Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 ZNF624 ZNF217 ZNF90 STOX1 SNAPC3 SOX8 TET3 ZFY ZNF404 ZNF331	1.94e-06	1459	77	19	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 ZNF624 ZNF217 ZNF90 SNAPC3 SOX8 TET3 ZFY ZNF331	3.99e-06	1244	77	17	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 ZNF624 ZNF217 ZNF90 SNAPC3 SOX8 TET3 ZFY ZNF331	5.32e-06	1271	77	17	GO:0000987
GeneOntologyMolecularFunction	carbon-sulfur lyase activity	CENPVL2 CENPVL3 CENPVL1	2.98e-05	16	77	3	GO:0016846
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 ZNF624 ZNF217 ZNF90 SOX8 ZFY ZNF404 ZNF331	7.98e-05	1412	77	16	GO:0000981
HumanPheno	Cor pulmonale	TGFB1 FLNA MAP3K20	1.64e-05	15	18	3	HP:0001648
Domain	Znf_C2H2/integrase_DNA-bd	RAG1 ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	5.05e-10	694	70	17	IPR013087
Domain	Znf_C2H2-like	RAG1 ZBTB49 ZNF140 ZNF609 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	5.12e-10	796	70	18	IPR015880
Domain	ZnF_C2H2	RAG1 ZBTB49 ZNF140 ZNF609 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	6.51e-10	808	70	18	SM00355
Domain	ZINC_FINGER_C2H2_2	ZBTB49 ZNF140 ZNF609 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	2.69e-09	775	70	17	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB49 ZNF140 ZNF609 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	2.80e-09	777	70	17	PS00028
Domain	-	RAG1 ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	3.11e-09	679	70	16	3.30.160.60
Domain	zf-C2H2	ZBTB49 ZNF140 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	4.16e-09	693	70	16	PF00096
Domain	Znf_C2H2	ZBTB49 ZNF140 ZNF609 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	4.76e-09	805	70	17	IPR007087
Domain	zf-C2H2_6	ZBTB49 ZNF140 ZNF473 ZNF195 ZNF521 ZNF624 ZNF90 ZNF404 ZNF331	2.53e-06	314	70	9	PF13912
Domain	KRAB	ZNF140 ZNF473 ZNF41 ZNF195 ZNF624 ZNF90 ZNF404 ZNF331	5.65e-05	358	70	8	PS50805
Domain	KRAB	ZNF140 ZNF473 ZNF41 ZNF195 ZNF624 ZNF90 ZNF404 ZNF331	5.65e-05	358	70	8	PF01352
Domain	KRAB	ZNF140 ZNF473 ZNF41 ZNF195 ZNF624 ZNF90 ZNF404 ZNF331	6.98e-05	369	70	8	SM00349
Domain	KRAB	ZNF140 ZNF473 ZNF41 ZNF195 ZNF624 ZNF90 ZNF404 ZNF331	7.12e-05	370	70	8	IPR001909
Domain	-	ATP12A ATP2B4	1.61e-03	16	70	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP12A ATP2B4	1.61e-03	16	70	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP12A ATP2B4	1.82e-03	17	70	2	IPR006068
Domain	Cation_ATPase_C	ATP12A ATP2B4	1.82e-03	17	70	2	PF00689
Domain	Cation_ATPase_N	ATP12A ATP2B4	2.04e-03	18	70	2	PF00690
Domain	Cation_ATPase_N	ATP12A ATP2B4	2.04e-03	18	70	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP12A ATP2B4	2.27e-03	19	70	2	IPR004014
Domain	TPR-contain_dom	OGT RGPD1 PDCD11 TMTC2	2.43e-03	150	70	4	IPR013026
Domain	TPR_1	OGT RGPD1 TMTC2	4.69e-03	90	70	3	PF00515
Domain	TPR_1	OGT RGPD1 TMTC2	4.69e-03	90	70	3	IPR001440
Domain	-	OGT RGPD1 PDCD11 TMTC2	7.60e-03	207	70	4	1.25.40.10
Domain	ATPase_P-typ_cyto_domN	ATP12A ATP2B4	7.61e-03	35	70	2	IPR023299
Domain	P_typ_ATPase	ATP12A ATP2B4	8.03e-03	36	70	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP12A ATP2B4	8.03e-03	36	70	2	IPR018303
Domain	ATPASE_E1_E2	ATP12A ATP2B4	8.03e-03	36	70	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP12A ATP2B4	8.47e-03	37	70	2	IPR008250
