Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	retinoic acid-responsive element binding	RXRA NR2F1 RXRG	7.10e-06	7	119	3	GO:0044323
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1F	7.16e-05	14	119	3	GO:0008331
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1F RIMBP2	1.61e-04	46	119	4	GO:0005245
GeneOntologyMolecularFunction	gated channel activity	CACNA1C CACNA1D CACNA1F CCT8L2 CLCNKA CLCNKB SCN7A RIMBP2 CNGB1	1.77e-04	334	119	9	GO:0022836
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1D	3.48e-04	5	119	2	GO:0086007
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1C CACNA1D CACNA1F CCT8L2 CLCNKA CLCNKB SCN7A RIMBP2 SLC26A11 CNGB1	4.26e-04	459	119	10	GO:0005216
GeneOntologyMolecularFunction	nuclear steroid receptor activity	ESR1 RXRA RXRG	4.31e-04	25	119	3	GO:0003707
GeneOntologyMolecularFunction	nuclear receptor activity	ESR1 RXRA NR2F1 RXRG	4.52e-04	60	119	4	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	ESR1 RXRA NR2F1 RXRG	4.81e-04	61	119	4	GO:0098531
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1C CACNA1D CACNA1F CLCNKA CLCNKB RIMBP2	7.82e-04	182	119	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1C CACNA1D CACNA1F CLCNKA CLCNKB RIMBP2	8.28e-04	184	119	6	GO:0022832
GeneOntologyMolecularFunction	calcium channel activity	CACNA1C CACNA1D CACNA1F RIMBP2 CNGB1	1.06e-03	129	119	5	GO:0005262
GeneOntologyMolecularFunction	channel activity	CACNA1C CACNA1D CACNA1F CCT8L2 CLCNKA CLCNKB SCN7A RIMBP2 SLC26A11 CNGB1	1.19e-03	525	119	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1C CACNA1D CACNA1F CCT8L2 CLCNKA CLCNKB SCN7A RIMBP2 SLC26A11 CNGB1	1.21e-03	526	119	10	GO:0022803
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1D RIMBP2	1.23e-03	9	119	2	GO:0099511
GeneOntologyMolecularFunction	L-serine transmembrane transporter activity	SLC38A5 SLC7A10	1.23e-03	9	119	2	GO:0015194
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1D RIMBP2	1.23e-03	9	119	2	GO:0099626
GeneOntologyMolecularFunction	damaged DNA binding	ERCC1 POLD1 SMC6 TP53BP1	1.60e-03	84	119	4	GO:0003684
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCNKA CLCNKB	1.87e-03	11	119	2	GO:0005247
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1C CACNA1D CACNA1F RIMBP2 CNGB1	2.12e-03	151	119	5	GO:0015085
GeneOntologyCellularComponent	photoreceptor cell cilium	RPGRIP1 CACNA1F PTGS1 RP1 USH2A CNGB1	1.59e-04	139	121	6	GO:0097733
GeneOntologyCellularComponent	PR-DUB complex	ASXL3 ASXL2	1.98e-04	4	121	2	GO:0035517
GeneOntologyCellularComponent	9+0 non-motile cilium	RPGRIP1 CACNA1F PTGS1 RP1 USH2A CNGB1	2.68e-04	153	121	6	GO:0097731
GeneOntologyCellularComponent	endopeptidase complex	PIGS CAPN2 CASP2 PSMD2 PSMD6	3.18e-04	102	121	5	GO:1905369
GeneOntologyCellularComponent	chromosome, telomeric region	ERCC1 POLD1 SMC6 TRIOBP PRKDC TP53BP1	5.65e-04	176	121	6	GO:0000781
Domain	CAC1F_C	CACNA1C CACNA1D CACNA1F	2.21e-07	3	114	3	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1D CACNA1F	2.21e-07	3	114	3	PF16885
Domain	VDCC_L_a1su	CACNA1C CACNA1D CACNA1F	8.82e-07	4	114	3	IPR005446
Domain	Ca_chan_IQ	CACNA1C CACNA1D CACNA1F	7.61e-06	7	114	3	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1D CACNA1F	7.61e-06	7	114	3	PF08763
Domain	VDCC_a1su_IQ	CACNA1C CACNA1D CACNA1F	7.61e-06	7	114	3	IPR014873
Domain	GPHH	CACNA1C CACNA1D CACNA1F	7.61e-06	7	114	3	PF16905
Domain	GPHH_dom	CACNA1C CACNA1D CACNA1F	7.61e-06	7	114	3	IPR031649
Domain	VDCCAlpha1	CACNA1C CACNA1D CACNA1F	2.58e-05	10	114	3	IPR002077
Domain	Znf-C4pol	POLD1 REV3L	3.69e-05	2	114	2	IPR025687
Domain	Nuc_recep-AF1	RXRA RXRG	3.69e-05	2	114	2	PF11825
Domain	Nuc_recep-AF1	RXRA RXRG	3.69e-05	2	114	2	IPR021780
Domain	Cl_channel-K	CLCNKA CLCNKB	3.69e-05	2	114	2	IPR002250
Domain	zf-C4pol	POLD1 REV3L	3.69e-05	2	114	2	PF14260
Domain	CarboxyPept_regulatory_dom	CPXM2 CILP2 CPXM1	6.06e-05	13	114	3	IPR014766
Domain	-	CPXM2 CILP2 CPXM1	6.06e-05	13	114	3	2.60.40.1120
Domain	-	POLD1 REV3L	1.10e-04	3	114	2	3.90.1600.10
Domain	HARE-HTH	ASXL3 ASXL2	1.10e-04	3	114	2	PF05066
Domain	ASXH	ASXL3 ASXL2	1.10e-04	3	114	2	PF13919
Domain	DNA_pol_palm_dom	POLD1 REV3L	1.10e-04	3	114	2	IPR023211
Domain	PHD_3	ASXL3 ASXL2	1.10e-04	3	114	2	PF13922
Domain	DNA_POLYMERASE_B	POLD1 REV3L	1.10e-04	3	114	2	PS00116
Domain	ASX-like_PHD	ASXL3 ASXL2	1.10e-04	3	114	2	IPR026905
Domain	ASXH	ASXL3 ASXL2	1.10e-04	3	114	2	IPR028020
Domain	SWIB_domain	SMARCD1 SMARCD3	1.10e-04	3	114	2	IPR019835
Domain	SWIB	SMARCD1 SMARCD3	1.10e-04	3	114	2	SM00151
Domain	ASX/ASX-like	ASXL3 ASXL2	1.10e-04	3	114	2	IPR024811
Domain	HB1/Asxl_HTH	ASXL3 ASXL2	1.10e-04	3	114	2	IPR007759
Domain	DNA-dir_DNA_pol_B_CS	POLD1 REV3L	1.10e-04	3	114	2	IPR017964
Domain	CarboxyPept-like_regulatory	CPXM2 CILP2 CPXM1	1.41e-04	17	114	3	IPR008969
Domain	Znf_hrmn_rcpt	ESR1 RXRA NR2F1 RXRG	1.76e-04	46	114	4	IPR001628
Domain	NUCLEAR_REC_DBD_2	ESR1 RXRA NR2F1 RXRG	1.76e-04	46	114	4	PS51030
Domain	NUCLEAR_REC_DBD_1	ESR1 RXRA NR2F1 RXRG	1.76e-04	46	114	4	PS00031
Domain	ZnF_C4	ESR1 RXRA NR2F1 RXRG	1.76e-04	46	114	4	SM00399
Domain	zf-C4	ESR1 RXRA NR2F1 RXRG	1.76e-04	46	114	4	PF00105
Domain	Nuclear_hrmn_rcpt	ESR1 RXRA NR2F1 RXRG	1.76e-04	46	114	4	IPR001723
Domain	-	ESR1 RXRA NR2F1 RXRG	1.92e-04	47	114	4	1.10.565.10
Domain	Nucl_hrmn_rcpt_lig-bd	ESR1 RXRA NR2F1 RXRG	2.08e-04	48	114	4	IPR000536
Domain	HOLI	ESR1 RXRA NR2F1 RXRG	2.08e-04	48	114	4	SM00430
Domain	Hormone_recep	ESR1 RXRA NR2F1 RXRG	2.08e-04	48	114	4	PF00104
Domain	DNA_pol_B	POLD1 REV3L	2.20e-04	4	114	2	PF00136
