Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein autophosphorylation	TNIK STK10 MYO3A TAOK3 EIF2S1 TAOK1 STK39 MVP WNK3 WNK2	2.36e-05	228	173	10	GO:0046777
GeneOntologyBiologicalProcess	negative regulation of sodium ion transport	STK39 AGRN WNK3 WNK2	3.11e-05	22	173	4	GO:0010766
GeneOntologyCellularComponent	spectrin	SPTA1 SPTB SPTBN5	4.51e-05	9	173	3	GO:0008091
MousePheno	abnormal erythrocyte osmotic lysis	SPTA1 SPTB NEK1 KCNN4 ABCG5	1.30e-05	30	145	5	MP:0003657
MousePheno	hemolysis	SPTA1 SPTB NEK1 KCNN4 ABCG5	2.45e-05	34	145	5	MP:0010163
MousePheno	increased erythrocyte osmotic fragility	SPTA1 SPTB KCNN4 ABCG5	3.04e-05	18	145	4	MP:0031085
Domain	Orange_dom	HES2 HEY1 HES7 HES4 HES6	4.84e-08	12	173	5	IPR003650
Domain	Hairy_orange	HES2 HEY1 HES7 HES4 HES6	4.84e-08	12	173	5	PF07527
Domain	ORANGE	HES2 HEY1 HES7 HES4 HES6	7.80e-08	13	173	5	PS51054
Domain	EGF_LAM_2	LAMA2 LAMA3 LAMC3 CELSR3 AGRN	7.60e-06	30	173	5	PS50027
Domain	EGF_LAM_1	LAMA2 LAMA3 LAMC3 CELSR3 AGRN	7.60e-06	30	173	5	PS01248
Domain	OSR1_C	STK39 WNK3 WNK2	1.53e-05	6	173	3	PF12202
Domain	Kinase_OSR1/WNK_CCT	STK39 WNK3 WNK2	1.53e-05	6	173	3	IPR024678
Domain	EGF_Lam	LAMA2 LAMA3 LAMC3 CELSR3 AGRN	1.67e-05	35	173	5	SM00180
Domain	Laminin_EGF	LAMA2 LAMA3 LAMC3 CELSR3 AGRN	1.67e-05	35	173	5	PF00053
Domain	Laminin_EGF	LAMA2 LAMA3 LAMC3 CELSR3 AGRN	2.52e-05	38	173	5	IPR002049
Domain	LAMININ_IVA	LAMA2 LAMA3 LAMC3	4.23e-05	8	173	3	PS51115
Domain	Laminin_B	LAMA2 LAMA3 LAMC3	4.23e-05	8	173	3	PF00052
Domain	LamB	LAMA2 LAMA3 LAMC3	4.23e-05	8	173	3	SM00281
Domain	Laminin_IV	LAMA2 LAMA3 LAMC3	4.23e-05	8	173	3	IPR000034
Domain	ORANGE	HES2 HEY1 HES4	6.30e-05	9	173	3	SM00511
Domain	P-loop_NTPase	KIF21B ABCC3 ATRX TDRD9 ABCA13 MFHAS1 MYH7B DHX37 KIF4A RAD54L2 GEM SRPRB KIFC2 EHD2 MYO3A MTHFD1 HLTF ABCG5 DDX28 MOV10	1.19e-04	848	173	20	IPR027417
Domain	Spectrin_repeat	SPTA1 SPTB PPL SPTBN5	1.41e-04	29	173	4	IPR002017
Domain	SPEC	SPTA1 SPTB PPL SPTBN5	2.09e-04	32	173	4	SM00150
Domain	Spectrin/alpha-actinin	SPTA1 SPTB PPL SPTBN5	2.09e-04	32	173	4	IPR018159
Domain	CH	SPTB SMTN SPTBN5 EHBP1L1 IQGAP3	3.39e-04	65	173	5	SM00033
Domain	Laminin_N	LAMA2 LAMA3 LAMC3	4.00e-04	16	173	3	IPR008211
Domain	LamNT	LAMA2 LAMA3 LAMC3	4.00e-04	16	173	3	SM00136
Domain	LAMININ_NTER	LAMA2 LAMA3 LAMC3	4.00e-04	16	173	3	PS51117
Domain	Laminin_N	LAMA2 LAMA3 LAMC3	4.00e-04	16	173	3	PF00055
Domain	LAM_G_DOMAIN	LAMA2 LAMA3 CELSR3 AGRN	4.10e-04	38	173	4	PS50025
Domain	CH	SPTB SMTN SPTBN5 EHBP1L1 IQGAP3	4.79e-04	70	173	5	PF00307
Domain	Helicase_C	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	4.83e-04	107	173	6	PF00271
Domain	HELICc	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	4.83e-04	107	173	6	SM00490
Domain	Helicase_C	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	5.08e-04	108	173	6	IPR001650
Domain	-	SPTB SMTN SPTBN5 EHBP1L1 IQGAP3	5.11e-04	71	173	5	1.10.418.10
Domain	HELICASE_CTER	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	5.33e-04	109	173	6	PS51194
Domain	HELICASE_ATP_BIND_1	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	5.33e-04	109	173	6	PS51192
Domain	DEXDc	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	5.33e-04	109	173	6	SM00487
Domain	Helicase_ATP-bd	ATRX TDRD9 DHX37 RAD54L2 HLTF DDX28	5.60e-04	110	173	6	IPR014001
Domain	CH	SPTB SMTN SPTBN5 EHBP1L1 IQGAP3	5.81e-04	73	173	5	PS50021
Domain	CH-domain	SPTB SMTN SPTBN5 EHBP1L1 IQGAP3	6.58e-04	75	173	5	IPR001715
Domain	LamG	LAMA2 LAMA3 CELSR3 AGRN	7.23e-04	44	173	4	SM00282
Domain	Laminin_domII	LAMA2 LAMA3	8.38e-04	5	173	2	IPR010307
Domain	Atypical_DUSP_famA	STYXL2 DUSP26	8.38e-04	5	173	2	IPR020405
Domain	Laminin_aI	LAMA2 LAMA3	8.38e-04	5	173	2	IPR009254
Domain	Laminin_I	LAMA2 LAMA3	8.38e-04	5	173	2	PF06008
Domain	Laminin_II	LAMA2 LAMA3	8.38e-04	5	173	2	PF06009
Domain	Spectrin	SPTA1 SPTB SPTBN5	1.21e-03	23	173	3	PF00435
Domain	RPEL	MYOCD PHACTR1	1.74e-03	7	173	2	PS51073
Domain	RPEL	MYOCD PHACTR1	1.74e-03	7	173	2	SM00707
Domain	RPEL	MYOCD PHACTR1	1.74e-03	7	173	2	PF02755
Domain	RPEL_repeat	MYOCD PHACTR1	1.74e-03	7	173	2	IPR004018
Domain	Laminin_G	LAMA2 LAMA3 CELSR3 AGRN	2.04e-03	58	173	4	IPR001791
Domain	DUF1220	NBPF4 NBPF6	2.94e-03	9	173	2	SM01148
Domain	SNF2_N	ATRX RAD54L2 HLTF	3.18e-03	32	173	3	IPR000330
Domain	SNF2_N	ATRX RAD54L2 HLTF	3.18e-03	32	173	3	PF00176
Domain	-	HES2 HEY1 HES7 HES4 HES6	3.46e-03	109	173	5	4.10.280.10
Domain	HLH	HES2 HEY1 HES7 HES4 HES6	3.74e-03	111	173	5	PF00010
Domain	-	ABCC3 ATRX TDRD9 ABCA13 MFHAS1 DHX37 RAD54L2 GEM SRPRB EHD2 MTHFD1 HLTF ABCG5 DDX28 MOV10	4.04e-03	746	173	15	3.40.50.300
Domain	DUF1220	NBPF4 NBPF6	4.44e-03	11	173	2	PF06758
Domain	NBPF_dom	NBPF4 NBPF6	4.44e-03	11	173	2	IPR010630
Domain	Laminin_G_1	LAMA2 AGRN	4.44e-03	11	173	2	PF00054
Domain	NBPF	NBPF4 NBPF6	4.44e-03	11	173	2	PS51316
Domain	HLH	HES2 HEY1 HES7 HES4 HES6	4.52e-03	116	173	5	SM00353
Domain	BHLH	HES2 HEY1 HES7 HES4 HES6	4.68e-03	117	173	5	PS50888
Domain	bHLH_dom	HES2 HEY1 HES7 HES4 HES6	4.85e-03	118	173	5	IPR011598
Domain	Laminin_G_2	LAMA2 LAMA3 CELSR3	6.00e-03	40	173	3	PF02210
Domain	Ser/Thr_kinase_AS	TNIK STK10 NEK1 MYO3A TAOK3 TAOK1 STK39 WNK3 WNK2	6.16e-03	357	173	9	IPR008271
Domain	Atypical_DUSP	STYXL2 DUSP26	6.22e-03	13	173	2	IPR020417
Domain	S_TKc	TNIK STK10 NEK1 MYO3A TAOK3 TAOK1 STK39 WNK3 WNK2	6.38e-03	359	173	9	SM00220
Domain	Kinesin_motor_CS	KIF21B KIF4A KIFC2	6.43e-03	41	173	3	IPR019821
Domain	PROTEIN_KINASE_ST	TNIK STK10 NEK1 MYO3A TAOK3 TAOK1 STK39 WNK3 WNK2	6.73e-03	362	173	9	PS00108
Domain	Kinesin-like_fam	KIF21B KIF4A KIFC2	7.35e-03	43	173	3	IPR027640
Domain	-	KIF21B KIF4A KIFC2	7.83e-03	44	173	3	3.40.850.10
Domain	Kinesin	KIF21B KIF4A KIFC2	7.83e-03	44	173	3	PF00225
Domain	KISc	KIF21B KIF4A KIFC2	7.83e-03	44	173	3	SM00129
Domain	KINESIN_MOTOR_1	KIF21B KIF4A KIFC2	7.83e-03	44	173	3	PS00411
