Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	spectrin binding	PTPRC GBP1 GBP3	1.83e-04	34	65	3	GO:0030507
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARHGEF12 GBP1 GBP3 EPS8L3 ARHGAP21 DENND4C TBC1D17 IQGAP1	2.32e-04	507	65	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ARHGEF12 GBP1 GBP3 EPS8L3 ARHGAP21 DENND4C TBC1D17 IQGAP1	2.32e-04	507	65	8	GO:0030695
GeneOntologyMolecularFunction	lipopolysaccharide binding	GBP1 GBP3 NLRP6	5.13e-04	48	65	3	GO:0001530
GeneOntologyMolecularFunction	GDP phosphatase activity	GBP1 GBP3	6.74e-04	12	65	2	GO:0004382
GeneOntologyMolecularFunction	Hsp90 protein binding	GBP1 GBP3 PPEF2	7.65e-04	55	65	3	GO:0051879
GeneOntologyMolecularFunction	cytoskeletal protein binding	PTPRC MYO1A CEP290 GBP1 GBP3 EPS8L3 NEB TUBGCP5 CAP2 HSP90AA1 IQGAP1	7.73e-04	1099	65	11	GO:0008092
GeneOntologyMolecularFunction	actin binding	MYO1A GBP1 GBP3 EPS8L3 NEB CAP2 IQGAP1	9.17e-04	479	65	7	GO:0003779
GeneOntologyMolecularFunction	microtubule minus-end binding	CEP290 TUBGCP5	1.07e-03	15	65	2	GO:0051011
GeneOntologyBiologicalProcess	inflammasome-mediated signaling pathway	USP50 GBP1 GBP3 NLRP6	2.49e-05	53	66	4	GO:0141084
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	MYO1A CCDC42 CARMIL1 CEP290 CILK1 EPS8L3 CDC14A TBC1D17 HSP90AA1 KIAA0753	5.00e-05	670	66	10	GO:0120031
GeneOntologyBiologicalProcess	cell projection assembly	MYO1A CCDC42 CARMIL1 CEP290 CILK1 EPS8L3 CDC14A TBC1D17 HSP90AA1 KIAA0753	6.01e-05	685	66	10	GO:0030031
GeneOntologyBiologicalProcess	positive regulation of AIM2 inflammasome complex assembly	GBP1 GBP3	6.03e-05	4	66	2	GO:0140973
GeneOntologyBiologicalProcess	positive regulation of inflammasome-mediated signaling pathway	USP50 GBP1 GBP3	7.72e-05	26	66	3	GO:0141087
GeneOntologyBiologicalProcess	regulation of AIM2 inflammasome complex assembly	GBP1 GBP3	1.50e-04	6	66	2	GO:0140971
GeneOntologyCellularComponent	host cell part	GBP1 GBP3	1.60e-04	6	69	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP1 GBP3	1.60e-04	6	69	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP1 GBP3	1.60e-04	6	69	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP1 GBP3	1.60e-04	6	69	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP1 GBP3	1.60e-04	6	69	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP1 GBP3	1.60e-04	6	69	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP1 GBP3	1.60e-04	6	69	2	GO:0030430
GeneOntologyCellularComponent	symbiont cell surface	GBP1 GBP3	2.97e-04	8	69	2	GO:0106139
GeneOntologyCellularComponent	other organism part	GBP1 GBP3	3.81e-04	9	69	2	GO:0044217
GeneOntologyCellularComponent	microtubule organizing center	USP50 CUL3 CCDC42 CEP290 ASPM CILK1 TUBGCP5 CDC14A PTPN20 KIAA0753	8.29e-04	919	69	10	GO:0005815
GeneOntologyCellularComponent	centrosome	USP50 CUL3 CCDC42 CEP290 ASPM TUBGCP5 CDC14A PTPN20 KIAA0753	9.34e-04	770	69	9	GO:0005813
GeneOntologyCellularComponent	host cellular component	GBP1 GBP3	1.10e-03	15	69	2	GO:0018995
Domain	IQ	MYO1A ASPM PPEF2 IQGAP1	1.23e-04	71	67	4	PF00612
Domain	IQ	MYO1A ASPM PPEF2 IQGAP1	2.04e-04	81	67	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYO1A ASPM PPEF2 IQGAP1	3.06e-04	90	67	4	IPR000048
Domain	IQ	MYO1A ASPM PPEF2 IQGAP1	3.47e-04	93	67	4	PS50096
Domain	PTPase_domain	PTPRC CDC14A PTPN20	4.27e-04	41	67	3	IPR000242
Domain	Y_phosphatase	PTPRC CDC14A PTPN20	4.27e-04	41	67	3	PF00102
Domain	GBP_C	GBP1 GBP3	5.60e-04	10	67	2	PF02841
Domain	G_GB1_RHD3_dom	GBP1 GBP3	6.83e-04	11	67	2	IPR030386
Domain	Guanylate-bd_C	GBP1 GBP3	6.83e-04	11	67	2	IPR003191
Domain	GBP	GBP1 GBP3	6.83e-04	11	67	2	PF02263
Domain	Guanylate-bd_N	GBP1 GBP3	6.83e-04	11	67	2	IPR015894
Domain	G_GB1_RHD3	GBP1 GBP3	6.83e-04	11	67	2	PS51715
Domain	PTPc_motif	PTPRC CDC14A PTPN20	1.24e-03	59	67	3	SM00404
Domain	Tyr_Pase_cat	PTPRC CDC14A PTPN20	1.24e-03	59	67	3	IPR003595
Domain	Myosin-like_IQ_dom	ASPM IQGAP1	2.08e-03	19	67	2	IPR027401
Domain	-	ASPM IQGAP1	2.08e-03	19	67	2	4.10.270.10
Domain	Tyr_Pase_AS	PTPRC CDC14A PTPN20	2.29e-03	73	67	3	IPR016130
Domain	P-loop_NTPase	TTF2 MYO1A ASPM GBP1 HS3ST5 GBP3 SLFN14 IQGAP1 NLRP6	3.16e-03	848	67	9	IPR027417
Domain	TYR_PHOSPHATASE_1	PTPRC CDC14A PTPN20	3.65e-03	86	67	3	PS00383
Domain	TYR_PHOSPHATASE_2	PTPRC CDC14A PTPN20	3.77e-03	87	67	3	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPRC CDC14A PTPN20	3.77e-03	87	67	3	IPR000387
