Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 KLHL22	7.15e-05	82	170	6	GO:1990756
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.04e-04	55	170	5	GO:0042974
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 KLHL22	1.62e-04	95	170	6	GO:0140767
GeneOntologyMolecularFunction	adenosylhomocysteinase activity	AHCYL1 AHCYL2	2.15e-04	3	170	2	GO:0004013
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-sulfur bonds	AHCYL1 AHCYL2	2.15e-04	3	170	2	GO:0046508
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM4 GRM7	4.28e-04	4	170	2	GO:0001642
GeneOntologyBiologicalProcess	transmission of nerve impulse	MAG OTOA DRD5 ANK3 GRM7 SPTBN4 KCND2 KCNQ3	3.97e-06	112	169	8	GO:0019226
GeneOntologyCellularComponent	motile cilium	MKKS CFAP47 PRAMEF7 BBS1 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 DNAH14 SLC9B1 DNAI2 CFAP99	3.75e-05	355	171	12	GO:0031514
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.01e-05	47	171	5	GO:0031462
GeneOntologyCellularComponent	paranode region of axon	MAG ANK3 SPTBN4	3.36e-04	17	171	3	GO:0033270
GeneOntologyCellularComponent	cilium	MKKS CFAP47 PRAMEF7 CACNA1F DRD5 TRAF3IP1 PDGFRA RTTN BBS1 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 WDPCP DNAH14 SLC9B1 DNAI2 CFAP99	4.19e-04	898	171	18	GO:0005929
GeneOntologyCellularComponent	node of Ranvier	ANK3 SPTBN4 KCNQ3	5.53e-04	20	171	3	GO:0033268
MousePheno	enlarged urinary bladder	PRAMEF7 RTTN PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 DNAI2 ZFYVE26	8.21e-06	116	123	8	MP:0011874
MousePheno	abnormal jejunum morphology	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.83e-05	41	123	5	MP:0004002
MousePheno	abnormal spermatogonia proliferation	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	5.55e-05	47	123	5	MP:0002685
Domain	PRAME_family	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	6.00e-07	19	169	5	IPR026271
Domain	ARM-type_fold	RALGAPA1 SAAL1 CAND2 DOCK8 RTTN CKAP5 RIC8B THADA MROH1 PSME4 PELP1 INF2 NBEAL2	1.33e-05	339	169	13	IPR016024
Domain	ARM-like	SAAL1 CAND2 DOCK8 RTTN CKAP5 RIPOR3 RIC8B MROH1 PSME4 PELP1 NBEAL2	3.62e-05	270	169	11	IPR011989
Domain	Chemokine_XCL1/XCL2	XCL2 XCL1	8.14e-05	2	169	2	IPR008105
Domain	L_dom-like	PRAMEF7 ERBB4 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 FBXL6 TSKU RNH1 LRCH4 LINGO4	2.04e-04	328	169	11	IPR032675
Domain	AdoHcyase_NAD	AHCYL1 AHCYL2	2.43e-04	3	169	2	SM00997
Domain	AdoHcyase	AHCYL1 AHCYL2	2.43e-04	3	169	2	SM00996
Domain	AdoHcyase_NAD	AHCYL1 AHCYL2	2.43e-04	3	169	2	PF00670
Domain	ADOHCYASE_1	AHCYL1 AHCYL2	2.43e-04	3	169	2	PS00738
Domain	ADOHCYASE_2	AHCYL1 AHCYL2	2.43e-04	3	169	2	PS00739
Domain	AdoHcyase	AHCYL1 AHCYL2	2.43e-04	3	169	2	PF05221
Domain	Ado_hCys_hydrolase_NAD-bd	AHCYL1 AHCYL2	2.43e-04	3	169	2	IPR015878
Domain	S-Ado-L-homoCys_hydrolase_CS	AHCYL1 AHCYL2	2.43e-04	3	169	2	IPR020082
Domain	Adenosylhomocysteinase	AHCYL1 AHCYL2	2.43e-04	3	169	2	IPR000043
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.65e-08	17	172	5	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.65e-08	17	172	5	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.27e-08	18	172	5	23894331
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.27e-08	18	172	5	39181896
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.27e-08	18	172	5	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.27e-08	18	172	5	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.27e-08	18	172	5	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	3.07e-08	19	172	5	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.07e-08	20	172	5	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.07e-08	20	172	5	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.07e-08	20	172	5	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	6.87e-08	22	172	5	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	8.74e-08	23	172	5	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.37e-07	25	172	5	12620990
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.37e-07	25	172	5	37451217
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.69e-07	26	172	5	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.50e-07	28	172	5	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	3.60e-07	30	172	5	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	5.04e-07	32	172	5	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	8.03e-07	35	172	5	19389355
