| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | protein kinase activity | 1.29e-04 | 600 | 51 | 8 | GO:0004672 | |
| GeneOntologyMolecularFunction | acyltransferase activity | 1.34e-04 | 775 | 51 | 9 | GO:0016746 | |
| GeneOntologyMolecularFunction | phosphotransferase activity, alcohol group as acceptor | 4.00e-04 | 709 | 51 | 8 | GO:0016773 | |
| GeneOntologyMolecularFunction | kinase activity | 6.56e-04 | 764 | 51 | 8 | GO:0016301 | |
| GeneOntologyMolecularFunction | ubiquitin-protein transferase activity | 1.25e-03 | 473 | 51 | 6 | GO:0004842 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein transferase activity | 1.87e-03 | 512 | 51 | 6 | GO:0019787 | |
| GeneOntologyMolecularFunction | aminoacyltransferase activity | 2.27e-03 | 532 | 51 | 6 | GO:0016755 | |
| GeneOntologyMolecularFunction | transferase activity, transferring phosphorus-containing groups | 2.43e-03 | 938 | 51 | 8 | GO:0016772 | |
| GeneOntologyMolecularFunction | ubiquitin protein ligase activity | 2.54e-03 | 372 | 51 | 5 | GO:0061630 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase activity | 3.40e-03 | 398 | 51 | 5 | GO:0061659 | |
| GeneOntologyMolecularFunction | magnesium ion binding | 3.62e-03 | 247 | 51 | 4 | GO:0000287 | |
| GeneOntologyMolecularFunction | molecular function inhibitor activity | 3.97e-03 | 596 | 51 | 6 | GO:0140678 | |
| GeneOntologyMolecularFunction | olfactory receptor activity | 4.76e-03 | 431 | 51 | 5 | GO:0004984 | |
| GeneOntologyMolecularFunction | enzyme inhibitor activity | 4.95e-03 | 435 | 51 | 5 | GO:0004857 | |
| GeneOntologyCellularComponent | Gtr1-Gtr2 GTPase complex | 3.49e-05 | 4 | 51 | 2 | GO:1990131 | |
| Domain | MKRN1_C | 6.47e-06 | 2 | 48 | 2 | PF15815 | |
| Domain | MKRN1_C | 6.47e-06 | 2 | 48 | 2 | IPR031644 | |
| Domain | RING | 1.20e-05 | 305 | 48 | 7 | SM00184 | |
| Domain | Znf_RING | 1.84e-05 | 326 | 48 | 7 | IPR001841 | |
| Domain | Gtr1_RagA | 3.87e-05 | 4 | 48 | 2 | PF04670 | |
| Domain | Gtr1_RagA | 3.87e-05 | 4 | 48 | 2 | IPR006762 | |
| Domain | ZF_RING_2 | 1.10e-04 | 298 | 48 | 6 | PS50089 | |
| Domain | Znf_RING/FYVE/PHD | 1.59e-04 | 459 | 48 | 7 | IPR013083 | |
| Domain | Tyr_kinase_rcpt_2_CS | 3.51e-04 | 11 | 48 | 2 | IPR002011 | |
| Domain | RECEPTOR_TYR_KIN_II | 4.20e-04 | 12 | 48 | 2 | PS00239 | |
| Domain | Znf_RING_CS | 8.07e-04 | 163 | 48 | 4 | IPR017907 | |
| Domain | ZF_RING_1 | 8.78e-04 | 291 | 48 | 5 | PS00518 | |
| Domain | - | 9.64e-04 | 18 | 48 | 2 | 3.30.470.20 | |
| Domain | - | 9.74e-04 | 449 | 48 | 6 | 3.30.40.10 | |
| Domain | Znf_C3HC4_RING-type | 9.85e-04 | 172 | 48 | 4 | IPR018957 | |
| Domain | PROTEIN_KINASE_ATP | 1.09e-03 | 459 | 48 | 6 | PS00107 | |
| Domain | TyrKc | 1.50e-03 | 88 | 48 | 3 | SM00219 | |
| Domain | Tyr_kinase_cat_dom | 1.50e-03 | 88 | 48 | 3 | IPR020635 | |
| Domain | Prot_kinase_dom | 1.51e-03 | 489 | 48 | 6 | IPR000719 | |
| Domain | PROTEIN_KINASE_DOM | 1.57e-03 | 493 | 48 | 6 | PS50011 | |
| Domain | PROTEIN_KINASE_TYR | 1.98e-03 | 97 | 48 | 3 | PS00109 | |
| Domain | Tyr_kinase_AS | 1.98e-03 | 97 | 48 | 3 | IPR008266 | |
| Domain | Kinase-like_dom | 2.53e-03 | 542 | 48 | 6 | IPR011009 | |
| Domain | zf-C3HC4 | 2.55e-03 | 223 | 48 | 4 | PF00097 | |
