Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	6.80e-13	37	72	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	8.58e-13	38	72	8	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	5.03e-08	11	72	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.51e-07	14	72	4	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10	8.88e-07	21	72	4	GO:0035613
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 OMA1 TMPRSS6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.15e-06	430	72	10	GO:0004175
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10	9.38e-06	37	72	4	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.05e-05	38	72	4	GO:0034061
GeneOntologyMolecularFunction	structural molecule activity	ROCK2 ERVK-6 FN1 MRPL51 ERVK-8 ERVK-5 PAPLN ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.57e-05	891	72	13	GO:0005198
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.26e-05	46	72	4	GO:0016893
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	3.84e-05	3	72	2	GO:0018858
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	7.66e-05	4	72	2	GO:0102391
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 OMA1 TMPRSS6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.14e-04	654	72	10	GO:0008233
GeneOntologyMolecularFunction	protein-arginine deiminase activity	PADI3 PADI1	1.27e-04	5	72	2	GO:0004668
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.90e-04	79	72	4	GO:0004521
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	3.54e-04	8	72	2	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	6.91e-04	11	72	2	GO:0031956
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	PADI3 PADI1	6.91e-04	11	72	2	GO:0016813
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 MIB1 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.30e-03	891	72	10	GO:0008270
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.48e-03	136	72	4	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.48e-03	136	72	4	GO:0004519
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.22e-03	152	72	4	GO:0016779
GeneOntologyMolecularFunction	translation elongation factor activity	EFL1 GFM1	2.34e-03	20	72	2	GO:0003746
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERVK-8 ERVK-7 ERVK-10 HELB	2.56e-03	262	72	5	GO:0140097
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	2.58e-03	21	72	2	GO:0016408
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 FN1 MIB1 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.39e-03	1189	72	11	GO:0046914
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	3.94e-03	26	72	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	4.25e-03	27	72	2	GO:0016405
GeneOntologyMolecularFunction	calcium ion binding	CELSR3 BCL2L10 OTOF CLEC4A SLIT1 PLCD1 PADI3 PADI1	5.44e-03	749	72	8	GO:0005509
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A ACSM2B	5.57e-03	31	72	2	GO:0016878
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10	7.11e-08	13	67	4	GO:0015074
GeneOntologyBiologicalProcess	viral process	ERVK-6 AVPR1B ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	2.37e-06	464	67	10	GO:0016032
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	8.34e-06	85	67	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	8.34e-06	85	67	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.04e-05	89	67	5	GO:0006949
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.78e-05	48	67	4	GO:0000731
GeneOntologyBiologicalProcess	triglyceride homeostasis	DGAT2 FUNDC2 ACSM2A MED13	2.09e-05	50	67	4	GO:0070328
GeneOntologyBiologicalProcess	acylglycerol homeostasis	DGAT2 FUNDC2 ACSM2A MED13	2.27e-05	51	67	4	GO:0055090
GeneOntologyBiologicalProcess	regulation of anatomical structure size	ROCK2 DIP2B AKT3 FN1 AVPR1B SLIT1 VAV1 EDNRB SLC12A5 ARF6	2.89e-05	618	67	10	GO:0090066