Domain	DNA-dir_DNA_pol_B	POLD1 REV3L	2.20e-04	4	114	2	IPR006172
Domain	DNA-dir_DNA_pol_B_exonuc	POLD1 REV3L	2.20e-04	4	114	2	IPR006133
Domain	DNA-dir_DNA_pol_B_multi_dom	POLD1 REV3L	2.20e-04	4	114	2	IPR006134
Domain	DNA_pol_B_exo1	POLD1 REV3L	2.20e-04	4	114	2	PF03104
Domain	POLBc	POLD1 REV3L	2.20e-04	4	114	2	SM00486
Domain	SWIB	SMARCD1 SMARCD3	3.65e-04	5	114	2	PF02201
Domain	-	ESR1 RXRA NR2F1 RXRG	4.05e-04	57	114	4	3.30.50.10
Domain	Channel_four-helix_dom	CACNA1C CACNA1D CACNA1F SCN7A	4.05e-04	57	114	4	IPR027359
Domain	-	CACNA1C CACNA1D CACNA1F SCN7A	4.05e-04	57	114	4	1.20.120.350
Domain	Znf_NHR/GATA	ESR1 RXRA NR2F1 RXRG	4.33e-04	58	114	4	IPR013088
Domain	-	SMARCD1 SMARCD3	5.45e-04	6	114	2	1.10.245.10
Domain	SWIB_MDM2_domain	SMARCD1 SMARCD3	5.45e-04	6	114	2	IPR003121
Domain	Ion_trans_dom	CACNA1C CACNA1D CACNA1F SCN7A CNGB1	6.71e-04	114	114	5	IPR005821
Domain	Ion_trans	CACNA1C CACNA1D CACNA1F SCN7A CNGB1	6.71e-04	114	114	5	PF00520
Domain	DHC_N1	DYNC2H1 DYNC1H1	1.01e-03	8	114	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DYNC1H1	1.01e-03	8	114	2	IPR013594
Domain	Cl-channel_core	CLCNKA CLCNKB	1.29e-03	9	114	2	IPR014743
Domain	-	CLCNKA CLCNKB	1.29e-03	9	114	2	1.10.3080.10
Domain	Voltage_CLC	CLCNKA CLCNKB	1.29e-03	9	114	2	PF00654
Domain	Cl-channel_volt-gated	CLCNKA CLCNKB	1.29e-03	9	114	2	IPR001807
Domain	Leu-rich_rpt	LINGO3 LRRC30 SKP2 LRCH1 TONSL LRRN2 PPP1R42	1.38e-03	271	114	7	IPR001611
Domain	An_peroxidase	TPO PTGS1	1.61e-03	10	114	2	PF03098
Domain	Haem_peroxidase_animal	TPO PTGS1	1.61e-03	10	114	2	IPR019791
Domain	Retinoid-X_rcpt/HNF4	RXRA RXRG	1.61e-03	10	114	2	IPR000003
Domain	Haem_peroxidase	TPO PTGS1	1.61e-03	10	114	2	IPR010255
Domain	PEROXIDASE_3	TPO PTGS1	1.61e-03	10	114	2	PS50292
Domain	-	TPO PTGS1	1.61e-03	10	114	2	1.10.640.10
Domain	LRR_1	LINGO3 LRRC30 SKP2 LRCH1 LRRN2 PPP1R42	2.26e-03	219	114	6	PF00560
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	IPR013602
Domain	DHC_N2	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	IPR011704
Domain	MT	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	PF12777
Domain	AAA_8	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	PF12780
Domain	AAA_5	DYNC2H1 DYNC1H1	3.20e-03	14	114	2	PF07728
Domain	-	LINGO3 LRRC30 SKP2 LRCH1 TONSL LRRN2 PPP1R42	3.56e-03	321	114	7	3.80.10.10
Domain	DHC_fam	DYNC2H1 DYNC1H1	3.68e-03	15	114	2	IPR026983
Domain	Dynein_heavy	DYNC2H1 DYNC1H1	3.68e-03	15	114	2	PF03028
Domain	Dynein_heavy_dom	DYNC2H1 DYNC1H1	3.68e-03	15	114	2	IPR004273
Domain	L_dom-like	LINGO3 LRRC30 SKP2 LRCH1 TONSL LRRN2 PPP1R42	4.01e-03	328	114	7	IPR032675
Domain	CBS	CLCNKA CLCNKB	4.19e-03	16	114	2	SM00116
Domain	Rib_L2_dom2	CUL9 TP53BP1	5.30e-03	18	114	2	IPR014722
Domain	Zn_pept	CPXM2 CPXM1	5.30e-03	18	114	2	SM00631
Domain	-	CUL9 TP53BP1	5.30e-03	18	114	2	2.30.30.30
Domain	CARBOXYPEPT_ZN_2	CPXM2 CPXM1	5.90e-03	19	114	2	PS00133
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1F	4.18e-06	6	85	3	M47762
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1C CACNA1D CACNA1F	7.34e-05	14	85	3	M47692
Pathway	WP_NUCLEAR_RECEPTORS	ESR1 RXRA NR2F1 RXRG	7.77e-05	38	85	4	M39657
Pathway	WP_NUCLEAR_RECEPTORS	ESR1 RXRA NR2F1 RXRG	7.77e-05	38	85	4	MM15865
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	ESR1 RXRA NR2F1 RXRG	1.96e-04	48	85	4	MM14987
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	ESR1 RXRA NR2F1 RXRG	2.88e-04	53	85	4	M8276
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1F	3.43e-04	23	85	3	M47666
Pathway	KEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION	RXRA RXRG	3.55e-04	5	85	2	M49023
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	CACNA1C CACNA1D CACNA1F MAP3K4 MAP3K2	3.56e-04	101	85	5	M1979
Pubmed	Enhancer activation requires trans-recruitment of a mega transcription factor complex.	ESR1 RXRA RXRG PRKDC	3.08e-08	10	123	4	25303530
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MED6 ERCC1 POLD1 SMC6 PSMD2 PSMD6 UBR5 TONSL SMARCD1 SMARCD3 MGA TP53BP1	8.05e-08	453	123	12	29656893
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1D CACNA1F	1.72e-07	4	123	3	20937870
Pubmed	Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase.	CAND2 PSMD2 PSMD6	8.57e-07	6	123	3	12692129
Pubmed	Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.	RXRA NR2F1 RXRG	8.57e-07	6	123	3	7947324
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	DOCK4 CAND2 PSMD2 DAXX NR2F1 PRKDC MTREX	1.47e-06	156	123	7	22952844
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1D CACNA1F	1.50e-06	7	123	3	12900400
Pubmed	Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair.	ROBO4 ESR1 RXRA	1.50e-06	7	123	3	14761960
Pubmed	The structure of the nuclear hormone receptors.	ESR1 RXRA RXRG	1.50e-06	7	123	3	10406480
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	COPA UGGT1 PSMD6 UBR5 PRKDC IAH1 MTREX USH2A	1.79e-06	231	123	8	36597993
Pubmed	A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.	ESR1 RXRA RXRG	2.39e-06	8	123	3	8616895
Pubmed	A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells.	RXRA NR2F1 RXRG	3.57e-06	9	123	3	7823919
Pubmed	The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.	ESR1 RXRA SMARCD3	5.09e-06	10	123	3	17363140
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	NAA15 COPA POLD1 PSMD2 UBR5 PRKDC MTREX DYNC1H1	5.98e-06	272	123	8	25315684
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1C CACNA1D CACNA1F	6.98e-06	11	123	3	18809727
Pubmed	Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.	ESR1 RXRA NR2F1	9.28e-06	12	123	3	15140878
