Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein kinase activity

STK11 DDR1 HK1 CSNK2B BTK IRAK1 ROS1 WNK1

1.29e-04600518GO:0004672
GeneOntologyMolecularFunctionacyltransferase activity

MKRN3 KMT2C ACLY MKRN1 MCM3AP COP1 XIAP TRIM36 UBR7

1.34e-04775519GO:0016746
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

STK11 DDR1 HK1 CSNK2B BTK IRAK1 ROS1 WNK1

4.00e-04709518GO:0016773
GeneOntologyMolecularFunctionkinase activity

STK11 DDR1 HK1 CSNK2B BTK IRAK1 ROS1 WNK1

6.56e-04764518GO:0016301
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

MKRN3 MKRN1 COP1 XIAP TRIM36 UBR7

1.25e-03473516GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

MKRN3 MKRN1 COP1 XIAP TRIM36 UBR7

1.87e-03512516GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

MKRN3 MKRN1 COP1 XIAP TRIM36 UBR7

2.27e-03532516GO:0016755
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

STK11 DDR1 HK1 CSNK2B BTK IRAK1 ROS1 WNK1

2.43e-03938518GO:0016772
GeneOntologyMolecularFunctionubiquitin protein ligase activity

MKRN3 MKRN1 COP1 XIAP UBR7

2.54e-03372515GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

MKRN3 MKRN1 COP1 XIAP UBR7

3.40e-03398515GO:0061659
GeneOntologyMolecularFunctionmagnesium ion binding

EPHX2 STK11 WNK1 RRAGC

3.62e-03247514GO:0000287
GeneOntologyMolecularFunctionmolecular function inhibitor activity

USP14 XIAP CCAR2 APLP2 SPOP WNK1

3.97e-03596516GO:0140678
GeneOntologyMolecularFunctionolfactory receptor activity

