Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of adipose tissue development	NCOA2 NCOA1 SORL1	3.02e-05	14	92	3	GO:1904179
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	ATP12A WNK4 WNK2 SLC12A5	7.89e-05	51	92	4	GO:1990573
GeneOntologyBiologicalProcess	regulation of adipose tissue development	NCOA2 NCOA1 SORL1	1.08e-04	21	92	3	GO:1904177
GeneOntologyBiologicalProcess	positive regulation of female receptivity	NCOA2 NCOA1	1.17e-04	4	92	2	GO:0045925
GeneOntologyBiologicalProcess	cellular response to Thyroglobulin triiodothyronine	NCOA2 NCOA1	1.17e-04	4	92	2	GO:1904017
Domain	DUF1518	NCOA2 NCOA1	7.33e-05	3	93	2	PF07469
Domain	Nuc_rcpt_coact_Ncoa-typ	NCOA2 NCOA1	7.33e-05	3	93	2	IPR014920
Domain	SRC-1	NCOA2 NCOA1	7.33e-05	3	93	2	IPR014935
Domain	Src1_rcpt_coact	NCOA2 NCOA1	7.33e-05	3	93	2	IPR008955
Domain	Nuclear_rcpt_coactivator	NCOA2 NCOA1	7.33e-05	3	93	2	IPR017426
Domain	-	NCOA2 NCOA1	7.33e-05	3	93	2	4.10.630.10
Domain	DUF1518	NCOA2 NCOA1	7.33e-05	3	93	2	IPR010011
Domain	DUF1518	NCOA2 NCOA1	7.33e-05	3	93	2	SM01151
Domain	SRC-1	NCOA2 NCOA1	7.33e-05	3	93	2	PF08832
Domain	Nuc_rec_co-act	NCOA2 NCOA1	7.33e-05	3	93	2	PF08815
Domain	Nuc_rcpt_coact	NCOA2 NCOA1	3.63e-04	6	93	2	IPR009110
Domain	OSR1_C	WNK4 WNK2	3.63e-04	6	93	2	PF12202
Domain	Kinase_OSR1/WNK_CCT	WNK4 WNK2	3.63e-04	6	93	2	IPR024678
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SLAIN2 IRS4 SBF1 IFT74 MAP4K1 SIK3 MAST2 SRRM2 ARHGEF16 WNK4 TNS3 CCDC102A SHKBP1	7.29e-07	861	96	13	36931259
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NCOA2 SLAIN2 IRS4 IFT74 POGZ SRCAP UBN2 PRRC2A HCFC1 CSTF2T	2.96e-06	549	96	10	38280479
Pubmed	Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation.	NCOA2 NCOA1 PPP1CC	3.31e-06	11	96	3	16109736
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MON2 IRS4 GATAD2A AARS2 IFT74 MTHFD1L EXOC2 NFS1 COG5 HCFC1	3.53e-06	560	96	10	35241646
Pubmed	A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.	SF3A1 POGZ HCFC1	7.26e-06	14	96	3	10976766
Pubmed	SRC-1 and TIF2 control energy balance between white and brown adipose tissues.	NCOA2 NCOA1	7.54e-06	2	96	2	12507421
Pubmed	Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction.	NCOA2 NCOA1	7.54e-06	2	96	2	15070739
Pubmed	Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency.	NCOA2 NCOA1	7.54e-06	2	96	2	11897715
Pubmed	Tumor necrosis factor-alpha suppresses the expression of steroid receptor coactivator-1 and -2: a possible mechanism contributing to changes in steroid hormone responsiveness.	NCOA2 NCOA1	7.54e-06	2	96	2	15231721
Pubmed	Distinct steady-state nuclear receptor coregulator complexes exist in vivo.	NCOA2 NCOA1	7.54e-06	2	96	2	9751728
Pubmed	Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis.	NCOA2 NCOA1	7.54e-06	2	96	2	25148457