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	AHCYL1 GGNBP2 SAMD9 MYO19 DHX57 TUBGCP4 LPIN1 TGM2 ARNT PSME4 WDCP TBK1 LRCH4 TMEM223 DNA2	9.44e-07	650	172	15	38777146
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MPO AHCYL1 NUP107 CCT3 MYO19 POLR2C CAPN2 THUMPD3 CKAP5 DHX57 LDHB TGM2 FASN MDN1 FAF2 PSME4 RNH1 INF2 FANCI GLS HERC2 CORO7	1.02e-06	1353	172	22	29467282
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	AHCYL1 ANK3 CAPN2 DHX57 WDCP TBK1 GLS SLX4	1.97e-06	167	172	8	25659891
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KIF26A RTTN ATG2A TNRC6C PLEKHH3 TRAK1 FASN THADA INTS5 MDN1 MROH1 PSME4 INF2 FANCI NBEAL2 ZFYVE26 HERC2 ANKRD33B IGSF3	2.65e-06	1105	172	19	35748872
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	DRD5 GPR22 LPAR4 GRM4 GRM7 ADGRE4P	2.76e-06	79	172	6	12679517
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	3.25e-06	46	172	5	17287250
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.94e-06	50	172	5	31806660
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	MAG PRAMEF7 PCBP3 CAND2 CCT3 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 LDHB MROH1 PSME4 RNH1	5.21e-06	564	172	13	21565611
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.03e-05	58	172	5	31598710
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MKKS CAND2 NUP107 MYO19 POLR2C OXA1L MDN1 FAF2 FANCI TBK1 PANK4 HERC2 DNA2	1.12e-05	606	172	13	36538041
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.13e-05	59	172	5	11279525
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	MAG RALGAPA1 NAT8L PCBP3 PCLO POLR2C DHX57 TUBGCP4 PLEKHH3 PABPC3 DNA2	2.09e-05	462	172	11	31138677
Pubmed	Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.	XCL2 XCL1	2.43e-05	2	172	2	8849694
Pubmed	Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.	ARNT ARNT2	2.43e-05	2	172	2	15466261
Pubmed	Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.	TFAP2C PELP1	2.43e-05	2	172	2	33269540
Pubmed	Endogenous mesenchymal stromal cells in bone marrow are required to preserve muscle function in mdx mice.	PDGFRA DMD	2.43e-05	2	172	2	25408548
Pubmed	Thyroid dysfunction in Chinese hepatitis C patients: Prevalence and correlation with TPOAb and CXCL10.	TPO CXCL10	2.43e-05	2	172	2	26361424
Pubmed	Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.	PDGFRA BBS1	2.43e-05	2	172	2	23160237
Pubmed	Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.	MPO TPO	2.43e-05	2	172	2	3654979
Pubmed	Combinatorial activation of the WNT-dependent fibrogenic program by distinct complement subunits in dystrophic muscle.	PDGFRA DMD	2.43e-05	2	172	2	37927228
Pubmed	Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity.	XCL2 XCL1	2.43e-05	2	172	2	9834111
Pubmed	Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localization.	TGM2 ARNT	2.43e-05	2	172	2	23085038
Pubmed	T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production.	XCL2 XCL1	2.43e-05	2	172	2	22528127
Pubmed	Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.	XCL2 XCL1	2.43e-05	2	172	2	25497737
Pubmed	Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.	XCL2 XCL1	2.43e-05	2	172	2	19097989
Pubmed	Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.	XCL2 XCL1	2.43e-05	2	172	2	9029087
Pubmed	The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation.	XCL2 XCL1	2.43e-05	2	172	2	31413355
Pubmed	Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.	ARNT ARNT2	2.43e-05	2	172	2	17023418
Pubmed	Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling.	TGM2 ARNT	2.43e-05	2	172	2	18375543
Pubmed	Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia.	GRM4 GRM7	2.43e-05	2	172	2	19351574
Pubmed	Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.	DMD ALPL	2.43e-05	2	172	2	19151073
Pubmed	Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity.	COL7A1 TGM2	2.43e-05	2	172	2	24732400
Pubmed	Adenovirus-mediated intratumoral lymphotactin gene transfer potentiates the antibody-targeted superantigen therapy of cancer.	XCL2 XCL1	2.43e-05	2	172	2	12226740
Pubmed	Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice.	XCL2 XCL1	2.43e-05	2	172	2	24778093
Pubmed	Molecular cloning and functional characterization of human lymphotactin.	XCL2 XCL1	2.43e-05	2	172	2	7602097
Pubmed	TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts.	PDGFRA DMD	2.43e-05	2	172	2	32434871
