Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoneurodegeneration

DOCK3 CACNA1A PCARE VAC14 SETX SLC4A7 HERC2 CNGA1

3.00e-05468388MP:0002229
MousePhenophotoreceptor outer segment degeneration

PCARE SLC4A7 CNGA1

5.18e-0527383MP:0008584
DomainARM-type_fold

MON2 DOCK3 VAC14 FRYL RIC8B DIAPH3 XPO1 TRRAP RTTN

1.17e-07339469IPR016024
DomainARM-like

MON2 VAC14 FRYL RIC8B SETX XPO1 TRRAP RTTN

2.79e-07270468IPR011989
Domain-

MON2 VAC14 FRYL RIC8B XPO1 TRRAP RTTN

1.10e-062224671.25.10.10
Domain-

PAPOLB PAPOLA

1.78e-0534623.30.70.590
DomainPAP_central

PAPOLB PAPOLA

1.78e-053462PF04928
DomainPAP_RNA-bind

PAPOLB PAPOLA

1.78e-053462PF04926
DomainPolA_pol_cen_dom

PAPOLB PAPOLA

1.78e-053462IPR007012
DomainPolA_pol_RNA-bd_dom

PAPOLB PAPOLA

1.78e-053462IPR007010
DomainPolyA_polymerase

PAPOLB PAPOLA

1.78e-053462IPR014492
DomainNuclTrfase_I_C

PAPOLB PAPOLA

1.78e-053462IPR011068
DomainNTP_transf_2

PAPOLB PAPOLA

3.22e-0411462PF01909
DomainPolymerase_NTP_transf_dom

PAPOLB PAPOLA

3.22e-0411462IPR002934
DomainHECT

HERC2 SMURF2

2.00e-0327462PF00632
DomainHECTc

HERC2 SMURF2

2.00e-0327462SM00119
DomainHECT_dom

HERC2 SMURF2

2.00e-0327462IPR000569
DomainHECT

HERC2 SMURF2

2.00e-0327462PS50237
DomainIon_trans_dom

CACNA1A CNGA1 SCN4A

2.78e-03114463IPR005821
DomainIon_trans

CACNA1A CNGA1 SCN4A

2.78e-03114463PF00520
DomainMAGE

MAGEA6 MAGED1

3.17e-0334462SM01373
DomainMAGE

MAGEA6 MAGED1

3.54e-0336462PS50838
DomainMAGE

MAGEA6 MAGED1

3.54e-0336462PF01454
DomainMHD_dom

MAGEA6 MAGED1

3.54e-0336462IPR002190
Pubmed

Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.

PAPOLB PAPOLA

1.87e-06248212471261
Pubmed

Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32.

XPO1 NUP88

5.59e-0634829205132
Pubmed

mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions.

DIAPH3 CXCR4

5.59e-06348228115158
Pubmed

Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms.

PAPOLB PAPOLA

5.59e-0634828628305
Pubmed

Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export.

XPO1 NUP88

5.59e-06348216675447
Pubmed

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.

XPO1 NUP88

5.59e-0634829049309
Pubmed

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

XPO1 TRRAP NUP88

7.89e-062848329653964
Pubmed

Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export.

XPO1 NUP88

1.12e-05448215239126
Pubmed

Tat-dependent occlusion of the HIV poly(A) site.

PAPOLB PAPOLA

1.12e-0544828491200
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MON2 DOCK3 VAC14 FRYL HERC2 TRRAP TESK1 SMURF2 RTTN

1.76e-05110548935748872
Pubmed

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

CYLD TNFRSF11A

2.79e-05648218382763
Pubmed

Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.

CYLD SENP6

2.79e-05648223825957
Pubmed

Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2.

XPO1 SMURF2

2.79e-05648227197155
Pubmed

25 years of HIV-1 research - progress and perspectives.

XPO1 CXCR4

6.67e-05948218976462
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

CYLD ARHGAP5 FRYL SETX SLC4A7 PRR5L PAPOLA NCKAP1L

1.08e-04108448811544199
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

CYLD XPO1 MAGED1 HERC2

1.18e-0418248431067453
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

CHL1 GREB1 CRACR2B FBXO47 MACROD2 NCKAP1L PTDSS1

1.20e-0481448723251661
Pubmed

Host proteins involved in HIV infection: new therapeutic targets.