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 LATS2 PNPLA6 PTPRF SBF1 MTHFD1L SPEG FBXL19 SRCAP MAST2 LTBP4 HCFC1 WNK2	1.10e-05	1105	96	13	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MON2 ZNF512B SLAIN2 PNPLA6 GATAD2A FOXL2NB POGZ SIK3 SRCAP MAST2 SRRM2 LTBP4 SORL1	1.22e-05	1116	96	13	31753913
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	SLAIN2 SRRM2 PRRC2A PSRC1 SHKBP1	1.28e-05	108	96	5	19531213
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IRS4 SBF1 MTHFD1L SF3A1 POGZ LARP4 SRRM2 PRRC2A HCFC1 PPP1CC	1.35e-05	653	96	10	22586326
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOA2 SBF1 PLPPR4 NHSL2 DCHS1 RIMS1 SIK3 UBN2 PRRC2A WNK2 SLC12A5 PPP1CC	1.40e-05	963	96	12	28671696
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PNPLA6 GATAD2A SBF1 MTHFD1L AKAP10 POGZ EXOC2 SRCAP LARP4 SRRM2 HSPB8 ALDH7A1 TNS3 PPP1CC	2.07e-05	1353	96	14	29467282
Pubmed	The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.	NCOA2 NCOA1	2.26e-05	3	96	2	21035760
Pubmed	Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.	NCOA2 NCOA1	2.26e-05	3	96	2	24550004
Pubmed	Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.	NCOA2 NCOA1	2.26e-05	3	96	2	21059860
Pubmed	RORgammat recruits steroid receptor coactivators to ensure thymocyte survival.	NCOA2 NCOA1	2.26e-05	3	96	2	16148126
Pubmed	Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.	NCOA2 NCOA1	2.26e-05	3	96	2	16914740
Pubmed	Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.	NCOA2 NCOA1	2.26e-05	3	96	2	16675958
Pubmed	Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.	NCOA2 NCOA1	2.26e-05	3	96	2	9506940
Pubmed	Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers.	NCOA2 NCOA1	2.26e-05	3	96	2	28390937
Pubmed	SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1.	NCOA2 SRCAP	2.26e-05	3	96	2	14500758
Pubmed	The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium.	NCOA2 NCOA1	2.26e-05	3	96	2	24586072
Pubmed	Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human.	NCOA2 NCOA1	2.26e-05	3	96	2	17045797
Pubmed	Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.	NCOA2 NCOA1	2.26e-05	3	96	2	23927929
Pubmed	Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.	NCOA2 NCOA1	2.26e-05	3	96	2	33574497
Pubmed	Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.	NCOA2 NCOA1	2.26e-05	3	96	2	18845648
Pubmed	The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.	NCOA2 NCOA1	2.26e-05	3	96	2	12138202
Pubmed	Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.	NCOA2 NCOA1	2.26e-05	3	96	2	14757047
Pubmed	Structure and chromosomal locations of mouse steroid receptor coactivator gene family.	NCOA2 NCOA1	2.26e-05	3	96	2	10501088
Pubmed	Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators.	NCOA2 NCOA1	2.26e-05	3	96	2	12114525
Pubmed	Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice.	NCOA2 NCOA1	2.26e-05	3	96	2	15983373
Pubmed	The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.	NCOA2 NCOA1	2.26e-05	3	96	2	16423883