Pubmed	Monomeric solution structure of the prototypical 'C' chemokine lymphotactin.	XCL2 XCL1	2.43e-05	2	172	2	11601972
Pubmed	Molecular cloning of a novel C or gamma type chemokine, SCM-1.	XCL2 XCL1	2.43e-05	2	172	2	7875320
Pubmed	In-vitro activation of cytotoxic T lymphocytes by fusion of mouse hepatocellular carcinoma cells and lymphotactin gene-modified dendritic cells.	XCL2 XCL1	2.43e-05	2	172	2	17990361
Pubmed	Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia.	XCL2 XCL1	2.43e-05	2	172	2	8757601
Pubmed	The chemokines CXCL10 and XCL1 recruit human annulus fibrosus cells.	CXCL10 XCL1	2.43e-05	2	172	2	21270681
Pubmed	A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells.	XCL2 XCL1	2.43e-05	2	172	2	30542351
Pubmed	A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption.	ANK3 ARHGEF10	2.43e-05	2	172	2	31372216
Pubmed	Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein.	XCL2 XCL1	2.43e-05	2	172	2	14734774
Pubmed	Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin.	XCL2 XCL1	2.43e-05	2	172	2	11181058
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	CFAP47 PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 TADA1 FANCI LRCH4	3.86e-05	326	172	9	17015433
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SCFD2 RALGAPA1 AHCYL1 CAND2 ANK3 NUP107 ATAD5 SNX19 THADA OXA1L MDN1 FAF2 SACS ARHGEF10 INF2 GLS PANK4 PEAK1 HERC2 DNA2	5.04e-05	1487	172	20	33957083
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	ANK3 POLR2C CAPN2 DHX57 TUBGCP4 OXA1L MDN1 FAF2 RNH1 TBK1 GLS	5.59e-05	515	172	11	31617661
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	PRAMEF7 PCBP3 THUMPD3 PRAMEF12 TNRC6C PRAMEF8 PRAMEF1 PRAMEF13 PABPC3	6.24e-05	347	172	9	16033648
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NUP107 CCT3 CKAP5 DHX57 OR4D2 FASN HERC2	6.99e-05	202	172	7	33005030
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 CAND2 KIF26A PHRF1 ATG2A INTS5 PSME4 NBEAL2 AGAP9 DNA2 IGSF3	7.10e-05	529	172	11	14621295
Pubmed	βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy.	ANK3 SPTBN4	7.27e-05	3	172	2	29861105
Pubmed	Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair.	PDGFRA DMD	7.27e-05	3	172	2	34078594
Pubmed	The mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein maps to distal chromosome 9.	MAG COL7A1	7.27e-05	3	172	2	8875894
Pubmed	Resequencing three candidate genes for major depressive disorder in a Dutch cohort.	PCLO GRM7	7.27e-05	3	172	2	24278217
Pubmed	PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia.	COL7A1 PDGFRA	7.27e-05	3	172	2	21464317
Pubmed	A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.	XCL2 XCL1	7.27e-05	3	172	2	28550205
Pubmed	Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation.	XCL2 XCL1	7.27e-05	3	172	2	9199871
Pubmed	cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).	ARNT ARNT2	7.27e-05	3	172	2	8657146
Pubmed	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	GRM4 GRM7	7.27e-05	3	172	2	33068816
Pubmed	Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids.	FASN GLS	7.27e-05	3	172	2	26134042
Pubmed	Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration.	MAG PDGFRA	7.27e-05	3	172	2	10366628
Pubmed	Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.	ARNT ARNT2	7.27e-05	3	172	2	18096572
Pubmed	Identification of single C motif-1/lymphotactin receptor XCR1.	XCL2 XCL1	7.27e-05	3	172	2	9632725
Pubmed	Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.	XCL2 XCL1	7.27e-05	3	172	2	20541533
Pubmed	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.	GRM4 GRM7	7.27e-05	3	172	2	9473604
Pubmed	KCNQ2 is a nodal K+ channel.	ANK3 KCNQ3	7.27e-05	3	172	2	14762142
Pubmed	Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus.	MKKS BBS1	7.27e-05	3	172	2	12837689
Pubmed	[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier.	ANK3 SPTBN4	7.27e-05	3	172	2	11807096
Pubmed	Microglial Inhibition Influences XCL1/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy.	XCL2 XCL1	7.27e-05	3	172	2	27387353
Pubmed	Expression of Arnt and Arnt2 mRNA in developing murine tissues.	ARNT ARNT2	7.27e-05	3	172	2	12502753
Pubmed	Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex.	ANK3 SPTBN4	7.27e-05	3	172	2	33397944
Pubmed	Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.	ANK3 SPTBN4	7.27e-05	3	172	2	27356871
