Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen synthase activity, transferring glucose-1-phosphate	GYS1 GYS2	4.75e-06	2	44	2	GO:0061547
GeneOntologyMolecularFunction	parathyroid hormone receptor activity	PTH1R PTH2R	4.75e-06	2	44	2	GO:0004991
GeneOntologyMolecularFunction	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	GYS1 GYS2	1.42e-05	3	44	2	GO:0004373
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	1.42e-05	3	44	2	GO:0005220
GeneOntologyMolecularFunction	UDP-glucosyltransferase activity	GYS1 GYS2	3.64e-04	13	44	2	GO:0035251
GeneOntologyMolecularFunction	guanyl ribonucleotide binding	SEPTIN11 SEPTIN8 MTG1 PDE10A SEPTIN10 SEPTIN6	3.80e-04	439	44	6	GO:0032561
GeneOntologyMolecularFunction	guanyl nucleotide binding	SEPTIN11 SEPTIN8 MTG1 PDE10A SEPTIN10 SEPTIN6	3.80e-04	439	44	6	GO:0019001
GeneOntologyMolecularFunction	D-glucose binding	GYS1 GYS2	4.25e-04	14	44	2	GO:0005536
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 ITPR2	4.25e-04	14	44	2	GO:0070679
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	ITPR1 ITPR2	7.10e-04	18	44	2	GO:0015278
GeneOntologyMolecularFunction	GTPase activity	SEPTIN11 SEPTIN8 MTG1 SEPTIN10 SEPTIN6	8.87e-04	341	44	5	GO:0003924
GeneOntologyMolecularFunction	glucosyltransferase activity	GYS1 GYS2	1.07e-03	22	44	2	GO:0046527
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE10A PDE6B	1.07e-03	22	44	2	GO:0004115
GeneOntologyMolecularFunction	hexosyltransferase activity	FUT4 ALG9 GYS1 GYS2	1.18e-03	211	44	4	GO:0016758
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE10A PDE6B	1.27e-03	24	44	2	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE10A PDE6B	1.38e-03	25	44	2	GO:0004114
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	SEPTIN11 SEPTIN8 MTG1 ABCC12 SEPTIN10 ATAD2 SEPTIN6	1.41e-03	775	44	7	GO:0017111
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PALD1 PDE10A SBF1 PDE6B TPTE2	1.54e-03	386	44	5	GO:0042578
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE10A PDE6B	1.61e-03	27	44	2	GO:0004112
GeneOntologyMolecularFunction	GTP binding	SEPTIN11 SEPTIN8 MTG1 SEPTIN10 SEPTIN6	1.74e-03	397	44	5	GO:0005525
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	ITPR1 ITPR2	2.12e-03	31	44	2	GO:0099604
GeneOntologyMolecularFunction	pyrophosphatase activity	SEPTIN11 SEPTIN8 MTG1 ABCC12 SEPTIN10 ATAD2 SEPTIN6	2.22e-03	839	44	7	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	SEPTIN11 SEPTIN8 MTG1 ABCC12 SEPTIN10 ATAD2 SEPTIN6	2.24e-03	840	44	7	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	SEPTIN11 SEPTIN8 MTG1 ABCC12 SEPTIN10 ATAD2 SEPTIN6	2.24e-03	840	44	7	GO:0016818
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	ITPR1 ITPR2	2.40e-03	33	44	2	GO:0005217
GeneOntologyMolecularFunction	glycosyltransferase activity	FUT4 ALG9 GYS1 GYS2	3.66e-03	288	44	4	GO:0016757
GeneOntologyMolecularFunction	peptide hormone binding	PTH1R PTH2R	6.54e-03	55	44	2	GO:0017046
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	PALD1 SBF1 TPTE2	8.31e-03	189	44	3	GO:0004721
GeneOntologyMolecularFunction	molecular adaptor activity	SEPTIN11 SEPTIN8 ZSWIM8 KDM5B ZNF28 SEPTIN10 PPRC1 SEPTIN6	8.76e-03	1356	44	8	GO:0060090
GeneOntologyCellularComponent	septin complex	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.68e-08	14	44	4	GO:0031105
GeneOntologyCellularComponent	septin ring	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.68e-08	14	44	4	GO:0005940
GeneOntologyCellularComponent	septin cytoskeleton	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	3.05e-08	16	44	4	GO:0032156
GeneOntologyCellularComponent	cell division site	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	2.40e-05	80	44	4	GO:0032153
GeneOntologyCellularComponent	cell cortex	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6 GYS2 ITPR2	1.20e-04	371	44	6	GO:0005938
GeneOntologyCellularComponent	sperm annulus	SEPTIN10 SEPTIN6	1.54e-04	9	44	2	GO:0097227
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2	1.54e-04	9	44	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2	2.35e-04	11	44	2	GO:0031094
Domain	Septin	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.89e-08	13	44	4	PF00735
Domain	G_SEPTIN_dom	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.89e-08	13	44	4	IPR030379
Domain	G_SEPTIN	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.89e-08	13	44	4	PS51719
Domain	Septin	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	2.64e-08	14	44	4	IPR016491
Domain	Glycogen_synth	GYS1 GYS2	5.42e-06	2	44	2	IPR008631
