Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC13A1 SLC13A5 SLC20A1	9.37e-05	81	22	3	GO:0015370
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC13A1 SLC13A5 SLC20A1	2.93e-04	119	22	3	GO:0015294
GeneOntologyMolecularFunction	metalloendopeptidase activity	MMP14 MMP16 MMP24	3.00e-04	120	22	3	GO:0004222
GeneOntologyMolecularFunction	metalloaminopeptidase activity	MMP14 MMP16	3.71e-04	26	22	2	GO:0070006
GeneOntologyMolecularFunction	symporter activity	SLC13A1 SLC13A5 SLC20A1	5.76e-04	150	22	3	GO:0015293
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC13A1 SLC13A5 SLC20A1	8.43e-04	171	22	3	GO:0015081
GeneOntologyMolecularFunction	aminopeptidase activity	MMP14 MMP16	1.02e-03	43	22	2	GO:0004177
GeneOntologyMolecularFunction	metallopeptidase activity	MMP14 MMP16 MMP24	1.32e-03	200	22	3	GO:0008237
GeneOntologyMolecularFunction	metalloexopeptidase activity	MMP14 MMP16	2.67e-03	70	22	2	GO:0008235
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC13A1 SLC13A5 SLC20A1	4.03e-03	296	22	3	GO:0015291
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC13A1 SLC13A5 SLC20A1	4.22e-03	301	22	3	GO:0022853
GeneOntologyMolecularFunction	dioxygenase activity	HIF1AN PTGS1	5.17e-03	98	22	2	GO:0051213
GeneOntologyMolecularFunction	exopeptidase activity	MMP14 MMP16	6.46e-03	110	22	2	GO:0008238
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC13A1 SLC13A5 SLC20A1 MIP	8.73e-03	758	22	4	GO:0015318
GeneOntologyBiologicalProcess	collagen catabolic process	MMP14 MMP16 MMP24	2.38e-05	53	22	3	GO:0030574
Domain	DUF3377	MMP14 MMP16 MMP24	5.67e-09	4	22	3	PF11857
Domain	Pept_M10A_metallopeptidase_C	MMP14 MMP16 MMP24	5.67e-09	4	22	3	IPR021805
Domain	Hemopexin_CS	MMP14 MMP16 MMP24	9.54e-07	17	22	3	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP14 MMP16 MMP24	1.14e-06	18	22	3	IPR016293
Domain	PG_binding_1	MMP14 MMP16 MMP24	1.60e-06	20	22	3	PF01471
Domain	Peptidoglycan-bd-like	MMP14 MMP16 MMP24	1.60e-06	20	22	3	IPR002477
Domain	Hemopexin-like_dom	MMP14 MMP16 MMP24	2.47e-06	23	22	3	IPR000585
Domain	Hemopexin	MMP14 MMP16 MMP24	2.47e-06	23	22	3	PF00045
Domain	HEMOPEXIN	MMP14 MMP16 MMP24	2.47e-06	23	22	3	PS00024
Domain	-	MMP14 MMP16 MMP24	2.47e-06	23	22	3	2.110.10.10
Domain	HEMOPEXIN_2	MMP14 MMP16 MMP24	2.47e-06	23	22	3	PS51642
Domain	Hemopexin-like_repeat	MMP14 MMP16 MMP24	2.47e-06	23	22	3	IPR018487
Domain	HX	MMP14 MMP16 MMP24	2.47e-06	23	22	3	SM00120
Domain	Pept_M10A	MMP14 MMP16 MMP24	2.47e-06	23	22	3	IPR021190
Domain	M10A_MMP	MMP14 MMP16 MMP24	2.47e-06	23	22	3	IPR033739
Domain	Peptidase_M10	MMP14 MMP16 MMP24	2.83e-06	24	22	3	PF00413
Domain	NA_SULFATE	SLC13A1 SLC13A5	3.97e-06	3	22	2	PS01271
Domain	Na/sul_symport_CS	SLC13A1 SLC13A5	3.97e-06	3	22	2	IPR031312
Domain	ZnMc	MMP14 MMP16 MMP24	5.08e-06	29	22	3	SM00235
Domain	Peptidase_Metallo	MMP14 MMP16 MMP24	5.08e-06	29	22	3	IPR006026
