Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1C PIP5K1A PIPSL	1.26e-05	9	108	3	GO:0016308
GeneOntologyMolecularFunction	structural constituent of postsynaptic density	DLGAP1 SHANK3 SHANK2	2.46e-05	11	108	3	GO:0098919
GeneOntologyMolecularFunction	structural constituent of postsynaptic specialization	DLGAP1 SHANK3 SHANK2	4.23e-05	13	108	3	GO:0098879
GeneOntologyMolecularFunction	lipid kinase activity	PIP5K1C DGKK PIP5K1A PIPSL	7.02e-05	41	108	4	GO:0001727
GeneOntologyMolecularFunction	structural constituent of synapse	DLGAP1 PCLO SHANK3 SHANK2	7.73e-05	42	108	4	GO:0098918
GeneOntologyMolecularFunction	SH3 domain binding	SHANK3 PTPN12 SHANK2 WASF2 NCF1C NCF1B	1.28e-04	143	108	6	GO:0017124
GeneOntologyMolecularFunction	synaptic receptor adaptor activity	SHANK3 SHANK2	1.73e-04	4	108	2	GO:0030160
GeneOntologyMolecularFunction	clathrin adaptor activity	AP2A1 SNAP91 EPN1	2.20e-04	22	108	3	GO:0035615
GeneOntologyMolecularFunction	cargo adaptor activity	AP2A1 SNAP91 EPN1	3.25e-04	25	108	3	GO:0140312
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIP5K1C PIP5K1A PIPSL	3.65e-04	26	108	3	GO:0052742
GeneOntologyMolecularFunction	structural constituent of postsynapse	DLGAP1 SHANK3 SHANK2	6.81e-04	32	108	3	GO:0099186
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1C NCF1B	1.27e-03	10	108	2	GO:0016176
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	ELOB ZSWIM8 ANK3 GON4L SHANK3 RETREG3 KMT2D SHANK2 AP2A1 SNAP91 MDC1 SYNE2 ARID5B EPN1 MAPK8IP2	1.44e-03	1160	108	15	GO:0030674
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1C NCF1B	1.85e-03	12	108	2	GO:0016175
GeneOntologyCellularComponent	MLL3/4 complex	PAGR1 KDM6B KMT2D	2.77e-05	12	107	3	GO:0044666
GeneOntologyCellularComponent	postsynaptic density	DLGAP1 ANK3 PCLO CRTC1 PIP5K1C SHANK3 SHANK2 SNAP91 MACF1 MAPK8IP2	1.08e-04	451	107	10	GO:0014069
GeneOntologyCellularComponent	clathrin coat of coated pit	EPS15L1 AP2A1 SNAP91	1.62e-04	21	107	3	GO:0030132
GeneOntologyCellularComponent	asymmetric synapse	DLGAP1 ANK3 PCLO CRTC1 PIP5K1C SHANK3 SHANK2 SNAP91 MACF1 MAPK8IP2	1.70e-04	477	107	10	GO:0032279
GeneOntologyCellularComponent	clathrin coat	EPS15L1 AP2A1 SNAP91 EPN1	1.94e-04	56	107	4	GO:0030118
GeneOntologyCellularComponent	postsynaptic specialization	DLGAP1 ANK3 PCLO CRTC1 PIP5K1C SHANK3 SHANK2 SNAP91 MACF1 MAPK8IP2	2.60e-04	503	107	10	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	DLGAP1 ANK3 PCLO CRTC1 PIP5K1C SHANK3 SHANK2 SNAP91 MACF1 MAPK8IP2	3.54e-04	523	107	10	GO:0098984
GeneOntologyCellularComponent	clathrin-coated pit	EPS15L1 AP2A1 SNAP91 EPN1	7.61e-04	80	107	4	GO:0005905
GeneOntologyCellularComponent	clathrin vesicle coat	AP2A1 SNAP91 EPN1	9.66e-04	38	107	3	GO:0030125
Domain	PDZ	ARHGAP23 PCLO SHANK3 GORASP2 SHANK2 AHNAK2	1.70e-04	151	101	6	PS50106
Domain	PDZ	ARHGAP23 PCLO SHANK3 GORASP2 SHANK2 AHNAK2	1.77e-04	152	101	6	IPR001478
Domain	HECT	TRIP12 HERC1 HERC6	4.09e-04	27	101	3	PF00632
Domain	HECTc	TRIP12 HERC1 HERC6	4.09e-04	27	101	3	SM00119
Domain	HECT_dom	TRIP12 HERC1 HERC6	4.09e-04	27	101	3	IPR000569
Domain	HECT	TRIP12 HERC1 HERC6	4.09e-04	27	101	3	PS50237
Domain	PInositol-4-P-5-kinase	PIP5K1C PIP5K1A	5.97e-04	7	101	2	IPR023610
Domain	PIPKc	PIP5K1C PIP5K1A	7.94e-04	8	101	2	SM00330
Domain	-	PIP5K1C PIP5K1A	7.94e-04	8	101	2	3.30.800.10
Domain	PIP5K	PIP5K1C PIP5K1A	7.94e-04	8	101	2	PF01504
Domain	PIPK	PIP5K1C PIP5K1A	7.94e-04	8	101	2	PS51455
Domain	PInositol-4-P-5-kinase_N	PIP5K1C PIP5K1A	7.94e-04	8	101	2	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP5K1C PIP5K1A	7.94e-04	8	101	2	IPR027483
Domain	-	PIP5K1C PIP5K1A	7.94e-04	8	101	2	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP5K1C PIP5K1A	7.94e-04	8	101	2	IPR002498
Domain	ENTH	SNAP91 EPN1	1.02e-03	9	101	2	PS50942
Domain	zf-C2H2_11	ZKSCAN1 ZNF592	1.02e-03	9	101	2	PF16622
Domain	ENTH	SNAP91 EPN1	1.02e-03	9	101	2	SM00273
Domain	PDZ	ARHGAP23 SHANK3 GORASP2 SHANK2 AHNAK2	1.26e-03	148	101	5	SM00228
Domain	ENTH	SNAP91 EPN1	1.27e-03	10	101	2	IPR013809
Domain	-	ARHGAP23 SHANK3 GORASP2 SHANK2 AHNAK2	1.33e-03	150	101	5	2.30.42.10
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX3 LMTK2 LAMC3 MLXIP KDM6B PIP5K1C MAP3K5 HIVEP3 EPS15L1 KMT2D SHANK2 AP2A1 ZFP36L2 ZNF592 NBEAL2 NAV1 HERC1 PRRC2B AHNAK2	1.59e-09	1105	109	19	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RAPH1 WEE1 RBBP6 FNBP4 PAGR1 TRIP12 ZNF768 EPS15L1 KMT2D PTPRC ZNF592 MDC1 PKN2 ZMYM3 TOP2B CDC23	2.71e-09	774	109	16	15302935
Pubmed	Functional proteomics mapping of a human signaling pathway.	ANK3 RBBP6 FNBP4 TRIP12 VSIR CUEDC1 KMT2D PTPN12 PTPRC AP2A1 ZNF592 MACF1 HERC1 EPN1	5.25e-09	591	109	14	15231748
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ANK3 RAPH1 FXR2 RBBP6 CRTC1 TRIP12 ZNF592 MDC1 MACF1 PRRC2B CPSF7	2.01e-08	361	109	11	26167880
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP1 ANK3 PCLO KCNB2 SHANK3 SHANK2 AP2A1 MACF1 PKN2 GNAS	2.13e-08	281	109	10	28706196
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DLGAP1 ANK3 FXR2 SHANK3 MAP3K5 EPS15L1 SHANK2 AP2A1 ZKSCAN1 SNAP91 WASF2 SYNE2 NAV1 MACF1 MAPK8IP2 PRRC2B	5.68e-08	963	109	16	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAPH1 WEE1 LMTK2 CRTC1 MLXIP DPP8 TRIP12 ZFP36L2 STARD9 SYNE2 NAV1 MACF1 GNAS AHNAK2 DOP1B	8.34e-08	861	109	15	36931259
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	EPS15L1 AP2A1 EPN1	2.98e-07	5	109	3	9723620
Pubmed	Functional assay of effectors of ADP ribosylation factor 6 during clathrin/AP-2 coat recruitment to membranes.	PIP5K1C AP2A1 SNAP91	5.95e-07	6	109	3	16413285