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NCOA2 GATAD2A AARS2 IFT74 SF3A1 MRPL38 POGZ FOXN3 COG5 HCFC1 SORL1	2.51e-05	857	96	11	25609649
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	NCOA2 DNHD1 IRS4 COL27A1 RIMS1 SORL1	2.52e-05	208	96	6	33230847
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	FYTTD1 AARS2 MTHFD1L NFS1 MDH2 CARS2 MTX1 ALDH7A1	2.99e-05	438	96	8	32628020
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ENPP7 LATS2 MAP4K1 SIK3 FBXL19 CARS2 HCFC1 WNK4 GALNT13 WNK2	3.47e-05	730	96	10	34857952
Pubmed	Human transcription factor protein interaction networks.	ZNF512B NCOA2 IRS4 GATAD2A NCOA1 MRPL38 POGZ SRCAP LARP4 UBN2 SRRM2 PRRC2A HCFC1 SORL1	3.76e-05	1429	96	14	35140242
Pubmed	miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.	NCOA2 NCOA1	4.51e-05	4	96	2	26066330
Pubmed	Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation.	NCOA2 NCOA1	4.51e-05	4	96	2	11818499
Pubmed	Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins.	NCOA2 NCOA1	4.51e-05	4	96	2	10454563
Pubmed	P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain.	NCOA2 NCOA1	4.51e-05	4	96	2	18267973
Pubmed	Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells.	NCOA2 NCOA1	4.51e-05	4	96	2	15331759
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK4 WNK2	4.51e-05	4	96	2	34384519
Pubmed	Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex.	NCOA2 NCOA1	4.51e-05	4	96	2	12024042
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK4 WNK2	4.51e-05	4	96	2	11571656
Pubmed	Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.	NCOA2 NCOA1	4.51e-05	4	96	2	17513608
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK4 WNK2	4.51e-05	4	96	2	11498583
Pubmed	Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity.	NCOA2 NCOA1	4.51e-05	4	96	2	19095746
Pubmed	Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.	NCOA2 NCOA1	4.51e-05	4	96	2	10594042
Pubmed	Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context.	NCOA2 NCOA1	4.51e-05	4	96	2	12403846
Pubmed	Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.	NCOA2 NCOA1	4.51e-05	4	96	2	22560224
Pubmed	A simple method to screen ligands of peroxisome proliferator-activated receptor delta.	NCOA2 NCOA1	4.51e-05	4	96	2	16930961
Pubmed	Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.	NCOA2 NCOA1	4.51e-05	4	96	2	26267537
Pubmed	Isoform-specific transcriptional regulation by thyroid hormone receptors: hormone-independent activation operates through a steroid receptor mode of co-activator interaction.	NCOA2 NCOA1	4.51e-05	4	96	2	11435616
Pubmed	Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.	NCOA2 NCOA1	4.51e-05	4	96	2	15563453
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	NCOA2 AARS2 NCOA1 SRRM2 WNK2 TNS3	4.75e-05	233	96	6	37704626
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	AARS2 MTHFD1L AKAP10 TFB2M AADAT NFS1 MDH2 CARS2 MTX1 ALDH7A1 AKR7A2	5.05e-05	926	96	11	20877624
