Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	THSD4 FBLN5 FN1 EFEMP2 SSPOP EFEMP1 HMCN2 HMCN1 SBSPON MUC6	1.06e-07	188	112	10	GO:0005201
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	1.86e-04	4	112	2	GO:0005219
GeneOntologyMolecularFunction	calcium ion binding	FBLN7 FBLN5 EFEMP2 VWCE TENM2 RYR2 RYR3 THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	2.92e-04	749	112	13	GO:0005509
GeneOntologyMolecularFunction	glutamate receptor activity	GRM3 GRM8 GRIN3A	4.55e-04	27	112	3	GO:0008066
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	4.61e-04	6	112	2	GO:0048763
GeneOntologyMolecularFunction	transition metal ion binding	UBA5 TRAF6 CAD FN1 LITAF OGFOD2 ZNFX1 UBR7 F8 TAB3 ZPR1 ARIH2 ANKIB1 DMD ZSWIM4 PCK2	9.66e-04	1189	112	16	GO:0046914
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	TRAF6 ARIH2 ANKIB1	1.07e-03	36	112	3	GO:0031624
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM3 GRM8	1.09e-03	9	112	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM3 GRM8	1.09e-03	9	112	2	GO:0001640
GeneOntologyBiologicalProcess	elastic fiber assembly	THSD4 FBLN5 EFEMP2	2.36e-05	11	110	3	GO:0048251
GeneOntologyBiologicalProcess	positive regulation of smooth muscle cell-matrix adhesion	PCSK5 EFEMP2	2.82e-05	2	110	2	GO:1905609
GeneOntologyCellularComponent	extracellular matrix	THSD4 FBLN7 FBLN5 FN1 EFEMP2 TFIP11 SSPOP TSPAN9 EFEMP1 HMCN2 HMCN1 ADAMTS6 SBSPON MUC6 CCN3	1.79e-06	656	110	15	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	THSD4 FBLN7 FBLN5 FN1 EFEMP2 TFIP11 SSPOP TSPAN9 EFEMP1 HMCN2 HMCN1 ADAMTS6 SBSPON MUC6 CCN3	1.86e-06	658	110	15	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	THSD4 FBLN5 FN1 EFEMP2 SSPOP TSPAN9 EFEMP1 HMCN2 HMCN1 SBSPON CCN3	1.11e-04	530	110	11	GO:0062023
GeneOntologyCellularComponent	elastic fiber	FBLN5 EFEMP2	2.72e-04	5	110	2	GO:0071953
GeneOntologyCellularComponent	basement membrane	FN1 EFEMP2 EFEMP1 HMCN2 HMCN1	4.68e-04	122	110	5	GO:0005604
MousePheno	abnormal ascending aorta morphology	THSD4 FBLN5 EFEMP2 HECTD1	1.12e-05	22	91	4	MP:0009867
Domain	EGF_1	FBLN7 FBLN5 FN1 EFEMP2 ADAM29 VWCE SSPOP TENM2 THBD EFEMP1 HMCN2 HMCN1 TENM3 DLK2 NOTCH2	2.29e-11	255	109	15	PS00022
Domain	EGF_3	FBLN7 FBLN5 EFEMP2 ADAM29 VWCE SSPOP TENM2 THBD EFEMP1 HMCN2 HMCN1 TENM3 DLK2 NOTCH2	9.41e-11	235	109	14	PS50026
Domain	EGF_CA	FBLN7 FBLN5 EFEMP2 VWCE TENM2 THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	1.31e-10	122	109	11	SM00179
Domain	EGF-like_Ca-bd_dom	FBLN7 FBLN5 EFEMP2 VWCE TENM2 THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	1.56e-10	124	109	11	IPR001881
Domain	EGF-like_dom	PCSK5 FBLN7 FBLN5 EFEMP2 ADAM29 VWCE TENM2 THBD EFEMP1 HMCN2 HMCN1 TENM3 DLK2 NOTCH2	2.02e-10	249	109	14	IPR000742
Domain	EGF_Ca-bd_CS	FBLN7 FBLN5 EFEMP2 VWCE THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	2.48e-10	97	109	10	IPR018097
Domain	EGF_CA	FBLN7 FBLN5 EFEMP2 VWCE THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	3.04e-10	99	109	10	PS01187
Domain	ASX_HYDROXYL	FBLN7 FBLN5 EFEMP2 VWCE THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	3.36e-10	100	109	10	PS00010
Domain	EGF-like_CS	FBLN7 FBLN5 FN1 EFEMP2 ADAM29 VWCE TENM2 THBD EFEMP1 HMCN2 HMCN1 TENM3 DLK2 NOTCH2	3.76e-10	261	109	14	IPR013032
Domain	EGF_2	FBLN7 FBLN5 EFEMP2 ADAM29 VWCE SSPOP TENM2 THBD EFEMP1 HMCN2 HMCN1 TENM3 DLK2 NOTCH2	4.59e-10	265	109	14	PS01186
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN7 FBLN5 EFEMP2 VWCE THBD EFEMP1 HMCN2 HMCN1 DLK2 NOTCH2	6.01e-10	106	109	10	IPR000152
Domain	EGF_CA	FBLN7 FBLN5 EFEMP2 VWCE THBD EFEMP1 HMCN2 HMCN1 NOTCH2	1.78e-09	86	109	9	PF07645
Domain	EGF	PCSK5 FBLN7 FBLN5 EFEMP2 VWCE TENM2 THBD EFEMP1 HMCN1 TENM3 DLK2 NOTCH2	1.27e-08	235	109	12	SM00181
Domain	Growth_fac_rcpt_	PCSK5 FBLN5 EFEMP2 VWCE THBD EFEMP1 HMCN2 HMCN1 NOTCH2 CCN3	2.60e-08	156	109	10	IPR009030
Domain	cEGF	FBLN5 EFEMP2 THBD EFEMP1 HMCN1	3.68e-07	26	109	5	PF12662
Domain	cEGF	FBLN5 EFEMP2 THBD EFEMP1 HMCN1	3.68e-07	26	109	5	IPR026823
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.24e-07	12	109	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.24e-07	12	109	4	IPR027970
Domain	TSP_1	THSD4 SSPOP HMCN1 ADAMTS6 SBSPON CCN3	1.78e-06	63	109	6	PF00090
Domain	TSP1	THSD4 SSPOP HMCN1 ADAMTS6 SBSPON CCN3	2.15e-06	65	109	6	SM00209
Domain	TSP1_rpt	THSD4 SSPOP HMCN1 ADAMTS6 SBSPON CCN3	2.15e-06	65	109	6	IPR000884
Domain	TSP1	THSD4 SSPOP HMCN1 ADAMTS6 SBSPON CCN3	2.15e-06	65	109	6	PS50092
Domain	PLAC	THSD4 PCSK5 ADAMTS6	6.72e-05	14	109	3	PF08686
Domain	Rhs_assc_core	TENM2 TENM3	1.01e-04	3	109	2	IPR022385
Domain	Ryanodine_rcpt	RYR2 RYR3	1.01e-04	3	109	2	IPR003032
Domain	Ryanrecept_TM4-6	RYR2 RYR3	1.01e-04	3	109	2	IPR009460
Domain	RyR	RYR2 RYR3	1.01e-04	3	109	2	PF02026
Domain	RR_TM4-6	RYR2 RYR3	1.01e-04	3	109	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	1.01e-04	3	109	2	IPR013333
Domain	VWF_dom	VWCE SSPOP MUC6 CCN3	1.04e-04	42	109	4	IPR001007
Domain	VWC_out	VWCE SSPOP MUC6	1.75e-04	19	109	3	SM00215
Domain	PLAC	THSD4 PCSK5 ADAMTS6	1.75e-04	19	109	3	PS50900
Domain	PLAC	THSD4 PCSK5 ADAMTS6	1.75e-04	19	109	3	IPR010909
Domain	Tox-GHH_dom	TENM2 TENM3	2.01e-04	4	109	2	IPR028916
Domain	G2F	HMCN2 HMCN1	2.01e-04	4	109	2	PF07474
Domain	Tox-GHH	TENM2 TENM3	2.01e-04	4	109	2	PF15636
Domain	NIDOGEN_G2	HMCN2 HMCN1	2.01e-04	4	109	2	PS50993
Domain	GFP	HMCN2 HMCN1	2.01e-04	4	109	2	IPR009017
Domain	Ten_N	TENM2 TENM3	2.01e-04	4	109	2	IPR009471
Domain	Ten_N	TENM2 TENM3	2.01e-04	4	109	2	PF06484
