Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activator activity	DAB2IP DBF4B TOPBP1 DDX3X	6.78e-05	78	56	4	GO:0043539
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	1.15e-04	6	56	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	2.14e-04	8	56	2	GO:0032453
GeneOntologyMolecularFunction	phosphorylation-dependent protein binding	ANK2 TOPBP1	3.43e-04	10	56	2	GO:0140031
GeneOntologyMolecularFunction	protein kinase activator activity	DAB2IP DBF4B TOPBP1 DDX3X	8.09e-04	149	56	4	GO:0030295
GeneOntologyMolecularFunction	cytoskeletal protein binding	CLIP3 ANK2 ABI3BP INF2 MYO7B STXBP5 CTNNA3 KIF13A FMNL1 DDX3X	8.62e-04	1099	56	10	GO:0008092
GeneOntologyMolecularFunction	kinase activator activity	DAB2IP DBF4B TOPBP1 DDX3X	1.03e-03	159	56	4	GO:0019209
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase binding	DAB2IP KSR1	1.28e-03	19	56	2	GO:0031434
GeneOntologyBiologicalProcess	regulation of cell cycle process	DAB2IP ATRIP DBF4B PKD1 MKI67 TOPBP1 WEE2 SIN3A KIF13A ATP2B4 DDX3X	1.17e-05	845	55	11	GO:0010564
GeneOntologyCellularComponent	trans-Golgi network	CLIP3 ATXN2 HLA-DPB1 GRN ATP9A KIF13A	1.64e-04	306	56	6	GO:0005802
GeneOntologyCellularComponent	trans-Golgi network membrane	CLIP3 HLA-DPB1 ATP9A KIF13A	2.31e-04	112	56	4	GO:0032588
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	5.28e-05	4	56	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	5.28e-05	4	56	2	PF08429
Domain	FHA	CEP170 MKI67 KIF13A	7.93e-05	28	56	3	SM00240
Domain	zf-C5HC2	KDM5C KDM5D	8.78e-05	5	56	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	8.78e-05	5	56	2	IPR004198
Domain	FHA_DOMAIN	CEP170 MKI67 KIF13A	1.08e-04	31	56	3	PS50006
Domain	FHA	CEP170 MKI67 KIF13A	1.08e-04	31	56	3	PF00498
Domain	FHA_dom	CEP170 MKI67 KIF13A	1.70e-04	36	56	3	IPR000253
Domain	-	CEP170 MKI67 KIF13A	1.70e-04	36	56	3	2.60.200.20
Domain	Drf_GBD	INF2 FMNL1	3.14e-04	9	56	2	PF06371
Domain	FH3_dom	INF2 FMNL1	3.14e-04	9	56	2	IPR010472
Domain	GTPase-bd	INF2 FMNL1	3.14e-04	9	56	2	IPR010473
Domain	Drf_FH3	INF2 FMNL1	3.14e-04	9	56	2	PF06367
Domain	Drf_FH3	INF2 FMNL1	3.14e-04	9	56	2	SM01139
Domain	Drf_GBD	INF2 FMNL1	3.14e-04	9	56	2	SM01140
Domain	JmjN	KDM5C KDM5D	3.91e-04	10	56	2	SM00545
Domain	JMJN	KDM5C KDM5D	3.91e-04	10	56	2	PS51183
Domain	JmjN	KDM5C KDM5D	3.91e-04	10	56	2	PF02375
Domain	JmjN	KDM5C KDM5D	3.91e-04	10	56	2	IPR003349
Domain	GBD/FH3_dom	INF2 FMNL1	4.77e-04	11	56	2	IPR014768
Domain	GBD_FH3	INF2 FMNL1	4.77e-04	11	56	2	PS51232
Domain	SMAD_FHA_domain	CEP170 MKI67 KIF13A	5.08e-04	52	56	3	IPR008984
Domain	-	KDM5C KDM5D	9.04e-04	15	56	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	9.04e-04	15	56	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	9.04e-04	15	56	2	IPR001606
Domain	ARID	KDM5C KDM5D	9.04e-04	15	56	2	PS51011
Domain	ARID	KDM5C KDM5D	9.04e-04	15	56	2	PF01388
Domain	FH2	INF2 FMNL1	9.04e-04	15	56	2	PS51444
Domain	FH2_Formin	INF2 FMNL1	9.04e-04	15	56	2	IPR015425
Domain	FH2	INF2 FMNL1	9.04e-04	15	56	2	PF02181
Domain	FH2	INF2 FMNL1	9.04e-04	15	56	2	SM00498
Domain	-	DBF4B TOPBP1	2.15e-03	23	56	2	3.40.50.10190
Domain	JmjC	KDM5C KDM5D	2.34e-03	24	56	2	PF02373
Domain	BRCT	DBF4B TOPBP1	2.74e-03	26	56	2	PS50172
Domain	DEATH	ANK2 TNFRSF21	2.95e-03	27	56	2	SM00005
Domain	BRCT_dom	DBF4B TOPBP1	3.17e-03	28	56	2	IPR001357
Domain	JMJC	KDM5C KDM5D	4.13e-03	32	56	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	4.13e-03	32	56	2	IPR003347
Domain	JmjC	KDM5C KDM5D	4.39e-03	33	56	2	SM00558
Domain	Death	ANK2 TNFRSF21	4.39e-03	33	56	2	PF00531
Domain	ATPase_P-typ_cyto_domN	ATP9A ATP2B4	4.93e-03	35	56	2	IPR023299
Domain	P_typ_ATPase	ATP9A ATP2B4	5.21e-03	36	56	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP9A ATP2B4	5.21e-03	36	56	2	IPR018303
Domain	ATPASE_E1_E2	ATP9A ATP2B4	5.21e-03	36	56	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP9A ATP2B4	5.50e-03	37	56	2	IPR008250
Domain	E1-E2_ATPase	ATP9A ATP2B4	5.50e-03	37	56	2	PF00122
Domain	Death_domain	ANK2 TNFRSF21	5.79e-03	38	56	2	IPR000488
Domain	DEATH_DOMAIN	ANK2 TNFRSF21	5.79e-03	38	56	2	PS50017
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	ATRIP TOPBP1 PALB2	2.79e-04	43	42	3	M27588
Pathway	PID_FANCONI_PATHWAY	ATRIP TOPBP1 PALB2	3.64e-04	47	42	3	M1
Pathway	REACTOME_DISEASES_OF_DNA_REPAIR	ATRIP TOPBP1 PALB2	4.64e-04	51	42	3	M29854
