Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LIM	LMO1 ISL2 ISL1 LHX8	1.38e-04	69	71	4	PF00412
Domain	-	LMO1 ISL2 ISL1 LHX8	1.45e-04	70	71	4	2.10.110.10
Domain	Znf_LIM	LMO1 ISL2 ISL1 LHX8	1.54e-04	71	71	4	IPR001781
Domain	LIM_DOMAIN_1	LMO1 ISL2 ISL1 LHX8	1.54e-04	71	71	4	PS00478
Domain	LIM_DOMAIN_2	LMO1 ISL2 ISL1 LHX8	1.54e-04	71	71	4	PS50023
Domain	LIM	LMO1 ISL2 ISL1 LHX8	1.54e-04	71	71	4	SM00132
Domain	ARM-like	COPB1 COPG1 BTAF1 WDFY3 HECTD1 TARBP1	5.63e-04	270	71	6	IPR011989
Domain	PH_dom-like	ARHGEF28 RABGAP1L BTK ARHGEF9 TBC1D2 WDFY3 FRMPD3	1.16e-03	426	71	7	IPR011993
Domain	Clathrin/coatomer_adapt-like_N	COPB1 COPG1	1.45e-03	15	71	2	IPR002553
Domain	Adaptin_N	COPB1 COPG1	1.45e-03	15	71	2	PF01602
Domain	-	COPB1 COPG1 BTAF1 WDFY3 HECTD1	1.56e-03	222	71	5	1.25.10.10
Domain	ARM-type_fold	COPB1 COPG1 BTAF1 WDFY3 HECTD1 TARBP1	1.82e-03	339	71	6	IPR016024
Domain	Znf_C2H2-like	ZNF555 ZNF532 ZNF549 ZFHX2 ZNF622 ZNF740 ZBTB12 BCL6 PRDM15	3.10e-03	796	71	9	IPR015880
Domain	Znf_C2H2	ZNF555 ZNF532 ZNF549 ZFHX2 ZNF622 ZNF740 ZBTB12 BCL6 PRDM15	3.34e-03	805	71	9	IPR007087
Domain	ZnF_C2H2	ZNF555 ZNF532 ZNF549 ZFHX2 ZNF622 ZNF740 ZBTB12 BCL6 PRDM15	3.42e-03	808	71	9	SM00355
Domain	-	ZNF555 ZNF532 ZNF549 ZFHX2 ZNF740 ZBTB12 BCL6 PRDM15	4.14e-03	679	71	8	3.30.160.60
Domain	-	CNOT6L OCRL	4.37e-03	26	71	2	3.60.10.10
Domain	Exo_endo_phos	CNOT6L OCRL	4.37e-03	26	71	2	PF03372
Domain	Endo/exonuclease/phosphatase	CNOT6L OCRL	4.70e-03	27	71	2	IPR005135
Domain	Znf_C2H2/integrase_DNA-bd	ZNF555 ZNF532 ZNF549 ZFHX2 ZNF740 ZBTB12 BCL6 PRDM15	4.72e-03	694	71	8	IPR013087
Domain	ZnF_U1	ZFHX2 ZNF622	5.41e-03	29	71	2	SM00451
Domain	Znf_U1	ZFHX2 ZNF622	5.41e-03	29	71	2	IPR003604
Domain	Homeobox_CS	ZFHX2 ISL2 ISL1 LHX8	5.51e-03	186	71	4	IPR017970
Pubmed	A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.	ISL2 ISL1 NOS1	2.84e-07	7	71	3	14766174
Pubmed	GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling.	ESRRG ISL2 ISL1 NOS1	4.20e-07	30	71	4	21943603
Pubmed	LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons.	ISL1 LHX8 NOS1	9.68e-07	10	71	3	19855026
Pubmed	PRC1 sustains the integrity of neural fate in the absence of PRC2 function.	ISL2 ISL1 LHX8 NOS1	1.12e-06	38	71	4	34994686
Pubmed	Wnt7A identifies embryonic γ-motor neurons and reveals early postnatal dependence of γ-motor neurons on a muscle spindle-derived signal.	ESRRG ISL2 ISL1	1.33e-06	11	71	3	22723712
Pubmed	Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord.	ISL2 ISL1 NOS1	1.33e-06	11	71	3	17492640
Pubmed	Cell type-selective expression of the zinc finger-containing gene Nolz-1/Zfp503 in the developing mouse striatum.	ISL1 LHX8 NOS1	1.77e-06	12	71	3	23684982
Pubmed	Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.	LMO1 ISL2 ISL1 LHX8	2.23e-06	45	71	4	23193182
Pubmed	Translational attenuation and retinal degeneration in mice with an active integrated stress response.	PDE6B CEP290	4.11e-06	2	71	2	29706649