Domain	Kinesin_motor_dom	KIF21B KIF4A KIFC2	7.83e-03	44	173	3	IPR001752
Domain	KINESIN_MOTOR_2	KIF21B KIF4A KIFC2	7.83e-03	44	173	3	PS50067
Domain	Pkinase	TNIK STK10 NEK1 MYO3A TAOK3 TAOK1 STK39 WNK3 WNK2	9.24e-03	381	173	9	PF00069
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 ARHGEF19 NUP85 LPAR5 NRF1 MFHAS1 LAMC3 HES2 KIFC2 CCDC88C STK10 EHBP1L1 WIZ KANSL1 CELSR3 CLCN7 KCNH2 MAD1L1 PDZD8 HES6 GPC2 SNAPC4 MRPL46 HECTD1 AGRN IQGAP3 WNK2 EVI5L	3.08e-12	1105	178	28	35748872
Pubmed	Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.	HES2 HEY1 HES7 HES4 HES6	1.50e-09	11	178	5	17611704
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	TNIK KIF21B POP4 CAND2 NUP85 LPAR5 TCHP MYH7B MKRN2 TENT5C LAMC3 OGDH GTF3C5 CAPN11 EVI5 JARID2 DUSP26 EHBP1L1 LRIG1 CEP250 TIMELESS STK39 SNAPC4	1.09e-07	1242	178	23	30973865
Pubmed	Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter.	WNT9B HES2 DUSP26 HEY1 HES7 HES6 MYOCD	3.12e-07	86	178	7	35103284
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	EPRS1 POP4 SPTB GPKOW OGDH PPL EHD2 EHBP1L1 CGN KDM2A STK39 MVP	3.92e-07	360	178	12	33111431
Pubmed	Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain.	LAMA2 AGRN SNTA1	5.25e-07	4	178	3	32072250
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EPRS1 AARS1 ARHGEF28 NUP85 ATRX DHX37 RAD54L2 ECT2 POLR3A SACM1L TAOK3 HLTF TIMELESS AGRN IQGAP3	1.46e-06	650	178	15	38777146
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KIF21B AARS1 DHX37 SRPRB TOE1 TAOK3 MTHFD1 FGB UNG TAOK1 ADGRF3 CDH7 GOLGA1	1.93e-06	497	178	13	36774506
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ATRX DHX37 KIF4A GPKOW GTF3C5 WIZ HLTF UNG KDM2A TIMELESS SNAPC4 NOP2 ZHX1 SENP7	3.38e-06	608	178	14	36089195
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	NPHP1 AARS1 CAND2 ATRX NRF1 TCHP STYXL2 ECT2 GTF3C5 HAUS8 NEK1 CEP44 PSMG1 CGN CCDC154 BLOC1S3 KATNIP IQGAP3 MOV10 CCDC93 CCDC40	4.52e-06	1321	178	21	27173435
Pubmed	A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse.	HES2 HES7 HES6	4.54e-06	7	178	3	19306043
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	KIF21B SPTA1 SPTB EPX ANKRD36B SPTBN5 CELSR3 MTHFD1	5.88e-06	187	178	8	26460568
Pubmed	Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease.	SPTA1 SPTB HEPH	1.08e-05	9	178	3	658175
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EPRS1 ATRX PPL SMTN STK10 MYO3A KANSL1 MAD1L1 MSL3 UNG TAOK1 TIMELESS SNAPC4 NOP2 ZHX1	1.18e-05	774	178	15	15302935
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SACM1L CEP44 CFAP74 WNK2 SENP7 PHACTR1	1.48e-05	102	178	6	11214970
Pubmed	Phenotypic annotation of the mouse X chromosome.	ATRX AKAP17A KIF4A ATP11C WNK3	1.57e-05	61	178	5	20548051
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CAND2 NUP85 GOSR1 OGDH GEM SRPRB POLR3A SACM1L SMTN EHD2 EVI5 AFAP1 EIF2S1 CEP44 PSMG1 HLTF COG5 NOP2 MOV10 CCDC93 EVI5L	1.66e-05	1440	178	21	30833792
Pubmed	Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.	HES2 HEY1 HES7 HES6	1.87e-05	31	178	4	19666558
Pubmed	Regional differences in the expression of laminin isoforms during mouse neural tube development.	LAMA2 LAMA3 LAMC3	2.11e-05	11	178	3	21524702
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RALGAPA1 GOSR1 OGDH GTF3C5 SACM1L NEK1 TAOK3 KIDINS220 HLTF ATP11C TAOK1 DDX28	2.15e-05	533	178	12	25544563
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EPRS1 AARS1 DHX37 KIF4A ECT2 SRPRB GTF3C5 TOE1 POLR3A SMTN KANSL1 MTHFD1 EIF2S1 HLTF KDM2A NOP2 MVP AGRN MOV10 CCDC93	2.21e-05	1353	178	20	29467282
Pubmed	Macromolecular organization of basement membranes.	LAMA2 LAMA3	2.60e-05	2	178	2	8939648
Pubmed	A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).	SPTA1 SPTB	2.60e-05	2	178	2	1391962
Pubmed	An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).	SPTA1 SPTB	2.60e-05	2	178	2	2070088
Pubmed	Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.	SPTA1 SPTB	2.60e-05	2	178	2	15492010
Pubmed	Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.	SPTA1 SPTB	2.60e-05	2	178	2	8102379
Pubmed	Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.	SPTA1 SPTB	2.60e-05	2	178	2	9414314
Pubmed	Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	9373273
Pubmed	Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.	SPTA1 SPTB	2.60e-05	2	178	2	9005995
Pubmed	HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins.	HLTF UNG	2.60e-05	2	178	2	27335459
Pubmed	Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	7104494
Pubmed	A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	6215583
Pubmed	Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia.	SPTA1 SPTB	2.60e-05	2	178	2	30198572
Pubmed	Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	8844207
Pubmed	Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.	SPTA1 SPTB	2.60e-05	2	178	2	2056132
Pubmed	Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma.	LRIG3 LRIG1	2.60e-05	2	178	2	23165628
Pubmed	Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	2346784
Pubmed	Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	3580577
Pubmed	Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.	SPTA1 SPTB	2.60e-05	2	178	2	7883966
Pubmed	Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin.	LAMA2 AGRN	2.60e-05	2	178	2	16103356
Pubmed	A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.	CLCN7 CCDC154	2.60e-05	2	178	2	20121924
Pubmed	Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.	SPTA1 SPTB	2.60e-05	2	178	2	9163587
Pubmed	Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.	KIF4A MVP	2.60e-05	2	178	2	29204984
Pubmed	Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.	SPTA1 SPTB	2.60e-05	2	178	2	8018926
Pubmed	Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.	ATRX NEK1	2.60e-05	2	178	2	27264870
Pubmed	Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.	SPTA1 SPTB	2.60e-05	2	178	2	8226774
