Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase regulator activity

SOCS5 SOCS4

8.13e-0516172GO:0046935
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

ADGRF1 GNRHR HTR3D FLT1 TAS2R41

4.41e-031353175GO:0004888
GeneOntologyMolecularFunctionantiporter activity

CLCN5 SLC9A2

6.02e-03138172GO:0015297
GeneOntologyBiologicalProcessnegative regulation of epidermal growth factor-activated receptor activity

SOCS5 SOCS4

6.67e-0515172GO:0007175
GeneOntologyBiologicalProcessregulation of epidermal growth factor-activated receptor activity

SOCS5 SOCS4

1.46e-0422172GO:0007176
GeneOntologyBiologicalProcessnegative regulation of protein tyrosine kinase activity

SOCS5 SOCS4

2.74e-0430172GO:0061099
GeneOntologyBiologicalProcessnegative regulation of epidermal growth factor receptor signaling pathway

SOCS5 SOCS4

3.13e-0432172GO:0042059
GeneOntologyBiologicalProcessnegative regulation of signaling receptor activity

SOCS5 SOCS4

3.33e-0433172GO:2000272
GeneOntologyBiologicalProcessnegative regulation of ERBB signaling pathway

SOCS5 SOCS4

4.19e-0437172GO:1901185
GeneOntologyBiologicalProcessglycerophospholipid biosynthetic process

PTDSS2 SOCS5 SOCS4

7.00e-04217173GO:0046474
GeneOntologyBiologicalProcessnegative regulation of peptidyl-tyrosine phosphorylation

SOCS5 SOCS4

1.06e-0359172GO:0050732
GeneOntologyBiologicalProcessphospholipid biosynthetic process

PTDSS2 SOCS5 SOCS4

1.29e-03268173GO:0008654
GeneOntologyBiologicalProcessglycerolipid biosynthetic process

PTDSS2 SOCS5 SOCS4

1.29e-03268173GO:0045017
GeneOntologyBiologicalProcessphosphatidylinositol phosphate biosynthetic process

SOCS5 SOCS4

1.33e-0366172GO:0046854
GeneOntologyBiologicalProcessregulation of vascular endothelial growth factor production

SULF1 FLT1

1.33e-0366172GO:0010574
GeneOntologyBiologicalProcessvascular endothelial growth factor receptor signaling pathway

SULF1 FLT1

1.45e-0369172GO:0048010
GeneOntologyBiologicalProcessregulation of protein tyrosine kinase activity

SOCS5 SOCS4

1.45e-0369172GO:0061097
GeneOntologyBiologicalProcessvascular endothelial growth factor production

SULF1 FLT1

1.49e-0370172GO:0010573
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process

HERC3 UBA1 SOCS5 SOCS4

1.58e-03640174GO:0006511
GeneOntologyBiologicalProcessmodification-dependent protein catabolic process

HERC3 UBA1 SOCS5 SOCS4

1.69e-03651174GO:0019941
GeneOntologyBiologicalProcessmodification-dependent macromolecule catabolic process

HERC3 UBA1 SOCS5 SOCS4

1.73e-03656174GO:0043632
GeneOntologyBiologicalProcessglycerophospholipid metabolic process

PTDSS2 SOCS5 SOCS4

2.14e-03320173GO:0006650
GeneOntologyBiologicalProcesspositive regulation of proteasomal ubiquitin-dependent protein catabolic process

SOCS5 SOCS4

2.19e-0385172GO:0032436
GeneOntologyBiologicalProcessnegative regulation of endothelial cell proliferation

SULF1 FLT1

2.19e-0385172GO:0001937
GeneOntologyBiologicalProcessregulation of epidermal growth factor receptor signaling pathway

SOCS5 SOCS4

2.24e-0386172GO:0042058
GeneOntologyBiologicalProcesspeptidyl-tyrosine phosphorylation

FLT1 SOCS5 SOCS4

2.28e-03327173GO:0018108
GeneOntologyBiologicalProcesspeptidyl-tyrosine modification