Domain	TENEURIN_N	TENM2 TENM3	2.01e-04	4	109	2	PS51361
Domain	G2_nidogen/fibulin_G2F	HMCN2 HMCN1	2.01e-04	4	109	2	IPR006605
Domain	Galactose-bd-like	PCSK5 UBOX5 SSPOP F8 HECTD1	2.24e-04	94	109	5	IPR008979
Domain	zf-RanBP	TAB3 SHARPIN ZRANB1	2.75e-04	22	109	3	PF00641
Domain	ZnF_RBZ	TAB3 SHARPIN ZRANB1	3.15e-04	23	109	3	SM00547
Domain	ZF_RANBP2_2	TAB3 SHARPIN ZRANB1	3.15e-04	23	109	3	PS50199
Domain	YD	TENM2 TENM3	3.34e-04	5	109	2	IPR006530
Domain	ZF_RANBP2_1	TAB3 SHARPIN ZRANB1	3.58e-04	24	109	3	PS01358
Domain	Znf_RanBP2	TAB3 SHARPIN ZRANB1	4.05e-04	25	109	3	IPR001876
Domain	Cys_knot_C	SSPOP MUC6 CCN3	4.05e-04	25	109	3	IPR006207
Domain	CTCK_2	SSPOP MUC6 CCN3	4.05e-04	25	109	3	PS01225
Domain	RIH_assoc-dom	RYR2 RYR3	4.99e-04	6	109	2	IPR013662
Domain	Ins145_P3_rec	RYR2 RYR3	4.99e-04	6	109	2	PF08709
Domain	RIH_assoc	RYR2 RYR3	4.99e-04	6	109	2	PF08454
Domain	RIH_dom	RYR2 RYR3	4.99e-04	6	109	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	4.99e-04	6	109	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	4.99e-04	6	109	2	IPR015925
Domain	-	RYR2 RYR3	4.99e-04	6	109	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	4.99e-04	6	109	2	PF01365
Domain	Tetraspanin	TSPAN9 UPK1B TSPAN7	8.48e-04	32	109	3	IPR000301
Domain	Tetraspanin_EC2	TSPAN9 UPK1B TSPAN7	8.48e-04	32	109	3	IPR008952
Domain	EGF	FBLN7 THBD HMCN1 DLK2 NOTCH2	8.61e-04	126	109	5	PF00008
Domain	-	PCSK5 SSPOP F8 HECTD1	8.77e-04	73	109	4	2.60.120.260
Domain	GPCR_3_mtglu_rcpt	GRM3 GRM8	9.24e-04	8	109	2	IPR000162
Domain	Tetraspanin/Peripherin	TSPAN9 UPK1B TSPAN7	9.29e-04	33	109	3	IPR018499
Domain	Tetraspannin	TSPAN9 UPK1B TSPAN7	9.29e-04	33	109	3	PF00335
Domain	VWFC_1	VWCE SSPOP CCN3	1.20e-03	36	109	3	PS01208
Domain	-	TRAF6 ZFYVE16 UBOX5 UBR7 NSD3 SP140L RNF141 ARIH2 ANKIB1	1.26e-03	449	109	9	3.30.40.10
Domain	VWFC_2	VWCE SSPOP CCN3	1.41e-03	38	109	3	PS50184
Domain	VWC	VWCE SSPOP CCN3	1.41e-03	38	109	3	SM00214
Domain	Znf_RING/FYVE/PHD	TRAF6 ZFYVE16 UBOX5 UBR7 NSD3 SP140L RNF141 ARIH2 ANKIB1	1.47e-03	459	109	9	IPR013083
Domain	MIR	RYR2 RYR3	1.47e-03	10	109	2	PF02815
Domain	-	SHARPIN ZRANB1	1.47e-03	10	109	2	4.10.1060.10
Domain	MIR_motif	RYR2 RYR3	1.47e-03	10	109	2	IPR016093
Domain	MIR	RYR2 RYR3	1.47e-03	10	109	2	PS50919
Domain	MIR	RYR2 RYR3	1.47e-03	10	109	2	SM00472
Domain	E3_UB_ligase_RBR	ARIH2 ANKIB1	1.47e-03	10	109	2	IPR031127
Domain	Peripla_BP_I	GRM3 GRM8 GRIN3A	1.52e-03	39	109	3	IPR028082
Domain	Znf_FYVE_PHD	ZFYVE16 UBR7 NSD3 SP140L ANKIB1	1.71e-03	147	109	5	IPR011011
Domain	ABC_A	ABCA1 ABCA12	2.14e-03	12	109	2	IPR026082
Domain	C8	SSPOP MUC6	2.14e-03	12	109	2	PF08742
Domain	TIL	SSPOP MUC6	2.14e-03	12	109	2	PF01826
Domain	Unchr_dom_Cys-rich	SSPOP MUC6	2.52e-03	13	109	2	IPR014853
Domain	NCD3G	GRM3 GRM8	2.52e-03	13	109	2	PF07562
Domain	C8	SSPOP MUC6	2.52e-03	13	109	2	SM00832
Domain	GPCR_3_9-Cys_dom	GRM3 GRM8	2.52e-03	13	109	2	IPR011500
Domain	NHL	TENM2 TENM3	2.52e-03	13	109	2	PS51125
Domain	WW	WWOX ARHGAP39 DMD	2.60e-03	47	109	3	PF00397
Domain	WW	WWOX ARHGAP39 DMD	2.76e-03	48	109	3	SM00456
Domain	TIL_dom	SSPOP MUC6	2.93e-03	14	109	2	IPR002919
Domain	IBR	ARIH2 ANKIB1	2.93e-03	14	109	2	PF01485
Domain	IBR	ARIH2 ANKIB1	2.93e-03	14	109	2	SM00647
Domain	GPCR_3_CS	GRM3 GRM8	2.93e-03	14	109	2	IPR017979
Domain	WW_DOMAIN_1	WWOX ARHGAP39 DMD	3.29e-03	51	109	3	PS01159
Domain	WW_DOMAIN_2	WWOX ARHGAP39 DMD	3.29e-03	51	109	3	PS50020
Domain	START_lipid-bd_dom	STARD13 STARD9	3.37e-03	15	109	2	IPR002913
Domain	START	STARD13 STARD9	3.37e-03	15	109	2	PF01852
Domain	IBR_dom	ARIH2 ANKIB1	3.37e-03	15	109	2	IPR002867
Domain	START	STARD13 STARD9	3.37e-03	15	109	2	PS50848
Domain	WW_dom	WWOX ARHGAP39 DMD	3.47e-03	52	109	3	IPR001202
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	THSD4 SSPOP ADAMTS6 SBSPON MUC6 NOTCH2	2.12e-06	68	79	6	M27303
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBLN5 FN1 EFEMP2 EFEMP1	5.24e-05	37	79	4	M27134
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD4 SSPOP ADAMTS6 SBSPON	6.47e-05	39	79	4	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD4 SSPOP ADAMTS6 SBSPON	6.47e-05	39	79	4	MM15165
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBLN5 FN1 EFEMP2 EFEMP1	1.05e-04	44	79	4	M26969
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	THSD4 SSPOP ADAMTS6 SBSPON MUC6 NOTCH2	1.48e-04	143	79	6	M27275
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD4 SSPOP ADAMTS6 SBSPON MUC6	3.61e-04	109	79	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD4 SSPOP ADAMTS6 SBSPON MUC6	3.92e-04	111	79	5	M27416
Pathway	REACTOME_DISEASES_OF_METABOLISM	THSD4 SSPOP ADAMTS6 GCLM SBSPON MUC6 NOTCH2	4.96e-04	250	79	7	M27554
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	2.07e-12	6	114	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	2.07e-12	6	114	5	25930072
Pubmed	Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins.	FBLN7 FBLN5 EFEMP2 EFEMP1	1.63e-09	6	114	4	20595023
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	CALCOCO2 FBLN5 FN1 EFEMP2 TFIP11 VWCE SRRT EFEMP1 CACTIN-AS1 SHARPIN ANKIB1 GRIP2 NOTCH2 CCN3	4.80e-09	560	114	14	21653829
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	1.40e-08	24	114	5	32212159
Pubmed	Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers.	FBLN5 EFEMP2 EFEMP1	3.43e-08	3	114	3	23782690
Pubmed	A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization.	FBLN5 EFEMP2 EFEMP1	1.19e-06	7	114	3	17324935
Pubmed	Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.	CALCOCO2 TRAF6 SHARPIN	2.84e-06	9	114	3	33815386