GeneOntologyBiologicalProcess	regulation of cell size	DIP2B AKT3 FN1 SLIT1 VAV1 SLC12A5	9.03e-05	225	67	6	GO:0008361
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.54e-04	83	67	4	GO:0006278
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 ERVK-8 ERVK-7 ERVK-10 HELB	2.83e-04	178	67	5	GO:0006261
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	ROCK2 ARL3 CYTH1 ARHGAP9 EPS8L1 ARHGAP39 VAV1 ARF6	3.43e-04	538	67	8	GO:0007264
Domain	FerI	OTOF FER1L6	1.11e-04	5	63	2	SM01202
Domain	FerB	OTOF FER1L6	1.11e-04	5	63	2	SM01201
Domain	PAD_C	PADI3 PADI1	1.11e-04	5	63	2	IPR013530
Domain	Ferlin_B-domain	OTOF FER1L6	1.11e-04	5	63	2	IPR012561
Domain	Prot_Arg_deaminase_cen_dom	PADI3 PADI1	1.11e-04	5	63	2	IPR013733
Domain	PAD_N	PADI3 PADI1	1.11e-04	5	63	2	IPR013732
Domain	Ferlin_C	OTOF FER1L6	1.11e-04	5	63	2	PF16165
Domain	Ferlin_C	OTOF FER1L6	1.11e-04	5	63	2	IPR032362
Domain	FerIin_dom	OTOF FER1L6	1.11e-04	5	63	2	IPR012968
Domain	FerI	OTOF FER1L6	1.11e-04	5	63	2	PF08151
Domain	FerB	OTOF FER1L6	1.11e-04	5	63	2	PF08150
Domain	PAD	PADI3 PADI1	1.11e-04	5	63	2	PF03068
Domain	PAD_N	PADI3 PADI1	1.11e-04	5	63	2	PF08526
Domain	PAD_M	PADI3 PADI1	1.11e-04	5	63	2	PF08527
Domain	PAD	PADI3 PADI1	1.11e-04	5	63	2	IPR004303
Domain	EFG_II	EFL1 GFM1	1.11e-04	5	63	2	PF14492
Domain	PH	ROCK2 AKT3 CYTH1 ARHGAP9 PLCD1 VAV1	1.21e-04	229	63	6	PF00169
Domain	AMP-binding	DIP2B ACSM2A ACSM2B	1.39e-04	30	63	3	PF00501
Domain	AMP-dep_Synth/Lig	DIP2B ACSM2A ACSM2B	1.39e-04	30	63	3	IPR000873
Domain	EFG_III-V	EFL1 GFM1	1.67e-04	6	63	2	IPR009022
Domain	EFG_C	EFL1 GFM1	1.67e-04	6	63	2	SM00838
Domain	EFG_C	EFL1 GFM1	1.67e-04	6	63	2	PF00679
Domain	-	EFL1 GFM1	2.33e-04	7	63	2	3.30.70.240
Domain	EFG_V	EFL1 GFM1	2.33e-04	7	63	2	IPR000640
Domain	PH	ROCK2 AKT3 CYTH1 ARHGAP9 PLCD1 VAV1	3.44e-04	278	63	6	SM00233
Domain	PH_DOMAIN	ROCK2 AKT3 CYTH1 ARHGAP9 PLCD1 VAV1	3.50e-04	279	63	6	PS50003
Domain	PH_domain	ROCK2 AKT3 CYTH1 ARHGAP9 PLCD1 VAV1	3.57e-04	280	63	6	IPR001849
Domain	PH_dom-like	ROCK2 AKT3 CYTH1 ARHGAP9 PLCD1 EPS8L1 VAV1	5.63e-04	426	63	7	IPR011993
Domain	BAH	TNRC18 BAHCC1	6.04e-04	11	63	2	SM00439
Domain	BAH	TNRC18 BAHCC1	6.04e-04	11	63	2	PF01426
Domain	BAH	TNRC18 BAHCC1	6.04e-04	11	63	2	PS51038
Domain	BAH_dom	TNRC18 BAHCC1	6.04e-04	11	63	2	IPR001025
Domain	G_TR_1	EFL1 GFM1	8.53e-04	13	63	2	PS00301
Domain	AMP-bd_C	ACSM2A ACSM2B	1.47e-03	17	63	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	1.47e-03	17	63	2	PF13193
Domain	EFTu-like_2	EFL1 GFM1	1.65e-03	18	63	2	IPR004161
Domain	GTP_EFTU_D2	EFL1 GFM1	1.65e-03	18	63	2	PF03144
Domain	G_TR_2	EFL1 GFM1	1.65e-03	18	63	2	PS51722
Domain	TF_GTP-bd_dom	EFL1 GFM1	1.85e-03	19	63	2	IPR000795
Domain	-	ROCK2 AKT3 CYTH1 ARHGAP9 PLCD1 VAV1	2.01e-03	391	63	6	2.30.29.30
Domain	-	EFL1 GFM1	2.26e-03	21	63	2	3.30.230.10
Domain	Small_GTP-bd_dom	EFL1 ARL3 GFM1 ARF6	2.44e-03	167	63	4	IPR005225
Domain	Ribosomal_S5_D2-typ_fold_subgr	EFL1 GFM1	2.48e-03	22	63	2	IPR014721
Domain	Cupredoxin	PADI3 PADI1	2.48e-03	22	63	2	IPR008972
Domain	zf-CCHC	ERVK-6 ERVK-5	2.71e-03	23	63	2	PF00098
Domain	AMP-binding_CS	ACSM2A ACSM2B	3.45e-03	26	63	2	IPR020845
Domain	Transl_B-barrel	EFL1 GFM1	3.72e-03	27	63	2	IPR009000
Domain	AMP_BINDING	ACSM2A ACSM2B	4.00e-03	28	63	2	PS00455
Domain	HRM	CELSR3 ADGRF3	4.00e-03	28	63	2	PF02793
Domain	ARF	ARL3 ARF6	4.29e-03	29	63	2	PS51417
Domain	Small_GTPase_ARF	ARL3 ARF6	4.29e-03	29	63	2	IPR024156
Domain	-	DGCR2 CLEC4A HAPLN3	4.30e-03	97	63	3	3.10.100.10
Domain	C-type_lectin-like/link	DGCR2 CLEC4A HAPLN3	4.56e-03	99	63	3	IPR016186
Domain	Arf	ARL3 ARF6	4.89e-03	31	63	2	PF00025
Domain	Small_GTPase_ARF/SAR	ARL3 ARF6	5.53e-03	33	63	2	IPR006689
Domain	CTDL_fold	DGCR2 CLEC4A HAPLN3	5.66e-03	107	63	3	IPR016187
Domain	GPS	CELSR3 ADGRF3	5.86e-03	34	63	2	SM00303
Domain	Ribosomal_S5_D2-typ_fold	EFL1 GFM1	5.86e-03	34	63	2	IPR020568