Pubmed	Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site.	SPTA1 SPTB	2.60e-05	2	178	2	1634521
Pubmed	The Evi5 family in cellular physiology and pathology.	EVI5 EVI5L	2.60e-05	2	178	2	23669355
Pubmed	Erythrocyte spectrin is comprised of many homologous triple helical segments.	SPTA1 SPTB	2.60e-05	2	178	2	6472478
Pubmed	Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.	SPTA1 SPTB	2.60e-05	2	178	2	22164239
Pubmed	Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.	SPTA1 SPTB	2.60e-05	2	178	2	20197550
Pubmed	A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.	SPTA1 SPTB	2.60e-05	2	178	2	17977835
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EPRS1 NUP85 DHX37 MKRN2 LAMA3 GPKOW ECT2 SRPRB GTF3C5 TOE1 PPL AFAP1 MTHFD1 EIF2S1 CGN NOP2 MVP IQGAP3 MOV10	2.65e-05	1257	178	19	36526897
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	CAND2 DHX37 ECT2 SRPRB GTF3C5 TOE1 NEK1 WIZ MTHFD1 MRPL46 HECTD1 NOP2	2.77e-05	547	178	12	37267103
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	LAMA2 LAMA3 AGRN	2.80e-05	12	178	3	16750824
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	NUP85 KIF4A GPKOW ECT2 GTF3C5 PPL SMTN HAUS8 KANSL1 MAD1L1 MSL3 FGB TIMELESS COG5 NOP2 IQGAP3 DDX28 MOV10	2.94e-05	1155	178	18	20360068
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	EPRS1 AARS1 CAND2 NUP85 TMEM115 SRPRB SACM1L KIDINS220 BRI3BP LRIG1 EIF2S1 TIMELESS COG5 HECTD1 IQGAP3 WNK3	3.01e-05	942	178	16	31073040
Pubmed	[IMAGE: molecular integration of the analysis of the human genome and its expression].	C21orf58 BEX3 CDH7 WNK3	3.07e-05	35	178	4	7757816
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	NUP85 DHX37 MKRN2 ECT2 TOE1 SACM1L KIDINS220 HECTD1 IQGAP3 MOV10	4.44e-05	400	178	10	35013556
Pubmed	Basement membrane composition in the early mouse embryo day 7.	LAMA2 LAMA3 LAMC3	5.73e-05	15	178	3	15895400
Pubmed	Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.	LAMA2 LAMA3 LAMC3	7.03e-05	16	178	3	17601529
Pubmed	Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.	STK39 WNK3	7.79e-05	3	178	2	26861815
Pubmed	Spectrin's E2/E3 ubiquitin conjugating/ligating activity is diminished in sickle cells.	SPTA1 SPTB	7.79e-05	3	178	2	15929114
Pubmed	Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain.	LAMA2 LAMC3	7.79e-05	3	178	2	10225960
Pubmed	A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin.	HEY1 GDF11	7.79e-05	3	178	2	34510201
Pubmed	Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo.	SPTA1 SPTB	7.79e-05	3	178	2	1385865
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK3 TAOK1	7.79e-05	3	178	2	17396146
Pubmed	Inherited hemolytic disease in mice: a review and update.	SPTA1 SPTB	7.79e-05	3	178	2	6763106
Pubmed	The extracellular matrix protein agrin promotes heart regeneration in mice.	AGRN SNTA1	7.79e-05	3	178	2	28581497
Pubmed	Redistribution of LRIG proteins in psoriasis.	LRIG3 LRIG1	7.79e-05	3	178	2	18037903
Pubmed	The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.	SPTA1 SPTB	7.79e-05	3	178	2	20585040
Pubmed	Renal and brain isoforms of WNK3 have opposite effects on NCCT expression.	STK39 WNK3	7.79e-05	3	178	2	19470686
Pubmed	Tumor formation via loss of a molecular motor protein.	ABCC3 KIF4A	7.79e-05	3	178	2	16890532
Pubmed	LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.	LRIG3 LRIG1	7.79e-05	3	178	2	27628597
Pubmed	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.	LRIG3 LRIG1	7.79e-05	3	178	2	33469151
Pubmed	Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia.	SPTA1 SPTB	7.79e-05	3	178	2	29884876
Pubmed	The autophagic membrane tether ATG2A transfers lipids between membranes.	WIPI1 WDR45	7.79e-05	3	178	2	31271352
Pubmed	Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II.	STK39 WNK3	7.79e-05	3	178	2	24019400
Pubmed	PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.	WIPI1 WDR45	7.79e-05	3	178	2	15020712
Pubmed	WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.	WNK3 WNK2	7.79e-05	3	178	2	18768590
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALGAPA1 ATRX NRF1 TCHP SPTB LAMA3 CTIF PPM1K OGDH STK10 KIDINS220 BRI3BP MAD1L1 KATNIP KDM2A PRORP HECTD1 PCDH1 WNK2 EVI5L	8.32e-05	1489	178	20	28611215
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RALGAPA1 ARHGEF28 NUP85 GOSR1 SH3GLB2 LAMC3 NBPF6 SMTN HAUS8 WDR45 MAD1L1 MSL3 UNG NOP2 SENP7	9.00e-05	925	178	15	28986522
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTA1 SPTB SPTBN5	1.02e-04	18	178	3	12119179
Pubmed	Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.	LAMA2 LAMA3 LAMC3	1.02e-04	18	178	3	11311202
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ABCA13 MYH7B PPL CCDC88C KIDINS220 CGN IQGAP3	1.04e-04	208	178	7	33230847
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	TCHP HAUS8 NEK1 TBC1D31 CEP44 CEP250	1.11e-04	146	178	6	21399614
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPRS1 AARS1 ATRX AKAP17A SPTB SH3GLB2 ACTR3B RAD54L2 BEX3 WIZ CELSR3 HEY1 PSMG1 PDZD8 TAOK1 HECTD1 MVP SNTA1	1.14e-04	1285	178	18	35914814
Pubmed	Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.	LAMA2 LAMA3 LAMC3	1.41e-04	20	178	3	22911573
Pubmed	Identification and characterization of human HES2, HES3, and HES5 genes in silico.	HES2 HES4	1.55e-04	4	178	2	15254753
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK3 WNK2	1.55e-04	4	178	2	34384519
Pubmed	Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort.	TNFRSF6B PSMG1	1.55e-04	4	178	2	21079743
Pubmed	Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes.	SPTA1 SPTB	1.55e-04	4	178	2	6234993
Pubmed	Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.	KANSL1 MSL3	1.55e-04	4	178	2	21217699
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTA1 SPTB	1.55e-04	4	178	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTA1 SPTB	1.55e-04	4	178	2	3862089