Domain	Na/sul_symport	SLC13A1 SLC13A5	1.32e-05	5	22	2	IPR001898
Domain	Na_sulph_symp	SLC13A1 SLC13A5	1.32e-05	5	22	2	PF00939
Domain	CYSTEINE_SWITCH	MMP14 MMP16 MMP24	1.47e-05	41	22	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP14 MMP16 MMP24	1.70e-05	43	22	3	IPR001818
Domain	CUT	ONECUT1 ONECUT3	2.77e-05	7	22	2	PF02376
Domain	CUT_dom	ONECUT1 ONECUT3	2.77e-05	7	22	2	IPR003350
Domain	CUT	ONECUT1 ONECUT3	2.77e-05	7	22	2	SM01109
Domain	CUT	ONECUT1 ONECUT3	2.77e-05	7	22	2	PS51042
Domain	MetalloPept_cat_dom	MMP14 MMP16 MMP24	1.14e-04	81	22	3	IPR024079
Domain	-	MMP14 MMP16 MMP24	1.14e-04	81	22	3	3.40.390.10
Domain	Pept_M10A_Zn_BS	MMP14 MMP16	1.38e-04	15	22	2	IPR021158
Domain	ZINC_PROTEASE	MMP14 MMP16 MMP24	2.01e-04	98	22	3	PS00142
Domain	-	ONECUT1 ONECUT3	4.57e-04	27	22	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	ONECUT1 ONECUT3	5.27e-04	29	22	2	IPR010982
Domain	-	ONECUT1 JRKL ONECUT3	4.28e-03	283	22	3	1.10.10.60
Domain	Homeodomain-like	ONECUT1 JRKL ONECUT3	6.67e-03	332	22	3	IPR009057
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP14 MMP16 MMP24	6.26e-06	29	18	3	MM15981
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP14 MMP16 MMP24	6.95e-06	30	18	3	M39652
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	MMP14 MMP16 MMP24	9.31e-06	33	18	3	M26976
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	MMP14 MMP16 MMP24	1.43e-05	38	18	3	MM14611
Pathway	REACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS	SLC13A1 SLC13A5	1.54e-05	5	18	2	MM15099
Pathway	REACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS	SLC13A1 SLC13A5	1.54e-05	5	18	2	M27354
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	MMP14 MMP16 MMP24	2.56e-05	46	18	3	M46450
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS	ONECUT1 ONECUT3	4.29e-05	8	18	2	M27123
Pathway	REACTOME_TGFBR3_PTM_REGULATION	MMP14 MMP16	6.89e-05	10	18	2	MM17232
Pathway	REACTOME_TGFBR3_PTM_REGULATION	MMP14 MMP16	8.41e-05	11	18	2	M48251
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	ONECUT1 ONECUT3	1.83e-04	16	18	2	M27121
Pathway	REACTOME_SIGNALING_BY_TGFBR3	MMP14 MMP16	3.19e-04	21	18	2	MM17231
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	MMP14 MMP16 MMP24	3.85e-04	114	18	3	MM14571
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	MMP14 MMP16 MMP24	7.01e-04	140	18	3	M587
Pathway	PID_HIF2PATHWAY	MMP14 HIF1AN	8.43e-04	34	18	2	M44
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	ONECUT1 ONECUT3	1.29e-03	42	18	2	M17541
Pathway	REACTOME_SIGNALING_BY_TGFBR3	MMP14 MMP16	1.75e-03	49	18	2	M48250
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC13A1 SLC13A5 SLC20A1	3.21e-03	238	18	3	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC13A1 SLC13A5 SLC20A1	3.65e-03	249	18	3	M5988
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	MMP14 MMP16 MMP24	4.03e-03	258	18	3	MM14572