Domain	Glycogen_syn	GYS1 GYS2	5.42e-06	2	44	2	PF05693
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	1.62e-05	3	44	2	IPR000493
Domain	RIH_assoc	ITPR1 ITPR2	8.09e-05	6	44	2	PF08454
Domain	RIH_assoc-dom	ITPR1 ITPR2	8.09e-05	6	44	2	IPR013662
Domain	RYDR_ITPR	ITPR1 ITPR2	8.09e-05	6	44	2	PF01365
Domain	RIH_dom	ITPR1 ITPR2	8.09e-05	6	44	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	8.09e-05	6	44	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	8.09e-05	6	44	2	IPR015925
Domain	Ins145_P3_rec	ITPR1 ITPR2	8.09e-05	6	44	2	PF08709
Domain	-	ITPR1 ITPR2	8.09e-05	6	44	2	1.25.10.30
Domain	GAF	PDE10A PDE6B	1.13e-04	7	44	2	PF01590
Domain	GAF	PDE10A PDE6B	1.51e-04	8	44	2	IPR003018
Domain	GAF	PDE10A PDE6B	1.51e-04	8	44	2	SM00065
Domain	-	PDE10A PDE6B	1.93e-04	9	44	2	3.30.450.40
Domain	GAF_dom-like	PDE10A PDE6B	1.93e-04	9	44	2	IPR029016
Domain	MIR	ITPR1 ITPR2	2.41e-04	10	44	2	PS50919
Domain	MIR	ITPR1 ITPR2	2.41e-04	10	44	2	PF02815
Domain	MIR	ITPR1 ITPR2	2.41e-04	10	44	2	SM00472
Domain	MIR_motif	ITPR1 ITPR2	2.41e-04	10	44	2	IPR016093
Domain	PDEase	PDE10A PDE6B	9.04e-04	19	44	2	IPR023088
Domain	PDEase_I	PDE10A PDE6B	1.11e-03	21	44	2	PF00233
Domain	PDEASE_I	PDE10A PDE6B	1.11e-03	21	44	2	PS00126
Domain	PDEase_CS	PDE10A PDE6B	1.11e-03	21	44	2	IPR023174
Domain	-	PDE10A PDE6B	1.22e-03	22	44	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE10A PDE6B	1.33e-03	23	44	2	IPR002073
Domain	HDc	PDE10A PDE6B	1.45e-03	24	44	2	SM00471
Domain	HD/PDEase_dom	PDE10A PDE6B	1.45e-03	24	44	2	IPR003607
Domain	HormR	PTH1R PTH2R	1.57e-03	25	44	2	SM00008
Domain	Prot-tyrosine_phosphatase-like	PALD1 SBF1 TPTE2	1.63e-03	99	44	3	IPR029021
Domain	-	SEPTIN11 SEPTIN8 MTG1 ABCC12 SEPTIN10 ATAD2 SEPTIN6	1.66e-03	746	44	7	3.40.50.300
Domain	HRM	PTH1R PTH2R	1.97e-03	28	44	2	PF02793
Domain	Ion_trans_dom	TPTE2 ITPR1 ITPR2	2.44e-03	114	44	3	IPR005821
Domain	Ion_trans	TPTE2 ITPR1 ITPR2	2.44e-03	114	44	3	PF00520
Domain	GPCR_2_secretin-like_CS	PTH1R PTH2R	2.90e-03	34	44	2	IPR017983
Domain	P-loop_NTPase	SEPTIN11 SEPTIN8 MTG1 ABCC12 SEPTIN10 ATAD2 SEPTIN6	3.42e-03	848	44	7	IPR027417
Domain	G_PROTEIN_RECEP_F2_1	PTH1R PTH2R	4.00e-03	40	44	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	PTH1R PTH2R	4.00e-03	40	44	2	PS50227
Domain	GPCR_2_extracellular_dom	PTH1R PTH2R	4.00e-03	40	44	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	PTH1R PTH2R	6.18e-03	50	44	2	PS00650
Domain	7tm_2	PTH1R PTH2R	6.18e-03	50	44	2	PF00002
Domain	GPCR_2-like	PTH1R PTH2R	8.80e-03	60	44	2	IPR017981
Domain	GPCR_2_secretin-like	PTH1R PTH2R	8.80e-03	60	44	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	PTH1R PTH2R	9.09e-03	61	44	2	PS50261
Domain	ZINC_FINGER_C2H2_2	ZBTB10 ZNF765 ZNF28 TRMT1L TRPS1 ZNF445	9.21e-03	775	44	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB10 ZNF765 ZNF28 TRMT1L TRPS1 ZNF445	9.32e-03	777	44	6	PS00028
Domain	Znf_C2H2-like	ZBTB10 ZNF765 ZNF28 TRMT1L TRPS1 ZNF445	1.04e-02	796	44	6	IPR015880
Domain	Znf_C2H2	ZBTB10 ZNF765 ZNF28 TRMT1L TRPS1 ZNF445	1.10e-02	805	44	6	IPR007087
Domain	ZnF_C2H2	ZBTB10 ZNF765 ZNF28 TRMT1L TRPS1 ZNF445	1.12e-02	808	44	6	SM00355
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2	5.29e-05	5	33	2	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	7.92e-05	6	33	2	M47960
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_BIOSYNTHESIS	GYS1 GYS2	7.92e-05	6	33	2	M47620
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	1.89e-04	9	33	2	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	2.36e-04	10	33	2	M47661
Pathway	REACTOME_CGMP_EFFECTS	PDE10A ITPR1	2.36e-04	10	33	2	MM15054
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	2.88e-04	11	33	2	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2	2.88e-04	11	33	2	M27466
Pathway	REACTOME_CA2_PATHWAY	PDE6B ITPR1 ITPR2	4.02e-04	62	33	3	M27321
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	4.08e-04	13	33	2	M47751
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	4.08e-04	13	33	2	M47656
Pathway	WP_DISORDERS_OF_GALACTOSE_METABOLISM	GYS1 GYS2	4.08e-04	13	33	2	M45545
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	PDE10A ITPR1	4.08e-04	13	33	2	MM15015
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	4.08e-04	13	33	2	M47696
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	4.08e-04	13	33	2	MM14553
Pathway	REACTOME_GLYCOGEN_SYNTHESIS	GYS1 GYS2	4.75e-04	14	33	2	M27247
Pathway	REACTOME_CGMP_EFFECTS	PDE10A ITPR1	6.25e-04	16	33	2	M902
Pathway	REACTOME_GLYCOGEN_STORAGE_DISEASES	GYS1 GYS2	6.25e-04	16	33	2	M27236
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	6.25e-04	16	33	2	M26945