Pubmed	Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin.	COPB1 OCRL	4.11e-06	2	71	2	1840503
Pubmed	Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.	ISL2 ISL1 NOS1	4.48e-06	16	71	3	19800948
Pubmed	Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.	ESRRG ISL2 ISL1	9.06e-06	20	71	3	24776795
Pubmed	The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.	ISL2 ISL1 NOS1	9.06e-06	20	71	3	35177643
Pubmed	Nuclear Organization in the Spinal Cord Depends on Motor Neuron Lamination Orchestrated by Catenin and Afadin Function.	ISL2 ISL1 NOS1	9.06e-06	20	71	3	29444423
Pubmed	Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.	ISL2 ISL1 NOS1	1.06e-05	21	71	3	22833130
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ZMYND11 PMS2 PURB AMOTL1 CEP290 GCDH PRDM15 CXXC1 TARBP1	1.11e-05	689	71	9	36543142
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZMYND11 MIS18BP1 CNOT6L LMO1 ESRRG ISL2 ISL1 BCL6 GMEB2 CXXC1	1.14e-05	877	71	10	20211142
Pubmed	Glycine release from radial cells modulates the spontaneous activity and its propagation during early spinal cord development.	ISL2 ISL1	1.23e-05	3	71	2	20053920
Pubmed	Differential Islet-1 expression among lumbosacral spinal motor neurons in prenatal mouse.	ISL2 ISL1	1.23e-05	3	71	2	19236857
Pubmed	Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.	COPB1 COPG1	1.23e-05	3	71	2	12134073
Pubmed	Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord.	ISL2 ISL1	1.23e-05	3	71	2	9100133
Pubmed	ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis.	ISL2 ISL1	1.23e-05	3	71	2	26951213
Pubmed	Islet-1 expression in thoracic spinal motor neurons in prenatal mouse.	ISL2 ISL1	1.23e-05	3	71	2	21651972
Pubmed	Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.	COPB1 COPG1	1.23e-05	3	71	2	10720466
Pubmed	A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.	HLA-DPB1 ZBTB12	1.23e-05	3	71	2	21764829
Pubmed	Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons.	ISL2 ISL1	1.23e-05	3	71	2	21339182
Pubmed	Emergence of sigh rhythmogenesis in the embryonic mouse.	ISL2 ISL1	1.23e-05	3	71	2	24591570
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ESRRG ISL2 ZNF740 ZBTB12 ISL1 BCL6 LHX8 GMEB2	1.53e-05	544	71	8	28473536
Pubmed	Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.	ISL2 ISL1 NOS1	1.82e-05	25	71	3	29379870
Pubmed	LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.	ISL2 ISL1 LHX8	1.82e-05	25	71	3	19304889
Pubmed	Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.	ISL2 ISL1 NOS1	2.05e-05	26	71	3	28684471
Pubmed	Generation and characterization of Rgs4 mutant mice.	ISL2 ISL1	2.46e-05	4	71	2	15870291
Pubmed	Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord.	ISL1 NOS1	2.46e-05	4	71	2	19306865
Pubmed	3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide.	NPHP3 CEP290	2.46e-05	4	71	2	22832925
Pubmed	Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria.	PDE6B CEP290	2.46e-05	4	71	2	26747773
