Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SP6 HOXA4 GLIS3 FOXD2 FOXJ3 MNT ZNF652 CEBPA

1.82e-061244168GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SP6 HOXA4 GLIS3 FOXD2 FOXJ3 MNT ZNF652 CEBPA

2.14e-061271168GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SP6 HOXA4 GLIS3 FOXD2 FOXJ3 MNT ZNF652 CEBPA

4.72e-061412168GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SP6 HOXA4 GLIS3 FOXD2 FOXJ3 MNT ZNF652 CEBPA

6.03e-061459168GO:0000977
GeneOntologyMolecularFunctioncalcium channel regulator activity

STIM2 PDE4D

8.41e-0454162GO:0005246
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

GLIS3 FOXD2 FOXJ3 CEBPA

8.51e-04560164GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

GLIS3 FOXD2 FOXJ3 CEBPA

8.86e-04566164GO:0001216
GeneOntologyCellularComponentchromatin

SP6 HOXA4 FOXD2 FOXJ3 NCOR2 MNT CEBPA

5.69e-051480167GO:0000785
GeneOntologyCellularComponentpostsynaptic density, intracellular component

PRR7 IQSEC2

6.33e-0449162GO:0099092
GeneOntologyCellularComponentpostsynaptic specialization, intracellular component

PRR7 IQSEC2

8.26e-0456162GO:0099091
GeneOntologyCellularComponentnuclear matrix

NCOR2 CEBPA

5.03e-03140162GO:0016363
DomainTF_fork_head_CS_2

FOXD2 FOXJ3

8.85e-0446182IPR030456
DomainTF_fork_head_CS_1

FOXD2 FOXJ3

9.24e-0447182IPR018122
DomainFORK_HEAD_3

FOXD2 FOXJ3

1.00e-0349182PS50039
DomainFH

FOXD2 FOXJ3

1.00e-0349182SM00339
DomainFORK_HEAD_1

FOXD2 FOXJ3

1.00e-0349182PS00657
DomainFORK_HEAD_2

FOXD2 FOXJ3

1.00e-0349182PS00658
DomainForkhead

FOXD2 FOXJ3

1.00e-0349182PF00250
DomainFork_head_dom

FOXD2 FOXJ3

1.00e-0349182IPR001766
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

GLIS3 RNF38 FOXJ3 NCOR2 PRR7

3.76e-0643020535044719
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

FOXJ3 RBM33 NCOR2 MNT ZNF652 CEBPA

2.66e-05110320634189442
Pubmed

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

GLIS3 RNF38 NCOR2

3.37e-0511020337219487
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SP6 FOXD2 FOXJ3 MNT CEBPA

4.17e-0570920522988430
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

CCDC85C RBM33 NCOR2 MNT ZNF652 IQSEC2

4.32e-05120320629180619
Pubmed

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

HOXA4 NCOR2

6.55e-052120230254164
Pubmed

Role of β-catenin in development of bile ducts.

GLIS3 CEBPA

7.89e-052320226856660
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

FOXJ3 RBM33 NCOR2

8.83e-0515220338360978
Pubmed

Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.

MNT CEBPA

1.26e-042920218239623
Pubmed

A census of human transcription factors: function, expression and evolution.

SP6 HOXA4 FOXD2 FOXJ3 MNT

1.34e-0490820519274049
Pubmed

DNA-binding specificities of human transcription factors.

FOXD2 FOXJ3

1.45e-043120223332764
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

RBM33 NCOR2 STIM2

1.46e-0418020335198878
Pubmed

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.

SP6 NCOR2 CEBPA

1.74e-0419120324146773
Pubmed

Genome-wide atlas of gene expression in the adult mouse brain.

