
Disease	response to hydrochlorothiazide, systolic blood pressure change measurement	DDX11 DNAAF1	1.87e-03	16	119	2	EFO_0005202, EFO_0006944
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	TSC1 MTOR	1.87e-03	16	119	2	DOID:0110861 (implicated_via_orthology)
Disease	ovarian neoplasm	MTOR TLR4 NR5A1 TP53	2.16e-03	134	119	4	C0919267
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	TLR4 MFN2 HADHA	2.33e-03	65	119	3	DOID:0080208 (biomarker_via_orthology)
Disease	Malignant neoplasm of ovary	MTOR TLR4 NR5A1 TP53	2.34e-03	137	119	4	C1140680
Disease	Carcinoma of bladder	TSC1 MTOR	2.37e-03	18	119	2	C0699885
Disease	myocardial infarction (implicated_via_orthology)	MAP3K5 JAK2 MTOR	2.43e-03	66	119	3	DOID:5844 (implicated_via_orthology)
Disease	portal hypertension (implicated_via_orthology)	JAK2 MTOR	2.64e-03	19	119	2	DOID:10762 (implicated_via_orthology)
Disease	hemifacial microsomia	SHROOM3 FRMD4A	2.64e-03	19	119	2	MONDO_0015398
Disease	stomach cancer (is_marker_for)	LRRN1 TRPC1 JAK2 ASPM	2.66e-03	142	119	4	DOID:10534 (is_marker_for)
Disease	neurodegenerative disease (implicated_via_orthology)	UBR1 RASA1 TRPC1 SCNN1A	2.87e-03	145	119	4	DOID:1289 (implicated_via_orthology)
Disease	obesity (biomarker_via_orthology)	FOXO3 JAK2 MTOR MFN2	3.01e-03	147	119	4	DOID:9970 (biomarker_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	TSC1 MTOR MITF TP53	3.09e-03	148	119	4	C0279702
Disease	pentachlorophenol measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022071
Disease	parathion measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022070
Disease	potassium chromate measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022072
Disease	mercuric chloride measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022068
Disease	heptachlor epoxide measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022067
Disease	methoxychlor measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022052
Disease	azinphos methyl measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022055
Disease	aldrin measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022054
Disease	dicofol measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022060
Disease	disulfoton measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022062
Disease	dieldrin measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022061
Disease	endrin measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022064
Disease	endosulfan measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022063
Disease	heptachlor measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022066
Disease	ethion measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022065