Pubmed	PDGFR-alpha inhibits melanoma growth via CXCL10/IP-10: a multi-omics approach.	PDGFRA CXCL10	7.27e-05	3	172	2	27764787
Pubmed	Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.	ARNT ARNT2	7.27e-05	3	172	2	36343253
Pubmed	Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.	XCL2 XCL1	7.27e-05	3	172	2	19913446
Pubmed	Whole-exome sequencing reveals common and rare variants in immunologic and neurological genes implicated in achalasia.	LPIN1 ESYT3	7.27e-05	3	172	2	34197731
Pubmed	Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.	ATAD5 FANCI	7.27e-05	3	172	2	21896657
Pubmed	The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers.	FASN GLS	7.27e-05	3	172	2	32698888
Pubmed	Lymphotactin acts as an innate mucosal adjuvant.	XCL2 XCL1	7.27e-05	3	172	2	9973465
Cytoband	1p36.21	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.11e-06	63	172	5	1p36.21
Cytoband	11q12.3	INTS5 CSKMT TMEM223	3.96e-04	38	172	3	11q12.3
Cytoband	17q25	GRIN2C FASN DNAI2	4.28e-04	39	172	3	17q25
GeneFamily	PRAME family	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	5.58e-07	24	125	5	686
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCC FANCI SLX4	3.37e-04	20	125	3	548
GeneFamily	Bardet-Biedl syndrome associated\|BBSome	MKKS BBS1 WDPCP	3.92e-04	21	125	3	980
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM4 GRM7	1.29e-03	8	125	2	281
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	PRAMEF7 LPAR4 RTTN BBS1 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 MEAK7 TRAK1 KCND2 ASB7 WDCP ZFYVE26 ALOXE3 FRG2C	1.69e-07	497	170	16	MM863
Coexpression	NOURUZI_NEPC_ASCL1_TARGETS	TPO PCBP3 CAND2 KIF26A GRIN2C GRM4 LPIN1 MROH1 EPHB1	1.02e-06	159	170	9	M46420
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	2.59e-06	34	170	5	MM955
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	PRAMEF7 COL7A1 ANK3 RTTN BBS1 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 MEAK7 TRAK1 SLC9B1 SACS ASB7 WDCP ZFYVE26 ALOXE3 FRG2C	5.56e-06	807	170	18	MM855
Coexpression	KOHOUTEK_CCNT2_TARGETS	PRAMEF7 LMNTD2 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	1.48e-05	81	170	6	MM938
Coexpression	YAMAZAKI_TCEB3_TARGETS_DN	PRAMEF7 CCT3 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 LDHB TFAP2C MDN1	2.19e-05	232	170	9	MM1019
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	3.45e-05	57	170	5	MM1262
Coexpression	DESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR	PRAMEF7 ATP10B PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.38e-05	98	170	6	MM3656
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PSME4	4.38e-05	98	170	6	MM592
Coexpression	HUANG_GATA2_TARGETS_DN	PRAMEF7 NUP107 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13	4.38e-05	98	170	6	MM942
Coexpression	GSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_DN	DOCK8 CAPN2 ATG2A TNRC6C MROH1 TBK1 PANK4 HERC2	4.92e-05	199	170	8	M316
Coexpression	GSE3982_DC_VS_NEUTROPHIL_LPS_STIM_UP	MKKS GPR15 NUP107 CXCL10 CKAP5 LDHB LPIN1 IGSF3	4.92e-05	199	170	8	M5391
Coexpression	GSE14308_TH1_VS_NAIVE_CD4_TCELL_DN	TRAF3IP1 PHRF1 TUBGCP4 TFAP2C KCND2 ASXL3 XCL1 SLX4	5.09e-05	200	170	8	M3377
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ERBB4 ANK3 RIPOR3 AHCYL2 ESYT3 FASN GLS ALPL	6.91e-07	187	172	8	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	ERBB4 ANK3 PCLO DNAH14 ESYT3 FASN KCNQ3 ALPL	8.10e-07	191	172	8	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|390C / Donor, Lineage, Cell class and subclass (all cells)	RALGAPA1 CXCL10 RTTN TUBGCP4 CD70 CSKMT SLX4	2.44e-06	155	172	7	afdd0aba0f3788c2fb916ffb453c5dd7cde2304c
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NAT8L GRM4 SPTBN4 MROH1 NBEAL2 ARNT2 KCNK17	4.16e-06	168	172	7	17d46f993dc4ae22b8087808582aba77f5c61892
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CAPN12 DNAH14 TGM2 XCL2 LINGO4 KCNK17 XCL1	4.85e-06	172	172	7	980e8b9e1ceeb0dec9eb9ef95c139e5ffe99b6e4
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|343B / Donor, Lineage, Cell class and subclass (all cells)	CAND2 CXCL10 TUBGCP4 MROH1 CD70 PEAK1 CORO7	6.08e-06	178	172	7	ec6364432d37a32f5152d36d89f5e96dddb72a9d