Domain	GPCR_2_secretin-like_CS	CELSR3 ADGRF3	5.86e-03	34	63	2	IPR017983
Domain	GPS	CELSR3 ADGRF3	6.20e-03	35	63	2	PF01825
Domain	ZF_CCHC	ERVK-6 ERVK-5	6.20e-03	35	63	2	PS50158
Domain	VWFC_1	DGCR2 VWC2	6.55e-03	36	63	2	PS01208
Domain	GPS	CELSR3 ADGRF3	6.55e-03	36	63	2	PS50221
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.84e-13	94	72	9	21542922
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	1.69e-11	4	72	4	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-5 ERVK-19 ERVK-10	1.69e-11	4	72	4	7983737
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.58e-11	12	72	5	14557543
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	8.43e-11	5	72	4	12629516
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	5.05e-08	18	72	4	18664271
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-5 ERVK-7	8.48e-08	5	72	3	11401426
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	1.69e-07	6	72	3	15063128
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.01e-06	10	72	3	12970426
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	4.23e-06	2	72	2	16521160
Pubmed	Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.	PADI3 PADI1	4.23e-06	2	72	2	15150696
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	4.23e-06	2	72	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	4.23e-06	2	72	2	9460924
Pubmed	Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells.	CYTH1 ARF6	4.23e-06	2	72	2	23517829
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	4.23e-06	2	72	2	19634011
Pubmed	Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.	CYTH1 ARF6	4.23e-06	2	72	2	20018626
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	4.23e-06	2	72	2	29948332
Pubmed	The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.	PADI3 PADI1	4.23e-06	2	72	2	16091842
Pubmed	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.	PADI3 PADI1	1.27e-05	3	72	2	33741961
Pubmed	Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.	PADI3 PADI1	1.27e-05	3	72	2	16973334
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	1.27e-05	3	72	2	10516026
Pubmed	Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.	PADI3 PADI1	1.27e-05	3	72	2	15675958
Pubmed	Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.	CYTH1 ARF6	1.27e-05	3	72	2	28780751
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	1.27e-05	3	72	2	9971820
Pubmed	HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.	CYTH1 ARF6	1.27e-05	3	72	2	30404949
Pubmed	Three types of mouse peptidylarginine deiminase: characterization and tissue distribution.	PADI3 PADI1	1.27e-05	3	72	2	1778991
Pubmed	Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.	PADI3 PADI1	1.27e-05	3	72	2	26616205
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DGCR2 CELSR3 MIB1 AKNA KAT6B CARNS1 SHISAL1 MED13	1.39e-05	529	72	8	14621295
Pubmed	Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain.	CELSR3 EDNRB SLC12A5	2.40e-05	27	72	3	19208226
Pubmed	De Novo Coding Variants Are Strongly Associated with Tourette Disorder.	CELSR3 FN1	2.53e-05	4	72	2	28472652
Pubmed	Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.	PADI3 PADI1	2.53e-05	4	72	2	27929094
Pubmed	Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.	PADI3 PADI1	2.53e-05	4	72	2	10092850
Pubmed	PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.	PADI3 PADI1	2.53e-05	4	72	2	14579251
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	2.53e-05	4	72	2	32830538
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	VWC2 DGAT2 TMPRSS6 HAPLN3 PAPLN ADGRF3 SLC35F5	4.75e-05	460	72	7	20562862
Pubmed	Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.	PADI3 PADI1	6.31e-05	6	72	2	15087120
Pubmed	Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.	CYTH1 ARF6	8.82e-05	7	72	2	23012656
