Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidate cytidylyltransferase activity

CDS1 CDS2

1.17e-053402GO:0004605
GeneOntologyMolecularFunctioncytidylyltransferase activity

CDS1 CDS2

1.74e-0410402GO:0070567
GeneOntologyMolecularFunctionphosphatidate phosphatase activity

LPIN1 LPIN2

3.51e-0414402GO:0008195
GeneOntologyMolecularFunctionlipid phosphatase activity

LPIN1 LPIN2

6.55e-0419402GO:0042577
GeneOntologyBiologicalProcessglycerolipid biosynthetic process

LPIN1 CDS1 CWH43 CDS2 DGAT2L6 LPIN2

1.21e-05268406GO:0045017
GeneOntologyBiologicalProcesslipid biosynthetic process

LPIN1 CERK CDS1 CWH43 PDSS1 CDS2 DGAT2L6 LPIN2

1.41e-04813408GO:0008610
GeneOntologyBiologicalProcessphototransduction

CDS1 PLEKHB1 CDS2

1.48e-0453403GO:0007602
GeneOntologyBiologicalProcessglycerolipid metabolic process

LPIN1 CDS1 CWH43 CDS2 DGAT2L6 LPIN2

1.65e-04429406GO:0046486
GeneOntologyBiologicalProcessneutral lipid biosynthetic process

LPIN1 DGAT2L6 LPIN2

2.48e-0463403GO:0046460
GeneOntologyBiologicalProcessacylglycerol biosynthetic process

LPIN1 DGAT2L6 LPIN2

2.48e-0463403GO:0046463
GeneOntologyBiologicalProcessCDP-diacylglycerol biosynthetic process

CDS1 CDS2

2.82e-0413402GO:0016024
GeneOntologyBiologicalProcessactin filament depolymerization

MICAL2 CAPZA1 CAPZA2

2.84e-0466403GO:0030042
GeneOntologyBiologicalProcessCDP-diacylglycerol metabolic process

CDS1 CDS2

3.29e-0414402GO:0046341
GeneOntologyBiologicalProcesslipid droplet formation

CDS1 CDS2

3.79e-0415402GO:0140042
GeneOntologyBiologicalProcessdetection of light stimulus

CDS1 PLEKHB1 CDS2

4.47e-0477403GO:0009583
GeneOntologyCellularComponentF-actin capping protein complex

CAPZA1 CAPZA2

1.34e-049412GO:0008290
GeneOntologyCellularComponentbrush border

ACE2 SLC26A6 CAPZA1 CAPZA2

2.21e-04152414GO:0005903
GeneOntologyCellularComponentendoplasmic reticulum membrane

LPIN1 CDS1 ABCC12 ZDHHC1 MAN1B1 CDS2 DGAT2L6 LPIN2 RNF26

7.45e-041293419GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

LPIN1 CDS1 ABCC12 ZDHHC1 MAN1B1 CDS2 DGAT2L6 LPIN2 RNF26

7.71e-041299419GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

LPIN1 CDS1 ABCC12 ZDHHC1 MAN1B1 CDS2 DGAT2L6 LPIN2 RNF26

8.98e-041327419GO:0042175
GeneOntologyCellularComponentcluster of actin-based cell projections

ACE2 SLC26A6 CAPZA1 CAPZA2

9.37e-04223414GO:0098862
DomainPC_trans

CDS1 CDS2

4.47e-062402IPR000374
DomainCDS

CDS1 CDS2

4.47e-062402PS01315
DomainPC_Trfase_euk

CDS1 CDS2

4.47e-062402IPR016720
DomainLipin_N

LPIN1 LPIN2

1.34e-053402IPR007651
DomainLipin_mid

LPIN1 LPIN2

1.34e-053402PF16876
DomainF-actin_cap_A

CAPZA1 CAPZA2

1.34e-053402PF01267
DomainCapZ_alpha

CAPZA1 CAPZA2

1.34e-053402IPR002189
DomainLipin_mid

LPIN1 LPIN2

1.34e-053402IPR031703
DomainF-actin_cap_asu_CS

CAPZA1 CAPZA2

1.34e-053402IPR017865
DomainF_ACTIN_CAPPING_A_1

CAPZA1 CAPZA2

1.34e-053402PS00748
DomainF_ACTIN_CAPPING_A_2

CAPZA1 CAPZA2

1.34e-053402PS00749
DomainLipin_N

LPIN1 LPIN2

1.34e-053402PF04571
DomainLNS2

LPIN1 LPIN2

6.67e-056402PF08235
DomainLNS2

LPIN1 LPIN2

6.67e-056402IPR013209
DomainLNS2

LPIN1 LPIN2

6.67e-056402SM00775
DomainLNS2/PITP

LPIN1 LPIN2

6.67e-056402IPR031315
DomainGPCR_2-like

FZD7 VIPR1

7.32e-0360402IPR017981
DomainGPCR_2_secretin-like

FZD7 VIPR1

7.32e-0360402IPR000832
DomainG_PROTEIN_RECEP_F2_4

FZD7 VIPR1

7.56e-0361402PS50261
Domain-

LPIN1 LPIN2

8.29e-03644023.40.50.1000
DomainHAD-like_dom

LPIN1 LPIN2

1.24e-0279402IPR023214
PathwayREACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS

LPIN1 CDS1 CDS2 DGAT2L6 LPIN2

2.86e-06120275MM14585
PathwayREACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS

LPIN1 CDS1 CDS2 DGAT2L6 LPIN2

3.92e-06128275M706
PathwayWP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PATHWAY

LPIN1 CDS2 LPIN2

2.46e-0530273M39592
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

LPIN1 CDS1 CDS2 DGAT2L6 LPIN2

3.11e-05196275MM14591
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

LPIN1 CDS1 CDS2 DGAT2L6 LPIN2

4.42e-05211275M649
PathwayREACTOME_SYNTHESIS_OF_PE

LPIN1 LPIN2

2.30e-0412272MM14586
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

LPIN1 LPIN2

2.30e-0412272MM15447
PathwayREACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA

LPIN1 LPIN2

2.30e-0412272MM15105
PathwayREACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING

CAPZA1 CAPZA2

2.72e-0413272M975
PathwayREACTOME_SYNTHESIS_OF_PE

LPIN1 LPIN2

2.72e-0413272M656
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

LPIN1 LPIN2

3.17e-0414272M619
PathwayREACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA

LPIN1 LPIN2

3.65e-0415272M27360
PathwayWP_CONGENITAL_GENERALIZED_LIPODYSTROPHY

LPIN1 LPIN2

5.30e-0418272M42546
PathwayWP_ETHER_LIPID_BIOSYNTHESIS

LPIN1 LPIN2

6.57e-0420272M46451
PathwayREACTOME_TRIGLYCERIDE_METABOLISM

LPIN1 LPIN2

8.72e-0423272MM15575
PathwayREACTOME_METABOLISM_OF_LIPIDS

LPIN1 CERK CDS1 CDS2 DGAT2L6 LPIN2

9.47e-04620276MM15193
PathwayREACTOME_SYNTHESIS_OF_PC

LPIN1 LPIN2

1.12e-0326272MM14584
PathwayREACTOME_SYNTHESIS_OF_PC

LPIN1 LPIN2

1.29e-0328272M684
Pubmed

CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms.

CDS1 CDS2

1.42e-06242231548309
Pubmed

A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.

LPIN1 LPIN2

1.42e-06242219717560
Pubmed

Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.

CDS1 CDS2

1.42e-0624229806839
Pubmed

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.

CDS1 CDS2

1.42e-06242226946540
Pubmed

Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.

CDS1 CDS2

1.42e-06242216023307
Pubmed

Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.

LPIN1 LPIN2

1.42e-06242224133206
Pubmed

Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle.

LPIN1 LPIN2

1.42e-06242231752156
Pubmed

Distinct properties of the two isoforms of CDP-diacylglycerol synthase.

CDS1 CDS2

1.42e-06242225375833
Pubmed

The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities.

LPIN1 LPIN2

1.42e-0624222722772
Pubmed

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.

LPIN1 LPIN2

1.42e-06242229534981
Pubmed

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

LPIN1 LPIN2

1.42e-06242222908270
Pubmed

Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

CAPZA1 CAPZA2

4.27e-0634229331217
Pubmed

Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.

LPIN1 LPIN2

4.27e-06342210884287
Pubmed

Lipin-1 and lipin-3 together determine adiposity in vivo.

LPIN1 LPIN2

4.27e-06342224634820
Pubmed

Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.

LPIN1 LPIN2

4.27e-06342218694939
Pubmed

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.

LPIN1 LPIN2

4.27e-06342230507612
Pubmed

Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.

LPIN1 LPIN2

4.27e-06342233596934
Pubmed

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.

LPIN1 LPIN2

4.27e-06342217158099
Pubmed

Lipin proteins form homo- and hetero-oligomers.

LPIN1 LPIN2

4.27e-06342220735359
Pubmed

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.

LPIN1 LPIN2

4.27e-06342222481384
Pubmed

Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.

CAPZA1 CAPZA2

4.27e-06342212470955
Pubmed

Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.