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ERBB4 ANK3 ESYT3 FASN KCNQ3 ALPL IGSF3	7.29e-06	183	172	7	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	ERBB4 ANK3 PCLO AHCYL2 DNAH14 KCNQ3 ALPL	8.69e-06	188	172	7	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB4 ANK3 PCLO DNAH14 FASN KCNQ3 ALPL	9.96e-06	192	172	7	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	ERBB4 ANK3 PCLO DNAH14 FASN KCNQ3 ALPL	9.96e-06	192	172	7	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NUP107 ATAD5 RTTN CKAP5 FANCC FANCI DNA2	1.03e-05	193	172	7	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-gd_T\|ICU-SEP / Disease, condition lineage and cell class	CAPN12 PCDHGA6 ESYT3 XCL2 AGAP9 XCL1 B4GALT3	1.22e-05	198	172	7	b40899f8f5f32420fb4574069dd7afd9e7e70d91
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-NK_CD56bright\|Influenza_Severe / Disease, condition lineage and cell class	CAPN12 ATAD5 WDPCP ARHGEF10 XCL2 CD70 XCL1	1.26e-05	199	172	7	784e7e7ede2baa28ede600834813e6de2240bfdf
ToppCell	LPS-antiTNF-Endothelial-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TUBGCP4 GRM7 TFAP2C PELP1 PANK4 ALOXE3	2.06e-05	144	172	6	75b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell	severe_COVID-19-NK_CD56bright\|severe_COVID-19 / disease group, cell group and cell class (v2)	CAPN12 IL12RB2 OR4D1 XCL2 FRMPD3 XCL1	3.47e-05	158	172	6	c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCell	3'_v3-Lung-Lymphocytic_Invariant-Inducer-like-ILC3\|Lung / Manually curated celltypes from each tissue	PCLO ARHGEF10 XCL2 LINGO4 KCNK17 XCL1	4.73e-05	167	172	6	0614d077b47a87f726068615548d0b0a216627be
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_C\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATAD5 CXCL10 RIPOR3 ASB7 KCNK17 XCL1	4.89e-05	168	172	6	0372c06b70f0ba95bf8cd1363ca7c5f31207f094
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PDGFRA RIPOR3 SLCO5A1 DNAI2 CD70 ANKRD33B	5.40e-05	171	172	6	341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAAL1 RTTN GARIN5A LDHB MROH1 PLIN1	5.58e-05	172	172	6	e15ab284df6dd241d4481f98864b18c39d757b8c
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	AHCYL1 ERBB4 ANK3 PCLO CDH9 IGSF3	6.33e-05	176	172	6	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	Adult-Immune-enucleated_erythrocyte-D231\|Adult / Lineage, Cell type, age group and donor	MKKS HGFAC WDCP TMEM223 ANKRD33B B4GALT3	6.54e-05	177	172	6	15ee303fb6caea1fd645c3b777666196ce500a1c
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 IL12RB2 GARIN5A THADA ARNT2 DNAI2	6.54e-05	177	172	6	291231b1520c135e92739e201495fe1935efa927
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ERBB4 ANK3 AHCYL2 FASN KCNQ3 ALPL	7.17e-05	180	172	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CAND2 CXCL10 TUBGCP4 MROH1 CD70 PEAK1	7.62e-05	182	172	6	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 PDE10A WDPCP SLCO5A1 GALNT17 DMD	7.62e-05	182	172	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	IPF-Epithelial-ATII\|IPF / Disease state, Lineage and Cell class	ERBB4 ANK3 ESYT3 FASN KCNQ3 ALPL	8.34e-05	185	172	6	563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ERBB4 ANK3 ESYT3 FASN KCNQ3 ALPL	8.59e-05	186	172	6	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	10x5'v1-week_12-13-Lymphocytic_T-T_NK-NK_T_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CAPN12 ANK3 LPIN1 XCL2 LINGO4 XCL1	8.59e-05	186	172	6	b099cb0902e9afb11218d70407d3cab212343c6d
ToppCell	Control-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ERBB4 ANK3 ESYT3 FASN KCNQ3 ALPL	8.59e-05	186	172	6	f4b6e401e19a71beddc73d8a1e08359f7c4025cf
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	ERBB4 ANK3 ESYT3 FASN ALPL IGSF3	9.11e-05	188	172	6	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	CAPN12 ERBB4 FASN MROH1 KCNQ3 ALPL	9.38e-05	189	172	6	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	BAL-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PCBP3 LPIN1 SACS FANCI CD70 FCRL5	9.66e-05	190	172	6	da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ERBB4 ANK3 ESYT3 FASN KCNQ3 ALPL	9.66e-05	190	172	6	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	ERBB4 ANK3 SLCO5A1 TGM2 GALNT17 MROH1	9.66e-05	190	172	6	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PCBP3 LPIN1 SACS FANCI CD70 FCRL5	9.66e-05	190	172	6	42312f7d79fe889397d32910b625793e2535cc26
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PCBP3 LPIN1 SACS FANCI CD70 FCRL5	9.66e-05	190	172	6	682418a7a2096743112eae3790d40e7e600612c0