Domain	-	PTPRC CDC14A PTPN20	4.41e-03	92	67	3	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	PTPRC CDC14A PTPN20	5.41e-03	99	67	3	IPR029021
Pubmed	Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.	PTPRC GBP1 HSP90AA1	1.22e-06	11	69	3	24337748
Pubmed	Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.	APOB HSP90AA1	3.88e-06	2	69	2	11333259
Pubmed	Analysis of WDFY4 rs7097397 and PHLDB1 rs7389 polymorphisms in Chinese patients with systemic lupus erythematosus.	PHLDB1 WDFY4	3.88e-06	2	69	2	35188604
Pubmed	The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1.	GBP1 GBP3	3.88e-06	2	69	2	7518790
Pubmed	Developmental regulation of apolipoprotein B mRNA editing is an autonomous function of small intestine involving homeobox gene Cdx1.	CDX1 APOB	3.88e-06	2	69	2	12493769
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP290 CILK1 KCNS2 GPAM TUBGCP5 WDFY4 ANO8 KIAA0753	6.04e-06	493	69	8	15368895
Pubmed	Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.	GBP1 GBP3	1.16e-05	3	69	2	30062052
Pubmed	Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.	GBP1 GBP3	1.16e-05	3	69	2	26416908
Pubmed	Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.	GBP1 GBP3	1.16e-05	3	69	2	32354743
Pubmed	GTPase properties of the interferon-induced human guanylate-binding protein 2.	GBP1 GBP3	1.16e-05	3	69	2	8706832
Pubmed	Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.	GBP1 GBP3	1.16e-05	3	69	2	32620042
Pubmed	[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].	GBP1 GBP3	1.16e-05	3	69	2	29089068
Pubmed	Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.	GBP1 GBP3	1.16e-05	3	69	2	23248289
Pubmed	Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.	GBP1 GBP3	1.16e-05	3	69	2	1715024
Pubmed	Two families of GTPases dominate the complex cellular response to IFN-gamma.	GBP1 GBP3	1.16e-05	3	69	2	9862701
Pubmed	The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.	GBP1 GBP3	1.16e-05	3	69	2	11726669
Pubmed	GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.	GBP1 GBP3	1.16e-05	3	69	2	38636926
Pubmed	Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.	GBP1 GBP3	1.16e-05	3	69	2	36639389
Pubmed	The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.	GBP1 GBP3	1.16e-05	3	69	2	16914101
Pubmed	The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.	GBP1 GBP3	1.16e-05	3	69	2	22730319
Pubmed	Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.	GBP1 GBP3	1.16e-05	3	69	2	15717119
Pubmed	Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.	GBP1 GBP3	1.16e-05	3	69	2	35383115
Pubmed	Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.	GBP1 GBP3	1.16e-05	3	69	2	20950129
Pubmed	Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.	GBP1 GBP3	2.32e-05	4	69	2	7823961
Pubmed	Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.	GBP1 GBP3	2.32e-05	4	69	2	36609599
Pubmed	Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions.	PTPRC APOB	2.32e-05	4	69	2	22144566
Pubmed	Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.	GBP1 GBP3	2.32e-05	4	69	2	10386861
Pubmed	Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.	GBP1 GBP3	2.32e-05	4	69	2	38404575
Pubmed	cDNA for the beta 1 subunit of guanyl nucleotide-binding regulatory proteins from mouse adrenal glands.	GBP1 GBP3	2.32e-05	4	69	2	8917111
Pubmed	The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.	GBP1 GBP3	2.32e-05	4	69	2	39337476
Pubmed	PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth.	CUL3 ARHGEF12	3.86e-05	5	69	2	21670212
Pubmed	A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.	CUL3 HSP90AA1	3.86e-05	5	69	2	35088844
Pubmed	TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.	GBP1 GBP3	3.86e-05	5	69	2	30858199
Pubmed	Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.	GBP1 GBP3	3.86e-05	5	69	2	12396730
Pubmed	Unique features of different members of the human guanylate-binding protein family.	GBP1 GBP3	3.86e-05	5	69	2	17266443
Pubmed	CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells.	PTPRC CBLB	3.86e-05	5	69	2	27841348
Pubmed	A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.	USP50 HSP90AA1	3.86e-05	5	69	2	20930503
Pubmed	Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis.	NBAS TENM4	3.86e-05	5	69	2	23991058