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC13A1 SLC13A5	4.15e-03	76	18	2	MM15072
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC13A1 SLC13A5	5.05e-03	84	18	2	M27334
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	MMP14 MMP16 MMP24	6.14e-03	300	18	3	M610
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP14 MMP16 MMP24	8.78e-10	4	22	3	35062057
Pubmed	mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.	MMP14 MMP16 MMP24	2.19e-09	5	22	3	12661033
Pubmed	MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.	MMP14 MMP16 MMP24	2.19e-09	5	22	3	29196321
Pubmed	Membrane-type matrix metalloproteinases: Their functions and regulations.	MMP14 MMP16 MMP24	7.68e-09	7	22	3	25794647
Pubmed	Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.	MMP14 MMP16 MMP24	7.68e-09	7	22	3	12879005
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP14 MMP16 MMP24	1.22e-07	16	22	3	10949577
Pubmed	Matrix metalloproteinases.	MMP14 MMP16 MMP24	3.36e-07	22	22	3	10419448
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP14 MMP16 MMP24	3.36e-07	22	22	3	23421805
Pubmed	Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.	MMP14 MMP16	3.82e-07	2	22	2	18022611
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP14 MMP16 MMP24	4.41e-07	24	22	3	15734845
Pubmed	A cancer cell metalloprotease triad regulates the basement membrane transmigration program.	MMP14 MMP16	1.15e-06	3	22	2	16983145
Pubmed	Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.	MMP14 MMP16	1.15e-06	3	22	2	9119382
Pubmed	OC-3, a novel mammalian member of the ONECUT class of transcription factors.	ONECUT1 ONECUT3	1.15e-06	3	22	2	11944891
Pubmed	ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.	ONECUT1 ONECUT3	1.15e-06	3	22	2	31049588
Pubmed	OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6.	ONECUT1 ONECUT3	1.15e-06	3	22	2	9915796
Pubmed	Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.	MMP14 MMP16	1.15e-06	3	22	2	18784838
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	MMP14 MMP16 MMP24	1.55e-06	36	22	3	20587546
Pubmed	Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2.	ONECUT1 ONECUT3	2.29e-06	4	22	2	12971999
Pubmed	Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding.	MMP14 MMP16	2.29e-06	4	22	2	24970228
Pubmed	Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.	MMP14 MMP16	2.29e-06	4	22	2	15895410
Pubmed	Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters.	SLC13A1 SLC13A5	3.82e-06	5	22	2	16211368
Pubmed	The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.	MMP14 MMP16	5.72e-06	6	22	2	14645246
Pubmed	The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.	ONECUT1 ONECUT3	5.72e-06	6	22	2	15381696
Pubmed	Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.	MMP14 MMP16	8.01e-06	7	22	2	19542530