Pathway	WP_ATR_SIGNALING	ATRIP TOPBP1	4.69e-04	11	42	2	M39507
Pathway	KEGG_MEDICUS_VARIANT_TEL_AML1_FUSION_TO_TRANSCRIPTIONAL_REPRESSION	NCOR1 SIN3A	4.69e-04	11	42	2	M47438
Pathway	KEGG_MEDICUS_REFERENCE_ATR_SIGNALING	ATRIP TOPBP1	5.61e-04	12	42	2	M47841
Pathway	REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME	NCOR1 SIN3A	6.62e-04	13	42	2	M29766
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PACS1 NCOR1 RNPS1 KDM5C MKI67 ZNF217 SIN3A SRRM2 REXO1 PALB2	3.97e-07	774	56	10	15302935
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	2.55e-06	2	56	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	2.55e-06	2	56	2	16416087
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	2.55e-06	2	56	2	32081420
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	2.55e-06	2	56	2	9060413
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	2.55e-06	2	56	2	7524912
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM5C KDM5D DDX3X	3.17e-06	18	56	3	12023983
Pubmed	Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.	MKI67 TOPBP1 DDX3X	3.17e-06	18	56	3	35762573
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DAB2IP CLIP3 SBF1 STXBP5 CTNNA3 ATP9A SPECC1	5.79e-06	430	56	7	32581705
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	NCOR1 SUPT20H RNPS1 MKI67 TOPBP1 EI24 SIN3A ZFC3H1 SRRM2 PALB2 DDX3X	5.79e-06	1294	56	11	30804502
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	INF2 RBM33 ZFC3H1 SRRM2 DDX3X	6.70e-06	163	56	5	22113938
Pubmed	Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.	KDM5C MKI67 DDX3X	6.84e-06	23	56	3	22573614
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	7.63e-06	3	56	2	7544442
Pubmed	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.	ATRIP TOPBP1	7.63e-06	3	56	2	18519640
Pubmed	A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.	NCOR1 SIN3A	7.63e-06	3	56	2	9139820
Pubmed	TopBP1 activates the ATR-ATRIP complex.	ATRIP TOPBP1	7.63e-06	3	56	2	16530042
Pubmed	ATR autophosphorylation as a molecular switch for checkpoint activation.	ATRIP TOPBP1	7.63e-06	3	56	2	21777809
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP170 KSR1 SBF1 EXPH5 KIF13A SRRM2 SPECC1 FGD6 DDX3X	8.95e-06	861	56	9	36931259
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CEP170 NCOR1 ATXN2 RBM33 MKI67 ZNF217 SIN3A SRRM2 PALB2 DDX3X	9.35e-06	1103	56	10	34189442
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	CEP170 NCOR1 MKI67 GRN ZNF217	1.20e-05	184	56	5	32908313
Pubmed	Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.	NCOR1 SIN3A	1.52e-05	4	56	2	10441327
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	1.52e-05	4	56	2	16541399
Pubmed	The Ski protein family is required for MeCP2-mediated transcriptional repression.	NCOR1 SIN3A	1.52e-05	4	56	2	11441023
Pubmed	Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.	MKI67 SIN3A	1.52e-05	4	56	2	27399968
Pubmed	Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.	ATRIP TOPBP1	1.52e-05	4	56	2	17616665
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	1.52e-05	4	56	2	17320160
Pubmed	Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation.	ATRIP TOPBP1	1.52e-05	4	56	2	30940728
Pubmed	Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.	ATRIP TOPBP1	1.52e-05	4	56	2	17686975
Pubmed	The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.	ATRIP TOPBP1	1.52e-05	4	56	2	21693576
Pubmed	Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.	NCOR1 SIN3A	1.52e-05	4	56	2	9139821
Pubmed	HCLK2 is required for activity of the DNA damage response kinase ATR.	ATRIP TOPBP1	1.52e-05	4	56	2	19097996
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	1.52e-05	4	56	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	1.52e-05	4	56	2	7951230
Pubmed	TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.	NCOR1 SIN3A	1.52e-05	4	56	2	11439334
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	DAB2IP NCOR1 KDM5C MKI67 TOPBP1 KIF13A SRRM2	1.60e-05	503	56	7	16964243
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DAB2IP CEP170 NCOR1 ANK2 SBF1 ATXN2 ATF6B ATP2B4 DDX3X	2.17e-05	963	56	9	28671696
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	ANK2 ATXN2 MKI67 SIN3A	2.19e-05	101	56	4	26949739
Pubmed	A genome-wide association study (GWAS) for bronchopulmonary dysplasia.	CEP170 STXBP5 CTNNA3	2.28e-05	34	56	3	23897914