Pubmed	Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling.	PIP5K1C AP2A1 PIP5K1A	5.95e-07	6	109	3	15123724
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GON4L MLXIP PIP5K1C STARD9 NAV1 MACF1 TET3 ZMYM3 PRRC2B DOP1B	6.57e-07	407	109	10	12693553
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	SALL3 RBBP6 TRIP12 ZNF592 ZMYM3 TOP2B	9.21e-07	103	109	6	32744500
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ELOB PCNX3 RBBP6 ARHGAP10 GON4L CRTC1 ZNF768 CUEDC1 GORASP2 SHANK2 ZKSCAN1 ZFP36L2 ZNF592 WASF2 MDC1 MACF1 EPN1 ZMYM3	9.37e-07	1497	109	18	31527615
Pubmed	Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.	DLGAP1 SHANK3 SHANK2	1.04e-06	7	109	3	10527873
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	FXR2 WEE1 FNBP4 LMTK2 TRIP12 SMG8 ZNF592 MDC1 TOP2B CDC23	1.33e-06	440	109	10	34244565
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	DLGAP1 SHANK3 SHANK2 WASF2	2.04e-06	29	109	4	19208628
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZSWIM8 WEE1 RBBP6 ARID5B NAV1 MACF1 GNAS ZMYM3 PRRC2B CDC23 CPSF7	2.53e-06	588	109	11	38580884
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ELOB RBBP6 FNBP4 PAGR1 MLXIP TRIP12 ZNF768 KMT2D AP2A1 MDC1 ARID5B TET3 ZMYM3 TOP2B CDC23 CPSF7	2.83e-06	1294	109	16	30804502
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	ANK3 RAPH1 PCNX3 PIP5K1C GORASP2 WASF2 PIP5K1A PKN2 GNAS	3.09e-06	377	109	9	38117590
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ZSWIM8 RAPH1 WEE1 CRTC1 PAGR1 MLXIP EPS15L1 GORASP2 SHANK2 AP2A1 ZFP36L2 GNAS EPN1 CDC23	4.70e-06	1038	109	14	26673895
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DLGAP1 ARHGAP23 FXR2 SHANK3 SNAP91 STARD9 ACAN MACF1 MAPK8IP2	8.90e-06	430	109	9	32581705
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ANK3 RAPH1 RBBP6 FNBP4 EPS15L1 KMT2D MDC1 PKN2 PRRC2B CDC23	9.33e-06	549	109	10	38280479
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GON4L TRIP12 KMT2D MDC1 MACF1 HERC1 TOP2B	9.50e-06	234	109	7	36243803
Pubmed	Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development.	SHANK3 SHANK2	9.73e-06	2	109	2	10506216
Pubmed	Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.	GP6 PTPRC	9.73e-06	2	109	2	31226719
Pubmed	PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.	PIP5K1C PIP5K1A	9.73e-06	2	109	2	18073347
Pubmed	Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.	PIP5K1C PIP5K1A	9.73e-06	2	109	2	12682053
Pubmed	Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.	SHANK3 SHANK2	9.73e-06	2	109	2	33126897
Pubmed	Intrinsically disordered proteins drive membrane curvature.	SNAP91 EPN1	9.73e-06	2	109	2	26204806
Pubmed	Synapse structure: glutamate receptors connected by the shanks.	DLGAP1 SHANK3	9.73e-06	2	109	2	10574750
Pubmed	Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane.	PIP5K1C PIP5K1A	9.73e-06	2	109	2	32376619
Pubmed	Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion.	SHANK3 MAPK8IP2	9.73e-06	2	109	2	23225497
Pubmed	TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.	KDM6B TET3	9.73e-06	2	109	2	32405722
Pubmed	Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.	PIP5K1C PIP5K1A	9.73e-06	2	109	2	19153220
Pubmed	Functional pseudogenes inhibit the superoxide production.	NCF1C NCF1B	9.73e-06	2	109	2	26086043
Pubmed	Expression profiles of the autism-related SHANK proteins in the human brain.	SHANK3 SHANK2	9.73e-06	2	109	2	37953224
Pubmed	Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.	SHANK3 SHANK2	9.73e-06	2	109	2	36100669
Pubmed	Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.	PIP5K1C PIP5K1A	9.73e-06	2	109	2	23300084
Pubmed	Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.	SHANK3 SHANK2	9.73e-06	2	109	2	22699619
Pubmed	Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system.	SHANK3 SHANK2	9.73e-06	2	109	2	20800661
Pubmed	Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.	SHANK3 SHANK2	9.73e-06	2	109	2	31052177
Pubmed	PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.	PIP5K1C PIP5K1A	9.73e-06	2	109	2	19889969
Pubmed	Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.	SHANK3 SHANK2	9.73e-06	2	109	2	27199660
Pubmed	SHANK3 in vagal sensory neurons regulates body temperature, systemic inflammation, and sepsis.	SHANK3 SHANK2	9.73e-06	2	109	2	36845137
Pubmed	Human transcription factor protein interaction networks.	RBBP6 BCL7B GON4L PAGR1 ZNF768 KMT2D ZKSCAN1 ZNF592 DGKK MDC1 SYNE2 ARID5B HERC1 ZMYM3 PRRC2B CPSF7	9.87e-06	1429	109	16	35140242
Pubmed	Redundant and nonredundant organismal functions of EPS15 and EPS15L1.	EPS15L1 AP2A1 EPN1	1.06e-05	14	109	3	30692166
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	DLGAP1 SHANK3 SHANK2	1.06e-05	14	109	3	21795692
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZSWIM8 ARHGAP23 FXR2 WEE1 RBBP6 ARHGAP10 BCL7B ZNF768 ZNF592 MACF1 VPS53 ZMYM3 PRRC2B CDC23	1.07e-05	1116	109	14	31753913
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZSWIM8 DLGAP1 ANK3 MAGEH1 KDM6B TRIP12 CUEDC1 EPS15L1 GORASP2 AP2A1 ZNF592 ARID5B MACF1 MAPK8IP2 DOP1B	1.18e-05	1285	109	15	35914814
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DLGAP1 PCLO EPS15L1 AMER2 SHANK2 AP2A1 SNAP91 MACF1	1.43e-05	347	109	8	17114649
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	ELOB ANK3 WEE1 ARHGAP10 CRTC1 DPP8 EPS15L1 GORASP2 AP2A1 ZFP36L2 PTPRQ NAV1 VPS53 PRRC2B CDC23	1.63e-05	1321	109	15	27173435
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	BCL7B PAGR1 KMT2D MDC1 ARID5B PRRC2B CPSF7	2.28e-05	268	109	7	33640491