Pubmed	Robo1 and 2 Repellent Receptors Cooperate to Guide Facial Neuron Cell Migration and Axon Projections in the Embryonic Mouse Hindbrain.	ISL2 ISL1	2.46e-05	4	71	2	30685539
Pubmed	Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome.	ISL2 ISL1	2.46e-05	4	71	2	18272695
Pubmed	KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity.	ISL2 ISL1	2.46e-05	4	71	2	26303204
Pubmed	Migratory pathway of sympathetic preganglionic neurons in normal and reeler mutant mice.	ISL1 NOS1	2.46e-05	4	71	2	12687699
Pubmed	Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development.	LMO1 ISL1	2.46e-05	4	71	2	8876198
Pubmed	Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system.	FLII OPTN	2.46e-05	4	71	2	10366446
Pubmed	Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.	ISL2 ISL1	2.46e-05	4	71	2	22025611
Pubmed	A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis.	ISL2 ISL1	2.46e-05	4	71	2	17468498
Pubmed	Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice.	ISL2 ISL1	2.46e-05	4	71	2	9486801
Pubmed	Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight.	ISL2 ISL1	2.46e-05	4	71	2	36353228
Pubmed	Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.	ISL2 ISL1	2.46e-05	4	71	2	27161150
Pubmed	Motor neuron position and topographic order imposed by β- and γ-catenin activities.	ISL2 ISL1 NOS1	2.87e-05	29	71	3	22036570
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	LIG3 OPTN CNOT6L COPB1 COPG1 HLA-DPB1 PURB ZNF622 ISL2 ZNF740 GCDH BTAF1	3.23e-05	1440	71	12	30833792
Pubmed	Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects.	ISL2 ISL1	4.09e-05	5	71	2	10862153
Pubmed	Sonic hedgehog regulates the position of the trigeminal ganglia.	ISL2 ISL1	4.09e-05	5	71	2	14499653
Pubmed	Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype.	ISL2 ISL1	4.09e-05	5	71	2	17208219
Pubmed	Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.	OCRL INPP5F	4.09e-05	5	71	2	25869668
Pubmed	Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells.	ISL2 ISL1	4.09e-05	5	71	2	29761490
Pubmed	Expression patterns of Hox10 paralogous genes during lumbar spinal cord development.	ISL2 ISL1	4.09e-05	5	71	2	16495162
Pubmed	Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene.	ISL2 ISL1	4.09e-05	5	71	2	9806916
Pubmed	Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons.	ISL2 ISL1	4.09e-05	5	71	2	10887087
Pubmed	Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control.	ISL2 ISL1	4.09e-05	5	71	2	37172092
Pubmed	Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice.	ISL2 ISL1	4.09e-05	5	71	2	24885435
Pubmed	Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells.	ISL2 ISL1	4.09e-05	5	71	2	9000074
Pubmed	The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.	ISL2 ISL1	4.09e-05	5	71	2	28583412
Pubmed	Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.	ISL2 ISL1 NOS1	4.26e-05	33	71	3	18662545
Pubmed	The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.	ISL2 ISL1 LHX8	4.66e-05	34	71	3	25631876