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1C CACNA1D CACNA1F CLCNKA CLCNKB SCN7A	1.06e-05	139	123	6	16985003
Pubmed	The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.	CLCNKA CLCNKB	1.24e-05	2	123	2	27335120
Pubmed	Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.	CLCNKA CLCNKB	1.24e-05	2	123	2	8812470
Pubmed	Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.	CLCNKA CLCNKB	1.24e-05	2	123	2	25919862
Pubmed	Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.	CACNA1C CACNA1D	1.24e-05	2	123	2	21054386
Pubmed	Estrogenic effect on the expression of estrogen receptor, COUP-TF, and lactoferrin mRNA in developing mouse tissues.	ESR1 NR2F1	1.24e-05	2	123	2	8873065
Pubmed	Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.	CACNA1D CACNA1F	1.24e-05	2	123	2	25966695
Pubmed	Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.	CLCNKA CLCNKB	1.24e-05	2	123	2	38069401
Pubmed	An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.	CACNA1C CACNA1D	1.24e-05	2	123	2	24086669
Pubmed	Genetic analysis of the cytoplasmic dynein subunit families.	DYNC2H1 DYNC1H1	1.24e-05	2	123	2	16440056
Pubmed	Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.	CACNA1C CACNA1D	1.24e-05	2	123	2	26049024
Pubmed	Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.	CACNA1C CACNA1D	1.24e-05	2	123	2	19225208
Pubmed	Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.	CACNA1C CACNA1D	1.24e-05	2	123	2	16706838
Pubmed	A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.	CLCNKA CLCNKB	1.24e-05	2	123	2	20805576
Pubmed	Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.	CACNA1C CACNA1D	1.24e-05	2	123	2	23761887
Pubmed	Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle.	SMARCD1 SMARCD3	1.24e-05	2	123	2	29092888
Pubmed	Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.	CACNA1C CACNA1D	1.24e-05	2	123	2	14981074
Pubmed	CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.	CACNA1C CACNA1D	1.24e-05	2	123	2	25292336
Pubmed	Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.	CACNA1C CACNA1D	1.24e-05	2	123	2	17526649
Pubmed	Ligand-activated signal transduction in the 2-cell embryo.	CACNA1C CACNA1D	1.24e-05	2	123	2	12606379
Pubmed	Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.	CACNA1C CACNA1D	1.24e-05	2	123	2	24941892
Pubmed	Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.	RXRA RXRG	1.24e-05	2	123	2	34633445
Pubmed	ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation.	ESR1 ASXL2	1.24e-05	2	123	2	26640146
Pubmed	Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.	CACNA1C CACNA1D	1.24e-05	2	123	2	22826131
Pubmed	C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.	CACNA1D CACNA1F	1.24e-05	2	123	2	16921373
Pubmed	Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.	CACNA1C CACNA1D	1.24e-05	2	123	2	24470632
Pubmed	Salt wasting and deafness resulting from mutations in two chloride channels.	CLCNKA CLCNKB	1.24e-05	2	123	2	15044642
Pubmed	Two highly homologous members of the ClC chloride channel family in both rat and human kidney.	CLCNKA CLCNKB	1.24e-05	2	123	2	8041726
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.	CACNA1C CACNA1D	1.24e-05	2	123	2	24760982
Pubmed	A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.	CLCNKA CLCNKB	1.24e-05	2	123	2	18648499
Pubmed	Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.	CLCNKA CLCNKB	1.24e-05	2	123	2	8544406
Pubmed	Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.	CACNA1C CACNA1D	1.24e-05	2	123	2	20014384
Pubmed	The retinoid X receptors and their ligands.	RXRA RXRG	1.24e-05	2	123	2	22020178
Pubmed	Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse.	RXRA RXRG	1.24e-05	2	123	2	10880050
Pubmed	Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.	CACNA1C CACNA1D	1.24e-05	2	123	2	30001160
Pubmed	Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.	CLCNKA CLCNKB	1.24e-05	2	123	2	24863058
Pubmed	Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.	CACNA1C CACNA1D	1.24e-05	2	123	2	21352396
Pubmed	Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.	CLCNKA CLCNKB	1.24e-05	2	123	2	9916798
Pubmed	Kidney kinetics and chloride ion pumps.	CLCNKA CLCNKB	1.24e-05	2	123	2	9916791
Pubmed	Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.	CACNA1C CACNA1D	1.24e-05	2	123	2	17409250
Pubmed	Neuronal L-type calcium channels open quickly and are inhibited slowly.	CACNA1C CACNA1D	1.24e-05	2	123	2	16267232
Pubmed	Selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in severe combined immune-deficient mice.	FMO3 PRKDC	1.24e-05	2	123	2	22745333
Pubmed	The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.	CACNA1C CACNA1D	1.24e-05	2	123	2	24996399
Pubmed	Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.	RXRA NR2F1	1.24e-05	2	123	2	1311101
Pubmed	Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.	ESR1 PRKDC	1.24e-05	2	123	2	20219974
Pubmed	Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.	CACNA1C CACNA1D	1.24e-05	2	123	2	24849370
Pubmed	Inhibition of microtubules and dynein rescues human immunodeficiency virus type 1 from owl monkey TRIMCyp-mediated restriction in a cellular context-specific fashion.	DYNC2H1 DYNC1H1	1.24e-05	2	123	2	25502651
Pubmed	Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.	CACNA1C CACNA1D	1.24e-05	2	123	2	17015854
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.	CACNA1C CACNA1D	1.24e-05	2	123	2	24848473