Pubmed	Widespread macromolecular interaction perturbations in human genetic disorders.	CALCOCO2 FBLN5 ISYNA1 GGA2 LITAF EFEMP2 TFIP11 CFHR5 PNPO EFEMP1 DMD	4.06e-06	590	114	11	25910212
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PRUNE2 GGA2 WWOX ZFYVE16 INPP5B WDR11 AP4B1 NOTCH2	4.79e-06	285	114	8	34369648
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	THSD4 SSPOP HMCN1 ADAMTS6 CCN3	4.98e-06	75	114	5	20637190
Pubmed	Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.	RYR2 DMD	1.07e-05	2	114	2	26555638
Pubmed	Differential expression of fibulins in the uterosacral ligaments of women with uterine prolapse.	FBLN5 EFEMP1	1.07e-05	2	114	2	19862539
Pubmed	The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.	ABCA1 HECTD1	1.07e-05	2	114	2	29306077
Pubmed	Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13.	EFEMP2 EFEMP1	1.07e-05	2	114	2	10982184
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	1.07e-05	2	114	2	8898078
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	1.07e-05	2	114	2	14550562
Pubmed	TRAF6 regulates proliferation and differentiation of skeletal myoblasts.	TRAF6 DMD	1.07e-05	2	114	2	21131124
Pubmed	The decrease of expression of ryanodine receptor sub-type 2 is reversed by gentamycin sulphate in vascular myocytes from mdx mice.	RYR2 DMD	1.07e-05	2	114	2	19298530
Pubmed	Anti-Ro/SSA autoantibody-mediated regulation of extracellular matrix fibulins in human epithelial cells of the salivary gland.	FBLN7 HMCN1	1.07e-05	2	114	2	19229767
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	1.07e-05	2	114	2	21531043
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	1.07e-05	2	114	2	16678258
Pubmed	Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy.	TRAF6 DMD	1.07e-05	2	114	2	24163132
Pubmed	Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues.	HMCN2 HMCN1	1.07e-05	2	114	2	32035013
Pubmed	Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4.	EFEMP2 EFEMP1	1.07e-05	2	114	2	10601734
Pubmed	Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy.	RYR2 DMD	1.07e-05	2	114	2	30181262
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	1.07e-05	2	114	2	14985349
Pubmed	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	TRAF6 TAB3 SHARPIN	1.52e-05	15	114	3	23986494
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBA5 TRAF6 ARIH2 ANKIB1 HECTD1	1.59e-05	95	114	5	29643511
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	FBLN5 FN1 EFEMP2 EFEMP1 HMCN2 HMCN1	1.95e-05	167	114	6	22159717
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	FBLN5 FN1 SSPOP EFEMP1 HMCN2 HMCN1	2.53e-05	175	114	6	28071719
Pubmed	Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.	HMCN2 HMCN1	3.19e-05	3	114	2	12388743
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	3.19e-05	3	114	2	18403125
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	3.19e-05	3	114	2	29730765
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR2 RYR3	3.19e-05	3	114	2	7876312
Pubmed	Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner.	MESP1 DMD	3.19e-05	3	114	2	23642367
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR2 RYR3	3.19e-05	3	114	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR2 RYR3	3.19e-05	3	114	2	10788707
Pubmed	Comprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa.	FBLN5 EFEMP2	3.19e-05	3	114	2	22829427
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR2 RYR3	3.19e-05	3	114	2	7621815
Pubmed	Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.	FBLN5 EFEMP2	3.19e-05	3	114	2	25713297
Pubmed	Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin.	FN1 THBD	3.19e-05	3	114	2	27602495
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR2 RYR3	3.19e-05	3	114	2	10473538
Pubmed	A secreted protein promotes cleavage furrow maturation during cytokinesis.	HMCN2 HMCN1	3.19e-05	3	114	2	21215633
Pubmed	Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.	RYR2 DMD	3.19e-05	3	114	2	20615971
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR2 RYR3	3.19e-05	3	114	2	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR2 RYR3	3.19e-05	3	114	2	9204703
Pubmed	Thrombomodulin-dependent effect of factor VLeiden mutation on factor XIII activation.	F8 THBD	3.19e-05	3	114	2	21774968
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR2 RYR3	3.19e-05	3	114	2	21881589
Pubmed	A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase.	FBLN5 EFEMP2	3.19e-05	3	114	2	33239290
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR2 RYR3	3.19e-05	3	114	2	12213830
Pubmed	Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy.	RYR2 DMD	3.19e-05	3	114	2	20080623
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR2 RYR3	3.19e-05	3	114	2	9242641
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	3.19e-05	3	114	2	15024040
Pubmed	Hemicentins assemble on diverse epithelia in the mouse.	HMCN2 HMCN1	3.19e-05	3	114	2	17015624
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR2 RYR3	3.19e-05	3	114	2	25239916
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR2 RYR3	3.19e-05	3	114	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR2 RYR3	3.19e-05	3	114	2	11159936
Pubmed	A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb.	GRM3 GRM8	3.19e-05	3	114	2	7722646
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR2 RYR3	3.19e-05	3	114	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR2 RYR3	3.19e-05	3	114	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR2 RYR3	3.19e-05	3	114	2	7635066