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	ATXN2 RBM33 SIN3A	2.49e-05	35	56	3	24515614
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	RNPS1 MRPS18B MKI67 ZFC3H1 SRRM2 SPECC1	2.52e-05	361	56	6	30344098
Pubmed	Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.	NCOR1 SIN3A	2.54e-05	5	56	2	16227606
Pubmed	Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines.	NCOR1 SIN3A	2.54e-05	5	56	2	12634383
Pubmed	Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.	NCOR1 SIN3A	2.54e-05	5	56	2	15729358
Pubmed	Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression.	NCOR1 SIN3A	2.54e-05	5	56	2	12466959
Pubmed	ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.	RNPS1 SIN3A SRRM2 DDX3X	2.75e-05	107	56	4	20508642
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	SUPT20H RBM33 TOPBP1 ZFC3H1 REXO1	2.97e-05	222	56	5	37071664
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	DAB2IP PACS1 ANK2 EXPH5 SPECC1 FGD6 ATP2B4	3.50e-05	569	56	7	30639242
Pubmed	Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.	MKI67 PALB2	3.80e-05	6	56	2	21404276
Pubmed	Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.	PACS1 PKD1	3.80e-05	6	56	2	15692563
Pubmed	Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease.	PKD1 MKI67	3.80e-05	6	56	2	30799240
Pubmed	Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.	NCOR1 SIN3A	3.80e-05	6	56	2	14761981
Pubmed	Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.	PKD1 MKI67	3.80e-05	6	56	2	20181743
Pubmed	Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.	NCOR1 SIN3A	3.80e-05	6	56	2	10640275
Pubmed	Functional proteomics mapping of a human signaling pathway.	NCOR1 EXPH5 PKD1 GRN KIF13A FMNL1 DDX3X	4.45e-05	591	56	7	15231748
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	KDM5C MKI67 SRRM2 PALB2 DDX3X	5.22e-05	250	56	5	33536335
Pubmed	Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.	RNPS1 PKD1	5.32e-05	7	56	2	8828041
Pubmed	Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.	NCOR1 SIN3A	5.32e-05	7	56	2	17182846
Pubmed	The Role of Epithelial Stat3 in Amelogenesis during Mouse Incisor Renewal.	ENAM MKI67	5.32e-05	7	56	2	29550820
Pubmed	Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.	NCOR1 SIN3A	5.32e-05	7	56	2	17956988
Pubmed	HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.	NCOR1 SIN3A	5.32e-05	7	56	2	11486045
Pubmed	Pkd1 is required for male reproductive tract development.	PKD1 MKI67	5.32e-05	7	56	2	23933588
Pubmed	SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway.	ATRIP TOPBP1	5.32e-05	7	56	2	24990965
Pubmed	Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.	NCOR1 SIN3A	5.32e-05	7	56	2	17210713
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	DAB2IP PACS1 SBF1 INF2 SPECC1 ATP2B4	5.91e-05	421	56	6	36976175
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	CEP170 INF2 MKI67 GRN SRRM2 SPECC1 DDX3X	6.39e-05	626	56	7	33644029
Pubmed	Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.	NCOR1 SIN3A	7.09e-05	8	56	2	10049357
Pubmed	DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.	NCOR1 SIN3A	7.09e-05	8	56	2	14525983
Pubmed	Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.	NCOR1 SIN3A	7.09e-05	8	56	2	20935208
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	NCOR1 SIN3A	7.09e-05	8	56	2	23770565
Pubmed	CoREST is an integral component of the CoREST- human histone deacetylase complex.	ZNF217 SIN3A	7.09e-05	8	56	2	11171972
Pubmed	Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.	NCOR1 SIN3A	7.09e-05	8	56	2	11430826
Pubmed	CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.	CLIP3 TNFRSF21	7.09e-05	8	56	2	22297296
Pubmed	ATRIP protects progenitor cells against DNA damage in vivo.	ATRIP MKI67	7.09e-05	8	56	2	33110058
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NCOR1 RBM33 RNPS1 ZNF217 SIN3A	7.25e-05	268	56	5	33640491
Pubmed	Human transcription factor protein interaction networks.	NCOR1 SUPT20H ATXN2 RBM33 MRPS18B MKI67 GRN ZNF217 SIN3A SRRM2	8.43e-05	1429	56	10	35140242
Pubmed	CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.	NCOR1 SIN3A DDX3X	8.75e-05	53	56	3	34026424
Pubmed	Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.	NCOR1 SIN3A	9.10e-05	9	56	2	10944117