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	FLII MIS18BP1 MAP7D3 PPP1R15B PURB ZNF622 GCDH NUF2 OCRL ZZEF1 RHOT1 STRIP1	4.67e-05	1496	71	12	32877691
Pubmed	Global control of motor neuron topography mediated by the repressive actions of a single hox gene.	ISL2 ISL1 NOS1	5.55e-05	36	71	3	20826310
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII PMS2 COPB1 ZNF532 CEP290 DEF8 KCNAB2 WDFY3 HECTD1 UAP1L1 TARBP1	5.62e-05	1285	71	11	35914814
Pubmed	Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex.	ISL2 ISL1	6.13e-05	6	71	2	19578380
Pubmed	Necdin protects embryonic motoneurons from programmed cell death.	ISL2 ISL1	6.13e-05	6	71	2	21912643
Pubmed	Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.	ISL2 ISL1	6.13e-05	6	71	2	16738228
Pubmed	Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration.	PDE6B CEP290	6.13e-05	6	71	2	26139610
Pubmed	Identification and characterization of novel isoforms of COP I subunits.	COPB1 COPG1	6.13e-05	6	71	2	11056392
Pubmed	RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.	COPB1 COPG1	6.13e-05	6	71	2	10982407
Pubmed	Generation of a novel functional neuronal circuit in Hoxa1 mutant mice.	ISL2 ISL1	6.13e-05	6	71	2	11466434
Pubmed	Developmental specification of forebrain cholinergic neurons.	ISL1 LHX8	6.13e-05	6	71	2	27847324
Pubmed	SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.	FLII OTUD4	6.13e-05	6	71	2	34060252
Pubmed	Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.	PDE6B ISL1	6.13e-05	6	71	2	36260685
Pubmed	Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes.	ISL2 ISL1	6.13e-05	6	71	2	10864958
Pubmed	LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons.	ISL2 ISL1	6.13e-05	6	71	2	38433925
Pubmed	Regulation of continuous but complex expression pattern of Six1 during early sensory development.	ISL2 ISL1	6.13e-05	6	71	2	29106072
Pubmed	Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo.	ISL2 ISL1	6.13e-05	6	71	2	9272948
Pubmed	Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression.	ISL2 ISL1	6.13e-05	6	71	2	32083082
Pubmed	Pax6 influences the time and site of origin of glial precursors in the ventral neural tube.	ISL2 ISL1	6.13e-05	6	71	2	9828088
Pubmed	Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis.	ISL2 ISL1	6.13e-05	6	71	2	28892058
Pubmed	Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns.	ISL2 ISL1	6.13e-05	6	71	2	20345923
Pubmed	Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord.	ISL2 ISL1	6.13e-05	6	71	2	11312598
Pubmed	Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.	COPB1 COPG1	6.13e-05	6	71	2	11884415
Pubmed	Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.	COPB1 COPG1	6.13e-05	6	71	2	8858162
Pubmed	The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog.	ISL2 ISL1	6.13e-05	6	71	2	10677261
Pubmed	Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.	ISL2 ISL1	6.13e-05	6	71	2	18842897
Pubmed	Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord.	ISL2 ISL1	6.13e-05	6	71	2	16145668