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	PCSK5 FN1 EFEMP2 EFEMP1 TSPAN7	4.51e-05	118	114	5	21078624
Pubmed	Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.	TRAF6 TAB3 SHARPIN	5.05e-05	22	114	3	36098982
Pubmed	Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis.	FBLN5 FN1 EFEMP2	5.05e-05	22	114	3	21979435
Pubmed	ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis.	ABCA1 ABCA12	6.36e-05	4	114	2	23931754
Pubmed	GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.	STARD13 RYR2	6.36e-05	4	114	2	22328512
Pubmed	B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.	TRAF6 TNFSF13B	6.36e-05	4	114	2	10908663
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM2 TENM3	6.36e-05	4	114	2	10225957
Pubmed	A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.	EFEMP1 ADAMTS6	6.36e-05	4	114	2	26686553
Pubmed	Variant mapping and mutation discovery in inbred mice using next-generation sequencing.	PCSK5 ABCA12	6.36e-05	4	114	2	26552429
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR2 RYR3	6.36e-05	4	114	2	23413940
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR2 RYR3	6.36e-05	4	114	2	9607712
Pubmed	Isolation and characterization of two novel A20-like proteins.	TRAF6 ZRANB1	6.36e-05	4	114	2	11463333
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR2 RYR3	6.36e-05	4	114	2	23482488
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR2 RYR3	6.36e-05	4	114	2	18206662
Pubmed	Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.	HMCN2 HMCN1	6.36e-05	4	114	2	36007682
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR2 RYR3	6.36e-05	4	114	2	9384575
Pubmed	TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis.	TRAF6 DMD	6.36e-05	4	114	2	26619121
Pubmed	Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1.	FN1 CCN3	6.36e-05	4	114	2	12902636
Pubmed	TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner.	TRAF6 WDR77	6.36e-05	4	114	2	37173967
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM2 TENM3	6.36e-05	4	114	2	12000766
Pubmed	Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions.	HMCN2 HMCN1	6.36e-05	4	114	2	34504132
Pubmed	Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase.	FBLN5 EFEMP2	6.36e-05	4	114	2	19855011
Pubmed	Complexes of tetraspanins with integrins: more than meets the eye.	TSPAN9 UPK1B TSPAN7	6.60e-05	24	114	3	11739647
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM3 GRM8 GRIN3A	6.60e-05	24	114	3	35746896
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	SRRT BCL11B WDR11 ARIH2 NOTCH2	6.90e-05	129	114	5	23022380
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	WWOX KPRP TNFSF13B SEC16A	8.50e-05	70	114	4	34255829
Pubmed	Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.	RYR2 DMD	1.06e-04	5	114	2	25193470
Pubmed	Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.	TEX14 USP26	1.06e-04	5	114	2	16118233
Pubmed	Molecular and genetic mapping of the mouse mdx locus.	F8 DMD	1.06e-04	5	114	2	3243547
Pubmed	TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer.	TRAF6 TAB3	1.06e-04	5	114	2	27009840
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR2 RYR3	1.06e-04	5	114	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR2 RYR3	1.06e-04	5	114	2	19011160
Pubmed	TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding.	FBLN7 FN1	1.06e-04	5	114	2	17699513
Pubmed	Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration.	FN1 DMD	1.06e-04	5	114	2	22766125
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	1.06e-04	5	114	2	33060591
Pubmed	Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.	TNFSF13B NOTCH2	1.06e-04	5	114	2	18180309
Pubmed	WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.	WWOX LITAF	1.06e-04	5	114	2	15064722
Pubmed	WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.	TRAF6 TAB3	1.06e-04	5	114	2	19521662
Interaction	UBE2L3 interactions	UBA5 TRAF6 FN1 UBOX5 USP26 ZPR1 ARIH2 ANKIB1 HECTD1 ZRANB1 PCK2	2.92e-08	211	113	11	int:UBE2L3
Interaction	ZNF358 interactions	VWCE EFEMP1 HECTD1 NOTCH2	3.40e-06	19	113	4	int:ZNF358
Interaction	ZNF627 interactions	FBLN5 VWCE EFEMP1 NOTCH2	4.24e-06	20	113	4	int:ZNF627
Interaction	ATG9A interactions	CALCOCO2 PRUNE2 GGA2 WWOX ZFYVE16 INPP5B KPRP ITFG1 WDR11 AP4B1 ZRANB1 NOTCH2	7.64e-06	445	113	12	int:ATG9A
Interaction	SNRPD2 interactions	CAD WWOX FN1 TFIP11 TRRAP ITFG1 SRRT ARIH2 HECTD1 ZRANB1 WDR77	2.14e-05	414	113	11	int:SNRPD2
Interaction	EMILIN1 interactions	TRAF6 TRRAP UBOX5 PARS2 TAB3 WDR11	2.50e-05	103	113	6	int:EMILIN1
Interaction	OTX1 interactions	PCSK5 FBLN5 WWOX EFEMP2 KPRP M1AP ZRANB1	2.71e-05	155	113	7	int:OTX1
Interaction	TRIP13 interactions	CALCOCO2 PCSK5 FBLN5 WWOX MAD2L1BP M1AP TNFSF13B SHARPIN PLK3	2.95e-05	281	113	9	int:TRIP13
Interaction	ZNF696 interactions	CALCOCO2 FBLN5 VWCE EFEMP1 NOTCH2	3.99e-05	68	113	5	int:ZNF696
Interaction	ZSCAN2 interactions	TRRAP ZRANB1 NOTCH2	4.71e-05	13	113	3	int:ZSCAN2
Interaction	LCE3D interactions	PCSK5 EFEMP2 KPRP EFEMP1 CCN3	5.62e-05	73	113	5	int:LCE3D
Interaction	EGFL7 interactions	FBLN5 FN1 VWCE EFEMP1 NOTCH2	7.26e-05	77	113	5	int:EGFL7
Interaction	ZNF747 interactions	FBLN5 VWCE EFEMP1 NOTCH2	7.33e-05	40	113	4	int:ZNF747
Interaction	SH3PXD2A interactions	STARD13 TRAF6 RTKN TESK2 HECTD1 ZRANB1	8.46e-05	128	113	6	int:SH3PXD2A
Cytoband	Xp21.2	TAB3 DMD	1.69e-04	8	114	2	Xp21.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.69e-04	8	114	2	chr9q12
Cytoband	9p13.1	SPATA31A3 SPATA31A1	1.63e-03	24	114	2	9p13.1
Cytoband	2q34	FN1 ABCA12	2.21e-03	28	114	2	2q34