Pubmed	The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.	CYTH1 ARF6	1.17e-04	8	72	2	17398095
Pubmed	FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.	CYTH1 ARF6	1.17e-04	8	72	2	20080746
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR3 SLIT1	1.51e-04	9	72	2	9693030
Pubmed	FRMD4A-cytohesin signaling modulates the cellular release of tau.	CYTH1 ARF6	1.51e-04	9	72	2	27044754
Pubmed	The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.	CYTH1 ARF6	1.51e-04	9	72	2	17846866
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CELSR3 CARNS1 MED13 BAHCC1	1.57e-04	130	72	4	12421765
Pubmed	Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.	ROCK2 SLIT1	2.30e-04	11	72	2	19210786
Pubmed	Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells.	ROCK2 AKT3	2.30e-04	11	72	2	21423810
Pubmed	Action of Actomyosin Contraction With Shh Modulation Drive Epithelial Folding in the Circumvallate Papilla.	FN1 EDNRB	2.30e-04	11	72	2	32848868
Pubmed	An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.	DGAT2 HAND1	2.75e-04	12	72	2	27731369
Pubmed	CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.	CYTH1 ARF6	2.75e-04	12	72	2	32873638
Pubmed	Expression of Slit and Robo genes in the developing mouse heart.	SLIT1 HAND1	3.25e-04	13	72	2	20941780
Pubmed	Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.	HAND1 EDNRB	3.78e-04	14	72	2	28067313
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DGCR2 TNRC18 CELSR3 PPRC1 CYTH1 AKNA PAPLN MED13 BAHCC1	4.51e-04	1105	72	9	35748872
Pubmed	Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.	FLT3 VAV1	4.98e-04	16	72	2	10022833
Pubmed	The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis.	FN1 HAND1	6.33e-04	18	72	2	21094155
Pubmed	Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube.	SLIT1 MIB1	6.33e-04	18	72	2	33892704
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	CYTH1 ARF6	7.06e-04	19	72	2	30674481
Pubmed	Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins.	FN1 EDNRB	7.06e-04	19	72	2	29196262
Pubmed	Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development.	FN1 HAND1	7.84e-04	20	72	2	21350214
Pubmed	Genetic dissection of the function of hindbrain axonal commissures.	SLIT1 GRID2	7.84e-04	20	72	2	20231872
Pubmed	AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.	FLT3 VAV1	9.50e-04	22	72	2	9811459
Pubmed	Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.	ROCK2 AKT3	1.04e-03	23	72	2	11086988
Pubmed	The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.	FN1 HAND1	1.13e-03	24	72	2	10021345
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	ACSM2A ACSM2B	1.23e-03	25	72	2	19372376
Pubmed	Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.	MIB1 HAND1	1.23e-03	25	72	2	17397913
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	CYTH1 ARF6	1.43e-03	27	72	2	29420262
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	CELSR3 ADGRF3	1.65e-03	29	72	2	15203201
Cytoband	16p12.3	XYLT1 ACSM2A ACSM2B	2.05e-05	34	71	3	16p12.3
Cytoband	7p22.1	ERVK-6 TNRC18	2.44e-03	47	71	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	XYLT1 ACSM2A ACSM2B	2.45e-03	172	71	3	chr16p12
Cytoband	Ensembl 112 genes in cytogenetic band chr10q24	ARL3 PPRC1 SLIT1	3.20e-03	189	71	3	chr10q24
Cytoband	1p36.13	PADI3 PADI1	3.44e-03	56	71	2	1p36.13
GeneFamily	Peptidyl arginine deiminases	PADI3 PADI1	5.76e-05	5	44	2	677
GeneFamily	Ferlin family	OTOF FER1L6	8.63e-05	6	44	2	828
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ROCK2 AKT3 CYTH1 ARHGAP9 VAV1	1.38e-04	206	44	5	682
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	1.81e-03	26	44	2	40
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	ARL3 ARF6	2.57e-03	31	44	2	357
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP9 ARHGAP39	6.58e-03	50	44	2	721