Pubmed	The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes.	SPTA1 SPTB	1.55e-04	4	178	2	379653
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK3 WNK2	1.55e-04	4	178	2	11571656
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTA1 SPTB	1.55e-04	4	178	2	21412925
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK3 WNK2	1.55e-04	4	178	2	11498583
Pubmed	Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia.	SPTA1 SPTB	1.55e-04	4	178	2	10772878
Interaction	TOP3B interactions	EPRS1 ABCC3 ARHGEF19 NUP85 LPAR5 NRF1 MFHAS1 SPTB MKRN2 LAMC3 CTIF HES2 KIFC2 CCDC88C STK10 EHBP1L1 WIZ KANSL1 CELSR3 CLCN7 KCNH2 MAD1L1 PDZD8 HES6 GPC2 SNAPC4 MRPL46 HECTD1 NOP2 AGRN IQGAP3 DDX28 WNK2 MOV10 EVI5L	4.47e-08	1470	176	35	int:TOP3B
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTB SPTBN5	8.17e-06	7	113	3	1113
GeneFamily	Laminin subunits	LAMA2 LAMA3 LAMC3	5.02e-05	12	113	3	626
GeneFamily	Basic helix-loop-helix proteins	HES2 HEY1 HES7 HES4 HES6	6.34e-04	110	113	5	420
Coexpression	GSE21546_WT_VS_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN	NUP85 NRF1 TMEM115 LAMC3 ACTR3B TBC1D31 BRI3BP MTHFD1 UNG STK39	9.46e-07	196	177	10	M7551
Coexpression	ALFANO_MYC_TARGETS	GOSR1 SMTN AFAP1 CELSR3 CLCN7 KCNH2 PSMG1 KCNN4 MVP AGRN	5.59e-06	239	177	10	M2477
Coexpression	GSE11864_CSF1_VS_CSF1_IFNG_IN_MAC_DN	AARS1 STYXL2 SRPRB AFAP1 CCDC181 MRPL46 COG5 NOP2 MOV10	7.89e-06	196	177	9	M3135
Coexpression	HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL	NUP85 NRF1 C21orf58 LAMA2 KIF4A SNUPN ECT2 HEPH EHD2 VSTM4 HAUS8 MYO3A TBC1D31 BRI3BP LRIG1 HEY1 HES4 TIMELESS CDH7 IQGAP3 MOV10	9.62e-06	1054	177	21	M45798
Coexpression	DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP	NUP85 C21orf58 TENT5C KIF4A HAUS8 BRI3BP LRIG1 MTHFD1 UNG TIMELESS IQGAP3	1.33e-05	323	177	11	M2156
Coexpression	HE_LIM_SUN_FETAL_LUNG_C2_CYCLING_DC_CELL	AARS1 POP4 MED30 NUP85 BEND5 C21orf58 MKRN2 KIF4A SNUPN ECT2 SRPRB GTF3C5 TOE1 POLR3A THAP7 ANKRD36B HAUS8 BRI3BP MTHFD1 PSMG1 HLTF UNG TIMELESS MRPL46	3.34e-05	1423	177	24	M45722
Coexpression	WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP	ABCC3 ECT2 HEPH BRI3BP PDZD8 STK39 GALNT4	4.80e-05	140	177	7	M2435
Coexpression	GSE1460_CD4_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN	FBXL15 PKD2L1 CCDC88C STK10 LRIG1 KCNH2 MVP DDX28	6.53e-05	199	177	8	M3476
Coexpression	GSE19888_CTRL_VS_A3R_INHIBITOR_TREATED_MAST_CELL_UP	AARS1 C21orf58 SNUPN SMTN ANKRD36B HAUS8 MTHFD1 PRORP	6.77e-05	200	177	8	M7311
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ATRX CTIF EVI5 JARID2 STK10 NEK1 TAOK3 AFAP1 KIDINS220 TBC1D31 LRIG1 MAD1L1 HLTF PHLPP1 STK39 COG5 CCDC93	7.41e-05	856	177	17	M4500
Coexpression	HE_LIM_SUN_FETAL_LUNG_C4_CYCLING_NK_CELL	POP4 NUP85 TCHP C21orf58 SH3GLB2 KIF4A ECT2 TOE1 THAP7 HAUS8 BRI3BP MTHFD1 PSMG1 HLTF TIMELESS	7.89e-05	694	177	15	M45767
CoexpressionAtlas	DevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#5_top-relative-expression-ranked_500	POP4 CAND2 TCHP DHX37 TIMELESS IQGAP3 ABCG5 CCDC40	1.70e-05	134	177	8	gudmap_developingKidney_e11.5_metaneph mesench_500_k5
ToppCell	Epithelial-Epithelial-A_(AT1)\|Epithelial / shred on cell class and cell subclass (v4)	SLC17A2 LAMA3 CAVIN3 EHD2 WDR45 MTHFD1 LOX AGRN PHACTR1	1.00e-07	196	178	9	41b21a18125cc95bc8adde3369e4abd029cf137d
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC17A2 ARHGEF28 LAMA3 WDR45 MTHFD1 CGN AGRN PHACTR1	5.66e-07	176	178	8	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 ABCA13 WNT10B LAMA3 MTHFD1 CGN AGRN PHACTR1	7.29e-07	182	178	8	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 ABCA13 WNT10B LAMA3 MTHFD1 CGN AGRN PHACTR1	7.29e-07	182	178	8	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ARHGEF19 ANKRD36B LRIG1 ZNF425 CGN PHLPP1 WNK2 EVI5L	8.25e-07	185	178	8	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 ARHGEF28 LAMA3 WDR45 MTHFD1 CGN AGRN PHACTR1	1.27e-06	196	178	8	9790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 ARHGEF28 LAMA3 WDR45 MTHFD1 CGN AGRN PHACTR1	1.27e-06	196	178	8	b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF28 CAVIN3 PPL WDR45 MTHFD1 CGN AGRN PHACTR1	1.32e-06	197	178	8	b0fb5774525ba05f60c635d42f14bb8d79bff17c
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF28 CAVIN3 PPL WDR45 MTHFD1 CGN AGRN PHACTR1	1.32e-06	197	178	8	bbb7c106d5b96b8e95aeb3e5c293e104fceea234
ToppCell	10x3'2.3-week_17-19-Hematopoietic-erythroid-early_erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	EPRS1 C21orf58 SPTA1 SPTB KCNH2 PSMG1 HLTF KCNN4	1.37e-06	198	178	8	8d900a17667a41bdfa683a34275fe4c059f6a8ef
ToppCell	Dividing_Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ARHGEF28 ATRX C21orf58 KIF4A PKD2L1 ECT2 IQGAP3	4.82e-06	166	178	7	c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 SYCE1L EHD2 LOX CGN SNTA1 WNK2	5.42e-06	169	178	7	aec97583b23112060437b619cb429dc32f29285f
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMC3 CAVIN3 GEM EHD2 MYO3A HES4 AGRN	7.61e-06	178	178	7	e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BICDL2 ARHGEF28 WNT10B LAMA3 MTHFD1 CGN CCDC154	7.89e-06	179	178	7	88dbec952507d84b85b08165eec80df99ed1e736
ToppCell	facs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BICDL2 ARHGEF28 WNT10B LAMA3 MTHFD1 CGN CCDC154	7.89e-06	179	178	7	daf8189a22786171e2b629261cf720736aa4ebdb
ToppCell	Epithelial-lung_goblet_cell\|World / Lineage, Cell type, age group and donor	BICDL2 ARHGEF28 TENT5C LRIG1 HEY1 HES4 WNK2	9.12e-06	183	178	7	940cbe298e9c53b5622af09264586ed823d3141f
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	EPX SLC1A6 EHD2 BEX3 KCNH2 LOX CDH7	1.01e-05	186	178	7	943c604a7cd873faf510096d094100512ba2d6bc
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	EPX SLC1A6 EHD2 BEX3 KCNH2 LOX CDH7	1.01e-05	186	178	7	e69a986b8618effd61875fda528a2e44aab11868