Disease	chlorpyrifos measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022057
Disease	cadmium chloride measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022056
Disease	diazinon measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022059
Disease	dibutyl phthalate measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0022058
Disease	environmental exposure measurement	EYS RPTOR TNS1	3.24e-03	73	119	3	EFO_0008360
Disease	DDT metabolite measurement	EYS RPTOR TNS1	3.37e-03	74	119	3	EFO_0007886
Disease	melanoma	MYO1B MAP3K5 TLR4 MITF TP53	3.38e-03	248	119	5	C0025202
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN9A	3.53e-03	22	119	2	DOID:2030 (implicated_via_orthology)
Disease	Bronchiectasis	SCNN1A DNAAF1	3.53e-03	22	119	2	C0006267
Disease	transient cerebral ischemia (biomarker_via_orthology)	ACVRL1 MAP3K5 MTOR MFN2	3.81e-03	157	119	4	DOID:224 (biomarker_via_orthology)
Disease	primary open angle glaucoma (is_implicated_in)	TLR4 TP53	3.86e-03	23	119	2	DOID:1070 (is_implicated_in)
Disease	sciatic neuropathy (implicated_via_orthology)	MTOR TLR4	3.86e-03	23	119	2	DOID:11446 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQDMAVIAPMLAKLG	TPST1	311	O60507
QQSRLPLPLMELMEN	CATSPERZ	141	Q9NTU4
FIVGLLLMQMPEEEA	EVI5L	201	Q96CN4
MAELQMLLEEEIPSG	ABI1	1	Q8IZP0
LMLLMALVTQGDPVK	ACVRL1	11	P37023
VSMPNLQDIAMPELA	DENND3	471	A2RUS2
NPLQAIQMVMDTLGI	ASPM	3461	Q8IZT6
SLLMSVGPIQSLQML	RBM33	1116	Q96EV2
NLPLSMDEQELEGML	RBMS2	141	Q15434
MPPLIQEMLENSEGL	RARA	406	P10276
RMIMFLDELGNVPEL	RASA1	966	P20936
MPQQARGAESIMLNL	RIC1	661	Q4ADV7
LTENDMLPNMRIGAL	JAK2	816	O60674
ISPAEMANLMLQGLL	INO80	896	Q9ULG1
MAAIGQRPLLMEEIS	NUP205	1246	Q92621
LDMPLVLDQGLTRQM	OMP	11	P47874
HIQGLSAMMPLLQEI	NR1I3	336	Q14994
PQLMRLDNMLLAEGV	PBX3	106	P40426
VPMMLLNLVEQLGEA	RENBP	191	P51606
LMLNMLQESVAPALS	KCNE4	151	Q8WWG9
PGILIEMSEVQLMRL	MKKS	216	Q9NPJ1
MGPTEVLNQESLLDM	EYS	1711	Q5T1H1
MLGDVLMDQNVLPGV	NEIL3	176	Q8TAT5
EMLPNLEILMIGGNK	LRRN2	186	O75325
LLDGLMFQTPQEMGL	HLCS	481	P50747
LIVMNLPNVLMIGRD	CCDC88C	96	Q9P219
TEGMADLNEMILLLP	GSTA3	96	Q16772
PMAVRQLLLGNSTMI	FAM157A	26	C9JC47
LIDNLGPAMMLSDRL	NUP85	521	Q9BW27
SMLPTLREALMQQLN	PEX3	71	P56589
MRGAMELEPELLLQE	CRLF3	1	Q8IUI8
DYNQGLVLPMALELM	GALK1	46	P51570
EAPENMVQLLGELMN	GALK2	351	Q01415
PMAVRQLLLGNATMI	FAM157C	26	P0CG43
DGPIEILRLNNMMVT	GABRA4	111	P48169
QMMQLLLLALVTAAG	FOLR3	6	P41439
MMGLDLQPDLCSLLI	GCN1	1151	Q92616
AMLAQLLAELNSMPD	CDCA7L	226	Q96GN5
VLSPLPSQAMDDLML	TP53	31	P04637
QLMGLLRTLIDPENM	PPP4R3B	436	Q5MIZ7
VSMQDNDLLSPGILM	PITPNM2	591	Q9BZ72
LPQMMDEVGRILCNL	DDX11	681	Q96FC9
QTLIMADALMPQLVQ	HECTD4	556	Q9Y4D8
DLMALEELMQPVALG	GSTT2B	166	P0CG30
MQIVDELSILPAMLQ	HIPK3	141	Q9H422
ELSILPAMLQTNMGN	HIPK3	146	Q9H422
QTMQQDMIDGLKPLL	MFN2	491	O95140