Pubmed	Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.	ONECUT1 ONECUT3	1.71e-05	10	22	2	31231191
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP14 MMP16	2.09e-05	11	22	2	10949161
Pubmed	Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse.	ONECUT1 ONECUT3	2.97e-05	13	22	2	22102297
Pubmed	Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.	ONECUT1 ONECUT3	3.46e-05	14	22	2	22534286
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	MMP14 MMP16	3.46e-05	14	22	2	20858856
Pubmed	Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development.	ONECUT1 ONECUT3	3.46e-05	14	22	2	23213462
Pubmed	Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.	ONECUT1 ONECUT3	4.56e-05	16	22	2	19800948
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP14 MMP16	4.56e-05	16	22	2	37701782
Pubmed	The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.	ONECUT1 ONECUT3	4.56e-05	16	22	2	28603487
Pubmed	Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.	ONECUT1 ONECUT3	5.81e-05	18	22	2	25794677
Pubmed	β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis.	MMP14 MIP	5.81e-05	18	22	2	28763805
Pubmed	Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.	ONECUT1 ONECUT3	5.81e-05	18	22	2	31969659
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MMP14 MMP16 MMP24 GRK1 DNAH11	7.87e-05	730	22	5	34857952
Pubmed	Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.	ONECUT1 ONECUT3	7.96e-05	21	22	2	22833130
Pubmed	Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.	ONECUT1 ONECUT3	8.76e-05	22	22	2	17400205
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	MMP14 MMP16 PTGS1	2.15e-04	186	22	3	20452482
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	MMP14 MMP16 PTGS1	2.15e-04	186	22	3	20673868
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	MMP14 MMP16 SLC20A1	4.06e-04	231	22	3	21048031
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	ONECUT1 ONECUT3	5.16e-04	53	22	2	27210758
Interaction	KISS1 interactions	MMP14 MMP16 MMP24	7.60e-07	17	22	3	int:KISS1
Interaction	MMP16 interactions	MMP14 MMP16 MMP24	9.12e-07	18	22	3	int:MMP16
Interaction	MMP24 interactions	MMP14 MMP16 MMP24	1.08e-06	19	22	3	int:MMP24
Interaction	MMP13 interactions	MMP14 MMP16 MMP24	4.98e-06	31	22	3	int:MMP13
Interaction	MMP20 interactions	MMP16 MMP24	5.09e-05	10	22	2	int:MMP20
Interaction	MMP17 interactions	MMP16 MMP24	5.09e-05	10	22	2	int:MMP17
Interaction	MMP27 interactions	MMP16 MMP24	6.22e-05	11	22	2	int:MMP27
Interaction	MMP11 interactions	MMP16 MMP24	7.46e-05	12	22	2	int:MMP11
Interaction	MMP14 interactions	MMP14 MMP16 MMP24	8.78e-05	80	22	3	int:MMP14
Interaction	MMP8 interactions	MMP16 MMP24	3.36e-04	25	22	2	int:MMP8
Interaction	MMP10 interactions	MMP16 MMP24	4.86e-04	30	22	2	int:MMP10
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	PTGS1 BRINP1	1.99e-03	138	22	2	chr9q33