Pathway	REACTOME_PLATELET_HOMEOSTASIS	PDE10A ITPR1 ITPR2	7.31e-04	76	33	3	MM15051
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	8.86e-04	19	33	2	M47760
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR1 ITPR2	8.86e-04	19	33	2	M27423
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	8.86e-04	19	33	2	M47733
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	9.83e-04	20	33	2	M47688
Pathway	REACTOME_PLATELET_HOMEOSTASIS	PDE10A ITPR1 ITPR2	1.05e-03	86	33	3	M916
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.09e-03	21	33	2	M47689
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	PDE10A ITPR1	1.19e-03	22	33	2	M915
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.19e-03	22	33	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.19e-03	22	33	2	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.30e-03	23	33	2	M47676
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	PTH1R PTH2R	1.42e-03	24	33	2	MM15992
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	PTH1R PTH2R	1.42e-03	24	33	2	M39643
Pathway	REACTOME_GLYCOGEN_METABOLISM	GYS1 GYS2	1.54e-03	25	33	2	M27857
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2	1.54e-03	25	33	2	MM14511
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	KDM5B ATAD2	1.67e-03	26	33	2	MM15502
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2	1.80e-03	27	33	2	M12123
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2	1.80e-03	27	33	2	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2	1.93e-03	28	33	2	M924
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR1 ITPR2	2.52e-03	32	33	2	MM14983
Pathway	WP_GLYCOGEN_METABOLISM	GYS1 GYS2	2.84e-03	34	33	2	MM15985
Pathway	REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM	GYS1 GYS2	2.84e-03	34	33	2	M27546
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	ITPR1 ITPR2	3.19e-03	36	33	2	M1315
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	ITPR1 ITPR2	3.19e-03	36	33	2	M39831
Pathway	REACTOME_SIGNALING_BY_GPCR	CXCL16 PDE10A PTH1R PTH2R ITPR1 ITPR2	3.47e-03	646	33	6	MM14962
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	KDM5B ATAD2	3.54e-03	38	33	2	M27757
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	GYS1 GYS2	3.92e-03	40	33	2	M39595
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ITPR1 ITPR2	4.12e-03	41	33	2	M512
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR1 ITPR2	4.32e-03	42	33	2	M791
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	PDE10A PTH1R PTH2R	4.46e-03	143	33	3	MM15055
Pathway	WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME	PRL SEPTIN6 GYS1	4.64e-03	145	33	3	M45512
Pathway	WP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS	ITPR1 ITPR2	4.73e-03	44	33	2	M39845
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	PDE6B ITPR1 ITPR2	4.73e-03	146	33	3	M27288
Pathway	SIG_CHEMOTAXIS	ITPR1 ITPR2	4.94e-03	45	33	2	M5193
Pathway	SIG_BCR_SIGNALING_PATHWAY	ITPR1 ITPR2	5.16e-03	46	33	2	M8626
Pathway	REACTOME_SIGNALING_BY_GPCR	CXCL16 PDE10A PTH1R PTH2R ITPR1 ITPR2	5.22e-03	702	33	6	M746
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	PDE10A PTH1R PTH2R	5.79e-03	157	33	3	M4904
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	6.07e-03	50	33	2	M47951
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	GYS1 GYS2	6.55e-03	52	33	2	M14171
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	ITPR1 ITPR2	6.80e-03	53	33	2	MM15716
Pathway	REACTOME_ION_HOMEOSTASIS	ITPR1 ITPR2	7.05e-03	54	33	2	MM15202
Pathway	REACTOME_ION_HOMEOSTASIS	ITPR1 ITPR2	7.05e-03	54	33	2	M27460
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ITPR1 ITPR2	7.05e-03	54	33	2	M26911
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	7.30e-03	55	33	2	M47952
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE10A PDE6B	7.30e-03	55	33	2	M39763
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	PTH1R PTH2R	8.64e-03	60	33	2	MM14964
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR1 ITPR2	8.92e-03	61	33	2	MM15071
Pubmed	Localization of septin proteins in the mouse cochlea.	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	4.01e-09	16	44	4	22575789
Pubmed	Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.	SEPTIN11 SEPTIN8 SEPTIN6	1.58e-07	9	44	3	18809578
Pubmed	Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.	PTH1R PTH2R	1.56e-06	2	44	2	18539702
Pubmed	PTH-receptors regulate norepinephrine release in human heart and kidney.	PTH1R PTH2R	1.56e-06	2	44	2	21756942