Pubmed	Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.	ESR1 PRKDC	1.24e-05	2	123	2	20111054
Pubmed	Retinoid X receptor γ up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma.	RXRA RXRG	1.24e-05	2	123	2	21355951
Pubmed	Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.	CLCNKA CLCNKB	1.24e-05	2	123	2	11014860
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	COPA PSMD2 UBR5 PRKDC MTREX MGA DYNC1H1	1.45e-05	221	123	7	29991511
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	RPGRIP1 CACNA1F RP1 USH2A CNGB1	1.49e-05	87	123	5	20801516
Pubmed	MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.	MED6 ESR1 RXRA	1.53e-05	14	123	3	17641689
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1D CACNA1F	1.90e-05	15	123	3	20188150
Pubmed	Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.	ESR1 RXRA SMARCD3	1.90e-05	15	123	3	14701856
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1D CACNA1F	1.90e-05	15	123	3	24453333
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	RASGRP4 COPA DYNC2H1 INTS1 PSMD2 SMARCD1 PRKDC DYNC1H1	2.03e-05	322	123	8	26514267
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	ERCC1 COPA UGGT1 ARHGAP9 UBR5 PRKDC TP53BP1	2.15e-05	235	123	7	30258100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NAA15 COPA UGGT1 INTS1 CUL9 PSMD2 UBR5 PRKDC MTREX DYNC1H1 TP53BP1	2.17e-05	653	123	11	22586326
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	RPGRIP1 DYNC2H1 UGGT1 SOX30 CAPN2 GPKOW UBR5 SMARCD1 USH2A DYNC1H1 TP53BP1	2.74e-05	670	123	11	22990118
Pubmed	Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.	CLCNKA CLCNKB	3.71e-05	3	123	2	26013830
Pubmed	Barttin increases surface expression and changes current properties of ClC-K channels.	CLCNKA CLCNKB	3.71e-05	3	123	2	12111250
Pubmed	Regulation of proteolytic cleavage of retinoid X receptor-α by GSK-3β.	CAPN2 RXRA	3.71e-05	3	123	2	23389291
Pubmed	Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes.	CAPN2 ITGAL	3.71e-05	3	123	2	21152086
Pubmed	Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.	CLCNKA CLCNKB	3.71e-05	3	123	2	17510212
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1C CACNA1D	3.71e-05	3	123	2	17767505
Pubmed	The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.	ESR1 NR2F1	3.71e-05	3	123	2	10620335
Pubmed	Cytoplasmic dynein promotes HIV-1 uncoating.	DYNC2H1 DYNC1H1	3.71e-05	3	123	2	25375884
Pubmed	Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.	RXRA RXRG	3.71e-05	3	123	2	11053444
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1C CACNA1D	3.71e-05	3	123	2	2173707
Pubmed	Retinoid X receptors: X-ploring their (patho)physiological functions.	RXRA RXRG	3.71e-05	3	123	2	15608692
Pubmed	Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility.	FER1L6 FER1L4	3.71e-05	3	123	2	36696506
Pubmed	Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.	DYNC2H1 DYNC1H1	3.71e-05	3	123	2	8666668
Pubmed	Retinoid receptors trigger neuritogenesis in retinal degenerations.	RXRA RXRG	3.71e-05	3	123	2	21940995
Pubmed	G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.	CACNA1C CACNA1D	3.71e-05	3	123	2	26831068
Pubmed	Barttin modulates trafficking and function of ClC-K channels.	CLCNKA CLCNKB	3.71e-05	3	123	2	16849430
Pubmed	The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers.	RXRA RXRG	3.71e-05	3	123	2	12824162
Pubmed	Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.	CLCNKA CLCNKB	3.71e-05	3	123	2	18094726
Pubmed	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	CACNA1C CACNA1D	3.71e-05	3	123	2	23338940
Pubmed	Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice.	SMARCD1 SMARCD3	3.71e-05	3	123	2	27125315
Pubmed	Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.	CLCNKA CLCNKB	3.71e-05	3	123	2	10982849
Pubmed	RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.	RXRA RXRG	3.71e-05	3	123	2	8799145
Interaction	NR1H4 interactions	ESR1 RXRA RXRG SMARCD1 SMARCD3 PRKDC	2.84e-08	32	118	6	int:NR1H4
Interaction	THRA interactions	MED6 MED16 ESR1 RXRA NR2F1 RXRG PRKDC	4.05e-06	111	118	7	int:THRA
Interaction	AR interactions	MED6 MYO5B MED16 POLD1 ESR1 PSMD2 DAXX SKP2 PSMD6 ZBTB32 TAF9B UBR5 TONSL SMARCD1 PRKDC MTREX MGA DYNC1H1	1.83e-05	992	118	18	int:AR
Cytoband	Xp11.23	CACNA1F SLC38A5 GPKOW CHST7	1.33e-04	95	124	4	Xp11.23
Cytoband	19q13.1	RASGRP4 ZBTB32 SLC7A10	4.55e-04	55	124	3	19q13.1
GeneFamily	Nuclear hormone receptors	ESR1 RXRA NR2F1 RXRG	8.20e-05	49	85	4	71
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1D CACNA1F	2.41e-04	26	85	3	253
GeneFamily	Ferlin family	FER1L6 FER1L4	3.24e-04	6	85	2	828
GeneFamily	Chloride voltage-gated channels	CLCNKA CLCNKB	9.59e-04	10	85	2	302
GeneFamily	Dyneins, cytoplasmic	DYNC2H1 DYNC1H1	1.65e-03	13	85	2	538
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C CACNA1D COL6A5 NR2F1 ASXL3 SCN7A LRRN2	9.57e-07	187	124	7	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	CACNA1D FMO3 COL6A5 NR2F1 SCN7A MEDAG PPP1R42	1.10e-06	191	124	7	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	CACNA1D FMO3 COL6A5 NR2F1 SCN7A MEDAG PPP1R42	1.10e-06	191	124	7	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	DOCK4 CACNA1C CACNA1D FMO3 SLC38A5 COL6A5 SCN7A	1.18e-06	193	124	7	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 CACNA1D CPXM2 DYNC2H1 SLC38A5 COL6A5 SLC26A11	1.40e-06	198	124	7	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK4 CACNA1D DYNC2H1 COL6A5 REV3L NR2F1 CPXM1	1.50e-06	200	124	7	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C CACNA1D FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	1.50e-06	200	124	7	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CACNA1C CACNA1D FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	1.50e-06	200	124	7	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CACNA1C CACNA1D FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	1.50e-06	200	124	7	a510deaada669e690329183e18df02870bd204b3