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP14 MMP16 MMP24	1.14e-06	24	16	3	891
GeneFamily	CUT class homeoboxes and pseudogenes	ONECUT1 ONECUT3	2.63e-05	9	16	2	527
GeneFamily	Solute carriers	SLC13A1 SLC13A5 SLC20A1	4.69e-03	395	16	3	752
Coexpression	GSE17721_CTRL_VS_POLYIC_6H_BMDC_DN	SLC13A1 MMP14 BRINP1 EPHA1	2.12e-05	199	22	4	M3716
CoexpressionAtlas	ratio_StemCell_vs_induced-Ectoderm_top-relative-expression-ranked_1000_k-means-cluster#1	ONECUT1 SLC13A5 MMP24 BRINP1 EPHA1 DNAH11	1.16e-05	523	22	6	ratio_SC_vs_ECTO_1000_K1
Drug	diacerein	MMP14 MMP16 MMP24 PTGS1 CARD16	3.50e-09	63	22	5	CID000026248
Drug	malolactomycin D	MMP14 MMP16 MMP24	3.81e-06	32	22	3	CID006449115
Drug	pirfenidone	MMP14 MMP16 MMP24 PTGS1	8.68e-06	138	22	4	CID000040632
Drug	peroxynitrite	MMP14 MMP16 MMP24 PTGS1 CARD16	2.40e-05	373	22	5	CID000104806
Drug	CGS 27023A	MMP14 MMP16	3.20e-05	9	22	2	ctd:C097658
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	MMP14 ONECUT1 PTGS1 EPHA1	3.31e-05	194	22	4	4174_DN
Drug	Ethambutol dihydrochloride [1070-11-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A	MMP14 MMP16 ONECUT1 PTGS1	3.45e-05	196	22	4	1481_UP
Drug	Clemizole hydrochloride [1163-36-6]; Up 200; 11uM; PC3; HT_HG-U133A	MMP14 MMP16 HIF1AN CDH10	3.45e-05	196	22	4	7371_UP
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; PC3; HT_HG-U133A	MMP24 CDH10 BRINP1 MIP	3.45e-05	196	22	4	6646_UP
Drug	Bisacodyl [603-50-9]; Up 200; 11uM; HL60; HT_HG-U133A	MMP16 ONECUT1 CDH10 BRINP1	3.52e-05	197	22	4	2435_UP
Drug	Metyrapone [54-36-4]; Up 200; 17.6uM; MCF7; HT_HG-U133A	MMP24 HIF1AN PTGS1 MIP	3.59e-05	198	22	4	6447_UP
Drug	vinblastine sulfate; Down 200; 0.1uM; MCF7; HT_HG-U133A	MMP16 HIF1AN PTGS1 EPHA1	3.59e-05	198	22	4	7551_DN
Drug	Trolox [53188-07-1]; Down 200; 16uM; MCF7; HT_HG-U133A	MMP16 HIF1AN PTGS1 JRKL	3.66e-05	199	22	4	2883_DN
Drug	Gallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A	MMP14 MMP24 PTGS1 BRINP1	3.73e-05	200	22	4	5735_UP
Drug	hydroxyl radical	MMP14 MMP16 MMP24 PTGS1	4.19e-05	206	22	4	CID000157350
Drug	AC1L1GXT	MMP14 MMP16 MMP24	4.85e-05	74	22	3	CID000003890
Drug	AC1NSU5S	MMP16 MMP24 PTGS1	5.05e-05	75	22	3	CID005316299
Drug	2-phenylethylglucosinolate	MMP14 PTGS1	5.85e-05	12	22	2	CID000656554
Drug	quinacrine	MMP14 MMP16 MMP24 PTGS1	7.96e-05	243	22	4	CID000000237
Drug	hexa-1,3,5-triene	SLC13A1 MIP	8.05e-05	14	22	2	CID000016695
Drug	enantio-PAF-C16	MMP14 MMP16 MMP24 PTGS1	8.09e-05	244	22	4	CID000002499
Drug	HCT1026	PTGS1 CARD16	9.29e-05	15	22	2	CID000119387
Drug	ketorolac tromethamine	PTGS1 GRK1	9.29e-05	15	22	2	CID000084003
Drug	1,10-phenanthroline	MMP14 MMP16 MMP24 PTGS1	1.15e-04	267	22	4	CID000001318
Drug	MMI270	MMP16 MMP24	1.35e-04	18	22	2	CID000446504
Drug	ketorolac	PTGS1 GRK1	1.51e-04	19	22	2	CID000003826
Drug	NOC-9	PTGS1 CARD16	1.85e-04	21	22	2	CID000004524
Drug	felbinac	PTGS1 MIP	1.85e-04	21	22	2	CID000003332