Pubmed	Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release.	PTH1R PTH2R	1.56e-06	2	44	2	22896038
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	1.56e-06	2	44	2	19120126
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	1.56e-06	2	44	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	1.56e-06	2	44	2	15201137
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	1.56e-06	2	44	2	23582047
Pubmed	Androglobin, a chimeric mammalian globin, is required for male fertility.	SEPTIN11 SEPTIN8 SEPTIN10	1.80e-06	19	44	3	35700329
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	SEPTIN11 SEPTIN8 SBF1 SEPTIN6 ITPR1	1.99e-06	163	44	5	16512683
Pubmed	The imprinted Phlda2 gene regulates extraembryonic energy stores.	PRL GYS1 GYS2	2.86e-06	22	44	3	19884348
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	4.69e-06	3	44	2	31979185
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	4.69e-06	3	44	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	4.69e-06	3	44	2	9808793
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	4.69e-06	3	44	2	24904548
Pubmed	Septin expression in proliferative retinal membranes.	SEPTIN11 SEPTIN8	4.69e-06	3	44	2	17625225
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	4.69e-06	3	44	2	20395455
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	4.69e-06	3	44	2	17327232
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	4.69e-06	3	44	2	17437169
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	4.69e-06	3	44	2	23223241
Pubmed	Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.	PTH1R ITPR1	4.69e-06	3	44	2	25431134
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2	4.69e-06	3	44	2	16014380
Pubmed	Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5.	SEPTIN11 SEPTIN8	4.69e-06	3	44	2	16767699
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	4.69e-06	3	44	2	18194433
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2	4.69e-06	3	44	2	17890015
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	4.69e-06	3	44	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	4.69e-06	3	44	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	4.69e-06	3	44	2	32320395
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	4.69e-06	3	44	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	4.69e-06	3	44	2	11413485
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2	4.69e-06	3	44	2	23983250
Pubmed	Mammalian septins nomenclature.	SEPTIN8 SEPTIN10	4.69e-06	3	44	2	12475938
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	4.69e-06	3	44	2	9858485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	4.69e-06	3	44	2	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	4.69e-06	3	44	2	17581770
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2	4.69e-06	3	44	2	20427533
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	4.69e-06	3	44	2	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	4.69e-06	3	44	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	4.69e-06	3	44	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	4.69e-06	3	44	2	23955339
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	PRL GYS1 GYS2	6.75e-06	29	44	3	32798765
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2	9.37e-06	4	44	2	25215520
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2	9.37e-06	4	44	2	21424589
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2	9.37e-06	4	44	2	28419336
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	9.37e-06	4	44	2	21818117
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	9.37e-06	4	44	2	19120137
Pubmed	Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.	PTH1R PTH2R	9.37e-06	4	44	2	18280230
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	9.37e-06	4	44	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2	9.37e-06	4	44	2	35494252
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2	9.37e-06	4	44	2	28615414
Pubmed	Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight.	PRL GYS1	9.37e-06	4	44	2	36353228
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2	9.37e-06	4	44	2	10828023
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.08e-05	108	44	4	19531213
Pubmed	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	ITPR1 ITPR2	1.56e-05	5	44	2	11782428
Pubmed	Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.	SEPTIN11 SEPTIN6	1.56e-05	5	44	2	24113571
Pubmed	Septins regulate bacterial entry into host cells.	SEPTIN11 SEPTIN6	1.56e-05	5	44	2	19145258
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2	1.56e-05	5	44	2	21568942