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ZNF512B NEO1 PNPLA6 SBF1 MTHFD1L SF3A1 MRPL38 SIK3 NFS1 MDH2 CARS2 SRRM2 VPS13B PPP1CC	5.77e-05	1487	96	14	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SLAIN2 FYTTD1 MAN1A2 PNPLA6 SBF1 MTHFD1L MRPL38 TFB2M EXOC2 UBN2 PRRC2A CSTF2T PPP1CC SHKBP1	6.20e-05	1497	96	14	31527615
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	AARS2 MTHFD1L AKAP10 MRPL38 TFB2M AADAT NFS1 MDH2 CARS2 MTX1 ALDH7A1 AKR7A2	6.97e-05	1136	96	12	34800366
Pubmed	Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.	NCOA2 NCOA1	7.50e-05	5	96	2	10652338
Pubmed	Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.	NCOA2 NCOA1	7.50e-05	5	96	2	17950690
Pubmed	SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.	NCOA2 NCOA1	7.50e-05	5	96	2	17476305
Pubmed	Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function.	NCOA2 NCOA1	7.50e-05	5	96	2	17854779
Pubmed	Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.	NCOA2 NCOA1	7.50e-05	5	96	2	18511550
Pubmed	Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription.	NCOA2 NCOA1	7.50e-05	5	96	2	11514567
Pubmed	Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members.	NCOA2 NCOA1	7.50e-05	5	96	2	11014206
Pubmed	Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.	NCOA2 NCOA1	7.50e-05	5	96	2	14993927
Pubmed	Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.	NCOA2 NCOA1	7.50e-05	5	96	2	12714702
Pubmed	Regulation of transcription by a protein methyltransferase.	NCOA2 NCOA1	7.50e-05	5	96	2	10381882
Pubmed	Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.	NCOA2 NCOA1	7.50e-05	5	96	2	15721253
Pubmed	SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells.	NCOA2 NCOA1	7.50e-05	5	96	2	12514218
Pubmed	Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes.	NCOA2 NCOA1	7.50e-05	5	96	2	11376110
Pubmed	Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.	NCOA2 NCOA1	7.50e-05	5	96	2	18798693
Pubmed	Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.	NCOA2 NCOA1	7.50e-05	5	96	2	12554772
Pubmed	RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.	NCOA2 NCOA1	7.50e-05	5	96	2	23160820
Pubmed	SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.	NCOA2 NCOA1	7.50e-05	5	96	2	9812974
Pubmed	Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia.	IGSF8 NKX2-2	7.50e-05	5	96	2	12595239
Pubmed	A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.	NCOA2 NCOA1	7.50e-05	5	96	2	15026545
Pubmed	The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.	NCOA2 NCOA1	7.50e-05	5	96	2	10757795
Pubmed	2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts.	NCOA2 NCOA1	7.50e-05	5	96	2	12796488
Pubmed	Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status.	NCOA2 NCOA1	7.50e-05	5	96	2	10803578
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MON2 PTPRF SBF1 WDR97 MTHFD1L AKAP10 SRRM2 PRRC2A TNS3 SORL1 SHKBP1	7.92e-05	974	96	11	28675297