Pubmed	The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.	EPS15L1 AP2A1 EPN1	2.36e-05	18	109	3	10567358
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	FXR2 RBBP6 ARHGAP10 PCLO ARID5B MACF1 PIPSL NCF1C DEUP1	2.74e-05	496	109	9	31343991
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1C NCF1B	2.91e-05	3	109	2	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1C NCF1B	2.91e-05	3	109	2	10678931
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1C NCF1B	2.91e-05	3	109	2	27044504
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1C NCF1B	2.91e-05	3	109	2	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1C NCF1B	2.91e-05	3	109	2	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1C NCF1B	2.91e-05	3	109	2	10891396
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1C NCF1B	2.91e-05	3	109	2	25474113
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1C NCF1B	2.91e-05	3	109	2	18787174
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1C NCF1B	2.91e-05	3	109	2	26209274
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1C NCF1B	2.91e-05	3	109	2	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1C NCF1B	2.91e-05	3	109	2	22184329
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1C NCF1B	2.91e-05	3	109	2	11018074
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1C NCF1B	2.91e-05	3	109	2	33545139
Pubmed	The Shank family of scaffold proteins.	SHANK3 SHANK2	2.91e-05	3	109	2	10806096
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1C NCF1B	2.91e-05	3	109	2	20142487
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1C NCF1B	2.91e-05	3	109	2	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1C NCF1B	2.91e-05	3	109	2	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1C NCF1B	2.91e-05	3	109	2	21570954
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1C NCF1B	2.91e-05	3	109	2	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1C NCF1B	2.91e-05	3	109	2	39357591
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1C NCF1B	2.91e-05	3	109	2	12958309
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1C NCF1B	2.91e-05	3	109	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1C NCF1B	2.91e-05	3	109	2	31118934
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1C NCF1B	2.91e-05	3	109	2	23482812
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1C NCF1B	2.91e-05	3	109	2	16041040
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1C NCF1B	2.91e-05	3	109	2	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1C NCF1B	2.91e-05	3	109	2	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1C NCF1B	2.91e-05	3	109	2	21435178
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1C NCF1B	2.91e-05	3	109	2	18703411
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1C NCF1B	2.91e-05	3	109	2	29228045
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1C NCF1B	2.91e-05	3	109	2	17307863
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1C NCF1B	2.91e-05	3	109	2	22155727
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1C NCF1B	2.91e-05	3	109	2	27829407
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1C NCF1B	2.91e-05	3	109	2	24576409
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1C NCF1B	2.91e-05	3	109	2	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1C NCF1B	2.91e-05	3	109	2	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1C NCF1B	2.91e-05	3	109	2	28274989
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1C NCF1B	2.91e-05	3	109	2	26645958
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1C NCF1B	2.91e-05	3	109	2	12364355
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1C NCF1B	2.91e-05	3	109	2	24549323
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1C NCF1B	2.91e-05	3	109	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1C NCF1B	2.91e-05	3	109	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1C NCF1B	2.91e-05	3	109	2	10670582
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1C NCF1B	2.91e-05	3	109	2	20881184
Pubmed	Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.	PIP5K1C PIP5K1A	2.91e-05	3	109	2	14681219
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1C NCF1B	2.91e-05	3	109	2	26528554
Interaction	TOP3B interactions	PCNX3 FXR2 LMTK2 LAMC3 MLXIP KDM6B PIP5K1C MAP3K5 HIVEP3 EPS15L1 GORASP2 KMT2D SHANK2 AP2A1 ZFP36L2 ZNF592 NBEAL2 MDC1 NAV1 GNAS HERC1 ADAMTSL4 PRRC2B AHNAK2	4.90e-07	1470	106	24	int:TOP3B
Interaction	AGAP2 interactions	DLGAP1 ANK3 PCLO SHANK3 SHANK2 AP2A1 MACF1 PKN2 GNAS	1.67e-06	210	106	9	int:AGAP2
Interaction	YWHAG interactions	DLGAP1 RAPH1 ARHGAP23 WEE1 SH2D3A LMTK2 CRTC1 MLXIP TRIP12 SHANK3 MAP3K5 ZFP36L2 STARD9 WASF2 SYNE2 NAV1 MACF1 PKN2 GNAS ZMYM3 AHNAK2	1.81e-06	1248	106	21	int:YWHAG
Interaction	RAPGEF5 interactions	ANK3 ARHGAP23 ARHGAP10 HERC1 MAPK8IP2	1.59e-05	60	106	5	int:RAPGEF5
Interaction	YWHAH interactions	DLGAP1 FXR2 WEE1 LMTK2 CRTC1 MLXIP DPP8 TRIP12 MAP3K5 ZFP36L2 STARD9 WASF2 SYNE2 NAV1 MACF1 HERC1 AHNAK2 DOP1B	1.66e-05	1102	106	18	int:YWHAH
Interaction	ARHGAP12 interactions	RAPH1 FNBP4 SHANK3 SHANK2 WASF2	2.93e-05	68	106	5	int:ARHGAP12
Interaction	TNIK interactions	DLGAP1 ANK3 FXR2 SHANK3 SHANK2 AP2A1 SNAP91 SYNE2 MACF1 PRRC2B	3.30e-05	381	106	10	int:TNIK
Interaction	AMPH interactions	SHANK3 AP2A1 SNAP91 EPN1 DEUP1	3.87e-05	72	106	5	int:AMPH
Interaction	UBXN6 interactions	ZSWIM8 TRIP12 MAP3K5 YOD1 SMG8 NAV1 PKN2 HERC1 CDC23	5.50e-05	325	106	9	int:UBXN6