OR52I2 OR2L8 OR2L3 OR4C16 OR5AK3P

4.76e-03431515GO:0004984
GeneOntologyMolecularFunctionenzyme inhibitor activity

USP14 XIAP CCAR2 APLP2 WNK1

4.95e-03435515GO:0004857
GeneOntologyCellularComponentGtr1-Gtr2 GTPase complex

RRAGD RRAGC

3.49e-054512GO:1990131
DomainMKRN1_C

MKRN3 MKRN1

6.47e-062482PF15815
DomainMKRN1_C

MKRN3 MKRN1

6.47e-062482IPR031644
DomainRING

MKRN3 KMT2C MKRN1 DEF8 COP1 XIAP TRIM36

1.20e-05305487SM00184
DomainZnf_RING

MKRN3 KMT2C MKRN1 DEF8 COP1 XIAP TRIM36

1.84e-05326487IPR001841
DomainGtr1_RagA

RRAGD RRAGC

3.87e-054482PF04670
DomainGtr1_RagA

RRAGD RRAGC

3.87e-054482IPR006762
DomainZF_RING_2

MKRN3 KMT2C MKRN1 COP1 XIAP TRIM36

1.10e-04298486PS50089
DomainZnf_RING/FYVE/PHD

MKRN3 KMT2C MKRN1 COP1 XIAP TRIM36 UBR7

1.59e-04459487IPR013083
DomainTyr_kinase_rcpt_2_CS

DDR1 ROS1

3.51e-0411482IPR002011
DomainRECEPTOR_TYR_KIN_II

DDR1 ROS1

4.20e-0412482PS00239
DomainZnf_RING_CS

MKRN3 MKRN1 COP1 TRIM36

8.07e-04163484IPR017907
DomainZF_RING_1

MKRN3 MKRN1 COP1 XIAP TRIM36

8.78e-04291485PS00518
Domain-

ACLY SYN2

9.64e-04184823.30.470.20
Domain-

MKRN3 KMT2C MKRN1 COP1 TRIM36 UBR7

9.74e-044494863.30.40.10
DomainZnf_C3HC4_RING-type

MKRN3 MKRN1 COP1 TRIM36

9.85e-04172484IPR018957
DomainPROTEIN_KINASE_ATP

STK11 DDR1 BTK IRAK1 ROS1 WNK1

1.09e-03459486PS00107
DomainTyrKc

DDR1 BTK ROS1

1.50e-0388483SM00219
DomainTyr_kinase_cat_dom

DDR1 BTK ROS1

1.50e-0388483IPR020635
DomainProt_kinase_dom

STK11 DDR1 BTK IRAK1 ROS1 WNK1

1.51e-03489486IPR000719
DomainPROTEIN_KINASE_DOM

STK11 DDR1 BTK IRAK1 ROS1 WNK1

1.57e-03493486PS50011
DomainPROTEIN_KINASE_TYR

DDR1 BTK ROS1

1.98e-0397483PS00109
DomainTyr_kinase_AS

DDR1 BTK ROS1

1.98e-0397483IPR008266
DomainKinase-like_dom

STK11 DDR1 BTK IRAK1 ROS1 WNK1

2.53e-03542486IPR011009
Domainzf-C3HC4

MKRN3 MKRN1 COP1 TRIM36

2.55e-03223484PF00097
DomainATP_grasp_subdomain_2

ACLY SYN2

2.87e-0331482IPR013816
DomainPkinase_Tyr

DDR1 BTK ROS1

4.44e-03129483PF07714
Domain-

MKRN3 MKRN1

4.74e-03404824.10.1000.10
DomainSer-Thr/Tyr_kinase_cat_dom

DDR1 BTK ROS1

5.35e-03138483IPR001245
DomainZnF_C3H1

MKRN3 MKRN1

6.77e-0348482SM00356
Domainzf-CCCH

MKRN3 MKRN1

7.04e-0349482PF00642
PathwayREACTOME_PTEN_REGULATION

RRAGD CSNK2B MKRN1 XIAP RRAGC

1.02e-0598425MM15348
PathwayREACTOME_PTEN_REGULATION

RRAGD CSNK2B MKRN1 XIAP RRAGC

5.50e-05139425M27646
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

STK11 RRAGD RRAGC

8.51e-0529423M19861
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

STK11 RRAGD RRAGC

8.51e-0529423MM14980
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

RRAGD CSNK2B MKRN1 IRAK1 XIAP RRAGC

9.40e-05252426MM15585
PathwayREACTOME_MTOR_SIGNALLING

STK11 RRAGD RRAGC

2.42e-0441423M27000
PathwayREACTOME_MTOR_SIGNALLING

STK11 RRAGD RRAGC

2.60e-0442423MM14638
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

RRAGD CSNK2B MKRN1 IRAK1 XIAP RRAGC

3.05e-04313426M27867
PathwayWP_FEMALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM

STK11 ACLY

7.71e-0414422M48059
PathwayKEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY

RRAGD RRAGC

7.71e-0414422M47922
PathwayKEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY

RRAGD RRAGC

7.71e-0414422M47918
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

USP14 KMT2C RBL2 MCM3AP COP1 APLP2 ZNF217 SPOP WNK1 SLC25A28 ITGB5

4.18e-061327531132694731
Pubmed

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

RRAGD RRAGC

6.83e-06353224095279
Pubmed

Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.

IRAK1 ROS1

1.36e-05453218566305
Pubmed

Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma.

STK11 RBL2

2.27e-05553224531128
Pubmed

SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.

RRAGD RRAGC

2.27e-05553222575674
Pubmed

A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.

RRAGD RRAGC

2.27e-05553232612235
Pubmed

A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.

RRAGD RRAGC

3.40e-05653214660641
Pubmed

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.

RRAGD RRAGC

3.40e-05653211073942
Pubmed

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

RRAGD RRAGC

3.40e-05653224529380
Pubmed

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.

RRAGD RRAGC

3.40e-05653224081491
Pubmed

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk.

BTK IRAK1

3.40e-05653221441935
Pubmed

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

RRAGD RRAGC

3.40e-05653218497260
Pubmed

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

RRAGD RRAGC

4.76e-05753225259925
Pubmed

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

BTK IRAK1

6.34e-05853212724322
Pubmed

CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling.

IRAK1 SPOP

6.34e-05853231776466
Pubmed

Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.

RRAGD RRAGC

6.34e-05853226582740
Pubmed

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

RRAGD RRAGC

8.15e-05953224337580
Pubmed

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

RRAGD RRAGC

1.02e-041053222424946
Pubmed

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

RRAGD RRAGC

1.49e-041253220381137
Pubmed

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

RRAGD RRAGC

1.49e-041253225561175
Pubmed

XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.

ACLY XIAP

1.49e-041253236346305
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR52I2 OR2L8 OR2L3 OR4C16 OR5AK3P

1.69e-0434053511875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR52I2 OR2L8 OR2L3 OR4C16 OR5AK3P

1.69e-0434053511802173
Pubmed

Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country.

BTK XIAP

1.76e-041353219859091
Pubmed

Modelling bladder cancer in mice: opportunities and challenges.

STK11 RBL2

1.76e-041353225533675
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR52I2 OR2L8 OR2L3 OR4C16 OR5AK3P

1.76e-0434353532295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR52I2 OR2L8 OR2L3 OR4C16 OR5AK3P

1.84e-0434653514611657
Pubmed

TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.

RRAGD RRAGC

2.05e-041453228716898
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

AASS ACLY CSNK2B MCM3AP

2.35e-0419753420811636
Pubmed

E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.