Pubmed	SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.	NCOR1 SIN3A	9.10e-05	9	56	2	9702189
Pubmed	An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.	NCOR1 SIN3A	9.10e-05	9	56	2	12007404
Pubmed	Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression.	NCOR1 SIN3A	9.10e-05	9	56	2	24821727
Pubmed	Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1.	NCOR1 SIN3A	9.10e-05	9	56	2	19244234
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	POGLUT3 FBLN2 SBF1 ATXN2 INF2 RBM33 MRPS18B GRN SIN3A DDX3X	9.56e-05	1451	56	10	30550785
Pubmed	The functional interactome landscape of the human histone deacetylase family.	NCOR1 MKI67 ZNF217 SIN3A SRRM2	1.03e-04	289	56	5	23752268
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	RNPS1 SRRM2 FMNL1 DDX3X	1.14e-04	154	56	4	16055720
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	ANK2 MKI67	1.14e-04	10	56	2	22159418
Pubmed	Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number.	ENAM MKI67	1.14e-04	10	56	2	18156176
Pubmed	The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.	NCOR1 SIN3A	1.14e-04	10	56	2	11931768
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ATXN2 RBM33 RNPS1 MKI67 EI24 GRN SIN3A ZFC3H1 SRRM2	1.21e-04	1203	56	9	29180619
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SUPT20H SBF1 ATXN2 RBM33 MRPS18B TOPBP1 ZNF217 ZFC3H1 ATP9A SPECC1	1.24e-04	1497	56	10	31527615
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CEP170 NCOR1 ATXN2 RBM33 MKI67 TOPBP1 SRRM2 DDX3X	1.38e-04	954	56	8	36373674
Pubmed	MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.	MBD3L1 SIN3A	1.39e-04	11	56	2	15456747
Pubmed	The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.	NCOR1 KDM5C	1.39e-04	11	56	2	17468742
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	CEP170 ATXN2 RNPS1 MRPS18B MKI67 SRRM2 DDX3X	1.43e-04	713	56	7	29802200
Pubmed	Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.	MKI67 KIF13A	1.66e-04	12	56	2	32044971
Pubmed	Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.	INF2 KIF13A	1.66e-04	12	56	2	37143315
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CEP170 ATXN2 RNPS1 MRPS18B EXPH5 MKI67 ZFC3H1 SPECC1 DDX3X	1.68e-04	1257	56	9	36526897
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	CEP170 ANK2 SPECC1	1.76e-04	67	56	3	29254152
Pubmed	Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.	NCOR1 SIN3A	1.96e-04	13	56	2	16469706
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	1.96e-04	13	56	2	14660691
Pubmed	Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha).	MKI67 LCT	1.96e-04	13	56	2	9494081
Interaction	CSNK2A1 interactions	CEP170 PACS1 NCOR1 ATXN2 INF2 RBM33 RNPS1 KDM5C ZNF217 SIN3A ZFC3H1 SRRM2 DDX3X	1.29e-06	956	55	13	int:CSNK2A1
Interaction	SLX4 interactions	NCOR1 SUPT20H RBM33 MKI67 TOPBP1 ZFC3H1 SPECC1 REXO1 DDX3X	2.23e-05	572	55	9	int:SLX4
Interaction	PPP1CC interactions	NCOR1 INF2 RNPS1 MRPS18B MKI67 TOPBP1 ZFC3H1 SRRM2 SPECC1 DDX3X	2.68e-05	738	55	10	int:PPP1CC
Cytoband	20q13.2	ZNF217 ATP9A	5.03e-04	27	56	2	20q13.2
Cytoband	13q13.3	CCDC169 SUPT20H	5.81e-04	29	56	2	13q13.3
Cytoband	11q22.3	POGLUT3 EXPH5	1.34e-03	44	56	2	11q22.3
Cytoband	17q21	DBF4B FMNL1	2.72e-03	63	56	2	17q21
Cytoband	16p13.3	RNPS1 PKD1 SRRM2	3.34e-03	244	56	3	16p13.3
Cytoband	6p21.3	HLA-DPB1 MRPS18B ATF6B	3.57e-03	250	56	3	6p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr13q13	CCDC169 SUPT20H	4.56e-03	82	56	2	chr13q13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	POGLUT3 EXPH5	7.63e-03	107	56	2	chr11q22
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	3.98e-04	15	36	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	1.03e-03	24	36	2	485
Coexpression	GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_DP_THYMOCYTES_UP	ANK2 ABI3BP FAM220A ATP9A FGD6 ATP2B4	4.08e-06	198	56	6	M7550
Coexpression	GSE7852_LN_VS_THYMUS_TREG_UP	PACS1 SUPT20H EI24 KDM5D KIF13A FGD6	4.33e-06	200	56	6	M5737
Coexpression	GSE6092_B_BURGDOFERI_VS_B_BURGDORFERI_AND_IFNG_STIM_ENDOTHELIAL_CELL_UP	POGLUT3 INF2 EI24 SPECC1 FMNL1	3.73e-05	176	56	5	M6716
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_PULMONARY_NE_PRECURSOR_CELL	CLIP3 ANK2 APLP1 SPECC1 TNFRSF21 REXO1	4.62e-05	304	56	6	M45711
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FBLN2 HLA-DPB1 MKI67 SPECC1 TNFRSF21	2.59e-06	173	56	5	a55f310c533432e9e26e400026a5b47245152976