| Domain | ATP_grasp_subdomain_2 | 2.87e-03 | 31 | 48 | 2 | IPR013816 | |
| Domain | Pkinase_Tyr | 4.44e-03 | 129 | 48 | 3 | PF07714 | |
| Domain | - | 4.74e-03 | 40 | 48 | 2 | 4.10.1000.10 | |
| Domain | Ser-Thr/Tyr_kinase_cat_dom | 5.35e-03 | 138 | 48 | 3 | IPR001245 | |
| Domain | ZnF_C3H1 | 6.77e-03 | 48 | 48 | 2 | SM00356 | |
| Domain | zf-CCCH | 7.04e-03 | 49 | 48 | 2 | PF00642 | |
| Pathway | REACTOME_PTEN_REGULATION | 1.02e-05 | 98 | 42 | 5 | MM15348 | |
| Pathway | REACTOME_PTEN_REGULATION | 5.50e-05 | 139 | 42 | 5 | M27646 | |
| Pathway | REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK | 8.51e-05 | 29 | 42 | 3 | M19861 | |
| Pathway | REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK | 8.51e-05 | 29 | 42 | 3 | MM14980 | |
| Pathway | REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS | 9.40e-05 | 252 | 42 | 6 | MM15585 | |
| Pathway | REACTOME_MTOR_SIGNALLING | 2.42e-04 | 41 | 42 | 3 | M27000 | |
| Pathway | REACTOME_MTOR_SIGNALLING | 2.60e-04 | 42 | 42 | 3 | MM14638 | |
| Pathway | REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS | 3.05e-04 | 313 | 42 | 6 | M27867 | |
| Pathway | WP_FEMALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM | 7.71e-04 | 14 | 42 | 2 | M48059 | |
| Pathway | KEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY | 7.71e-04 | 14 | 42 | 2 | M47922 | |
| Pathway | KEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY | 7.71e-04 | 14 | 42 | 2 | M47918 | |
| Pubmed | USP14 KMT2C RBL2 MCM3AP COP1 APLP2 ZNF217 SPOP WNK1 SLC25A28 ITGB5 | 4.18e-06 | 1327 | 53 | 11 | 32694731 | |
| Pubmed | 6.83e-06 | 3 | 53 | 2 | 24095279 | ||
| Pubmed | Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. | 1.36e-05 | 4 | 53 | 2 | 18566305 | |
| Pubmed | Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. | 2.27e-05 | 5 | 53 | 2 | 24531128 | |
| Pubmed | SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. | 2.27e-05 | 5 | 53 | 2 | 22575674 | |
| Pubmed | A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome. | 2.27e-05 | 5 | 53 | 2 | 32612235 | |
| Pubmed | A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. | 3.40e-05 | 6 | 53 | 2 | 14660641 | |
| Pubmed | Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. | 3.40e-05 | 6 | 53 | 2 | 11073942 | |
| Pubmed | Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. | 3.40e-05 | 6 | 53 | 2 | 24529380 | |
| Pubmed | Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. | 3.40e-05 | 6 | 53 | 2 | 24081491 | |
| Pubmed | 3.40e-05 | 6 | 53 | 2 | 21441935 | ||
| Pubmed | The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. | 3.40e-05 | 6 | 53 | 2 | 18497260 | |
| Pubmed | 4.76e-05 | 7 | 53 | 2 | 25259925 | ||
| Pubmed | 6.34e-05 | 8 | 53 | 2 | 12724322 | ||
| Pubmed | 6.34e-05 | 8 | 53 | 2 | 31776466 | ||
| Pubmed | Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation. | 6.34e-05 | 8 | 53 | 2 | 26582740 | |
| Pubmed | 8.15e-05 | 9 | 53 | 2 | 24337580 | ||
| Pubmed | Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. | 1.02e-04 | 10 | 53 | 2 | 22424946 | |
| Pubmed | 1.49e-04 | 12 | 53 | 2 | 20381137 | ||
| Pubmed | SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. | 1.49e-04 | 12 | 53 | 2 | 25561175 | |
| Pubmed | XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6. | 1.49e-04 | 12 | 53 | 2 | 36346305 | |