Pubmed	Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.	GBP1 GBP3	3.86e-05	5	69	2	21151871
Pubmed	Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.	CUL3 HSP90AA1	3.86e-05	5	69	2	24608665
Pubmed	Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.	GBP1 GBP3	3.86e-05	5	69	2	31964735
Pubmed	Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.	GBP1 GBP3	3.86e-05	5	69	2	9858320
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CUL3 USP53 TTF2 CARMIL1 CEP290 CILK1 ARHGAP21 HSP90AA1 IQGAP1	4.68e-05	853	69	9	28718761
Pubmed	Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.	GBP1 GBP3	5.79e-05	6	69	2	17293456
Pubmed	Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.	GBP1 GBP3	5.79e-05	6	69	2	21757726
Pubmed	The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase.	GBP1 GBP3	8.09e-05	7	69	2	20505078
Pubmed	TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.	GBP1 GBP3	8.09e-05	7	69	2	30587103
Pubmed	The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.	GBP1 GBP3	8.09e-05	7	69	2	21502320
Pubmed	CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression.	KLHL38 CUL3	1.08e-04	8	69	2	33977871
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP1 GBP3	1.08e-04	8	69	2	16689661
Pubmed	Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.	GBP1 GBP3	1.38e-04	9	69	2	24739961
Pubmed	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.	GBP1 GBP3	1.38e-04	9	69	2	33479228
Pubmed	Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3.	CUL3 HSP90AA1	1.38e-04	9	69	2	24844779
Pubmed	Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.	PTPRC CBLB	1.73e-04	10	69	2	16503409
Pubmed	Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.	GBP1 GBP3	1.73e-04	10	69	2	28334111
Pubmed	Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.	CDX1 PTPRC APOB	1.82e-04	55	69	3	10926756
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	UQCRC1 CPS1 HSP90AA1 IQGAP1	1.98e-04	144	69	4	35681168
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CEP290 TUBGCP5 CDC14A KIAA0753	2.08e-04	146	69	4	21399614
Pubmed	Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.	GBP1 GBP3	2.11e-04	11	69	2	24715728
Pubmed	IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.	GBP1 GBP3	2.11e-04	11	69	2	27693356
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP1 GBP3	2.11e-04	11	69	2	18025219
Pubmed	Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.	PTPRC CBLB	2.11e-04	11	69	2	29562201
Pubmed	Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.	GBP1 GBP3	2.53e-04	12	69	2	35906252
Pubmed	LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.	GBP1 GBP3	2.53e-04	12	69	2	29459437
Pubmed	FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.	PTPRC CPS1	2.98e-04	13	69	2	9107685
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	CEP290 TUBGCP5 HSP90AA1	3.13e-04	66	69	3	12221128
Pubmed	TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.	CEP290 DENND4C HSP90AA1	3.27e-04	67	69	3	34644545
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	GBP1 GBP3	4.01e-04	15	69	2	17114464
Pubmed	Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.	GBP1 GBP3	4.01e-04	15	69	2	25774716
Pubmed	A human MAP kinase interactome.	USP53 CEP290 NEB CBLB CAP2 HSP90AA1	4.11e-04	486	69	6	20936779
Pubmed	CAND1 enhances deneddylation of CUL1 by COP9 signalosome.	CUL3 HSP90AA1	4.57e-04	16	69	2	16036220
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	NEB IQGAP1	4.57e-04	16	69	2	24960163
Pubmed	The Genetic Basis of Baculum Size and Shape Variation in Mice.	PTPRC ASPM	4.57e-04	16	69	2	26935419
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TTF2 CARMIL1 ARHGEF12 ARHGAP21 DENND4C HSP90AA1 IQGAP1	5.08e-04	708	69	7	39231216
Pubmed	The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.	GBP1 GBP3	5.18e-04	17	69	2	25774715
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	GPAM APOB	5.18e-04	17	69	2	17496333
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	PHLDB1 CARMIL1 ARHGEF12 HSP90AA1	5.33e-04	187	69	4	26460568
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	CARMIL1 SLFN14 NLRP6	5.71e-04	81	69	3	22139419
Pubmed	The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.	GBP1 GBP3	5.81e-04	18	69	2	27001747
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	TENM4 SAMD3	5.81e-04	18	69	2	20602751