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF512B SLAIN2 SBF1 PLPPR4 POGZ SIK3 FRMD4B WNK2	1.12e-04	529	96	8	14621295
Pubmed	A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.	NCOA2 NCOA1	1.12e-04	6	96	2	16373399
Pubmed	Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.	NCOA2 NCOA1	1.12e-04	6	96	2	12630920
Pubmed	Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study.	MTHFD1L PSRC1	1.12e-04	6	96	2	19955471
Pubmed	Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells.	NCOA2 NCOA1	1.12e-04	6	96	2	16728408
Pubmed	Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function.	NCOA2 NCOA1	1.12e-04	6	96	2	24811170
Pubmed	Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.	NCOA2 NCOA1	1.12e-04	6	96	2	16923966
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	WNK4 WNK2	1.12e-04	6	96	2	21733846
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	IFT74 SF3A1 LARP4 SRRM2 PRRC2A HCFC1 CSTF2T	1.23e-04	399	96	7	35987950
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	IRS4 MTHFD1L SF3A1 ATP12A LARP4	1.43e-04	179	96	5	36261009
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	SLAIN2 IRS4 MTHFD1L SF3A1 MDH2 LARP4 PRRC2A PPP1CC	1.48e-04	551	96	8	34728620
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	AARS2 MTHFD1L AKAP10 MRPL38 TFB2M AADAT NFS1 MDH2 MTX1 ALDH7A1 AKR7A2	1.49e-04	1047	96	11	18614015
Interaction	YWHAH interactions	NCOA2 SLAIN2 IRS4 LATS2 SBF1 AARS2 NHSL2 IFT74 SPEG NCOA1 RIMS1 SIK3 MAST2 SRRM2 ARHGEF16 WNK2 ALDH7A1 TNS3 SHKBP1	6.46e-07	1102	94	19	int:YWHAH
GeneFamily	Cadherin related	FAT2 DCHS1	1.52e-03	17	62	2	24
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA2 NCOA1	1.52e-03	17	62	2	486
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MON2 NCOA2 NCOA1 FOXN3 SIK3 COG5 VPS13B	2.55e-07	199	96	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCOA2 FOXN3 SIK3 COG5 VPS13B TNS3	3.88e-06	193	96	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|Epithelial / Condition, Lineage and Cell class	FAT2 RIMS1 FOXN3 ATP12A WNK2 SORL1	4.36e-06	197	96	6	78ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
Drug	Ursolic acid [77-52-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A	PTPRF SLC16A3 IFT74 ORAI3 FOXN3 LYL1 ARHGEF16 HCFC1 CSTF2T SORL1	1.05e-08	196	96	10	7181_DN
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; PC3; HT_HG-U133A	SBF1 ORAI3 POGZ FOXN3 MAST2 SRRM2 PRRC2A HSPB8 CSTF2T	1.60e-07	198	96	9	4592_DN
Drug	Rifabutin [72559-06-9]; Down 200; 4.8uM; MCF7; HT_HG-U133A	NCOA2 TRMO SRCAP MAST2 SRRM2 ARHGEF16 HCFC1	9.42e-06	175	96	7	3873_DN
Drug	Paclitaxel [33069-62-4]; Up 200; 4.6uM; PC3; HT_HG-U133A	MAN1A2 IFT74 ADAM29 SRCAP FRMD4B SLC12A5 AKR7A2	1.78e-05	193	96	7	6720_UP
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; HL60; HG-U133A	SBF1 NCOA1 TFB2M SRRM2 HCFC1 CSTF2T PPP1CC	1.78e-05	193	96	7	1982_DN
Drug	Tridihexethyl chloride; Up 200; 11.4uM; MCF7; HT_HG-U133A	GATAD2A MAST2 SRRM2 LTBP4 PRRC2A HCFC1 CSTF2T	1.84e-05	194	96	7	3526_UP