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 MKI67 SPECC1 TNFRSF21	2.59e-06	173	56	5	9c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DPB1 SPECC1 FGD6 REXO1 FMNL1	3.31e-06	182	56	5	4a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DPB1 SPECC1 FGD6 REXO1 FMNL1	3.31e-06	182	56	5	53213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DPB1 SPECC1 FGD6 REXO1 FMNL1	3.31e-06	182	56	5	7909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-DC2\|bone_marrow / Manually curated celltypes from each tissue	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	3.40e-06	183	56	5	f482e4fe011fa450a475034b1e25587233855bdb
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENAM CLIP3 FBLN2 ABI3BP LCT	3.40e-06	183	56	5	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	mild-Myeloid-mDC\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	3.49e-06	184	56	5	8b37c00d59d9992d3b43268991da7bb94646c70e
ToppCell	PBMC-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	4.87e-06	197	56	5	22e4ffb5de483eaf78f14badf3d08db898e3b3dd
ToppCell	PBMC-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	4.87e-06	197	56	5	346974c6c5809a3fe88cbf067e2d64c340310a31
ToppCell	PBMC-Severe-Myeloid-cDC-cDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	4.87e-06	197	56	5	1ae45c1ec3b3f88e0c1f99de58c58b1ec1b968ee
ToppCell	COVID-19_Severe-Myeloid-cDC\|COVID-19_Severe / Disease group, lineage and cell class	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	4.87e-06	197	56	5	843b0f1cc26864ee635df7938c77552ee06fe00b
ToppCell	PBMC-Severe-Myeloid-cDC-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	4.87e-06	197	56	5	f78f44dcd7855c96f148678c1f416075aef71b4e
ToppCell	COVID-19-COVID-19_Severe-Myeloid-cDC\|COVID-19_Severe / Disease, condition lineage and cell class	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	5.25e-06	200	56	5	e7b808d8ed65343a4345fafb03015fe4f7ce302f
ToppCell	mild-cDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FBLN2 HLA-DPB1 GRN SPECC1 TNFRSF21	5.25e-06	200	56	5	d6409ee5b9067be3dd2f852825e09151b5b22d7c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FBLN2 HLA-DPB1 GRN TNFRSF21	6.06e-05	169	56	4	a0681317867e31319210a23e56660a53f4529efe
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	DAB2IP CCDC169 KDM5D SPECC1	6.94e-05	175	56	4	c58a1f02d1e559d3638fe1500e960e82a8a7187b
ToppCell	droplet-Spleen-nan-24m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM220A MKI67 SPECC1 ATP2B4	7.57e-05	179	56	4	f3f9c7e575bc4d9d3bce649b90254182e8f6aaec
ToppCell	droplet-Spleen-nan-24m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM220A MKI67 SPECC1 ATP2B4	7.57e-05	179	56	4	01e0b49e7f03ac9c3e6c34708ead300d27236b8b
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENAM FBLN2 ABI3BP KDM5D	7.90e-05	181	56	4	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 ABI3BP ATP9A FGD6	8.60e-05	185	56	4	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 ABI3BP ATP9A FGD6	8.60e-05	185	56	4	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	FBLN2 HLA-DPB1 GRN SPECC1	8.78e-05	186	56	4	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	FBLN2 HLA-DPB1 GRN SPECC1	8.78e-05	186	56	4	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	3'_v3-blood-Myeloid_Dendritic-DC2\|blood / Manually curated celltypes from each tissue	FBLN2 HLA-DPB1 CTNNA3 TNFRSF21	8.96e-05	187	56	4	9f3db9f0e5de34aeabfe5984f675bc7a65435df7
ToppCell	COVID_non-vent-Myeloid-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	FBLN2 HLA-DPB1 SPECC1 TNFRSF21	8.96e-05	187	56	4	936aaca144b79a809617cbe3058bf434a4b3d46a
ToppCell	COVID_non-vent-Myeloid-Dendritic-cDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	FBLN2 HLA-DPB1 SPECC1 TNFRSF21	8.96e-05	187	56	4	55fe4e8b4f301876716c1af15c34d42164f2358e
ToppCell	ILEUM-non-inflamed-(8)_Activated_fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DBF4B APLP1 KIF13A PALB2	9.53e-05	190	56	4	39fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLIP3 FBLN2 ANK2 ABI3BP	9.73e-05	191	56	4	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ATXN2 RBM33 ZFC3H1 SRRM2	9.92e-05	192	56	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	Control-B_intermediate-10\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FBLN2 ANK2 HLA-DPB1 GRN	9.92e-05	192	56	4	224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	FBLN2 HLA-DPB1 GRN SPECC1	9.92e-05	192	56	4	8e606eae3e5b07a856d3c2a74186d486da96309c