Domain	E1-E2_ATPase	ATP12A ATP2B4	8.47e-03	37	70	2	PF00122
Pubmed	Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.	CENPVL2 CENPVL3 CENPVL1	2.08e-07	6	77	3	27250503
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CASP8AP2 FLNA ZNF609 HIVEP1 OGT RGPD1 ZNF217 SOX8 TANGO6	3.77e-07	418	77	9	34709266
Pubmed	TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.	TGFB1 RAG1	4.84e-06	2	77	2	18669656
Pubmed	Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates.	RAG1 F8	4.84e-06	2	77	2	35508619
Pubmed	TET3-OGT interaction increases the stability and the presence of OGT in chromatin.	OGT TET3	4.84e-06	2	77	2	24304661
Pubmed	A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.	TGFB1 TET3	4.84e-06	2	77	2	32023451
Pubmed	TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer.	OGT TET3	4.84e-06	2	77	2	34948036
Pubmed	Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.	TGFB1 RAG1	4.84e-06	2	77	2	22194977
Pubmed	Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer.	OGT SNAP29	4.84e-06	2	77	2	30555541
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	TGFB1 RAG1 ZNF195 ZNF624	1.05e-05	61	77	4	8662221
Pubmed	Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-β production.	TGFB1 FLNA	1.45e-05	3	77	2	34174537
Pubmed	Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells.	RAG1 IFTAP	1.45e-05	3	77	2	22984564
Pubmed	T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine.	TGFB1 RAG1	1.45e-05	3	77	2	21757379
Pubmed	PARP-1 regulates expression of TGF-β receptors in T cells.	TGFB1 RAG1	1.45e-05	3	77	2	23940283
Pubmed	Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation.	RAG1 IFTAP	1.45e-05	3	77	2	15971274
Pubmed	von Willebrand factor and transforming growth factor-beta modulate immune response against coagulation factor VIII in FVIII-deficient mice.	TGFB1 F8	1.45e-05	3	77	2	17376515
Pubmed	Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.	TGFB1 RAG1	1.45e-05	3	77	2	19604492
Pubmed	TET2 promotes histone O-GlcNAcylation during gene transcription.	OGT TET3	1.45e-05	3	77	2	23222540
Pubmed	miR-488-5p mitigates hepatic stellate cell activation and hepatic fibrosis via suppressing TET3 expression.	TGFB1 TET3	1.45e-05	3	77	2	36001230
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SLC38A2 CASP8AP2 ZNF609 MTUS1 JADE3 PDCD11 DIDO1 ADCY9	2.28e-05	529	77	8	14621295
Pubmed	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.	OGT TET3	2.89e-05	4	77	2	23353889
Pubmed	Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).	OGT TET3	2.89e-05	4	77	2	25568311
Pubmed	Lack of association between FXIII-Val34Leu, FVII-323 del/ins, and transforming growth factor beta1 (915G/T) gene polymorphisms and bronchopulmonary dysplasia: a single-center study.	TGFB1 F8	2.89e-05	4	77	2	19778283
Pubmed	Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).	OGT TET3	2.89e-05	4	77	2	24394411
Pubmed	T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis.	RAG1 THEMIS	2.89e-05	4	77	2	31932808
Pubmed	In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.	SLC38A2 RAG1	2.89e-05	4	77	2	33636132
Pubmed	DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.	RAG1 TET3	4.82e-05	5	77	2	36880575
Pubmed	Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.	RAG1 THEMIS	4.82e-05	5	77	2	19597499