| Pubmed | Different evolutionary processes shaped the mouse and human olfactory receptor gene families. | 1.69e-04 | 340 | 53 | 5 | 11875048 | |
| Pubmed | 1.69e-04 | 340 | 53 | 5 | 11802173 | ||
| Pubmed | 1.76e-04 | 13 | 53 | 2 | 19859091 | ||
| Pubmed | Modelling bladder cancer in mice: opportunities and challenges. | 1.76e-04 | 13 | 53 | 2 | 25533675 | |
| Pubmed | 1.76e-04 | 343 | 53 | 5 | 32295537 | ||
| Pubmed | 1.84e-04 | 346 | 53 | 5 | 14611657 | ||
| Pubmed | TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. | 2.05e-04 | 14 | 53 | 2 | 28716898 | |
| Pubmed | The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. | 2.35e-04 | 197 | 53 | 4 | 20811636 | |
| Pubmed | E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. | 2.36e-04 | 15 | 53 | 2 | 18276110 | |
| Pubmed | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. | 2.57e-04 | 372 | 53 | 5 | 22939624 | |
| Pubmed | 2.82e-04 | 83 | 53 | 3 | 11114734 | ||
| Pubmed | 3.81e-04 | 92 | 53 | 3 | 20368287 | ||
| Pubmed | 3.83e-04 | 19 | 53 | 2 | 15529118 | ||
| Pubmed | Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. | 4.43e-04 | 910 | 53 | 7 | 36736316 | |
| Pubmed | 5.16e-04 | 22 | 53 | 2 | 27335464 | ||
| Pubmed | 5.16e-04 | 22 | 53 | 2 | 27824289 | ||
| Pubmed | Functional genomics identifies therapeutic targets for MYC-driven cancer. | 5.31e-04 | 103 | 53 | 3 | 22623531 | |
| Pubmed | Murine chromosomal location of five bHLH-Zip transcription factor genes. | 6.16e-04 | 24 | 53 | 2 | 8530024 | |
| Pubmed | 8.40e-04 | 28 | 53 | 2 | 34163012 | ||
| Pubmed | 8.62e-04 | 486 | 53 | 5 | 20936779 | ||
| Pubmed | The functional interactome landscape of the human histone deacetylase family. | 9.93e-04 | 289 | 53 | 4 | 23752268 | |
| Pubmed | RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. | 1.17e-03 | 33 | 53 | 2 | 23751493 | |
| Pubmed | 1.24e-03 | 1084 | 53 | 7 | 11544199 | ||
| Pubmed | A probabilistic classifier for olfactory receptor pseudogenes. | 1.31e-03 | 35 | 53 | 2 | 16939646 | |
| Pubmed | A dual-activity topoisomerase complex regulates mRNA translation and turnover. | 1.38e-03 | 1105 | 53 | 7 | 35748872 | |
| Pubmed | 1.43e-03 | 1440 | 53 | 8 | 30833792 | ||
| Interaction | CCNE1 interactions | 8.08e-06 | 121 | 46 | 5 | int:CCNE1 | |
| Interaction | MDM2 interactions | 1.49e-05 | 658 | 46 | 9 | int:MDM2 | |
| Interaction | UBE2E1 interactions | 3.51e-05 | 164 | 46 | 5 | int:UBE2E1 | |
| GeneFamily | Ring finger proteins | 1.35e-03 | 275 | 32 | 4 | 58 | |
| GeneFamily | Receptor Tyrosine Kinases|CD molecules | 2.27e-03 | 40 | 32 | 2 | 321 | |
| Coexpression | LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP | 1.22e-05 | 74 | 50 | 4 | M515 | |
| ToppCell | droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 3.04e-06 | 193 | 52 | 5 | fa8bcf2a5ab7b08fae98a1466a936995142b4309 | |
| Drug | Niacin [59-67-6]; Up 200; 32.4uM; MCF7; HT_HG-U133A | 5.52e-06 | 196 | 52 | 6 | 5301_UP | |
| Drug | lonidamine | 1.06e-05 | 19 | 52 | 3 | ctd:C016371 | |
| Disease | follicular lymphoma (implicated_via_orthology) | 3.04e-05 | 5 | 52 | 2 | DOID:0050873 (implicated_via_orthology) | |
| Disease | Adenocarcinoma of lung (disorder) | 3.14e-05 | 206 | 52 | 5 | C0152013 | |