Cytoband	1p34	INPP5B GJB3	2.89e-03	32	114	2	1p34
Cytoband	2p13.1	RTKN M1AP	3.26e-03	34	114	2	2p13.1
Cytoband	9q31.1	ABCA1 GRIN3A	4.70e-03	41	114	2	9q31.1
GeneFamily	Fibulins	FBLN7 FBLN5 EFEMP2 EFEMP1 HMCN2 HMCN1	9.77e-14	8	73	6	556
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	4.81e-05	3	73	2	287
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	TAB3 SHARPIN ZRANB1	7.97e-05	21	73	3	89
GeneFamily	CD molecules\|Tetraspanins	TSPAN9 UPK1B TSPAN7	3.16e-04	33	73	3	768
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM3 GRM8	4.43e-04	8	73	2	281
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA12	1.42e-03	14	73	2	805
GeneFamily	StAR related lipid transfer domain containing	STARD13 STARD9	1.63e-03	15	73	2	759
Coexpression	NABA_ECM_GLYCOPROTEINS	THSD4 FBLN7 FBLN5 FN1 EFEMP2 VWCE SSPOP IGSF10 EFEMP1 HMCN2 HMCN1 SBSPON VWA5B1 CCN3	7.34e-14	191	110	14	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	THSD4 FBLN7 FBLN5 FN1 EFEMP2 VWCE SSPOP IGSF10 EFEMP1 HMCN2 HMCN1 SBSPON VWA5B1 CCN3	1.05e-13	196	110	14	M3008
Coexpression	NABA_CORE_MATRISOME	THSD4 FBLN7 FBLN5 FN1 EFEMP2 VWCE SSPOP IGSF10 EFEMP1 HMCN2 HMCN1 SBSPON VWA5B1 CCN3	8.23e-12	270	110	14	MM17057
Coexpression	NABA_CORE_MATRISOME	THSD4 FBLN7 FBLN5 FN1 EFEMP2 VWCE SSPOP IGSF10 EFEMP1 HMCN2 HMCN1 SBSPON VWA5B1 CCN3	1.05e-11	275	110	14	M5884
Coexpression	NABA_MATRISOME	THSD4 PCSK5 FBLN7 FBLN5 FN1 EFEMP2 OGFOD2 ADAM29 VWCE SSPOP IGSF10 EFEMP1 HMCN2 HMCN1 ADAMTS6 SBSPON TNFSF13B MUC6 VWA5B1 CCN3	6.87e-09	1008	110	20	MM17056
Coexpression	NABA_MATRISOME	THSD4 PCSK5 FBLN7 FBLN5 FN1 EFEMP2 OGFOD2 ADAM29 VWCE SSPOP IGSF10 EFEMP1 HMCN2 HMCN1 ADAMTS6 SBSPON TNFSF13B MUC6 VWA5B1 CCN3	9.24e-09	1026	110	20	M5889
Coexpression	GSE15330_WT_VS_IKAROS_KO_LYMPHOID_MULTIPOTENT_PROGENITOR_DN	GGA2 GRM8 TSPAN9 PNPO SIMC1 ANKIB1 SAC3D1	2.22e-05	200	110	7	M7058
Coexpression	GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_DN	ABCA1 LITAF ARHGAP39 RYR2 USP26 ADAMTS6 ARIH2	2.22e-05	200	110	7	M5679
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#2_top-relative-expression-ranked_500	FBLN5 FN1 EFEMP1 HMCN1 TENM3 UPK1B GRIN3A	4.99e-06	127	112	7	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k2_500
CoexpressionAtlas	dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_500	FBLN5 EFEMP2 EFEMP1 HMCN1 TENM3 UPK1B GRIN3A	2.00e-05	157	112	7	gudmap_dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k4_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500	ABCA1 GRM3 TENM2 RYR3 THBD EFEMP1 SBSPON UPK1B ERCC6L2 GRIN3A	5.96e-05	407	112	10	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_1000	FBLN5 FN1 EFEMP1 HMCN1 TENM3 ADAMTS6 UPK1B GRIN3A	7.40e-05	261	112	8	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_1000
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 RYR3 IGSF10 THBD EFEMP1 HMCN1 TENM3 DMD	4.17e-08	196	114	8	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 RYR3 IGSF10 THBD EFEMP1 HMCN1 TENM3 DMD	4.17e-08	196	114	8	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 TENM2 RYR2 GRIP2 DMD NOTCH2 CCN3	2.96e-07	171	114	7	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	STARD13 MESP1 TAB3 TENM3 SBSPON GRIP2 DMD	4.86e-07	184	114	7	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRUNE2 PCSK5 RYR2 TENM3 ADAMTS6 DMD	6.24e-07	191	114	7	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ABCA1 FBLN5 FN1 EFEMP2 RYR2 IGSF10 TENM3	8.22e-07	199	114	7	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAD RHOBTB1 RNF141 UPK1B SIMC1 PLK3	2.76e-06	153	114	6	489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 UBOX5 THBD TNFSF13B TESK2 DLK2	3.45e-06	159	114	6	709b57f992a29878cc899d760d144d36cb5cb280
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	PRUNE2 AKNAD1 RYR2 RYR3 SBSPON DMD	3.71e-06	161	114	6	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	WDR64 ADAM29 GRM8 RYR2 BCL11B DMD	3.98e-06	163	114	6	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	F8 TSPAN9 RYR3 HMCN1 TSPAN7 GRIP2	4.74e-06	168	114	6	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEMGN TAB3 PNPO M1AP GCLM NOTCH2	5.42e-06	172	114	6	4790323a072cfe76127d704665a42c09601d84be
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 FBLN5 FN1 IGSF10 HMCN1 DMD	6.18e-06	176	114	6	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 FBLN5 FN1 IGSF10 HMCN1 DMD	6.18e-06	176	114	6	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 PRUNE2 RYR3 ADAMTS6 SBSPON DMD	7.26e-06	181	114	6	25915e2500430a902db37d79a749ce2990b69810
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FBLN5 FN1 TENM2 RYR2 IGSF10 HMCN1	7.26e-06	181	114	6	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 SSPOP RYR2 RYR3 HMCN1 DMD	7.97e-06	184	114	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 SSPOP RYR2 RYR3 HMCN1 DMD	7.97e-06	184	114	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 SSPOP RYR2 RYR3 HMCN1 DMD	7.97e-06	184	114	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 FBLN5 GRM8 HMCN1 ADAMTS6 CCN3	8.48e-06	186	114	6	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN7 FBLN5 FN1 EFEMP2 THBD EFEMP1	8.48e-06	186	114	6	ff6ccfdf2509f96caa10281c29a95b432f6c6dcc