Drug	BN 50730	MMP14 PTGS1	2.03e-04	22	22	2	CID003033963
Drug	AC1L1ICD	PTGS1 CARD16	2.23e-04	23	22	2	CID000004516
Drug	acetate	MMP14 MMP16 MMP24 PTGS1 DNAH11	2.25e-04	599	22	5	CID000000175
Drug	H2TeO4	CARD16 EPHA1	2.43e-04	24	22	2	CID000061609
Drug	Pro-leu-gly	MMP16 MMP24	2.86e-04	26	22	2	CID000169533
Drug	DA-125	MMP16 MMP24	2.86e-04	26	22	2	CID000114758
Drug	chloride	SLC13A1 LYPD4 SLC13A5 SLC20A1 PTGS1 CARD16	3.36e-04	1029	22	6	CID000000312
Drug	AC1OCF9M	PTGS1 CARD16	3.56e-04	29	22	2	CID006918304
Drug	mercuric acetate	MMP16 MMP24	3.81e-04	30	22	2	CID000015337
Drug	Vgvapg	MMP14 MMP24	4.07e-04	31	22	2	CID000124934
Drug	benzenesulfonyl	PTGS1 GRK1	4.07e-04	31	22	2	CID000012057
Drug	losartan	MMP14 MMP16 MMP24 PTGS1	4.32e-04	378	22	4	CID000003961
Drug	isoflavone	MMP14 MMP16 MMP24	4.33e-04	155	22	3	CID000072304
Drug	NO-ASA	PTGS1 CARD16	4.62e-04	33	22	2	CID000119032
Drug	carvedilol	MMP14 MMP16 MMP24	4.84e-04	161	22	3	CID000002585
Drug	1,5-isoquinolinediol	PTGS1 CARD16	4.91e-04	34	22	2	CID000001340
Drug	aldosterone	MMP14 MMP16 MMP24 PTGS1	5.19e-04	397	22	4	CID000005839
Drug	titanium	MMP14 MMP16 MMP24	5.67e-04	170	22	3	CID000023963
Drug	AC1L1DD6	MMP14 MMP16 MMP24	6.59e-04	179	22	3	CID000002299
Drug	latanoprost acid	MMP16 MMP24	6.80e-04	40	22	2	CID006441636
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	SLC13A1 MMP16 CDH10	7.14e-04	184	22	3	2686_UP
Drug	boldine	SLC13A1 PTGS1	7.14e-04	41	22	2	CID000010154
Drug	Gramine [87-52-5]; Up 200; 23uM; HL60; HT_HG-U133A	MMP14 MMP24 HIF1AN	7.84e-04	190	22	3	2143_UP
Drug	AC1MQZ6I	MMP14 MMP16 MMP24	7.84e-04	190	22	3	CID003509873
Drug	Tetrahydrozoline hydrochloride [522-48-5]; Up 200; 16.8uM; MCF7; HT_HG-U133A	MMP14 PTGS1 EPHA1	8.32e-04	194	22	3	6769_UP
Drug	Antazoline hydrochloride [2508-72-7]; Up 200; 13.2uM; HL60; HG-U133A	MMP14 HIF1AN JRKL	8.32e-04	194	22	3	1556_UP
Drug	Bumetanide [28395-03-1]; Down 200; 11uM; HL60; HT_HG-U133A	HIF1AN PTGS1 CDH10	8.45e-04	195	22	3	2409_DN
Drug	Probenecid [57-66-9]; Up 200; 14uM; MCF7; HT_HG-U133A	MMP14 MMP16 CDH10	8.45e-04	195	22	3	4771_UP
Drug	alpha-estradiol; Up 200; 0.01uM; PC3; HT_HG-U133A	MMP14 PTGS1 MIP	8.45e-04	195	22	3	4434_UP
Drug	Tranexamic acid [1197-18-8]; Down 200; 25.4uM; HL60; HG-U133A	MMP14 SLC20A1 HIF1AN	8.45e-04	195	22	3	1401_DN
Drug	Acenocoumarol [152-72-7]; Down 200; 11.4uM; MCF7; HT_HG-U133A	MMP14 PTGS1 CDH10	8.45e-04	195	22	3	2240_DN
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; PC3; HT_HG-U133A	MMP14 HIF1AN CDH10	8.45e-04	195	22	3	6303_UP
Drug	Methacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; HL60; HT_HG-U133A	MMP14 HIF1AN PTGS1	8.45e-04	195	22	3	2901_DN
Drug	Flurbiprofen [5104-49-4]; Down 200; 16.4uM; MCF7; HT_HG-U133A	MMP16 HIF1AN PTGS1	8.45e-04	195	22	3	5269_DN
Drug	trichostatin A; Up 200; 0.1uM; ssMCF7; HG-U133A	MMP24 PTGS1 MIP	8.58e-04	196	22	3	413_UP