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 INF2 APLP1 ATP9A	1.01e-04	193	56	4	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	ATXN2 RBM33 ZFC3H1 SRRM2	1.01e-04	193	56	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.03e-04	194	56	4	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 ANK2 APLP1 ATP9A	1.03e-04	194	56	4	ba529c051f248d29f4222f4bc9801ba233859093
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.03e-04	194	56	4	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.03e-04	194	56	4	6af2971d83f5ad6aed16d0ceb8bfc52f3947bc10
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.03e-04	194	56	4	5c60670ec24470225fabaa6071fdb4ef6e579840
ToppCell	10x5'-Liver-Myeloid_Dendritic\|Liver / Manually curated celltypes from each tissue	INF2 HLA-DPB1 GRN TNFRSF21	1.03e-04	194	56	4	e6391bc7073831847c469ef0b0c437118e1f151f
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 ANK2 APLP1 SRRM2	1.03e-04	194	56	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 APLP1 KDM5D SRRM2	1.05e-04	195	56	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 APLP1 KDM5D SRRM2	1.05e-04	195	56	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	e1f763fa9c11bf5f4d80e79f70f9485724ac23fe
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 ANK2 SBF1 APLP1	1.07e-04	196	56	4	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	Control-Myeloid-cDC\|Control / Disease group, lineage and cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	85d92bc226cc28384c30991cc4ebb02ec2e3ec99
ToppCell	healthy_donor-Myeloid-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	ea590b8ea3d13ff93cb5863a44936b0cfdf3b868
ToppCell	control-immature_Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ATRIP KDM5C GRN SPECC1	1.07e-04	196	56	4	e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	553c22c7d48f3b4f6f2b2f10d6e668c5ebb09e8c
ToppCell	COVID-19_Moderate-cDC\|World / disease group, cell group and cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	92a236adf386f05d020b1954bbdc5bd32346cbf0
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	0bac14c018487ca67e7f9255b5f186e7ae665774
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	d376168e15ec1cf618723259966c76be3698b9b0
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	33345338c825484960daa1ed82a19df38ccfc5c0
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	4a9095ba3f6709f88f32bf09184553f4bd211f43
ToppCell	healthy_donor-Myeloid-Dendritic-cDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	FBLN2 HLA-DPB1 GRN SPECC1	1.07e-04	196	56	4	aac79fc45cab4a16e2fa02652ece0999591261a5
ToppCell	PBMC-Mild-Myeloid-cDC-cDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	9162ede5572326c00ede0769fe7f4e0dd14d2340
ToppCell	PBMC-Mild-Myeloid-cDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	021c9c48375259b808e1f36a029c4fe6971c00eb
ToppCell	PBMC-Mild-Myeloid-cDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	18df0e447bcea2a405a357563f87bacc57466227
ToppCell	PBMC-Mild-Myeloid-cDC-cDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	0460b6907743a354792b5bc40bff01aac7c41684
ToppCell	COVID-19_Mild-Myeloid-cDC\|COVID-19_Mild / Disease group, lineage and cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	2901904b8a791fac2668fd737eff7e7144378db4
ToppCell	Monocytes-cDCs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	3388c104af4c6a05988e102627e0c5e34d9dcc45
ToppCell	Healthy/Control-cDC\|Healthy/Control / Disease group and Cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.10e-04	197	56	4	926423aae9fcf654f84b0f7621103a6a22d3aced
ToppCell	mild_COVID-19-cDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	FBLN2 GRN SPECC1 TNFRSF21	1.10e-04	197	56	4	44ebd3f967779bb7753fc6dcd9fde6d682f9ccd6
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D231\|Adult / Lineage, Cell type, age group and donor	CEP170 KSR1 HLA-DPB1 GRN	1.12e-04	198	56	4	79a415e19cedde13a88f5043d71557363f102322
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 ANK2 SBF1 APLP1	1.12e-04	198	56	4	a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 ANK2 SBF1 APLP1	1.12e-04	198	56	4	43a2ce64fa309bac89a44ea320e87ae2cc39f782