Pubmed	RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth.	ISL2 ISL1	6.13e-05	6	71	2	31811168
Pubmed	Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.	ISL1 NOS1	6.13e-05	6	71	2	22351125
Pubmed	Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points.	ISL2 ISL1	6.13e-05	6	71	2	12575949
Pubmed	Differential expression of LIM-homeodomain genes in the embryonic murine brain.	ISL1 LHX8	6.13e-05	6	71	2	8817562
Pubmed	Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina.	ISL2 ISL1	6.13e-05	6	71	2	12040030
Pubmed	Activation of Six1 Expression in Vertebrate Sensory Neurons.	ISL2 ISL1	6.13e-05	6	71	2	26313368
Pubmed	The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex.	COPB1 COPG1	6.13e-05	6	71	2	14527956
Pubmed	Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.	ISL2 ISL1	6.13e-05	6	71	2	21900566
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	COPG1 AMOTL1 BTAF1 TARBP1	6.28e-05	104	71	4	31240132
Pubmed	Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.	ISL2 ISL1 NOS1	6.53e-05	38	71	3	25936505
Pubmed	Zic2 patterns binocular vision by specifying the uncrossed retinal projection.	ISL2 ISL1	8.57e-05	7	71	2	13678579
GeneFamily	LIM class homeoboxes	ISL2 ISL1 LHX8	3.56e-06	12	47	3	522
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF555 ZNF532 ZNF549 ZFHX2 ZNF740 ZBTB12 BCL6 PRDM15	4.74e-04	718	47	8	28
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	FAM184A PPP2R3A OPTN CNOT6L N4BP2 RABGAP1L ESRRG OTUD4 ZFHX2 OCRL FRMPD3 TARBP1 STRIP1	7.47e-06	1106	71	13	M39071
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#2_top-relative-expression-ranked_1000	CNOT6L NETO2 AMOTL1 ISL2 ISL1 BCL6 LHX8 PCYT1B	3.35e-08	150	70	8	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000_k2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184A MARCHF10 ESRRG HECTD1 NOS1	6.11e-06	162	71	5	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MIS18BP1 LMO1 TBC1D2 KCNAB2 NUF2	8.18e-06	172	71	5	dd9ba79e1542fe9fa2c319077d83dd3fc0158f46
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184A MARCHF10 ESRRG HECTD1 NOS1	1.08e-05	182	71	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
Drug	Benzathine benzylpenicillin [5928-84-7]; Up 200; 4.2uM; MCF7; HT_HG-U133A	LIG3 OPTN PDE6B RABGAP1L TBC1D2 NOS1 UAP1L1	2.54e-06	195	71	7	7359_UP
Disease	REM sleep behavior disorder	OCRL INPP5F	8.27e-05	6	70	2	EFO_0007462
Disease	B-cell lymphoma (is_implicated_in)	BTK BCL6	1.16e-04	7	70	2	DOID:707 (is_implicated_in)
Disease	Disorder of eye	FRAS1 NPHP3 PDE6B CEP290 MTTP	1.51e-04	212	70	5	C0015397
Disease	Meckel-Gruber syndrome	NPHP3 CEP290	2.47e-04	10	70	2	cv:C0265215
Disease	Renal dysplasia and retinal aplasia (disorder)	NPHP3 CEP290	3.61e-04	12	70	2	C0403553
Disease	glutarylcarnitine (C5-DC) measurement	ISL2 GCDH	7.37e-04	17	70	2	EFO_0800030
Disease	Meckel syndrome type 1	NPHP3 CEP290	8.28e-04	18	70	2	C3714506