Drug	indomethacin, USP; Up 200; 100uM; SKMEL5; HG-U133A	PTGS1 EPHA1 MIP	8.58e-04	196	22	3	503_UP
Drug	(+,-)-Synephrine [94-07-5]; Down 200; 24uM; MCF7; HT_HG-U133A	MMP16 HIF1AN EPHA1	8.58e-04	196	22	3	6798_DN
Drug	Betonicine [515-25-3]; Up 200; 25.2uM; PC3; HT_HG-U133A	MMP14 MMP24 PTGS1	8.58e-04	196	22	3	3745_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; HL60; HT_HG-U133A	HIF1AN BRINP1 MIP	8.58e-04	196	22	3	2560_UP
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; HL60; HT_HG-U133A	MMP14 MMP16 MIP	8.58e-04	196	22	3	2511_UP
Drug	Citalopram hydrobromide [59729-32-7]; Up 200; 1uM; PC3; HT_HG-U133A	SLC13A1 ONECUT1 MMP24	8.58e-04	196	22	3	3820_UP
Drug	Adamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	MMP14 ONECUT1 MIP	8.58e-04	196	22	3	4806_UP
Drug	Nalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; HL60; HG-U133A	MMP14 HIF1AN PTGS1	8.58e-04	196	22	3	1379_DN
Drug	AC1L1B55	MMP14 MMP16 MMP24 PTGS1	8.58e-04	454	22	4	CID000001287
Drug	ginsenoside Rh2	PTGS1 CARD16	8.60e-04	45	22	2	CID000119307
Drug	Azaperone [1649-18-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	HIF1AN PTGS1 EPHA1	8.70e-04	197	22	3	3573_DN
Drug	2-propylpentanoic acid; Up 200; 200uM; PC3; HT_HG-U133A	MMP14 BRINP1 MIP	8.70e-04	197	22	3	4438_UP
Drug	Hydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A	MMP14 MMP16 BRINP1	8.70e-04	197	22	3	2889_UP
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Down 200; 14.6uM; MCF7; HT_HG-U133A	MMP16 HIF1AN PTGS1	8.70e-04	197	22	3	2892_DN
Drug	Tracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; PC3; HT_HG-U133A	MMP14 MMP16 MMP24	8.70e-04	197	22	3	6619_UP
Drug	Amyleine hydrochloride [532-59-2]; Up 200; 14.8uM; PC3; HG-U133A	MMP14 HIF1AN EPHA1	8.70e-04	197	22	3	1909_UP
Drug	Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; PC3; HT_HG-U133A	SLC13A1 MMP16 EPHA1	8.70e-04	197	22	3	4598_UP
Drug	Pregnenolone [145-13-1]; Up 200; 12.6uM; MCF7; HT_HG-U133A	MMP16 CDH10 EPHA1	8.70e-04	197	22	3	4802_UP
Drug	Idazoxan hydrochloride [79944-56-2]; Down 200; 16.6uM; PC3; HT_HG-U133A	MMP14 BRINP1 EPHA1	8.70e-04	197	22	3	6747_DN
Drug	Etofylline [519-37-9]; Up 200; 17.8uM; MCF7; HT_HG-U133A	SLC13A1 PTGS1 MIP	8.70e-04	197	22	3	5467_UP
Drug	Memantine Hydrochloride [41100-52-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	CDH10 EPHA1 MIP	8.70e-04	197	22	3	4135_UP
Drug	Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	ONECUT1 HIF1AN MIP	8.70e-04	197	22	3	2328_DN
Drug	Prochlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; PC3; HT_HG-U133A	MMP16 BRINP1 EPHA1	8.70e-04	197	22	3	6664_UP
Drug	Penbutolol sulfate [38363-32-5]; Up 200; 5.8uM; MCF7; HT_HG-U133A	MMP14 MMP16 EPHA1	8.70e-04	197	22	3	7476_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A_EA	MMP16 HIF1AN JRKL	8.70e-04	197	22	3	1017_DN