Pubmed	Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.	PTPRC HSP90AA1	5.81e-04	18	69	2	12519789
Pubmed	A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.	GBP1 GBP3	6.49e-04	19	69	2	21551061
Pubmed	MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.	UQCRC1 NEB	7.20e-04	20	69	2	15967462
Pubmed	Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.	GBP1 GBP3	7.20e-04	20	69	2	32150572
Pubmed	UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes.	CBLB HSP90AA1	7.20e-04	20	69	2	31659016
Pubmed	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.	HSP90AA1 IQGAP1	7.20e-04	20	69	2	22504172
Pubmed	CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.	CUL3 HSP90AA1	7.95e-04	21	69	2	12481031
Pubmed	An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.	GBP1 GBP3	7.95e-04	21	69	2	19158679
Pubmed	Discovery and refinement of loci associated with lipid levels.	PHLDB1 GPAM APOB CPS1	8.36e-04	211	69	4	24097068
Pubmed	Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.	SLC17A5 APOB	8.73e-04	22	69	2	17983586
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	KLHL38 USP53 PHLDB1 CARMIL1 APOB ARHGAP21	9.36e-04	569	69	6	30639242
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP50 USP53	9.55e-04	23	69	2	14715245
Pubmed	Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.	UQCRC1 HSP90AA1	1.04e-03	24	69	2	19110265
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GPAM WDFY4 ANO8	1.08e-03	101	69	3	10997877
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPRC CEP290 PPEF2 CDC14A PTPN20 CAP2 HSP90AA1 KIAA0753	1.10e-03	1049	69	8	27880917
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	ASPM CDC14A HSP90AA1	1.11e-03	102	69	3	20508983
Pubmed	Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.	GBP1 GBP3	1.13e-03	25	69	2	35139355
Pubmed	Functional proteomics mapping of a human signaling pathway.	TTF2 PTPRC PPIL4 CILK1 CBLB CAP2	1.14e-03	591	69	6	15231748
Pubmed	The human (PEDB) and mouse (mPEDB) Prostate Expression Databases.	NEB MTERF4 IQGAP1	1.25e-03	106	69	3	11752298
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	PHLDB1 CARMIL1 CBLB	1.31e-03	108	69	3	19531213
Interaction	CALM2 interactions	CUL3 CEP290 ASPM ARHGEF12 PPEF2 WDFY4 DENND4C IQGAP1	4.55e-07	206	68	8	int:CALM2
Interaction	TRIM36 interactions	CUL3 CEP290 ASPM CDC14A ARHGAP21 HSP90AA1 KIAA0753	5.53e-07	144	68	7	int:TRIM36
Interaction	CALM3 interactions	CUL3 CEP290 ASPM ARHGEF12 PPEF2 ARHGAP21 DENND4C IQGAP1	1.97e-05	343	68	8	int:CALM3
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A APOB EPS8L3 NLRP6	3.30e-06	147	69	5	a5ed71afe5fcb4f541080f5552252695c7d4d090
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A APOB EPS8L3 NLRP6	3.53e-06	149	69	5	7726957b1de638c3bfc659381d15eab626bb179b
ToppCell	droplet-Fat-Mat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A APOB EPS8L3 NLRP6	4.42e-06	156	69	5	cfd7f56f3155db677684827607e9008e975dbe70
ToppCell	droplet-Fat-Mat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A APOB EPS8L3 NLRP6	4.42e-06	156	69	5	0d79b4172896574b00faf00e87254f68d76f5512
ToppCell	droplet-Fat-Mat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A APOB EPS8L3 NLRP6	4.42e-06	156	69	5	f09150aacb6121f913648ed3918f9cd4f22c61f2
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRC EPS8L3 PPEF2 WDFY4 IQGAP1	5.00e-06	160	69	5	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-NK_bright-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MMRN1 PCDHGA5 EPS8L3 SAMD3 CBLB	9.10e-06	181	69	5	4795833e0ec49287bd7809ecfe523fc527565fba
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-NK_bright\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MMRN1 PCDHGA5 EPS8L3 SAMD3 CBLB	9.10e-06	181	69	5	208cdccc2f0d0f2d8ec321064c63aed206d46c32
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 MYO1A APOB EPS8L3 PPP1R16A	1.40e-05	198	69	5	e3e2233c796d5e9051c8c1b66f70f406f048ed56
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 MYO1A APOB CPS1 PPP1R16A	1.40e-05	198	69	5	7696f042648bd53c0a019dfeea68808aa5898615
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 MYO1A APOB EPS8L3 CPS1	1.40e-05	198	69	5	ecdef1a0a0b8399e193b922c8ca8c25e63de4a4f
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 MYO1A APOB CPS1 PPP1R16A	1.40e-05	198	69	5	e67488695ce5e32ed8d149ed0b841540cbfdd3e2