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.12e-04	198	56	4	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLIP3 FBLN2 ANK2 ABI3BP	1.12e-04	198	56	4	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 ANK2 APLP1 ATP9A	1.12e-04	198	56	4	27f0654fb0857e93f030e1a4b1c307b31576bbcd
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	ANK2 ABI3BP PKD1 ATP2B4	1.12e-04	198	56	4	9f9dcf23ffb333105263132d87b90095642294cf
ToppCell	COVID-19_Severe-cDC\|World / disease group, cell group and cell class	HLA-DPB1 GRN SPECC1 TNFRSF21	1.12e-04	198	56	4	c452334249f047265ae89dcabe7de446d968cae6
ToppCell	Control-Control-Others-RBC\|Control / Disease, condition lineage and cell class	ENAM HLA-DPB1 GRN TNFRSF21	1.14e-04	199	56	4	eb4c52d04f572433c0239bf479d0040a309939a1
ToppCell	Control-Control-Myeloid-tDC\|Control / Disease, condition lineage and cell class	FBLN2 HLA-DPB1 GRN TNFRSF21	1.14e-04	199	56	4	e758dc2145cb595a1b4f272523fc789b3d802eb1
ToppCell	control-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.14e-04	199	56	4	31825ba336603fe940dea6022e18ec25af110f4c
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CLIP3 FBLN2 ANK2 ABI3BP	1.14e-04	199	56	4	60a653100aff31f7f96796ff2ec634798bfb4b0d
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.14e-04	199	56	4	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Fibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	8d75ce89393df452defacf2ec9a5bd4b7708afbb
ToppCell	mild-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FBLN2 HLA-DPB1 SPECC1 TNFRSF21	1.16e-04	200	56	4	86f585bf9066b179bbcbc703bf43f15da4a07284
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 ANK2 SBF1 APLP1	1.16e-04	200	56	4	0e85c90719d9ec51a566e230c9dd2909d8df1f52
ToppCell	Bronchial-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	5ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCell	Control-Control-Myeloid-cDC\|Control / Disease, condition lineage and cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.16e-04	200	56	4	1375d199320feb85ba06e74b10df6521e790addf
ToppCell	Parenchymal-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	2e525c0d9684e7a2275edb04e1addb6fc6a872e5
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RBM33 ZFC3H1 SRRM2 DDX3X	1.16e-04	200	56	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	6e3d1ae0ef84d3075afa40129a41169996462672
ToppCell	COVID-19-COVID-19_Mild-Myeloid-cDC\|COVID-19_Mild / Disease, condition lineage and cell class	FBLN2 HLA-DPB1 GRN SPECC1	1.16e-04	200	56	4	b8f52e65813d331c49cdd5f354fdfec6fc8c339e
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	6316c288022719b9e6c4332c5cb9041e1188d0e8
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	6b48ddde83bc6c941d557844aa214d4d2c8e736d
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	HLA-DPB1 SRRM2 FMNL1 DDX3X	1.16e-04	200	56	4	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	severe-immature_Neutrophil\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	STXBP5 MKI67 GRN ATP9A	1.16e-04	200	56	4	a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCell	severe-cDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FBLN2 HLA-DPB1 SPECC1 TNFRSF21	1.16e-04	200	56	4	26e04ea276dbca5cde48335c401269c7123b54d2
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	7ba292c30d915e66ebc8026fa76492cedf64700e
ToppCell	Tracheal-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CLIP3 FBLN2 ANK2 ABI3BP	1.16e-04	200	56	4	920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KSR1 FAM220A SPECC1	1.62e-04	84	56	3	6c8018d65df335c81fe4099a34e0053c8dbcf88d
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC169 FBLN2 MKI67	4.40e-04	118	56	3	f0f40a0165156e3fc1584480b473b0e84e10d2cc
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC169 FBLN2 MKI67	4.51e-04	119	56	3	a6b359e7aafcc197f53eb5e19c3a905bc09497bb
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-6\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	CCDC169 WEE2 LCT	5.21e-04	125	56	3	dd59d6ca4d36f9453eb1b1f260fab36c5d641cb2
ToppCell	primary_visual_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	FBLN2 ATP2B4 FMNL1	7.40e-04	141	56	3	605d7b28e99c943f64b4095855a6f9f70e92cb09