Coexpression	GSE32533_WT_VS_MIR17_KO_ACT_CD4_TCELL_DN	AKT3 CYTH1 MRPL51 KAT6B VAV1 MED13	7.95e-06	197	63	6	M8464
ToppCell	AT1-AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	TMPRSS6 HAND1 PAPLN TMC4 SHISAL1	2.99e-06	158	63	5	3bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCell	normal_Lymph_Node-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	FLT3 DGAT2 PLCD1 ADGRF3 ARF6	3.81e-06	166	63	5	6210a136efb99d70c2026b6454363f1bd2723558
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DGAT2 TMPRSS6 ACSM2A FER1L6 ACSM2B	7.34e-06	190	63	5	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 CYTH1 AKNA ARHGAP9 VAV1	8.75e-06	197	63	5	61ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRID2 ACSM2A FER1L6 ACSM2B	4.51e-05	139	63	4	a1945b07f177cde40e7eea03a19236ce76165857
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT3 DGAT2 AKNA ZNF114	5.76e-05	148	63	4	12fa2c4922f03803006c606b1b16e79441e3bb13
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT3 ARHGAP9 ADGRF3 VAV1	5.76e-05	148	63	4	3f48f5ba0a0928ddf6da7a1be1976933921f42ad
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|343B / Donor, Lineage, Cell class and subclass (all cells)	XYLT1 AMACR CYTH1 ARHGAP9	6.23e-05	151	63	4	78475027bba9e3026e42493fec8ea630972353bb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_endothelial_cell_-_unspecif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HAPLN3 CARNS1 ARF6	7.98e-05	161	63	4	2a721b6228045adb2dfbcd4990d371f961dc5dc2
ToppCell	Control-APC-like-Monocytes\|Control / group, cell type (main and fine annotations)	CLEC4A FUNDC2 C17orf78 ARHGAP9	8.37e-05	163	63	4	4bc80a2c741d462724b6f3902377d48c57478932
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CELSR3 AKNA ARHGAP9 VAV1	8.57e-05	164	63	4	649e42d9cfdec2f7771d1e938b516e46e7d07078
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CELSR3 AKNA ARHGAP9 VAV1	8.57e-05	164	63	4	ba85f7b21ae34e285d286ada24715885ca6329f7
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	XYLT1 CELSR3 HAPLN3 ZNF114	8.57e-05	164	63	4	d2218d50e0e2d19f919dcb460b3840687c082810
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 DGAT2 HAPLN3 PLCD1	9.63e-05	169	63	4	e3410ccb3f85811c75694e286115803911169a2f
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 DGAT2 HAPLN3 PLCD1	9.63e-05	169	63	4	a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCell	facs-Marrow-T_cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 ARL3 ADGRF3 EDNRB	9.63e-05	169	63	4	2a35846b0e0be0a19a5a04a86cbd72ce65257c8a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT3 AKNA ARHGAP9 VAV1	1.01e-04	171	63	4	39c8ae139e449217091e1481eb5e2aafb8f69a1c
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	XYLT1 OMA1 AKT3 FLT3	1.03e-04	172	63	4	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	droplet-Tongue-Unstain-18m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 AKNA HAPLN3 VAV1	1.08e-04	174	63	4	9019011eb8d9b7a95804fc11434f0fd42418103a
ToppCell	droplet-Tongue-Unstain-18m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 AKNA HAPLN3 VAV1	1.08e-04	174	63	4	deafbd0c2523afe09cc42f8c7b33945f3f5c00b4
ToppCell	droplet-Tongue-Unstain-18m-Myeloid\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 AKNA HAPLN3 VAV1	1.08e-04	174	63	4	f2eb0199f59e1e2f46da344c05289876bd254fa3
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3 OTOF DGAT2 VAV1	1.08e-04	174	63	4	6688424fc4e40c3c4a89669a2bc79369a726f1e6
ToppCell	metastatic_Brain-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	FLT3 DGAT2 PLCD1 ZNF114	1.08e-04	174	63	4	5ec8a48a390379d6c422120dce46437a77da67cc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 HAPLN3 SHISAL1 EDNRB	1.13e-04	176	63	4	ef0ff02897104e938c8a632357d8f1a6f014e68a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 HAPLN3 SHISAL1 EDNRB	1.13e-04	176	63	4	da0983929fa682a68e536c298a2d7add188b7563