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CACNA1C CACNA1D FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	1.50e-06	200	124	7	dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell	droplet-Heart-HEART-1m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK4 SLC38A5 TRIM10 DIPK2B ABHD1	2.17e-06	75	124	5	f1ad409d1b2c5f23bf2b22137e612d627c041b97
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 DYNC2H1 SCN7A B4GALNT3 USH2A	2.69e-06	140	124	6	5e81fa3a19d23f0e9cae3878431ca1f78dff7238
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	CACNA1C CYP21A2 NR2F1 ZSCAN32 SCN7A BRINP2	5.41e-06	158	124	6	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DOCK4 CLCNKA CLCNKB LRRN2 RIMBP2 PNMA3	7.18e-06	166	124	6	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	droplet-Heart-HEART-1m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK4 PIGS TRIM10 DIPK2B ABHD1	9.40e-06	101	124	5	6c4524be89cf3eb06769c2963dcded3da1e71ca0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 DYNC2H1 LRCH1 SCN7A B4GALNT3	1.10e-05	179	124	6	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPXM2 DYNC2H1 CLCNKA CLCNKB SCN7A B4GALNT3	1.25e-05	183	124	6	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPXM2 DYNC2H1 LRCH1 CLCNKA CLCNKB B4GALNT3	1.25e-05	183	124	6	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCNKB SCN7A MEDAG CPXM1 LRRN2 B4GALNT3	1.37e-05	186	124	6	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCDHB4 PSMD2 REV3L SAPCD2 CPXM1 PRKDC	1.37e-05	186	124	6	10565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCNKB SCN7A MEDAG CPXM1 LRRN2 B4GALNT3	1.37e-05	186	124	6	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C FMO3 ESR1 REV3L NR2F1 TAC1	1.41e-05	187	124	6	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 LRCH1 CLCNKA CLCNKB B4GALNT3	1.46e-05	188	124	6	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 LRCH1 CLCNKA CLCNKB B4GALNT3	1.46e-05	188	124	6	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1D CPXM2 DYNC2H1 CLCNKA CLCNKB RIMBP2	1.46e-05	188	124	6	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 CLCNKA CLCNKB RIMBP2 RP1	1.50e-05	189	124	6	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 DYNC2H1 LRCH1 SCN7A B4GALNT3	1.50e-05	189	124	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 DYNC2H1 LRCH1 SCN7A B4GALNT3	1.50e-05	189	124	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-A\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	EVPL COL6A5 ZBTB32 SMARCD1 B4GALNT3	1.55e-05	112	124	5	d21cfcb04a27cc9fb74e0c2afa8a8cdfb886ae21
ToppCell	droplet-Fat-Gat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A5 NR2F1 SCN7A MEDAG CPXM1 LRRN2	1.59e-05	191	124	6	6cab0334f76c973880bd8d1638856f2f6e4a249a
ToppCell	droplet-Fat-Gat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A5 NR2F1 SCN7A MEDAG CPXM1 LRRN2	1.59e-05	191	124	6	850c6fff6dc795431ef534fdaa41e4ad50f7367a
ToppCell	droplet-Fat-Gat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A5 NR2F1 SCN7A MEDAG CPXM1 LRRN2	1.59e-05	191	124	6	8b2b00202d3c98bccbae1b4a23713892fad0ff23
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	DOCK4 CACNA1D FMO3 SLC38A5 NR2F1 SCN7A	1.64e-05	192	124	6	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Adcy1_(Reticular_formation)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX30 FER1L6 CILP2 B4GALNT3	1.68e-05	55	124	4	a911a29c2db5bf32a209a9c01afc96c9f8b401f6
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Adcy1_(Reticular_formation)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX30 FER1L6 CILP2 B4GALNT3	1.68e-05	55	124	4	cff015b3803f5c06afc8b22be057322e0dcbd4f2
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK4 TPO ROBO4 CPXM2 DIPK2B RP1	1.69e-05	193	124	6	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	Control-Stromal-Myofibroblast\|Control / Disease state, Lineage and Cell class	CACNA1C CACNA1D FMO3 SLC38A5 NR2F1 SCN7A	1.79e-05	195	124	6	ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D DYNC2H1 UGGT1 REV3L MGA DYNC1H1	1.79e-05	195	124	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C FMO3 ESR1 REV3L NR2F1 OR1J2	1.79e-05	195	124	6	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D DYNC2H1 UGGT1 REV3L MGA DYNC1H1	1.79e-05	195	124	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DOCK4 CACNA1D FMO3 SLC38A5 NR2F1 SCN7A	1.85e-05	196	124	6	6730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DOCK4 CACNA1D FMO3 SLC38A5 NR2F1 SCN7A	1.85e-05	196	124	6	21dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|normal_Lung / Location, Cell class and cell subclass	CACNA1D FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	1.90e-05	197	124	6	6c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell	distal-Endothelial-Lymphatic-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CPXM2 CARD10 NR2F1 DIPK2B AGXT MEDAG	1.90e-05	197	124	6	8f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C CACNA1D SLC38A5 COL6A5 NR2F1 SCN7A	1.95e-05	198	124	6	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C CACNA1D SLC38A5 COL6A5 NR2F1 SCN7A	2.01e-05	199	124	6	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	343B-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DOCK4 FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	2.01e-05	199	124	6	212e89d097753790061310373a1fafba773488b6