Interaction	NRXN1 interactions	DLGAP1 ARHGAP10 KCNB2 AMER2 MACF1 SYTL1	5.67e-05	127	106	6	int:NRXN1
Interaction	NECAP1 interactions	AP2A1 SNAP91 MDC1 EPN1 TOP2B	5.70e-05	78	106	5	int:NECAP1
Interaction	NCK2 interactions	RAPH1 FXR2 CUEDC1 PTPN12 WASF2 SYNE2 PKN2 CPSF7	7.37e-05	262	106	8	int:NCK2
Interaction	YWHAB interactions	DLGAP1 ARHGAP23 WEE1 SH2D3A CRTC1 MLXIP DPP8 TRIP12 SHANK3 MAP3K5 ZFP36L2 STARD9 WASF2 NAV1 MACF1 AHNAK2	7.78e-05	1014	106	16	int:YWHAB
Interaction	CECR2 interactions	FXR2 WEE1 ZNF768 PRRC2B	9.95e-05	46	106	4	int:CECR2
Interaction	NEDD4 interactions	ANK3 WEE1 KDM6B PIP5K1C SHANK3 MAP3K5 CUEDC1 YOD1 ZFP36L2 PIP5K1A PKN2	1.38e-04	544	106	11	int:NEDD4
Interaction	RAPGEF4 interactions	DLGAP1 PCLO SHANK3 GNAS	1.38e-04	50	106	4	int:RAPGEF4
Cytoband	7q11.23	BCL7B PTPN12 NCF1C NCF1B	8.79e-05	97	109	4	7q11.23
GeneFamily	PDZ domain containing	ARHGAP23 PCLO SHANK3 GORASP2 SHANK2 AHNAK2	2.69e-05	152	70	6	1220
Coexpression	GSE37416_CTRL_VS_12H_F_TULARENSIS_LVS_NEUTROPHIL_UP	GALNT10 MLXIP RETREG3 MAP3K5 ZFP36L2 WASF2 PKN2 HERC1	1.52e-06	195	108	8	M5334
Coexpression	GSE25088_ROSIGLITAZONE_VS_IL4_AND_ROSIGLITAZONE_STIM_STAT6_KO_MACROPHAGE_DAY10_UP	VSIR MAP3K5 KMT2D PTPRC ZFP36L2 SYNE2 GNAS NCF1C	1.70e-06	198	108	8	M7948
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	ANK3 RAPH1 ARHGAP23 PCLO SHANK3 HIVEP3 AMER2 SHANK2 SNAP91 ANKIB1 NAV1 HERC1 VPS53 MAPK8IP2 PRRC2B AHNAK2 DOP1B	2.77e-06	1106	108	17	M39071
Coexpression	GSE3982_MEMORY_CD4_TCELL_VS_TH2_UP	RETREG3 MAP3K5 KMT2D ZFP36L2 SYNE2 MACF1 HERC1	1.73e-05	196	108	7	M5381
Coexpression	GSE9988_LPS_VS_CTRL_TREATED_MONOCYTE_DN	PAGR1 MLXIP DPP8 PIP5K1C RETREG3 SMG8 WASF2	1.97e-05	200	108	7	M5859
Coexpression	AIZARANI_LIVER_C20_LSECS_3	STAB2 ARHGAP23 RBBP6 KDM6B SHANK3 NAV1 MACF1 HERC1	3.11e-05	295	108	8	M39121
Coexpression	ZHENG_BOUND_BY_FOXP3	RBBP6 MAP3K5 EPS15L1 PTPRC ZFP36L2 SYNE2 ARID5B MACF1 TET3 TOP2B	4.11e-05	498	108	10	M1741
Coexpression	ZHENG_BOUND_BY_FOXP3	RBBP6 MAP3K5 EPS15L1 PTPRC ZFP36L2 SYNE2 ARID5B MACF1 TET3 TOP2B	4.78e-05	507	108	10	MM1030
Coexpression	RODRIGUES_NTN1_TARGETS_DN	RAPH1 MLXIP VSIR IER3 ARID5B PIP5K1A	5.58e-05	161	108	6	M11857
Coexpression	GSE27241_CTRL_VS_DIGOXIN_TREATED_CD4_TCELL_IN_TH17_POLARIZING_CONDITIONS_UP	RAPH1 MLXIP IER3 ARID5B ADAMTSL4 DOP1B	5.78e-05	162	108	6	M8243
Coexpression	SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP	RBBP6 FNBP4 ZKSCAN1 ZFP36L2 PIP5K1A HERC1	7.31e-05	169	108	6	M40877
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	FXR2 RBBP6 FNBP4 KMT2D SLC12A9 PIP5K1A EPN1 CPSF7	8.09e-05	338	108	8	M17094
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	GALNT10 MXRA5 GON4L PAGR1 MLXIP RETREG3 MAP3K5 SHANK2 ZFP36L2 SYNE2 GNAS HERC1	1.25e-04	807	108	12	M16651
Coexpression	GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_UP	AMH RBBP6 SH2D3A CUEDC1 PIGA HERC1	1.35e-04	189	108	6	M9978
Coexpression	GAVIN_PDE3B_TARGETS	SYTL1 NCF1C NCF1B	1.46e-04	25	108	3	MM726
Coexpression	GSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN	TRABD2B PCNX3 KMT2D ARID5B EPN1 PRRC2B	1.79e-04	199	108	6	M9443
Coexpression	GSE13484_UNSTIM_VS_3H_YF17D_VACCINE_STIM_PBMC_UP	DPP8 KMT2D NBEAL2 WASF2 ZMYM3 DOP1B	1.79e-04	199	108	6	M3257
Coexpression	GSE22886_DAY0_VS_DAY7_MONOCYTE_IN_CULTURE_UP	FNBP4 PTPRC NBEAL2 PKN2 NCF1C TET3	1.79e-04	199	108	6	M4460
Coexpression	GSE31082_DN_VS_CD8_SP_THYMOCYTE_DN	GALNT10 KMT2D PTPRC ZNF592 HERC6 DOP1B	1.84e-04	200	108	6	M5063
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	PCNX3 KMT2D ZKSCAN1 ZFP36L2 TOP2B PRRC2B	1.84e-04	200	108	6	M9439
Coexpression	GSE28737_FOLLICULAR_VS_MARGINAL_ZONE_BCELL_BCL6_HET_UP	RAPH1 KMT2D PTPRC ZFP36L2 STARD9 NAV1	1.84e-04	200	108	6	M9354
Coexpression	GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN	PAGR1 MLXIP DPP8 PIP5K1C RETREG3 ZFP36L2	1.84e-04	200	108	6	M5851
Coexpression	GSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_DN	PAGR1 DPP8 PIP5K1C RETREG3 ZFP36L2 WASF2	1.84e-04	200	108	6	M5870
Coexpression	GSE360_HIGH_VS_LOW_DOSE_B_MALAYI_MAC_UP	ANK3 FXR2 FNBP4 KCNB2 KMT2D PRRC2B	1.84e-04	200	108	6	M5261
Coexpression	GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_6H_DN	MAGEH1 FNBP4 SHANK3 YOD1 ZFP36L2 HERC1	1.84e-04	200	108	6	M9923
Coexpression	GSE10094_LCMV_VS_LISTERIA_IND_EFF_CD4_TCELL_DN	AMH ARHGAP23 FXR2 SLC12A9 ALOXE3 DEUP1	1.84e-04	200	108	6	M3047
ToppCell	B_cells-Activate_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ANK3 WEE1 ZC3H6 PTPN12 PTPRC ZFP36L2 ARID5B	5.86e-07	198	109	7	a663082d7fbd6db11d3d3024bbb8ba00183e19f8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP1 ANK3 PCLO KCNB2 SHANK2 SNAP91 HERC1	5.86e-07	198	109	7	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	DLGAP1 ANK3 PCLO KCNB2 SHANK2 SNAP91 HERC1	6.27e-07	200	109	7	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	normal-na-Lymphocytic_T-T4_em-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ANK3 PTPRC ZFP36L2 SYNE2 ARID5B MACF1	4.04e-06	171	109	6	61318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell	normal_Lymph_Node-Myeloid_cells-Activated_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	RAPH1 ARHGAP10 CCDC81 IER3 NAV1 FOXD4	7.40e-06	190	109	6	15978ddd37b521343f88b62dad1643077fc22b2b
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZKSCAN1 WASF2 SYNE2 ANKIB1 PKN2 TOP2B	7.62e-06	191	109	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	(1)_T_CD4_fh\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	ANK3 VSIR PTPRC ZFP36L2 SYNE2 ARID5B	7.62e-06	191	109	6	66ddff9a99092cb384b9fb2a3ba95ddbebed67cc