ToppCell	3'-Child09-12-SmallIntestine-Epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 MYO1A APOB EPS8L3 PPP1R16A	1.44e-05	199	69	5	043c65bdf54a1bf0e483fea9ffc042ff5b271764
ToppCell	3'-Child04-06-SmallIntestine-Epithelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 MYO1A APOB EPS8L3 PPP1R16A	1.44e-05	199	69	5	ab71b312635a2b2c98d71b60a299f44bc80a3587
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX1 APOB EPS8L3 CPS1 PPP1R16A	1.44e-05	199	69	5	914f66e2b4af323d09fa2340a39cf8051d00a422
ToppCell	control-MAIT\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD3 CBLB CDC14A CAP2 HSP90AA1	1.47e-05	200	69	5	aeea4bda2e38cc6db571ed2b47ce022d637619bd
ToppCell	367C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	EFCAB12 ZNF808 APOB ANO8	1.58e-05	97	69	4	a1279377bf0ee5662db8b9303f5f1fd418dee6df
ToppCell	367C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	EFCAB12 ZNF808 APOB ANO8	1.58e-05	97	69	4	12cbd03b33e76e5e471bbee2a9c11f27e8b21123
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP53 TTF2 EFCAB12 MTERF4	4.01e-05	123	69	4	511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCell	368C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	AP4S1 HEATR4 CEP290 ANO8	8.45e-05	149	69	4	f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCell	368C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	AP4S1 HEATR4 CEP290 ANO8	8.45e-05	149	69	4	9286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Ebf1_(Anterior_pretectal_nucleus_(APT))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	HEATR4 APOB NLRP6	9.52e-05	57	69	3	ef44602342511a9f90c93463628ad8b154cb26fb
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Ebf1_(Anterior_pretectal_nucleus_(APT))\|Thalamus / BrainAtlas - Mouse McCarroll V32	HEATR4 APOB NLRP6	9.52e-05	57	69	3	a3dc14f7a63cc70b2789770644e0b9453426c6f9
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM4 PTPRC WDFY4 IQGAP1	1.03e-04	157	69	4	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Dcn\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MMRN1 APOB FAM187A	1.06e-04	59	69	3	ebc80c32b56e97c3ab3ac5ae00f06f7f2bcc3d39
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Dcn-Excitatory_Neuron.Slc17a7.Dcn-Camk2d_(CA1_Principal_cells)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MMRN1 APOB FAM187A	1.06e-04	59	69	3	719728ed089762ae79cbfbe56c4171d70361a772
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Dcn-Excitatory_Neuron.Slc17a7.Dcn-Camk2d_(CA1_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MMRN1 APOB FAM187A	1.06e-04	59	69	3	55954d610f5a813ef15ab5e898c5ad309fc9e319
ToppCell	facs-SCAT-Fat-18m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A EPS8L3 NLRP6	1.17e-04	162	69	4	341fa357ad7bdbef30864e8062f161e60185ffc9
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MMRN1 SAMD3 CBLB NLRP6	1.17e-04	162	69	4	9b1c07f0af657095379380c39d763cab0ad73e74
ToppCell	facs-SCAT-Fat-18m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A EPS8L3 NLRP6	1.17e-04	162	69	4	7215f6eb2b65dea455e2eec722a9c38e6958b120
ToppCell	facs-SCAT-Fat-18m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A EPS8L3 NLRP6	1.17e-04	162	69	4	7fa93efa2039d68a4e8214fa143bcd3368349a2d
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASPM CILK1 SLFN14 AWAT2	1.19e-04	163	69	4	7864e966c228282b4b63c43164dba3faba21026d
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRC CCDC42 SAMD3 HSP90AA1	1.31e-04	167	69	4	d80b64322d16d98c82a52724809740b9de208f39
ToppCell	Adult-Immune-natural_killer_cell-D122\|Adult / Lineage, Cell type, age group and donor	PTPRC SAMD3 CBLB NLRP6	1.31e-04	167	69	4	ff1ce3b1a2d91d2ad979f25899db4f4eeb865892
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TENM4 MYO1A WDFY4 PTPN20	1.34e-04	168	69	4	d60f7cd8269f373827f49c7785002cb38e4570a9
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TENM4 MYO1A WDFY4 PTPN20	1.37e-04	169	69	4	ccd98f9005aa0a88bd49f153be4e7200cc3dd0ac
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRC SAMD3 CBLB IQGAP1	1.40e-04	170	69	4	9a47d03f7eea6299a836a0eb1e7c1252c03f76df
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRC SAMD3 CBLB IQGAP1	1.40e-04	170	69	4	4252c0a335762508bd1f8f71c6e78a657d7df125