ToppCell	normal_Lymph_Node-Myeloid_cells-CD141+_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	FLT3 DGAT2 PLCD1 BAHCC1	1.20e-04	179	63	4	ec995ccd6e1dbd06287ad836c232d9aed1cf94a8
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 VWC2 SHISAL1 EDNRB	1.23e-04	180	63	4	fa819df81fca95c2cc602fede635cb03e3f35fad
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 VWC2 SHISAL1 EDNRB	1.23e-04	180	63	4	907cd510fd2e21532ce04ba687e8894f7af71f27
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-1\|TCGA-Skin / Sample_Type by Project: Shred V9	FLT3 CLEC4A ARHGAP9 VAV1	1.31e-04	183	63	4	cd00e2cd901df4b3f5f7aed747cc0b47f6d3c811
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 VWC2 SHISAL1 EDNRB	1.34e-04	184	63	4	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	RSV-Healthy-5\|Healthy / Virus stimulation, Condition and Cluster	DGAT2 TMPRSS6 HAPLN3 TMC4	1.34e-04	184	63	4	1e282d619ef8035437fabe0fd2aefda1c142f7f6
ToppCell	RSV-Healthy-5\|RSV / Virus stimulation, Condition and Cluster	DGAT2 TMPRSS6 HAPLN3 TMC4	1.34e-04	184	63	4	ba958f731de6c9eff60103d483e020e2c0c7af7c
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 VWC2 SHISAL1 EDNRB	1.34e-04	184	63	4	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 OTOF GRID2 SHISAL1	1.39e-04	186	63	4	96f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 OTOF GRID2 SHISAL1	1.42e-04	187	63	4	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	tumor_Lung-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	FLT3 DGAT2 PLCD1 ARF6	1.45e-04	188	63	4	9874ba56bf6a0d509cccc89563dbf1395e17e84e
ToppCell	LAM-Myeloid-DC\|LAM / Condition, Lineage and Cell class	FLT3 CLEC4A ARHGAP9 SLC12A5	1.45e-04	188	63	4	b4140110c2f7d25fd8a0d2749e33e02003ac4bf2
ToppCell	wk_08-11-Hematologic-Myeloid-Promonocyte-like\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FLT3 CLEC4A ARHGAP9 VAV1	1.45e-04	188	63	4	2ae945d96a011f246d04a42bcd6ef443232b03f4
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	XYLT1 AKT3 AKNA HELB	1.48e-04	189	63	4	df30478b288084a1bd48f660409dcc784040897c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VWC2 FLT3 AKNA SHISAL1	1.51e-04	190	63	4	26843ec1d19ac85a50990705353b802745d33e4d
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FN1 ACSM2A EDNRB ACSM2B	1.51e-04	190	63	4	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	Dendritic_Cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	XYLT1 FLT3 AKNA SLC12A5	1.54e-04	191	63	4	b51c8ff1279581088557bb36760c70209c77148c
ToppCell	Adult-Immune-T_lymphocyte-D175\|Adult / Lineage, Cell type, age group and donor	XYLT1 AKT3 AKNA HELB	1.54e-04	191	63	4	0b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FLT3 TSGA10IP TARBP1 BAHCC1	1.57e-04	192	63	4	38ec82aa2ec4f2c0a843e83f7fe54f6b2483ca3d
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FN1 ACSM2A EDNRB ACSM2B	1.57e-04	192	63	4	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 OTOF GRID2 SHISAL1	1.60e-04	193	63	4	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 OTOF GRID2 SHISAL1	1.60e-04	193	63	4	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	HAPLN3 SHISAL1 EDNRB ACSM2B	1.64e-04	194	63	4	8a4be91414a2e69dd410aa75791f16008204c9a1
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 OTOF GRID2 SHISAL1	1.64e-04	194	63	4	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AKNA ARHGAP9 KAT6B ARF6	1.67e-04	195	63	4	0a72b8446399807ace5b6c72f865bb40dbd9e92d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial-Astrocyte\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	OTOF HAPLN3 PLCD1 EDNRB	1.70e-04	196	63	4	55a10faafcbe075eefdfcd7cff25ded040c23538
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	OTOF HAPLN3 PLCD1 EDNRB	1.70e-04	196	63	4	8025ec8aee8455c7b0261aa4a0caacebd2f50634
