Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	2.72e-10	1244	33	15	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	3.67e-10	1271	33	15	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	1.58e-09	1412	33	15	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	2.48e-09	1459	33	15	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF93 ZNF131 SP2 ZNF721 ZNF148 FEZF2 ZNF281	7.59e-07	320	33	7	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF93 ZNF131 SP2 ZNF721 ZNF148 FEZF2 ZNF281	8.60e-07	326	33	7	GO:0001217
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	GFI1B ZNF131 PLAG1 ZNF721 FEZF2 PRDM15	2.75e-04	560	33	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	GFI1B ZNF131 PLAG1 ZNF721 FEZF2 PRDM15	2.91e-04	566	33	6	GO:0001216
GeneOntologyMolecularFunction	protein kinase A regulatory subunit binding	AKAP8L RYR2	7.76e-04	25	33	2	GO:0034237
GeneOntologyMolecularFunction	lipid kinase activity	DGKB IPMK	2.09e-03	41	33	2	GO:0001727
GeneOntologyMolecularFunction	protein kinase A binding	AKAP8L RYR2	4.13e-03	58	33	2	GO:0051018
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	ZNF675 GFI1B ZNF93 ZNF131 SP2 ZNF721 ZNF148 FEZF2 ZNF281	2.20e-05	1053	32	9	GO:0000122
Domain	Znf_C2H2-like	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 AKAP8L ZNF655	3.24e-14	796	32	16	IPR015880
Domain	Znf_C2H2	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 AKAP8L ZNF655	3.86e-14	805	32	16	IPR007087
Domain	ZnF_C2H2	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 AKAP8L ZNF655	4.09e-14	808	32	16	SM00355
Domain	-	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	7.01e-14	679	32	15	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	9.63e-14	694	32	15	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	4.77e-13	775	32	15	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	4.95e-13	777	32	15	PS00028
Domain	zf-C2H2	ZNF675 GFI1B ZNF93 ZNF131 SP2 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	2.09e-12	693	32	14	PF00096
Domain	zf-C2H2_6	ZNF675 GFI1B ZNF93 ZNF721 ZNF860 ZNF117 FEZF2	8.33e-07	314	32	7	PF13912
Domain	C2H2_Znf_fam	ZNF131 PLAG1	7.67e-04	24	32	2	IPR027775
Domain	SPRY	TRIM50 RYR2	9.72e-03	87	32	2	SM00449
Domain	SPRY	TRIM50 RYR2	1.13e-02	94	32	2	PF00622
Domain	SPRY_dom	TRIM50 RYR2	1.13e-02	94	32	2	IPR003877
Domain	B30.2/SPRY	TRIM50 RYR2	1.15e-02	95	32	2	IPR001870
Domain	B302_SPRY	TRIM50 RYR2	1.15e-02	95	32	2	PS50188
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF131 ZNF138 ZNF148	5.24e-07	17	33	3	7557990
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF721 ZNF148 ZNF655	6.81e-07	808	33	8	20412781
Pubmed	Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2 functions.	ZNF148 ZNF281	8.73e-07	2	33	2	37948511
Pubmed	Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.	PPP1R9B RYR2	8.73e-07	2	33	2	24812280
Pubmed	Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain.	LRRC4C FEZF2	5.23e-06	4	33	2	32348754
Pubmed	Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development.	ZNF148 ZNF281	5.23e-06	4	33	2	31455666
Pubmed	ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1.	ZNF148 ZNF281	8.72e-06	5	33	2	12771217
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	ZNF281 AKAP8L ZNF655 SUPT16H	2.36e-05	177	33	4	26206133
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF93 ZNF117	2.44e-05	8	33	2	2023909
Pubmed	Genome-wide and candidate gene association study of cigarette smoking behaviors.	ZNF93 ZNF138	6.77e-05	13	33	2	19247474
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	ZNF281 ZNF655 SUPT16H	8.93e-05	91	33	3	34780483
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF93 ZNF721	9.10e-05	15	33	2	15885501
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	SP2 ZNF148 ZNF281 SUPT16H	2.36e-04	321	33	4	32098917
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	PPP1R9B ZNF148 ZNF281	2.45e-04	128	33	3	23858473
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF131 ZNF148 ZNF281 PRDM15 SUPT16H	2.54e-04	608	33	5	36089195