ToppCell	343B-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DOCK4 FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	2.01e-05	199	124	6	14b676aa289c0578a37be32cec3ea285c79d97cc
ToppCell	cellseq-Mesenchymal-Fibroblastic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1D SLC38A5 COL6A5 NR2F1 SCN7A MEDAG	2.07e-05	200	124	6	8978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_alveolar\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1D FMO3 STON1 SLC38A5 NR2F1 SCN7A	2.07e-05	200	124	6	750ff51c9de08aecec230f4a402e0bf5a789f24c
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_alveolar\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FMO3 STON1 SLC38A5 COL6A5 NR2F1 SCN7A	2.07e-05	200	124	6	fda92cb28de99a9c4fe83b7db8145a4beafb0826
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FMO3 SLC38A5 COL6A5 NR2F1 SCN7A	2.07e-05	200	124	6	cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCell	\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF19 ENPP3 EVPL PTGS1 BRINP2	2.26e-05	121	124	5	da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPO LINGO3 PTGS1 FER1L6 USH2A	2.64e-05	125	124	5	b1a12400f7070bdf09e87974c548a8b82e92b65e
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_smooth_muscle-like\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TPO ABAT SOX30 LENG9 RIMBP2	3.43e-05	132	124	5	9633653dba1edee47d915212fb6e68426da49de5
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	CYP21A2 CCDC168 CCT8L2 UBR5 ASXL3	3.82e-05	135	124	5	3351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CLCNKA CLCNKB LRRN2 B4GALNT3	6.30e-05	150	124	5	87968ce885a4959616f0321f58517fe8029ba1b1
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	6.71e-05	152	124	5	32634195048858ae84605c61e43c542d90f7cab5
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	6.71e-05	152	124	5	0eb185b2404f015efff1bd140e0c502d714720fb
ToppCell	Control-Epithelial-Ionocyte\|Epithelial / Disease state, Lineage and Cell class	RASGRP4 CLCNKA CLCNKB ASXL3 LRRN2	7.36e-05	155	124	5	4b9369b203a4d7071c56d3d8e6b450e9a0121c41
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 LRCH1 CLCNKB SCN7A	7.59e-05	156	124	5	4d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCell	facs-Lung-Endomucin_-18m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP4 ARHGAP9 ITGAL ARG2 TAC1	7.82e-05	157	124	5	2b60de520edf167f5ca790b478557a778435b3d9
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C SOX30 COL6A5 NR2F1 SCN7A	7.82e-05	157	124	5	f147e24f2ece82e1c54750868954d09b3c461804
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C SOX30 COL6A5 NR2F1 SCN7A	8.06e-05	158	124	5	e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	8.30e-05	159	124	5	ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	8.30e-05	159	124	5	7b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGRP4 ESR1 SLC38A5 DIPK2B	8.53e-05	83	124	4	3aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGRP4 ESR1 SLC38A5 DIPK2B	8.53e-05	83	124	4	70804dd63221dd5ed26068ec1b50f11875abbc50
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGRP4 ESR1 SLC38A5 DIPK2B	8.53e-05	83	124	4	c1818411438f53aec76afead5c8caab701b95d39
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGRP4 ESR1 SLC38A5 DIPK2B	8.53e-05	83	124	4	1e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PATL2 LINGO3 DOK2 ITGAL PTGS1	8.55e-05	160	124	5	955acb023ce4ccfac5073c9d693db87db3856187
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ROBO4 SLC38A5 DIPK2B CNGB1	8.94e-05	84	124	4	f7ce09c6fb2795b7aecabce00cb9830b3c1a7d0e
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ROBO4 SLC38A5 DIPK2B CNGB1	8.94e-05	84	124	4	5d5e519a6652029b9f5275c8e648bbb123fd07b9
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ROBO4 SLC38A5 DIPK2B CNGB1	8.94e-05	84	124	4	2b477de422a9f6a8474cba05094577b88236a4f0
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	PCDHB4 CCDC168 NR2F1 SCN7A MEDAG	1.02e-04	166	124	5	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PCDHB4 CCDC168 NR2F1 SCN7A MEDAG	1.02e-04	166	124	5	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 TRIM10 DIPK2B CNGB1	1.03e-04	87	124	4	cc89f4176b70d4eb5b5bf0ff2319b5f1f9e292c0
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 TRIM10 DIPK2B CNGB1	1.03e-04	87	124	4	4274e04fa4aca85c2cefd8c5e03d0fa4a4f15536
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 TRIM10 DIPK2B CNGB1	1.03e-04	87	124	4	54cbdf80aae3595eaace20c7cbac763282558213
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 TRIM10 DIPK2B CNGB1	1.03e-04	87	124	4	8b1a0bd5d6af32afaca19e9c69f86530bbaa309d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO5B CYP21A2 SLC38A5 ITGAL PNMA3	1.05e-04	167	124	5	abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cfh_(Cfh)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 DIPK2B RP1 CNGB1	1.07e-04	88	124	4	5582666aed9c1f465264f18898783872b662400d
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cfh_(Cfh)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 DIPK2B RP1 CNGB1	1.07e-04	88	124	4	5f774a85415d3cf163046f1154a82f749bf628fe
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cfh_(Cfh)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC38A5 DIPK2B RP1 CNGB1	1.07e-04	88	124	4	f59eeaba4a3c5ef03f741ed6a31fe88f57651374