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CARMIL1 GBP1 GBP3 CPS1	1.40e-04	170	69	4	07b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRC SAMD3 CBLB IQGAP1	1.40e-04	170	69	4	0aa11d8cb44403b6769860dac2d3b05da6fff79d
ToppCell	ileum\|World / shred on tissue and cell subclass	MYO1A APOB EPS8L3 PPP1R16A	1.40e-04	170	69	4	9f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	PTPRC APOB CBLB CDC14A	1.44e-04	171	69	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPRC EPS8L3 WDFY4 IQGAP1	1.47e-04	172	69	4	584af6537685cb459bf0fc298e6f46872016c116
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL38 PTPRC MYO1A WDFY4	1.47e-04	172	69	4	f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	EPS8L3 CPS1 NEB	1.47e-04	66	69	3	d6b202d9f5bebaac23b34b689ad306549dec0593
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	EPS8L3 CPS1 NEB	1.47e-04	66	69	3	4a714cf035b22da103054098f85f9170c56e9e83
ToppCell	facs-GAT-Fat-24m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A EPS8L3 KIAA0753	1.50e-04	173	69	4	815ba48a9222ea09ba8005e2d2f7c5addf118ad1
ToppCell	facs-GAT-Fat-24m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A EPS8L3 KIAA0753	1.50e-04	173	69	4	98e464d9e6d6b69421e9e4041b638b6825247f60
ToppCell	facs-GAT-Fat-24m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 MYO1A EPS8L3 KIAA0753	1.50e-04	173	69	4	3e6f0a08eddfd61871f7a85acccf6d539af6ebda
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRC CCDC42 ASPM SAMD3	1.68e-04	178	69	4	c4a2e9a440e941e82bb35abefa054e07ad250d45
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-MAIT_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRC SAMD3 CBLB CLEC4C	1.68e-04	178	69	4	f52f837e948deb6a2d031325f49891bca8d375da
ToppCell	facs-Heart-LV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 PTPRC CLCF1 NLRP6	1.79e-04	181	69	4	57f82f54e20e19aa17a2ea22af22e3bc8965d622
ToppCell	facs-Heart-LV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 PTPRC CLCF1 NLRP6	1.79e-04	181	69	4	8855812c85ef45c1be6bd511619b2dfe5e441264
ToppCell	RA-17._Lymphocyte\|RA / Chamber and Cluster_Paper	PTPRC SAMD3 CDC14A NLRP6	1.82e-04	182	69	4	257a7847917b6ea1d60608183d90300bfd028758
ToppCell	facs-Heart-LV-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 PTPRC CLCF1 NLRP6	1.82e-04	182	69	4	d0d18dd5d8b2d21e42c3c4259f824c91f24a54bc
ToppCell	facs\|World / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP53 CDX1 EPS8L3 IQGAP1	1.82e-04	182	69	4	08f775135b451be709f5fc8e1cbcf63425794a2e
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PTPRC SAMD3 CBLB HSP90AA1	1.86e-04	183	69	4	79defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCell	Control-APC-like-Dendritic_cells\|Control / group, cell type (main and fine annotations)	TENM4 PTPRC WDFY4 CLEC4C	1.86e-04	183	69	4	8f9c8e2436f18ea7c265b08e4e149e19cb513a16
ToppCell	Control-APC-like\|Control / group, cell type (main and fine annotations)	TENM4 PTPRC WDFY4 CLEC4C	1.86e-04	183	69	4	c313ac72cc9fa1583456d452393f61f0a4ca33a8
ToppCell	RA-17._Lymphocyte\|World / Chamber and Cluster_Paper	PTPRC SAMD3 CDC14A NLRP6	1.86e-04	183	69	4	6397f684a50346fc42cccb5afbe10350f4b2d9b0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM4 APOB CPS1 NEB	1.90e-04	184	69	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM4 APOB CPS1 NEB	1.90e-04	184	69	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM4 APOB CPS1 NEB	1.90e-04	184	69	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	TTF2 NBAS PTPRC CBLB	1.94e-04	185	69	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-CD4_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PTPRC GBP1 SAMD3 NLRP6	1.94e-04	185	69	4	32f43ddc8a899827924834546db33928e353271b
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-MAIT_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRC SAMD3 CBLB CDC14A	1.94e-04	185	69	4	8314dc608bc837df3037e89afd9db39737374ebc
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRC SAMD3 CBLB IQGAP1	1.98e-04	186	69	4	71e87c4c755ab607689cb050f5a363cb520a0f53
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	TTF2 NBAS PTPRC CBLB	1.98e-04	186	69	4	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	ILEUM-inflamed-(1)_CD8_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CUL3 PTPRC CBLB CDC14A	2.02e-04	187	69	4	a77d7ae44f47410bd92fb3aa0f44dce891752b63
