Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A	2.52e-04	10	48	2	GO:1905394
Domain	FAM21	WASHC2C WASHC2A	5.93e-06	2	46	2	IPR027308
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	1.78e-05	3	46	2	IPR029341
Domain	CAP-ZIP_m	WASHC2C WASHC2A	1.78e-05	3	46	2	PF15255
Domain	ig	TYRO3 SIGLEC11 VSIG10 CNTFR	1.21e-03	190	46	4	PF00047
Domain	Immunoglobulin	TYRO3 SIGLEC11 VSIG10 CNTFR	1.21e-03	190	46	4	IPR013151
Domain	Ig-like_dom	TYRO3 CSF3R ICAM1 SIGLEC11 VSIG10 CNTFR	1.39e-03	503	46	6	IPR007110
Domain	IGc2	TYRO3 SIGLEC11 VSIG10 CNTFR	2.63e-03	235	46	4	SM00408
Domain	Ig_sub2	TYRO3 SIGLEC11 VSIG10 CNTFR	2.63e-03	235	46	4	IPR003598
Domain	IG	TYRO3 ICAM1 SIGLEC11 VSIG10 CNTFR	3.64e-03	421	46	5	SM00409
Domain	Ig_sub	TYRO3 ICAM1 SIGLEC11 VSIG10 CNTFR	3.64e-03	421	46	5	IPR003599
Domain	-	TYRO3 CSF3R ICAM1 SIGLEC11 VSIG10 CNTFR	5.47e-03	663	46	6	2.60.40.10
Domain	IG_LIKE	TYRO3 ICAM1 SIGLEC11 VSIG10 CNTFR	6.95e-03	491	46	5	PS50835
Domain	Ig-like_fold	TYRO3 CSF3R ICAM1 SIGLEC11 VSIG10 CNTFR	7.38e-03	706	46	6	IPR013783
Domain	fn3	TYRO3 CSF3R CNTFR	7.40e-03	162	46	3	PF00041
Domain	C1_1	PRKCG VAV2	8.69e-03	57	46	2	PF00130
Domain	FN3	TYRO3 CSF3R CNTFR	1.06e-02	185	46	3	SM00060
Domain	ZF_DAG_PE_1	PRKCG VAV2	1.09e-02	64	46	2	PS00479
Domain	ZF_DAG_PE_2	PRKCG VAV2	1.09e-02	64	46	2	PS50081
Domain	C1	PRKCG VAV2	1.12e-02	65	46	2	SM00109
Domain	Ig_I-set	TYRO3 SIGLEC11 VSIG10	1.14e-02	190	46	3	IPR013098
Domain	I-set	TYRO3 SIGLEC11 VSIG10	1.14e-02	190	46	3	PF07679
Domain	PE/DAG-bd	PRKCG VAV2	1.15e-02	66	46	2	IPR002219
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	1.94e-06	2	49	2	15847701
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	1.94e-06	2	49	2	20827171
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	1.94e-06	2	49	2	36717248
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	AATK SCAP RHBDF1 NRF1 NAV1 C15orf39 WASHC2A RNF43 MYORG PCNT	2.68e-06	1105	49	10	35748872
Pubmed	WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.	REC8 WDR62 PCNT	2.14e-05	38	49	3	34059773
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	USP6 ELOA2 WASHC2C WWP2 PRKCG PREPL BAG6	2.19e-05	608	49	7	16713569
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	5.42e-05	8	49	2	19922874
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASHC2C WASHC2A	1.27e-04	12	49	2	19922875
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASHC2C WASHC2A	1.27e-04	12	49	2	27390154
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	TYRO3 RHBDF1 KLHL15 BAG6 FBXL4	1.50e-04	359	49	5	35559673
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	WASHC2C ALMS1 NAV1 C15orf39 WASHC2A PCNT	1.72e-04	588	49	6	38580884
Pubmed	Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter.	VAV2 CNTFR	1.75e-04	14	49	2	2034277
Pubmed	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	MYORG CNTFR PCNT	1.86e-04	78	49	3	19204726
Pubmed	Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.	WASHC2C WASHC2A	2.02e-04	15	49	2	28892079
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AATK SCAP ALMS1 PCNT	2.88e-04	225	49	4	12168954
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ALMS1 NAV1 C15orf39 WDR62 PCNT	3.02e-04	418	49	5	34709266
Pubmed	Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.	ICAM1 PRKCG	3.27e-04	19	49	2	8432525
Pubmed	Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.	TYRO3 DHH	3.27e-04	19	49	2	30212841
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	WASHC2C WASHC2A	3.27e-04	19	49	2	25355947