LPIN1 LPIN2

4.27e-06342221857965
Pubmed

Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.

CAPZA1 CAPZA2

4.27e-06342234796874
Pubmed

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.

LPIN1 LPIN2

8.53e-06442211138012
Pubmed

Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.

CAPZA1 CAPZA2

8.53e-0644227665558
Pubmed

The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.

CDS1 CDS2

8.53e-0644229407135
Pubmed

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.

CAPZA1 CAPZA2

8.53e-06442230361697
Pubmed

Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.

LPIN1 LPIN2

8.53e-06442219136718
Pubmed

Mammalian CARMIL inhibits actin filament capping by capping protein.

CAPZA1 CAPZA2

8.53e-06442216054028
Pubmed

Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.

CDS1 CDS2

2.98e-0574229889000
Pubmed

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

CPAMD8 PRG3 SANBR

7.77e-056842322412388
Pubmed

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

CAPZA1 CAPZA2

7.78e-051142215850461
Pubmed

Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes.

CAPZA1 CAPZA2

7.78e-05114229119363
Pubmed

Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.

FZD7 TRPV6

1.10e-041342222266179
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

LPIN1 ACE2 PAPLN MAP7D1 YTHDF2 MAN1B1

1.23e-0465042638777146
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

CERK ABCC12 DNLZ TIMMDC1 PDSS1 PDHX BAD

2.36e-04104742718614015
Pubmed

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.

CAPZA1 CAPZA2

2.67e-042042218723693
Pubmed

TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.

TIMMDC1 PDSS1 BAD

3.41e-0411242324344204
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

VIPR1 CPAMD8 CDS1 MICAL2 MAN1B1 LMLN BAD CAPZA1

3.56e-04148942828611215
Pubmed

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.

CAPZA1 CAPZA2

3.86e-042442221822214
Pubmed

Biosynthesis of triacylglycerols.

LPIN1 LPIN2

5.28e-04284228944226
Pubmed

RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.

DNMT3A CAPZA1 CAPZA2

7.38e-0414642321589869
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

CERK ABCC12 TIMMDC1 PDSS1 PDHX BAD

8.11e-0492642620877624
Pubmed

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.

CDS1 MAN1B1

8.74e-043642238070861
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

TAOK2 ACE2 PAPLN PRG3 TIMMDC1 MAN1B1

1.12e-0398542612975309
Pubmed

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.

CAPZA1 CAPZA2

1.13e-034142224614889
GeneFamilyLipins

LPIN1 LPIN2

5.50e-0632521043
CoexpressionGSE6681_DELETED_FOXP3_VS_WT_TREG_DN

PDSS1 LMLN DNMT3A LPIN2 RNF26

1.47e-05200415M6779
DrugPhenelzine sulfate [156-51-4]; Down 200; 17uM; MCF7; HT_HG-U133A

TAOK2 FZD7 LPIN1 VIPR1 PLEKHB1 RUSF1

1.28e-061954164360_DN
Drugwortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A

FZD7 LPIN1 SFI1 PLEKHB1 DNMT3A

2.20e-051894157002_UP
Drugtroglitazone; Up 200; 10uM; MCF7; HT_HG-U133A

LPIN1 VIPR1 PLEKHB1 MICAL2 RUSF1

2.43e-051934156949_UP
DrugMetformin hydrochloride [1115-70-4]; Up 200; 24.2uM; PC3; HT_HG-U133A

TAOK2 FZD7 LPIN1 DNMT3A LPIN2

2.43e-051934151816_UP
DrugOxyphenbutazone [129-20-4]; Down 200; 12.4uM; HL60; HT_HG-U133A

TRPV6 MICAL2 MAN1B1 CDS2 BAD

2.49e-051944156160_DN
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; HL60; HT_HG-U133A

FZD7 CDS1 SFI1 CDS2 BAD

2.75e-051984151300_UP
DrugFlurandrenolide [1524-88-5]; Down 200; 9.2uM; HL60; HT_HG-U133A

TAOK2 FZD7 CDS1 SFI1 BAD

2.75e-051984152184_DN
Diseasemyoglobinuria (implicated_via_orthology)

LPIN1 LPIN2

5.65e-063412DOID:0080108 (implicated_via_orthology)
DiseaseMental Retardation, Psychosocial

KANSL1 PDHX MAN1B1 DNMT3A

4.17e-05139414C0025363
DiseaseProfound Mental Retardation

KANSL1 PDHX MAN1B1 DNMT3A

4.17e-05139414C0020796
DiseaseMental deficiency

KANSL1 PDHX MAN1B1 DNMT3A

4.17e-05139414C0917816
Diseaselipid metabolism disorder (implicated_via_orthology)