ToppCell	10x5'-lymph-node_spleen-Mast-Mast_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	1.08e-04	168	124	5	650ad3ea52577887885d82457dbc04202ce3eb34
ToppCell	10x5'-lymph-node_spleen-Mast\|lymph-node_spleen / Manually curated celltypes from each tissue	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	1.08e-04	168	124	5	e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCell	-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	CACNA1C SLC38A5 COL6A5 NR2F1 SCN7A	1.11e-04	169	124	5	8ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CACNA1D RASGRP4 SAPCD2 PTGS1 CPXM1	1.17e-04	171	124	5	4ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell	Endothelial-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 NR2F1 DIPK2B MEDAG LRRN2	1.17e-04	171	124	5	07ff7059071da83da1d8f266a586573920d75b58
ToppCell	droplet-Marrow-BM-1m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP4 TRIOBP LRRC30 FER1L4 PPP1R42	1.17e-04	171	124	5	8a0c08f0aa3a80cd6346c81deb242e430ebd897b
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ABAT POLD1 ESR1 PTGS1 RXRA	1.20e-04	172	124	5	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CPXM2 LRCH1 CLCNKB B4GALNT3	1.23e-04	173	124	5	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	10x5'-GI_small-bowel-Mast\|GI_small-bowel / Manually curated celltypes from each tissue	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	1.27e-04	174	124	5	e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCell	10x5'-GI_small-bowel-Mast-Mast_cells\|GI_small-bowel / Manually curated celltypes from each tissue	RASGRP4 ENPP3 EVPL PTGS1 SCN7A	1.27e-04	174	124	5	05525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPXM2 CCT8L2 CLCNKA CLCNKB SCN7A	1.30e-04	175	124	5	787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCell	Endothelial-B-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 CPXM2 NR2F1 DIPK2B MEDAG	1.34e-04	176	124	5	b288116a4588a1f9db9d49af92cea118937c9201
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B CLCNKB SCN7A TAC1 CCT8L1P	1.37e-04	177	124	5	5e0fca9bd5e5ffe6d39f5bcd81f36512f3b0cb1b
ToppCell	metastatic_Lymph_Node-Endothelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ROBO4 CPXM2 DIPK2B ASXL3 MEDAG	1.37e-04	177	124	5	71bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPXM2 DYNC2H1 CAPN2 CLCNKB SCN7A	1.37e-04	177	124	5	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO5B CLCNKA PLCH2 SCN7A TAC1	1.45e-04	179	124	5	d1365d48d1b017a7917f4f63a82ac4720c3d87df
Drug	E-guggulsterone	TPO ESR1 PTGS1 RXRA NR2F1 RXRG TONSL	1.70e-06	108	120	7	CID006439929
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1D CACNA1F	2.49e-07	4	118	3	DOID:0060173 (implicated_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1D CACNA1F CAPN2	1.30e-05	36	118	4	DOID:11723 (implicated_via_orthology)
Disease	Bartter disease type 4B	CLCNKA CLCNKB	1.59e-05	2	118	2	cv:C4310805
Disease	Bartter disease type 3 (implicated_via_orthology)	CLCNKA CLCNKB	1.59e-05	2	118	2	DOID:0110144 (implicated_via_orthology)
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	1.59e-05	2	118	2	613090
Disease	BARTTER SYNDROME, TYPE 4B	CLCNKA CLCNKB	1.59e-05	2	118	2	C2751312
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	1.59e-05	2	118	2	C4310805
Disease	Bartter disease type 4b (is_implicated_in)	CLCNKA CLCNKB	1.59e-05	2	118	2	DOID:0110146 (is_implicated_in)
Disease	Bartter disease (implicated_via_orthology)	CLCNKA CLCNKB	1.59e-05	2	118	2	DOID:445 (implicated_via_orthology)
Disease	Gastroesophageal reflux disease	ABAT TAC1	9.46e-05	4	118	2	C0017168
Disease	GDNF family receptor alpha-2 measurement	DOK2 SAPCD2	9.46e-05	4	118	2	EFO_0008138
Disease	retinitis pigmentosa (implicated_via_orthology)	RPGRIP1 USH2A CNGB1	1.70e-04	27	118	3	DOID:10584 (implicated_via_orthology)
Disease	Bartter syndrome	CLCNKA CLCNKB	2.35e-04	6	118	2	cv:C0004775
Disease	pyridoxate measurement	CACNA1D RIMBP2 CFAP99	2.58e-04	31	118	3	EFO_0010527
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	FER1L6 FER1L4	3.29e-04	7	118	2	DOID:11724 (implicated_via_orthology)
Disease	Coffin-Siris syndrome (implicated_via_orthology)	SMARCD1 SMARCD3	5.60e-04	9	118	2	DOID:1925 (implicated_via_orthology)
Disease	2R,3R-dihydroxybutyrate measurement	CYP21A2 AGXT	5.60e-04	9	118	2	EFO_0800314
Disease	retinitis pigmentosa (is_implicated_in)	RPGRIP1 USH2A CNGB1	5.95e-04	41	118	3	DOID:10584 (is_implicated_in)
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	CLCNKA CLCNKB	6.99e-04	10	118	2	DOID:12387 (implicated_via_orthology)
Disease	Retinitis Pigmentosa	RPGRIP1 RP1 USH2A CNGB1	8.21e-04	104	118	4	C0035334
Disease	ovary epithelial cancer (is_implicated_in)	ERCC1 DAXX	8.52e-04	11	118	2	DOID:2152 (is_implicated_in)
Disease	ficolin-3 measurement	RP1 B4GALNT3	1.02e-03	12	118	2	EFO_0020392
Disease	Bronchial Hyperreactivity	PTGS1 TAC1	1.02e-03	12	118	2	C0085129
Disease	retinal vasculature measurement	TPO CACNA1C CYP21A2 ARHGAP9 LRCH1 RXRA SCN7A RIMBP2	1.14e-03	517	118	8	EFO_0010554
Disease	Endometrial Neoplasms	POLD1 ESR1 MAP3K4	1.64e-03	58	118	3	C0014170
Disease	Disorder of eye	RPGRIP1 CACNA1F RP1 USH2A CNGB1	1.66e-03	212	118	5	C0015397
Disease	T-Cell Lymphoma	ASXL3 MGA	1.83e-03	16	118	2	C0079772
Disease	immunoglobulin lambda-like polypeptide 1 measurement	AGXT SLC7A10	1.83e-03	16	118	2	EFO_0801688
Disease	Muscle hypotonia	ABAT INTS1	2.07e-03	17	118	2	C0026827
Disease	Deaf Mutism	CACNA1D POLD1	2.87e-03	20	118	2	C4082305