XPO1 CXCR4

1.22e-041248220018238
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

MON2 CYLD SENP6 SETX DIAPH3 MAGED1

1.53e-0458848638580884
Pubmed

Functional proteomics mapping of a human signaling pathway.

ARHGAP5 APLP2 DIAPH3 HERC2 PAPOLA SMURF2

1.57e-0459148615231748
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

FRYL XPO1 HERC2 PTDSS1

1.76e-0420248433005030
Pubmed

Reverse two-hybrid screening to analyze protein-protein interaction of HIV-1 viral and cellular proteins.

XPO1 CXCR4

1.94e-041548219020832
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

CYLD XPO1 HERC2

2.41e-048748317148452
Pubmed

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

XPO1 NUP88

2.50e-041748210668806
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

SETX HERC2 TRRAP NUP88

3.96e-0425048433536335
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

APLP2 MAGED1 HERC2 ATP11B TRRAP RTTN

4.48e-0471948635337019
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A ARHGAP5 TBC1D10B MAGED1 HERC2

4.91e-0447548531040226
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

SLC4A7 XPO1 HERC2 PTDSS1

5.21e-0426948429511261
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HERC2 SMURF2

5.93e-042648226949039
Pubmed

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.

VAC14 HERC2

8.45e-043148222261722
Pubmed

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

MAGEA6 MAGED1

9.01e-043248220864041
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

MON2 DOCK3 CYLD CACNA1A SLC4A7 MAGED1 NUP88

9.04e-04113948736417873
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

XPO1 TRRAP

9.58e-043348232140074
Pubmed

Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.

MAGEA6 MAGED1

9.58e-043348231143371
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CYLD TBC1D10B FRYL SETX SLC4A7 TESK1

1.14e-0386148636931259
Pubmed

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

MON2 FRYL XPO1

1.18e-0315048322678362
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

GREB1 PAPOLA TRRAP NUP88

1.26e-0334148432971831
Pubmed

Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.

COL6A5 CXCR4

1.27e-033848225572963
InteractionEFNB1 interactions

MON2 SETX XPO1 FHIP2A CXCR4 SMURF2

2.08e-05255456int:EFNB1
InteractionMTHFD1L interactions

CYLD PAPOLB MAGED1 PAPOLA TRRAP

2.97e-05162455int:MTHFD1L
InteractionCNTROB interactions

CYLD SETX XPO1 TRRAP NUP88

3.34e-05166455int:CNTROB
InteractionVASP interactions

CYLD ARHGAP5 PCARE TBC1D10B XPO1 MAGED1

4.62e-05294456int:VASP
InteractionCOL6A5 interactions

CYLD COL6A5

4.85e-055452int:COL6A5
GeneFamilyMAGE family

MAGEA6 MAGED1

1.39e-03402521136
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

CYLD SENP6 FRYL SETX SLC4A7 XPO1 ATP11B PAPOLA FHIP2A CXCR4 SMURF2 NCKAP1L PTDSS1

1.85e-0614924813M40023
CoexpressionALONSO_METASTASIS_NEURAL_UP

MAGEA6 APLP2 SETX

4.61e-0618483M19437
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

APPBP2 FRYL SLC4A7 XPO1 ATP11B TRRAP SMURF2

2.11e-05466487M13522
CoexpressionGSE22886_NAIVE_TCELL_VS_NKCELL_DN

MON2 FRYL SETX PRR5L SMURF2

3.08e-05198485M4415
CoexpressionGSE14350_TREG_VS_TEFF_UP

MON2 ARHGAP5 APPBP2 RIC8B SMURF2

3.15e-05199485M3417
CoexpressionGSE22103_LPS_VS_GMCSF_AND_IFNG_STIM_NEUTROPHIL_UP

CYLD APLP2 DIAPH3 MAGED1 RTTN

3.23e-05200485M7795
CoexpressionGSE32986_UNSTIM_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_UP