LLAFPQSQGEMMELD	GRIN3A	196	Q8TCU5
MAVQLVPDSALGLLM	FRMD4A	1	Q9P2Q2
PMAVRQLLLGNSTMI	FAM157B	26	P0CG42
LENLTNGGILELMMR	CABIN1	476	Q9Y6J0
ANLLETLIVMPLDGM	GNRHR	86	P30968
DLGMVLLPVASQMEA	FAAP24	111	Q9BTP7
DLMALEELMQPVALG	GSTT2	166	P0CG29
PDMEVGATDLMNILN	CAPNS2	91	Q96L46
LNFMITPEGMQDQLL	DNAH7	3101	Q8WXX0
GPMIVLVLDEMDQLD	CDC6	276	Q99741
PLLEIMLGNLNTMEA	MACC1	271	Q6ZN28
LNKTQMDGMSLLPIL	GNS	386	P15586
LGLPADIQAAQAMMV	CLDN2	71	P57739
LESMPDLRVLNLMGN	DNAAF1	241	Q8NEP3
LAPMMSEVIRILQEG	HADHA	551	P40939
QLFNLLMEMLVSGDL	IPO9	146	Q96P70
ADMLLAVLNMPFALV	GPR63	126	Q9BZJ6
LGLMSLQRPFQMSID	GPR63	291	Q9BZJ6
NGEMVLSQLLPMAEQ	HEATR1	1026	Q9H583
MQVLQLTADQIAMLP	CSTF2T	581	Q9H0L4
AIADQLTLMANGMPL	SDR42E2	181	A6NKP2
MESLEPDAQVLMLGQ	FANCE	426	Q9HB96
SILEEQPMDMLLGLD	DDI2	311	Q5TDH0
KVQQELSRPGMLEML	GSS	306	P48637
MAGLAILANMLVPQD	SLC22A11	411	Q9NSA0
MPGINNGLSLMLRAE	SCNN1A	321	P37088
GKLLAEMLVQATQMP	POLRMT	576	O00411
LMIGENPVIGILDMN	LRRN1	196	Q6UXK5
MDIPQNITEFFMLGL	OR4C3	1	Q8NH37
TSEMLVNMGNLPLDE	MTOR	931	P42345
MKGLTELMQPNFELL	MAP3K5	231	Q99683
ASGLLLERMVDMPAN	METTL26	181	Q96S19
FELLLQMPMGAVLGE	FREM3	2101	P0C091
LPRLTDMAGTMNLND	FOXO3	366	O43524
MQSLMQAPLLIALGL	GM2A	1	P17900
MMDQLLRQGFLPLNT	RIMBP2	921	O15034
ELQDTMLLLSQMGPD	RAPGEF4	311	Q8WZA2
HLGNEMPRNNLLIEM	NR5A1	441	Q13285
PSRMLMLQLTDGIVQ	RMI1	131	Q9H9A7
ALEMGMPLLLQKQQE	RIF1	206	Q5UIP0
MATIPSIQLLGLEML	RIF1	421	Q5UIP0
LGMQIPIKNVEMLAS	HEPH	1096	Q9BQS7
TMMALKVLGELNILP	TENT5D	326	Q8NEK8
PSQMEDAELLLGVAM	SGSM3	341	Q96HU1
NQISLINMDLPMVSG	SCN5A	1831	Q14524
VQLIAMDLPMVSGDR	SCN9A	1821	Q15858
MDLMEGLFPRDVNLL	SHROOM3	1696	Q8TF72
GEINDSLMELLIMIN	PRPS1L1	61	P21108
SLLQAPMHIDRNILM	SLC10A5	131	Q5PT55
MESEMLQSPLLGLGE	RPTOR	1	Q8N122
PLLLLLIMGGMAQDS	ROBO4	16	Q8WZ75
KLQLIAMDLPMVSGD	SCN1A	1846	P35498
SEGPLQTRLLEMNLM	CLTC	576	Q00610
LLPSLQMDALRQDIM	CNKSR2	511	Q8WXI2
SILGPLQISMGQMLQ	TRPC1	521	P48995
LIQTLAEMTPGMFLD	PDCD11	836	Q14690
NVGELLAMLDSPMLG	TSC1	6	Q92574
LMLLTAQPQELVMFE	ZNF197	206	O14709
GALIFQVLMDIVPMD	SLC16A5	346	O15375
ILGLMDPALQMANTL	MITF	241	O75030
LEEVGIMALAPLAEM	SPATC1	86	Q76KD6
IMALAPLAEMLTSLQ	SPATC1	91	Q76KD6
LQDMVVMLLSLLEGN	RYR3	3871	Q15413
TLNMLMLDLEPASAA	TNS1	711	Q9HBL0
DIIMLQIGASLMDPN	UBR1	691	Q8IWV7
VMDIVRNLGLTPMDQ	STEAP4	166	Q687X5
LLGSDGSPLMDMLQL	NAPRT	426	Q6XQN6
LSEVMLSPAMQGVIL	USP28	766	Q96RU2
DLIAQQMMPEVRGAL	ATP6V1E1	201	P36543
AEVLMLGEMLTLPQN	TRAPPC13	56	A5PLN9
GALQMAEILMQKLPD	TRIP12	901	Q14669
MPLLNLSLDLSLNPM	TLR4	201	O00206
QAMLEGSPQLNMVGL	SLC25A24	416	Q6NUK1
GVMLLNLEAMRQSPL	XXYLT1	291	Q8NBI6
LLMMQPDNTIGDVRA	UBXN11	411	Q5T124
MDLGPLNICEEMTIL	GEMIN4	1	P57678
VILVRSNLPGLMDMQ	LRP4	1286	O75096
LDNMIGVGDMVLLEP	MYO1B	11	O43795
VLENILQPMIVSGML	MYO5A	1616	Q9Y4I1
GVLQPMIVSAMLENE	MYO5B	1611	Q9ULV0