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZKSCAN1 WASF2 SYNE2 ANKIB1 PKN2 TOP2B	7.62e-06	191	109	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZKSCAN1 WASF2 SYNE2 ANKIB1 PKN2 TOP2B	7.62e-06	191	109	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A1BG GP6 PTPRC SYNE2 SYTL1 NCF1B	8.09e-06	193	109	6	7deb439943d35a4e825674b2b7dcddb45d366ad1
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WEE1 WASF2 ARID5B MACF1 PKN2 TET3	8.33e-06	194	109	6	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ANK3 PTPRC ZFP36L2 SYNE2 ARID5B HERC6	8.33e-06	194	109	6	0b0042b6a356a49a059fb64a1e1abb25c82d48cf
ToppCell	droplet-Limb_Muscle-MUSCLE-1m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WEE1 RBBP6 TP53INP2 GORASP2 ACAN ARID5B	8.58e-06	195	109	6	fee9d13f48149cd5f921cfe4b8b3053cf6a6dbd2
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SH2D3A SHANK2 SLC12A9 SYNE2 PTPRQ ALOXE3	9.09e-06	197	109	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANK3 PTPRC SYNE2 ARID5B MACF1 HERC1	9.09e-06	197	109	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mLN-(5)_Dendritic_cell-(53)_Lymphoid_DC\|mLN / shred on region, Cell_type, and subtype	RAPH1 ARHGAP10 IER3 NAV1 ADAMTSL4 FOXD4	9.36e-06	198	109	6	da84c76afe835aeee39da04b63c03549218b5d91
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|mLN / Region, Cell class and subclass	RAPH1 ARHGAP10 IER3 NAV1 ADAMTSL4 FOXD4	9.36e-06	198	109	6	3965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SH2D3A SHANK2 SLC12A9 NBEAL2 SYNE2 PTPRQ	9.63e-06	199	109	6	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	mild-CD4+_Tcm\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANK3 ZFP36L2 SYNE2 ARID5B MACF1 HERC6	9.63e-06	199	109	6	06c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	ANK3 KDM6B SHANK2 NAV1 MAPK8IP2 PRRC2B	9.91e-06	200	109	6	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	PTPN12 PTPRC DGKK SYNE2 MACF1 HERC6	9.91e-06	200	109	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	FNBP4 KDM6B PTPRC ZFP36L2 PKN2 GNAS	9.91e-06	200	109	6	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	RBBP6 TRIP12 IER3 SYNE2 GNAS	2.28e-05	138	109	5	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	A1BG CRTC1 MAP3K5 KMT2D PRRC2B	3.63e-05	152	109	5	aa88084ba1851d879ece82baa516f6b46cbd2eb8
ToppCell	PBMC-Control-cDC_8\|Control / Compartment, Disease Groups and Clusters	GP6 AMH ARHGAP23 CCDC81 TP53INP2	3.74e-05	153	109	5	db1a6914f2033fb0748e0523cffe5d6dc4e901be
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	ANK3 PTPRC SYNE2 MACF1 HERC1	4.11e-05	156	109	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	ANK3 FNBP4 PTPRC SYNE2 MACF1	4.91e-05	162	109	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Pro-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A1BG GP6 CCDC81 MLXIP TOP2B	6.35e-05	171	109	5	58bdcbc65062ac09f1c014e08302f938a3e6b252
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KDM6B PTPRC SYNE2 MACF1 HERC1	6.35e-05	171	109	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK3 ACKR4 ABCA9 AP2A1 ADAMTSL4	7.47e-05	177	109	5	7af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCell	facs-Brain_Myeloid-Striatum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ABCA9 WASF2 MACF1 GNAS	7.47e-05	177	109	5	efb1990fd1d216f64261e81017299783afb24a1e
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 MAP3K5 SHANK2 NBEAL2 PTPRQ	7.47e-05	177	109	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK3 WEE1 LMTK2 YOD1 MACF1	7.88e-05	179	109	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLGAP1 TRABD2B PCLO SHANK2 SYNE2	8.09e-05	180	109	5	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	facs-Spleen-nan-3m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLXIP PTPRC ZFP36L2 MACF1 TOP2B	8.09e-05	180	109	5	87fb1fdbc49c808bb5f6fe9fb747057b45fa78d0
ToppCell	facs-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLXIP PTPRC ZFP36L2 MACF1 TOP2B	8.09e-05	180	109	5	c0c3144011856d005aebd5cdc79f89fee32083a8
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ANK3 PTPRC SYNE2 MACF1 HERC1	8.30e-05	181	109	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	COVID-19_Severe-PLT_1\|COVID-19_Severe / Disease Group and Platelet Clusters	RBBP6 MAP3K7CL VSIR EPS15L1 IER3	8.30e-05	181	109	5	20f7603ceb89b965570e39ae3e88a6d26ebf5b67
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 PTPRC WASF2 MACF1 TOP2B	8.52e-05	182	109	5	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	RBBP6 TRIP12 IER3 SYNE2 PKN2	8.75e-05	183	109	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 STAB2 PCLO DGKK PTPRQ	8.97e-05	184	109	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRC ZFP36L2 WASF2 MACF1 TOP2B	8.97e-05	184	109	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 STAB2 PCLO DGKK PTPRQ	8.97e-05	184	109	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 STAB2 PCLO DGKK PTPRQ	8.97e-05	184	109	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP23 CUEDC1 PTPN12 IER3 ADAMTSL4	9.20e-05	185	109	5	7bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 WEE1 IER3 ARID5B GNAS	9.20e-05	185	109	5	74b787e225d83efcb84e79c23499febe1a106622
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA9 PTPRC WASF2 MACF1 TOP2B	9.20e-05	185	109	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	LPS_only\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MLXIP KDM6B HIVEP3 PTPRC IER3	9.20e-05	185	109	5	a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP10 CCDC81 IER3 NAV1 FOXD4	9.20e-05	185	109	5	48de4d9fad55077732bf64eca4919103ecbc1512