CSNK2B MCM3AP

2.36e-041553218276110
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

STK11 DDR1 BTK DNAAF9 TRIM36

2.57e-0437253522939624
Pubmed

The protein tyrosine kinase family of the human genome.

DDR1 BTK ROS1

2.82e-048353311114734
Pubmed

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.

STK11 TXNL4A CSNK2B

3.81e-049253320368287
Pubmed

Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.

SYN2 APLP2

3.83e-041953215529118
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

STK11 DDR1 RBL2 CSNK2B BTK IRAK1 LIMS2

4.43e-0491053736736316
Pubmed

E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors.

COP1 TRIM36

5.16e-042253227335464
Pubmed

PEG3 binds to H19-ICR as a transcriptional repressor.

SLC35F2 APLP2

5.16e-042253227824289
Pubmed

Functional genomics identifies therapeutic targets for MYC-driven cancer.

BTK WNK1 ITGB5

5.31e-0410353322623531
Pubmed

Murine chromosomal location of five bHLH-Zip transcription factor genes.

DDR1 BTK

6.16e-04245328530024
Pubmed

SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.

CSNK2B CCAR2

8.40e-042853234163012
Pubmed

A human MAP kinase interactome.

KMT2C BTK MCM3AP APLP2 WNK1

8.62e-0448653520936779
Pubmed

The functional interactome landscape of the human histone deacetylase family.

ZNF827 CSNK2B CCAR2 ZNF217

9.93e-0428953423752268
Pubmed

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

USP14 CSNK2B

1.17e-033353223751493
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

STK11 KMT2C RRAGD DEF8 XIAP SLC35F2 WNK1

1.24e-03108453711544199
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR2L8 OR4C16

1.31e-033553216939646
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TPST2 KMT2C ZNF827 MCM3AP IRAK1 WNK1 ITGB5

1.38e-03110553735748872
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

USP14 HK1 AASS CSNK2B IRAK1 CCAR2 SLC25A28 NDUFB10

1.43e-03144053830833792
InteractionCCNE1 interactions

STK11 RBL2 CSNK2B SPOP TRIM36

8.08e-06121465int:CCNE1
InteractionMDM2 interactions

MKRN3 USP14 STK11 RBL2 CSNK2B BTK COP1 XIAP CCAR2

1.49e-05658469int:MDM2
InteractionUBE2E1 interactions

MKRN3 ZNF827 COP1 XIAP UBR7

3.51e-05164465int:UBE2E1
GeneFamilyRing finger proteins

MKRN3 MKRN1 COP1 TRIM36

1.35e-0327532458
GeneFamilyReceptor Tyrosine Kinases|CD molecules

DDR1 ROS1

2.27e-0340322321
CoexpressionLEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP

DDR1 BTK WNK1 ITGB5

1.22e-0574504M515
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 HK1 RRAGD WNK1 ITGB5

3.04e-06193525fa8bcf2a5ab7b08fae98a1466a936995142b4309
DrugNiacin [59-67-6]; Up 200; 32.4uM; MCF7; HT_HG-U133A

FCF1 STK11 TPST2 TXNL4A APLP2 WNK1

5.52e-061965265301_UP
Druglonidamine

STK11 HK1 XIAP

1.06e-0519523ctd:C016371
Diseasefollicular lymphoma (implicated_via_orthology)

RRAGD RRAGC

3.04e-055522DOID:0050873 (implicated_via_orthology)
DiseaseAdenocarcinoma of lung (disorder)

STK11 HK1 IRAK1 ROS1 WNK1

3.14e-05206525C0152013
Diseasepulse pressure measurement, migraine without aura, susceptibility to, 4

SPOP ITGB5

1.09e-049522EFO_0005763, MONDO_0011847
Diseasecolorectal cancer (is_marker_for)

DDR1 BTK XIAP SPOP

1.71e-04157524DOID:9256 (is_marker_for)
Diseasesquamous cell carcinoma (is_implicated_in)

KMT2C IRAK1

4.58e-0418522DOID:1749 (is_implicated_in)
Diseaselung adenocarcinoma (is_marker_for)