| Disease | pulse pressure measurement, migraine without aura, susceptibility to, 4 | 1.09e-04 | 9 | 52 | 2 | EFO_0005763, MONDO_0011847 | |
| Disease | colorectal cancer (is_marker_for) | 1.71e-04 | 157 | 52 | 4 | DOID:9256 (is_marker_for) | |
| Disease | squamous cell carcinoma (is_implicated_in) | 4.58e-04 | 18 | 52 | 2 | DOID:1749 (is_implicated_in) | |
| Disease | lung adenocarcinoma (is_marker_for) | 4.60e-04 | 85 | 52 | 3 | DOID:3910 (is_marker_for) | |
| Disease | Carcinoma, Granular Cell | 1.14e-03 | 116 | 52 | 3 | C0205644 | |
| Disease | Adenocarcinoma, Tubular | 1.14e-03 | 116 | 52 | 3 | C0205645 | |
| Disease | Adenocarcinoma, Oxyphilic | 1.14e-03 | 116 | 52 | 3 | C0205642 | |
| Disease | Carcinoma, Cribriform | 1.14e-03 | 116 | 52 | 3 | C0205643 | |
| Disease | Adenocarcinoma, Basal Cell | 1.14e-03 | 116 | 52 | 3 | C0205641 | |
| Disease | Adenocarcinoma | 1.14e-03 | 116 | 52 | 3 | C0001418 | |
| Disease | Colorectal Carcinoma | 1.43e-03 | 702 | 52 | 6 | C0009402 | |
| Disease | Large cell carcinoma of lung | 1.46e-03 | 32 | 52 | 2 | C0345958 | |
| Disease | ovarian neoplasm | 1.72e-03 | 134 | 52 | 3 | C0919267 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| ACPCKMECYMDSEEF | 311 | Q6PI77 | |
| LYRCCMLFVDDMAEP | 321 | Q8N163 | |
| CPICFDMIEEAYMTK | 136 | Q8NHY2 | |
| LMHYCEACTAPKMPE | 2031 | Q9HCE0 | |
| MCKDVCEAMEYLESK | 501 | Q06187 | |
| CVQDDPLCMITDYME | 691 | Q08345 | |
| MTECTTIEHPFCMYD | 366 | Q9UDR5 | |
| FFCDVPAMVTLACMD | 176 | Q8NG85 | |
| CFEFSIIQCPELMMD | 871 | Q08999 | |
| ESEDYCMAVCKAMIP | 351 | Q06481 | |
| VADIGFDCSMCRPYM | 1126 | Q8NEZ4 | |
| FVEFDMKPVCKRCYE | 296 | Q7Z4I7 | |
| TCLDMCPEKERYMRE | 636 | O60318 | |
| FFCDVPAMVTLACMD | 176 | Q8NGY9 | |
| PDITECKEEDIMCMY | 66 | O96000 | |
| EHCVMYPIDCVKTRM | 86 | Q96A46 | |
| VMCRFYKVMDALEPA | 26 | P51617 | |
| TMMTCAYEEPTCEVG | 661 | P19367 | |
| TAKDCVMMFTYVELP | 686 | P18084 | |
| AIMAMDCYVAICKPL | 116 | Q8NH89 | |
| EEYCMEVLCKEMVTF | 306 | P34913 | |
| LVQSMMDCLYAKCIP | 86 | Q9Y324 | |
| AITACVEPMSCYMEH | 856 | Q5TEA3 | |
| AMVKLYCPKCMDVYT | 131 | P67870 | |
| LMKPYFITCREAMEA | 376 | Q6ZN54 | |
| CRSPYEMFGDEEVMC | 176 | Q03591 | |
| TPVDMQTYELCCDMI | 276 | Q9NQL2 | |
| YTMVCPPFNETECKM | 2231 | Q3ZCN5 | |
| YTCLATVFPMDKMIA | 256 | Q8NGL9 | |
| SKDMVCGICMEVVYE | 276 | Q9UHC7 | |
| MDSTRHEPMYCFLCV | 81 | Q8NH67 | |
| KDYIFEVMDCSMPLI | 381 | Q92777 | |
| MCPEHETERINMYCE | 211 | Q9NQ86 | |
| PVDMQSYELCCDMID | 276 | Q9HB90 | |
| YCVCGMQEMLDSVPE | 131 | Q15831 | |
| CMFCLYSFMPLVIKV | 271 | Q8IXU6 | |
| RLPKYSCQFIEMCLM | 881 | P53396 | |
| MVMHSEDEPYKCKFC | 1 | Q6ZTB9 | |
| MYAQCMEVGKEKCLP | 221 | O60704 | |
| EAVDKCPMCYTVITF | 476 | P98170 | |
| GMDKVCGICMEVVYE | 306 | Q13064 | |
| CDLMHDPECIYKAMN | 51 | Q9UHP6 | |
| DPECIYKAMNIGCME | 56 | Q9UHP6 | |
| KCCPFMESMLRYEVY | 596 | Q6ZVD7 | |
| VEPEVFKEMMCFIYT | 246 | O43791 | |
| MYFIMDELVCVCDLE | 381 | P08922 | |
| MFECDVCHKFMKTPE | 1046 | Q17R98 | |
| MIYKCPMCREFFSER | 1 | Q8N3J9 | |
| CQDCMKMYGDLDVLF | 316 | Q8N806 | |
| VIQIEGYMPLDCMFC | 56 | O75362 | |
| PTCMKMDEVLYSIAE | 36 | P83876 | |
| CMLEMATSEYPYSEC | 411 | Q9H4A3 | |
| DVKFPLMLDMYELCT | 346 | P54578 | |
| PKDYMMESVLVTLFC | 186 | A0A1B0GWB2 | |
| FNISCLCYDPEMKML | 111 | Q6ZQQ6 |