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GALNT10 CRTC1 RETREG3 SYTL1 HERC6	9.20e-05	185	109	5	7925519b855f76444a0b57382ce35d89457b0b14
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARHGAP23 MAGEH1 ACKR4 SHANK3	9.44e-05	186	109	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARHGAP23 MAGEH1 ACKR4 SHANK3	9.44e-05	186	109	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 TRABD2B ANK3 KCNB2 SYNE2	9.44e-05	186	109	5	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GALNT10 PTPRC ZKSCAN1 GNAS ZMYM3	9.68e-05	187	109	5	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LMTK2 PIGA SHANK2 NBEAL2 PTPRQ	9.68e-05	187	109	5	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRABD2B ANK3 PCLO SHANK2 SYNE2	9.68e-05	187	109	5	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARHGAP23 ACKR4 SHANK3 DEUP1	9.93e-05	188	109	5	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM6B WASF2 SYNE2 ARID5B PKN2	9.93e-05	188	109	5	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	15-Distal-Mesenchymal-Pericyte\|Distal / Age, Tissue, Lineage and Cell class	LAMC3 MAP3K7CL AMER2 STARD9 ACAN	9.93e-05	188	109	5	4963382e54aac06bf5047c7d725393db70667ee7
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDM6B VSIR PTPRC ZFP36L2 IER3	9.93e-05	188	109	5	53213d0c907ce4522fc00699cb38fa78ed0bef7e
ToppCell	ASK452-Immune-T_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SHANK3 PTPRC SYNE2 ARID5B HERC1	1.02e-04	189	109	5	f5dc500f77f04a110dd4a65cf4c03068a495dbdb
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARHGAP23 ACKR4 SHANK3 DEUP1	1.04e-04	190	109	5	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANK3 MAP3K5 SYNE2 MACF1 SYTL1	1.04e-04	190	109	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ARHGAP23 ACKR4 SHANK3 DEUP1	1.04e-04	190	109	5	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	(1)_T_cells-(1)_T_CD4_fh\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CRTC1 VSIR PTPRC ZFP36L2 ARID5B	1.04e-04	190	109	5	120ca702600373c208a3d032fede0a040736e5cf
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ANK3 PTPRC SYNE2 ARID5B HERC6	1.04e-04	190	109	5	f6616b3fe7f4962249503c96c06926240066d861
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CCDC81 MLXIP WASF2 PKN2 TOP2B	1.07e-04	191	109	5	40813c397f533c2f4a6359a77757f736b6d9e07d
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ANK3 PTPRC SYNE2 MACF1 HERC1	1.10e-04	192	109	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCLO KCNB2 AMER2 SNAP91 MAPK8IP2	1.10e-04	192	109	5	fe9297cb65234d9f511bab1a5dbf2679d5a4cd15
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ANK3 PTPRC SYNE2 ARID5B HERC6	1.10e-04	192	109	5	e07b6892276c81c1227e94ca942f6820d89a7ca3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RAPH1 SH2D3A ZFP36L2 IER3 ARID5B	1.10e-04	192	109	5	2510f22197502f60fd266b7f42eff040f25b8ae7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RAPH1 SH2D3A ZFP36L2 IER3 ARID5B	1.10e-04	192	109	5	e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	TRABD2B ANK3 SHANK2 SYNE2 MACF1	1.10e-04	192	109	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ARHGAP23 ACKR4 SHANK3 NAV1	1.12e-04	193	109	5	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ARHGAP23 ACKR4 SHANK3 NAV1	1.12e-04	193	109	5	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCLO KCNB2 AMER2 SNAP91 MAPK8IP2	1.12e-04	193	109	5	a189d46c39067b717509cd144e0225cc93d7731d
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	ANK3 SH2D3A ZFP36L2 SYNE2 ARID5B	1.12e-04	193	109	5	498d3a83bce6deff69aea71b18a43688e0a8ed7d
ToppCell	10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CCDC81 MLXIP WASF2 ARID5B TOP2B	1.15e-04	194	109	5	f64da5f62e29253d60b9546edf734ba5c17daae1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 TRABD2B ANK3 SHANK2 SYNE2	1.15e-04	194	109	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	myeloid-CD16+_Monocyte\|myeloid / Lineage and Cell class	VSIR PTPRC AP2A1 WASF2 SYTL1	1.15e-04	194	109	5	aeeadfeb01827dbc7de6576c76fb2e41a3c59247
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	ANK3 SH2D3A ZFP36L2 SYNE2 ARID5B	1.18e-04	195	109	5	a72bb5b1b15dd1ab70ced5622d94499caff8bb6b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 ARHGAP10 LAMC3 ABCA9 MAP3K5	1.18e-04	195	109	5	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	COPD-Lymphoid-T\|COPD / Disease state, Lineage and Cell class	ANK3 PTPRC ZFP36L2 SYNE2 ARID5B	1.21e-04	196	109	5	30e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANK3 PTPRC ZFP36L2 SYNE2 MACF1	1.21e-04	196	109	5	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP1 PCLO KCNB2 SHANK2 SNAP91	1.21e-04	196	109	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	tumor_Lung-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	KDM6B VSIR ZFP36L2 IER3 SYNE2	1.21e-04	196	109	5	7aa6778b78a8549dd4d0a5278ef8017334b00c38
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ANK3 PTPRC ZFP36L2 SYNE2 ARID5B	1.21e-04	196	109	5	4a880a5d2c7047c050c7d6dd62186f35dc5c01f7
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPRC ZFP36L2 SYNE2 ARID5B SYTL1	1.24e-04	197	109	5	ef2d1f56acd0be43e69bba7f73f6909ba87f1cb3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 TRABD2B ANK3 SHANK2 SYNE2	1.24e-04	197	109	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	ELOB VSIR PTPRC ZFP36L2 GNAS	1.24e-04	197	109	5	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	normal_Lung-T/NK_cells-CD8_low_T\|normal_Lung / Location, Cell class and cell subclass	PTPRC ZFP36L2 SYNE2 ARID5B SYTL1	1.24e-04	197	109	5	559b22ff973a1551e614a972085343e7d8e8a668