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 ISYNA1 TENM2 RYR2 DMD CCN3	8.48e-06	186	114	6	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	THSD4 PRUNE2 TSPAN9 RYR2 GRIP2 DMD	9.01e-06	188	114	6	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PCSK5 RYR2 HMCN1 ERCC6L2 NOTCH2	9.01e-06	188	114	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PCSK5 RYR2 HMCN1 ERCC6L2 NOTCH2	9.01e-06	188	114	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	PRUNE2 FN1 RYR2 RYR3 HMCN2 DMD	9.01e-06	188	114	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PCSK5 RYR2 HMCN1 ERCC6L2 NOTCH2	9.01e-06	188	114	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRUNE2 PCSK5 RYR2 ADAMTS6 DMD	9.01e-06	188	114	6	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 PRUNE2 LINC00473 RYR3 ADAMTS6 SBSPON	9.01e-06	188	114	6	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THSD4 PRUNE2 RYR3 ADAMTS6 SBSPON DMD	9.01e-06	188	114	6	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 ABCA1 TENM2 RHOBTB1 TENM3 SEC16A	9.01e-06	188	114	6	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 ISYNA1 TENM2 RYR2 DMD CCN3	9.29e-06	189	114	6	975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	PRUNE2 FN1 RYR3 HMCN2 SBSPON DMD	9.29e-06	189	114	6	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRUNE2 PCSK5 RYR2 DMD NOTCH2	9.29e-06	189	114	6	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	THSD4 PRUNE2 FN1 F8 EFEMP1 TENM3	9.57e-06	190	114	6	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	THSD4 PRUNE2 RYR3 ADAMTS6 SBSPON DMD	9.57e-06	190	114	6	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBLN7 GRM8 TSPAN9 BCL11B TENM3 GRIP2	9.57e-06	190	114	6	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PCSK5 RYR2 IGSF10 DMD NOTCH2	9.86e-06	191	114	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	THSD4 TENM2 TSPAN9 RYR2 GRIP2 DMD	9.86e-06	191	114	6	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 FBLN5 FN1 GRM8 HMCN1 ADAMTS6	9.86e-06	191	114	6	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 FBLN7 BCL11B TENM3 GRIP2 GRIN3A	9.86e-06	191	114	6	782bc7946417549ffd39e5b596db659436fa01ba
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 FN1 EFEMP2 EFEMP1 TNFSF13B CCN3	1.02e-05	192	114	6	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 FN1 EFEMP2 EFEMP1 TNFSF13B CCN3	1.02e-05	192	114	6	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 FN1 RYR3 HMCN2 SBSPON GRIN3A	1.05e-05	193	114	6	0256e8fe4a47f2e2a43ef9d19bfc047d20806d69
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FN1 EFEMP2 RYR2 IGSF10 TENM3 DMD	1.08e-05	194	114	6	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	(3)_Chondrocytes-(30)_Chondro\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	FN1 VWCE TSPAN9 EFEMP1 TENM3 TSPAN7	1.11e-05	195	114	6	f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PCSK5 FBLN5 FN1 THBD ADAMTS6 CCN3	1.11e-05	195	114	6	75db19c0371320ea5fce1d6de8c1b40b1e6a2e58
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 FN1 EFEMP2 EFEMP1 TNFSF13B CCN3	1.11e-05	195	114	6	47762d9e442fb1f6f0033e3e10f4c6e498d2c081
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	FBLN5 EFEMP2 RYR2 EFEMP1 HMCN1 TENM3	1.14e-05	196	114	6	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCSK5 LINC00473 F8 ADAMTS6 TSPAN7 CCN3	1.14e-05	196	114	6	cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 FBLN5 FN1 HMCN1 TENM3 DMD	1.14e-05	196	114	6	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 FBLN5 FN1 HMCN1 TENM3 DMD	1.14e-05	196	114	6	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRUNE2 PCSK5 FBLN5 FN1 EFEMP1 HMCN1	1.18e-05	197	114	6	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRUNE2 FN1 RYR2 HMCN2 SBSPON DMD	1.18e-05	197	114	6	bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 FBLN5 FN1 EFEMP1 TENM3 DMD	1.18e-05	197	114	6	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 FBLN5 FN1 EFEMP1 TENM3 DMD	1.18e-05	197	114	6	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 FBLN5 FN1 EFEMP2 IGSF10 EFEMP1	1.18e-05	197	114	6	86145bc1e585b4ae136e755cafd6579da2abfa65
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 FBLN5 FN1 THBD ADAMTS6 TSPAN7	1.21e-05	198	114	6	5e781583908c4ee107d986904a646a7c6b8e3591
ToppCell	COVID-19-kidney-Fibroblast-1\|kidney / Disease (COVID-19 only), tissue and cell type	THSD4 ABCA1 FBLN5 FN1 TENM3 DMD	1.25e-05	199	114	6	9503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN5 FN1 EFEMP2 IGSF10 EFEMP1 HMCN1	1.28e-05	200	114	6	c3d4ce70ab51d74c9fe2f5864e52a4a9d7570e10
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBLN5 FN1 F8 THBD ADAMTS6 TSPAN7	1.28e-05	200	114	6	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FBLN7 BCL11B TENM3 GRIP2 GRIN3A	1.28e-05	200	114	6	5ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN5 FN1 EFEMP2 IGSF10 EFEMP1 HMCN1	1.28e-05	200	114	6	137f8f9d255c66336d4f8b44b2e3f3de721f2bf0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 FBLN5 FN1 THBD HMCN2 ADAMTS6	1.28e-05	200	114	6	93e13937ec74418a697c37d56f57509fb2154780
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	PCSK5 FBLN5 FN1 HMCN1 ADAMTS6 CCN3	1.28e-05	200	114	6	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FBLN7 BCL11B TENM3 GRIP2 GRIN3A	1.28e-05	200	114	6	e79d93d55b25804f2608185168da472301b6ebca
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	THSD4 PRUNE2 PCSK5 FN1 RYR2 DMD	1.28e-05	200	114	6	67dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FBLN5 FN1 EFEMP2 IGSF10 EFEMP1 HMCN1	1.28e-05	200	114	6	25d3865aa2ced11a5ed40013e83b47d942fdf582
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PCSK5 FBLN5 FN1 HMCN1 ADAMTS6 CCN3	1.28e-05	200	114	6	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FBLN7 BCL11B TENM3 GRIP2 GRIN3A	1.28e-05	200	114	6	320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STARD13 EFEMP1 HMCN2 SBSPON GRIN3A	1.76e-05	125	114	5	d05556ea185c15815a4f8643f1c01185badbeece