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 WNT10B LAMA3 MTHFD1 CGN AGRN PHACTR1	1.25e-05	192	178	7	790282d4232311df3dac4ad97c80fc53443beccc
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 WNT10B LAMA3 MTHFD1 CGN AGRN PHACTR1	1.25e-05	192	178	7	b2d9bffccd6264b4f12d88a0780646ee0b41969f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 ARHGEF28 ABCA13 MFHAS1 LAMA3 PPL PHACTR1	1.33e-05	194	178	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMC3 CAVIN3 SMTN EHD2 HES4 MYOCD AGRN	1.33e-05	194	178	7	a7731378f44ca1a229311686caf5740c742d21ba
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	C21orf58 KIF4A ECT2 BRI3BP MTHFD1 HES4 IQGAP3	1.33e-05	194	178	7	4c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PKD2L1 CELSR3 KCNH2 HES6 ZHX1 WNK3 WNK2	1.33e-05	194	178	7	2dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMC3 CAVIN3 SMTN EHD2 HES4 MYOCD AGRN	1.42e-05	196	178	7	9a420a4eb46cb554bec641726fea5398ff60f630
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STYXL2 CAVIN3 GEM HEPH SMTN DUSP26 MYOCD	1.42e-05	196	178	7	5159d8625d80c20eb28157b2603c8bde9d377a35
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STYXL2 CAVIN3 GEM HEPH SMTN DUSP26 MYOCD	1.42e-05	196	178	7	6b5b7dbcb2cce8a736e44145a01290905876a5e9
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	MED30 NUP85 KIF4A ECT2 BLOC1S3 TIMELESS AGRN	1.47e-05	197	178	7	1bb8f9535a9ab6c7a444bcbe346fcc0a13b09bdf
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMC3 CAVIN3 SMTN EHD2 HES4 MYOCD AGRN	1.47e-05	197	178	7	983502a99e6d59bb36225b0246a9990604de1a01
ToppCell	erythropoietic-Basophilic_Erythroblast\|World / Lineage and Cell class	SPTA1 MTHFD1 KCNH2 PSMG1 HLTF HES6 UNG	1.52e-05	198	178	7	b3db4db02c0e659163cefb3d83f53e4940cc04bf
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPTA1 SPTB BEX3 KCNH2 PSMG1 HLTF WNK3	1.52e-05	198	178	7	8be58e41ae7870d268e7ce5ab937769e2ecb60d9
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma\|TCGA-Bladder / Sample_Type by Project: Shred V9	NUP85 KIF4A BLOC1S3 UNG TIMELESS AGRN IQGAP3	1.57e-05	199	178	7	8ee3dbc0a92de5f3865e5484970ae2aab7d1a956
ToppCell	TCGA-Bladder-Primary_Tumor\|TCGA-Bladder / Sample_Type by Project: Shred V9	NUP85 KIF4A BLOC1S3 UNG TIMELESS AGRN IQGAP3	1.57e-05	199	178	7	c403e28def2e14f5931cd73b4fb9a4078c0439f8
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BICDL2 ARHGEF28 ABCA13 PPL LRIG1 CGN HECTD1	1.62e-05	200	178	7	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Biopsy_Control_(H.)-Epithelial-Differentiating_Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	NPHP1 ABCA13 C21orf58 CFAP74 HES6 CCDC181 WNK2	1.62e-05	200	178	7	a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCell	distal-3-mesenchymal-Airway_Smooth_Muscle\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CAVIN3 GEM SMTN LSMEM2 DUSP26 HES4 MYOCD	1.62e-05	200	178	7	4072cfb3047954f507289587b4bfaf1526936992
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	C21orf58 KIF4A ECT2 MYO3A BRI3BP TIMELESS IQGAP3	1.62e-05	200	178	7	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	droplet-Fat-Mat-18m-Hematologic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 SPTB TENT5C KIF4A DCST1	2.91e-05	89	178	5	56039e126e6f3e8fcaf3c47237c980e514512536
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B TCHP GEM KIFC2 HES6 DDX28	3.15e-05	150	178	6	973252f4de9a1194aea9f3cb0e1f113643f16c91
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LAMA3 KIF4A PPL LSMEM2 KCNN4	3.59e-05	93	178	5	38a075f06001a2fd1ec77fc301a08a87618a2440
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LAMA3 KIF4A PPL LSMEM2 KCNN4	3.59e-05	93	178	5	a0117b12889d9c48294a7ccea4284d00c087889f
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LAMA3 KIF4A PPL LSMEM2 KCNN4	3.59e-05	93	178	5	b3e057132633b25bd4f8ff2c0aa203ade0f3ba4c
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPTA1 SPTB KCNH2 CCDC154 IQGAP3 PHACTR1	4.67e-05	161	178	6	8ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MFHAS1 GEM BEX3 HES6 NOP2 CCDC40	4.84e-05	162	178	6	64353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AARS1 HES2 SRPRB AFAP1 LRIG1 HLTF	5.18e-05	164	178	6	d8ecb3de6e34f5f574449e3d2f26fa0b2b7e84e8
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LAMA3 KIF4A PPL LSMEM2 KCNN4	5.60e-05	102	178	5	2c3622fc3cd62d9b7e185d0204cf7f03e7dde73c
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B CTIF ECT2 KIFC2 KCNN4 VPS37D	5.73e-05	167	178	6	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap-Excitatory_Neuron.Gad1Gad2.Sphkap-Tmem255a_(Basomedial_amygdaloid_nucleus_(BMA))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	WNT9B DCST1 TRIM40 ABCG5	5.96e-05	53	178	4	db4c0ec659fb1f3196aef6f989f27b25f710c551
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap-Excitatory_Neuron.Gad1Gad2.Sphkap-Tmem255a_(Basomedial_amygdaloid_nucleus_(BMA))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	WNT9B DCST1 TRIM40 ABCG5	5.96e-05	53	178	4	b2b5f47ab9012f08821f2a5f0be24847b5196094
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA3 KIF4A ECT2 MYO3A TIMELESS IQGAP3	6.12e-05	169	178	6	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGEF19 WIPI1 BEND5 SPTBN5 HAUS8 HES4	6.32e-05	170	178	6	fed8e982d2ce234c59d4016432ed8941df36df27
ToppCell	COVID-19-lung-RBC\|lung / Disease (COVID-19 only), tissue and cell type	LPAR5 C21orf58 SPTA1 SPTB TENT5C KCNH2	6.53e-05	171	178	6	0e8d63c8fbccdda4f1ef00de00667a50464b104b
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC166 CAND2 SPTB GDF11 ZHX1 PHF21B	6.96e-05	173	178	6	12f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	BICDL2 LAMA3 PPL CELSR3 CGN AGRN	7.19e-05	174	178	6	edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)\|367C / Donor, Lineage, Cell class and subclass (all cells)	BICDL2 LAMA3 PPL CELSR3 CGN AGRN	7.19e-05	174	178	6	65539f69100db0b7d90b1b39ee15ab8281f86461