ToppCell	T_cells-Treg_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DLGAP1 LAMC3 PTPRC SYNE2 ARID5B	1.24e-04	197	109	5	de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCell	Severe_COVID-19-T/NK-CD4+_T_1\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ANK3 PTPRC ZFP36L2 SYNE2 SYTL1	1.27e-04	198	109	5	bc6b983fdb9547ef8a9e693bc15fced1b73e101f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANK3 ZFP36L2 SYNE2 ARID5B SYTL1	1.27e-04	198	109	5	8a7897d98f5296745d9005a7cd777f0a2f78000d
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANK3 PTPRC ZFP36L2 SYNE2 SYTL1	1.27e-04	198	109	5	fc8099bce80d84b29bdcc87064d4d8375dddfa0f
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive_helper_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ANK3 VSIR PTPRC ZFP36L2 SYNE2	1.27e-04	198	109	5	c4d8d133e571ad3a7c5de93aa7befb67cb7a003d
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	SH2D3A SHANK2 NBEAL2 SYNE2 PTPRQ	1.27e-04	198	109	5	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ANK3 PTPRC ZFP36L2 SYNE2 SYTL1	1.27e-04	198	109	5	32ec322ed144c545014b191da5274d12feeaf96b
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ANK3 PTPRC ZFP36L2 SYNE2 SYTL1	1.27e-04	198	109	5	1e281d8f0291e8cf814e9e5abd7f5860402a7c77
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDM6B VSIR PTPRC SLC24A4 IER3	1.27e-04	198	109	5	72c7474e084d1334a09c0a3b0f3c3137038794c8
Drug	benz(a)anthracene	ANK3 RAPH1 ARHGAP23 WEE1 RBBP6 PCLO MAGEH1 BCL7B FNBP4 GON4L CCDC81 ZC3H6 VSIR IER3 SYNE2 HERC1 ZMYM3 AHNAK2	2.03e-05	1251	107	18	ctd:C030935
Drug	Furosemide [54-31-9]; Up 200; 12uM; PC3; HT_HG-U133A	ZSWIM8 STAB2 CRTC1 LAMC3 SHANK2 ACAN EPN1	3.60e-05	193	107	7	4503_UP
Drug	Cotinine (-) [486-56-6]; Up 200; 22.6uM; PC3; HG-U133A	GALNT10 FXR2 SH2D3A CRTC1 CUEDC1 SHANK2 ALOXE3	3.97e-05	196	107	7	1929_UP
Drug	Homosalate [118-56-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A	AMH CRTC1 ZKSCAN1 ZFP36L2 GNAS VPS53 CPSF7	4.10e-05	197	107	7	4355_DN
Drug	tamoxifen citrate; Down 200; 1uM; ssMCF7; HG-U133A	DLGAP1 GALNT10 MXRA5 STAB2 FXR2 ACAN DOP1B	4.10e-05	197	107	7	375_DN
Drug	U-62066 [87151-85-7]; Down 200; 1uM; PC3; HT_HG-U133A	GON4L ZNF768 MAP3K5 HIVEP3 PTPN12 SHANK2 SLC12A9	4.10e-05	197	107	7	4553_DN
Drug	Cephapirin sodium salt [24356-60-3]; Down 200; 9uM; HL60; HT_HG-U133A	KDM6B EPS15L1 NBEAL2 HERC6 VPS53 ZMYM3 CPSF7	4.23e-05	198	107	7	2730_DN
Drug	Tolazoline hydrochloride [59-97-2]; Up 200; 20.4uM; PC3; HG-U133A	ELOB ZSWIM8 BCL7B SH2D3A HIVEP3 ACAN PRRC2B	4.23e-05	198	107	7	1918_UP
Drug	FK-506; Down 200; 1uM; MCF7; HG-U133A	WEE1 KDM6B HIVEP3 ACAN MACF1 ALOXE3 EPN1	4.23e-05	198	107	7	169_DN
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ZSWIM8 FXR2 MAP3K5 CUEDC1 ZKSCAN1 ZFP36L2 PRRC2B	4.23e-05	198	107	7	7174_DN
Drug	Ioversol [87771-40-2]; Up 200; 5uM; MCF7; HT_HG-U133A	GP6 STAB2 ARHGAP10 PIP5K1C HIVEP3 SHANK2 VPS53	4.23e-05	198	107	7	5326_UP
Drug	Ungerine nitrate; Up 200; 10.2uM; HL60; HT_HG-U133A	ANK3 PCLO SH2D3A LAMC3 KMT2D GNAS MAPK8IP2	4.37e-05	199	107	7	2514_UP
Drug	Perphenazine [58-39-9]; Down 200; 10uM; PC3; HT_HG-U133A	AMH CRTC1 LAMC3 MAP3K7CL SLC12A9 GNAS MAPK8IP2	4.37e-05	199	107	7	4637_DN
Disease	Manic	ANK3 SHANK3 SHANK2 ZNF592 STARD9	1.07e-05	78	109	5	C0338831
Disease	estradiol measurement	ARHGAP10 BCL7B SHANK2 WASF2 NAV1	5.64e-05	110	109	5	EFO_0004697
Disease	cancer (implicated_via_orthology)	RBBP6 PIP5K1C TRIP12 PIP5K1A MACF1 PIPSL TOP2B	6.38e-05	268	109	7	DOID:162 (implicated_via_orthology)
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1C NCF1B	1.34e-04	5	109	2	DOID:3265 (implicated_via_orthology)
Disease	Manic Disorder	ANK3 SHANK2 ZNF592 STARD9	1.41e-04	71	109	4	C0024713
Disease	language measurement	DLGAP1 ANK3 GON4L EPS15L1 PKN2	1.43e-04	134	109	5	EFO_0007797
Disease	Mental Retardation, Psychosocial	GON4L KDM6B SHANK3 SHANK2 GNAS	1.70e-04	139	109	5	C0025363
Disease	Profound Mental Retardation	GON4L KDM6B SHANK3 SHANK2 GNAS	1.70e-04	139	109	5	C0020796
Disease	Mental deficiency	GON4L KDM6B SHANK3 SHANK2 GNAS	1.70e-04	139	109	5	C0917816
Disease	bipolar I disorder	ANK3 CDAN1 SHANK2 ZNF592 STARD9	1.82e-04	141	109	5	EFO_0009963
Disease	glucagon measurement, glucose tolerance test	MACF1 HERC1	2.01e-04	6	109	2	EFO_0004307, EFO_0008463
Disease	Depression, Bipolar	ANK3 SHANK2 ZNF592 STARD9	2.14e-04	79	109	4	C0005587
Disease	Intellectual Disability	GON4L KDM6B SHANK3 SHANK2 MACF1 GNAS TET3 VPS53	2.61e-04	447	109	8	C3714756
Disease	Autism Spectrum Disorders	LAMC3 TRIP12 SHANK3 TET3	2.83e-04	85	109	4	C1510586
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	DLGAP1 HIVEP3 PTPRC ARID5B TET3	4.31e-04	170	109	5	EFO_0000685, EFO_0007791, EFO_0007837
Disease	urate measurement	PCNX3 LMTK2 GON4L CCDC81 MLXIP TP53INP2 SHANK2 NAV1 GNAS HERC6 PRRC2B	4.84e-04	895	109	11	EFO_0004531
Disease	serum gamma-glutamyl transferase measurement	AMH PCNX3 ARHGAP10 BCL7B LMTK2 GON4L MAP3K7CL ZNF768 SLC24A4 NBEAL2 PKN2	5.76e-04	914	109	11	EFO_0004532
Disease	Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement	CRTC1 KCNB2	7.28e-04	11	109	2	EFO_0009923
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1C NCF1B	8.71e-04	12	109	2	DOID:7148 (implicated_via_orthology)
Disease	bipolar disorder	ANK3 PCLO CDAN1 KMT2D SHANK2 SNAP91 SLC12A9 STARD9	1.38e-03	577	109	8	MONDO_0004985