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	WWP2 BAG6	4.41e-04	22	49	2	24981174
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	WASHC2C WASHC2A	4.83e-04	23	49	2	31748650
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	REC8 SCAP CHEK2 VSIG10 PREPL BAG6 FBXL4 PCNT	4.93e-04	1327	49	8	32694731
Pubmed	CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.	CHEK2 PCNT	6.67e-04	27	49	2	26158450
Pubmed	Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.	RHBDF1 WASHC2C ICAM1 WASHC2A	7.66e-04	292	49	4	12819125
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SCAP RHBDF1 WASHC2C WASHC2A ZRANB3 DSE PCNT	7.68e-04	1084	49	7	11544199
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	NRM C15orf39 PGAP4 BAG6	8.06e-04	296	49	4	34186245
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ALMS1 NAV1 NDUFA5 PREPL BAG6 WDR62 FBXL4 PCNT	1.08e-03	1496	49	8	32877691
Pubmed	Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis.	REC8 DHH	1.19e-03	36	49	2	38078651
Pubmed	A molecular genetic linkage map of mouse chromosome 7.	ICAM1 PRKCG	1.25e-03	37	49	2	1981054
Interaction	GOLGA1 interactions	SCAP WASHC2C ALMS1 NAV1 WASHC2A BAG6 PCNT	2.44e-07	183	48	7	int:GOLGA1
Interaction	AMOT interactions	WASHC2C ALMS1 WWP2 NAV1 WASHC2A RNF43 WDR62 PCNT	6.65e-07	312	48	8	int:AMOT
GeneFamily	WASH complex	WASHC2C WASHC2A	3.98e-05	6	30	2	1331
GeneFamily	Immunoglobulin like domain containing	TYRO3 ICAM1 VSIG10 CNTFR	2.78e-04	193	30	4	594
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TYRO3 AATK	2.00e-03	40	30	2	321
GeneFamily	Fibronectin type III domain containing	TYRO3 CSF3R CNTFR	2.32e-03	160	30	3	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TYRO3 SIGLEC11 VSIG10	2.36e-03	161	30	3	593

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETEPWAAAVPPEWVP	BAG6	1006	P46379
SWFEPITKTRPWREP	ALMS1	3986	Q8TCU4
PAEAQRAWWVLEPPG	BIRC7	221	Q96CA5
EEPTPAPWARLWALQ	CHEK2	86	O96017
ISLIPPEERWAWPEV	REC8	431	O95072
KPRVSPDWWEEPGRL	CFAP99	606	D6REC4
PYWVLEPVLEGWRPD	ELOA2	551	Q8IYF1
EWVPWEELPPLDQLF	NUDT15	121	Q9NV35
RLHIEWIPWPRPSSI	FAT2	1331	Q9NYQ8
DVWAAVPLPAFLPRW	GPR153	401	Q6NV75
PIWWPEDIPWANVRS	NRF1	231	Q16656
QPSWLVKDAPWDEVP	DSE	136	Q9UL01
WEPIPKGPVLWEARA	NRM	116	Q8IXM6
WIDWERLERLEIPPP	PRKCG	616	P05129
PIVWQATPRPWLVIT	PGAP4	91	Q9BRR3
SPEVLRKDWTLEPWP	PCNT	2226	O95613
RKDWTLEPWPSLPVT	PCNT	2231	O95613
IRPWWFPVQELRDPL	OOEP	36	A6NGQ2
VWWELEGPQVPLRPD	KLHL15	306	Q96M94
WGRCETWEKPILEPP	GPHB5	61	Q86YW7
PPAEVRWEILWSERP	FBXL4	166	Q9UKA2
VETEWPPRKLLLTPW	DHH	256	O43323
RLEVTWQTPSTWPDP	CNTFR	221	P26992
TWAQLEWVPEPPELG	CSF3R	541	Q99062
AILPPREWVEDTQLW	DNALI1	71	O14645
WTPERVELAPLPSWQ	ICAM1	111	P05362
PVPEVTWGPEDEELW	SCAP	611	Q12770
PVEWVRDTLPWPSAQ	NAV1	1791	Q8NEY1
PRNLTWIDSPAPERW	RTL1	376	A6NKG5
ARDELPDWNEVLPPW	VGF	516	O15240
WVPLRWIAPELVDEV	AATK	291	Q6ZMQ8
EDPHEWPEDITKWPI	RHBDF1	561	Q96CC6
IELKEPPAWPDYDVW	RNF43	186	Q68DV7
EWKLWEPLVEEPPAD	NDUFA5	96	Q16718
LWSNERPLPSRWPET	EXTL1	451	Q92935
PPEKLREWLETAGPW	C15orf39	786	Q6ZRI6
TTWERPLPPGWEKRT	WWP2	326	O00308
REEPAWPWKDAPIRT	REX1BD	26	Q96EN9
LVPASEPVWERPWSV	WASHC2C	11	Q9Y4E1
EVWLIDGLSPWDPPV	PREPL	276	Q4J6C6
RWSEPWVPVEALPPS	WDR62	1391	O43379
LAPASEPVWERPWSV	WASHC2A	11	Q641Q2
SSRPPPVVEWWFQAL	VSIG10	156	Q8N0Z9
VLELLRGDPESPWWE	VAV2	616	P52735
PAPSLRWWLGEELLE	SIGLEC11	481	Q96RL6
WIQVSWLARPLPPQE	USP6	921	P35125
EAVGPPEPVTIVWWR	TYRO3	161	Q06418
RYPWTEEIEKWIPEL	ZRANB3	91	Q5FWF4
RPWRDLPETGVWLPE	PSORS1C2	71	Q9UIG4
DPIVRPLWWIAPGDE	MYORG	631	Q6NSJ0