Drug	Furazolidone [67-45-8]; Down 200; 17.8uM; MCF7; HT_HG-U133A	NCOA2 NCOA1 FOXN3 SRCAP SRRM2 LTBP4 HCFC1	1.90e-05	195	96	7	3358_DN
Drug	sulindac sulfone; Up 200; 50uM; MCF7; HG-U133A	NCOA2 FAT2 SPEG TCL1A TRMO MAST2 LTBP4	2.03e-05	197	96	7	314_UP
Drug	Monocrotaline [315-22-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	SBF1 SLC16A3 NCOA1 FOXN3 SRCAP PRRC2A HCFC1	2.10e-05	198	96	7	2749_DN
Drug	Iocetamic acid [16034-77-8]; Down 200; 6.6uM; MCF7; HT_HG-U133A	NCOA2 FOXN3 SIK3 SRCAP MAST2 SRRM2 CSTF2T	2.10e-05	198	96	7	3361_DN
Drug	Convolamine hydrochloride [500-56-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	SLC16A3 AKAP10 SRCAP LYL1 SRRM2 HCFC1 ALDH7A1	2.17e-05	199	96	7	5876_DN
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A	NCOA2 SPEG NCOA1 POGZ SRRM2 HCFC1 ALDH7A1	2.24e-05	200	96	7	5853_DN
Disease	Ovarian Mucinous Adenocarcinoma	SPEG MAST2 WNK4	1.28e-04	31	93	3	C1335167
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK4 WNK2	1.46e-04	6	93	2	DOID:4479 (implicated_via_orthology)
Disease	cortical thickness	MON2 NCOA2 NEO1 GATAD2A PTPRF FOXL2NB AKAP10 EXOC2 VIT MAST2 FRMD4B WNK2	1.95e-04	1113	93	12	EFO_0004840
Disease	blindness (implicated_via_orthology)	PNPLA6 MYO15A	2.72e-04	8	93	2	DOID:1432 (implicated_via_orthology)
Disease	cerebellar ataxia (implicated_via_orthology)	PNPLA6 AARS2	2.72e-04	8	93	2	DOID:0050753 (implicated_via_orthology)
Disease	level of Ceramide (d42:1) in blood serum	GATAD2A SIK3	4.35e-04	10	93	2	OBA_2045187
Disease	level of Triacylglycerol (51:3) in blood serum	GATAD2A SIK3	4.35e-04	10	93	2	OBA_2045163
Disease	diffuse large B-cell lymphoma	NCOA1 EXOC2	8.72e-04	14	93	2	EFO_0000403
Disease	level of triacylglycerol (56:6) in blood serum	GATAD2A SIK3	1.15e-03	16	93	2	OBA_2020007
Disease	Keloid	FOXL2NB HYAL2	1.30e-03	17	93	2	EFO_0004212
Disease	pulse pressure measurement	SLAIN2 LATS2 GATAD2A COL27A1 POGZ FBXL19 SRCAP COG5 LARP4 MAST2 HCFC1 TNS3	1.41e-03	1392	93	12	EFO_0005763
Disease	intellectual disability (implicated_via_orthology)	IRS4 GATAD2A POGZ	1.74e-03	75	93	3	DOID:1059 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SBF1 ATP12A ALDH7A1 SLC12A5	1.79e-03	163	93	4	DOID:1826 (implicated_via_orthology)
Disease	progranulin measurement	NCOA2 PSRC1	2.18e-03	22	93	2	EFO_0004625

Protein segments in the cluster

Peptide	Gene	Start	Entry
TLRRLPGTPLMPSAG	nan	11	Q8NBF4
PGTPLMPSAGAVRVV	nan	16	Q8NBF4
PVRITGTTRGMTPPG	ADAM29	36	Q9UKF5
PSPIRTMTDILSRGP	AADAT	16	Q8N5Z0
SRPPPPRVASVLGTM	AKR7A2	31	O43488
SRMIGGPILPSERSG	ALDH7A1	161	P49419
MRGAGPSPRQSPRTL	AKAP10	1	O43572
PASGLPMVRGSPRVR	ARHGEF16	31	Q5VV41
DPSLTPSIGPVSRGM	DNHD1	2746	Q96M86
LVGTMSTMPGLPTRP	MTHFD1L	946	Q6UB35
SLTPPMLSGVVRRQP	FBXL19	471	Q6PCT2
RMRSSLTPLGPPVSR	RAB36	66	O95755
PMPTREPPKTRGSRG	OCEL1	56	Q9H607
PMVPTSRVPGTLAPV	ORAI3	186	Q9BRQ5
SARMPGSVIPPPLVR	GATAD2A	211	Q86YP4