FLT1 SOCS5 SOCS4

2.32e-03329173GO:0018212
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex

SOCS5 SOCS4

2.20e-0429162GO:0005942
DomainSOCS

SOCS5 SOCS4

7.80e-072172PF12610
DomainSOCS4/SOCS5_dom

SOCS5 SOCS4

7.80e-072172IPR022252
DomainSOCS

SOCS5 SOCS4

1.47e-0420172SM00253
DomainSOCS_box

SOCS5 SOCS4

5.38e-0438172PF07525
DomainSOCS_box

SOCS5 SOCS4

5.66e-0439172SM00969
DomainSOCS_box

SOCS5 SOCS4

5.66e-0439172IPR001496
DomainSOCS

SOCS5 SOCS4

5.66e-0439172PS50225
DomainSH2

SOCS5 SOCS4

3.73e-03101172PF00017
DomainSH2

SOCS5 SOCS4

4.41e-03110172SM00252
DomainSH2

SOCS5 SOCS4

4.49e-03111172PS50001
DomainSH2

SOCS5 SOCS4

4.57e-03112172IPR000980
Domain-

SOCS5 SOCS4

4.57e-031121723.30.505.10
Pubmed

The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

SOCS5 SOCS4

2.25e-07217222423360
Pubmed

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

SOCS5 SOCS4

6.74e-07317228195529
Pubmed

Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma.

SOCS5 SOCS4

1.35e-06417231200002
Pubmed

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

SOCS5 SOCS4

2.25e-06517215590694
Pubmed

The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.

SOCS5 SOCS4

1.23e-051117219385048
Pubmed

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

SOCS5 SOCS4

1.75e-051317223990909
Pubmed

RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.

SOCS5 SOCS4

6.70e-052517229361558
Pubmed

The SOCS box: a tale of destruction and degradation.

SOCS5 SOCS4

1.82e-044117212076535
Pubmed

Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.

SOCS5 SOCS4

1.91e-044217224210661
CytobandEnsembl 112 genes in cytogenetic band chrXp11

CLCN5 UBA1

8.43e-03377172chrXp11
GeneFamilySH2 domain containing|Suppressors of cytokine signaling

SOCS5 SOCS4

9.40e-068112764
GeneFamilySH2 domain containing

SOCS5 SOCS4

1.64e-03101112741
Drugestradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA

MIOS SULF1 SLC9A2 SOCS5

1.26e-052001741079_DN
DiseasePrecancerous Conditions

SULF1 SOCS4

1.60e-03110162C0032927
DiseaseCondition, Preneoplastic

SULF1 SOCS4

1.60e-03110162C0282313
DiseaseAdenocarcinoma of lung (disorder)

CMTR2 FLT1

5.46e-03206162C0152013

Protein segments in the cluster

PeptideGeneStartEntry
QPHCVFWDFSHLQWN

ADGRF1

531

Q5T601
FWDFSHLQWNDAGCH

ADGRF1

536

Q5T601
HRFPCHWSWVANTLN

CMTR2

161

Q8IYT2
WFSDTCFVEHNWFHL

HERC3

776

Q15034
CVTHCSFSQWWHQAF

GNRHR

196

P30968
TGGFWFNHEHCCWNS

CLCN5

161

P51795
HLHWHFLNSATFWFC

TAS2R41

86

P59536
EQWNHNFSFDAHDPC

SOCS5

431

O75159
LEHQLPNFSECWWDH

PTDSS2

231

Q9BVG9
EQWNHNFSFDAHDPC

SOCS4

336

Q8WXH5
CHHARPWHNQFVQWN

HTR3D

86

Q70Z44
NNWFTWCHNCRHGGH

MIOS

821

Q9NXC5
NHEWNWAFVCFTLAF

SLC9A2

386

Q9UBY0
CVTWACHHWHTQYSN

UBA1

706

P22314
WFWHPCNHNHSEARC

FLT1

466

P17948
CFTHDNNHWQTAPFW

SULF1

746

Q8IWU6
DFDPHHFWQWSSFSD

SLC66A2

131

Q8N2U9
CVFCWWHHNNPVGTE

TYW1B

356

Q6NUM6