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT3 CLEC4A ARHGAP9 VAV1	1.70e-04	196	63	4	a692cee9254f3771a076b290688a4d0120c02c3b
ToppCell	distal-Epithelial-Goblet\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMC4 EPS8L1 FER1L6 PADI3	1.74e-04	197	63	4	da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	FLT3 FAHD2B PLCD1 SLC12A5	1.74e-04	197	63	4	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLT3 BCL2L10 TMC4 TSGA10IP	1.74e-04	197	63	4	8fa38fb95e285f9cc756ec4f32009be4ede09d3c
ToppCell	distal-Epithelial-Goblet-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMC4 EPS8L1 FER1L6 PADI3	1.74e-04	197	63	4	3fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLT3 DGAT2 PLCD1 ARF6	1.77e-04	198	63	4	e1df453729ec565f1a55a6c649e87aa9e0c5cacf
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLT3 DGAT2 PLCD1 ARF6	1.77e-04	198	63	4	2cfdcbf33854f314c41ea0f01c31bc27b66c2f91
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLT3 BCL2L10 TMC4 TSGA10IP	1.77e-04	198	63	4	436f3a9ef31b0991765bb97c21960f20fa71d578
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-T_reg\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR3 HAPLN3 VAV1 HELB	1.77e-04	198	63	4	7608f67959e1cda7b10e57fd3af2f96216ebe7e9
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMC4 EPS8L1 FER1L6 PADI1	1.80e-04	199	63	4	7223f853335492ca617dbec3e4b6872a8a463a45
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMC4 EPS8L1 FER1L6 PADI1	1.80e-04	199	63	4	e03bdc7cb825e287f41b834ec6061d23c1c03b04
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLT3 TMC4 TSGA10IP TARBP1	1.84e-04	200	63	4	6a34e07e6d77fe3fdd9ff44c4b1e46a023f6d6a2
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKT3 FN1 HAPLN3 GRID2	1.84e-04	200	63	4	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKT3 VAV1 HELB	1.84e-04	200	63	4	cded40d5069a6fdbd90ac9a2a0bbef11727b28d5
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKNA ARHGAP9 VAV1	1.84e-04	200	63	4	7d90fcb5dfc4c9d562c93b0f9293ed12b5f4f404
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKNA ARHGAP9 VAV1	1.84e-04	200	63	4	d2422aaf807010194994db97142b9fd2e807312d
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKT3 VAV1 HELB	1.84e-04	200	63	4	e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKNA VAV1 HELB	1.84e-04	200	63	4	c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKNA VAV1 HELB	1.84e-04	200	63	4	9de4d6ebb7e9bee5d811519eb05913ef30f70786
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKNA VAV1 HELB	1.84e-04	200	63	4	f7a9d8b99de19e9842422bada348d940e0863645
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 AKNA ARHGAP9 VAV1	1.84e-04	200	63	4	1d2ee63010b7b8b38bea7d3b30eebfbcdd18b967
Drug	Bromperidol [10457-90-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A	DGCR2 AKT3 FN1 BCL2L10 TMPRSS6 HAND1 SHISAL1 BAHCC1	7.70e-08	193	65	8	2872_UP
Drug	Dimethadione [695-53-4]; Down 200; 31uM; MCF7; HT_HG-U133A	AMACR CYTH1 EPS8L1 VAV1 PADI1 SLC12A5 BAHCC1	1.49e-06	197	65	7	5668_DN
Drug	Isoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	DGCR2 FN1 BCL2L10 TMPRSS6 PLCD1 PADI1 SLC35F5	1.49e-06	197	65	7	1485_UP
Drug	AC1L3X7J	AVPR1B PPRC1 VAV1	4.80e-06	12	65	3	CID000123741
Drug	Bq123	ROCK2 FN1 BCL2L10 PPRC1 EDNRB	7.71e-06	95	65	5	CID000443289
Drug	Letrozole [112809-51-5]; Up 200; 14uM; HL60; HT_HG-U133A	FLT3 CELSR3 FN1 BCL2L10 AVPR1B AMACR	1.47e-05	185	65	6	2916_UP
Drug	Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Down 200; 5.8uM; MCF7; HT_HG-U133A	DGCR2 LMF2 EPS8L1 PADI3 PADI1 BAHCC1	2.04e-05	196	65	6	6846_DN
Drug	Guanabenz acetate [23256-50-0]; Up 200; 13.8uM; MCF7; HT_HG-U133A	DGCR2 CYTH1 PLCD1 EPS8L1 PADI1 BAHCC1	2.16e-05	198	65	6	1544_UP
Disease	X-21319 measurement	ACSM2A ACSM2B	4.20e-06	2	61	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	1.26e-05	3	61	2	EFO_0021242