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ERBB4 ANK3 WDPCP SLCO5A1 GALNT17 DMD	1.05e-04	193	172	6	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	CKAP5 TUBGCP4 GDE1 FANCC SLCO5A1 FANCI	1.05e-04	193	172	6	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	DNAH14 TGM2 XCL2 LINGO4 KCNK17 XCL1	1.05e-04	193	172	6	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col6a1_Fezf2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CAPN12 DRD5 PABPC4L GALNT17 INF2	1.11e-04	122	172	5	e96aec5af0ed1d8f4cc99fde59dd6998bbc1acbd
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AHCYL1 ERBB4 ANK3 CAPN2 LDHB IGSF3	1.11e-04	195	172	6	3123e02d2894c83962ba402085b5e6422ebf8c73
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	CAPN12 IL12RB2 LPIN1 XCL2 PEAK1 XCL1	1.11e-04	195	172	6	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK3 AHCYL2 ESYT3 FASN GLS ALPL	1.14e-04	196	172	6	7e5addaa844e66f8160e05858c341866a80aed23
ToppCell	lymphoid-T_cell-Regulatory_T_cell\|World / Lineage, cell class and subclass	CAPN12 CAPN2 ATG2A INF2 XCL2 XCL1	1.14e-04	196	172	6	42a4d706382be33d552ece1d0598d073857a8d4e
ToppCell	ASK440-Epithelial-Type_2\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	CAPN12 ANK3 AHCYL2 ESYT3 FASN ALPL	1.14e-04	196	172	6	754b4202b617165c6994a0b5a9b1e486dccdd44d
ToppCell	ILEUM-non-inflamed-(6)_ILC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CAPN12 GDE1 TGM2 XCL2 LINGO4 XCL1	1.18e-04	197	172	6	76a233eb9611d24b9bb9f4359c26606332a3c29e
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ANK3 PCLO LDHB NBEAL2 DMD ALPL	1.18e-04	197	172	6	4ae08ccb6f1da626c4f0fb0140a2811cb6e31ba1
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN12 IL12RB2 GPR15 XCL2 FRMPD3 XCL1	1.18e-04	197	172	6	e8861abffbb7169f1923fad6e565865eee22f310
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK3 AHCYL2 ESYT3 FASN GLS ALPL	1.18e-04	197	172	6	bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MPO PCBP3 ATAD5 PCLO SACS FANCI	1.21e-04	198	172	6	844f534551483c89ef789d1cfeb4680e54f794b2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCLO SPTBN4 GALNT17 KCND2 GLS KCNQ3	1.21e-04	198	172	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	lymphoid-T_cell-Regulatory_T_cell\|T_cell / Lineage, cell class and subclass	CAPN12 CAPN2 INF2 TBK1 XCL2 XCL1	1.21e-04	198	172	6	6773c6043ef4a3d9e9700330b6386431ee66abdc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK3 PCLO SPTBN4 GALNT17 GLS KCNQ3	1.21e-04	198	172	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDGFRA MAMLD1 ATP10B GRM7 ARNT2 ASTN1	1.24e-04	199	172	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERBB4 PDGFRA ATP10B GRM7 ARNT2 ASTN1	1.24e-04	199	172	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDGFRA MAMLD1 ATP10B GRM7 ARNT2 ASTN1	1.24e-04	199	172	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERBB4 ANK3 ESYT3 FASN GLS ALPL	1.24e-04	199	172	6	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	ANK3 PCLO SPTBN4 GALNT17 GLS KCNQ3	1.28e-04	200	172	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ANK3 AHCYL2 ESYT3 FASN KCNQ3 ALPL	1.28e-04	200	172	6	acc771a902cf2f060c3eb9aedb72a256f5778a6c
ToppCell	Parenchyma_COVID-19-Epithelial-TX-AT2-2\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	ANK3 AHCYL2 ESYT3 FASN KCNQ3 ALPL	1.28e-04	200	172	6	ceb613ac6cdf0e3e6bb3f04d89034e18a524cefb
ToppCell	mild-NK_CD56bright\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CAPN12 IL12RB2 DNAH14 XCL2 PEAK1 XCL1	1.28e-04	200	172	6	6de701985a0b92a7dece1b0e4a76e13756ccc0dd
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	CAPN12 NUP107 PHRF1 DNAH14 XCL2 XCL1	1.28e-04	200	172	6	c2df917900872453ea17a39928e39d071a6d3339
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANK3 AHCYL2 ESYT3 FASN KCNQ3 ALPL	1.28e-04	200	172	6	eb44d1f80ecaac3a022cd04ab16dc36151e45488
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN12 CACNA1F CAPN2 DMD	4.18e-05	36	159	4	DOID:11723 (implicated_via_orthology)
Disease	Fanconi anemia	FANCC FANCI SLX4	5.35e-05	14	159	3	cv:C0015625
Disease	Bipolar Disorder	TPO ERBB4 DRD5 ANK3 PCLO PDE10A GRM4 GRM7 TGM2 ARHGEF10 KCNQ3	5.94e-05	477	159	11	C0005586
Disease	Bardet-Biedl syndrome 1 (disorder)	MKKS BBS1 WDPCP	9.88e-05	17	159	3	C2936862
Disease	Bone marrow hypocellularity	FANCC FANCI SLX4	1.18e-04	18	159	3	C1855710
Disease	Bardet-Biedl syndrome	MKKS BBS1 WDPCP	1.18e-04	18	159	3	cv:C0752166