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ZBTB10 LARP1 TRMT1L SBF1 ITPR1 ITPR2	1.86e-05	440	44	6	34244565
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	SEPTIN11 SEPTIN8 SBF1 SEPTIN6	2.06e-05	127	44	4	30442766
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	LARP1 ATAD2 SEPTIN6	2.25e-05	43	44	3	34672947
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR1 ITPR2	2.34e-05	6	44	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2	2.34e-05	6	44	2	21762810
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR1 ITPR2	2.34e-05	6	44	2	16844763
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR1 ITPR2	2.34e-05	6	44	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR1 ITPR2	2.34e-05	6	44	2	25966694
Pubmed	Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp.	PTH1R TRPS1	2.34e-05	6	44	2	18456591
Pubmed	Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.	GYS1 GYS2	2.34e-05	6	44	2	14680475
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR1 ITPR2	3.27e-05	7	44	2	11860456
Pubmed	Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.	GYS1 GYS2	3.27e-05	7	44	2	18165236
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR1 ITPR2	3.27e-05	7	44	2	22495310
Pubmed	Septin 14 is involved in cortical neuronal migration via interaction with Septin 4.	SEPTIN11 SEPTIN6	4.36e-05	8	44	2	20181826
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR1 ITPR2	5.60e-05	9	44	2	25737585
Pubmed	DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse.	SEPTIN11 SEPTIN8	6.99e-05	10	44	2	35200715
Pubmed	Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.	PTH1R PTH2R	6.99e-05	10	44	2	15670850
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	LARP1 PALD1 VPS13D C9orf72 ALG9 ITPR1	7.70e-05	568	44	6	37774976
Pubmed	Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.	ITPR1 ITPR2	8.54e-05	11	44	2	27514653
Pubmed	Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.	ITPR1 ITPR2	8.54e-05	11	44	2	20824138
Pubmed	Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange.	PRL PTH1R	1.02e-04	12	44	2	11832378
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE10A PDE6B	1.21e-04	13	44	2	8557689
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	ITPR1 ITPR2	1.41e-04	14	44	2	34630045
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	SEPTIN11 SEPTIN8 PDE10A SEPTIN6 ITPR1	1.53e-04	403	44	5	30562941
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	ITPR1 ITPR2	1.63e-04	15	44	2	28578927
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	LARP1 SEPTIN11 SEPTIN8 SBF1 ITPR2	2.06e-04	430	44	5	32581705
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	MYOM1 ITPR2	2.10e-04	17	44	2	27725084
Pubmed	Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction.	PRL GYS1	2.36e-04	18	44	2	31917811
Pubmed	Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.	PTH1R TRPS1	3.24e-04	21	44	2	29659575
Pubmed	Report of the sixth international workshop on human chromosome 3 mapping 1995.	PTH1R ITPR1	3.24e-04	21	44	2	8641130
Pubmed	Ror2 enhances polarity and directional migration of primordial germ cells.	GOLGA8B FUT4	3.24e-04	21	44	2	22216013
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE10A PDE6B	3.24e-04	21	44	2	27740716
Pubmed	The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.	ITPR1 ITPR2	3.56e-04	22	44	2	11696558
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZBTB10 SEPTIN11 SEPTIN8 PPRC1 SEPTIN6 ITPR1 ZNF445	3.92e-04	1084	44	7	11544199
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	ITPR1 ITPR2	4.24e-04	24	44	2	10843712
Pubmed	Overview of PDEs and their regulation.	PDE10A PDE6B	4.61e-04	25	44	2	17307970
Pubmed	Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta.	PRL GYS1	4.99e-04	26	44	2	27542691
Pubmed	Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.	SEPTIN8 FUT4	4.99e-04	26	44	2	15890332
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	SEPTIN11 SEPTIN8 SEPTIN10	5.39e-04	125	44	3	29467281
Pubmed	Phosphorylated tau interactome in the human Alzheimer's disease brain.	SEPTIN11 SEPTIN8 SEPTIN6	5.39e-04	125	44	3	32812023
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	ITPR1 ITPR2	6.21e-04	29	44	2	32123907
Pubmed	DNA methylation in the pathophysiology of hyperphenylalaninemia in the PAH(enu2) mouse model of phenylketonuria.	PDE10A ITPR1	6.21e-04	29	44	2	26822703
Interaction	ACAP3 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.15e-07	21	44	4	int:ACAP3
Interaction	SEPTIN12 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	2.85e-07	26	44	4	int:SEPTIN12