GPQATTGTPLVTMRP	HCFC1	491	P51610
LRTVPMGGVRLVTPV	HCFC1	846	P51610
TTGHVRLMRPLGPSG	DCHS1	946	Q96JQ0
GLPTRTSPVRGSKRM	PNPLA6	356	Q8IY17
MRAGPGPTVTLALVL	HYAL2	1	Q12891
MRSGTVPTPLVVGLG	NFS1	291	Q9Y697
PGPVPEGSIRIYSMR	GSTO1	16	P78417
LMRPLVVTAQPGSGP	SLC16A3	196	O15427
TSPGKGLMPTPVTRR	LATS2	156	Q9NRM7
GLMPTPVTRRPSFEG	LATS2	161	Q9NRM7
PAFGMLTVPLRTPLT	MYO15A	2061	Q9UKN7
MTRTPVGSARTRPKP	FOXL2NB	1	Q6ZUU3
MGTVRPPRPSLLLVS	LRRC3	1	Q9BY71
VVIPAGVPRKPGMTR	MDH2	96	P40926
VGLLSMIDPPRSTVP	ATP12A	601	P54707
PGTLRSGMVPRGPTA	HSPB8	61	Q9UJY1
MSRSRQPPLVTGISP	EXOC2	1	Q96KP1
PPGSRVVMVRVTPAF	FAT2	376	Q9NYQ8
VLMRGFVSVVPPIRP	OR51B5	146	Q9H339
PPGGTTGELSRMTII	MUC19	7356	Q7Z5P9
PASRMPLTSRSVPPG	PSRC1	286	Q6PGN9
PVLIGPISGMSRPFV	MON2	1196	Q7Z3U7
RRTTVPSGPPMTAIL	SBF1	536	O95248
MSSAVGPRGPRPPTV	RIMS1	1	Q86UR5
RTLPVRTPTMAGGLF	GALNT13	281	Q8IUC8
GGSPPRSGTVMVRIL	PCDHB4	216	Q9Y5E5
SAVRGGPGRSTMPTP	COG5	306	Q9UP83
RPQGGRSMPTTPVLT	FRMD4B	656	Q9Y2L6
GPRGRQAPTSPPRMT	IGSF8	161	Q969P0
RVATAMPPGTARPGS	IFT74	36	Q96LB3
SRPVTTIVGEPLPMP	AWAT2	276	Q6E213
RLPSVGGRMTAPKTP	LINC00304	61	Q8N9R0
VRPLPITPIGVTAAM	FOXN3	291	O00409
LTILGSPSPERMGPA	CCDC102A	21	Q96A19
MLPASVGGSTRTPRP	COL27A1	336	Q8IZC6
PLPGSSSRMPGELVL	LARP4	486	Q71RC2
PGVAMPTTELGTLRP	LYL1	71	P12980
DPRSLGPMVPSLLTG	MAST2	1551	Q6P0Q8
MPRPGTSGRRPLLLV	LTBP4	1	Q8N2S1
MTTPALLPLSGRRIP	MAN1A2	1	O60476
VLGPSRPGVPTMSLL	ITIH6	956	Q6UXX5
RGLEMRGPVPSSRGP	CSTF2T	456	Q9H0L4
PPSSRPLLVMGLLGT	ENPP7	436	Q6UWV6
VVPIDRVGGSMLTPR	PTPRF	1136	P10586
MSRRFTVTSLPPAGP	SLC12A5	1	Q9H2X9
VPMRPGVATPLVSSS	IRS4	701	O14654
SMPISTPGERRTPLT	MUC17	2976	Q685J3
MLLGGPPRSPRSGTS	MTX1	1	Q13505
GSPVRGLRTPEIPMT	MAP4K1	736	Q92918
VMTRGVRPPAPSLKA	SORL1	1836	Q92673
MLRTTRGPGLGPPLL	CARS2	1	Q9HA77
RSPGMLEPLGSSRTP	SRRM2	2131	Q9UQ35
PAGTTAMRSGLPRPS	SLAIN2	526	Q9P270
AREISSPGRPPGLMS	NHSL2	696	Q5HYW2
PSLGTMPVQVTPPRG	NCOA1	1016	Q15788
PVRPGSTMPVRPTTN	POGZ	211	Q7Z3K3
SIGTLGRSRPPMPVV	NEO1	1401	Q92859
SGPPMRLVEPVGRPS	PRRC2A	291	P48634
LGGRPAPVRRSNTMP	SHKBP1	151	Q8TBC3
KRPRGPSPLVTMTPA	SIK3	566	Q9Y2K2
PRSGGVIKPPAMSSR	TFB2M	156	Q9H5Q4
GMEVTPLPSPRRVAV	NKX2-2	191	O95096
GPTLMTRPGQPALTR	PEX13	36	Q92968
GIMRPGSTSLPETPR	SEC31B	921	Q9NQW1
GRLPTPTLGTARAPM	SRCAP	1351	Q6ZRS2
PMVSLLGSGRPTGSP	TNS3	956	Q68CZ2
PMASVVRLPPGSVIA	SF3A1	601	Q15459
PGMSGPPLVLRRILR	AARS2	341	Q5JTZ9
VVLGRPMTPTQIGPS	TCL1A	56	P56279
RMSPGVAGSPRIPPS	NCOA2	491	Q15596
ATLRMQPRPGLRPTG	NCOA2	1166	Q15596
MPGGPRVSIQSRPGS	PLPPR4	516	Q7Z2D5
TGIRKGISPMNRPPL	FYTTD1	111	Q96QD9
TGRPLPGTSTRYVMP	SMOC1	276	Q9H4F8
MRGLEESGPRPTATP	TRMO	1	Q9BU70
VGSRISMPTTKPRPG	UBN2	786	Q6ZU65
TSAVLGRRTPPLGPM	MRPL38	21	Q96DV4
VTMPRRPPPSGGLSS	SPEG	1906	Q15772
PPPSPTGRLMRLAVA	WDR97	241	A6NE52
RPPIPGTTAQPVTLM	VIT	171	Q6UXI7
ATRPVTPPRGMITKQ	PPP1CC	306	P36873
GISKPVSVGRPMPVT	ZNF512B	211	Q96KM6
MAGPVPTSPVRSSIG	VPS13B	1256	Q7Z7G8
PPLIRTMPRSSGAQG	TRPC5	811	Q9UL62
GPETPSRVGMKVPTI	WNK2	1891	Q9Y3S1
SLQRSEPPGPGIMRR	WNK4	1201	Q96J92
TGTRAPPLTRPMSLA	KIAA1522	251	Q9P206