Pubmed	Loss of TET2 and TET3 in regulatory T cells unleashes effector function.	RAG1 TET3	4.82e-05	5	77	2	31043609
Pubmed	Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation.	RAG1 PDP2	4.82e-05	5	77	2	30150402
Pubmed	Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.	TGFB1 RAG1	4.82e-05	5	77	2	30850474
Pubmed	ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1.	TGFB1 RAG1	4.82e-05	5	77	2	33911034
Pubmed	CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.	RAG1 TET3	4.82e-05	5	77	2	35304452
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF140 ZNF41 ZNF195 ZNF624 ZNF90	5.27e-05	181	77	5	37372979
Pubmed	TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.	TGFB1 RAG1	7.22e-05	6	77	2	23932572
Pubmed	Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.	TGFB1 RAG1	7.22e-05	6	77	2	21435587
Pubmed	TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.	TGFB1 RAG1	7.22e-05	6	77	2	24115907
Pubmed	O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation.	OGT SNAP29	7.22e-05	6	77	2	25419848
Pubmed	Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.	RAG1 SIRPB1	1.01e-04	7	77	2	23293079
Pubmed	Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.	TGFB1 RAG1	1.01e-04	7	77	2	10945464
Pubmed	SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity.	SLC38A2 RAG1	1.01e-04	7	77	2	37407815
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TGFB1 KIAA0319 SLC38A2 IARS2 PDE4DIP ZW10 ATP12A ATP2B4 FKBP3 ADCY9	1.15e-04	1061	77	10	33845483
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	FLNA ZNF473 RGPD1 NKAPL FKBP3	1.19e-04	215	77	5	35973513
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF609 HIVEP1 OGT RGPD1 ZNF521 ZNF217	1.31e-04	351	77	6	38297188
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLC38A2 FLNA OGT ANK3 ZNF473 GAS2L3 DIDO1 CCDC77 VPS13B SNAP29	1.37e-04	1084	77	10	11544199
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ZNF140 HIVEP1 ANK3 MAP3K20 DIDO1 IP6K1	1.53e-04	361	77	6	26167880
Pubmed	Praja1, a novel gene encoding a RING-H2 motif in mouse development.	FLNA ZFY	1.72e-04	9	77	2	9393880
Pubmed	Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.	F8 ZFY	1.72e-04	9	77	2	7590750
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SLC38A2 CPNE8 ANK3 ATP2B4 ADCY9 SNAP29	1.93e-04	377	77	6	38117590
Pubmed	Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.	RAG1 SIRPB1	2.15e-04	10	77	2	28783664
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FLNA OGT ANK3 PDCD11 DIDO1 TAF2 SNAP29	2.18e-04	549	77	7	38280479
Pubmed	Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).	TGFB1 FLNA	2.63e-04	11	77	2	25336651
Pubmed	Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.	FLNA OGT	2.63e-04	11	77	2	33849069
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIAA0319 OGT ANK3 PDE4DIP RGPD1 WDR81 DIDO1 SIRPB1 ATP2B4	2.76e-04	963	77	9	28671696
Pubmed	Phenotypic annotation of the mouse X chromosome.	FLNA OGT JADE3	3.42e-04	61	77	3	20548051
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	ANK3 RGPD1	3.71e-04	13	77	2	31427429
Pubmed	IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.	TGFB1 RAG1	3.71e-04	13	77	2	18997793
Pubmed	Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.	TGFB1 RAG1	3.71e-04	13	77	2	28844693