ToppCell	Control-T_cells\|Control / group, cell type (main and fine annotations)	PTPRC SAMD3 CBLB CDC14A	2.02e-04	187	69	4	f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|368C / Donor, Lineage, Cell class and subclass (all cells)	TTF2 AP4S1 ZER1 SAMD3	2.06e-04	188	69	4	ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMK+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PTPRC SAMD3 CBLB HSP90AA1	2.06e-04	188	69	4	2513ca0efa73c09a3406b99e2876982d78b173d7
ToppCell	3'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP53 SWT1 ZER1 TBC1D17	2.11e-04	189	69	4	7dad62bd50c197838058e89abd0ee387de3e83cd
ToppCell	Control-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.11e-04	189	69	4	ee4c1d930534788a7759d92dc8ff9c62e6ee2301
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo\|lymph-node_spleen / Manually curated celltypes from each tissue	PTPRC ASPM SAMD3 CBLB	2.15e-04	190	69	4	4225bfa10a6fb909a3ba8ac26f3541c390b46737
ToppCell	COPD-Lymphoid-T_Cytotoxic\|Lymphoid / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.15e-04	190	69	4	10bece40d980d37a01dae8ce887655bf9f93040c
ToppCell	IPF-Lymphoid-T_Cytotoxic\|IPF / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.15e-04	190	69	4	e5d0186bfb416a3eda76ac12b9379650afb6f409
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	PTPRC SAMD3 CBLB CDC14A	2.15e-04	190	69	4	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	USP53 PHLDB1 CARMIL1 CBLB	2.15e-04	190	69	4	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	ASK428-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	PTPRC ZNF808 SAMD3 MTERF4	2.15e-04	190	69	4	d649f7e17c4227787465dfc02037f791ff85378b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRC SAMD3 CBLB CDC14A	2.19e-04	191	69	4	d9506b88d806aadd4c2b9bf86fe994c47799e7f6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRC SAMD3 CBLB CDC14A	2.19e-04	191	69	4	b42c54308abe1241cc38ddce96b9d38d07983891
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	NBAS PTPRC CBLB IQGAP1	2.19e-04	191	69	4	9454f642c3621370fa23640b631301346b300950
ToppCell	Control-Lymphoid-T_Cytotoxic\|Control / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.19e-04	191	69	4	03b5c5e0941c3402ab3f48cbf3da2a027d110421
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	USP53 PHLDB1 CARMIL1 CBLB	2.19e-04	191	69	4	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PTPRC SAMD3 CBLB HSP90AA1	2.19e-04	191	69	4	2ad34ccd55362db04511c90cf264ae5b93b48dde
ToppCell	COVID-19-T_cells-CD4+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPRC SAMD3 CBLB CDC14A	2.19e-04	191	69	4	0646cca78e24aeb6baa9934d3c439b797c567997
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRC SAMD3 CBLB CDC14A	2.19e-04	191	69	4	9aabbc65430e2233b8f2d3fff9face7807b88b48
ToppCell	COVID-19-T_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPRC SAMD3 CBLB CDC14A	2.19e-04	191	69	4	7f64add931b64b8d35836fa6bee9ebab593844d3
ToppCell	COPD-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.24e-04	192	69	4	5bfd9f5d47511441eb2d3cc3c4d7ed330ffd0bd1
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4/8-lo\|lymph-node_spleen / Manually curated celltypes from each tissue	PTPRC ASPM SAMD3 CBLB	2.24e-04	192	69	4	4d72b9264ed62e0c08cde4078061b348253f6989
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PTPRC SAMD3 CBLB HSP90AA1	2.24e-04	192	69	4	7460ce6e2f91bbf940b684f63231db7501ace09f
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMK+\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PTPRC SAMD3 CBLB HSP90AA1	2.24e-04	192	69	4	71bc03b08cda0382ea45b503d5f4f135ed98cc11
ToppCell	COPD-Lymphoid\|COPD / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.24e-04	192	69	4	064fefb8212fadab0ff441f4bf643559b7fdb25d
ToppCell	COPD-Lymphoid-T_Cytotoxic\|COPD / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.28e-04	193	69	4	58e94fe2e89cdafc6974938f97a4c162061a437d
ToppCell	IPF-Lymphoid-T_Cytotoxic\|Lymphoid / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.28e-04	193	69	4	3c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCell	IPF-Lymphoid\|IPF / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.28e-04	193	69	4	bf9d50aea909a28dd1d0933af33842d5f1ae7818
ToppCell	IPF-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	PTPRC SAMD3 CBLB CDC14A	2.28e-04	193	69	4	35c902a983d7f1156a74fe68ee366609029833b3