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	ZNF148 ZNF281 ESRP1 SUPT16H	2.97e-04	341	33	4	32971831
Pubmed	Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.	PRDM15 RYR2	3.25e-04	28	33	2	23006423
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF131 ZNF148 ZNF281 AKAP8L	3.31e-04	351	33	4	38297188
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF93 ZNF721	3.49e-04	29	33	2	14563677
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	ZNF131 ZNF281 AKAP8L RFWD3	6.00e-04	411	33	4	35182466
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	ZNF131 ZNF148 PRDM15	6.42e-04	178	33	3	27637333
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF93 ZNF721 ZNF655	6.74e-04	181	33	3	37372979
Pubmed	The DNA sequence of human chromosome 7.	DGKB TRIM50 TAS2R5 ZNF655	7.80e-04	441	33	4	12853948
Pubmed	EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.	ZNF148 ZNF281	8.06e-04	44	33	2	27505670
Pubmed	Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.	MAPKAP1 ZNF148	8.43e-04	45	33	2	22926577
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF93 PPP1R9B ZNF138 AKAP8L	8.48e-04	451	33	4	36168627
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	ZNF138 TRIM50 ZNF117	9.74e-04	271	33	3	chr7q11
Cytoband	7q11.21	ZNF138 ZNF117	1.64e-03	83	33	2	7q11.21
Cytoband	19p12	ZNF675 ZNF93	1.93e-03	90	33	2	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF675 ZNF93	3.50e-03	122	33	2	chr19p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF675 GFI1B ZNF93 ZNF131 SP2 PLAG1 ZNF138 ZNF721 ZNF860 ZNF117 ZNF148 FEZF2 ZNF281 PRDM15 ZNF655	1.93e-14	718	28	15	28
Coexpression	MIKKELSEN_IPS_ICP_WITH_H3K27ME3	GFI1B LRRC4C ESRP1	4.56e-05	55	33	3	M1970
Coexpression	MIKKELSEN_IPS_ICP_WITH_H3K27ME3	GFI1B LRRC4C ESRP1	4.56e-05	55	33	3	MM842
Drug	Moxonidine [75438-57-2]; Down 200; 16.6uM; MCF7; HT_HG-U133A	ZNF93 ZNF131 ATP11A AKAP8L TBC1D17 RYR2	3.76e-07	199	33	6	7343_DN
Drug	vinylene	ZNF93 PLAG1 ZNF148 FEZF2 PRDM15 AKAP8L	1.27e-06	245	33	6	CID000006326
Disease	carnosine measurement	ZNF675 LRRC4C	2.37e-04	24	28	2	EFO_0010470
Disease	testicular carcinoma	ZNF675 RFWD3	6.62e-04	40	28	2	EFO_0005088
Disease	suntan	ATP11A PRDM15	4.30e-03	103	28	2	EFO_0004279
Disease	smoking status measurement	MAPKAP1 ZNF131 LRRC4C ZNF655 RYR2	4.30e-03	1160	28	5	EFO_0006527
Disease	Myopia	LRRC4C RYR2 RFWD3	5.67e-03	385	28	3	HP_0000545
Disease	immature platelet measurement	GFI1B PPP1R9B	5.69e-03	119	28	2	EFO_0803541
Disease	severe acute respiratory syndrome, COVID-19	DGKB ATP11A LRRC4C	8.54e-03	447	28	3	EFO_0000694, MONDO_0100096
Disease	PR interval	DGKB LRRC4C RYR2	1.13e-02	495	28	3	EFO_0004462
Disease	COVID-19, mortality	DGKB LRRC4C	1.13e-02	170	28	2	EFO_0004352, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRHTFYHGHKKRMAL	C2orf16	961	Q68DN1
SHLDSKFHKEHFKYV	AKAP8L	406	Q9ULX6
HMIQKTRKRKYFHHD	CLK1	401	P49759
HKHHMGTRYIEVYKA	ESRP1	286	Q6NXG1
QHKHKYHFQKTFTVS	RFWD3	431	Q6PCD5
RFHQKSDMKKHTYIH	GFI1B	256	Q5VTD9
KHVAYIIRSHMKDHY	LCN1P1	101	Q5VSP4
IFYKMRKQHHRQNHH	LRRC4C	546	Q9HCJ2
KMYARHRKIYTKKHH	IPMK	316	Q8NFU5
HHHLRKKDKDFSSMR	IL36B	141	Q9NZH7
KTYVKSKRNTDVMHH	DGKB	296	Q9Y6T7
RDFHKAMESHKHYTQ	RYR2	4046	Q92736
VYNLTFHMHTHNDKK	FEZF2	401	Q8TBJ5
ALRHHMKLHKGIKEY	PRDM15	1126	P57071
HHYKSFKVSMIHRLR	MAPKAP1	381	Q9BPZ7
HFHLKNAIMFGKKRH	SUPT16H	721	Q9Y5B9
FKHLKKMLLVHGHFY	ATP11A	861	P98196
YCEKMFHRKDHLKNH	PLAG1	96	Q6DJT9
YTHHKKMKVHSAGRR	TAS2R5	196	Q9NYW4
HKAHIRKKTDEYFRM	TBC1D17	336	Q9HA65
LSRHEFIHMGKKHYK	ZNF93	356	P35789
KYVKVMHKFSNSNRH	ZNF138	86	P52744
KKKAHLHHYLQVEGM	TUBE1	421	Q9UJT0
QKRFMRSDHLTKHYK	SP2	591	Q02086
KAFMHSSHLNKHEKI	ZNF721	216	Q8TF20
FIQKYHMERHKRTHS	ZNF281	326	Q9Y2X9
FSHSDRHKIKHMENK	ZNF675	156	Q8TD23
HHKMHRKEKSYECNE	ZNF655	426	Q8N720
SNRHKMRHTENKHFK	ZNF117	96	Q03924
YAKQRRIHMGEKHHK	ZNF860	581	A6NHJ4
KLFYHFKEHMKSHST	ZNF131	271	P52739
FIQKYHMERHKRTHS	ZNF148	236	Q9UQR1
DHHKFIRKFHSMASR	TRIM50	236	Q86XT4
HHKKYGSNVHRIKSM	PPP1R9B	46	Q96SB3