Disease	Deafness, Acquired	CACNA1D POLD1	2.87e-03	20	118	2	C0751068
Disease	Hearing Loss, Extreme	CACNA1D POLD1	2.87e-03	20	118	2	C0086395
Disease	Complete Hearing Loss	CACNA1D POLD1	2.87e-03	20	118	2	C0581883
Disease	Bilateral Deafness	CACNA1D POLD1	2.87e-03	20	118	2	C3665473
Disease	Prelingual Deafness	CACNA1D POLD1	2.87e-03	20	118	2	C0011052
Disease	Manic Disorder	CACNA1C CACNA1D TAC1	2.92e-03	71	118	3	C0024713
Disease	Endometrial Carcinoma	POLD1 ESR1 MAP3K4	3.04e-03	72	118	3	C0476089
Disease	Retinitis pigmentosa	RP1 USH2A CNGB1	3.29e-03	74	118	3	cv:C0035334
Disease	basophil count	RASGRP4 TRIOBP PSMD2 COL6A5 CILP2 PRKDC SLC7A10	3.34e-03	483	118	7	EFO_0005090
Disease	Manic	CACNA1C CACNA1D TAC1	3.81e-03	78	118	3	C0338831
Disease	Depression, Bipolar	CACNA1C CACNA1D TAC1	3.95e-03	79	118	3	C0005587

Protein segments in the cluster

Peptide	Gene	Start	Entry
KERVIRRLLLQAPPG	CAPZA3	11	Q96KX2
ALDQLRLVRPKPVGA	CARD10	796	Q9BWT7
FLLRELQDKVPQLPG	ARG2	166	P78540
RKLLAQPREGLLAPF	B4GALNT3	476	Q6L9W6
ARKNLPRAIFISIPL	SLC7A10	261	Q9NS82
GLRNVNLILLNKPPE	C14orf28	281	Q4W4Y0
QRLRELLAAGAKVPP	CPXM1	706	Q96SM3
VCQKLLPRLLQGRFP	DIPK2B	361	Q9H7Y0
EVNRRIERLINKPGP	DAXX	266	Q9UER7
PQPFLNRGDRIQVRK	ASXL2	601	Q76L83
QVPRPLQLFSAKELR	ASXL2	1031	Q76L83
QPRLGAKLEINRLPL	ASXL3	1766	Q9C0F0
QPVSLPARRLKLRGQ	CPXM2	736	Q8N436
PNQPSRFGKLLLRLP	NR2F1	361	P10589
QRLLLENPRFPGILA	ARHGEF19	481	Q8IW93
GSKQQLRLQFPPRIR	CFAP99	266	D6REC4
DVVALLRRIQPPLGF	CACNA1F	1481	O60840
EFLLLGLPIRPEQQA	OR1J2	11	Q8NGS2
GKNFRGILAVPPQLL	DOK2	311	O60496
RNNEIILFKGVFPPL	FMO3	346	P31513
LERLQRSGELPPQKL	LIN7B	21	Q9HAP6
KRAGPRLLLIPVQQG	MGA	1756	Q8IWI9
PQKRREELVLRVQGP	INTS1	1716	Q8N201
RVPRRALEQVPGLKF	LRRN2	251	O75325
IAQPGRPRQILAFEL	KIAA1109	371	Q2LD37
FGRKLRFLLQQLPPV	FAM13B	131	Q9NYF5
LGILPPENFVEKLRQ	ABAT	131	P80404
RRNVFFPKGRELQIP	FRMD8P1	126	Q9BZ68
QISRGIPQNRPIKLL	FER1L4	1236	A9Z1Z3
RFFPNPGLRRLKQAI	CYP21A2	216	P08686
IIVSPRQRGNPVLKF	ERCC1	101	P07992
LNRPQLKIPLERPLG	ESR1	26	P03372
QRIQRVPQFPGKLLL	FHIP2B	671	Q86V87
VPQFPGKLLLVRKQL	FHIP2B	676	Q86V87
LQQRPGQPPRLLIYK	IGKV2D-24	61	A0A075B6R9
GLNAPPRLSFRKLVL	LENG9	391	Q96B70
DPLIRGLLARPAKLQ	TPO	536	P07202
DPKRTGRIPIQQALL	EVPL	1946	Q92817
RSIGRPELKNLDPFL	PIR	26	O00625
FLLPKISLRGPQADR	FAM47B	76	Q8NA70
RPGPLQRAQVLDKFI	RASGRP4	261	Q8TDF6
RGEKRILQFPRPVKL	MAP3K2	51	Q9Y2U5
FPIRPIRGQQQLKIL	RSKR	96	Q96LW2
GLKPRSVFLRPQRNL	LRCH1	546	Q9Y2L9
VLRLRGNQLKLIPPG	LINGO3	106	P0C6S8
PKELVIPLIQNGHRR	GPKOW	66	Q92917
EFLLLGLPIRPEQQA	OR1J1	11	Q8NGS3
LLRRKFIPDPQGTNL	PTGS1	181	P23219
LPRLIRKGNSLDIPV	IAH1	66	Q2TAA2
PLAQLLRLQPGAFQL	MEDAG	36	Q5VYS4
LVPRRLPLNFLSGEK	NAA15	291	Q9BXJ9
DGLVSRLQPKQPLRL	MED16	736	Q9Y2X0
RLQPKQPLRLQFGRA	MED16	741	Q9Y2X0
LKPIFPNLLVQDTGR	PCDHB4	766	Q9Y5E5
KALVARLLPFLPQDQ	PATL2	371	C9JE40
RQKLPDNLKQLFRPV	DYNC2H1	1801	Q8NCM8
VTLLRRIQPPLGFGK	CACNA1C	1566	Q13936
RFFLRLNRNGLPKAP	DOCK4	236	Q8N1I0
VNLPFGRPRVLQKNV	ENPP3	606	O14638
RRLLELGPKPEVAQQ	COPA	1126	P53621
INGRDRKQFPPILVV	COL6A5	126	A8TX70
QLRAKLPQRPLLGPL	FRAT1	226	Q92837
NPKVPVNLLRAGRIF	DYNC1H1	4131	Q14204
LQQRPGQPPRLLIYK	IGKV2-24	61	A0A0C4DH68
VRPLLKRLQQETQPF	CUL9	981	Q8IWT3
PGFTGPKRQNRILLL	CCDC168	6591	Q8NDH2
INLREVLNRFKLPPG	CAPN2	466	P17655
VNPSFLLPRLRKQLA	CAND2	966	O75155
QPGRFAKLLLRLPAL	RXRA	411	P19793
QLAKPLLRIFEPILG	POLD1	961	P28340
ELLNLLPKRGPQAFD	CASP2	86	P42575
VTLLRRIQPPLGFGK	CACNA1D	1506	Q01668
LPKNPDLRIAQLRFL	PSMD6	11	Q15008
NQLRVLPPEVGKLTR	LRRC30	81	A6NM36
PILFIIRKQQRQSPA	MED6	76	O75586
RVDALLLDLRQKFPP	MED6	176	O75586
LLDNLSRKVPLPFGV	RP1	66	P56715
AQLRLLFGIAQPQLP	PIGS	391	Q96S52
LKLRLEQRPAGEPSL	MAP3K4	631	Q9Y6R4
IEKNLLIPNGFPLER	FER1L6	226	Q2WGJ9
PPPRDFLLDIARQKN	TAF9B	86	Q9HBM6
KPNGPNLRYELLRRK	USH2A	2846	O75445
LRQGFLPLNTPVEKI	RIMBP2	926	O15034
GLQLFVKDPALRLPT	AGXT	306	P21549
LRKQLQRNAGLVPVP	SNX11	66	Q9Y5W9
LGRARVPLLPLAKNE	RPGRIP1	886	Q96KN7
QPPQFKLDPRLARLL	SMARCD1	291	Q96GM5
PIRRALQQLLFPGKA	SLC38A5	356	Q8WUX1
TPILEGFVILRKNPN	PSMD2	891	Q13200
QRRKPPGFLALVKLL	PNMA3	316	Q9UL41
QRLPLGEKLLFDPRT	PPP1R42	126	Q7Z4L9
PQFKLDPRLARLLGL	SMARCD3	261	Q6STE5
LEQAEQLLKFGLPRP	CCT8L1P	116	A6NM43
QLLKFGLPRPQLREA	CCT8L1P	121	A6NM43
QLLKAGLPRPQLREA	CCT8L2	121	Q96SF2
RDQRAQGKDIPPILR	ITGAL	741	P20701
LFDKRRLLIGQPLPN	PLK4	306	O00444
LELLQARLPRKDPAG	TRIOBP	1586	Q9H2D6
SGLQPAVRRLLQVKP	SOX30	61	O94993
RGPDSNVLLLRLPEK	ROBO4	331	Q8WZ75
VLQRPRLVAGPQFLA	ABHD1	36	Q96SE0
RVNQLSPPGKVRLDL	BRINP2	726	Q9C0B6
QLERLLNKPGLRFKP	AKR1E2	176	Q96JD6
LFENSRLLQPPKGVL	ATAD1	116	Q8NBU5
EPLRFARILLGQEPI	CILP2	486	Q8IUL8
VPLLRDPGLNLKVVQ	CHST7	261	Q9NS84
VKKLPYLPRILGRNI	CLCNKA	526	P51800
LYLKVGVNPLLRLPR	CNGB1	751	Q14028
VKKLPYLPRILGRNI	CLCNKB	526	P51801
IVRRPKLNRENFPGV	SKP2	81	Q13309
VVLFLPNPRPNIFKL	nan	76	Q6ZUT4
QEVRKLDLPVLFPNR	ZSCAN32	396	Q9NX65
LPFLQPGRLVKVKNE	MTREX	651	P42285
QRKLLERLPEAPGLS	REV3L	2206	O60673
RPNGLKLNLPGLREF	STON1	36	Q9Y6Q2
RPLGRLLPKVQEVAR	SAPCD2	286	Q86UD0
KNLLGLQNIPRPFFL	SLC26A11	171	Q86WA9
VLRIISGQQLPKPRD	PLCH2	761	O75038
PRLTLRKEGALLAPQ	TONSL	976	Q96HA7
EQPGRFAKLLLRLPA	RXRG	411	P48443
RLKRFGPNVPALLEA	SMC6	476	Q96SB8
LQLRKFGQRFLPRPG	TMDD1	156	P0DPE3
AKRPPLQSLQERGLL	ARHGAP9	521	Q9BRR9
EEQRGPLPLNKTLFL	TP53BP1	1716	Q12888
GKLGNPIVPLNIRLF	PRKDC	2131	P78527
VRIPRLRGKFNLQLP	nan	16	A8MV72
VRIPCLRGKFNLQLP	nan	46	Q8N9G6
VRIPHLRGKFNLQLP	nan	46	A8MUI8
VRIPRLRGKFNLQLP	nan	46	A8MUA0
LGQRIRDFPQQALPL	TRIM10	276	Q9UDY6
RPVPRPLNKLQGFIF	SCN7A	1231	Q01118
REQRIPLSLNAPKGL	ZBTB32	291	Q9Y2Y4
LLQRIARRPKPQQFF	TAC1	51	P20366
RNPRLRGKFNLQLPS	nan	46	A6NL46
LRPTFPGVIRQIRKN	UGGT1	481	Q9NYU2
LLQPNARKEDLFGRP	UBR5	2056	O95071
RNQLPFLRNPDILVG	MYO5B	56	Q9ULV0