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PTPRC COA1 SAMD3 CBLB	2.28e-04	193	69	4	a594f89a18273797506287d9e22f72abe53e4920
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPRC SAMD3 CBLB CDC14A	2.28e-04	193	69	4	b9769b45125d2244afe53f9f71c92c04ddccf980
Disease	obsolete_red blood cell distribution width	CUL3 AP4S1 MYO1A PCDHGA5 CARMIL1 APOB CPS1 SLFN14 ARHGAP21 DENND4C IQGAP1	1.59e-04	1347	65	11	EFO_0005192
Disease	melanoma	CUL3 SLC17A5 SLC39A12 HS3ST5 GPAM	2.21e-04	248	65	5	C0025202
Disease	platelet crit	PTPRC HEATR4 CARMIL1 ARHGEF12 GPAM APOB UQCRC1 CPS1 SLFN14	2.31e-04	952	65	9	EFO_0007985
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	GPAM APOB CPS1	4.42e-04	67	65	3	EFO_0008595, EFO_0020946
Disease	mean corpuscular hemoglobin concentration	PTPRC PCDHGA5 CARMIL1 COA1 CPS1 NEB ARHGAP21 PPP1R16A NLRP6	6.81e-04	1105	65	9	EFO_0004528
Disease	amino acid measurement	MMRN1 NBAS TENM4 CCDC42 CARMIL1 CPS1 TUBGCP5	7.19e-04	678	65	7	EFO_0005134
Disease	vitamin D measurement	CARMIL1 ZNF808 GPAM APOB CPS1	8.78e-04	336	65	5	EFO_0004631
Disease	liver fibrosis measurement	CARMIL1 APOB NLRP6	9.16e-04	86	65	3	EFO_0010576
Disease	nephrotic syndrome (biomarker_via_orthology)	GPAM APOB	1.28e-03	24	65	2	DOID:1184 (biomarker_via_orthology)
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	ZER1 GPAM APOB	1.38e-03	99	65	3	EFO_0004611, EFO_0007878
Disease	Acute kidney injury	GBP1 GBP3	1.39e-03	25	65	2	HP_0001919
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	ZER1 GPAM APOB	1.50e-03	102	65	3	EFO_0004329, EFO_0004611
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	GPAM APOB CPS1	1.54e-03	103	65	3	EFO_0008595, EFO_0020944
Disease	stimulant use measurement	NBAS CPS1	1.74e-03	28	65	2	EFO_0600076

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSLIYRNALLHKSYK	nan	46	A8MVM7
DITYTLEYSRLKNKH	CATSPERG	891	Q6ZRH7
KEFHYSRYITIRRKS	CDX1	171	P47902
LKSYSLSRKKIVHYT	CDC14A	71	Q9UNH5
DKDRQHLYRTQYLKG	FAM187A	301	A6NFU0
RLEHQRLSAKLKDYY	CCDC42	136	Q96M95
YSYLHSRKIKILEIF	EFCAB12	191	Q6NXP0
ENKLYKRTALALHYL	ASPM	3246	Q8IZT6
YSDLYKHTNSKETRR	ARHGEF12	406	Q9NZN5
NYRLESAYEKHLIIK	ANO8	426	Q9HCE9
QKKAYQDRLAYLRSH	IQGAP1	791	P46940
KSVDNYYHLLTTRDL	PCDHGA5	396	Q9Y5G8
SHKSKYQTDLYERER	PPIL4	456	Q8WUA2
LSKYYEHVDINKRTL	AP4S1	16	Q9Y587
SSYRHDEKRNIYQKI	KCNMB2	11	Q9Y691
KNYRKYFRSEAALTL	MYO1A	761	Q9UBC5
HSRSILYYESLNKTL	MMRN1	496	Q13201
KALFLYTSHLRKYND	DDX58	536	O95786
YTSHLRKYNDALIIS	DDX58	541	O95786
TYQHLRLILSKYDDN	CBLB	81	Q13191
YTNRVLKDYKHSDLR	CAP2	166	P40123
YKAVRTSIYTKHLER	HS3ST5	226	Q8IZT8
SRAIYLHRKEYSQNL	EPS8L3	6	Q8TE67
SVNLRDYYAHKVKSL	KCNS2	441	Q9ULS6
QLYYVTELTHRIRSK	GBP1	141	P32455
QLYYVTELTHRIRSK	GBP3	141	Q9H0R5
KDLDQLIKIHYRYLS	TUBGCP5	921	Q96RT8
KYSHLYDLSRSEKEK	NBAS	1986	A2RRP1
REHTAYYIKALSKDL	UQCRC1	126	P31930
DSFIKYIRYARKSHL	PTPN20	331	Q4JDL3
KDATRFKHLRKYTYN	APOB	41	P04114
RKVDSKSLFHYRQYS	CPS1	1481	P31327
AKYHTLYIDALRKLF	AWAT2	301	Q6E213
RHQQSLLYKEYLSEK	CEP290	816	O15078
YYKQHLARRLLTNKS	CUL3	431	Q13618
FSSQYRLHRKSQYLK	HEATR4	51	Q86WZ0
KSRDRAYAKFYTLLS	DENND4C	606	Q5VZ89
KIENYLLRNHETRKY	CARMIL1	656	Q5VZK9
RKKLSELLRYYTSAS	HSP90AA1	456	P07900
KRISHYEKEYILSSL	SLC17A5	256	Q9NRA2
SNKEYKFYLHSLLSL	SLC39A12	136	Q504Y0
LIQKFHSRALYYKLA	COA1	36	Q9GZY4
TLLSVSEYKKKYREH	NLRP6	111	P59044
LHARYVLNLLYETKK	PPEF2	141	O14830
SRAIKHLYLLYEKRA	SLFN14	896	P0C7P3
RTDIYKKTRHILESY	SAMD3	351	Q8N6K7
SEYLQYSLTKIKQRH	MTERF4	251	Q7Z6M4
YSLTKIKQRHIYLER	MTERF4	256	Q7Z6M4
YLQKLHKYLITRTER	GPAM	751	Q9HCL2
RHLYSKRLDRSVSYQ	PPP1R16A	421	Q96I34
AIRIEKLKHSYNESY	KIAA0753	56	Q2KHM9
KSDHTDVLYYNIKRR	SWT1	56	Q5T5J6
LRSAAKQHYLKHSRY	CILK1	481	Q9UPZ9
TVKRLSKLREYQQYH	CLEC4C	51	Q8WTT0
QKTYDLTRYLEHQLR	CLCF1	41	Q9UBD9
TDTYRLKYHQRPKLS	USP53	1046	Q70EK8
YLHTSAKKYQDRDSL	TBC1D17	16	Q9HA65
YNLIYRSTRHLKRLA	TMEM192	126	Q8IY95
LDISRDRLSSYYKFK	ZER1	251	Q7Z7L7
YHSRVLRLQAAIKYS	TTC30B	111	Q8N4P2
VNTLRRYKRHYKLQT	SAP30L	116	Q9HAJ7
ELYASLYKDHVQRRK	WDFY4	2236	Q6ZS81
LVYHRRLHTLEKSYK	ZNF808	526	Q8N4W9
KIYDDHRKFTLRILY	TENM4	1851	Q6N022
ELHEALKKYHYSRRR	USP50	146	Q70EL3
DRLKRTLSYYVDKHE	PHLDB1	1281	Q86UU1
YHSRVLRLQAAIKYS	TTC30A	111	Q86WT1
RYKQSLKYHLRTHTG	ZNF777	816	Q9ULD5
RGHSLYLYKDKREQT	ARHGAP21	966	Q5T5U3
LRHSKRKDSRTVYQY	PTPRC	1106	P08575
EKRVNSNKLRVYLYH	TTF2	661	Q9UNY4
SYYSKHLKRHLREKR	ZNF337	726	Q9Y3M9
KLNTDLYHTKRSLRY	GOLGA8CP	136	A6NN73
RLYKASAITLHRSIY	KLHL38	321	Q2WGJ6
TSERLYRELYHKLKD	NEB	5016	P20929