Drug	WY-14643; Down 200; 100uM; MCF7; HG-U133A	MMP16 MMP24 MIP	8.83e-04	198	22	3	368_DN
Drug	Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; MCF7; HT_HG-U133A	PTGS1 CDH10 BRINP1	8.83e-04	198	22	3	5680_UP
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	MMP14 HIF1AN PTGS1	8.83e-04	198	22	3	5545_DN
Drug	Oxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; HL60; HG-U133A	MMP14 HIF1AN JRKL	8.83e-04	198	22	3	1553_UP
Drug	Ozagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; MCF7; HT_HG-U133A	MMP14 HIF1AN CDH10	8.83e-04	198	22	3	5983_UP
Drug	Gabexate mesilate [56974-61-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	MMP14 PTGS1 EPHA1	8.83e-04	198	22	3	7357_UP
Drug	Prednisone [53-03-2]; Up 200; 11.2uM; PC3; HG-U133A	MMP14 HIF1AN BRINP1	8.83e-04	198	22	3	1897_UP
Drug	Sulfamethoxypyridazine [80-35-3]; Up 200; 14.2uM; PC3; HT_HG-U133A	MMP24 PTGS1 BRINP1	8.83e-04	198	22	3	3711_UP
Drug	Gibberellic acid [77-06-5]; Up 200; 11.6uM; HL60; HT_HG-U133A	SLC13A1 CDH10 BRINP1	8.83e-04	198	22	3	2910_UP
Drug	Estropipate [7280-37-7]; Up 200; 9.2uM; HL60; HT_HG-U133A	MMP16 MMP24 BRINP1	8.83e-04	198	22	3	2506_UP
Drug	Chlorhexidine [55-56-1]; Up 200; 8uM; PC3; HT_HG-U133A	MMP14 EPHA1 GRK1	8.83e-04	198	22	3	6302_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; PC3; HT_HG-U133A	MMP14 BRINP1 MIP	8.83e-04	198	22	3	3728_UP
Disease	Kohlschutter-Tonz syndrome (implicated_via_orthology)	SLC13A1 SLC13A5	5.30e-06	5	22	2	DOID:0111668 (implicated_via_orthology)
Disease	alcohol-related neurodevelopmental disorder (implicated_via_orthology)	SLC13A1 SLC13A5	1.48e-05	8	22	2	DOID:0050667 (implicated_via_orthology)
Disease	asphyxia neonatorum	CARD16 BRINP1	2.60e-04	32	22	2	EFO_1000824
Disease	Esophageal Neoplasms	MMP14 PTGS1	1.54e-03	78	22	2	C0014859
Disease	Malignant neoplasm of esophagus	MMP14 PTGS1	1.54e-03	78	22	2	C0546837
Disease	unipolar depression, bipolar disorder	CARD16 BRINP1	5.99e-03	156	22	2	EFO_0003761, MONDO_0004985
Disease	epilepsy (implicated_via_orthology)	SLC13A1 SLC13A5	6.52e-03	163	22	2	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLWNFVERWLIALAS	ABHD13	6	Q7L211
QWWNFLREATIMGQF	EPHA1	666	P21709
MNWRFVELLYFLFIW	BRINP1	1	O60477
KWSWMFQEHLLRFVI	DNAH11	1126	Q96DT5
MWELRSASFWRAIFA	MIP	1	P30301
FKERWFWRVRNNQVM	MMP14	336	P50281
RGEMFVFKDRWFWRL	MMP24	391	Q9Y5R2
RKIVMDFLGFNWNWI	HIF1AN	156	Q9NWT6
TFRRMWKWLQEPEFQ	ONECUT1	346	Q9UBC0
RFRAVAFHNWKWLLM	LYPD4	36	Q6UWN0
WMDLSIFRQWFDKIF	JRKL	256	Q9Y4A0
RWFWEFVNATFIREM	PTGS1	96	P23219
RQKRGWMWNQFFLLE	CDH10	51	Q9Y6N8
FLRFLQWKWLEAQPM	GRK1	171	Q15835
ISDWRMLWTFDNRFL	FDXACB1	501	Q9BRP7
IWLQWLFLGFNFKEM	SLC13A1	301	Q9BZW2
LFAWLWLQFVYMRFN	SLC13A5	266	Q86YT5
AVDWRLFRNIFMAWF	SLC20A1	641	Q8WUM9
MQWLFLRTNFIERFW	CARD16	151	Q5EG05
FRRMWKWLQEPEFQR	ONECUT3	376	O60422
EMFVFKDQWFWRVRN	MMP16	356	P51512
LDMFSNWDKWLSRRF	TBC1D10B	336	Q4KMP7