Disease	lymphotactin measurement	XCL2 XCL1	1.72e-04	4	159	2	EFO_0008214
Disease	obesity (implicated_via_orthology)	MKKS CAPN2 BBS1 LPIN1 THADA CORO7 PLIN1	1.73e-04	215	159	7	DOID:9970 (implicated_via_orthology)
Disease	Fanconi Anemia	FANCC FANCI SLX4	3.24e-04	25	159	3	C0015625
Disease	Pancytopenia	FANCC FANCI SLX4	3.64e-04	26	159	3	C0030312
Disease	Acute monocytic leukemia	FANCC FANCI SLX4	3.64e-04	26	159	3	C0023465
Disease	MYELODYSPLASTIC SYNDROME	SAMD9 FANCC FANCI SLX4	4.78e-04	67	159	4	C3463824
Disease	Miller Dieker syndrome	FANCC FANCI SLX4	5.06e-04	29	159	3	C0265219
Disease	Abnormality of radial ray	FANCC FANCI SLX4	7.44e-04	33	159	3	C4228778
Disease	Lung diseases	MPO PDGFRA DOCK8 DNAI2	8.49e-04	78	159	4	C0024115
Disease	survival time	XCL2 XCL1	1.01e-03	9	159	2	EFO_0000714
Disease	tongue squamous cell carcinoma (is_marker_for)	ERBB4 FANCC FANCI	1.04e-03	37	159	3	DOID:0050865 (is_marker_for)
Disease	4-vinylphenol sulfate measurement	GPR15 EPHB1	1.26e-03	10	159	2	EFO_0021149
Disease	Fanconi anemia (is_implicated_in)	FANCC FANCI	1.26e-03	10	159	2	DOID:13636 (is_implicated_in)
Disease	Fetal Alcohol Spectrum Disorders	ANK3 PDGFRA	2.16e-03	13	159	2	C2985290
Disease	Bardet-Biedl syndrome (is_implicated_in)	MKKS BBS1	2.52e-03	14	159	2	DOID:1935 (is_implicated_in)
Disease	HOMA-B	CAND2 ARHGEF10 FCRL5	3.28e-03	55	159	3	EFO_0004469
Disease	fatty liver disease (is_marker_for)	CXCL10 ALPL	3.72e-03	17	159	2	DOID:9452 (is_marker_for)
Disease	Fetal Alcohol Syndrome	ANK3 PDGFRA	3.72e-03	17	159	2	C0015923
Disease	androstenedione measurement, estrone measurement	OR4D1 OR4D2	4.17e-03	18	159	2	EFO_0007970, EFO_0007972
Disease	Carcinoma of bladder	FANCC PEAK1	4.17e-03	18	159	2	C0699885
Disease	Tourette syndrome, schizophrenia	GGNBP2 MYO19	4.17e-03	18	159	2	EFO_0004895, MONDO_0005090
Disease	Colorectal Carcinoma	MPO COL7A1 SETD4 HTR3C LPIN1 TGM2 ARNT SACS PANK4 DMD	4.89e-03	702	159	10	C0009402
Disease	myeloid white cell count	SCFD2 MPO SAAL1 DOCK8 NHLRC2 MEAK7 TGM2 THADA TADA1 GALNT17 FCRL5 NAIF1	4.94e-03	937	159	12	EFO_0007988
Disease	Sarcomatoid Renal Cell Carcinoma	LDHB SPTBN4 TGM2 YIPF3	5.16e-03	128	159	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	LDHB SPTBN4 TGM2 YIPF3	5.16e-03	128	159	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	LDHB SPTBN4 TGM2 YIPF3	5.16e-03	128	159	4	C1266044
Disease	Papillary Renal Cell Carcinoma	LDHB SPTBN4 TGM2 YIPF3	5.16e-03	128	159	4	C1306837
Disease	Renal Cell Carcinoma	LDHB SPTBN4 TGM2 YIPF3	5.16e-03	128	159	4	C0007134
Disease	Astigmatism	TRAF3IP1 PDGFRA GRM7 HERC2	5.31e-03	129	159	4	HP_0000483

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVSPCLTLASLTLRE	nan	141	Q6ZRM9
ESRLCNTVLITGPTG	ATAD5	1121	Q96QE3
CLVAIGRLQVTSSPN	ARNT	336	P27540
VRLLGVCLSPTIQLV	ERBB4	781	Q15303
RLSSQLLPELCTFVV	ESYT3	26	A0FGR9
LERPCTLALLVGSQL	B4GALT3	6	O60512
LPGHQRLSVTSLLVC	ARHGEF10	1156	O15013
PCTELSLGQQLLRAT	AGAP9	626	Q5VTM2
TTPLQLAIIRERSSC	ASB7	151	Q9H672
TEVFCSVPGRLSLLS	TFAP2C	221	Q92754
SSGLPRCLLTLILLQ	BTN1A1	6	Q13410
LPNITLGARILDTCS	GRM4	96	Q14833
SCLLGLPTLLSRELT	GPR15	161	P49685
LTGINRTEPEVLCSI	ADGRE4P	241	Q86SQ3
PARQSALLCLTVSLL	HTR3C	6	Q8WXA8
CSLNLRGTRVTPSTV	FBXL6	476	Q8N531
CRLLVSDIQTIQPSL	DMD	1091	P11532
TTLLEVSPGLSTLQR	DNAI2	476	Q9GZS0
TLCTNLTGTLLPSRN	CD70	166	P32970
ALTSTVPDLLCLLAR	C5orf38	16	Q86SI9
LALSRCSLEVILPSV	ATG2A	806	Q2TAZ0
QLTTISLIIRCLEPD	ASTN1	1111	O14525
LGPEELRSLLTTQCG	ATXN7L3	196	Q14CW9
TLPATCTSLRELPLV	ASXL3	1551	Q9C0F0
VTVRLPQGTCLTFSL	ATP10B	746	O94823
QRLTDCVLSVLTPRS	ANKRD33B	281	A6NCL7
LVAIGRLQVTSSPVC	ARNT2	311	Q9HBZ2
ARTLASPNIVVILCG	RAB4B	106	P61018
LGPSQVVTACLLTLL	DRD5	36	P21918
TSRSLLRQPDISCIL	NUP107	66	P57740
VSATLRRAQPLVTLC	GLS	21	O94925
LQSLPSELCGLSSLR	LRCH4	171	O75427
CELISQLRALETQPT	CFAP99	461	D6REC4
LGATLCAINITEIPL	OTOA	966	Q7RTW8
TGLSLILCQLSLPSI	PDGFRA	16	P16234
TLANPLRRSCISIVE	CACNA1F	76	O60840
PRQLGLTECRVSISS	EPHB1	381	P54762
NLRTAAPTVCLLVLS	FANCI	1076	Q9NVI1
VPQVLRLACTDTSLL	OR4D2	181	P58180
SGLNGLVTCSIPRSL	PCDHGA6	376	Q9Y5G7
LRTSIQTLCKSALPL	TRAF3IP1	586	Q8TDR0
PVDFSSTQILLCLVR	MKKS	141	Q9NPJ1
SQSCSLLVRLVPVLS	MDN1	4601	Q9NU22
LTVTLSCGRPSIRTT	MAD2L1BP	241	Q15013
GLRNCTLLLSNVSPE	MAG	96	P20916
SREVLSALSQLVPCV	GGNBP2	76	Q9H3C7
RICNLLGEATIISLP	NAIF1	131	Q69YI7
TRVNPVTLETVLRCL	MYO19	41	Q96H55
LALTQTALRLIGPSC	HERC2	1811	O95714
SLLTTCSSDVPLLRE	HERC2	2106	O95714
GTARTICQDSLPLLL	ALOXE3	116	Q9BYJ1