TBC1D10B TNFRSF11A PRR5L MAGED1 RTTN

3.23e-05200485M8608
CoexpressionGSE40666_NAIVE_VS_EFFECTOR_CD8_TCELL_UP

CHL1 APPBP2 GREB1 XPO1 TLE2

3.23e-05200485M9203
CoexpressionFEVR_CTNNB1_TARGETS_DN

ARHGAP5 SLC37A2 APPBP2 SLC4A7 DIAPH3 XPO1 PAPOLA

6.38e-05555487M2343
CoexpressionSHEN_SMARCA2_TARGETS_UP

SENP6 ARHGAP5 APPBP2 SETX XPO1 HERC2

1.27e-04429486M29
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

APPBP2 FRYL SETX SLC4A7 XPO1 ATP11B TRRAP SMURF2

1.48e-04856488M4500
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

APLP2 CXCR4 NUP88 MACROD2

5.18e-051904840724665ac8238f2383c3a929d89abf4a48ec2420
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 DOCK3 SLC4A7 DIAPH3

5.29e-051914842fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 SLC4A7 DIAPH3 MACROD2

5.29e-051914845a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 SLC4A7 DIAPH3 MACROD2

5.29e-051914849032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 SLC4A7 DIAPH3 MACROD2

5.29e-0519148455ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 SLC4A7 DIAPH3 MACROD2

5.29e-051914845717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellT_cells-Central_memory_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

CYLD ARHGAP5 CXCR4 TLE2

5.29e-0519148425dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCellNS-critical-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CHL1 CRACR2B MAGED1 TLE2

5.62e-051944842172d951896265243d14996eacce5aab5e14e26e
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A FRYL SLC4A7 MAGED1

5.73e-051954843e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A FRYL SLC4A7 MAGED1

5.73e-051954847796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MON2 FRYL SLC4A7 RTTN

6.20e-05199484f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellMild/Remission-B_naive-9|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

APLP2 CXCR4 NUP88 MACROD2

6.20e-051994840451b1536be3725a520bfdd2b3dff133bea812e8
ToppCellmLN-(2)_B_cell-(23)_Follicular_B_cell|mLN / shred on region, Cell_type, and subtype

CHL1 APLP2 CXCR4 MACROD2

6.33e-05200484659b49eeeb3e96b0a52663e60336ca4d76c83cfc
ToppCellMS-Multiple_Sclerosis-Lymphocyte-B-B_naive|Multiple_Sclerosis / Disease, condition lineage and cell class

CHL1 CXCR4 NUP88 MACROD2

6.33e-052004844d16545608aa4289a5e406512100c617ccee6a97
ToppCellmLN-B_cell-Follicular_B_cell|mLN / Region, Cell class and subclass

CHL1 APLP2 CXCR4 MACROD2

6.33e-052004847f5dbd06f8643230dba45d6fa0258a13cb71f681
ToppCellCaecum-B_cell-Follicular_B_cell|Caecum / Region, Cell class and subclass

CHL1 APLP2 CXCR4 MACROD2

6.33e-052004845908e598c248ab89e576750767e9502385ee6322
ToppCellCaecum-(2)_B_cell-(23)_Follicular_B_cell|Caecum / shred on region, Cell_type, and subtype

CHL1 APLP2 CXCR4 MACROD2

6.33e-0520048468ac9006a88e87c6b1f779ddc1e1a42cc81dc35e
ToppCellmild-B_naive|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CHL1 CXCR4 NUP88 MACROD2

6.33e-05200484d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCell(23)_Follicular_B_cell|World / shred on Cell_type and subtype

CHL1 APLP2 CXCR4 MACROD2

6.83e-05204484b92212322271740ed282b495c33f15455a9d758a
Diseaseamino acid measurement

SENP6 SETX PRR5L SCN4A MACROD2 PTDSS1

5.47e-04678456EFO_0005134
Diseaseosteoporosis (is_implicated_in)

TNFRSF11A CXCR4

1.03e-0331452DOID:11476 (is_implicated_in)
Diseasestomach cancer (is_marker_for)