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	SLC38A2 CASP8AP2 PDP2 ZNF624	3.80e-04	153	77	4	10718198
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SLC38A2 CASP8AP2 CPNE8 IARS2 ANK3 ASCC2 PDCD11 CCDC77 ATP2B4 VPS13B ADCY9	4.20e-04	1487	77	11	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	BDP1 ATRN ZNF609 OGT ANK3 PCDHGB1 ENPP5 TET3 VPS13B SNAP29 ZNF331	4.25e-04	1489	77	11	28611215
Pubmed	Pigmentation-related genes and their implication in malignant melanoma susceptibility.	ATRN VPS13B	4.33e-04	14	77	2	19320733
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	F8 ZFY	4.33e-04	14	77	2	8432533
Pubmed	Molecular phylogenetics and the origins of placental mammals.	RAG1 ZFY	4.99e-04	15	77	2	11214319
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN OGT ANK3 ZNF473 PDE4DIP ZNF521 ZNF624 ENPP5 REV3L ZNF331	5.30e-04	1285	77	10	35914814
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	TGFB1 BDP1 CASP8AP2 FLNA ANK3 PDE4DIP ASCC2 SIRPB1 REV3L ZNF331	5.56e-04	1293	77	10	15342556
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	PDP2 DIDO1 IP6K1 FKBP3	5.77e-04	171	77	4	36629882
Pubmed	A human MAP kinase interactome.	TGFB1 CASP8AP2 FLNA HIVEP1 ANK3 PLEKHA6	7.41e-04	486	77	6	20936779
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF609 OGT MTUS1 ACTL6B SIRPB1 TAF2 REV3L ADCY9 SNAP29	7.97e-04	1116	77	9	31753913
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	FLNA CPNE8 GAS2L3 MAP3K20 ASCC2 PDCD11 DIDO1 CCDC77 ATP2B4 FKBP3	8.72e-04	1371	77	10	36244648
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF195 ZNF624	8.96e-04	20	77	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF195 ZNF624	8.96e-04	20	77	2	2542606
Pubmed	Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.	ASCC2 SNAP29	8.96e-04	20	77	2	16009131
Pubmed	BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma.	OGT DIDO1	8.96e-04	20	77	2	32509391
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FLNA WDR81 ZNF521	9.04e-04	85	77	3	15449545
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	TGFB1 RAG1 ZNF624 DIDO1 REV3L	1.11e-03	351	77	5	20453000
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	CASP8AP2 PAM FKBP3	1.14e-03	92	77	3	15840729
Pubmed	Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.	TGFB1 ZBTB49	1.19e-03	23	77	2	30779601
Pubmed	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	PDE4DIP SNAP29	1.19e-03	23	77	2	22792062
Pubmed	Human transcription factor protein interaction networks.	ZNF609 HIVEP1 OGT RGPD1 ZNF521 PDCD11 DIDO1 ZNF217 TAF2 TANGO6	1.19e-03	1429	77	10	35140242
Pubmed	The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.	HIVEP1 SOX8	1.29e-03	24	77	2	16582099
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	FLNA OGT JADE3 PDCD11	1.33e-03	214	77	4	22199357
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	FLNA ANK3 PLEKHA6 ATP2B4 ADCY9 SNAP29	1.60e-03	565	77	6	25468996
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KIAA0319 ZNF609 DIDO1	1.62e-03	104	77	3	9205841
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	SLC38A2 FLNA ZW10 VPS13B ADCY9 SNAP29	1.64e-03	568	77	6	37774976
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	CPNE8 TAF2 PLEKHA6 ATP2B4 VPS13B ADCY9	1.66e-03	569	77	6	30639242