Interaction	SEPTIN14 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	7.72e-07	33	44	4	int:SEPTIN14
Interaction	SEPTIN4 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.38e-06	38	44	4	int:SEPTIN4
Interaction	SEPTIN1 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	3.02e-06	46	44	4	int:SEPTIN1
Interaction	SEPTIN5 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.01e-05	62	44	4	int:SEPTIN5
Interaction	SEPTIN3 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.29e-05	66	44	4	int:SEPTIN3
Interaction	CDC42EP4 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	2.51e-05	78	44	4	int:CDC42EP4
Interaction	SEPTIN8 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	3.85e-05	87	44	4	int:SEPTIN8
Interaction	SEPTIN6 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	4.03e-05	88	44	4	int:SEPTIN6
Interaction	SEPTIN11 interactions	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	1.44e-04	122	44	4	int:SEPTIN11
GeneFamily	Septins	SEPTIN11 SEPTIN8 SEPTIN10 SEPTIN6	8.31e-09	13	35	4	732
GeneFamily	Parathyroid hormone receptors	PTH1R PTH2R	3.64e-06	2	35	2	270
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	1.09e-05	3	35	2	297
GeneFamily	Glycosyl transferases group 1 domain containing	GYS1 GYS2	1.62e-04	10	35	2	427
GeneFamily	Phosphodiesterases	PDE10A PDE6B	9.78e-04	24	35	2	681
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	C9orf72 SBF1	1.06e-03	25	35	2	504
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB10 ZNF765 ZNF28 TRPS1 ZNF445	1.18e-02	718	35	5	28
Drug	thiadiazolidinone	PPRC1 GYS1 GYS2	2.41e-06	14	44	3	CID000443041
Drug	AD-5075	PPRC1 GYS1 GYS2	3.01e-06	15	44	3	CID000128440
Drug	BM 17.0744	PPRC1 GYS1 GYS2	3.71e-06	16	44	3	CID009929731
Drug	JTT-501	PPRC1 GYS1 GYS2	4.49e-06	17	44	3	CID000154000
Drug	v 405	GYS1 GYS2	1.09e-05	3	44	2	CID003057126
Drug	nicotine iminium	GYS1 GYS2	1.09e-05	3	44	2	CID000000431
Drug	AC1L9IMU	PPRC1 GYS1 GYS2	1.16e-05	23	44	3	CID000445825
Drug	MCC-555	PPRC1 GYS1 GYS2	2.91e-05	31	44	3	CID000204109
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	ZBTB10 SEPTIN11 VPS13D TRMT1L RAB3IL1	3.37e-05	192	44	5	6958_UP
Drug	m-anisidine	GYS1 GYS2	3.64e-05	5	44	2	CID000010824
Drug	bp 16	PTH1R PTH2R	3.64e-05	5	44	2	CID000127325
Drug	Tiabendazole [148-79-8]; Down 200; 19.8uM; HL60; HT_HG-U133A	VPS13D SBF1 RAB3IL1 TRPS1 ITPR2	3.81e-05	197	44	5	2479_DN
Drug	Pinacidil [85371-64-8]; Down 200; 16.4uM; PC3; HT_HG-U133A	SEPTIN11 MTG1 VPS13D RAB3IL1 ITPR1	4.09e-05	200	44	5	6356_DN
Drug	Telenzepine dihydrochloride [147416-96-4]; Up 200; 9uM; MCF7; HT_HG-U133A	SEPTIN11 VPS13D PDE6B FRMD1 SEPTIN6	4.09e-05	200	44	5	5521_UP
Drug	Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys	GYS1 GYS2	5.45e-05	6	44	2	CID003277749
Drug	phenyl glucuronide	GYS1 GYS2	5.45e-05	6	44	2	CID000087235
Drug	5-chloro-indole-2-carboxylic acid	GYS1 GYS2	5.45e-05	6	44	2	CID000082693
Drug	hexanediamine	GYS1 GYS2	5.45e-05	6	44	2	CID000134940
Drug	AC1L196J	GYS1 GYS2	5.45e-05	6	44	2	CID000000415
Drug	BAY R3401	GYS1 GYS2	5.45e-05	6	44	2	CID009842599
Drug	18-hydroxycorticosterone	PALD1 PPRC1 PRL	7.33e-05	42	44	3	CID000011222
Drug	Chloropeptide	GYS1 GYS2	7.62e-05	7	44	2	CID000025565
Drug	NSC106398	GYS1 GYS2	7.62e-05	7	44	2	CID000086763
Drug	kenpaullone	CCNB3 GYS1 GYS2	7.87e-05	43	44	3	CID000003820
Drug	gamma-glutamylhydroxamate	GYS1 GYS2	1.30e-04	9	44	2	CID000159636
Drug	alpha-chloroisocaproate	GYS1 GYS2	1.30e-04	9	44	2	CID000169071
Drug	H-47	GYS1 GYS2	1.63e-04	10	44	2	CID003083866
Drug	UDP-pyridoxal	GYS1 GYS2	1.63e-04	10	44	2	CID000126789
Drug	Hg P	SEPTIN11 GYS1 GYS2	1.65e-04	55	44	3	CID000448530
Drug	phosphonopyruvate	PALD1 PTH1R PTH2R	1.65e-04	55	44	3	CID000439811
Drug	NSC625381	MYOM1 PDE6B PPRC1 PRL	1.76e-04	145	44	4	CID000002592
Drug	orthovanadate	PDE10A SBF1 PDE6B PPRC1 GYS1 GYS2	1.79e-04	435	44	6	CID000061672
Drug	glycogen phosphorylase inhibitor	GYS1 GYS2	1.99e-04	11	44	2	CID010070301
Drug	AC1L1BIZ	GYS1 GYS2	1.99e-04	11	44	2	CID000001459
Drug	xestospongin C	ITPR1 ITPR2	2.38e-04	12	44	2	ctd:C511704
Drug	AC1LCVS1	GYS1 GYS2	2.38e-04	12	44	2	CID000656959
Drug	prostaglandin F2	PDE10A PDE6B PRL GYS1 GYS2	3.00e-04	306	44	5	CID000000160
Drug	felodipine	PDE10A PDE6B PPRC1 ITPR1	3.15e-04	169	44	4	CID000003333
Drug	p-MeC	GYS1 GYS2	3.27e-04	14	44	2	CID000451929
Drug	AC1NRAG8	GYS1 GYS2	3.27e-04	14	44	2	CID005287861
Drug	cytidine diphosphate-glucose	GYS1 GYS2	3.77e-04	15	44	2	CID000000292
Drug	M 16209	GYS1 GYS2	3.77e-04	15	44	2	CID000164260
Drug	F-6b	GYS1 GYS2	4.31e-04	16	44	2	CID000004288
Drug	Sodium thioglucse	GYS1 GYS2	4.31e-04	16	44	2	CID000151466