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	SPTA1 KCNH2 CCDC154 KCNN4 IQGAP3 PHACTR1	7.66e-05	176	178	6	052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAVIN3 SMTN EHD2 DUSP26 KCNH2 MYOCD	7.90e-05	177	178	6	88403b055eb9fdf96e4695fb6e0d78179e30a1e3
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	ARHGEF19 MFHAS1 CEP44 MSL3 STK39 SENP7	7.90e-05	177	178	6	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAVIN3 SMTN EHD2 DUSP26 KCNH2 MYOCD	7.90e-05	177	178	6	8903aeaab61abd81a148ea623038c5114b8a183b
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	ABCC3 SPTA1 CAPN11 KCNH2 TRIM40 IQGAP3	8.40e-05	179	178	6	4e0cf069bc47328eda753a4edc7e89b8915d52bb
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	NRF1 BEND5 WNT10B VSTM4 MYO3A HEY1	8.66e-05	180	178	6	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT1-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BICDL2 IL17C DCST1 SRPRB PPL	8.73e-05	112	178	5	456278fb92dd41820fde8cf27c68fec45e15f972
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTA1 TENT5C BRI3BP KCNH2 KCNN4 PHLPP1	8.93e-05	181	178	6	fe2f8b4bd8b09be8ba933529a16e1dca08740dab
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SLC1A6 BEX3 PSMG1 KCNN4 PDZD8 CCDC181	8.93e-05	181	178	6	ee207ea171e2ffc22a7f850be57bb118a87e0f81
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells-RBC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTA1 TENT5C BRI3BP KCNH2 KCNN4 PHLPP1	8.93e-05	181	178	6	a16079b1c832456b974d9d06dd1a3eda63ac1bce
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMA2 LAMC3 CAVIN3 SMTN EHD2 HES4	9.21e-05	182	178	6	fc4a5bf784705efe7965ce43ac23c2a8e602e90a
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH7B SPTB LAMA2 PPM1K MYOCD WNK2	1.01e-04	185	178	6	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	C21orf58 LAMA3 KIF4A ECT2 MYO3A IQGAP3	1.01e-04	185	178	6	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	WIPI1 TMEM115 MAD1L1 HES6 KATNIP CCDC40	1.01e-04	185	178	6	46f4f6f20b1e152922f6f2ba1244c56e48a49b79
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMC3 GEM VSTM4 MYO3A HES4 AGRN	1.04e-04	186	178	6	6568358812f0ca4e0161a1a1b29682fbced35c79
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C21orf58 SPTB EPX KCNH2 MYOCD WNK2	1.04e-04	186	178	6	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C21orf58 SPTB EPX KCNH2 MYOCD WNK2	1.04e-04	186	178	6	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	C21orf58 KCNH2 HES4 HES6 GPC2 AGRN	1.04e-04	186	178	6	10565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTB LAMA3 LAMC3 VSTM4 MYO3A HES4	1.07e-04	187	178	6	b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MFHAS1 LAMA3 PPL STK39 HECTD1 PHF21B	1.07e-04	187	178	6	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	C21orf58 LAMA3 KIF4A ECT2 MYO3A IQGAP3	1.07e-04	187	178	6	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA2 LAMC3 GEM SMTN EHD2 VSTM4	1.07e-04	187	178	6	8ee3bf885897efd634c3a0567637142a9f55e693
ToppCell	P07-Hematopoietic-Erythroid\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SPTA1 SPTB TENT5C BNIPL KCNN4	1.07e-04	117	178	5	1820396bd590020a83fac3416d559e32f41eab61
ToppCell	LPS-IL1RA-Endothelial-Mes-Like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STYXL2 CAVIN3 TUSC1 KCNH2 MYOCD	1.07e-04	117	178	5	5a23770806b4612bed4ae6fd716abdec7f7f56c6
ToppCell	P07-Hematopoietic-Erythroid-enucleate_erythrocyte\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SPTA1 SPTB TENT5C BNIPL KCNN4	1.07e-04	117	178	5	43c7257788fe3d53d663365d1754aee6ad88bbc5
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	TNIK MYH7B PPM1K MYOCD WNK2 PHACTR1	1.10e-04	188	178	6	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SMTN CCDC88C DUSP26 LRIG1 KCNH2 MYOCD	1.10e-04	188	178	6	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	IPF-Stromal-SMC\|IPF / Disease state, Lineage and Cell class	CAVIN3 SMTN EHD2 DUSP26 HES4 MYOCD	1.10e-04	188	178	6	e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SMTN CCDC88C LRIG1 KCNH2 HES6 MYOCD	1.13e-04	189	178	6	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	TNIK MYH7B LAMA2 PPM1K WNK2 PHACTR1	1.17e-04	190	178	6	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SMTN CCDC88C DUSP26 LRIG1 KCNH2 MYOCD	1.17e-04	190	178	6	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	C21orf58 KIF4A ECT2 MAD1L1 TIMELESS IQGAP3	1.17e-04	190	178	6	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	GOSR1 SMTN HAUS8 AFAP1 CLCN7 COG5	1.20e-04	191	178	6	d7920f4a602b50d0ef064eb47001e71939695ed2
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	C21orf58 LAMA3 KIF4A ECT2 MYO3A IQGAP3	1.20e-04	191	178	6	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 ARHGEF28 LAMA3 MTHFD1 CGN AGRN	1.20e-04	191	178	6	ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 ARHGEF28 LAMA3 MTHFD1 CGN AGRN	1.20e-04	191	178	6	c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	C21orf58 KIF4A ECT2 SMTN TBC1D31 IQGAP3	1.20e-04	191	178	6	0ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA3 LAMC3 EHD2 DUSP26 HEY1 LOX	1.20e-04	191	178	6	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARHGEF28 LAMA3 KIF4A ECT2 MYO3A IQGAP3	1.23e-04	192	178	6	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	TNIK MYH7B PPM1K MYOCD WNK2 PHACTR1	1.23e-04	192	178	6	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	SPTA1 EHD2 BEX3 KCNH2 KCNN4 CCDC181	1.23e-04	192	178	6	cbc304c704e8524eee24a1619d0fbb2cf96c4976
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	ABCA13 C21orf58 PPL RSPH3 CFAP74 CCDC181	1.23e-04	192	178	6	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	RALGAPA1 EPRS1 ATRX GOSR1 TAOK1 HECTD1	1.27e-04	193	178	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	C21orf58 KIF4A ECT2 HAUS8 TIMELESS IQGAP3	1.31e-04	194	178	6	f9070035553bc68106a9e0bdf4b507715a138aba