KMT2C BTK SPOP

4.60e-0485523DOID:3910 (is_marker_for)
DiseaseCarcinoma, Granular Cell

STK11 DDR1 KMT2C

1.14e-03116523C0205644
DiseaseAdenocarcinoma, Tubular

STK11 DDR1 KMT2C

1.14e-03116523C0205645
DiseaseAdenocarcinoma, Oxyphilic

STK11 DDR1 KMT2C

1.14e-03116523C0205642
DiseaseCarcinoma, Cribriform

STK11 DDR1 KMT2C

1.14e-03116523C0205643
DiseaseAdenocarcinoma, Basal Cell

STK11 DDR1 KMT2C

1.14e-03116523C0205641
DiseaseAdenocarcinoma

STK11 DDR1 KMT2C

1.14e-03116523C0001418
DiseaseColorectal Carcinoma

MKRN3 STK11 KMT2C MCM3AP ZNF217 WNK1

1.43e-03702526C0009402
DiseaseLarge cell carcinoma of lung

BTK ROS1

1.46e-0332522C0345958
Diseaseovarian neoplasm

STK11 RBL2 XIAP

1.72e-03134523C0919267

Protein segments in the cluster

PeptideGeneStartEntry
ACPCKMECYMDSEEF

BHLHB9

311

Q6PI77
LYRCCMLFVDDMAEP

CCAR2

321

Q8N163
CPICFDMIEEAYMTK

COP1

136

Q8NHY2
LMHYCEACTAPKMPE

EPG5

2031

Q9HCE0
MCKDVCEAMEYLESK

BTK

501

Q06187
CVQDDPLCMITDYME

DDR1

691

Q08345
MTECTTIEHPFCMYD

AASS

366

Q9UDR5
FFCDVPAMVTLACMD

OR2L3

176

Q8NG85
CFEFSIIQCPELMMD

RBL2

871

Q08999
ESEDYCMAVCKAMIP

APLP2

351

Q06481
VADIGFDCSMCRPYM

KMT2C

1126

Q8NEZ4
FVEFDMKPVCKRCYE

LIMS2

296

Q7Z4I7
TCLDMCPEKERYMRE

MCM3AP

636

O60318
FFCDVPAMVTLACMD

OR2L8

176

Q8NGY9
PDITECKEEDIMCMY

NDUFB10

66

O96000
EHCVMYPIDCVKTRM

SLC25A28

86

Q96A46
VMCRFYKVMDALEPA

IRAK1

26

P51617
TMMTCAYEEPTCEVG

HK1

661

P19367
TAKDCVMMFTYVELP

ITGB5

686

P18084
AIMAMDCYVAICKPL

OR5AK3P

116

Q8NH89
EEYCMEVLCKEMVTF

EPHX2

306

P34913
LVQSMMDCLYAKCIP

FCF1

86

Q9Y324
AITACVEPMSCYMEH

DNAAF9

856

Q5TEA3
AMVKLYCPKCMDVYT

CSNK2B

131

P67870
LMKPYFITCREAMEA

DEF8

376

Q6ZN54
CRSPYEMFGDEEVMC

CFHR1

176

Q03591
TPVDMQTYELCCDMI

RRAGD

276

Q9NQL2
YTMVCPPFNETECKM

OTOGL

2231

Q3ZCN5
YTCLATVFPMDKMIA

OR4C16

256

Q8NGL9
SKDMVCGICMEVVYE

MKRN1

276

Q9UHC7
MDSTRHEPMYCFLCV

OR52I2

81

Q8NH67
KDYIFEVMDCSMPLI

SYN2

381

Q92777
MCPEHETERINMYCE

TRIM36

211

Q9NQ86
PVDMQSYELCCDMID

RRAGC

276

Q9HB90
YCVCGMQEMLDSVPE

STK11

131

Q15831
CMFCLYSFMPLVIKV

SLC35F2

271

Q8IXU6
RLPKYSCQFIEMCLM

ACLY

881

P53396
MVMHSEDEPYKCKFC

ZNF833P

1

Q6ZTB9
MYAQCMEVGKEKCLP

TPST2

221

O60704
EAVDKCPMCYTVITF

XIAP

476

P98170
GMDKVCGICMEVVYE

MKRN3

306

Q13064
CDLMHDPECIYKAMN

RSPH14

51

Q9UHP6
DPECIYKAMNIGCME

RSPH14

56

Q9UHP6
KCCPFMESMLRYEVY

STOX1

596

Q6ZVD7
VEPEVFKEMMCFIYT

SPOP

246

O43791
MYFIMDELVCVCDLE

ROS1

381

P08922
MFECDVCHKFMKTPE

ZNF827

1046

Q17R98
MIYKCPMCREFFSER

ZNF664

1

Q8N3J9
CQDCMKMYGDLDVLF

UBR7

316

Q8N806
VIQIEGYMPLDCMFC

ZNF217

56

O75362
PTCMKMDEVLYSIAE

TXNL4A

36

P83876
CMLEMATSEYPYSEC

WNK1

411

Q9H4A3
DVKFPLMLDMYELCT

USP14

346

P54578
PKDYMMESVLVTLFC

PRRT1B

186

A0A1B0GWB2
FNISCLCYDPEMKML

WDR87

111

Q6ZQQ6