Drug	butylethanolamine	GYS1 GYS2	4.31e-04	16	44	2	CID000249006
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; HL60; HG-U133A	LARP1 MTG1 VPS13D RAB3IL1	4.72e-04	188	44	4	1622_DN
Drug	mannosylamine	GYS1 GYS2	4.87e-04	17	44	2	CID000192844
Drug	proglycosyn	GYS1 GYS2	4.87e-04	17	44	2	CID000147052
Drug	Nitrofural [59-87-0]; Down 200; 20.2uM; PC3; HT_HG-U133A	SEPTIN11 SBF1 GYS1 ITPR1	5.01e-04	191	44	4	6721_DN
Drug	Prednisolone [50-24-8]; Up 200; 11uM; HL60; HT_HG-U133A	SEPTIN11 ZSWIM8 SEPTIN6 TRPS1	5.01e-04	191	44	4	2393_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; HL60; HT_HG-U133A	RAB3IL1 PTH2R TRPS1 ITPR2	5.21e-04	193	44	4	1341_UP
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	PDE6B RAB3IL1 FRMD1 ITPR2	5.21e-04	193	44	4	4973_DN
Drug	Ursolic acid [77-52-1]; Up 200; 8.8uM; PC3; HT_HG-U133A	SEPTIN11 VPS13D RAB3IL1 SEPTIN6	5.21e-04	193	44	4	2067_UP
Drug	Etofylline [519-37-9]; Down 200; 17.8uM; HL60; HG-U133A	MTG1 TRMT1L ATAD2 ITPR1	5.31e-04	194	44	4	1409_DN
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A	VPS13D FUT4 PDE6B FRMD1	5.31e-04	194	44	4	5268_DN
Drug	Zalcitabine [7481-89-2]; Up 200; 19uM; MCF7; HT_HG-U133A	MTG1 VPS13D SBF1 RAB3IL1	5.31e-04	194	44	4	7352_UP
Drug	Amyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	SBF1 RAB3IL1 FRMD1 ITPR1	5.31e-04	194	44	4	4169_DN
Drug	Sulmazole [73384-60-8]; Down 200; 14uM; HL60; HT_HG-U133A	SEPTIN11 RAB3IL1 TRPS1 ITPR2	5.42e-04	195	44	4	2153_DN
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A	LARP1 FUT4 FRMD1 ITPR1	5.42e-04	195	44	4	3278_UP
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; PC3; HT_HG-U133A	VPS13D FUT4 PDE6B RAB3IL1	5.42e-04	195	44	4	6303_UP
Drug	Ioxaglic acid [59017-64-0]; Down 200; 3.2uM; HL60; HT_HG-U133A	SBF1 PTH2R TRPS1 ITPR2	5.42e-04	195	44	4	2966_DN
Drug	(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; MCF7; HT_HG-U133A	VPS13D SBF1 FRMD1 ITPR1	5.42e-04	195	44	4	4980_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	ZBTB10 SEPTIN8 ZSWIM8 TRPS1	5.42e-04	195	44	4	6926_DN
Drug	Propylthiouracil [51-52-5]; Down 200; 23.4uM; MCF7; HT_HG-U133A	RAB3IL1 FRMD1 ITPR1 ITPR2	5.42e-04	195	44	4	4157_DN
Drug	Fusaric acid [536-69-6]; Up 200; 22.4uM; MCF7; HT_HG-U133A	PTH2R SEPTIN6 ITPR1 ITPR2	5.42e-04	195	44	4	4105_UP
Drug	sucrose-6-phosphate	GYS1 GYS2	5.48e-04	18	44	2	CID000644101
Drug	1-GlcNAc	GYS1 GYS2	5.48e-04	18	44	2	CID000151446
Drug	pAPP	PDE6B PRL	5.48e-04	18	44	2	CID000121930
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	VPS13D PDE6B RAB3IL1 FRMD1	5.52e-04	196	44	4	5279_DN
Drug	Enalapril maleate [76095-16-4]; Down 200; 8.2uM; PC3; HT_HG-U133A	VPS13D FUT4 SEPTIN6 ITPR1	5.52e-04	196	44	4	7265_DN
Drug	Delcorine; Down 200; 8.4uM; MCF7; HT_HG-U133A	SEPTIN11 SBF1 RAB3IL1 ITPR2	5.52e-04	196	44	4	3613_DN
Drug	Gossypol [303-45-7]; Down 200; 7.8uM; MCF7; HT_HG-U133A	VPS13D FUT4 FRMD1 ITPR1	5.52e-04	196	44	4	3637_DN
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A	SEPTIN11 VPS13D FUT4 SEPTIN6	5.52e-04	196	44	4	2086_UP
Drug	Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; HL60; HT_HG-U133A	VPS13D SBF1 PPRC1 ITPR2	5.52e-04	196	44	4	2936_DN
Drug	Iobenguane sulfate; Down 200; 10.8uM; HL60; HG-U133A	LARP1 MTG1 VPS13D PPRC1	5.52e-04	196	44	4	1729_DN
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	VPS13D FUT4 FRMD1 SEPTIN6	5.52e-04	196	44	4	7495_DN
Drug	Isopropamide iodide [71-81-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	VPS13D PDE6B ITPR1 ITPR2	5.52e-04	196	44	4	6781_UP
Drug	Pinacidil [85371-64-8]; Down 200; 16.4uM; HL60; HT_HG-U133A	ZBTB10 SEPTIN11 ZSWIM8 VPS13D	5.52e-04	196	44	4	2406_DN
Drug	Fluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	SEPTIN11 VPS13D ITPR1 ITPR2	5.52e-04	196	44	4	6757_DN
Drug	Nefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; HL60; HT_HG-U133A	VPS13D FRMD1 PTH2R SEPTIN6	5.52e-04	196	44	4	2355_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A	FUT4 PDE6B RAB3IL1 ITPR1	5.52e-04	196	44	4	3277_UP
Drug	Thioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; PC3; HT_HG-U133A	SEPTIN11 VPS13D FUT4 RAB3IL1	5.63e-04	197	44	4	5791_DN
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; PC3; HT_HG-U133A	MTG1 VPS13D SBF1 RAB3IL1	5.63e-04	197	44	4	6611_DN
Drug	Pyrithyldione [77-04-3]; Up 200; 24uM; MCF7; HT_HG-U133A	SEPTIN11 ZSWIM8 VPS13D FRMD1	5.63e-04	197	44	4	6801_UP
Drug	Cefoxitin sodium salt [33564-30-6]; Up 200; 8.8uM; MCF7; HT_HG-U133A	ZSWIM8 VPS13D PDE10A ITPR2	5.63e-04	197	44	4	6796_UP