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-2\|TCGA-Bladder / Sample_Type by Project: Shred V9	PRUNE2 RYR3 IGSF10 HMCN2 DMD	3.14e-05	141	114	5	1baa054c2ae3b446d1954244b7fbf8af824ef345
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	THSD4 TEX14 BCL11B DLK2 SAC3D1	3.71e-05	146	114	5	159dd157a74f3c27dc1a1dcbbf0ed8f9462cac9e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 PCSK5 FN1 ADAMTS6 STARD9	4.79e-05	154	114	5	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR64 ABCA12 RYR2 RYR3 HMCN1	5.74e-05	160	114	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR64 ABCA12 RYR2 RYR3 HMCN1	5.74e-05	160	114	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STARD13 FBLN5 ADAMTS6 SBSPON	5.87e-05	82	114	4	42017b8ace6f142a8358213c95a2632226c3a867
ToppCell	343B-Epithelial_cells-Epithelial-H_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ISYNA1 EFEMP2 GJB3 HMCN1 DLK2	5.91e-05	161	114	5	da9eecf919866a9c579d7a707a996cf335213134
ToppCell	343B-Epithelial_cells-Epithelial-H_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ISYNA1 EFEMP2 GJB3 HMCN1 DLK2	5.91e-05	161	114	5	d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ISYNA1 ARHGEF39 SBSPON GRIP2 DMD	6.27e-05	163	114	5	8f24cef152f5965727bbeee116bd26c75cbba82a
ToppCell	Endothelial-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	AKNAD1 RYR2 SBSPON TSPAN7 DLK2	7.03e-05	167	114	5	6a03d16165e0b003092c39972928981abd4a75aa
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 EFEMP1 TENM3 UPK1B MUC6	7.03e-05	167	114	5	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 EFEMP1 TENM3 UPK1B MUC6	7.03e-05	167	114	5	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ISYNA1 HEMGN VWCE RYR3 PNPO	7.23e-05	168	114	5	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEMGN MAD2L1BP TAB3 PNPO GCLM	7.64e-05	170	114	5	b180ec9a1b79025a180c8559c27c31272410dea8
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEMGN MAD2L1BP TAB3 PNPO GCLM	7.64e-05	170	114	5	37c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 F8 THBD EFEMP1 TSPAN7	7.64e-05	170	114	5	4848965bc7e9356c6601bb41eeea1553d2eea87e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RYR3 EFEMP1 ADAMTS6 GRIP2 GRIN3A	7.64e-05	170	114	5	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TRAF6 TNFSF13B CAMTA1 PLK3	7.74e-05	88	114	4	142d2e00ef19c0ad011a21945bf1111271056eae
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM2 RYR3 HMCN2 SBSPON GRIN3A	7.86e-05	171	114	5	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM2 RYR3 HMCN2 SBSPON GRIN3A	7.86e-05	171	114	5	09e653973962fb884878089d281f0947f7a285f6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 ADAMTS6 STARD9 GRIN3A CD200R1L	8.08e-05	172	114	5	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 ADAMTS6 STARD9 GRIN3A CD200R1L	8.08e-05	172	114	5	553701349444eb366df3c11f54bb093434f153c6
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	PRUNE2 RYR2 RYR3 SBSPON DMD	8.30e-05	173	114	5	a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD4 GRM3 GRM8 RYR3 RHOBTB1	8.53e-05	174	114	5	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRUNE2 FBLN5 RTKN F8 RYR3	8.76e-05	175	114	5	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRUNE2 FBLN5 RTKN F8 RYR3	8.76e-05	175	114	5	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 BCL11B TENM3 GRIP2 GRIN3A	9.00e-05	176	114	5	322259a35f5c97d73ce7f75835dcdb5c954c91f8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 FN1 EFEMP2 EFEMP1 CCN3	9.00e-05	176	114	5	fcf324e6402819683f95e0dd94bf1f777c7f4c76
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 TSPAN9 RHOBTB1 HMCN1 TSPAN7	9.00e-05	176	114	5	7292e014b8f697f0c2e9f47c48333de95cb44a69
Disease	pantothenate measurement	ABCA1 CAD TENM2	2.49e-06	8	106	3	EFO_0021034
Disease	Cutis Laxa, Autosomal Recessive, Type I	FBLN5 EFEMP2	1.28e-05	2	106	2	C0268351
Disease	Cutis laxa, recessive, type I	FBLN5 EFEMP2	1.28e-05	2	106	2	C0432336
Disease	amino acid measurement	WWOX ZFYVE16 ABCA12 LITAF TSPAN9 RYR2 RYR3 M1AP GRIP2 CAMTA1 AP4B1	3.35e-05	678	106	11	EFO_0005134
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	3.83e-05	3	106	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	3.83e-05	3	106	2	DOID:8545 (implicated_via_orthology)
Disease	cutis laxa (implicated_via_orthology)	FBLN5 EFEMP2	3.83e-05	3	106	2	DOID:3144 (implicated_via_orthology)
Disease	Cutis laxa, autosomal recessive	FBLN5 EFEMP2	1.27e-04	5	106	2	cv:C3665335
Disease	periodontitis	THSD4 ABCA1 WDR36 TENM2 DMD CAMTA1	1.58e-04	223	106	6	EFO_0000649
Disease	Cutis Laxa	FBLN5 EFEMP2	1.90e-04	6	106	2	C0010495
Disease	Glaucoma	WDR36 EFEMP1	1.90e-04	6	106	2	cv:C0017601
Disease	Colorectal Carcinoma	CALCOCO2 ABCA1 CAD FN1 ABCA12 ADAM29 MLH3 BCL11B EFEMP1 DMD	2.23e-04	702	106	10	C0009402
Disease	triacylglycerol 58:6 measurement	TRAF6 TENM2	3.53e-04	8	106	2	EFO_0010440
Disease	urate measurement, bone density	THSD4 WDR64 WWOX TENM2 BCL11B RHOBTB1 TNFSF13B ARIH2 SEC16A	4.01e-04	619	106	9	EFO_0003923, EFO_0004531
Disease	upper face morphology measurement	BCL11B EFEMP1 SP140L CCN3	4.22e-04	97	106	4	EFO_0010949
Disease	Thrombophilia	F8 THBD	4.53e-04	9	106	2	C0398623
Disease	temporomandibular joint disorder	TSPAN9 DMD	5.65e-04	10	106	2	EFO_0005279
Disease	unipolar depression, sex interaction measurement	FBLN5 WWOX ADAM29	8.28e-04	51	106	3	EFO_0003761, EFO_0008343