LPIN1 LPIN2

1.96e-0415412DOID:3146 (implicated_via_orthology)
DiseaseIntellectual Disability

ACE2 KANSL1 PDHX MAN1B1 DNMT3A

3.73e-04447415C3714756
Diseasemiddle cerebral artery infarction (implicated_via_orthology)

BAD DNMT3A

1.80e-0345412DOID:3525 (implicated_via_orthology)
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

CAPZA1 CAPZA2

2.13e-0349412DOID:0060037 (implicated_via_orthology)
Diseasevisual perception measurement

CPAMD8 CDS2 LPIN2

3.67e-03223413EFO_0009700
Diseasemultiple sclerosis

CPAMD8 KANSL1 TIMMDC1 DNMT3A

9.13e-03594414MONDO_0005301

Protein segments in the cluster

PeptideGeneStartEntry
LSGLSSRWKNWWIRG

CDS1

76

Q92903
SRWKNWWIRGILTLT

CDS1

81

Q92903
WPGRIVSWWMTGRSR

DNMT3A

306

Q9Y6K1
SWTRVFQSWWDRNLG

BAD

146

Q92934
KNFWNGRWRSEWKFT

CAPZA1

166

P52907
DWRVRVWTGGAGSKW

AFDN-DT

81

Q9Y6Z5
NRALSNLSSRWKNWW

CDS2

56

O95674
NLSSRWKNWWVRGIL

CDS2

61

O95674
AVAWVWFQNRRAKWR

NOBOX

346

O60393
RSRWRWSGSVWVRSV

LMLN

26

Q96KR4
GALGWSVSRGANWRW

PDHX

31

O00330
ANWRWFHSTQWLRGD

PDHX

41

O00330
WKWAADRAAIVSRWN

KANSL1

436

Q7Z3B3
GRWWFSWRGRNTTIK

LPIN1

551

Q14693
DNSKSWRRRSCWRKW

MAN1B1

61

Q9UKM7
LRGWFLWKRFCWTDG

PRG3

166

Q9Y2Y8
FWIWSGKTLQSWRRF

FZD7

546

O75084
AWAWGWRRSSSEQGP

DNLZ

41

Q5SXM8
DWKPRWLRATWGSST

GJA9

416

P57773
MASRWWRWRRGCSWK

PDSS1

1

Q5T2R2
WRWRRGCSWKPAARS

PDSS1

6

Q5T2R2
RARRHRWKWAQVTFW

CERK

91

Q8TCT0
GGRRSAWVRNWTLWK

DGAT2L6

66

Q6ZPD8
SWDEFRTFWISWRGG

CPAMD8

1031

Q8IZJ3
RLWAWESWRSEVGKQ

ACE2

161

Q9BYF1
KTWAEIRQQRWSWAG

MAP7D1

221

Q3KQU3
NWRREFWWSLTPVNK

MICAL2

1246

O94851
WWSGSHLQRYLRIWG

CWH43

111

Q9H720
VGGWRWWGLSRAFTV

RUSF1

36

Q96GQ5
RVWWSTWRQRLGQVR

SFI1

221

A8K8P3
RWGSAPRTHQWRTWL

SLC26A6

46

Q9BXS9
AWRRVWSRSLQLASW

RNF26

286

Q9BY78
WVLCKGWNWRLARAS

TAOK2

1151

Q9UL54
KSWRDVYWRLWGTIN

SANBR

381

Q6NSI8
FSNWWLGLWLDKGSR

ABCC12

811

Q96J65
KNFWNGRWRSEWKFT

CAPZA2

166

P47755
WWKTRILWGVFLISR

SHANK2-AS3

51

Q9BTD1
RKWRRWHLQGVLGWN

VIPR1

401

P32241
KVRRQSDTWGPWSQW

PAPLN

21

O95428
GWLWRQSSILRRWKR

PLEKHB1

26

Q9UF11
RRWKRNWFALWLDGT

PLEKHB1

36

Q9UF11
AATRGFIRYGWRWGW

TIMMDC1

126

Q9NPL8
WRWGWRTAVFVTIFN

TIMMDC1

136

Q9NPL8
WSKFCRWFQRRESWA

TRPV6

56

Q9H1D0
WFWRWQKRHGISSQR

TIGD5

171

Q53EQ6
WSQDKWKGRFDVRWI

YTHDF2

486

Q9Y5A9
SPWTRFQWRRRAWAA

ZDHHC1

446

Q8WTX9
GRWWFWRKRESMTKQ

LPIN2

556

Q92539