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ATRN VPS13B ADCY9	1.66e-03	105	77	3	9628581
Pubmed	Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.	FLNA NMBR	1.76e-03	28	77	2	20736409
Pubmed	Identification of Arx transcriptional targets in the developing basal forebrain.	PDE4DIP SOX8	1.76e-03	28	77	2	18799476
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	ZNF521 SOX8	1.89e-03	29	77	2	31491374
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP12A ATP2B4	1.89e-03	29	77	2	15071553
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	ZNF609 HIVEP1 IFTAP ZNF217 TANGO6	1.93e-03	398	77	5	35016035
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNA HIVEP1 ANK3 ZNF41 PDE4DIP ASCC2	2.01e-03	591	77	6	15231748
Pubmed	Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.	TGFB1 ATP12A	2.02e-03	30	77	2	2842249
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	JADE3 ASCC2	2.02e-03	30	77	2	30480076
Pubmed	Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.	ZNF521 PRDM12	2.16e-03	31	77	2	36476860
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	OGT MAP3K20 IFI44 DIDO1 ZW10	2.19e-03	410	77	5	26949251
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	HIVEP1 ZNF217 CCDC77	2.21e-03	116	77	3	30804394
Cytoband	Xp11.22	CENPVL2 CENPVL3 CENPVL1	1.06e-04	54	77	3	Xp11.22
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	CENPVL2 CENPVL3 JADE3 ZNF41 CENPVL1	4.43e-04	377	77	5	chrXp11
Cytoband	Ensembl 112 genes in cytogenetic band chr11p12	RAG1 IFTAP	4.66e-04	19	77	2	chr11p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB49 ZNF140 ZNF609 HIVEP1 ZBTB7C ZNF473 ZSCAN5DP ZNF41 ZNF195 ZNF521 PRDM12 ZNF624 ZNF217 ZNF90 ZFY ZNF404 ZNF331	3.64e-12	718	50	17	28
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FCER2 PCDHGB1 ZNF521 NKAPL VPS13B	1.03e-05	166	77	5	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF140 ZNF624 DIDO1 CCDC77 ADCY9	1.48e-05	179	77	5	5be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 PDE4DIP MAP3K20 PAM ATP2B4	1.60e-05	182	77	5	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CASP8AP2 JADE3 ZNF41 TET3 VPS13B	1.78e-05	186	77	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ANK3 PDE4DIP PAM ATP2B4 ZNF331	1.92e-05	189	77	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	ANK3 PDE4DIP PAM ATP2B4 ZNF331	1.97e-05	190	77	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	CPNE8 ZBTB7C IFI44 ZNF521 TMTC2	1.97e-05	190	77	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF609 ANK3 TMTC2 VPS13B ADCY9	2.28e-05	196	77	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF609 ANK3 TMTC2 VPS13B ADCY9	2.40e-05	198	77	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 OGT ANK3 IFI44 VPS13B	2.46e-05	199	77	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	COVID-19_Moderate-CD4+_CTL\|COVID-19_Moderate / disease group, cell group and cell class	TGFB1 FLNA THEMIS PAM ATP2B4	2.52e-05	200	77	5	a9c73559e2c9fda1b065bfb5ce84978995505924
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	FLNA NBPF10 IFI44 ENPP5 ATP2B4	2.52e-05	200	77	5	2281debd86e5d92e8fe0397aec9ef670800f7471
Disease	factor VIII deficiency (is_implicated_in)	TGFB1 F8	3.10e-04	11	71	2	DOID:12134 (is_implicated_in)
Disease	hepcidin:ferritin ratio	THEMIS STON1 IFTAP	3.20e-04	55	71	3	EFO_0007901