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMC3 GEM SMTN EHD2 HES4 AGRN	1.31e-04	194	178	6	7a7406c3b021aeafde423d20290c681c3e8ea0a6
Drug	Methylergometrine maleate [113-42-8]; Up 200; 8.8uM; MCF7; HT_HG-U133A	MFHAS1 SPTA1 GOSR1 LAMA2 FBXL15 AFAP1 KCNH2 LOX KDM2A TIMELESS CCDC93	3.90e-07	194	178	11	5303_UP
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; MCF7; HT_HG-U133A	SLC17A2 TENT5C CCDC88C EHBP1L1 AFAP1 CLCN7 KCNH2 MSL3 SNAPC4 SNTA1	3.62e-06	197	178	10	4832_DN
Drug	Melatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A	RALGAPA1 ABCC3 NRF1 TNFRSF6B LAMA3 RAD54L2 SPTBN5 KCNH2 MVP CCDC93	3.78e-06	198	178	10	5393_DN
Disease	pseudohypoaldosteronism (implicated_via_orthology)	STK39 WNK3 WNK2	3.71e-06	6	170	3	DOID:4479 (implicated_via_orthology)
Disease	obsolete_red blood cell distribution width	SLC17A2 WIPI1 LPAR5 NRF1 SPTA1 SPTB MKRN2 PKD2L1 ECT2 CAPN11 VSTM4 STK10 TAOK3 EHBP1L1 KANSL1 LRIG1 KCNN4 ATP11C TAOK1 STK39 COG5 WNK3	1.07e-05	1347	170	22	EFO_0005192
Disease	Muscle hypotonia	RALGAPA1 KANSL1 MSL3	1.20e-04	17	170	3	C0026827
Disease	serum alanine aminotransferase measurement	ARHGEF19 MFHAS1 MYH7B FBXL15 PKD2L1 KIFC2 JARID2 AFAP1 PSMG1 BLOC1S3 ABCG5 WNK2 VPS37D EVI5L SENP7	1.62e-04	869	170	15	EFO_0004735
Disease	Hereditary elliptocytosis	SPTA1 SPTB	1.96e-04	4	170	2	cv:C0013902
Disease	hereditary spherocytosis (is_implicated_in)	SPTA1 SPTB	3.26e-04	5	170	2	DOID:12971 (is_implicated_in)
Disease	Hereditary spherocytosis	SPTA1 SPTB	3.26e-04	5	170	2	cv:C0037889
Disease	Anemia, hereditary spherocytic hemolytic	SPTA1 SPTB	3.26e-04	5	170	2	C0221409
Disease	supramarginal gyrus volume measurement	MFHAS1 NEK1 PRORP	3.48e-04	24	170	3	EFO_0010332
Disease	glucose measurement	TNIK WIPI1 MED30 CAND2 TENT5C EPX OGDH MYO3A TAOK1	3.79e-04	380	170	9	EFO_0004468
Disease	Elliptocytosis, Hereditary	SPTA1 SPTB	4.88e-04	6	170	2	C0013902
Disease	long QT syndrome (is_implicated_in)	KCNH2 SNTA1	6.80e-04	7	170	2	DOID:2843 (is_implicated_in)
Disease	central nervous system cancer (implicated_via_orthology)	HES2 HES4	6.80e-04	7	170	2	DOID:3620 (implicated_via_orthology)
Disease	microcephaly (implicated_via_orthology)	AARS1 DHX37 MAD1L1	8.24e-04	32	170	3	DOID:10907 (implicated_via_orthology)
Disease	Hereditary spherocytosis	SPTA1 SPTB	9.03e-04	8	170	2	C0037889
Disease	gamma-glutamylisoleucine measurement	LAMA2 TUSC1	1.16e-03	9	170	2	EFO_0021139
Disease	octadecanedioate measurement	LAMA2 LAMC3	1.44e-03	10	170	2	EFO_0021056
Disease	Autism Spectrum Disorders	LAMC3 JARID2 HEY1 IQGAP3	1.50e-03	85	170	4	C1510586
Disease	late-onset Alzheimers disease	TUSC1 LRIG3 LRIG1 CFAP74 AGRN CDH7 SENP7	1.58e-03	292	170	7	EFO_1001870
Disease	Sepsis, mortality	GTF3C5 MAD1L1	1.75e-03	11	170	2	EFO_0004352, HP_0100806
Disease	Congenital long QT syndrome	KCNH2 SNTA1	1.75e-03	11	170	2	cv:C1141890
Disease	HbA1c measurement	TNIK MED30 SPTA1 SPTB MKRN2 PKD2L1 HAUS8 LRIG1 MAD1L1 STK39 ABCG5	1.93e-03	675	170	11	EFO_0004541
Disease	subiculum volume	TNIK AFAP1 WNK2	1.96e-03	43	170	3	EFO_0009399
Disease	Dental enamel hypoplasia	MYH7B DHX37	2.10e-03	12	170	2	EFO_1001304
Disease	Long QT syndrome	KCNH2 SNTA1	2.10e-03	12	170	2	cv:C0023976
Disease	ADHD symptom measurement	NRL ACTR3B	2.10e-03	12	170	2	EFO_0007860
Disease	Paroxysmal atrial fibrillation	CAND2 LRIG1 KCNH2 MYOCD COG5	2.15e-03	156	170	5	C0235480
Disease	familial atrial fibrillation	CAND2 LRIG1 KCNH2 MYOCD COG5	2.15e-03	156	170	5	C3468561
Disease	Persistent atrial fibrillation	CAND2 LRIG1 KCNH2 MYOCD COG5	2.15e-03	156	170	5	C2585653
Disease	brain connectivity measurement	TNIK MFHAS1 CCDC88C VSTM4 AFAP1 KANSL1 WNK2 MOV10	2.32e-03	400	170	8	EFO_0005210
Disease	Atrial Fibrillation	CAND2 LRIG1 KCNH2 MYOCD COG5	2.39e-03	160	170	5	C0004238
Disease	mean platelet volume	NRF1 SPTA1 TENT5C PKD2L1 NBPF6 EPX AFAP1 KCNN4 BLOC1S3 TAOK1 ADGRF3 TRIM40 MVP VPS37D	2.42e-03	1020	170	14	EFO_0004584
Disease	Testicular Germ Cell Tumor	STK10 MAD1L1	2.87e-03	14	170	2	C1336708
Disease	Hypermetropia	LAMA2 CCDC88C BLOC1S3 AGRN	3.02e-03	103	170	4	HP_0000540
Disease	inflammatory biomarker measurement, YKL40 measurement	ARHGEF28 RSPH3 PHLPP1	3.19e-03	51	170	3	EFO_0004869, EFO_0004872
Disease	Williams-Beuren syndrome (implicated_via_orthology)	LOX NOP2	3.30e-03	15	170	2	DOID:1928 (implicated_via_orthology)
Disease	hemoglobin A1 measurement	SPTA1 SPTB TENT5C PKD2L1 VSTM4 TAOK3 LRIG1 MAD1L1 COG5	3.32e-03	520	170	9	EFO_0007629
Disease	Romano-Ward Syndrome	KCNH2 SNTA1	3.76e-03	16	170	2	C0035828
Disease	central nervous system disease (implicated_via_orthology)	TAOK3 TAOK1	3.76e-03	16	170	2	DOID:331 (implicated_via_orthology)
Disease	omega-3 polyunsaturated fatty acid measurement	OGDH KANSL1 PSMG1 VPS37D	4.90e-03	118	170	4	EFO_0010119
Disease	migraine disorder, type 2 diabetes mellitus	CTIF AFAP1 MAD1L1	5.05e-03	60	170	3	MONDO_0005148, MONDO_0005277
Disease	apolipoprotein B measurement	ARHGEF19 MKRN2 FBXL15 PKD2L1 EVI5 FGB BLOC1S3 TAOK1 ABCG5 CCDC93	5.26e-03	663	170	10	EFO_0004615
Disease	Schizophrenia	TNIK ABCA13 IL17C LAMA2 SLC1A6 JARID2 MTHFD1 KCNH2 EIF2S1 MAD1L1 BLOC1S3 WNK3	5.28e-03	883	170	12	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDRIQRNKAAALLRL	UNG	71	P13051
LRDLNRRLQDVLLLR	BEND5	231	Q7L4P6
IKRLRTENRLLKQRI	EVI5L	381	Q96CN4
ARIQLDRRALKNLLI	ADGRF3	541	Q8IZF5
QTNFRLLKRRLREIL	APOBEC3D	371	Q96AK3
VRLLNIRLNRVLESL	BRI3BP	231	Q8WY22
QRLRRTGLQKVQSLR	CAVIN3	176	Q969G5
TLLQSSKDRLRRRLK	CTIF	341	O43310
EIRRKLRELQLRNCL	BEX3	76	Q00994
LRNRLAQLRKERKDL	AFAP1	581	Q8N556
QRDLKRVVDARLRLS	ACTR3B	336	Q9P1U1
LRKLNDLVKRARLVR	EHD2	291	Q9NZN4
RALLRQIQVSRRRSL	AGRN	1221	O00468
LKRSLRNLEQVLRLL	CEP44	6	Q9C0F1
AQVAAILARRLRRTL	ABCA13	4206	Q86UQ4
LRSKLEKQRESRQRL	ANKRD36B	1021	Q8N2N9
SQALKNIRSRRRVVL	RAD54L2	476	Q9Y4B4
QNLLRLLRKAVERSS	CAPN11	256	Q9UMQ6