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ABI3BP MYO7B PALB2	7.55e-04	142	56	3	58bfff3284ae21150e4619511bd58622c16c5dde
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	ABI3BP MYO7B PALB2	7.55e-04	142	56	3	5fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ABI3BP MYO7B PALB2	7.55e-04	142	56	3	16f9945e835c3506b12d904778560d065a50f059
Computational	Neighborhood of AF1Q	CLIP3 ANK2 ATP9A	8.20e-05	25	37	3	GNF2_AF1Q
Disease	KDEL motif-containing protein 2 measurement	POGLUT3 EXPH5	2.04e-05	4	55	2	EFO_0801740
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	2.04e-05	4	55	2	DOID:0060809 (implicated_via_orthology)
Disease	bronchopulmonary dysplasia	CEP170 STXBP5 CTNNA3	8.23e-05	45	55	3	MONDO_0019091
Disease	developmental disorder of mental health (implicated_via_orthology)	DAB2IP NCOR1 SIN3A	1.06e-04	49	55	3	DOID:0060037 (implicated_via_orthology)
Disease	Huntington's disease (is_marker_for)	NCOR1 KDM5C SIN3A	1.34e-04	53	55	3	DOID:12858 (is_marker_for)
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	POGLUT3 EXPH5	1.52e-04	10	55	2	EFO_1000650, HP_0000131
Disease	Ischemic stroke, tissue plasminogen activator measurement	ATXN2 STXBP5	3.53e-04	15	55	2	EFO_0004791, HP_0002140
Disease	intellectual disability (implicated_via_orthology)	ANK2 KDM5C KDM5D	3.76e-04	75	55	3	DOID:1059 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	4.03e-04	16	55	2	DOID:0050888 (implicated_via_orthology)
Disease	graft-versus-host disease (is_implicated_in)	HLA-DPB1 MKI67	4.56e-04	17	55	2	DOID:0081267 (is_implicated_in)
Disease	factor VIII measurement, Ischemic stroke	ATXN2 STXBP5	5.72e-04	19	55	2	EFO_0004630, HP_0002140
Disease	factor VIII measurement, von Willebrand factor measurement	DAB2IP STXBP5	1.16e-03	27	55	2	EFO_0004629, EFO_0004630
Disease	Amyotrophic Lateral Sclerosis With Dementia	ATXN2 TNFRSF21	1.34e-03	29	55	2	C0393554
Disease	longevity, healthspan, parental longevity	ATXN2 FGD6	1.34e-03	29	55	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	von Willebrand factor measurement, coronary artery disease	DAB2IP ATXN2 STXBP5	1.41e-03	118	55	3	EFO_0001645, EFO_0004629
Disease	Ischemic stroke, von Willebrand factor measurement	ATXN2 STXBP5	1.44e-03	30	55	2	EFO_0004629, HP_0002140
Disease	Amyotrophic Lateral Sclerosis, Guam Form	ATXN2 TNFRSF21	1.53e-03	31	55	2	C0543859

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKIPPLVHSKTPEGN	CEP170	1366	Q5SW79
VSIVRPRHGPKRKPV	C16orf86	96	Q6ZW13
KRGPVKKITRPNHLP	CCDC169	196	A6NNP5
PKGEPRVSRLPRHQK	FAM220A	146	Q7Z4H9
PTGTHPLAKKLPAQR	GRN	181	P28799
HTLAVVGKVTPTPRP	APLP1	276	P51693
RVQPRVNVSPSKKGP	HLA-DPB1	121	P04440
VHKTPRSPLSGIPVR	SPECC1	841	Q5M775
RRQVFGHNVIPPKKP	ATP2B4	76	P23634
PQDTKPGVKRTVTHR	RBM33	956	Q96EV2
LRKPQTPPTVTNHVG	INTS6L	631	Q5JSJ4
RTEKHPPVSPGRTEK	ANK2	1921	Q01484
KRPVTRITPHPGNEV	MBD3L1	36	Q8WWY6
TRPTPVQKHAIPIIK	DDX3X	201	O00571
LKPRAVHKQGPSPVS	DAB2IP	981	Q5VWQ8
GVSHLRPEPPKTRVS	FAM47C	446	Q5HY64
VVSGVPRLSPKTHRP	ATXN2	676	Q99700
KPHSIPLRQSVQPSK	KDM5D	191	Q9BY66
PTREVPRKPQVLPHS	FBLN2	401	P98095
PPTTPQLRRHTKLKP	KSR1	271	Q8IVT5
SRIVQHKTPRLNPPS	LCT	1211	P09848
KSGFIPPRHQQSPKR	EXPH5	351	Q8NEV8
PPAQKGPTLTTKVRR	ATP9A	436	O75110
RPATPKKPVGEVHSQ	MKI67	691	P46013
GRPRPSPLVKAHKSV	INF2	346	Q27J81
PSKVEGVHTPRQKRS	PACS1	496	Q6VY07
SAHTPGRPPRVTKDK	SBF1	1031	O95248
IVLPGKSHPKRPNSQ	PALB2	676	Q86YC2
KIIRIQSPAGPRHPV	CTNNA3	831	Q9UI47
KGSHPRPSRKPVDSV	DBF4B	126	Q8NFT6
VSGRKPHPFPSVSKI	EI24	156	O14681
GPPSSVPKSRHLTIK	FMNL1	191	O95466
LRRKPQGPNKHPVGT	ENAM	401	Q9NRM1
SHVSPRKNPSVVIKP	ATRIP	221	Q8WXE1
PSPTQERRQKPVVHP	CLIP3	31	Q96DZ5
GPSRTPLRAKNKVHP	PKD1	4286	P98161
EVPSTAPVSGKKHRP	nan	266	A6NNC1
VLHPPPSNTKQGERK	KIF13A	36	Q9H1H9
VSQPRRHSRPVPSGK	REXO1	206	Q8N1G1
PSPKPTKVHIGRLTR	RNPS1	156	Q15287
HPKVKSGTPPRQGSI	SRRM2	841	Q9UQ35
TPIKGPKRGHPRQNL	TNFRSF21	326	O75509
KPVSPPPVEQKHRSI	NCOR1	221	O75376
QIRRHPTGTTPPVKK	SIN3A	426	Q96ST3
VRSPAKPVQTITPHG	STXBP5	266	Q5T5C0
HIKTSTVPPSLRKQP	ATF6B	656	Q99941
EHRKVNGTPSPIPII	POGLUT3	246	Q7Z4H8
HKGGVPPQRTRKTCI	MRPS18B	81	Q9Y676
QSSVLGKGVKHRPPP	SUPT20H	451	Q8NEM7
PKKPQRHSLPATGVL	FGD6	496	Q6ZV73
LRPKSHPETGKKPVR	ZNF217	271	O75362
VISPTGKLPSRGPKH	WEE2	121	P0C1S8
VDSTHPTKKPGTRRP	ABI3BP	686	Q7Z7G0
PGTRLQTHRKTVVTP	TOPBP1	766	Q92547
GPRLPRTVISLPKHK	ZFC3H1	691	O60293
KPHSIPLRQSVQPSK	KDM5C	191	P41229
IQKVLRTGPRKQPPH	MYO7B	1771	Q6PIF6