Disease	alcohol and nicotine codependence	HIVEP1 RGPD1	4.38e-04	13	71	2	EFO_0004776
Disease	osteochondrodysplasia (is_implicated_in)	TGFB1 FLNA	9.51e-04	19	71	2	DOID:2256 (is_implicated_in)
Disease	monocyte count	ATRN RASGRP4 HIVEP1 ZBTB7C DIDO1 SIRPB1 PLEKHA6 ATP2B4 ADCY9 SNAP29	1.19e-03	1320	71	10	EFO_0005091
Disease	cortical surface area measurement	SLC38A2 STON1 IFTAP ANK3 RGPD1 PAM ACTL6B STOX1 TANGO6 SNAP29	1.37e-03	1345	71	10	EFO_0010736
Disease	lumbar disc degeneration	HIVEP1 STOX1	2.07e-03	28	71	2	EFO_0004994
Disease	Epileptic encephalopathy	FLNA ACTL6B	2.38e-03	30	71	2	C0543888

Protein segments in the cluster

Peptide	Gene	Start	Entry
VHSKDKSHIPSSLDN	BDP1	2016	A6H8Y1
DHTYSKHVKSEPNLH	ACTL6B	101	O94805
STHKESKDHFISPSA	ASCC2	131	Q9H1I8
HESHHAQSEYIKSLK	CCDC77	336	Q9BR77
HVHKYNPTEKAESES	PAM	406	P19021
EHKAIHKTSSQSAPA	CENPVL1	251	A0A0U1RR11
HKDVFLPNSAHSTSK	CASP8AP2	886	Q9UKL3
HESIQKPYNQKSIHS	ATP2B4	1151	P23634
EVSLEKYNHHISSHK	RAG1	366	P15918
KSAHNLPGEYNEHTK	NMBR	241	P28336
TEKPKYLQHSCHSLE	MTUS1	111	Q9ULD2
EEHPLDKSTAKTFHT	ATP12A	541	P54707
PKAKEQYAVVGHSAH	ATRN	436	O75882
DHKIAYDPSLSSHQA	PCDHGB1	791	Q9Y5G3
LTHAHPNLTVYKKED	ENPP5	286	Q9UJA9
IHSPEEQDFLTKHAS	FCER2	201	P06734
KDSHAHLSPDSTKAL	RASGRP4	306	Q8TDF6
NSSHLPAASYRKKDS	F8	1431	P00451
EDKSHHASPKTAFTA	PRDM12	51	Q9H4Q4
DKDAAAHLQTSHKPS	NRBF2	91	Q96F24
KHPGDSIYKDVTSVH	PDP2	191	Q9P2J9
SAKVTHKNEADDYHL	IFTAP	66	Q86VG3
SIKLNHHDYIDSPSL	IFI44	286	Q8TCB0
EHKAIHKTSSQSAPA	CENPVL2	251	P0DPI3
PKKTHIQDNHDGTYT	FLNA	1591	P21333
PKYLKHNHISSRDNA	GAS2L3	471	Q86XJ1
EHKAIHKTSSQSAPA	CENPVL3	251	A0A0U1RRI6
AKTANKDHLVTAYNH	FKBP3	51	Q00688
ASDHNYNAVKPEKTA	DIDO1	506	Q9BTC0
QLSSNSHPKHCKYSI	ADCY9	36	O60503
HKSAVSPDVHKSAAE	ANK3	2296	Q12955
YESDVRTPKSTKHVH	MAP3K20	516	Q9NYL2
SQEAKSPKVELHSHS	IP6K1	146	Q92551
DLYDVDSKSPNLSKH	CPNE8	96	Q86YQ8
EYPHHRAKEQSQAKS	JADE3	376	Q92613
PAFADAHSNLASIHK	OGT	426	O15294
LKEKCNSHHSSYQPL	RGPD1	491	P0DJD0
HGSYDSNQPHRKTKI	NBPF10	486	Q6P3W6
GKEKDNPASHLHFSI	TAF2	421	Q6P1X5
STSKEQEAKYQASHP	SNAP29	151	O95721
HHKTKDEYLINSQTT	IARS2	536	Q9NSE4
ADQYPHLHNAELSKT	SOX8	121	P57073
DQAPEHISKDLYKSA	SNAPC3	236	Q92966
HTSQDEKPLKYGHAL	NKAPL	286	Q5M9Q1
SKSYALEISAHQKEH	SIRPB1	341	O00241
ARYSHVSQHSPSKKA	PDCD11	1351	Q14690
KAFHSPHDKLSSVSV	THEMIS	371	Q8N1K5
PSDNISRKHTFKAEH	PLEKHA6	116	Q9Y2H5
LSVHQKTHTEEKPYQ	ZNF624	431	Q9P2J8
PETLKYHQKTHQETT	ZSCAN5DP	476	P0CG00
EHKTEKPSLSQQAAH	REV3L	781	O60673
KNSSLDHPHCLSYKL	STON1	641	Q9Y6Q2
PTKQAALKSHYADVD	SLC38A2	31	Q96QD8
SHFDKLGETKQTPHS	STOX1	626	Q6ZVD7
THNEIYDKFKQSTHS	TGFB1	116	P01137
KDPHAHKSSVTSCLY	TMTC2	596	Q8N394
SYLKHHEQSHSDKLP	ZNF521	131	Q96K83
ILQQHASHYKSKSPT	ZNF609	1301	O15014
LTQHQKTHSGAKSYE	ZNF331	426	Q9NQX6
DLLAQYDSSKDKHTP	TANGO6	916	Q9C0B7
SSGSFEKKPDLHALH	TET3	1311	O43151
LKTHQSIHAGEKPYE	ZNF404	426	Q494X3
HQSPSKTDHLTEKAY	ZBTB7C	186	A1YPR0
NLTTHQKTHTGEKPY	ZNF41	551	P51814
QLTSHKISHTGEKPY	ZNF90	551	Q03938
SDLHADQAPNSHVKY	VPS13B	3841	Q7Z7G8
SLIQHTKSHTGEKPY	ZNF140	371	P52738
VLSPAHKDTQDFHKN	ZNF217	591	O75362
SKQYHKHAAGPSQER	ZBTB49	221	Q6ZSB9
VLHSASESHKKQNYI	HIVEP1	86	P15822
ELEQKPTHHYKSASD	WDR81	1856	Q562E7
LSNHKRTHSEEKPYT	ZNF195	481	O14628
DCDYTTNKKISLHNH	ZFY	456	P08048
LHLYTEQSHKEEKTP	ZW10	206	O43264
QPGEHQKTHTDSKSY	ZNF473	306	Q8WTR7
PKYGIKHRSTEHNSS	KIAA0319	1011	Q5VV43
HYEEKKASPSHSDSI	PDE4DIP	1631	Q5VU43