TNFRSF11A XPO1 CXCR4

1.34e-03142453DOID:10534 (is_marker_for)
Diseasecolorectal carcinoma (is_marker_for)

XPO1 CXCR4

1.46e-0337452DOID:0080199 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
IGIFCFEAGIKIIAL

CACNA1A

141

O00555
IDSFILLEIIKQGCE

CXCR4

261

P61073
LGSEFCELEVFAKVL

APPBP2

56

Q92624
EEKKIDRFFCIVEGL

DIAPH3

316

Q9NSV4
FKCLVGEFVSDVLLV

APLP2

131

Q06481
EEAFVPVIKLCFDGI

PAPOLB

151

Q9NRJ5
FLIIILAIIAKEGDC

MAGEA6

201

P43360
EIIERACFVLEKKFG

MAGED1

511

Q9Y5V3
TILKGEILLLECFAE

CHL1

251

O00533
LDLGSFEKVDFLICI

GREB1

686

Q4ZG55
FFKVLVALACDLELD

HERC2

3846

O95714
LAVDFIFCLVLVEVL

FRYL

121

O94915
EEEYKVACLLLIFLA

NCKAP1L

991

P55160
ECEIFLSLLVKFLDA

MON2

331

Q7Z3U7
EIIKGILFLNEACLF

PPP4R3C

196

Q6ZMV5
LFFVEEKIKLCEGEN

PRR5L

106

Q6MZQ0
EAFVPVIKLCFDGIE

PAPOLA

151

P51003
VIKLCFDGIEIDILF

PAPOLA

156

P51003
GVVEFSLCLLFAKLV

SLC37A2

296

Q8TED4
DELKEFLLKIFCVFR

DOCK3

971

Q8IZD9
DCKRITLLDVVFVLD

COL6A5

806

A8TX70
ELFLLCDKEAKGFIT

CRACR2B

36

Q8N4Y2
ELARLVVFLALVCEK

FBXO47

351

Q5MNV8
TLLEGVIVLEEFCKE

FHIP2A

736

Q5W0V3
VIVLEEFCKELAAIA

FHIP2A

741

Q5W0V3
EDCGVFVALDKLELI

CYLD

191

Q9NQC7
FLLLCFEEISQLLGE

PCARE

221

A6NGG8
FECVELELALKLASG

NUP88

366

Q99567
VDRIIFCVFLEVDFK

MACROD2

216

A1Z1Q3
VTEVGALFCLLLFDE

RTTN

941

Q86VV8
FLAEVDKLVQLIECP

VAC14

661

Q08AM6
ICIIFIYEALEKLFD

SLC4A7

731

Q9Y6M7
CLDILFALTKEVLGD

SCN4A

1676

P35499
EFLFVLCKERVDSLL

RIC8B

426

Q9NVN3
EVLLCLFKVIELGLL

SETX

191

Q7Z333
LFVEKCVEFIEDTGL

ARHGAP5

1276

Q13017
FADCEAGLLVELVLK

CNGA1

476

P29973
VTCLFLDIIKKVFDR

ATP11B

1081

Q9Y2G3
TFDEKELELIICGLG

SMURF2

616

Q9HAU4
FLVTVIKDLLGLCEQ

XPO1

516

O14980
EPVIFCLDFIKIQLD

SENP6

461

Q9GZR1
CEGVKIIFRVALVLL

TBC1D10B

546

Q4KMP7
EKADVFAFGIVLCEL

TESK1

236

Q15569
FVLETEDCVFIKELL

REP15

201

Q6BDI9
FCLLVEELIEAGVVQ

TRBV11-3

11

A0A5A6
ILEICDRIKEEFQFL

TLE2

21

Q04725
VFGVIGFLEAIVCIK

PTDSS1

356

P48651
ELCKIGEVALAVIFD

TRRAP

1106

Q9Y4A5
LFGTVLESKVCILLD

VWA3A

951

A6NCI4
ACEGVLLLTLEEKTF

TNFRSF11A

281

Q9Y6Q6