Disease	mean fractional anisotropy measurement	GAL3ST1 WDFY3 ZZEF1	1.51e-03	95	70	3	EFO_0008399
Disease	Fever	PTGES NOS1	1.87e-03	27	70	2	C0015967
Disease	blood manganese measurement	OCRL INPP5F	1.87e-03	27	70	2	EFO_0007581
Disease	azoospermia (implicated_via_orthology)	ESRRG ZNF622	1.87e-03	27	70	2	DOID:14227 (implicated_via_orthology)
Disease	L-arginine measurement	HBS1L GCDH	1.87e-03	27	70	2	EFO_0006524
Disease	C-X-C motif chemokine 10 measurement	FRAS1 ARHGEF28 CNOT6L	2.24e-03	109	70	3	EFO_0008056

Protein segments in the cluster

Peptide	Gene	Start	Entry
FGYARERLEEMHVLC	EOGT	121	Q5NDL2
CEAMEYLESKQFLHR	BTK	506	Q06187
EEKRAVPDRMCRHNY	HLA-DPB1	96	P04440
RRCQDMEYTIKNLHA	AMOTL1	746	Q8IY63
AYKHRVEDMQLCAEA	FAM184A	131	Q8NB25
LMKDSRYQHFFEACR	ARHGEF9	211	O43307
HKCQMDRSREQYARD	GMEB2	301	Q9UKD1
MACIHYLRENREKFE	OTUD4	66	Q01804
FDQARLYSCLDHMRE	HBS1L	76	Q9Y450
VMRARDNVYHLDCFA	LMO1	101	P25800
HFFYSMKERRQESCA	ARHGEF28	906	Q8N1W1
DDAEYMKHTRLFRCS	FLII	1156	Q13045
HFPRYAVMKERCSEA	FRAS1	3201	Q86XX4
VTKDFRRVENAYHME	IRAK1BP1	111	Q5VVH5
RRVENAYHMEAEVCI	IRAK1BP1	116	Q5VVH5
RNDCDKYVFRMQKYH	MIS18BP1	1051	Q6P0N0
VMNEAERYEALRHCR	PCYT1B	126	Q9Y5K3
YCARIFKQHFMDSRI	RHOT1	506	Q8IXI2
NFIHFREACRETYME	NUF2	126	Q9BZD4
VLKEMVAHNYDRFSR	MTTP	596	P55157
DIAQDMVLYHVKCDR	PDE6B	446	P35913
HEMILVCDAYRKDLQ	COPB1	96	P53618
CRVHYDCMLDNLKRE	LHX8	186	Q68G74
CEMAEQRFCVDYAKR	LIG3	86	P49916
DLKRCRMAHIFYDTF	PPP2R3A	1041	Q06190
ICEQAEYHMFQREKV	KCNAB2	211	Q13303
EDLHCKFYQLERLMQ	RABGAP1L	661	Q5R372
ESFIKHMENEYRCRG	NOS1	661	P29475
NIICNHMRFHYDEVR	GAL3ST1	136	Q99999
RVALRHMERCYAKYE	CXXC1	496	Q9P0U4
QKVRTMARDLYDDHF	HECTD1	831	Q9ULT8
HRAQEYARSKLAECM	BTAF1	1311	O14981
EFCLHTARQYALDRM	GCDH	306	Q92947
ELNERQRAEHCQKMY	CEP290	1066	O15078
FCYLHMREQRKEQES	FRMPD3	561	Q5JV73
YEEELLCRMSNKDRH	ESRRG	16	P62508
YLQMEHVVDTCRKFI	BCL6	111	P41182
MQHKVDSEYQACLRR	MARCHF10	21	Q8NA82
RCEALSQRHMIYEES	MAP7D3	571	Q8IWC1
AMEYDEKLARFRQAH	DEF8	61	Q6ZN54
ESCLRNKHEMVVYEA	COPG1	256	Q9Y678
MDIYCHRFVQDAQNK	INPP5F	956	Q9Y2H2
AFCRYADEMKEIQER	PURB	271	Q96QR8
LVMRARDSVYHIECF	ISL2	101	Q96A47
AQMEVYCSDFHAERA	OPTN	466	Q96CV9
CLHMFLQEEAIDRNY	SNX12	141	Q9UMY4
KYQAMERAATFEHDR	NPHP3	151	Q7Z494
EHMRVHDNVREYLCA	PRDM15	1101	P57071
MNRKCFEEDFRIHVT	STRIP1	96	Q5VSL9
LRFLDYQMEHSNECK	NETO2	221	Q8NC67
FVMRARSKVYHIECF	ISL1	91	P61371
ERCLRAHRNDMETIY	PTGES	66	O14684
DAIGYCLTFEHRERM	PPP1R15B	681	Q5SWA1
RNQDYKDICARMSFV	OCRL	386	Q01968
NHKDFKELRYNECLM	CNOT6L	431	Q96LI5
AEVFIMDNKRCDRHY	PRSS45P	141	Q7RTY3
DCLFMQRDVYISHVR	ZNF532	1031	Q9HCE3
AASYLQMEHVVEKCR	ZBTB12	106	Q9Y330
CFREHVRMHPEDKSY	ZNF555	466	Q8NEP9
EAQRCLYHDVMLENF	ZNF549	46	Q6P9A3
EEGEKIQHMYRCARV	WDFY3	2531	Q8IZQ1
DVTHRYLCRQCKMAF	ZFHX2	2446	Q9C0A1
DMERRGVEFVHVYCV	UAP1L1	241	Q3KQV9
KVCRLVNEVYHMYNR	PMS2	301	P54278
EQADIARMLYKDTCH	ZMYND11	236	Q15326
MHMFIARYCDLLNVD	ZZEF1	1766	O43149
VAFRDADMQRAHYKT	ZNF622	11	Q969S3
MENTKREDHYVRICA	TARBP1	1106	Q13395
CDICDMRFIQKYHLE	ZNF740	131	Q8NDX6
YHNVKCRREMFDKDV	UBR2	681	Q8IWV8
HLKDDMEAYRTQNCF	TBC1D2	456	Q9BYX2
DYRAEAFLHQQKRME	N4BP2	1621	Q86UW6