Disease	non-alcoholic fatty liver disease	AKNA TMC4 ACSM2A TARBP1 ACSM2B	3.80e-05	182	61	5	EFO_0003095
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	4.19e-05	5	61	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	6.27e-05	6	61	2	EFO_0800106
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	OTOF FER1L6	8.77e-05	7	61	2	DOID:11724 (implicated_via_orthology)
Disease	Tourette syndrome	XYLT1 EFL1 FLT3	1.54e-04	50	61	3	EFO_0004895
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DIP2B MED13	5.60e-04	17	61	2	DOID:0060307 (is_implicated_in)
Disease	alcohol use disorder (implicated_via_orthology)	AKT3 EPS8L1 ADGRF3 ARF6	7.19e-04	195	61	4	DOID:1574 (implicated_via_orthology)
Disease	blood tin measurement	OMA1 SLIT1	1.22e-03	25	61	2	EFO_0021530
Disease	aspartate aminotransferase to alanine aminotransferase ratio	DIP2B AKNA ARHGAP9 ARHGAP39	1.53e-03	239	61	4	EFO_0010934
Disease	bipolar disorder (is_implicated_in)	AVPR1B KAT6B	1.65e-03	29	61	2	DOID:3312 (is_implicated_in)
Disease	Hirschsprung Disease	CELSR3 EDNRB	1.88e-03	31	61	2	C0019569

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQLWKWSGNPTQRRG	BAHCC1	2481	Q9P281
RVKPGGRWREAAWQL	B3GALT6	191	Q96L58
QRRQWGPLIGRDKAW	ADGRF3	41	Q8IZF5
ARWKKWGFQPRLKEQ	BCL2L10	116	Q9HD36
WKTQKLSLWEAPRGQ	AMACR	196	Q9UHK6
GKRLPSPALWWVNGK	ACSM2A	61	Q08AH3
WRNIVDQIWSFGPRK	EFL1	816	Q7Z2Z2
WDIGGQRKIRPYWKN	ARL3	66	P36405
LWRWQKKGGQPPGTA	C17orf78	226	Q8N4C9
QVAVKLSGWRWRGRQ	CARNS1	161	A5YM72
WSRIKGIGVPKWTAV	EDNRB	206	P24530
PWKRKIINNVTDGWK	C6orf201	61	Q7Z4U5
WVQKRGEYIKNWRPR	AKT3	11	Q9Y243
GTNVRRKPFPFKWWN	PADI1	646	Q9ULC6
PAGVRIKRTSENQWW	ARHGAP39	56	Q9C0H5
QVWPKGTKRGLSKWR	KAT6B	1246	Q8WYB5
TNKWKNIPCSWVGRI	nan	796	O00370
PRRVRVKWWKLSENG	HAPLN3	81	Q96S86
LETWWNKRKGSRVPS	GRID2	851	O43424
GGGRVKTWKRRWFIL	CYTH1	271	Q15438
IVQFKGWPRLKWVVT	DIP2B	476	Q9P265
KRIKGRTGWPQQVWA	HAND1	196	O96004
RNFVDKRQWVWGPSG	PADI3	131	Q9ULW8
ARVVRGPDWKWGKQD	MIB1	16	Q86YT6
AQGPWWARKRLNIRV	PLCD1	621	P51178
GVWNRKANRKVFGQW	FLT3	481	P36888
GRKGNIIPLTVWNDW	ERVK-10	71	P87889
GRKGNIIPLTVWNDW	ERVK-19	71	Q9YNA8
GRKGNIIPLTVWNDW	ERVK-21	71	P62683
GRKGNIIPLTVWNDW	ERVK-24	71	P63145
GRKGNIIPLTVWNDW	ERVK-5	71	Q9HDB9
GRKGNIIPLTVWNDW	ERVK-6	71	Q7LDI9
GRKGNIIPLTVWNDW	ERVK-7	71	P63130
GRKGNIIPLTVWNDW	ERVK-8	71	P62685
GRKGNIIPLTVWNDW	ERVK-9	71	P63126
GRKGNIIPLTVWNDW	HERVK_113	71	P62684
WLTRRNGKQWLLGKT	FAHD2B	196	Q6P2I3
YILRWRPKNSVGRWK	FN1	641	P02751
GKGPQRRRWAWAEDK	AKNA	16	Q7Z591
WAKEGQGTKKPWRFL	CFAP100	316	Q494V2
QPERSFGWKDQRKLW	DGCR2	171	P98153
KSLRSGVWWPQTKFG	CELSR3	2131	Q9NYQ7
SRKWWKVRDPAGQEG	EPS8L1	511	Q8TE68
RAPASLGWQRKQVNW	GFM1	16	Q96RP9
QGKGKPRAWARAWAA	PPRC1	516	Q5VV67
PITGAWWRVKVQVKP	HELB	81	Q8NG08
WWRVKVQVKPVVGSR	HELB	86	Q8NG08
TPKKGGRRSQWVRNW	DGAT2	116	Q96PD7
PLVSIFKQKRVKGWW	OTOF	1876	Q9HC10
HNTVLVGWPRNWRQK	SLC12A5	791	Q9H2X9
KKQPWWRKLFGQESG	FUNDC2	61	Q9BWH2
KISIFQQKRVRGWWP	FER1L6	1741	Q2WGJ9
QQKRVRGWWPFSKSK	FER1L6	1746	Q2WGJ9
QWRKTRAKELQGPWD	TSGA10IP	306	Q3SY00
WKPWRQQCTRGLRGK	SLC35F5	121	Q8WV83
LRPQGKGRWQQLWET	LMF2	46	Q9BU23
GIQGRWMKQDPRRWG	SHISAL1	136	Q3SXP7
KRTVRPWGVQGPLTW	MED13	1296	Q9UHV7
GRGIRKWWQALPPNK	OMA1	166	Q96E52
GRKGNIIPLTVWNDW	ERVK-9	71	P63128
GKRLPSPALWWVNGK	ACSM2B	61	Q68CK6
VWDVGGQDKIRPLWR	ARF6	61	P62330
LNFRKSPKRWGWNDV	CLEC4A	206	Q9UMR7
QLWKWFGKPTQRRGM	TNRC18	2786	O15417
GREPWSKLKQAWVSQ	VWC2	86	Q2TAL6
KVKTQAWRVGGGGWR	AVPR1B	231	P47901
KWGKGPNVTVTVIWV	XYLT1	771	Q86Y38
AVQRKPWPSGGLWRQ	PAPLN	846	O95428
KELIRGPIWLRGWKG	MRPL51	71	Q4U2R6
GPIWLRGWKGNELQR	MRPL51	76	Q4U2R6
SLQPWAWTLKRIGGQ	TMC4	141	Q7Z404
ILNKKGQQGWWRGEI	VAV1	811	P15498
WLSLPVRNNTKKFGW	ROCK2	1156	O75116
QGGRKLRKNWGPSWV	ARHGAP9	336	Q9BRR9
LRKNWGPSWVVLTGN	ARHGAP9	341	Q9BRR9
LKVGWKRGNPIWRVI	TARBP1	766	Q13395
WLGGWLRKRKIVTGN	SLIT1	681	O75093
WRGSVAILQKWLKGR	TGM6	251	O95932
TVFLGKVWQNSRWPG	TMPRSS6	631	Q8IU80
GWNIQWVPCGRKTEL	ZNF114	181	Q8NC26