Disease	response to efavirenz, virologic response measurement	GRM8 IGSF10 BCL11B	1.20e-03	58	106	3	EFO_0006904, EFO_0006906
Disease	Tinnitus	ADAM29 BCL11B EFEMP1 SPATA31A1	1.26e-03	130	106	4	HP_0000360
Disease	glycerate measurement	RYR3 HMCN1	1.30e-03	15	106	2	EFO_0021029
Disease	diverticular disease	STARD13 PCSK5 TSPAN9 EFEMP1 CCN3	1.65e-03	236	106	5	EFO_0009959
Disease	common carotid intimal medial thickness	GRM8 RYR3 ERCC6L2	1.83e-03	67	106	3	EFO_0004860
Disease	Age-related macular degeneration	FBLN5 HMCN1	1.88e-03	18	106	2	cv:C0242383
Disease	susceptibility to mononucleosis measurement	WDR36 RYR2 DMD	1.99e-03	69	106	3	EFO_0008403
Disease	lung cancer	TENM2 ZRANB1	2.57e-03	21	106	2	MONDO_0008903
Disease	Lung diseases	PCSK5 FBLN5 EFEMP2	2.82e-03	78	106	3	C0024115
Disease	Glioblastoma	FN1 SRRT NOTCH2	2.92e-03	79	106	3	C0017636
Disease	Colorectal Neoplasms	CALCOCO2 ABCA1 ABCA12 MLH3 EFEMP1	3.30e-03	277	106	5	C0009404
Disease	unipolar depression, neuroticism measurement	WWOX TSPAN9	3.35e-03	24	106	2	EFO_0003761, EFO_0007660
Disease	Giant Cell Glioblastoma	FN1 SRRT NOTCH2	3.48e-03	84	106	3	C0334588

Protein segments in the cluster

Peptide	Gene	Start	Entry
QCDGMRICEQAPQQA	USP26	741	Q9BXU7
CGRIQCENVTEIPNM	ADAM29	551	Q9UKF5
QAEMCLPCCSPQQGS	CAMTA1	816	Q9Y6Y1
PGIDNMCLNTSDLQC	ABCA12	1811	Q86UK0
TSQCSDPCAPNEMKN	GRM3	506	Q14832
NQVNLASCCVMPPDL	GCLM	186	P48507
MQNPSPACQCSSDKI	ABCA1	1456	O95477
AINTLCKDCSDPNPM	AP4B1	86	Q9Y6B7
NPENCCQRSGVQMPT	ANKIB1	276	Q9P2G1
VSCMAQDCPLRTPED	ARIH2	181	O95376
NNLVNVPLCVDMCLN	DMD	3166	P11532
ASKPRMNEGTPQCAC	CACTIN-AS1	196	Q8N1I8
CLETVRPPSMQQCES	ADAMTS6	1056	Q9UKP5
MELSCPGSRCPVQEQ	ARHGEF39	1	Q8N4T4
MAPNCLRCQSDDPRV	ARHGAP39	1041	Q9C0H5
LCQRVSFCTDMDPEP	ISYNA1	436	Q9NPH2
TFLDRPIQMCCPSCN	LITAF	86	Q99732
FQCERNPCPMDSRPC	FBLN7	316	Q53RD9
NCPAALERETDPCSM	MUC6	566	Q6W4X9
CETFVDVCPQMPCLN	NOTCH2	1301	Q04721
AVRNSLCPMCCREPD	OGFOD2	311	Q6N063
EPLNASEAFCPRDCM	MAD2L1BP	41	Q15013
RPRDNPMCLKCDLQE	M1AP	251	Q8TC57
RMQGPSLPCLDVNEC	HMCN2	4746	Q8NDA2
QELSNEENCCAPIPM	DOP1B	1136	Q9Y3R5
NNFDPACCPAKMILD	KIAA2026	541	Q5HYC2
SQPVLMDINAVLCCP	CD200R1L	41	Q6Q8B3
PAEDQCQTCPMNSLL	PCSK5	1481	Q92824
NSRFCAPARQCPIMD	PCK2	421	Q16822
ECDTRQSLQQSMPPC	MLH3	1436	Q9UHC1
CPACQNMLFESIQEG	MKNK2	311	Q9HBH9
MVSGQNCCEEKRNPS	GGA2	386	Q9UJY4
TENMERNCRAPCNIQ	F8	1911	P00451
RNCRAPCNIQMEDPT	F8	1916	P00451
QCPDIGEANAMCLAT	PNPO	71	Q9NVS9
LSCELCPLDQRPNMN	GRM8	551	O00222
CPLDQRPNMNRTGCQ	GRM8	556	O00222
CQDMKEPEDNSPNTC	HEMGN	191	Q9BXL5
KPCQGSDLEMRNCQN	HMCN1	4566	Q96RW7
SDLEMRNCQNKPCPV	HMCN1	4571	Q96RW7
SQIQRCNTDMCPVDG	HMCN1	4801	Q96RW7
LCPAGQLCLDPMTND	GRIN3A	536	Q8TCU5
LMSDNVDRCFETCPP	HECTD1	36	Q9ULT8
DRSPSSAQQCPLCMN	IGSF10	246	Q6WRI0
SAQQCPLCMNPRTSK	IGSF10	251	Q6WRI0
PDPDLLTCGQCQMNF	BCL11B	51	Q9C0K0
TRLCMVRPCEQEPEQ	CCN3	241	P48745
RACCFQAVPPSNMKQ	LINC00473	96	A8K010
RTNTNVNCPIECFMP	FN1	2451	P02751
VNCPIECFMPLDVQA	FN1	2456	P02751
RQDCAEMTAPSPSCA	AKNAD1	591	Q5T1N1
EQQQMQPLCFNCPIC	CALCOCO2	411	Q13137
PRCLDPCVVSEENMN	CFHR5	501	Q9BXR6
KDICSRMQFCQPDPS	INPP5B	496	P32019
VVQAPCEMQIVDCPA	KPRP	36	Q5T749
NRMALCVSNCPEEQL	SLC44A3	111	Q8N4M1
CEVNVDDCLMRPCAN	DLK2	171	Q6UY11
PACQDQECQVSMLPA	DLK2	351	Q6UY11
LEMPRQPDCQECRGT	ERCC6L2	736	Q5T890
RISDNRCMCPAENPG	FBLN5	326	Q9UBX5
NCPMEDAVQILRQCE	GRIP2	616	Q9C0E4
PNNRSCVDVNECDMG	EFEMP2	196	O95967
FNMPRLVQCANVAPC	GJB3	156	O75712
NASLPNDTQRAMEPC	SLC22A8	81	Q8TCC7
TCPDMCPAAERAQRE	SAC3D1	56	A6NKF1
NNPERAEMCCTALNS	RYR2	3256	Q92736
PNAPACMERQLEAAR	WDR77	21	Q9BQA1
LTPENRCVCPVSNAM	EFEMP1	371	Q12805
VCCRLAAQPLCMTQP	RTKN	296	Q9BST9
DLSQMNCPACQGPLT	PARS2	286	Q7L3T8
PMTCTACQRPVASQD	UBOX5	521	O94941
QPGQCCTDNPVMLDA	STARD13	211	Q9Y3M8
MFCNQTACPADCDPN	THBD	406	P07204
QAPDPCLMARETQNQ	TEX14	586	Q8IWB6
CLMARETQNQDAPCP	TEX14	591	Q8IWB6
QEQCQDTMLPVCDHP	PRUNE2	1956	Q8WUY3
QPCTAQCPENMLFRS	SSPOP	2881	A2VEC9
NCTMGDPLQERPCNL	SSPOP	3916	A2VEC9
NHPALNRCEQCEMPR	TAB3	696	Q8N5C8
VPQCRVPLETCMLAN	SPATA31A6	951	Q5VVP1
PQCRVPLETCMLANL	SPATA31A7	956	Q8IWB4
RALSCPSQTMQCQLP	SIMC1	226	Q8NDZ2
NAPDRPGCEMCSTQR	SHARPIN	361	Q9H0F6
AECDVPMNQCIDPSC	TENM2	631	Q9NT68
MGTNEAACLLDNPLC	RHOBTB1	251	O94844
CPQERNPSECKSQEM	STARD9	2011	Q9P2P6
NPSECKSQEMLNPNR	STARD9	2016	Q9P2P6
CPDDCPAQMQTRTQA	MESP1	166	Q9BRJ9
QCCQESEVLERQMCP	SP140L	456	Q9H930
NTCEYPNEDEMPNRC	SRRT	626	Q9BXP5
PQCRVPLETCMLANL	SPATA31A3	956	Q5VYP0
CALRNCIAFMPPAEQ	PLK3	436	Q9H4B4
STNCPECNAPAQTNM	ZPR1	256	O75312
VCVDCQPPAMNSVSL	SBSPON	201	Q8IVN8
PQCRVPLETCMLANL	SPATA31A1	956	Q5TZJ5
QPPDNMETLCAPQVC	SEC16A	661	O15027
PQCRVPLETCMLANL	SPATA31A5	956	Q5VU36
MLLNFQLGENCPCPE	RYR3	1876	Q15413
SMKPNPQCDDRNCRK	UBA5	296	Q9GZZ9
RNCPICRLQMTGANE	RNF141	186	Q8WVD5
EFALMDCPQCQRPFQ	TRAF6	156	Q9Y4K3
CQNGEVECSFMPCPE	VWCE	526	Q96DN2
FNNCCRCMPSPEAQS	WWOX	376	Q9NZC7
MDPDCCLQSSCQNQP	TENM3	796	Q9P273
NPCGLESECLNRMLQ	NSD3	1106	Q9BZ95
NCVTVCNMENLDPLG	CAD	611	P27708
DRLMLQDNCCGVNGP	UPK1B	151	O75841
RENNQIGPMLRLCCQ	ZNFX1	1251	Q9P2E3
PPESGDFQEMVCQAC	UBR7	171	Q8N806
NVPCNNASCEEARRM	ITFG1	366	Q8TB96
RPNDIENCDMGPCAK	THSD4	781	Q6ZMP0
VRPFSMVCCPVNENA	WDR11	356	Q9BZH6
PPDFLQLTFNCCNMD	TESK2	281	Q96S53
QLTFNCCNMDPKLRP	TESK2	286	Q96S53
RCIQNMPETLPNNSC	TNFSF13B	231	Q9Y275
PPSCCMNETDCNPQD	TSPAN7	171	P41732
ALNCFVEAMSQCVPP	TRRAP	2671	Q9Y4A5
EECERRMQPDCSNPL	TFIP11	381	Q9UBB9
RMQPDCSNPLTLDEC	TFIP11	386	Q9UBB9
SQQAAKCIPAMVCPE	ZRANB1	336	Q9UGI0
GENTVPDRCCMENSQ	TSPAN9	161	O75954
PDSEAPNCMNCQVKF	ZFYVE16	746	Q7Z3T8
MLNFCPDLQSVQPCL	VWA5B1	341	Q5TIE3
QPTDNPTMDLLRVNC	WDR64	636	B1ANS9
NSVPQDICCMAADGR	WDR36	121	Q8NI36
QCAMKDPQNCALPAL	ZSWIM4	761	Q9H7M6
CLGACVNAPMVQIND	NDUFV2	176	P19404