ATRSLLRELLQVRAR	CCDC154	96	A6NI56
LQLLQRLRDLNISKR	EFCC1	521	Q9HA90
KREKRTLVLRDRNLS	MKRN2	101	Q9H000
RASLVLILKTIRRRL	NBPF4	591	Q96M43
QVRRRVLLSSRLLQD	PPM1K	16	Q8N3J5
SNRKRRRLKETLAQL	ECT2	376	Q9H8V3
KRRARINESLQELRL	HES6	36	Q96HZ4
EKASELRIQLRRARQ	GEM	166	P55040
RQLVCLARALLRKSR	ABCC3	1431	O15438
NFIKLRNSNLLARRR	ARHGEF28	976	Q8N1W1
SLSARLRNLRENKRV	ARHGEF19	776	Q8IW93
IRGRSRKLAELLLRN	KIDINS220	376	Q9ULH0
NSLIQRINLRKRRDS	GOSR1	216	O95249
EALARRLQKRVLLLT	MAD1L1	391	Q9Y6D9
LSSQLLRRNEQIRKL	GOLGA1	56	Q92805
LRRNEQIRKLEARLS	GOLGA1	61	Q92805
RLLIDDQLLRNSKRL	LAMA3	2861	Q16787
ALRRRKRLLEQEKSL	KCNN4	11	O15554
SQRRRKTVRLLLANL	LPAR5	226	Q9H1C0
LSRSLLTLRLSKNRI	LRIG1	186	Q96JA1
ISSKREILRRLNENL	NEK1	706	Q96PY6
RDAALRARKLRSNLR	MFHAS1	16	Q9Y4C4
RARKLRSNLRQLTLT	MFHAS1	21	Q9Y4C4
DKLRRLILQGNRIRS	LRIG3	386	Q6UXM1
RRLRLQITRTLVAAR	GPC2	211	Q8N158
LEKRRRARINQSLSQ	HES2	21	Q9Y543
ILLSELSRRRIRSIN	EIF2S1	46	P05198
LSRRRIRSINKLIRI	EIF2S1	51	P05198
ELRRSLELSVNLQRK	KATNIP	181	O60303
TARLLRLVRVARKLD	KCNH2	526	Q12809
LDRRLRKNLRALVVV	BNIPL	281	Q7Z465
LADTKARLRRVRQEL	CCDC88C	256	Q9P219
RSNLGLVQRRLRLKD	CLCN7	696	P51798
RVLRSILENLRSKIQ	FGB	196	P02675
RDQRLAKVLTLLQAR	MYH7B	826	A7E2Y1
RLSLARNLARAIIRE	NUP85	636	Q9BW27
VRRLLRLDRNTGLIT	PCDH1	326	Q08174
QIDKLRAELRRLQRR	PPL	1381	O60437
RRIDRTLKNLRLEGQ	PDZD8	896	Q8NEN9
RQRKALSRISLSRII	EPX	661	P11678
RLRTENRLLKQRIET	EVI5	431	O60447
VLRRKTQEVSALRRL	KIF21B	811	O75037
FLLQEALRRKRERLQ	KIF21B	951	O75037
EALRLKQRRRTLKNR	NRL	156	P54845
VRRSRLVKDALRQLS	HERC6	676	Q8IVU3
RLQRKLARKAVARLR	MSL3	81	Q8N5Y2
PSIRKRQQTRLLRKL	NRF1	101	Q16656
RQQTRLLRKLRATLD	NRF1	106	Q16656
LVQKIELAARRRRSL	DDX28	511	Q9NUL7
RGLEQRRRKLSRQLS	EHBP1L1	1501	Q8N3D4
QADIESRARRLQKRL	KANSL1	291	Q7Z3B3
LLSRDRARSRALVQL	GPKOW	436	Q92917
IRLRFQRIRTLNADL	LAMA2	241	P24043
LNSVRLLQSLLVLRR	IL17C	146	Q9P0M4
KRRLLLSQRKRELAD	HAUS8	196	Q9BT25
LDLRQLTRAGLRRLQ	GPR45	236	Q9Y5Y3
KQRRVLRNLRRLEAL	IQGAP3	1436	Q86VI3
NLRQLSVLFRKLRLV	MED30	81	Q96HR3
LIRSKFRSVLQLRLQ	MYOCD	11	Q8IZQ8
TIIRQNQALRLRARK	MVP	166	Q14764
RLELRQQIGTKLTRR	PHACTR1	451	Q9C0D0
EVRLQLARKREVRLL	PSMG1	36	O95456
RRINRVTDRNITLSL	OGDH	356	Q02218
RTRQLRLEAKRSKQL	CCDC181	476	Q5TID7
LRRIIRILNLSKRLQ	COG5	176	Q9UP83
KIRLLQARRNREIAI	CCDC93	466	Q567U6
RIELRERRNLSSKRN	ATRX	1131	P46100
NLQILTRRLRFRLER	HECTD1	991	Q9ULT8
RFKRRQLLRLQATER	KDM2A	756	Q9Y2K7
ALKRRRDLLQRLREQ	C21orf58	136	P58505
TKLRRAAILRRERQQ	DCST1	606	Q5T197
SNLDRVRLIRTNKRE	GALNT4	191	Q8N4A0
RLRQELLLLLRRTQL	CCDC166	226	P0CW27
LFRSKQSLVLERQRL	CCDC40	1086	Q4G0X9
KALTLVRSVLTRRRQ	CEP250	386	Q9BV73
ELRVLENTKRSRRNL	GDF11	286	O95390
LLRRVTRNLVRNKLA	ABCG5	371	Q9H222
TRNLVRNKLAVITRL	ABCG5	376	Q9H222
LQESLQQRALRTRLR	SLC1A6	26	P48664
RSLLQLRLAESQARL	BLOC1S3	106	Q6QNY0
LSALRRLQRRVSELE	BICDL2	266	A1A5D9
LSRELLRAIRQKVAL	BICDL2	431	A1A5D9
TRSLDLTRIVRRLQN	GUCA1A	171	P43080
RRARINESLAQLKTL	HES4	46	Q9HCC6
ILLIRDNRTAAARTR	LOX	91	P28300
LLKLRLASLSQLRRL	LSMEM2	141	Q8N112
RRSSLLRQLLKLDSE	FAM47A	256	Q5JRC9
QAKLSERRRKRLQEL	KIF4A	591	O95239
IIEKRRRDRINNSLS	HEY1	56	Q9Y5J3
RRLQSLIKNITLRRT	HLTF	631	Q14527
LRNLNVIRDTKTRRD	CDH7	671	Q9ULB5
QLDLLLRRQLSRERL	CELSR3	3071	Q9NYQ7
RLLLLERTRDQNLRN	HES7	36	Q9BYE0
LRKNQRALRLATLAA	CAND2	661	O75155
QREVQRLRSAKELLR	CROCCP3	51	Q8IVE0
GLLSRIVTLRAKRNL	DHX37	386	Q8IY37
SLLARRSLQAQLQRL	SACM1L	401	Q9NTJ5
VRRFSDIQIRRLKRL	MTHFD1	486	P11586
VERNRLLRIRKSLNT	CFAP74	216	Q9C0B2
RRLREAQTINRSLLA	KIFC2	651	Q96AC6
VKLRSLNRRSRNVLS	NPHP1	551	O15259
LQLREGLRNSKRRLE	JARID2	431	Q92833
RTSLNRKLDRNLVLL	MRPL46	146	Q9H2W6
TLISRKTKRRLRNNL	SENP7	296	Q9BQF6
LIRSRRSSQRAVLLV	SRPRB	56	Q9Y5M8
RSRKLRKDIAELQRL	TRIM40	121	Q6P9F5
RRRLLSVNIRVRADL	EPRS1	1331	P07814
LLLQRRRVTVRKADA	SNTA1	81	Q13424
RKLLRVLQRTLSALA	TBC1D31	471	Q96DN5
LLLVVRKLLRTNSRF	TDRD9	266	Q8NDG6
RASLVLILKTIRRRL	NBPF6	591	Q5VWK0
IRLDLNRKEVLTLRL	MOV10	141	Q9HCE1
LLRLQRVSRAFRSLV	FBXL15	41	Q9H469
QRKLRRNRRSILDDS	HEPH	1136	Q9BQS7
KLSLERIRLLRLEVN	POLR3A	1131	O14802
LSARQRRELRLFDIK	POP4	76	O95707
SKERRLLQNRRLDLD	SH3GLB2	156	Q9NR46
LRELEQRVSLRRALL	TAOK1	831	Q7L7X3
RELQKLEQRVSLRRA	TAOK3	826	Q9H2K8
LKDTRLNRRSALARV	WDR45	266	Q9Y484
IDTLREILKRRTQSR	WIZ	1081	O95785
SERRRRLLELQKSKR	SNUPN	41	O95149
RSKEQLLSERRLVRA	SYCE1L	156	A8MT33
TLKTRRRDLAQALIN	NOP2	316	P46087
SQLAKRNLRLLVLGR	PRORP	431	O15091
RQLLALDRRLRQGLE	DUSP26	196	Q9BV47
QRLLQLQRLETLARR	SPTBN5	416	Q9NRC6
RRQTLNLISLLALRV	TENT5C	326	Q5VWP2
CKRREQRLRLRLTKL	THAP7	261	Q9BT49
QRLRLRLTKLQQERA	THAP7	266	Q9BT49
RKLLLAQRNLQSIRL	AKAP17A	361	Q02040
RRRILGLEQQLKETR	CGN	736	Q9P2M7
LLIVLKNVRRRSARR	ATP11C	1086	Q8NB49
RELSIQRRSALNVRL	TIMELESS	326	Q9UNS1
SLELQRQREARKRAL	RSPH3	216	Q86UC2
RLQLANKERSEALRR	TNIK	356	Q9UKE5
KLLRELRNLDSRQCR	RALGAPA1	1791	Q6GYQ0
QSSLDRLRALLRLIQ	PHF21B	476	Q96EK2
LSRGRRILDRKIQSL	AARS1	386	P49588
RRELIELRNKVNRLL	TFG	106	Q92734
KKRQRRLELLERSRQ	STYXL2	621	Q5VZP5
LRRQELRELRLLQKE	STK10	561	O94804
ERRRQLALKALNERL	TMEM115	281	Q12893
LLSRNLLRLITVRKL	SLC17A2	336	O00624
EELNRLRAQTKLTRR	ZHX1	596	Q9UKY1
VLSRTSKFRRLRQLL	nan	311	A8MX80
KRRSLEARREKLRQL	TCHP	76	Q9BT92
LLQSRRQRLETTLAL	SPTB	516	P11277
AATRRRLLKESLLLQ	SPTA1	571	P02549
RRTQAEKLQELLRRR	VPS37D	161	Q86XT2
TLLRLRLRKERVSDV	PKD2L1	591	Q9P0L9
REKLQEILNLLRVRR	TRIML1	136	Q8N9V2
VLSRISKFRRLRQLL	nan	311	Q8N9G6
VLSRTSKFRRLRQLL	nan	311	A8MUA0
ANSLLLRRGRLKRNL	PHLPP1	116	O60346
LLRKSVVSDRLQRLL	SNAPC4	191	Q5SXM2
TSSLLLRIRKRTRRQ	GTF3C5	81	Q9Y5Q8
SRSAKRRRLRLLEEQ	VSTM4	91	Q8IW00
SNILSIRLNRQRLLV	WIPI1	101	Q5MNZ9
RLRAKLLQLQALSRG	WNT10B	156	O00744
LQRRVLLLCKTRRLI	WNK2	71	Q9Y3S1
DLLKLSRRQKQLCRR	WNT9B	56	O14905
AVNLVLRLRNSRKEL	STK39	451	Q9UEW8
LRLRNSRKELNDIRF	STK39	456	Q9UEW8
SELRRTQRLLCQKKR	ZNF425	231	Q6IV72
KLIRAALRELRQRKR	SMTN	606	P53814
QSVRTLFLELIRARR	TOE1	171	Q96GM8
LSRTSKFRRLRQLLR	nan	311	A6NL46
LRLENRRLKRENRSL	TUSC1	96	Q2TAM9
RRLKRENRSLFRQAL	TUSC1	101	Q2TAM9
AALQLKLRRRLTELL	TNFRSF6B	251	O95407
IRQNKSERLSIRDLL	WNK3	386	Q9BYP7
QRLLANLTSLRLRVS	LAMC3	626	Q9Y6N6
RLLRKTSQRRRLVQQ	MYO3A	1601	Q8NEV4