Disease	total blood protein measurement	ZSWIM8 CRTC1 MAP3K5 EPS15L1 KMT2D ARID5B MACF1	1.42e-03	449	109	7	EFO_0004536
Disease	Schizoaffective disorder-bipolar type	STAB2 PCLO	1.57e-03	16	109	2	EFO_0009965
Disease	Pontoneocerebellar hypoplasia	PCLO VPS53	1.57e-03	16	109	2	cv:C1261175
Disease	cutaneous melanoma, hair color	TP53INP2 SLC24A4 SYNE2	1.58e-03	62	109	3	EFO_0000389, EFO_0003924
Disease	breast carcinoma (is_marker_for)	KDM6B KMT2D MDC1	1.89e-03	66	109	3	DOID:3459 (is_marker_for)
Disease	uric acid measurement	PCNX3 LMTK2 MLXIP GORASP2 NAV1 GNAS ZMYM3 PRRC2B	1.95e-03	610	109	8	EFO_0004761
Disease	basophil count, eosinophil count	ELOB KDM6B HIVEP3 PTPRC PKN2	2.04e-03	241	109	5	EFO_0004842, EFO_0005090
Disease	body fat percentage	CRTC1 KCNB2 TRIP12 HIVEP3 ACAN MACF1 PRRC2B	2.27e-03	488	109	7	EFO_0007800
Disease	body weight	GALNTL6 GON4L CRTC1 OTOL1 MAP3K7CL KCNB2 TRIP12 TP53INP2 SLC24A4 ACAN DGKK GNAS	2.43e-03	1261	109	12	EFO_0004338
Disease	autism spectrum disorder (implicated_via_orthology)	FXR2 LAMC3 SHANK3 SHANK2	2.48e-03	152	109	4	DOID:0060041 (implicated_via_orthology)
Disease	esophagus squamous cell carcinoma (is_marker_for)	PAGR1 KMT2D TET3	2.63e-03	74	109	3	DOID:3748 (is_marker_for)
Disease	unipolar depression, bipolar disorder	ANK3 PCLO STARD9 SYNE2	2.72e-03	156	109	4	EFO_0003761, MONDO_0004985
Disease	eosinophilic esophagitis	GALNTL6 CCDC81 OTOL1 SHANK2	3.18e-03	163	109	4	EFO_0004232

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPDPFQTEDPFKSDP	EPS15L1	616	Q9UBC2
PDPASVDPPSDPSAD	AMER2	346	Q8N7J2
EIPPAPEESFTTIPD	CABS1	216	Q96KC9
ETPTTEVPAPFFLPA	CDC23	561	Q9UJX2
EEAIPSPTPRAEPFS	ADAMTSL4	191	Q6UY14
DPTPNDCFEPVSPEF	ABCA9	461	Q8IUA7
EAFLSELEPPAPESP	AP2A1	701	O95782
NPPDPDEPSESTLDI	ANKIB1	786	Q9P2G1
DFDTDFDPSILPPPD	DLGAP1	756	O14490
SEAQISDPFAPEPTP	SNAP91	396	O60641
PLVSDDDVFPLSPPD	DEUP1	536	Q05D60
DDVFPLSPPDMSFPA	DEUP1	541	Q05D60
EPSLPSSEVADEPPT	BCL7B	146	Q9BQE9
PTVPEDLFFLEEGPS	CDAN1	756	Q8IWY9
PVEADFLSPFSVPEA	SLC24A4	406	Q8NFF2
VVEFPSPPSDSDFPP	RAPH1	1061	Q70E73
FSLDSEDPSPASPPL	PAGR1	226	Q9BTK6
GPPPSTVSEAEFEDI	CPSF7	326	Q8N684
DPFPQESPLDTFPEP	NOBOX	401	O60393
PDPDTPPLTIFSSND	YOD1	276	Q5VVQ6
LSDETLPAPEFSPEP	A1BG	301	P04217
VEEFPFDSEGPTEPT	ACKR4	331	Q9NPB9
EKIFRTPPDTTFPEP	ARHGAP10	571	A1A4S6
ATEPASEPAPEPATE	DGKK	86	Q5KSL6
SGPEIFTFDPLPEPA	IER3	31	P46695
KPVEPAASDLEPFTP	MDC1	1651	Q14676
PEEDPSTPEEASTTP	MAGEH1	51	Q9H213
PSEFLPSFPLVPESS	GORASP2	361	Q9H8Y8
LLDTSEPEPPVDSEP	FXR2	521	P51116
PELQKADPSDPFESP	GALNT10	301	Q86SR1
TPGPDSPIFLPTDSE	ALOXE3	371	Q9BYJ1
PADSPGTPFLDFPVT	DOP1B	2261	Q9Y3R5
FPESFTVPDLEPVPE	HERC1	3946	Q15751
FDFPPTPLEDQFEEP	KDM6B	671	O15054
SIEEASSPASEPEPP	MAPK8IP2	296	Q13387
RLPTEPPSPVAEFSE	GP6	211	Q9HCN6
PSIESDPEGFEISPE	PCLO	1861	Q9Y6V0
DTDPPSEAELPASPD	PCNX3	336	Q9H6A9
PFLPSDPEPPETSEE	PERCC1	21	A0A1W2PR82
RTLEPDSSDEEPPPV	CUEDC1	116	Q9NWM3
PAETPSPVIFSDFPF	HERC6	611	Q8IVU3
EEPTSPAAAVPTPEE	MACF1	1011	O94854
EEPTSPAAAVPTPEE	MACF1	1076	O94854
ASPAAAVPTPEEPAF	MACF1	1131	O94854
PFPASEPSLETPDSL	LMTK2	986	Q8IWU2
PSAELEESPPSADPF	AMH	276	P03971
PSDPSEFGTEFRAPP	FOXD4	76	Q12950
EISEGSPIPDPSFSP	PIP5K1A	521	Q99755
IPASFLEPLDSPDET	NCF1B	206	A6NI72
IPASFLEPLDSPDET	NCF1C	181	A8MVU1
EVSPSPLEPEEPFTF	ACAN	406	P16112
EPSPSEVPFPSEEPS	ACAN	786	P16112
EVPFPSEEPSPSEEP	ACAN	791	P16112
SEEPSPSEEPFPSVR	ACAN	796	P16112
ELFPSEEPFPSKEPS	ACAN	816	P16112
EEPFPSKEPSPSEEP	ACAN	821	P16112
PSEEPSASEEPYTPS	ACAN	831	P16112
PPFLPEEPSSSSEED	RBBP6	236	Q7Z6E9
EGSPTPDPSFSPLVE	PIPSL	471	A2A3N6
PISILTEEDAPDSPP	PTPRQ	886	Q9UMZ3
EDPFIQPTDFGPSEP	MLXIP	406	Q9HAP2
TDFTETERSPLPPPS	KCNB2	611	Q92953
EALCIEPFSSPPELP	ELOB	86	Q15370
SRLPPFEPDSSEPIF	CCDC81	496	Q6ZN84
PLDPEEPTFPALSSS	CRTC1	261	Q6UUV9
PLPDYTPPEIFSFES	DPP8	626	Q6V1X1
PPTFASPETAPEVET	GON4L	1556	Q3T8J9
ESTPTSEPNPFPFHE	ANK3	3591	Q12955
DFSPPEVPEPTFLEN	MANBAL	6	Q9NQG1
ADVFTAPAPAPTTDP	EPN1	261	Q9Y6I3
PEDFPEPSPASSPSE	SALL3	91	Q9BXA9
PSSGPPPEEEETLFT	OTOL1	46	A6NHN0
PDENFEDHSAPPSPE	MAP3K5	1021	Q99683
TPPEDSIPLVFPELD	MAP3K7CL	26	P57077
PESDDQSELPSPPAL	NAV1	971	Q8NEY1
DHINFPVFEPSTPDP	SMG8	646	Q8ND04
PELQRADPSDPFESP	GALNTL6	296	Q49A17
DFPSPSVPLKASDPE	SYTL1	156	Q8IYJ3
SDVDIFPSDFPTEPP	TOP2B	1581	Q02880
PLPSFDEVDSGDQPP	SYNE2	6776	Q8WXH0
PEPEPDTEPDSTAAV	FNBP4	31	Q8N3X1
PDLLPCTPPSFEEAT	PIP5K1C	506	O60331
YTTPEDATPEPGEDP	GNAS	961	Q5JWF2
PTESPAEPSDVFLPS	NBEAL2	1321	Q6ZNJ1
AEPSDVFLPSEAPCP	NBEAL2	1326	Q6ZNJ1
EDSPPPLPERTPESF	PTPN12	671	Q05209
EPFPGSADEIPTETF	STARD9	1221	Q9P2P6
FDDEFTSEAPILTPP	PKN2	946	Q16513
ADTPIEEFTPTPAFP	SHANK2	646	Q9UPX8
FPAPSSEDDVFIPTV	AHNAK2	5396	Q8IVF2
PESEPQEASFPSFPT	ARID5B	586	Q14865
IPNAVDPTDFTPDPF	PIGA	206	P37287
DPEESFARDLPDFPS	RETREG3	321	Q86VR2
EDSAFQEPDSPLPPA	WEE1	51	P30291
TPPEHFPFSDPEDDF	ZC3H6	401	P61129
SSLFFSTPSPPEDPD	TP53INP2	6	Q8IXH6
AETPIEEFTPTPAFP	SHANK3	591	Q9BYB0
SVTPTAPPEDEDPAL	TRABD2B	391	A6NFA1
TPSFELPDASERPPT	SH2D3A	216	Q9BRG2
LAQSPASFPPEASEP	ARHGAP23	451	Q9P227
PGDVFFPSLDPVPDS	VSIR	291	Q9H7M9
FPSLDPVPDSPNFEV	VSIR	296	Q9H7M9
FSPISSPEPEDPIKD	ZNF592	141	Q92610
PPQDHFLTDPAFSEP	SLC12A9	636	Q9BXP2
EFEPQSPRFEPESPG	ZNF768	71	Q9H5H4
PSPEFAPRSPESDSQ	ZNF768	96	Q9H5H4
TAQSLEDPPPFVEPS	HIVEP3	331	Q5T1R4
PEFPAQETPTTFPEE	PRRC2B	576	Q5JSZ5
PPEPSYDPFTDSEER	STAB2	2526	Q8WWQ8
SSAFPPATPRTEFPE	TET3	421	O43151
ESPPPSTNPFLEDEP	VPS53	376	Q5VIR6
SFSEDNLPPPPAEFS	WASF2	261	Q9Y6W5
PSTFLPEPPDTYEED	ZSWIM8	656	A7E2V4
DSTLQDTPPPDPEIF	ZKSCAN1	41	P17029
PTPPENITFEDPSLD	TRIP12	1456	Q14669
PVFDAPPSPPDSLSD	ZFP36L2	441	P47974
DPPSEPSPLEAEFQR	PTPRC	936	P08575
MDPSDFPSPFDPLTL	ZMYM3	1	Q14202
EASPLSPPFEESPLS	KMT2D	541	O14686
ETSEDVAPPLPPFHF	LAMC3	611	Q9Y6N6
SSPEPTSSEYEPPLD	MXRA5	951	Q9NR99