PLILNVSCSSVVLRT	LPAR4	216	Q99677
TVLPILTLLDSRVSC	KCNQ3	746	O43525
ILLGSTVNITCSLKP	IL12RB2	41	Q99665
RRTICIDSPSVLISV	DSG4	501	Q86SJ6
ALSPVTQCVLESVLR	CORO7	296	P57737
AVLRSNGLPVTRICT	PCLO	2466	Q9Y6V0
PVTLTCETQLSLERS	FCRL5	206	Q96RD9
KLILSQLETPGRVCS	KCNK17	261	Q96T54
STVPQLLINLCGVDR	OR2Y1	76	Q8NGV0
GNLLILVTVISDPCL	OR4K14	41	Q8NGD5
SGTRIQSVLCLPIVT	PDE10A	181	Q9Y233
QISLPRIICDNTGIT	MPO	696	P05164
RGCTSVTTALSLPEL	PEAK1	1071	Q9H792
LSRVICDNTGLTRVP	TPO	691	P07202
LSECLRVLNPQGTLI	CSKMT	181	A8MUP2
LTAISTQRCLSVLFP	MRGPRD	116	Q8TDS7
GQSIEIPSACISRLT	PHRF1	701	Q9P1Y6
LSTIQIRCVERTPLS	KCND2	556	Q9NZV8
RPSLCQFILLGTTSV	MUL1	6	Q969V5
TLSGCIDIIVIRQPN	LPIN1	26	Q14693
SRCPERGLLTTTVTL	KIF26A	1006	Q9ULI4
PSETSVLNRLCRLGT	TUBGCP4	36	Q9UGJ1
GTSSQIRSPLLCDVI	GARIN5A	16	Q6IPT2
VPLLSIRGCATLLLS	LMNTD2	441	Q8IXW0
LCSSLDLTTLVPERQ	MEAK7	221	Q6P9B6
SLVQVSCLRIPAVRT	OXA1L	326	Q15070
VLLLRVSCTVGVQLP	MROH1	1226	Q8NDA8
LTSLLGLRPECEQSA	PELP1	181	Q8IZL8
ACESLTRVQLSPDLL	HGFAC	366	Q04756
TSVCNPRFLISILTG	OR6C76	71	A6NM76
VLAACESLLTSRQLP	INF2	741	Q27J81
IRLSPVTACAGQTLQ	NHLRC2	601	Q8NBF2
PILSIRICRDLITSG	PABPC3	36	Q9H361
TLRLVVPASQCGSLI	PCBP3	131	P57721
PNLITCRLTSLSIFQ	PANX3	256	Q96QZ0
ERLLLVQTGSSSPCL	PANK4	686	Q9NVE7
LQRVLQLPVVSGTCE	PLIN1	21	O60240
LVLAIGTCLTNSLVP	ALPL	6	P05186
VDSQLSAILPALSRC	PRAMEF12	361	O95522
SPLTCEQLTLLTRLR	FRG2C	201	A6NGY1
TLLAQTELLPSLISC	WDPCP	371	O95876
LPTLRSTPTDLILCV	CKAP5	1006	Q14008
TSTPREIGLRTCEQL	CAPN12	586	Q6ZSI9
LLLVTRSPVNACLLT	GDE1	21	Q9NZC3
IRVLDTSPTLQSIIC	IGSF3	1106	O75054
NSISGLAACVLTLPR	KLHL22	581	Q53GT1
SIICLNSSRLEPLVL	DOCK8	776	Q8NF50
TNELLTVLRQCVASP	FRMPD3	1631	Q5JV73
LCTCPRGSRIISTIV	DHX57	1366	Q6P158
GVPLSRTVRCTCISI	CXCL10	21	P02778
ASLSRVCVPLITLTD	FANCC	181	Q00597
GTTTLLPDTRCLVDN	GALNT17	516	Q6IS24
GDTTPNLRLLCSITG	ANK3	1236	Q12955
KIRTPLLLCAGTQVS	DNAH14	856	Q0VDD8
LGCTSRLVITPLTDR	DNAH14	1131	Q0VDD8
QCSLIRSLTPTSNLL	MAMLD1	476	Q13495
LPNVTLGARILDTCS	GRM7	96	Q14831
SLPCILNARGLTSVI	LDHB	291	P07195
TLLPLVSRRVCTTAG	COL7A1	206	Q02388
VLNTTILCLGPSDLL	GPR22	331	Q99680
ALCATRQEPLLIGST	FASN	311	P49327
QNTSTTRPVLGLLVC	BBS1	506	Q8NFJ9
SRLEICNLTPDTLTS	CAPN2	336	P17655
PTAIRTLIQCLGSVG	CAND2	231	O75155
TTVTCLLDRNLSVLP	DNA2	541	P51530
SAILPVLSRCSQLST	PRAMEF8	366	Q5VWM4
PTLLETSRLLLTCLS	SAAL1	151	Q96ER3
GQTCVELIRLRIPSL	SACS	811	Q9NZJ4
PIQSSTGTLTIRVCA	CDH9	576	Q9ULB4
TTIIISCLPNEGTLQ	CFAP47	321	Q6ZTR5
RNSTLCVQIPTVRLL	CFAP47	1336	Q6ZTR5
LCSLNTLLAGTSRLP	DELE1	456	Q14154
TLERCNLSTVPGLAL	LINGO4	186	Q6UY18
LSAILPGLSRCSQLT	PRAMEF13	366	Q5VWM6
VPQVLRLACTDTSLL	OR4D1	181	Q15615
SLIDLLTCTTTLPNA	OR52N5	76	Q8NH56
STVGPVLSIRICRDQ	PABPC4L	31	P0CB38
LTPILRLSCTDTSVN	OR1M1	181	Q8NGA1
SSLSRLLQSCLLVEP	RTTN	1686	Q86VV8
SSSSETLGIPLIREC	RHNO1	101	Q9BSD3
NTIRTLLSTLPSCTD	THADA	1381	Q6YHU6
LTPQIDGSTLRTLCL	TNRC6C	1521	Q9HCJ0
GRLLNLSCSTVPTFV	AHCYL2	521	Q96HN2
TPTQLLLRDIQESCG	PLEKHH3	206	Q7Z736
ILTRCQILVSTPDGA	TADA1	66	Q96BN2
EGLTPVLSLLTECSR	RIC8B	361	Q9NVN3
RLLNLSCSTVPTFVL	AHCYL1	441	O43865
ANIILSCIQPTSRLV	SAMD9	1391	Q5K651
TALRTLCTLGPNETA	NBEAL2	816	Q6ZNJ1
NTLCAPEVISLINTR	FAF2	191	Q96CS3
ITACAQPSAIIVTLR	SLCO5A1	661	Q9H2Y9
SSLLVPGLTCTQRQR	RPP21	66	Q9H633
SLPESCLLTTDTVIR	SETD4	76	Q9NVD3
VIPRTLIQNCGASTI	CCT3	446	P49368
PLIQTLTLCLGAITT	MT-ND5	271	P03915
LSAILPGLSRCSQLT	PRAMEF1	366	O95521
TTLTPELLLQIRCLV	SCFD2	206	Q8WU76
CQLLTRLSQTSPAGL	INTS5	671	Q6P9B9
PLSCSDISRSLIALL	OR8S1	186	Q8NH09
CGSLRPETIVLSALS	POLR2C	236	P19387
GLLDTTPIRGSCTTQ	SLX4	1471	Q8IY92
EVSALCRGQLPISVT	CLEC14A	211	Q86T13
LRCPTVTSAIGGLQL	TRAK1	896	Q9UPV9
TVLRCLGIPTRVVTN	TGM2	286	P21980
SAILPVLSRCSQLST	PRAMEF7	366	Q5VXH5
TVRLCEQLSTVIPNS	RPF1	156	Q9H9Y2
TCVSLTTQRLPVSRI	XCL1	31	P47992
TCVSLTTQRLPVSRI	XCL2	31	Q9UBD3
SPASQTSICIGILLR	UHRF1BP1L	851	A0JNW5
TCRPLQGTTLQRDVL	TMEM223	21	A0PJW6
SCLLSITDQVLLPSL	THOC2	481	Q8NI27
ISVSLPLSLSQSVCL	LINC00052	26	Q96N35
TSPECLQRTGISLNI	RALGAPA1	1691	Q6GYQ0
GRVLSCPATTLLNQL	RIPOR3	701	Q96MK2
TIILLILIPGTSNLC	SLC17A2	376	O00624
GCGVLSSTLRTLPTL	RNH1	101	P13489
PELTTCQELGRSLLL	SPTBN4	1996	Q9H254
ISCPLRGVLNVIITN	SLC9B1	56	Q4ZJI4
CPLLRTALSNITVET	PSME4	1406	Q14997
LITCNVILPLISRLS	SNX19	241	Q92543
CNLPLRTGSVDIIVT	THUMPD3	391	Q9BV44
SRVCTPTTGRAVLLT	THUMPD3	431	Q9BV44
SRTVGPTQRLLLCGT	YIPF3	266	Q9GZM5
LTSQTCEIRGSLPIL	WDCP	101	Q9H6R7
LLLLAVSGAQTTRPC	TSKU	6	Q8WUA8
RCESAGTSQITTLPL	ZFYVE26	2346	Q68DK2
SCSLSRGLQVLLTPV	TBK1	266	Q9UHD2
VSRSLLLTCLVPAAL	NAT8L	131	Q8N9F0
TTNPSSLLTQICGLL	GRIN2C	71	Q14957