FOXD2 FOXJ3

4.42e-045420217151600
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

CCDC85C RBM33 STIM2

4.43e-0426320334702444
Pubmed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

FOXD2 FOXJ3

4.92e-045720221122108
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

RBM33 NCOR2 TMEM121B MNT ZNF652

5.16e-04121520515146197
Cytoband17q21.32

SP6 ZNF652

2.09e-044920217q21.32
Cytoband15q11.2

GOLGA6L6 GOLGA6L1

2.54e-0317220215q11.2
CytobandEnsembl 112 genes in cytogenetic band chr15q11

GOLGA6L6 GOLGA6L1

3.99e-03217202chr15q11
CytobandEnsembl 112 genes in cytogenetic band chr17q21

SP6 ZNF652

1.78e-02473202chr17q21
GeneFamilyForkhead boxes

FOXD2 FOXJ3

4.94e-0443142508
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

SP6 GLIS3 ZNF652

1.64e-0271814328
CoexpressionGSE39110_UNTREATED_VS_IL2_TREATED_CD8_TCELL_DAY6_POST_IMMUNIZATION_DN

SP6 GLIS3 STIM2 CEBPA

9.26e-06200184M9285
CoexpressionGSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_DN

FOXD2 RNF38 ZNF652 STIM2

9.26e-06200184M7353
CoexpressionGSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN

HOXA4 CCDC85C RBM33

1.52e-04154183M6824
CoexpressionGSE13485_CTRL_VS_DAY21_YF17D_VACCINE_PBMC_UP

RBM33 NCOR2 MNT

2.82e-04190183M3289
CoexpressionGSE22045_TREG_VS_TCONV_DN

FOXJ3 STIM2 PDE4D

2.87e-04191183M4401
CoexpressionGSE6259_33D1_POS_VS_DEC205_POS_SPLENIC_DC_UP

RBM33 MNT IQSEC2

2.96e-04193183M6730
CoexpressionGSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_MAC_DN

FOXJ3 NCOR2 IQSEC2

3.23e-04199183M5240
CoexpressionGSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_UP

NCOR2 MNT CEBPA

3.28e-04200183M6832
CoexpressionGSE26351_UNSTIM_VS_WNT_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_DN

GLIS3 RBM33 MNT

3.28e-04200183M8476
CoexpressionGSE360_HIGH_VS_LOW_DOSE_B_MALAYI_MAC_DN

NCOR2 MNT IQSEC2

3.28e-04200183M5262
CoexpressionGSE9988_LPS_VS_CTRL_TREATED_MONOCYTE_DN

RNF38 TMEM121B MNT

3.28e-04200183M5859
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_48H_ACT_TH1_UP

RNF38 FOXJ3 ZNF652

3.28e-04200183M4524
CoexpressionGSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_DN

RNF38 TMEM121B MNT

3.28e-04200183M5870
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

3.59e-05145203fd02d55755c35288a42ab08a82450b370aad35a7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

4.99e-05162203285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

5.18e-051642036fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP6 HOXA4 TMEM121B

5.27e-05165203eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17|GI_large-bowel / Manually curated celltypes from each tissue

ZNF652 PRR7 PDE4D

6.72e-051792036359f30005b17dc5b5c4c8f3a6a38c87ccfe4ee9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

7.77e-05188203e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

7.77e-051882034154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

7.89e-051892038ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

8.02e-0519020311d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

8.02e-05190203b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

8.02e-05190203b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

8.14e-0519120396b78b4e819ea6052334bfcbc7abbf35897df885
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

8.27e-05192203fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GLIS3 STIM2 PDE4D

8.27e-05192203bae236c9f1fac77bce28d0a9cf090100d391ff77
Diseaseleptin measurement, type 2 diabetes mellitus

SP6 GLIS3

4.20e-0516182EFO_0005000, MONDO_0005148
Diseaseasthma

SP6 GLIS3 ZNF652 PDE4D CEBPA

6.85e-05751185MONDO_0004979
DiseaseCalcium channel blocker use measurement

SP6 GLIS3 STIM2

2.79e-04213183EFO_0009930
Diseasetestosterone measurement

GLIS3 CCDC85C NCOR2 ZNF652 IQSEC2

7.99e-041275185EFO_0004908
Diseasethyroid stimulating hormone measurement

GLIS3 ZNF652 PDE4D

9.39e-04323183EFO_0004748
Diseasebalding measurement

GLIS3 FOXD2 NCOR2 PDE4D

1.17e-03792184EFO_0007825
Diseaseage of onset of childhood onset asthma

ZNF652 CEBPA

1.42e-0392182OBA_2001015
DiseaseInhalant adrenergic use measurement

GLIS3 CEBPA

1.55e-0396182EFO_0009941
Diseaseneurotic disorder

GLIS3 PDE4D

1.71e-03101182EFO_0004257
Diseasehematocrit

GLIS3 FOXD2 NCOR2 CEBPA

2.85e-031011184EFO_0004348
Diseaserespiratory system disease

ZNF652 CEBPA

3.48e-03145182EFO_0000684
Diseasetransient cerebral ischemia (biomarker_via_orthology)