Drug	Esculetin [305-01-1]; Up 200; 22.4uM; MCF7; HT_HG-U133A	VPS13D FUT4 RAB3IL1 PTH1R	5.63e-04	197	44	4	7459_UP
Drug	Lincomycin hydrochloride [859-18-7]; Up 200; 9uM; MCF7; HT_HG-U133A	VPS13D FUT4 SBF1 RAB3IL1	5.63e-04	197	44	4	7411_UP
Drug	Calciferol [50-14-6]; Up 200; 10uM; MCF7; HT_HG-U133A	PDE6B RAB3IL1 ITPR1 ITPR2	5.63e-04	197	44	4	3304_UP
Drug	Hemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A	SEPTIN11 FUT4 RAB3IL1 ITPR2	5.63e-04	197	44	4	3216_DN
Drug	Gliquidone [33342-05-1]; Down 200; 7.6uM; PC3; HT_HG-U133A	SBF1 RAB3IL1 ITPR1 ITPR2	5.63e-04	197	44	4	7301_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A	SEPTIN11 SBF1 RAB3IL1 ITPR2	5.63e-04	197	44	4	4745_DN
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	SEPTIN11 VPS13D SBF1 FRMD1	5.63e-04	197	44	4	7003_UP
Drug	Dequalinium dichloride [522-51-0]; Down 200; 7.6uM; PC3; HT_HG-U133A	ZBTB10 SEPTIN8 MTG1 PPRC1	5.63e-04	197	44	4	6296_DN
Drug	Flufenamic acid [530-78-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A	PDE10A MYOM1 SEPTIN6 ITPR1	5.63e-04	197	44	4	2267_UP
Drug	Vigabatrin [60643-86-9]; Down 200; 31uM; MCF7; HT_HG-U133A	ZSWIM8 FUT4 PDE6B ITPR2	5.63e-04	197	44	4	5415_DN
Drug	Niacin [59-67-6]; Down 200; 32.4uM; HL60; HT_HG-U133A	SEPTIN11 PDE6B RAB3IL1 TRPS1	5.63e-04	197	44	4	3043_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; MCF7; HT_HG-U133A	VPS13D FUT4 SBF1 SEPTIN6	5.63e-04	197	44	4	2307_UP
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Up 200; 6uM; MCF7; HT_HG-U133A	PDE6B RAB3IL1 ITPR1 ITPR2	5.63e-04	197	44	4	2819_UP
Drug	C75; Up 200; 10uM; PC3; HT_HG-U133A	ZSWIM8 PDE6B RAB3IL1 PTH2R	5.63e-04	197	44	4	6399_UP
Drug	Pyrilamine maleate [59-33-6]; Down 200; 10uM; PC3; HT_HG-U133A	FUT4 SEPTIN6 ITPR1 ITPR2	5.74e-04	198	44	4	5869_DN
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	2.17e-06	2	44	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	2.17e-06	2	44	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	2.17e-06	2	44	2	C0995195
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	2.17e-06	2	44	2	C1140716
Disease	Lafora disease (implicated_via_orthology)	GYS1 GYS2	1.30e-05	4	44	2	DOID:3534 (implicated_via_orthology)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	1.42e-04	12	44	2	DOID:1441 (implicated_via_orthology)
Disease	behavioural inhibitory control measurement	ZBTB10 PDE10A	2.57e-04	16	44	2	EFO_0008467
Disease	osteochondrodysplasia (is_implicated_in)	PTH1R TRPS1	3.66e-04	19	44	2	DOID:2256 (is_implicated_in)
Disease	hematocrit	ZBTB10 C1orf210 PDE10A GYS2 TRPS1 ITPR1 ITPR2	6.87e-04	1011	44	7	EFO_0004348
Disease	Glycogen Storage Disease	GYS1 GYS2	7.45e-04	27	44	2	C0017919
Disease	phosphatidylcholine 38:4 measurement	RAB3IL1 ITPR2	8.01e-04	28	44	2	EFO_0010386
Disease	triacylglycerol 58:10 measurement	RAB3IL1 SEPTIN6	1.18e-03	34	44	2	EFO_0010437
Disease	sporadic amyotrophic lateral sclerosis	ABCC12 C9orf72 PTH2R	1.20e-03	140	44	3	EFO_0001357

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKCYHFVFQRYRLEH	ALG9	391	Q9H6U8
RQIYHRYCMERASVH	GYS2	236	P54840
NRLRKHLRAYHRCLY	CXCL16	56	Q9H2A7
YAVISQCIYRHRKDH	ATAD2	1356	Q6PL18
AYHFLRRYARCIHTN	CCNB3	1261	Q8WWL7
CRHRIRLGDSKSHYY	RAB3IL1	311	Q8TBN0
CYRVLRHSQQDYRKN	ITPR2	556	Q14571
HYHLREIIICTYRQA	PALD1	741	Q9ULE6
TQHVYHKYRRRCLNE	LARP1	886	Q6PKG0
CYRVLRHSQQDYRKN	ITPR1	556	Q14643
ERQARVRYYHQLSQH	FUT4	366	P22083
KDSRQHYELEYRHRA	BAIAP2L2	116	Q6UXY1
AAKCHLCRRYHASYR	C1orf210	51	Q8IVY1
GRSHRYHRKENLEYC	MTG1	131	Q9BT17
NMYHRIRHSECIYRV	PDE10A	416	Q9Y233
KIYHLSYLHNCETRR	PDE6B	221	P35913
GRQCVEHYRLLHRYC	KDM5B	611	Q9UGL1
HQLRYYDHRVDTECK	SBF1	1791	O95248
HRARHLYYCHLKERV	FRMD1	156	Q8N878
YCRKTIRHTAEYQEH	ADPRHL1	206	Q8NDY3
YYRRRHRHERTQTQK	DNAJC18	201	Q9H819
FIQYRRERCHQKVHR	GOLGA8B	441	A8MQT2
RQIYHRYCMERAAAH	GYS1	236	P13807
YRSHDHYQRQRVLQK	PPRC1	1521	Q5VV67
CHEHIYNQRRYMRSE	C9orf72	321	Q96LT7
YYNLLHCLRRDSHKI	PRL	196	P01236
YAKAQHVARRHYGCN	TRMT1L	406	Q7Z2T5
REQTHTRHYELYRRC	SEPTIN11	286	Q9NVA2
KYDHQRYQHTVRVCG	ABCC12	566	Q96J65
HTRHYELYRRCKLEE	SEPTIN6	291	Q14141
ISRHYRRAHSCYKCR	TRPS1	681	Q9UHF7
ECYIQYHHSKIRNRG	TMEM192	111	Q8IY95
YDFNHKGHAYRRCDR	PTH1R	136	Q03431
QTHSRHYELYRRCKL	SEPTIN8	291	Q92599
REQTHTRHYELYRRC	SEPTIN10	311	Q9P0V9
IGYFRRLHCTRNYIH	PTH2R	166	P49190
VQRCQQAYMQYIHHR	ZSWIM8	1761	A7E2V4
YRHQRIHSLQKQYDC	ZNF445	806	P59923
SYDRNYRLVNHQRIH	ZNF445	876	P59923
VFNQKRYLACHRRSH	ZNF28	251	P17035
VFNSKRYVARHRRCH	ZNF765	251	Q7L2R6
RFLDKKHRNHYRVYN	TPTE2	251	Q6XPS3
KHRNHYRVYNLCSER	TPTE2	256	Q6XPS3
HCSYVAKYRRTLKRH	ZBTB10	726	Q96DT7
NRHQSEREYIRYHAA	VPS13D	4126	Q5THJ4
YQRCHQHYDLSYRNK	MYOM1	6	P52179