PDE4D CEBPA

4.07e-03157182DOID:224 (biomarker_via_orthology)
Diseasehigh density lipoprotein particle size measurement

SP6 NCOR2

4.75e-03170182EFO_0008592
Diseaseage at menarche

SP6 FOXJ3 PDE4D

5.29e-03594183EFO_0004703
Diseasemultiple sclerosis

NCOR2 ZNF652 CEBPA

5.29e-03594183MONDO_0005301
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

SP6 NCOR2

6.89e-03206182EFO_0004612, EFO_0020947
Diseasemonocyte count

GLIS3 NCOR2 TMEM121B CEBPA

7.38e-031320184EFO_0005091
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

SP6 NCOR2

7.49e-03215182EFO_0008317, EFO_0008591
Diseaseeye morphology measurement

GLIS3 TLX1NB

7.69e-03218182EFO_0007858
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

SP6 NCOR2

7.83e-03220182EFO_0004529, EFO_0008317
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

SP6 NCOR2

8.10e-03224182EFO_0004574, EFO_0008317
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

SP6 NCOR2

8.17e-03225182EFO_0008317, EFO_0010351
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

SP6 NCOR2

8.45e-03229182EFO_0004639, EFO_0008317
Diseasenon-high density lipoprotein cholesterol measurement

SP6 GLIS3 CEBPA

8.75e-03713183EFO_0005689

Protein segments in the cluster

PeptideGeneStartEntry
HHHHHHLSVPPPPLM

RBM33

636

Q96EV2
PHSTVPEHHPHPISP

NCOR2

1596

Q9Y618
SHPHHPQSPLSPHSP

IQSEC2

1416

Q5JU85
SPDHHHHVPPPLLPP

CCDC85C

216

A6NKD9
PQFRLLHPHHHLPPP

PDE4D

46

Q08499
APLPPHPHPHPHSVA

MNT

376

Q99583
HPHPHPHSVALPPAH

MNT

381

Q99583
QPHLPTHPHLPTHPH

GOLGA6L1

6

Q8N7Z2
THPHLPTHPHLPTHP

GOLGA6L1

11

Q8N7Z2
PTHPHLPTHPHLPTH

GOLGA6L1

16

Q8N7Z2
LPTHPHLPTHPHLPT

GOLGA6L1

21

Q8N7Z2
HLPTHPHLPTHPHLP

GOLGA6L1

26

Q8N7Z2
PHLPTHPHLPTHPHL

GOLGA6L1

31

Q8N7Z2
HPHLPTHPHLPTHPM

GOLGA6L1

36

Q8N7Z2
QPHLPTHPHLPTHPH

GOLGA6L6

6

A8MZA4
THPHLPTHPHLPTHP

GOLGA6L6

11

A8MZA4
PTHPHLPTHPHLPTH

GOLGA6L6

16

A8MZA4
LPTHPHLPTHPHLPT

GOLGA6L6

21

A8MZA4
HPHHHALPHPPPTHL

PRR7

116

Q8TB68
HTQPSPHPPHRPHGL

FOXJ3

376

Q9UPW0
HPHPHPPPAHLAAPH

CEBPA

191

P49715
PGPPPPYHAHAHLHH

GLIS3

301

Q8NEA6
SPHLHPHPHPSTSTP

HOXA4

301

Q00056
PHPHPHPHPELLLRG

FOXD2

231

O60548
PFLIHPPHLSPHHPP

RNF38

271

Q9H0F5
HHHHAAPPLHLPAPS

TMEM121B

266

Q9BXQ6
LCAPPPHPHAHHLLP

SP6

161

Q3SY56
PPHPLNKQKHHPPHP

TLX1NB

71

P0CAT3
LAPHAPHPSHPRHPH

STIM2

531

Q9P246
PRHPHHPQHTPHSLP

STIM2

541

Q9P246
RPIPHPFSHLHIHPH

ZNF652

541

Q9Y2D9
PHHPHHLPIPPVPHL

ZNF652

556

Q9Y2D9